KR20140125217A - Cosmetic Composition for Improving Nail Surface Condition Comprising Extract from Cedrela sinensis as Active Ingredient - Google Patents
Cosmetic Composition for Improving Nail Surface Condition Comprising Extract from Cedrela sinensis as Active Ingredient Download PDFInfo
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- KR20140125217A KR20140125217A KR20130043112A KR20130043112A KR20140125217A KR 20140125217 A KR20140125217 A KR 20140125217A KR 20130043112 A KR20130043112 A KR 20130043112A KR 20130043112 A KR20130043112 A KR 20130043112A KR 20140125217 A KR20140125217 A KR 20140125217A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q3/00—Manicure or pedicure preparations
- A61Q3/02—Nail coatings
Abstract
Description
The present invention relates to a cosmetic composition for improving the nail condition comprising an extract of Chamaecyparis obtusa as an active ingredient.
Nails are nails or claws, and in medical terms they are called onyx. Manicure is defined as the coloring of fingernails or the management of fingernails, which have been commonly used to refer to products. Manicure is a Latin word derived from manus (hand) and cura (care). It is a combination of nails, cuticle theorem, hand massage, nail coloring, etc. This means nail care (Park So-jung and Seowon Sook 2009). From ancient times, nails have attracted more attention in terms of beauty than health. The nail has been constantly damaged over a lifetime, and the damage of natural nails is getting worse especially due to the expansion of artificial nail market which emphasized personality recently (Lee Eun-young et al., 2009). Nails have the function of holding and scraping objects and decorations, and play an important role in the hands (Tos et al. 2012). The nail matrix, the nail bed, the cuticle, the nail plate, the proximal nail fold, the lateral nail fold, the nail end corner, and the distal edge of the plate play an essential role in nail growth and development (Schoon 2005). The necrotic layer is composed of a dorsal layer, an intermediate layer, and a ventral layer, which protects the ancestor (De Berker et al., 2007; The nail is formed by a nail matrix and is slightly elastic and translucent and convex (Murdan 2002). It grows about 0.1 mm a day, takes about 4-6 months to fully regenerate, and takes about 8-12 months . Damage to the nail plate causes abnormal nail, and ancestor or nail injuries normally regenerate nail (Rich 1998).
Keratin in the fingernail is an insoluble protein composed of approximately 25 layers of flat cells that are not alive (Murdan 2002) and keratin is a substance that constitutes the feathers, horns and wool of human hair, nails and algae, (Jones et al., 1997), and soft keratin and hard keratin (Kitahara and Ogawa, 1997; Lynch et al., 1986). Nails are composed of 10-20% of keratin and 80-90% of keratin (Cashman and Sloan 2010) and contain inorganic elements such as carbon, hydrogen, oxygen, nitrogen, sulfur and (Dittmar et al. 2008) (Fleckman 1997). The keratin fiber structure of the nail is related to the hardness of the nail (Forslind et al. 1976). In general, during the infancy, the nails are flexible and elastic, but the elderly are hard and brittle, The role of nail guards for reinforcement is important (Iran 2005).
In modern times, the nail is used as a means of aesthetic expression to extend the length of the nail or to express various shapes, pictures, and stereoscopic representations. Such methods include attaching artificial nails or extending cloth, And Liquid (Kim, JS and Choi, 2003). Butyl acetate and acrylates, including acetone, cause nail damage and contact dermatitis (Baran 2002). Chemicals used in removers can break nails and cause paronychia and onychodystrophy, including dry nail onycholysis and trachyonychia (Cashman et al. and Sloan 2010), repeated dehydration is known to cause lamellar dystrophy as a cause of nail detachment (Kerkhof et al. 2005).
OPI's original nail envy is a popular nail envy that protects nails from being peeled or cracked and contains a rich protein and calcium for a long, hard nail. As interest in well-being and health has increased, the beauty industry has also developed natural materials, and the importance of discovering natural materials is increasing. It is a species of Cedrela sinensis , a native tree of Korea and China. It is also used as a treatment for enteritis, dysentery and itching (Kang et al., 2003) , And phenolic compounds (Lee et al. 2006).
Numerous papers and patent documents are referenced and cited throughout this specification. The disclosures of the cited papers and patent documents are incorporated herein by reference in their entirety to better understand the state of the art to which the present invention pertains and the content of the present invention.
