KR20140129164A - 히스톤 데아세틸라아제 억제제 및 파조파닙의 조합물 및 이의 용도 - Google Patents

히스톤 데아세틸라아제 억제제 및 파조파닙의 조합물 및 이의 용도 Download PDF

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Publication number
KR20140129164A
KR20140129164A KR1020147025547A KR20147025547A KR20140129164A KR 20140129164 A KR20140129164 A KR 20140129164A KR 1020147025547 A KR1020147025547 A KR 1020147025547A KR 20147025547 A KR20147025547 A KR 20147025547A KR 20140129164 A KR20140129164 A KR 20140129164A
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KR
South Korea
Prior art keywords
salt
abecinostat
cancer
pazopanib
hcl
Prior art date
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Withdrawn
Application number
KR1020147025547A
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English (en)
Korean (ko)
Inventor
스리람 발라수브라마니안
타라크 디 모디
Original Assignee
파마시클릭스, 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 파마시클릭스, 인코포레이티드 filed Critical 파마시클릭스, 인코포레이티드
Publication of KR20140129164A publication Critical patent/KR20140129164A/ko
Withdrawn legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020147025547A 2012-02-17 2013-02-15 히스톤 데아세틸라아제 억제제 및 파조파닙의 조합물 및 이의 용도 Withdrawn KR20140129164A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261600491P 2012-02-17 2012-02-17
US61/600,491 2012-02-17
US201261602544P 2012-02-23 2012-02-23
US61/602,544 2012-02-23
PCT/US2013/026462 WO2013123413A2 (en) 2012-02-17 2013-02-15 Combinations of histone deacetylase inhibitor and pazopanib and uses thereof

Publications (1)

Publication Number Publication Date
KR20140129164A true KR20140129164A (ko) 2014-11-06

Family

ID=48984895

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020147025547A Withdrawn KR20140129164A (ko) 2012-02-17 2013-02-15 히스톤 데아세틸라아제 억제제 및 파조파닙의 조합물 및 이의 용도

Country Status (12)

Country Link
US (1) US20150335609A1 (enExample)
EP (1) EP2814493A4 (enExample)
JP (1) JP2015507020A (enExample)
KR (1) KR20140129164A (enExample)
CN (1) CN104244952A (enExample)
AU (1) AU2013221298A1 (enExample)
CA (1) CA2864736A1 (enExample)
HK (1) HK1204998A1 (enExample)
MX (1) MX2014009892A (enExample)
RU (1) RU2014137190A (enExample)
SG (1) SG11201404888SA (enExample)
WO (1) WO2013123413A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20220018727A (ko) 2020-08-07 2022-02-15 계명대학교 산학협력단 파조파닙 또는 이의 약학적으로 허용가능한 염을 유효성분으로 함유하는 비만 예방 또는 치료용 조성물

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3079699A4 (en) * 2013-12-11 2017-07-19 Glaxosmithkline LLC Treating cancer with a combination of a pd-1 antagonist and a vegfr inhibitor
AU2016296905B2 (en) * 2015-07-23 2018-07-05 Centre National De La Recherche Scientifique Use of a combination of Dbait molecule and parp inhibitors to treat cancer
WO2017053823A1 (en) * 2015-09-25 2017-03-30 Pharmacyclics Llc Treatment using hdac inhibitors and immunotherapy
US11229657B2 (en) * 2017-04-21 2022-01-25 Lunella Biotech, Inc. Targeting hypoxic cancer stem cells (CSCs) with doxycycline: implications for improving anti-angiogenic therapy
JP7227777B2 (ja) * 2019-02-04 2023-02-22 キヤノン株式会社 撮像装置
US20240075031A1 (en) * 2020-12-07 2024-03-07 Hht Foundation International, Inc. Method of treating hereditary hemorrhagic telangiectasia using pazopanib

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004230889B2 (en) * 2003-04-07 2008-03-13 Pharmacyclics Llc Hydroxamates as therapeutic agents
WO2005105094A2 (en) * 2004-04-16 2005-11-10 Smithkline Beecham Corporation Cancer treatment method
DE602006020611D1 (de) * 2005-11-29 2011-04-21 Glaxosmithkline Llc Krebsbehandlungsverfahren
CN102245184A (zh) * 2008-12-15 2011-11-16 伊莱利利公司 用于治疗癌症的恩扎妥林
US8603521B2 (en) * 2009-04-17 2013-12-10 Pharmacyclics, Inc. Formulations of histone deacetylase inhibitor and uses thereof
UY33367A (es) * 2010-05-05 2011-10-31 Glaxo Wellcome Mfg Pte Ltd Composiciones farmacéuticas y métodos para su elaboración
SG191926A1 (en) * 2011-01-26 2013-08-30 Glaxosmithkline Intellectual Property Ltd Combinations

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20220018727A (ko) 2020-08-07 2022-02-15 계명대학교 산학협력단 파조파닙 또는 이의 약학적으로 허용가능한 염을 유효성분으로 함유하는 비만 예방 또는 치료용 조성물

Also Published As

Publication number Publication date
AU2013221298A1 (en) 2014-08-28
MX2014009892A (es) 2015-02-12
CA2864736A1 (en) 2013-08-22
SG11201404888SA (en) 2014-09-26
EP2814493A4 (en) 2015-07-22
CN104244952A (zh) 2014-12-24
EP2814493A2 (en) 2014-12-24
RU2014137190A (ru) 2016-04-10
US20150335609A1 (en) 2015-11-26
HK1204998A1 (en) 2015-12-11
JP2015507020A (ja) 2015-03-05
WO2013123413A2 (en) 2013-08-22

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Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20140912

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
N231 Notification of change of applicant
PN2301 Change of applicant

Patent event date: 20151211

Comment text: Notification of Change of Applicant

Patent event code: PN23011R01D

PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid