KR20140059958A - Composition for obesity treatment and improvement which contains extract of flower petals of zingiber mioga - Google Patents
Composition for obesity treatment and improvement which contains extract of flower petals of zingiber mioga Download PDFInfo
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- A—HUMAN NECESSITIES
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61K36/9062—Alpinia, e.g. red ginger or galangal
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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- A61K2236/30—Extraction of the material
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Abstract
Description
본 발명은 양하 꽃잎의 추출물을 포함하는 비만 치료 및 개선용 조성물에 대한 것이다.The present invention relates to a composition for the treatment and improvement of obesity comprising an extract of Yangil petals.
비만은 섭취한 지방 또는 섭취한 열량 중에서 소모되고 남은 부분이 지방으로 전환되어 체내의 여러 부분, 특히 피하조직과 복강 내에 축적되는 현상이다. 최근 과도한 영양 섭취와 운동 부족으로 인하여, 비만 인구가 급격히 증가하게 되었으며, 이에 따라 비만을 개선, 치료하고자 하는 다양한 연구가 진행되고 있다. 예컨대, 한국공개특허 2012-0022764호에는 포유류의 위장관 내에서 서식할 수 있고 자유지방산 흡수능이 있는 유산균을 이용한 비만 치료제가 개시되어 있고, 또다른 한국공개특허2012-0016960호에는 다시마를 유효성분으로 함유하는 비만 치료용 조성물이 개시되어 있다.
Obesity is a phenomenon in which fat is consumed in the fat consumed or calories consumed and the remaining portion is converted to fat and accumulated in various parts of the body, especially in the subcutaneous tissue and the abdominal cavity. Recently, due to excessive nutrition and lack of exercise, the obesity population has rapidly increased, and accordingly various studies for improving and treating obesity are under way. For example, Korean Unexamined Patent Publication No. 2002-0022764 discloses an agent for treating obesity using lactic acid bacteria capable of living in the gastrointestinal tract of mammals and capable of absorbing free fatty acids. In another Korean Patent Publication No. 2012-0016960, kelp is contained as an active ingredient A composition for treating obesity is disclosed.
비만의 가장 큰 원인 중 하나는 과도한 지방의 섭취로, 섭취된 지방은 pancreatic liapse에 의하여 분해된 후 지방세포의 분화 과정(adipocyte differentiation)을 통하여 지방 세포내에 축적되게 된다. 그러므로 pancreatic lipase의 저해를 통하여 지방 흡수를 억제하고, 지방세포 분화를 저해함으로써 지방의 축적을 저해하는 것이 비만 치료제 개발의 중요한 방향이 된다.
One of the major causes of obesity is the excessive intake of fat, which is then degraded by pancreatic lysis and accumulated in adipocytes through adipocyte differentiation. Therefore, inhibiting fat absorption through inhibition of pancreatic lipase, inhibiting adipocyte differentiation, inhibiting accumulation of fat is an important direction of development of obesity treatment.
이에 본 발명자는 지방 흡수 저해능을 갖는 성분을 연구하던 중 양하(Zingiber moiga) 꽃잎 추출물이 pancreatic lipase 저해를 통하여 지방 흡수를 억제하는 것을 확인하고 본 발명을 완성하였다.
Accordingly, the present inventors have found that the Zingiber moiga petal extract inhibits lipid absorption through inhibition of pancreatic lipase, and completed the present invention.
본 발명의 목적은 비만 치료 및 개선용 조성물을 제공하는 것이다. It is an object of the present invention to provide a composition for treating and improving obesity.
상기 목적을 달성하기 위하여 본 발명은 양하 꽃잎의 추출물을 포함하는 비만 치료 및 개선용 조성물을 제공한다.In order to accomplish the above object, the present invention provides a composition for treating and improving obesity comprising an extract of Yangil petals.
본 발명의 양하 꽃잎의 추출물을 포함하는 조성물은 지방의 체내 흡수를 저해함으로써 비만을 치료, 예방 및 개선하는 효과가 있다. The composition of the present invention containing the extract of the alabaster petal has an effect of treating, preventing and improving obesity by inhibiting the absorption of fat in the body.
도 1은 양하 꽃잎 추출물의 pancreatic lipase 저해 활성을 나타낸다. 이는 대조군을 100으로 한 상대적 활성으로 나타낸 것이다.Fig. 1 shows the pancreatic lipase inhibitory activity of alfalfa extract. This represents the relative activity as 100 for the control.
본 발명은 양하 꽃잎의 추출물을 포함하는 비만 개선, 치료 및 예방용 조성물에 대한 것이다.
The present invention relates to a composition for improving, treating and preventing obesity comprising an extract of Yangil petals.
또한 본 발명은 양하 꽃잎의 추출물을 포함하는 비만 개선 및 예방용 식품 조성물에 대한 것이다.
The present invention also relates to a food composition for improving and preventing obesity, which comprises an extract of Yangil petals.
또한 본 발명은 또한 양하 꽃잎의 추출물을 포함하는 비만 치료 및 예방용 약학적 조성물에 대한 것이다.
The present invention also relates to a pharmaceutical composition for the treatment and prevention of obesity comprising an extract of Yangil petals.
또한 본 발명은 양하 꽃잎의 추출물을 포함하는 화장료 조성물에 대한 것이다.
The present invention also relates to a cosmetic composition comprising an extract of Yangil petals.
또한 본 발명은 양하 꽃잎의 추출물을 포함하는 사료 조성물에 대한 것이다.
The present invention also relates to a feed composition comprising an extract of Yangil petals.
또한 본 발명은 양하 꽃잎을 추출하는 단계를 포함하는 비만 개선, 치료 및 예방용 조성물의 제조 방법에 대한 것이다.
The present invention also relates to a method for preparing a composition for improving, treating and preventing obesity, which comprises extracting a reducing petal.
또한 본 발명은 양하 꽃잎을 추출하는 단계를 포함하는 비만 개선 및 예방용 식품 조성물의 제조 방법에 대한 것이다.
The present invention also relates to a method for preparing a food composition for improving and preventing obesity, which comprises extracting a lowered petal.
또한 본 발명은 양하 꽃잎을 추출하는 단계를 포함하는 비만 치료 및 예방용 약학적 조성물의 제조 방법에 대한 것이다.
The present invention also relates to a process for the preparation of a pharmaceutical composition for the treatment and prevention of obesity, which comprises extracting the lowered petals.
또한 본 발명은 양하 꽃잎을 추출하는 단계를 포함하는 화장료 조성물의 제조 방법을 제공한다.
The present invention also provides a method for producing a cosmetic composition comprising extracting a reducing petal.
또한 본 발명은 양하 꽃잎을 추출하는 단계를 포함하는 사료 조성물의 제조 방법을 제공한다.
The present invention also provides a method for preparing a feed composition comprising extracting a reducing petal.
이하, 본 발명을 자세히 설명한다.
Hereinafter, the present invention will be described in detail.
양하 꽃잎Petal
본 발명의 양하 꽃잎은 일반적인 양하 꽃잎이면 되고, 그 산지 등이 특별히 제한되는 것은 아니다. 본 발명의 양하 꽃잎은 건조된 것을 구입하여 이용할 수도 있으나, 생화를 이용할 수도 있다.
The saccharide petal of the present invention may be a general saccharide petal, and the origin thereof is not particularly limited. The dried petals of the present invention may be purchased and used, but the flowers may be used.
양하 꽃잎의 추출Extraction of Yangsan petals
본 발명의 양하 꽃잎 추출물은 물, 탄소 수 5 이하의 알코올 및 탄소 수 3 이하의 알킬 할라이드로 구성되는 군으로부터 선택되는 하나 이상의 용매로 양하 꽃잎를 추출하여 제조한다. 상기 알코올은 메탄올, 에탄올, 프로판올, 부탄올, 펜탄올, 1,3 프로판디올 등이 될 수 있고, 바람직하게는 메탄올이나, 이에 제한되는 것은 아니다. 상기 알킬 할라이드는 메틸 클로라이드, 에틸 클로라이드, 프로필 클로라이드, 메틸 브로마이드, 에틸 브로마이드, 프로필 브로마이드, 메틸렌 클로라이드, 디클로로에탄 등이 될 수 있고, 바람직하게는 메틸렌 클로라이드이나 이에 제한되는 것은 아니다. The safflower extract of the present invention is prepared by extracting alfalfa with at least one solvent selected from the group consisting of water, alcohols having 5 or less carbon atoms, and alkyl halides having 3 or less carbon atoms. The alcohol may be methanol, ethanol, propanol, butanol, pentanol, 1,3-propanediol, and the like, preferably methanol, but is not limited thereto. The alkyl halide may be methyl chloride, ethyl chloride, propyl chloride, methyl bromide, ethyl bromide, propyl bromide, methylene chloride, dichloroethane and the like, preferably methylene chloride.
바람직하게는 본 발명의 양하 꽃잎 추출물은 상기 탄소 수 5 이하의 알코올 및 탄소 수 3 이하의 알킬 할라이드의 혼합 용매를 이용하여 제조된다. 더욱 바람직하게는 본 발명의 양하 꽃잎 추출물은 상기 탄소 수 5 이하의 알코올 및 탄소 수 3 이하의 알킬 할라이드를 1 : 0.5 ~ 1.5 의 중량비로 혼합한 혼합 용매를 이용하여 제조되며, 더더욱 바람직하게는 상기 탄소 수 5 이하의 알코올 및 탄소 수 3 이하의 알킬 할라이드를 1:1의 중량비로 혼합한 혼합 용매를 이용하여 제조된다.
Preferably, the extract of Safflower oil of the present invention is prepared by using a mixed solvent of alcohol having 5 or less carbon atoms and alkyl halide having 3 or less carbon atoms. More preferably, the extract of alabaster petals of the present invention is prepared using a mixed solvent obtained by mixing the alcohol having 5 or less carbon atoms and the alkyl halide having 3 or less carbon atoms in a weight ratio of 1: 0.5 to 1.5, An alcohol having 5 or less carbon atoms and an alkyl halide having 3 or less carbon atoms in a weight ratio of 1: 1.
비만 치료, 개선 및 예방Obesity treatment, improvement and prevention
본 발명의 양하 꽃잎 추출물를 포함하는 조성물은 비만의 치료, 개선 및 예방능을 갖는다. 또한 본 발명의 조성물은 지방의 체내 흡수를 저해함으로서 비만을 치료, 개선 및 예방할 수 있다.
The composition comprising the extract of alfalfa extract of the present invention has the ability to treat, improve and prevent obesity. In addition, the composition of the present invention can treat, ameliorate and prevent obesity by inhibiting the absorption of fat in the body.
약학적 조성물Pharmaceutical composition
본 발명은 양하 꽃잎 추출물을 포함하는 비만의 치료 및 예방용 약학적 조성물에 대한 것이다. 본 발명의 약학적 조성물은 내장비만, 복부비만, 고지혈증, 지방간 및 비만으로 구성된 군으로부터 선택되는 질환을 예방 또는 치료한다. 또한 본 발명의 약학적 조성물은 그 외에도 혈중 지질 농도 증가, 중성지방 축적 등과 관련된 질환에 복합적인 효과를 갖는다.
The present invention relates to a pharmaceutical composition for the treatment and prevention of obesity, which comprises extracts of alfalfa extract. The pharmaceutical compositions of the present invention prevent or treat diseases selected from the group consisting of visceral obesity, abdominal obesity, hyperlipidemia, fatty liver and obesity. In addition, the pharmaceutical composition of the present invention has a complex effect on diseases related to an increase in blood lipid concentration, accumulation of triglycerides, and the like.
본 발명의 약학적 조성물은 상기 양하 꽃잎 추출물을 0.01 내지 80 중량% 포함할 수 있으며, 바람직하게는 0.02 내지 65 중량% 포함할 수 있다. 그러나 이는 투약자의 필요에 따라 증감할 수 있으며, 식생활, 영양 상태, 병의 진행 정도, 비만의 정도 등 상황에 따라 적절히 증감할 수 있다.
The pharmaceutical composition of the present invention may contain 0.01 to 80% by weight, preferably 0.02 to 65% by weight, of the alabaster extract. However, this can be increased or decreased according to the needs of the medicinal person, and can be appropriately increased or decreased according to the situation such as the diet, nutritional status, disease progression, degree of obesity and the like.
본 발명의 약학적 조성물은 경구 또는 비경구로 투여가 가능하며 일반적인 의약품 제제의 형태로 사용될 수 있다. 바람직한 약제학적 제제는 정제, 경질 또는 연질 캅셀제, 액제, 현탁제 등과 같은 경구투여용 제제가 있으며 이들 약제학적 제제는 약제학적으로 허용 가능한 통상의 담체, 예를 들어 경구투여용 제제의 경우에는 부형제, 결합제, 붕해제, 활택제, 가용화제, 현탁화제, 보존제 또는 증량제 등을 사용하여 조제할 수 있다.
The pharmaceutical composition of the present invention can be administered orally or parenterally and can be used in the form of a general pharmaceutical preparation. The preferred pharmaceutical preparations are those for oral administration such as tablets, hard or soft capsules, liquids, suspensions, etc. These pharmaceutical preparations can be prepared in conventional pharmaceutically acceptable carriers, for example, as excipients for oral preparations, Binders, disintegrators, lubricants, solubilizers, suspending agents, preservatives or extenders.
본 발명의 양하 꽃잎 추출물을 포함하는 약학적 조성물의 투여 용량은, 환자의 상태, 연령, 성별 및 합병증 등의 다양한 요인에 따라 전문가에 의해 결정될 수 있지만 일반적으로는 성인 1kg 당 0.1㎎ 내지 10g, 바람직하게는 10 mg 내지 5g의 용량으로 투여될 수 있다. 또, 단위 제형당 상기 약학적 조성물의 1일 용량 또는 이의 1/2, 1/3 또는 1/4의 용량이 함유되도록 하며, 하루 1 내지 6 회 투여될 수 있다. 그러나 건강 및 위생을 목적으로 하거나 또는 건강 조절을 목적으로 하는 장기간의 섭취의 경우에는 상기 양은 상기 범위 이하일 수 있으며, 유효성분은 안전성 면에서 아무런 문제가 없기 때문에 상기 범위 이상의 양으로도 사용될 수 있다.
The dose of the pharmaceutical composition containing the extract of alfalfa extract of the present invention may be determined by an expert according to various factors such as the condition of the patient, age, sex, and complications, but is generally from 0.1 mg to 10 g per kg of the adult, Lt; RTI ID = 0.0 > mg < / RTI > to 5 g. Also, the daily dosage of the pharmaceutical composition per unit dosage form, or a half, 1/3 or 1/4 dose thereof, may be contained, and may be administered 1 to 6 times per day. However, in the case of long-term intake for the purpose of health and hygiene or for the purpose of controlling health, the amount may be less than the above range, and the active ingredient may be used in an amount of more than the above range since there is no problem in terms of safety.
식품 조성물Food composition
본 발명의 식품은 건강보조식품, 건강기능식품, 기능성 식품 등이 될 수 있으나 이에 제한되는 것은 아니며, 천연식품, 가공식품, 일반적인 식자재 등에 본 발명의 양하 꽃잎 추출물을 첨가하는 것도 포함된다.
The food of the present invention may be a health supplement food, a health functional food, a functional food, and the like, but is not limited thereto and includes the addition of the extracts of the present invention to natural foods, processed foods, and general food ingredients.
본 발명의 식품 조성물은, 상기 양하 꽃잎 추출물을 그대로 첨가하거나 다른 식품 또는 식품 조성물과 함께 사용될 수 있으며, 통상적인 방법에 따라 적절하게 사용될 수 있다. 유효 성분의 혼합양은 그의 사용 목적(예방, 개선 또는 치료적 처치)에 따라 적합하게 결정될 수 있다. 일반적으로, 본 발명의 양하 꽃잎 추출물은, 식품 또는 음료의 제조 시에 식품 또는 음료의 원료 100 중량%에 대하여 0.1 내지 70 중량%, 바람직하게는 2 내지 50 중량%로 첨가될 수 있다. 상기 양하 꽃잎 추출물의 유효용량은 상기 약학적 조성물의 유효용량에 준해서 사용할 수 있으나, 건강 및 위생을 목적으로 하거나 또는 건강 조절을 목적으로 하는 장기간의 섭취의 경우에는 상기 범위 이하일 수 있으며, 유효성분은 안전성 면에서 아무런 문제가 없기 때문에 상기 범위 이상의 양으로도 사용될 수 있다.
The food composition of the present invention can be used as it is or in combination with other food or food compositions, and can be suitably used according to conventional methods. The amount of the active ingredient to be mixed can be suitably determined according to its intended use (prevention, improvement, or therapeutic treatment). In general, the extract of alfalfa extract of the present invention may be added in an amount of 0.1 to 70% by weight, preferably 2 to 50% by weight, based on 100% by weight of the raw material of the food or beverage when the food or beverage is prepared. The effective dose of the alfalfa extract may be used in accordance with the effective dose of the pharmaceutical composition, but may be less than the above range for the purpose of health and hygiene or long-term intake for the purpose of health control, Can be used in an amount exceeding the above range since there is no problem in terms of safety.
상기 식품의 종류에는 특별한 제한은 없다. 상기 식품 조성물은 정제, 경질 또는 연질 캅셀제, 액제, 현탁제 등과 같은 경구투여용 제제의 형태로 이용될 수 있으며, 이들 제제는 허용 가능한 통상의 담체, 예를 들어 경구투여용 제제의 경우에는 부형제, 결합제, 붕해제, 활택제, 가용화제, 현탁화제, 보존제 또는 증량제 등을 사용하여 조제할 수 있다.
There is no particular limitation on the kind of the food. The food composition may be used in the form of tablets, hard or soft capsules, liquids, suspensions, and the like, which may contain conventional excipients, such as excipients in the case of oral preparations, Binders, disintegrators, lubricants, solubilizers, suspending agents, preservatives or extenders.
상기 양하 꽃잎 추출물을 첨가할 수 있는 식품의 예로는 육류, 소세지, 빵, 쵸코렛, 캔디류, 스넥류, 과자류, 피자, 라면, 기타 면류, 껌류, 아이스크림류를 포함한 낙농제품, 각종 스프, 음료수, 차, 드링크제, 알콜 음료 및 비타민 복합제, 기타 영양제 등을 들 수 있으나 이들 종류의 식품으로 제한되는 것은 아니다.
Examples of the food to which the alfalfa extract can be added include dairy products such as meat, sausage, bread, chocolate, candy, snack, confectionery, pizza, ramen, other noodles, gums, ice cream, Drinks, alcoholic beverages and vitamin complexes, and other nutrients, but the present invention is not limited to these kinds of foods.
화장료 조성물Cosmetic composition
본 발명은 양하 꽃잎 추출물을 포함하는 화장료 조성물에 대한 것이다.The present invention relates to a cosmetic composition comprising an extract of alfalfa extract.
본 발명의 화장료 조성물은 셀룰라이트 개선 효과가 있다. 상기 셀룰라이트 개선 효과란 셀룰라이트의 부피가 작아지는 것, 셀루라이트의 높이가 낮아지는 것, 셀룰라이트가 제거되는 것, 셀룰라이트 및 그 주위가 편평하여지는 것 등을 가리킨다.
The cosmetic composition of the present invention has cellulite improving effect. The cellulite improvement effect refers to a decrease in the volume of the cellulite, a decrease in the height of the cellulite, a removal of cellulite, and a flattening of the cellulite and its surroundings.
본 발명의 화장료 조성물은 피부가 매끈하여지는 효과가 있다. 이는 피하의 지방세포 및 그 주위의 노폐물, 수분 등이 뭉쳐 피부가 울퉁불퉁하여지는 것을 저해, 방지하는데 따른 효과이며, 이로써 셀룰라이트가 생기는 것을 예방할 수도 있다.
The cosmetic composition of the present invention has an effect of smooth skin. This is an effect of inhibiting and preventing the skin from becoming uneven due to aggregation of subcutaneous adipocytes and surrounding waste water and moisture, thereby preventing cellulite from being formed.
한편 본 발명의 화장료 조성물은 바디 슬리밍 효과가 있다. 바디 슬리밍이란 지방이 피하에 고르게 분포하지 않아 울퉁불퉁하게 보이는 바디 라인에 있어, 지방이 고르게 재분포되도록 촉진하는 것, 신체 또는 신체의 일부분의 부피를 감소시키는 것, 붓기를 제거하여 결과적으로 신체 또는 신체의 일부분의 부피를 감소시키는 것, 국소비만 상태의 개선, 지방 세포 내의 지방을 분해하여 배출시켜 주는 것, 지방 세포 내의 트리글리세라이드 및 체액 축적을 감소시키는 것 등을 의미한다.
Meanwhile, the cosmetic composition of the present invention has a body slimming effect. Body slimming refers to promoting the redistribution of fat evenly in the bumpy body line that is not uniformly distributed under the skin, reducing the volume of the body or part of the body, Reducing the volume of a portion of the fat cells, improving localized obesity, dissolving fat in adipocytes, reducing triglycerides and body fluid accumulation in adipocytes, and the like.
본 발명의 화장료 조성물은 남성용 화장료 또는 여성용 화장료 모두에 적용될 수 있다. 그러나 셀룰라이트가 여성에게 잘 생기는 점을 감안할 때 본 발명의 화장료 조성물은 여성용 화장료 조성물로 이용하는 것이 유용하다. 또한 임신부의 호르몬 변화로 인한 셀룰라이트 발생을 예방하기 위하여, 본 발명의 화장료 조성물을 이용할 수도 있다.
The cosmetic composition of the present invention can be applied to both men's cosmetics and women's cosmetics. However, considering that cellulite is well-tolerated by women, it is useful to use the cosmetic composition of the present invention as a cosmetic composition for women. The cosmetic composition of the present invention may also be used to prevent the development of cellulite due to hormonal changes in the pregnant woman.
본 발명의 화장료 조성물은, 당업계의 통상적으로 제조되는 어떠한 제형에도 제조될 수 있으며 용액, 현탁액, 유탁액, 페이스트, 젤, 크림, 로션, 파우더, 비누, 계면활성제-함유 클렌징, 오일, 분말 파운데이션, 유탁액 파운데이션, 왁스 파운데이션 및 스프레이 등으로 제형화될 수 있으나, 이에 제한되는 것은 아니다. 또한 본 발명의 화장료 조성물은 유연화장수, 영양화장수, 영양크림, 마사지크림, 에센스, 아이크림, 클렌징크림, 클렌징폼, 클렌징워터, 팩, 스프레이 또는 파우더 제형으로 제조될 수도 있다.