The present inventors have sought to find natural materials that can quickly restore the nail surface damaged by nail damage factors such as artificial nail surgery and strengthen the nails. As a result, it has been shown that the extract of Quang Zhi can quickly restore damaged keratinous tissues on the nail surface, alleviate the roughness of the increased nails, increase the reduced nail hardness, and increase the content of elements such as carbon, hydrogen, And it is very effective for restoration of nails, and thus the present invention has been completed.
Accordingly, it is an object of the present invention to provide a cosmetic composition for improving the nail condition, which comprises an extract of Aspergillus oryzae as an active ingredient.
The objects and advantages of the present invention will become more apparent from the following detailed description of the invention, claims and drawings.
According to one aspect of the present invention, there is provided a cosmetic composition for improving the nail condition comprising an extract of Cedrela sinensis as an active ingredient.
The Cedrela sinensis used in the present invention is a deciduous arboreous tree belonging to the mollusca. The stem is shallowly divided, reddish, thick reddish-brown, leaf is alternate and horny compound leaf, and small leaf is 10- 20, and it is basal or long oval. Flowers bloom in June, white, bell-shaped, and bisexual, hanging on cones. The fruit is oval with a capillary, the seed is elliptical, ripens in October, and has long wings on its upper part. It is also used as a treatment for enteritis, dysentery and itching, and it is known to contain phenolic compounds.
The seedling extract used in the present invention is an extract of whole seedlings selected from the group consisting of whole seedling or stem, root, leaf, flower, fruit, and seed.
The extract can be prepared by a variety of extraction methods known in the art, and is preferably prepared through a process of contacting an extraction solvent. Before or during the extraction step, the whole or part of the tree can be dried and / or ground.
In the present invention, the extraction solvent that can be used for obtaining the extract can be generally used in a natural material extraction process, and two or more different solvents may be mixed or used sequentially. Preferably, the extraction solvent of the present invention is selected from the group consisting of water, an anhydrous or a lower alcohol having 1 to 4 carbon atoms (methanol, ethanol, propanol, butanol), acetone, ethyl acetate, butyl acetate, dichloromethane (CH 2 Cl 2 ) , Hexane (Hexane) and 1,3-butylene glycol, and more preferably methanol, ethanol, n-hexane, dichloromethane, ethyl acetate or water may be used , Most preferably methanol and ethanol. It is obvious to those skilled in the art that the extract of the present invention has substantially the same effect as the extract obtained by the above-mentioned extraction solvent as well as the extract obtained by using other extraction solvent. The extraction process is completed by partially or completely removing the extraction solvent and partial removal means concentrating until an aqueous concentrate free of a significant amount of organic solvent is obtained, Can be obtained.
The extruded tree extract of the present invention can be prepared in powder form by an additional process such as vacuum distillation and freeze drying or spray drying. The extract prepared in powder form may be used in the cosmetic composition or may be used by being redispersed in a solvent or a mixed solvent. The solvent or mixed solvent in which the extract is dissolved or dispersed may be the same as or different from that used for the extraction.
The extract according to the present invention is contained in the cosmetic composition in an amount effective to obtain an improvement of the nail condition.
The extract according to the present invention is preferably contained in an amount of 0.0001 to 30% by weight, more preferably 0.001 to 20% by weight, based on the total weight of the composition.
The term "nail " as used herein includes not only nails but also claws, and is used interchangeably with the term" nail ".
As used herein, the term "improvement of the nail condition" includes strengthening of the nail, prevention of nail damage, and recovery of the damaged nail.
The extract of the present invention exhibits a restorative effect of closely contacting the separated and widened or excited keratin layer of the fingernail when applied to a damaged nail. It is also effective in nail restoration by alleviating the roughness of damaged nails, increasing hardness, and increasing the content of carbon, hydrogen, nitrogen, and sulfur in the damaged nails.
Therefore, when the cosmetic composition comprising the extract of the present invention is applied to a damaged nail, recovery of the nail can be promoted. In addition, it is effective not only for recovery of damaged nails, but also for prevention of nail damage and strengthening of nails through the above-mentioned action.
The cosmetic composition of the present invention may further comprise at least one cosmetically acceptable cosmetic composition selected from pigments, dyes, polymeric substances, surfactants, flow agents, perfumes, electrolytes, pH adjusting agents, antioxidants, preservatives, Or excipients.
The cosmetic composition of the present invention can be preferably prepared in the form of an external-use formulation directly applied to the nail surface. For example, it can be prepared in the form of a serum, lotion, emulsion, cream, aqueous gel, patch, makeup product, especially a composition applied to a nail, for example a nail glaze.
