KR20140102875A - Preparation and stabilization of idebenone encapsulated with skin lipids complex and moisturizing oil and its application of anti-aging cosmetics - Google Patents

Abstract

The present invention provides a method for producing a cosmetic material for reducing wrinkles including an idebenone capsule encapsulated with a skin lipid composite and moisturizing oil. The cosmetic material contains 100 parts by weight of idebenone and 10-500 parts by weight of each of a skin lipid composite and moisturizing oil with respect to 100 parts by weight of idebenone. The skin lipid composite encapsulates the moisturizing oil in which the idebenone is dissolved. The average diameter of a particle in which the idebenone is encapsulated with the skin lipid composite and moisturizing oil is 100 to 1500 micrometers. The idebenone capsule encapsulated with a skin lipid composite and moisturizing oil of the present invention can stabilize idebenone at very low cost compared to existing nano emulsion or nano liposome techniques used for stabilizing idebenone.

Description

FIELD OF THE INVENTION The present invention relates to a method for preparing a cosmetic composition for wrinkle improvement comprising an ibuprofen capsules encapsulated in a skin lipid complex and a moisturizing oil and a method for stabilizing ibuprofen,

The present invention relates to a method for preparing a wrinkle-improving cosmetic composition comprising an ibebenone capsule encapsulated in a skin lipid complex and a moisturizing oil, and a method for stabilizing ibebenone. More particularly, the present invention relates to a method for stabilizing ibebenone, Claims: 1. A cosmetic composition for improving wrinkles comprising an imidobenone capsule encapsulated in a skin lipid complex and a moisturizing oil prepared by macroscopicity using recrystallization property and further comprising an imidobenone capsule encapsulated in a skin lipid complex and a moisturizing oil, ≪ / RTI >

From the moment humanity has established a system of perception and culture, mankind has made great efforts to delay or solve it with great interest in aging and disease. In particular, skin aging symptoms such as decreased skin elasticity and fine wrinkles appearing as a result of aging have been of great concern to women and have been of great concern for delays and solutions.

As a matter of fact, over the last decade or so, their skin has become much younger and the clean, smooth skin that they had in their late teens and early twenties has become a major concern for many women, Have begun to take an interest in improving their skin condition and preventing aging, there has been an explosion in interest and demand for cosmetics containing not only effective ingredients against anti-aging but also anti-aging and anti- Wrinkles and Elasticity Improvement Cosmetics are a big part of the skincare market.

In general, aging of skin is divided into severe aging caused by natural aging, environmental pollution, frequent exposure to ultraviolet rays, and environmental aging promoted by free radicals, which are externally exposed to the physiological function of the human body. Substances such as IDEBENONE, retinol and its derivatives, adenosine, vitamin C, collagen and various kinds of peptides, proanthocyanidin, epigallocatechin (EGCG) and other polyphenols, And triterpenoids including an acid, an oleanolic acid, and the like.

In addition, various components extracted from various plants and marine animals and plants and complexed with them have been researched and developed and used in cosmetic compositions for improving wrinkles.

Idebonon is a ubiquinone antioxidant present in living cell membranes and is similar to Coenzyme Q10, which is mainly involved in ETC (Electron Transfer Chain) involved in the production of ATP (Adenosine triphosphate), which is a cell energy in mitochondria As a chemical substance with a structure, the chemical name is 2,3-dimethoxy-5-methyl-6- (10-hydroxydecyl) -1,4-benzoquinone ) -1,4-benzoquinone] and a molecular weight of 338.44, which is known as a refined yellow crystalline powder material obtained mainly by chemical synthesis (see FIG. 1).