The cosmetic composition of the present invention may be prepared in any formulations conventionally produced in the art and may be formulated into a solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant- containing cleansing oil, powder foundation , An emulsion foundation, a wax foundation and a spray, but is not limited thereto. The cosmetic composition of the present invention may also be formulated as a softening agent, a nutritional lotion, a nutritional cream, a massage cream, an essence, an eye cream, a cleansing cream, a cleansing foam, a cleansing water, a pack, a spray or a powder.
본 발명의 화장료 조성물은 효과적인 경피 흡수를 위하여 피부 침투 촉진제를 포함할 수 있다. 상기 피부 침투 촉진제는 당 업계에서 화장료 조성물에 사용하는 일반적인 피부 침투 촉진제면 되고, 특별히 제한되는 것은 아니다. 예컨대 본 발명의 피부 침투 촉진제는 디메틸 설폭사이드, oleic acid 등 지방산/에스테르 화합물, 리모넨(limonene) 등이 될 수 있다.
The cosmetic composition of the present invention may contain a skin penetration promoter for effective transdermal absorption. The skin penetration promoting agent is not particularly limited so long as it is a general skin penetration promoting agent used in the cosmetic composition in the art. For example, the skin penetration promoter of the present invention may be a fatty acid / ester compound such as dimethylsulfoxide, oleic acid, limonene, and the like.
또한 본 발명의 화장료 조성물을 이용 시에는 충격파, 이온삼투요법, 전기침공법, 미세침요법 등 물리적 방법을 병용하여 경피 흡수를 촉진할 수도 있다.
When the cosmetic composition of the present invention is used, transdermal absorption may be promoted by using physical methods such as shock waves, iontophoresis, electrical invasion, and microinfiltration.
사료 조성물Feed composition
본 발명은 양하 꽃잎 추출물을 포함하는 사료 조성물에 대한 것이다. 본 발명의 사료 조성물은 통상적인 사료와 함께 배식할 수 있으며, 본 발명의 사료 조성물을 통상적인 사료 조성물에 첨가하여 기능성 사료 조성물을 제조하여 이용할 수도 있다. 또한 본 발명의 사료 조성물은 본 발명의 양하 꽃잎 추출물 외 기능성 성분을 추가로 포함할 수도 있다. 상기 통상적인 사료 조성물과 본 발명의 양하 꽃잎 추출물이 혼합된 기능성 사료 조성물의 제조 시, 본 발명의 양하 꽃잎 추출물은 총 사료 조성물에 대하여 0.01 내지 30.00 중량%, 바람직하게는 0.01 내지 20.00 중량%의 양으로 첨가될 수 있다. 사료 조성물의 상기 양하 꽃잎 추출물의 유효용량은 상기 식품 조성물의 유효 용량에 준해서 사용할 수 있으나, 지속적인 체중 관리를 목적으로 하거나 또는 건강 조절을 목적으로 하는 장기간의 섭취의 경우에는 상기 범위 이하일 수 있으며, 유효성분은 안전성 면에서 아무런 문제가 없기 때문에 고도 비만 등의 경우에는 상기 범위 이상의 양으로도 사용될 수 있다.
The present invention is directed to a feed composition comprising an extract of alfalfa. The feed composition of the present invention can be seeded with conventional feeds, and the feed composition of the present invention can be added to a conventional feed composition to prepare a functional feed composition. In addition, the feed composition of the present invention may further comprise a functional ingredient other than the alabaster extract of the present invention. When preparing the functional feed composition containing the conventional feed composition and the petals of the present invention, the extract of the petals of the present invention is added in an amount of 0.01 to 30.00% by weight, preferably 0.01 to 20.00% by weight based on the total feed composition . The effective dose of the Petal Leaf Extract of the feed composition may be used according to the effective dose of the food composition but may be less than the above range for the purpose of continuous weight management or for long- Since the active ingredient has no problem in terms of safety, it can be used in an amount exceeding the above range in the case of high obesity.
본 발명의 사료 조성물은 가축 또는 가금을 대상으로 한다. 상기 가축 또는 가금은 소, 돼지, 닭, 말, 양, 당나귀, 노새, 멧돼지, 토끼, 메추라기, 집오리, 장닭, 투계용 닭, 비둘기, 칠면조, 개, 고양이, 원숭이, 햄스터, 생쥐, 래트, 구관조, 앵무새, 잉꼬, 카나리아 등이나 이들에 제한되는 것은 아니며 가정 내에서 사육 가능한 인간 이외의 포유 동물 또는 조류이면 본 발명의 사료 조성물의 대상이라 할 것이다.