The features and advantages of the present invention are summarized as follows.
(i) The present invention provides a new use for the improvement of the nail condition of the Chinese cabbage extract.
(Ⅱ) Extracts of japanese japonica exhibit a restorative effect that tightly adheres again to the separated, widened, or hilarious keratinous layers present in damaged nails.
(Iii) In addition, japanese tree extracts ultimately restore damaged nails by reducing the roughness of damaged nails, increasing hardness, and increasing the content of reduced carbon, hydrogen, nitrogen, and sulfur elements in damaged nails.
(Iv) In addition, the extract is effective not only for the recovery of damaged nails but also for the prevention of nail damage and the strengthening of nails.
The present invention relates to a cosmetic composition for improving the condition of the nails, comprising an extract of Aspergillus oryzae as an active ingredient. The extract of Quercus mongolica has a restorative effect of tightly adhering the separated, flaccid and hilarious keratinous layer appearing in the damaged nail. It alleviates the roughness of the damaged nail, increases the hardness, and reduces carbon, hydrogen, nitrogen, Increases the content of sulfur element. In addition, it is effective not only for recovery of damaged nails, but also for prevention of nail damage and strengthening of nails through the above-mentioned action. The composition of the present invention can be developed as a cosmetic material for nail condition improvement.
Figure 1 shows the result of measuring the thickness of the nail. Panel A is a graph showing the results of the measurement of the thickness of the fingernail over a period of 6 weeks by time (week and week), and Panel B is a graph showing each group. N: untreated group as normal (no treatment), C: untreated group as control (control group), VC: vehicle control group treated with
2 is an electron micrograph of the nail surface before the artificial nail procedure. SEM, X 1000. N: little finger, C: ring finger, VC: middle finger, E1: index finger, E2: thumb finger.
Fig. 3 is an electron micrograph showing the damaged nail surface after 2 weeks of artificial nails except for the little finger. SEM, X 1000. N: little finger, C: ring finger, VC: middle finger, E1: index finger, E2: thumb finger.
FIG. 4 is an electron micrograph showing the surface of the nail after a sample is treated for 2 weeks on a nail damaged by an artificial nail procedure. SEM, X 1000. N: little finger, C: ring finger, VC: middle finger, E1: index finger, E2: thumb finger.
FIG. 5 is an electron micrograph showing the surface of the nail after treating the sample for 4 weeks with the nail damaged by the artificial nail procedure. SEM, X 1000. N: little finger, C: ring finger, VC: middle finger, E1: index finger, E2: thumb finger.
6 is an electron micrograph showing changes in the nail surface of the normal group (N) for 6 weeks. SEM, X 1000. A: Initial nail, B: Nail after 2 weeks, C: Nail after 4 weeks, D: Nail after 6 weeks.
7 is an electron micrograph showing changes in the nail surface of the control group (C) for 6 weeks. SEM, X 1000. A: Initial nail, B: Nail damaged by artificial nail for 2 weeks, C: Nail after 2 weeks after artificially damaged, and D: Nail after 4 weeks after artificially damaged.
Figure 8 is an electron micrograph showing the change of the nail surface for 6 weeks in the solvent control (VC). SEM, X 1000. A: Initial nail, B: Nail damaged by artificial nails for 2 weeks, C: Nail after 2 weeks after applying envy® nail strengthener, and Nail after 4 weeks after applying D: envy® nail strengthener.
FIG. 9 is an electron micrograph showing changes in the surface of the fingernail for 6 weeks in the experimental group 1 (E1). FIG. SEM, X 1000. A: Initial nail, B: Nail damaged by artificial nails for 2 weeks, C: Mixture of envy® nail strengthener and 5% oak wood methanol extract, nail after 2 weeks, D: envy® nail Nail after 4 weeks of application with a mixture of enhancer and 5% oak wood methanol extract.
10 is an electron micrograph showing changes in the nail surface of experimental group 2 (E2) for 6 weeks. SEM, X 1000. A: Initial nail, B: Nail damaged by artificial nails for 2 weeks, C: Mixture of envy® nail strengthener and 10% oak wood methanol extract, nail after 2 weeks, D: envy® nail Nail after 4 weeks of application with mixture of enhancer and 10% oak wood methanol extract.