In addition, it has been reported that ibebenone has very good efficacy in aging as a medicinal product and a cosmetic product according to a known research paper applied for pharmaceutical or cosmetic use [A controlled study of 2 doses of idebenone in the treatment of Alzheimer's disease, Neuropsychobiology, 1997; Idebenone improves cerebral mitochondrial oxidative metabolism in a patient with MELAs, Neurology, 1996; Oral administration of idebenone, a stimulator of NGF synthesis, Neuroscience letter, 1993; Mitochondrialencephalomyopathy (MELAS), pathological study and successful therapy with coenzym Q10 and idebenone, Journal of Neuroscience, 1989].

In addition, itbenone is involved in ETC (Electron Transfer Chain) related to the production of ATP (Adenosinetriphosphate), which is a cell energy in mitochondria, and is effective for cell activation. In the mitochondria, ROS (Reactive Oxygen Species) Alzheimer ' s disease, which is a degenerative neurological disease that is problematic due to aging by promoting nerve growth factor (NGF) medically, preventing cerebrovascular disease (Cerebrovascular < RTI ID = disease) and liver disease have been reported.

Therefore, studies on the development of cosmetics and medicines using Idebonon in the future are being actively carried out. However, the ibebenone has a complex structure such as a quinone group, a saturated hydrocarbon group and a hydroxyl group. The yellow crystalline powder ibdenon has a very high polarity, and the raw material itself It is not stable because it is easily changed color when exposed to the external environment such as light, air, water, heat, etc., and its preservability is poor.

In order to solve such a problem, a method of emulsifying or liposomizing an effective substance is generally known in order to stabilize the above-mentioned effective substances and to increase the skin transferring effect. Among them, small particles of 1 micro or less Microcapsules or the like may be prepared by adding a surfactant at a suitable temperature to obtain fine particles using a relatively high amount of the surfactant and using a minimal amount of a surfactant but adding a high energy of a high- And a method of obtaining fine nanoparticles of 50 to 300 nm by using a special equipment which can be used as a catalyst.

However, the biggest problem in manufacturing nano-particles such as nano-emulsion or nano-liposome is that expensive equipment and a large cost of depreciation are consumed, so that manufacturing cost is generally much higher than conventional emulsification techniques The process is also difficult to mass-produce, and there is an economical problem such as a long manufacturing time. Therefore, it has been mostly used only for manufacturing very expensive cosmetic products, and since nano-encapsulated ibebenone has been mainly used for cosmetics having a certain viscosity such as lotion, cream, etc. Despite the advantages of the above-mentioned component effective effect and the great advantage in drug delivery efficiency, it has been difficult to apply it universally in a real industry. In addition, application of nano-encapsulated idebene has been limited to formulations such as skins and ampoules, which are solubilized formulations, and it is difficult to be solubilized, so that it has been difficult to use a large amount of solubilizing agent.

Numerous papers and patent documents are referenced and cited throughout this specification. The disclosures of the cited papers and patent documents are incorporated herein by reference in their entirety to better understand the state of the art to which the present invention pertains and the content of the present invention.

1. KR Patent Publication 2007-0065509 (cosmetic composition for improving wrinkles containing idebone and idebenone for improving wrinkles) 2. KR Patent Publication 2006-0047328 (Wrinkle-improving cosmetic composition containing idebenone nanocapsules and a process for producing the same) 3. KR Patent Publication 2006-0002084 (base composition with high concentration of ibebenone nanocapsulated, method for producing the same, and cosmetic composition containing the same)

The present inventors have found that the polarity of ibedenone, which is a yellow crystalline powder phase, is very high, and the raw material itself is stable, such as being easily changed in color when exposed to the external environment such as light, air, water and heat, I tried to do my best to solve this problem.

As a result, the present inventors have found that it is possible to stabilize ibebenone in a very simple and economical manner in comparison with the conventional nano-emulsion or nanoliposome method when it is incorporated into a skin lipid complex after dissolving ibebenone in a moisturizing oil.

Accordingly, it is an object of the present invention to provide a method for stabilizing idebenone using a skin lipid complex and a moisturizing oil, and an idebenone macrocapsule encapsulated in a skin lipid complex and a moisturizing oil.