The feed composition of the present invention is intended for livestock or poultry. The livestock or poultry may be any kind of animal such as cattle, pigs, chickens, horses, sheep, donkeys, mules, boars, rabbits, quail, ducks, fowls, poultry chickens, pigeons, turkeys, dogs, cats, monkeys, hamsters, , Parrots, parakeets, canaries, and the like, but are not limited to mammals or birds other than humans capable of breeding in the home.
본 발명의 이점 및 특징, 그리고 그것들을 달성하는 방법은 첨부되는 도면과 함께 상세하게 후술되어 있는 실시예들을 참조하면 명확해질 것이다. 그러나, 본 발명은 이하에서 개시되는 실시예들에 한정되는 것이 아니라 서로 다른 다양한 형태로 구현될 것이며, 단지 본 실시예들은 본 발명의 개시가 완전하도록 하며, 본 발명이 속하는 기술분야에서 통상의 지식을 가진 자에게 발명의 범주를 완전하게 알려주기 위해 제공되는 것이며, 본 발명은 청구항의 범주에 의해 정의될 뿐이다.
BRIEF DESCRIPTION OF THE DRAWINGS The advantages and features of the present invention, and the manner of achieving them, will be apparent from and elucidated with reference to the embodiments described hereinafter in conjunction with the accompanying drawings. It should be understood, however, that the invention is not limited to the disclosed embodiments, but is capable of many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, To fully disclose the scope of the invention to those skilled in the art, and the invention is only defined by the scope of the claims.
재료material
시중에서 판매하는 건조된 양하 꽃잎을 구입하여 사용하였다.
Dried zanthoxylum, commercially available, was purchased and used.
양하 꽃잎 추출물의 제조 Manufacture of extract
건조된 양하 꽃잎을 분쇄기를 이용하여 분쇄하였다. 상기 양하 꽃잎 분말 20g을 고속 추출기용 100 ml cell에 넣고, 메틸렌 클로라이드와 메탄올을 1:1의 중량비로 혼합한 혼합물을 추출용매로 하여 추출하였다. 상기 추출은 80 ℃에서 40분간 고속추출기를 이용하여 수행되었으며, 이렇게 얻어진 추출물을 감압 농축하였다. 감압 농축으로 수득된 최종 추출물은 1.65g이었다.
The dried petals were crushed using a pulverizer. 20 g of the petal powder was placed in a 100 ml cell for high speed extractor, and a mixture of methylene chloride and methanol at a weight ratio of 1: 1 was extracted as an extraction solvent. The extraction was carried out at 80 ° C for 40 minutes using a high-speed extractor, and the thus-obtained extract was concentrated under reduced pressure. The final extract obtained by concentration under reduced pressure was 1.65 g.
<실험예 1> pancreatic lipase 저해 활성<Experimental Example 1> Pancreatic lipase inhibitory activity
상기 수득한 농축된 양하 꽃잎 추출물을 시료로 이용하여, lipase에서 가장 큰 부분을 차지하는 pancreatic lipase에 대한 저해 활성을 시험하였다. 먼저, Porcine pancreatlic lipase를 0.1 M tris-HCl buffer에 100 μg/ml의 농도로 준비한 후 시료와 함께 10분간 방치하였다. 그리고 기질인 4-nitrophenyl butyrate (4-NPB)를 최종농도 0.5 mM이 되도록 가하여 반응을 시작하였다. 상온에서 15분간 방치하여 반응을 진행하였으며 생성된 p-nitrophenol의 양을 405nm에서 흡광도를 측정하여 반응의 저해를 정량적으로 판단하였다. 이 때, 기질인 4-NPB는 첨가하고, 시료를 첨가하지 않는 반응액을 대조군으로 하여 시료의 pancreatic lipase의 저해정도를 판단하였다.
Using the thus obtained concentrated extract of Solanum petioles as a sample, the inhibitory activity against pancreatic lipase, which occupies the largest portion in lipase, was tested. First, Porcine pancreatic lipase was prepared at a concentration of 100 μg / ml in 0.1 M tris-HCl buffer and left for 10 minutes with the sample. The reaction was started by adding 4-nitrophenyl butyrate (4-NPB) as a substrate to a final concentration of 0.5 mM. The reaction was allowed to proceed for 15 minutes at room temperature. The amount of p-nitrophenol produced was quantitatively determined by measuring the absorbance at 405 nm. At this time, 4-NPB as a substrate was added, and the inhibition of the pancreatic lipase of the sample was determined using a reaction solution to which no sample was added as a control.