11 shows the result of measuring the roughness of the nail. Panel A is a graph showing the roughness of the fingernail over a period of 6 weeks, and FIG. 6B is a graph showing the results of each group. N: Normal group, C: Control group, VC: Solvent control group, E1:
12 shows the result of measuring the hardness of the nail. Panel A is a graph showing the results of measuring the hardness of the fingernail over a period of 6 weeks according to time (week and week), and Panel B is a graph showing each group. N: Normal group, C: Control group, VC: Solvent control group, E1:
Fig. 13 shows the results of measurement of changes in the content of element (C, H, N, S) in the fingernail. Panel A is a graph showing the result of measurement of elemental change of the fingernail over a period of 6 weeks by time (week and week), and Panel B is a graph showing each group. N: Normal group, C: Control group, VC: Solvent control group, E1:
Hereinafter, the present invention will be described in more detail with reference to Examples. It is to be understood by those skilled in the art that these embodiments are only for describing the present invention in more detail and that the scope of the present invention is not limited by these embodiments in accordance with the gist of the present invention .
Example
Materials and Methods
1. Subject
Five women who were in their early 20s (21-24 years) with a good health condition and no living environment were evaluated for the last 3 months.
2. Reagents and instruments
The nail strengthening agent, OPI company original nail envy (USA), which is a popular product among the commercially available products, was used. Original nail envy is a nail-specific reinforcing agent for a complex nail, such as a weak, broken nail, a thin, peeled or cracked nail, and its ingredients are shown in Table 1. The thickness of the nails was measured using vernier calipers. The degree of damage of the fingernail was measured by a scanning electron microscope (SEM) using a scanning electron microscope (S-4300, Hitachi, Japan) and the degree of roughness was measured using a confocal laser scanning microscope (CLSM; confocal laser scanning microscope; LSM700, Carl Zeiss, Germany) Respectively. The hardness of the fingernail was measured by a micro-vickers hardness tester (MVK-H100A2, Mitutoyo, Japan). Elemental analysis was performed using an elemental analyzer (Flash 2000, Thermo Fisher, Italy) The component content (%) was measured.
3. Sample
In the present invention, a methanol extract of Cedrela sinensis methanol extract obtained from Korean plant extract bank was dissolved in a nail reinforcing agent.
4. Nail collection and treatment
The nail was cut from the part where the translucent free lance started. The length of the fingernail was 2 x 2 mm. First, the free flap was cut off at the beginning of the experiment and the free flap was cut at intervals of 2 weeks. The flap was taken 4 times over 6 weeks. The left hand was changed in hardness and the right hand was in thickness and morphological observation. Before the start of the experiment, 2 weeks, and 6 weeks after the start of the experiment, the free kite was cut and collected three times to measure the changes of the nails by elemental analysis.
4.1. Group classification
(Control), no treatment (vehicle), solvent control (VC): treatment with envy® enhancer after nail damage (normal control) (Experimental), experimental 2 (E2): methanol extract of Leaf Leaf Leaf after 5% + envy® enhancer treatment (experimental), experimental group 2 (experimental 2, E2) 10% + envy® enhancer treatment group (thumb).
4.2. Treatment method
After disinfecting the hands of the practitioner and the subject, the shape was gripped, and the cuticle was pushed back (cuticle push back) and buffed. After applying a tip suitable for the size of the nail, the tip was cut and the jaw was changed. Light glue was applied and volume was made with filler powder. After filing, it was buffed, applied with a gel glue and sprayed with a glue dryer. After buffing, I polished it. After one week attachment, artificial nail was removed and the same procedure was repeated twice a week once a week.
5. Measuring method
5.1. thickness
Sample nails were taken and thickness was measured using vernier calipers.
5.2. Damage degree
In order to observe the surface and cross-sectional shape of the fingernails, the nail samples were placed in an ependorf tube and dried at 37 ° C for 24 hours. The fingernail samples were cut into 2 mm and mounted on a specimen mount using C-tape After attaching, nail samples were attached. Specimen mounts were labeled and observed with a scanning electron microscope at a magnification of 1000X.
5.3. asperity
The CLSM is the most suitable optical microscope for capturing the three-dimensional structure of the sample. It focuses the laser light at one point of the sample and reads the color or brightness information at that point. When the entire sample is scanned, Can be obtained. It is possible to obtain a 2D or 3D image by visualizing the damage value by measuring the roughness value (Ra) after profile in the X and Y axis directions, Laser light can be transmitted through the specimen and measured to the roughness value of the surface and cross section. The sample was attached to a sample stub without pretreatment and then observed with a confocal laser scanning microscope at 200x magnification.