Further, the present invention is to provide a wrinkle-improving cosmetic comprising a skin lipid complex and an imidobenzene capsule encapsulated in a moisturizing oil, and a manufacturing method thereof.

Other objects and advantages of the present invention will become more apparent from the following detailed description of the invention, claims and drawings.

The present invention provides a method for preparing a wrinkle-improving cosmetic composition comprising an imidobenone capsule encapsulated in a skin lipid complex and a moisturizing oil, and a method for stabilizing idenone.

The present inventors have found that the polarity of ibedenone, which is a yellow crystalline powder phase, is very high, and the raw material itself is stable, such as being easily changed in color when exposed to the external environment such as light, air, water and heat, I tried to do my best to solve this problem.

As a result, the present inventors have found that it is possible to stabilize ibebenone in a very simple and economical manner in comparison with the conventional nano-emulsion or nanoliposome method when it is incorporated into a skin lipid complex after dissolving ibebenone in a moisturizing oil.

According to one aspect of the present invention, the present invention provides a composition comprising 100 parts by weight of Idebenone, a skin lipid complex and a moisturizing oil, wherein the amount of skin lipid complex and moisturizing oil is 10-500 parts by weight, , The skin lipid complex encapsulates the moisturizing oil in which the ibebenone is dissolved, and the average diameter of the covering particles in which the ibebenone is in contact with the skin lipid complex and the moisturizing oil is 100 to 1500 μm And an i-DEBENON macrocapsule.

The term " idebenone " in the present specification is a synthetic derivative of coenzyme Q10, and it is involved in the production of adenosine triphosphate (ATP), which is a cell energy, like Coenzyme Q10. Specifically, mitochondria electron chain Transfer Chain. It also inhibits the activity of ¹ O ₂ (singletoxygen), a free radical that is harmful to the skin, and prevents cell damage, lipid peroxidation, . ≪ / RTI > In addition to the above-mentioned effects, it has also been shown that fibroblast increases collagen biosynthesis and inhibits the collagenase activity of collagenase, thereby improving skin wrinkles and improving skin elasticity .

As used herein, the term "enclosing" refers to a phenomenon in which other chemical species (guests) of a suitable size and shape are housed (enclosed) in a 1-3-dimensional space formed by a chemical species (host) .

According to a preferred embodiment of the present invention, the skin lipid complex and the moisturizing oil may include 10-500 parts by weight, respectively, based on 100 parts by weight of the imidobenone, and more preferably, And 20 to 200 parts by weight with respect to 100 parts by weight of idebone.

When the skin lipid complex and the moisturizing oil are used in an amount of 10 parts by weight or less based on 100 parts by weight of the above-mentioned idebone, it is difficult to dissolve idebenone in a moisturizing oil, and even if it is dissolved in a moisturizing oil, The content of the skin lipid complex and the moisturizing oil is so low that it can not sufficiently collect ibebenone, and thus the water phase and the oil phase are separated and ibebenone is precipitated.

When the content of the skin lipid complex and the moisturizing oil is more than 500 parts by weight based on 100 parts by weight of the above-mentioned idebone, the effect of reducing the wrinkle is insufficient and the excessive amount of the skin lipid complex and moisturizing oil The crystallized particles may aggregate together to form a large mass and thus may not be dispersed evenly in the water phase. In the recrystallization process of the oil phase containing ibebenone with an excessive amount of moisturizing oil, the skin lipid complex and the moisturizing oil And the oil are not collected but are drained out, and the oils flocculate and float together, so that it is exposed to the outside and stabilization is not achieved.

