KR20140038358A - 신규의 Wnt 조성물 및 이러한 조성물의 치료학적 용도 - Google Patents
신규의 Wnt 조성물 및 이러한 조성물의 치료학적 용도 Download PDFInfo
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- KR20140038358A KR20140038358A KR1020137020279A KR20137020279A KR20140038358A KR 20140038358 A KR20140038358 A KR 20140038358A KR 1020137020279 A KR1020137020279 A KR 1020137020279A KR 20137020279 A KR20137020279 A KR 20137020279A KR 20140038358 A KR20140038358 A KR 20140038358A
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| AU2012308476B2 (en) * | 2011-09-16 | 2016-04-14 | Fate Therapeutics, Inc. | Wnt compositions and therapeutic uses of such compositions |
| ES2690305T3 (es) | 2011-09-16 | 2018-11-20 | Ottawa Hospital Research Institute | Composiciones de Wnt7a y métodos de utilización de las mismas |
| CN111193048A (zh) | 2012-04-02 | 2020-05-22 | 水吉能公司 | 燃料电池模块及其启动、关闭和重新启动的方法 |
| WO2013188851A1 (en) * | 2012-06-14 | 2013-12-19 | Fred Hutchinson Cancer Research Center | Ex vivo expansion of myogenic stem cells by notch activation |
| WO2015051122A2 (en) * | 2013-10-02 | 2015-04-09 | The Board Of Trustees Of The Leland Stanford Junior University | Wnt compositions and methods for purification |
| WO2015148923A1 (en) * | 2014-03-28 | 2015-10-01 | Ottawa Hospital Research Institute | Wnt induced motility and enhanced engraftment of cells |
| AU2016270373A1 (en) | 2015-06-05 | 2018-01-04 | Vertex Pharmaceuticals Incorporated | Triazoles for the treatment of demyelinating diseases |
| WO2018106641A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Pyrazoles for the treatment of demyelinating diseases |
| WO2018106646A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Aminotriazoles for the treatment of demyelinating diseases |
| WO2018106643A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Heterocyclic azoles for the treatment of demyelinating diseases |
| CN108411003A (zh) * | 2018-05-22 | 2018-08-17 | 华中农业大学 | Wnt2基因片段作为影响猪红细胞数目性状的分子标记 |
| CN114933657B (zh) * | 2021-08-25 | 2024-02-02 | 上海交通大学医学院 | 神经生长因子突变体重组蛋白及其应用 |
| CN119019529B (zh) * | 2024-09-23 | 2026-04-10 | 华中农业大学 | Wnt5a基因或其编码蛋白在调控宿主抗bpiv-3中的应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4751180A (en) | 1985-03-28 | 1988-06-14 | Chiron Corporation | Expression using fused genes providing for protein product |
| US4935233A (en) | 1985-12-02 | 1990-06-19 | G. D. Searle And Company | Covalently linked polypeptide cell modulators |
| US5725871A (en) | 1989-08-18 | 1998-03-10 | Danbiosyst Uk Limited | Drug delivery compositions comprising lysophosphoglycerolipid |
| US5707644A (en) | 1989-11-04 | 1998-01-13 | Danbiosyst Uk Limited | Small particle compositions for intranasal drug delivery |
| JP3257675B2 (ja) | 1990-10-12 | 2002-02-18 | マックス−プランク−ゲゼルシャフト ツール フェルデルング デル ビッセンシャフテン エー.ファウ. | 修飾リボザイム |
| US5399363A (en) | 1991-01-25 | 1995-03-21 | Eastman Kodak Company | Surface modified anticancer nanoparticles |
| US5756353A (en) | 1991-12-17 | 1998-05-26 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol-and liposome-based delivery |
| US5652094A (en) | 1992-01-31 | 1997-07-29 | University Of Montreal | Nucleozymes |
| ES2105262T3 (es) | 1992-05-18 | 1997-10-16 | Minnesota Mining & Mfg | Dispositivo de suministro de farmaco a traves de las mucosas. |
| US5543158A (en) | 1993-07-23 | 1996-08-06 | Massachusetts Institute Of Technology | Biodegradable injectable nanoparticles |
| IE80468B1 (en) | 1995-04-04 | 1998-07-29 | Elan Corp Plc | Controlled release biodegradable nanoparticles containing insulin |
| US6001311A (en) | 1997-02-05 | 1999-12-14 | Protogene Laboratories, Inc. | Apparatus for diverse chemical synthesis using two-dimensional array |
| AU3751299A (en) | 1998-04-20 | 1999-11-08 | Ribozyme Pharmaceuticals, Inc. | Nucleic acid molecules with novel chemical compositions capable of modulating gene expression |
| US8637506B2 (en) * | 2003-09-22 | 2014-01-28 | Enzo Biochem, Inc. | Compositions and methods for bone formation and remodeling |
| EP2090649A1 (en) * | 2008-02-13 | 2009-08-19 | Fondazione Telethon | Method for reprogramming differentiated cells |
| JP5802195B2 (ja) * | 2009-04-27 | 2015-10-28 | オタワ ホスピタル リサーチ インスティチュート | 幹細胞を調節するための組成物および方法ならびにその使用 |
| AU2012308476B2 (en) * | 2011-09-16 | 2016-04-14 | Fate Therapeutics, Inc. | Wnt compositions and therapeutic uses of such compositions |
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- 2012-01-11 BR BR112013017711A patent/BR112013017711A2/pt not_active IP Right Cessation
- 2012-01-11 US US13/979,368 patent/US9403885B2/en active Active
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- 2012-01-11 EP EP12734079.2A patent/EP2663576B1/en active Active
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- 2012-01-11 KR KR1020137020279A patent/KR20140038358A/ko not_active Withdrawn
- 2012-01-11 CN CN2012800096501A patent/CN103476791A/zh active Pending
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023229445A1 (ko) * | 2022-05-27 | 2023-11-30 | 주식회사 진큐어 | 신규 펩타이드 및 그의 용도 |
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|---|---|
| CA2824235A1 (en) | 2012-07-19 |
| EP2663576A2 (en) | 2013-11-20 |
| EP2663576B1 (en) | 2017-11-01 |
| CN103476791A (zh) | 2013-12-25 |
| SG191933A1 (en) | 2013-08-30 |
| WO2012097093A2 (en) | 2012-07-19 |
| EP2663576A4 (en) | 2015-05-06 |
| BR112013017711A2 (pt) | 2016-08-23 |
| US20140142046A1 (en) | 2014-05-22 |
| JP5972283B2 (ja) | 2016-08-17 |
| US9403885B2 (en) | 2016-08-02 |
| AU2012205583B2 (en) | 2016-01-21 |
| AU2012205583A1 (en) | 2013-04-11 |
| WO2012097093A3 (en) | 2012-09-27 |
| JP2014507938A (ja) | 2014-04-03 |
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