5.4. Hardness
The diamond indenter with a square weight of 136 ° at each face was pressed against the test surface under a constant test load of 0.1 kg or less and the hardness of the sample was measured with a micro Vickers hardness meter in terms of the load at that time and the area ratio of the concave portions generated in the nail .
Hv = P / AP: load, A: surface area of indenter
5.5. Elemental content
(C), hydrogen (H), nitrogen (N), and sulfur (S), which are the main components of the burned organic compound, are burned at a combustion temperature of 1800 ° C. Was passed through a reduction tube, and then sent to a detector, which was analyzed by an element analyzer to measure the element content (%) of the sample.
6. Data Analysis
The homogeneity was analyzed using the one-way ANOVA using the SPSS (version 20.0) statistical program, and the comparison between the groups was performed by Duncan's multiple range test. Statistical significance was tested at α = 0.05.
Experiment result
1. Thickness
The results of measuring the nail thickness are shown in Table 2 and Fig. Table 2 compares the results of measuring the thickness of the fingernail for 6 weeks between each taxon. All groups except the normal group (N) showed a decrease in thickness after artificial nails (2 weeks) and no difference between 4 weeks and 6 weeks after 2 weeks.
2. Damage degree
Comparisons of the damage of the nail surface between groups observed with a scanning electron microscope are shown in Table 3 and Figures 2-5. Before the artificial nail treatment, the surface of the natural nail looked smooth and hard with the layer in close contact, and the surface of the nail was clean. In all groups except the normal group (N), after 2 weeks of artificial nails, the surface of the nail was damaged due to the procedure, and the keratin layer was cracked and spread, and some were dissolved. Compared with the fact that the keratin layer of the N group is well adhered, the use of artificial nails and acetone lower the binding force of the keratin layer of the fingernail. The surface of the nail applied with the experimental material for 2 weeks after the damage of the fingernail was less than that of the control group (C) in the solvent control group (VC) and the experimental group 1 (E1) The binding force of the keratin layer was higher than that of the group. The surface of the nail applied with the test substance for 4 weeks after the injury was well adhered to the keratin layer which was damaged in the group C, the surface of the E2 group was even and uniform compared with the group E1, Seemed to be similar.
The changes in the degree of damage of the nail surface by the group for 6 weeks observed with a scanning electron microscope are shown in FIGS. 6 to 10. In the group N, the surface of the keratin layer was smooth and almost unchanged. In the group C, the keratin layer was separated due to the damage after the artificial nails were applied, and the damage was hardly recovered even after 4 weeks. The VC group showed some recovery after 4 weeks of application of the envy (R) enhancer after artificial nails, but the keratin layers were still dull and loose. On the other hand, in the E1 group, after the application of the experimental material for 4 weeks, the keratin layer was separated and the worn part was closely adhered. In the E2 group, the experimental material was applied for 4 weeks, The melted and dissolved keratin layer seemed to be recovered to a similar degree as before the procedure.
3. Roughness
The nail roughness observation results are shown in Table 4 and Fig. E2> E1> VC> C group (p <0.05) in the order of E2> E1> VC> C group after 4 weeks and 6 weeks after 2 weeks of artificial nails It looked.
4. Hardness
The results of measuring nail hardness are shown in Table 5 and FIG. E2> E1> VC> C group showed significant increase (p <0.05) in the order of E2> E1> VC> C group after 4 weeks and 6 weeks after artificial nails.
5. Elemental content
5.1. carbon
The results of measuring the carbon content changes are shown in Table 6 and Fig. E2> E1> VC> C group showed a significant increase (p <0.05) in the order of E2> E1> VC> C group after 6 weeks.
5.2. Hydrogen
The results of measuring the hydrogen content change are shown in Table 7 and FIG. In all groups except N, the hydrogen content decreased after artificial nails. E2> E1, VC> C group showed a significant increase (p <0.05) in the order of 6 weeks after 2 weeks.
5.3. nitrogen
The results of measuring the nitrogen content changes are shown in Table 8 and FIG. Nitrogen content decreased after artificial nails in all groups except N, and E2> E1 and VC> C groups showed a significant increase (p <0.05) in the order of 6 weeks after 2 weeks.