According to a preferred embodiment of the present invention, in the present invention, the skin lipid complex is preferably selected from the group consisting of pentaerythrityl tetrahexyl hexanoate, dipentaerythritol hexahydroxystearate / hexa stearate / hexa roginate, cholesteryl Hydroxystearate, behenyl alcohol, higher alcohol, shea butter, mango butter and mixtures thereof, more preferably selected from the group consisting of pentaerythritol tetrahexyl hexanoate, dipentaerythritol hexa It may be a mixture of hydroxystearate / hexa stearate / hexa rognate, cholesteryl hydroxystearate, behenyl alcohol, higher alcohol, shea butter and mango butter, and most preferably based on the total weight of the mixture 40 to 60% by weight of pentaerythrityl tetrahexyl hexanoate, dipentaerythritol hexa 20 to 30% by weight of dodecoxy stearate / hexastearate / hexa rosinate, 10 to 20% by weight of cholesteryl hydroxystearate, 5 to 15% by weight of behenyl alcohol, 0.1 to 2% by weight of high- 1 to 2 wt% and mango butter 1 to 2 wt%.

According to a preferred embodiment of the present invention, the moisturizing oil is preferably selected from the group comprising squalane, vegetable squalane, hydrogenated polydecene, hydrogenated poly (C6-14 olefins) and mixtures thereof.

According to another aspect of the present invention, the present invention provides a method of making a wrinkle-improving cosmetic composition comprising the steps of:

(a) uniformly dispersing water, a humectant, and a carbomer in a vacuum emulsification vessel, followed by heating to 70-80 占 폚 to prepare a water phase;

(b) heating and mixing iridobonone, skin lipid complex, and moisturizing oil to an oily dissolving tank at 70 to 90 캜 to prepare an oily portion;

(c) cooling the water phase of step (a) to 30-50 占 폚;

(d) injecting the oily phase of the step (b) into the vacuum emulsification tank of the step (c), followed by stirring and dispersing; And

(e) cooling the vacuum emulsification tank of step (d) to 20 to 50 캜 to form an idebenone macrocapsule encapsulated in a skin lipid complex and a moisturizing oil.

According to a preferred embodiment of the present invention, the carbomer of step (a) is preferably selected from the group comprising carbomer, acrylate / C10-30 alkyl acrylate crosspolymer, carboxyvinyl polymer, and most preferably, Carbomer, acrylate / C10-30 alkyl acrylate crosspolymer, carboxyvinyl polymer, based on the total weight of the cosmetic composition.

The cosmetic composition of the present invention may contain components other than the above-mentioned skin lipid complex and imidobenzene encapsulated in the moisturizing oil. According to an embodiment of the present invention, the cosmetic composition of the present invention is obtained from the group comprising glycerin, butylene glycol, polyoxyethylene hydrogenated castor oil, tocopheryl acetate, citric acid, panthenol, squalane, sodium citrate and allantoin Further comprising at least one auxiliary component selected from the group consisting of glycerin, polyoxyethylene hydrogenated castor oil, tocopheryl acetate, squalane and sodium citrate, and at least one auxiliary ingredient selected from the group consisting of butylene glycol, citric acid, panthenol and allantoin And most preferably at least one component selected from the group consisting of glycerin, butylene glycol, polyoxyethylene hydrogenated castor oil, tocopheryl acetate, citric acid, panthenol, squalane, sodium citrate and allantoin .

Since the cosmetic composition of the present invention is basically applied to the skin, it can be provided with reference to the cosmetic composition of the related art. For example, it can be formulated into a solution, a suspension, an emulsion, a paste, a gel, a cream, But is not limited thereto. More specifically, it can be manufactured as a flexible lotion, a nutritional lotion, a nutritional cream, a massage cream, an essence, and an eye cream formulation.

When the formulation of the present invention is a solution or an emulsion, a solvent, a dissolving agent or an emulsifying agent is used as a carrier component, and examples thereof include water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, , 3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan fatty acid esters.

When the formulation of the present invention is a suspension, a carrier such as water, a liquid diluent such as ethanol or propylene glycol, a suspension such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, Crystalline cellulose, aluminum metahydroxide, bentonite, agar, or tracant may be used.