그 결과, 양하 꽃잎 추출물은 pancreatic lipase의 저해 활성을 갖는 것으로 확인되었다(도 1).
As a result, it was confirmed that the alfalfa extract had an inhibitory activity of pancreatic lipase (Fig. 1).
Claims (12)
A food composition for the improvement and prevention of obesity comprising extracts of Yangsus petals.
상기 추출물은 탄소 수 5 이하의 알코올 및 탄소 수 3 이하의 알킬 할라이드로 구성되는 군으로부터 선택되는 하나 이상의 용매로 양하 꽃잎을 추출하여 제조하는 것을 특징으로 하는 식품 조성물.
The method according to claim 1,
Wherein the extract is prepared by extracting alfalfa with at least one solvent selected from the group consisting of alcohols having 5 or less carbon atoms and alkyl halides having 3 or less carbon atoms.
상기 추출물은 메탄올 또는 메틸렌 클로라이드를 이용하여 추출하여 제조하는 것을 특징으로 하는 식품 조성물.
The method according to claim 1,
Wherein the extract is prepared by extracting with methanol or methylene chloride.
지방의 체내 흡수를 저해하는 것을 특징으로 하는 식품 조성물.
The method according to claim 1,
Thereby inhibiting the absorption of fat in the body.
A method for preparing a food composition for improving and preventing obesity comprising the steps of:
A pharmaceutical composition for the treatment and prevention of obesity, which comprises an extract of Yangsu petal.
상기 추출물은 탄소 수 5 이하의 알코올 및 탄소 수 3 이하의 알킬 할라이드로 구성되는 군으로부터 선택되는 하나 이상의 용매로 양하 꽃잎을 추출하여 제조하는 것을 특징으로 하는 약학적 조성물.
The method according to claim 1,
Wherein the extract is prepared by extracting the alfalfa leaf with at least one solvent selected from the group consisting of an alcohol having 5 or less carbon atoms and an alkyl halide having 3 or less carbon atoms.
상기 추출물은 메탄올 또는 메틸렌 클로라이드를 이용하여 추출하여 제조하는 것을 특징으로 하는 약학적 조성물.
The method according to claim 1,
Wherein the extract is prepared by extracting with methanol or methylene chloride.
지방의 체내 흡수를 저해하는 것을 특징으로 하는 약학적 조성물.
The method according to claim 1,
And inhibits absorption of fat in the body.
A method for preparing a pharmaceutical composition for the treatment and prevention of obesity, comprising the step of extracting a reducing petal.
A cosmetic composition comprising an extract of Yangsha petal.
A feed composition comprising an extract of Yangshan petals.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020120126455A KR20140059958A (en) | 2012-11-09 | 2012-11-09 | Composition for obesity treatment and improvement which contains extract of flower petals of zingiber mioga |
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| Application Number | Priority Date | Filing Date | Title |
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| KR1020120126455A KR20140059958A (en) | 2012-11-09 | 2012-11-09 | Composition for obesity treatment and improvement which contains extract of flower petals of zingiber mioga |
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| KR20140059958A true KR20140059958A (en) | 2014-05-19 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015115687A1 (en) * | 2014-01-29 | 2015-08-06 | 주식회사 유니베라 | Composition for treating and alleviating obesity, containing zingiber moiga leaf extract |
| KR20160044827A (en) * | 2014-10-16 | 2016-04-26 | 한국식품연구원 | Compositon for inhibiting quorum sensing comprising Zingiber mioga extract as effective component |
| KR102095031B1 (en) * | 2018-11-07 | 2020-03-31 | 주식회사 프롬바이오 | Composition for moisturing, anti-wrinkle or whitening with the extract of Zingiber mioga |
-
2012
- 2012-11-09 KR KR1020120126455A patent/KR20140059958A/en not_active Application Discontinuation
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015115687A1 (en) * | 2014-01-29 | 2015-08-06 | 주식회사 유니베라 | Composition for treating and alleviating obesity, containing zingiber moiga leaf extract |
| KR20160044827A (en) * | 2014-10-16 | 2016-04-26 | 한국식품연구원 | Compositon for inhibiting quorum sensing comprising Zingiber mioga extract as effective component |
| KR102095031B1 (en) * | 2018-11-07 | 2020-03-31 | 주식회사 프롬바이오 | Composition for moisturing, anti-wrinkle or whitening with the extract of Zingiber mioga |
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