5.4. sulfur
The results of the measurement of sulfur content changes are shown in Table 9 and FIG. In all groups except group N, the sulfur content decreased after artificial nails. E2, E1> VC> C group showed a significant (p <0.05) increase in the order of 6 weeks after 2 weeks.
6. Review
Fingernails have been considered important for centuries for cosmetic purposes as well as physiological roles (Barnett and Scher 1992). The leaf of oak tree contains vitamins C in addition to minerals such as protein, carbohydrate, lipid, fiber, iron, phosphorus and other specific ingredient quercitrin, and calcium is contained in 946mg per 100g dry weight of leaf And it has a high calcium content which is comparable to that of a general high-calcium food such as kelp (Yong-Bong Han, 2003). The nail has a thickness of 0.25-0.6 mm (Murdan 2002). Acetone is a volatile, odorless, flammable organic solvent (Kalapos 2003) used in artificial nail surgery. Kang, Chang-hee and Gang-sang (2011) reported that acetone among acetone, ethyl acetate, and butyl acetate has the highest nail damage. The nail thickness was compared before and after artificial nails to evaluate the degree of nail damage by acetone. The nail thickness was thinned twice after artificial nails for 2 weeks in both C, VC, E1, and E2 groups compared to before the procedure. The nail thickness changes after 2 weeks and 4 weeks after application of artificial nails It was not. Shin et al. And Lee Jung-min (2010) reported that acetone is capable of dehydrating and chemically modifying proteins on the surface due to dehydration, and that nail protein is continuously eliminated during repeated artificial nail treatment. In addition, it was confirmed that the thickness of the nails was thinner when the soft gel was removed after the soft gel treatment, which was removed by acetone, compared to the hard gel which is thinned according to the number of procedures in the gel procedure and compared with the hard gel to be removed by grinding. Chen et al. (2012) reported that the use of acetone also reduced the thickness of the nail.
As a result of scanning electron microscope, the surface of the natural nail before the artificial nail was smooth and hard with the layer adhered, the surface was clean and the condition of the nail was healthy. Group C, which had not undergone any treatment for 4 weeks after the injury, was severely injured and had a poor natural resilience. After 4 weeks of injury, the VC group treated with envy® enhancer showed recovery and keratinization . For 4 weeks after the injury, the E1 group, which was coated with 5% methanol extract of enriched leaves and envy ® enhancer, relaxed the horny part of the damaged keratin layer. During the 4 weeks after the injury, 10% methanol extract of enchilada leaves and envy Ⓡ group showed the fastest recovery pattern in the experimental group, indicating that the methanol extract of Leuconostoc japonica has the effect of restoring the damaged keratin layer.
In a previous study that observed morphological damage to the fingernail, Kim and Jeong-suk (2003) found that when nail-tip management was used compared to natural nails that did not manage nail tips at all, ), The morphological damage after nail tip primary care and subsequent secondary treatment was more severe in acetone-immersed nails. In the study of Lee et al. (2009), the surface of the nail that was left untreated naturally for 2 weeks after artificial nail treatment was very rough and severe dehydration. The surface of the nail reinforcements A, B, But it was not smooth, but it showed more improvement than nails left untreated. In addition, Lee et al. (2009) suggested that nail reinforcements temporarily strengthen the nail structure and oil, moisturizing, and protein components can be effective among various useful components of the nail reinforcement. On the other hand, quercetin is used as a hair care product (Reddy et al. 2011), and the leaves of oak tree are phenol such as catechin, quercetin, quercitrin, isoquercitrin, (Lee et al., 2006). Considering these reports, morphological damage caused by the use of acetone during the removal of artificial nails after the second artificial nail continuous second procedure was severe in the present invention. Of the protein and moisturizing ingredients of the nail surface is thought to have given the recovery effect.
To evaluate the degree of damage of the nail using a more objective index than the morphological observation, the roughness value was increased in all groups after 2 times of artificial nail treatment for 2 weeks by the confocal laser scanning microscope. The roughness values were decreased 16.9, 13.9, 10.1, 3.0% in E2, E1, VC, and C after 2 weeks of application and 30.7, 23.9, 17.7, and 5.7% after 4 weeks of application , And E2> E1> VC group (p <0.05). These results suggest that the surface roughness of the nail damaged by the acetone application is reduced by applying the methanol extract of the leaves of the leaves to the keratin layer.