The features and advantages of the present invention are summarized as follows:

(a) 100 parts by weight of Idebenone, a skin lipid complex and a moisturizing oil, wherein the amounts of the skin lipid complex and the moisturizing oil are 10-500 parts by weight, respectively, And the moisturizing oil encloses the above-mentioned idebenone. The average diameter of the covering particles enclosing the above-mentioned idebenone with the skin lipid complex and the moisturizing oil is 100 to 1,500 탆 and the skin lipid complex and the moistening oil The present invention provides a method for producing a cosmetic product for improving wrinkles,

(b) The ibebenone macrocapsule encapsulated in the skin lipid complex and moisturizing oil of the present invention has an advantage of stabilizing ibebenone at a very low cost compared to the nano-emulsion or nanoliposome technology used for stabilizing ibebenone to provide.

(c) The ibebenone macrocapsule encapsulated in the skin lipid complex and moisturizing oil of the present invention has an extremely high stability, and thus provides an advantage that ibebenone is not precipitated under severe conditions such as high temperature treatment.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a conceptual diagram of an idebenone macrocapsule encapsulated in a skin lipid complex and a moisturizing oil of the present invention.
FIG. 2 is a photograph of a digital camera of an idebenone macrocapsule particle encapsulated in a skin lipid complex and a moisturizing oil of the present invention.

Hereinafter, the present invention will be described in more detail with reference to Examples. It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not to be construed as limiting the scope of the present invention. It will be self-evident.

Example

Throughout this specification, "%" used to denote the concentration of a particular substance is intended to include solids / solids (wt / wt), solid / liquid (wt / The liquid / liquid is (vol / vol)%.

Manufacturing example  : To skin lipid complex and moisturizing oil Enclosed Idebenon  Containing Macro Capsules Cosmetics  Preparation of composition

The cosmetic composition was prepared by recrystallization of the skin lipid complex of the present invention with the composition of the following Table 1, and then encapsulating the skin lipid complex and moisturizing oil to obtain stabilized ibebenone macrocapsules. A more specific production method is as follows.

The water phase including carbomer (CARBOPOL, Germany, Beef Goodrich) was uniformly dispersed in a vacuum emulsification tank and heated to 70-80 占 폚. After that, IDEBENOIN (Taiwan), skin lipid complex and moisturizing oil (PENTAERYTHRITYL TETRAETHYLHEXANOATE), DIPENTAERYTHRITYL HEXAHYDROXYSTEARATE / HEXASTEARATE (HEXASTEARATE ), HEXAROSINATE, CHOLESTERYL HYDROXYSTEARATE, BEHENYL ALCOHOL (Hwacheon, Korea), CETYL ALCOHOL (Germany, Cognis), Shea butter (SHEA BUTTER, GUSTAVHEESS, Germany) and MANGIFERA INDICA (MANGO SEED BUTTER, ARJUNA)}, oil {squalane (Kishimoto, Japan), vegetable squalane (PHYTOSQUALANE, CRMINTERNATIONAL / SPEC- CHEM ) And HYDROGENATED POLY (C6-14 OLEFIN, EXXONMOBILCHEMICAL)) were added to an emulsion tank and uniformly dispersed and heated to 75 to 80 ° C. The completely dissolved and hydrated water phase was cooled to 45 캜. The oily phase heated at 75 to 80 캜 was charged into a vacuum emulsification vessel containing the water phase, and the paddle was stirred at a rotation speed of 15 to 30 rpm to be uniformly dispersed. The uniformly dispersed cosmetic material was cooled to 32 캜 to recrystallize a moisturizing oil containing a skin lipid complex and idebenone. Finally, a neutralizing agent was added to the mixture to neutralize and thicken it. Then, the mixture was degassed by applying a vacuum to cover the skin lipid complex and the moisturizing oil to prepare a cosmetic composition comprising the stabilized idebenone macrocapsule.