The structure of the fingernails is characterized by hardness and flexibility (Kerkhof et al. 2005) and the composition of the keratin fibers is related to the hardness of the fingernails (Forslind 1976). Hardness indicates whether the fingernail is easily scratched or nicked (Baran and Schoon 2004). As a result of measuring the hardness value, the hardness value of all groups decreased after 2 times of artificial nails for 2 weeks. Hardness values were increased by 27.4, 25.7, 21.3, and 0.9% in E2, E1, VC, and C groups, respectively, and by 50.5, 41.7, 34.5, and 1.4% after 4 weeks of application of the test substance, respectively E2> E1> VC group (p <0.05). Cystine in the nail is involved in many metabolisms, and sulfur-containing amino acids can affect nail growth and hardness (Iorizzo et al. 2007). In recent years, nail strengtheners have been replaced by formaldehyde, and ingredients such as biotin, calcium, keratin, and vitamins are known to have a good effect on nail strength as well as length (Moossavi and Scher 2001) . Therefore, in this study, it is considered that the damaged nails caused by the use of acetone give reinforcement effect to the nails due to the application of the nail strengthener and the methanol extract of the oak leaf.
Nails have been reported to contain elemental components of 45% carbon, 7% hydrogen, 15% nitrogen, 14% oxygen, 3% sulfur (Dittmar et al. 2008) and 8-10% inorganic components (Fleckman 1997). As a result of analysis of elemental contents, carbon, hydrogen, nitrogen and sulfur contents were decreased after 2 times of artificial nails for 2 weeks. Carbon content increased 3.7, 2.3, 1.5, 0.6% in E2, E1, VC, and C groups after 4 weeks of application of artificial nails compared with that of artificial nails. E2> E1> VC group p <0.05). Nails are more likely to break when water content is low (Baran and Schoon 2004) and the moisture content of normal nails varies by 18-20% (Baden, 1970), depending on relative humidity. The hydrogen content increased 3.3, 2.7, 2.0, 0.8% in E2, E1, VC, and C groups at 4 weeks after application of artificial nails. E2> E1, VC group p <0.05). It is considered that the moisturizing power of oak tree leaves is helpful for recovery of damaged nails. Nitrogen content increased 2.4, 1.5, 1.1, 0.2% in E2, E1, VC, and C groups after 4 weeks of application of artificial nails, p <0.05). Sulfur content increased 14.3, 11.3, 10.2, and 3.5% in E2, E1, VC, and C groups at 4 weeks after application of artificial nails, and E2 and E1> VC groups p <0.05). Schumacher et al. (2009) reported that harmful components such as acetone reduce the sulfur content of the nails and reduce the content of sulfur-containing proteins by breaking the structure of the alkali and acid components in the nails. It was confirmed that the methanolic extracts of Leucigenia japonica used in the present invention contained carbon, hydrogen and nitrogen contents of 40.6, 6.5 and 0.2%, respectively. Thus, application of methanol extract of Leucigenia japonica L. leaves seems to affect the increase of these components .
According to the results of the experiment of the present invention, it was possible to confirm the damage of the nails by reducing the thickness of the artificial nails, damaging the keratin layer, increasing the roughness, decreasing the hardness and decreasing the element content. After 4 weeks of application, The 10% extract group showed the highest resilience. This suggests that the methanol extract of Leuconostoc japonica leaf is effective in the recovery of damaged nails and may be useful as a cosmetic material for reinforcing damaged nails.
While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the same is by way of illustration and example only and is not to be construed as limiting the scope of the present invention. Accordingly, the actual scope of the present invention will be defined by the appended claims and their equivalents.
Claims (7)
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20130043112A KR20140125217A (en) | 2013-04-18 | 2013-04-18 | Cosmetic Composition for Improving Nail Surface Condition Comprising Extract from Cedrela sinensis as Active Ingredient |
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| KR20130043112A KR20140125217A (en) | 2013-04-18 | 2013-04-18 | Cosmetic Composition for Improving Nail Surface Condition Comprising Extract from Cedrela sinensis as Active Ingredient |
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| KR20140125217A true KR20140125217A (en) | 2014-10-28 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20230001671A (en) * | 2021-06-29 | 2023-01-05 | 동의대학교 산학협력단 | Anti-inflammatory and antibacterial composition comprising a Cedrela sinensis extract as an active ingredient |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20230001671A (en) * | 2021-06-29 | 2023-01-05 | 동의대학교 산학협력단 | Anti-inflammatory and antibacterial composition comprising a Cedrela sinensis extract as an active ingredient |
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