Preparation of a cosmetic composition comprising an imidobenone macrocapsule encapsulated in a skin lipid complex and a moisturizing oil division ingredient
(weight%) Example 1 Example 2 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 Comparative Example 7 Comparative Example 8 Water top water 89.93 88.64 90.03 89.03 90.03 84.08 91.88 85.93 90.13 90.05 Moisturizer 6.6 6.6 6.6 6.6 6.6 6.6 6.6 6.6 6.6 6.6 Carbomer 0.16 0.08 0.16 0.16 0.16 0.16 0.16 0.16 0.06 0.32 Floating Idebenon 0.1 0.5 0.01 0.9 0.1 0.1 0.1 0.1 0.1 0.1 Skin lipid complex 0.15 0.2 0.15 0.15 0.05 6 0.15 0.15 0.15 0.15 Moisturizing oil 2 2 2 2 2 2 0.05 6 2 2 Additive part corrector 0.16 0.08 0.16 0.16 0.16 0.16 0.16 0.16 0.06 0.1 Preservative part complex
antiseptic 0.4 0.4 0.4 0.4 0.4 0.4 0.4 0.4 0.4 0.4

Experimental Example  : To skin lipid complex and moisturizing oil Enclosed Idebenon  Evaluation of physical properties of macro capsules

Experimental Example  1-1: In skin lipid complex and moisturizing oil Enclosed Idebenon  Check the shape of macro capsules

The cosmetic composition comprising the skin lipid complex prepared by the method of Example 1 and the ibebenone macrocapsule encapsulated in the moisturizing oil was confirmed to be in the form of an ibebenone macrocapsule encapsulated in a skin lipid complex and a moisturizing oil using a digital camera . Specific results are shown in Fig. In Fig. 2, it can be seen that the macrocapsule particles of the present invention encapsulate the skin lipid complex and the moisturizing oil.

Experimental Example  1-2: HPLC  Through analysis Idebenon Inclusion rate  Measure

Liquid chromatographic analysis was performed to determine the inclusion rate of imidobenone in skin lipid complexes and moisturizing oils. In a stainless steel tube with an internal diameter of 4.6 mm and a length of 15 cm , for a liquid chromatograph of 5 μm Using a standard column packed with octadecylsilylated silica gel , the sample was injected at a flow rate of 1.5 ml / min and analyzed at a wavelength of 278 nm.

Measurement of inclusion rate of imidobenzene embedded in skin lipid complex and moisturizing oil content(%) yield(%) Inclusion rate (% Example 1 0.1% 0.098% 98.0% Example 2 0.5% 0.485% 97.0%

conclusion

In the case of Example 1 and Example 2, recrystallization of the skin lipid complex and the moisturizing oil was stably performed to effectively encapsulate and stabilize ibebenone, and the ibebenone macrocapsules encapsulated in the formed skin lipid complex and moisturizing oil were uniformly dispersed It was confirmed that it was stable for a long period under severe conditions such as 50 ° C and 40 ° C.

However, if less than 0.01% by weight of ibebenone is used as in Comparative Example 1, the effect of improving wrinkles is insignificant and is not worthy as a wrinkle-improving cosmetic. If more than 0.8% by weight of ibebenone is used as in Comparative Example 2, it is difficult to dissolve in moisturizing oil. If the content of the skin lipid complex is less than 0.1% by weight as in Comparative Example 3, it is recrystallized as very small particles and the imbene and moisturizing oil can not be enclosed sufficiently, so that the water phase and the oil phase are separated and ibebenone is precipitated , And when the content of the skin lipid complex exceeds 5.0 wt% as in Comparative Example 4, the excessive recurrence of the skin lipid complex and the recrystallized particles by the moisturizing oil are aggregated together to form a large lump, . When the content of the moisturizing oil used as in Comparative Example 5 was less than 0.1% by weight, the warmed idenone, the skin lipid complex and the moisturizing oil were added to the water, , The stabilized idebenone macrocapsules were not formed. When the content of the moisturizing oil is 5.0% by weight or more as in Comparative Example 6, in the recrystallization process of the oil phase containing idebanone, both the edebenone and the moisturizing oil are not encapsulated in the skin lipid complex, During the recrystallization of lipid complexes and moisturizing oils, ideneone and moisturizing oil were exposed to the outside to stabilize them. When the content of the carbomer in the water phase was not more than 0.01% by weight as in Comparative Example 7, viscosity was not formed, and the oil phase dispersed upon dispersion of the oil phase containing ibuprofen, skin lipid complex and moisturizing oil rapidly aggregated together, There is a problem that it is impossible to prepare a stabilized idebenone macrocapsule through recrystallization of a complex and a moisturizing oil. When the carbohydrate content of the aqueous phase is 0.3% by weight or more as in Comparative Example 8, the viscosity of the aqueous phase is too high, Lipid complexes and moisturizing oils were broken, it was found that the icedon macroparticles formed by the high shear were broken during the cooling process.

Claims (8)

100 parts by weight of Idebenone, a skin lipid complex and a moisturizing oil,
The amount of the skin lipid complex and the moisturizing oil is 10-500 parts by weight,
The skin lipid complex includes the moisturizing oil in which the above-mentioned debenone is dissolved,
Wherein the dissolved ibebenone is encapsulated in a skin lipid complex and a moisturizing oil having an average diameter of 100 to 1500 mu m of the covering particles in which the skin lipid complex and the moisturizing oil are embedded.
The method according to claim 1,
Wherein said skin lipid complex is selected from the group consisting of pentaerythritol tetrahexyl hexanoate, dipentaerythritol hexahydroxystearate / hexa stearate / hexa rognate, cholesteryl hydroxystearate, behenyl alcohol, , Mango butter, and mixtures thereof, and an idebenone macrocapsule encapsulated in a moisturizing oil.
3. The method of claim 2,
Based on the total weight of the mixture, 40 to 60% by weight of pentaerythrityl tetrahexyl hexanoate, 20 to 30% by weight of dipentaerythritol hexahydroxystearate / hexa stearate / hexa rosinate, Characterized in that it comprises 10 to 20% by weight of rehydrated hydroxy stearate, 5 to 15% by weight of behenyl alcohol, 0.1 to 2% by weight of higher alcohol, 1 to 2% by weight of shea butter and 1 to 2% by weight of mango butter. Lipid complexes and moisturizing oils.
The method according to claim 1,
Wherein the moisturizing oil is selected from the group comprising squalane, vegetable squalane, hydrogenated polydecene, hydrogenated poly (C6-14 olefin), and mixtures thereof. Beneon macro capsules.
A method for preparing a cosmetic composition for improving wrinkles comprising the steps of:
(a) uniformly dispersing water, a humectant, and a carbomer in a vacuum emulsification vessel, followed by heating to 70-80 占 폚 to prepare a water phase;
(b) heating and mixing iridobonone, skin lipid complex, and moisturizing oil to an oily dissolving tank at 70 to 90 캜 to prepare an oily portion;
(c) cooling the water phase of step (a) to 30-50 占 폚;
(d) injecting the oily phase of the step (b) into the vacuum emulsification tank of the step (c), followed by stirring and dispersing; And
(e) cooling the vacuum emulsification tank of step (d) to 20 to 50 캜 to form an idebenone macrocapsule encapsulated in a skin lipid complex and a moisturizing oil.
6. The method of claim 5,
Wherein the carbomer of step (a) is selected from the group consisting of carbomer, acrylate / C10-30 alkyl acrylate crosspolymer, carboxyvinyl polymer, and mixtures thereof.
The method according to claim 6,
Wherein the carbomer comprises 0.01 to 0.3% by weight based on the total weight of the cosmetic composition.
6. The method of claim 5,
Wherein the cosmetic composition has a formulation selected from the group consisting of solutions, suspensions, emulsions, pastes, gels, creams and lotions.

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