KR20140029942A - Kit for analyzing specimen - Google Patents

Abstract

A kit for analyzing a specimen according to one embodiment of the present invention shows specimen reaction results due to a reaction with at least two reaction pads. The reaction pads has a water leak prevention gap therebetween to prevent water leak from the specimen. The water leak prevention gap can be formed in 0.5 mm or more.

Description

Kit for analyzing specimen < RTI ID = 0.0 >

The present invention relates to a sample analysis kit of the present invention, and more particularly to a sample analysis kit for analyzing multi-characteristics by single sample injection.

Recently, with increasing interest in health, various techniques for analyzing the health of the body using biological samples have been introduced.

In particular, the diagnostic kit can be used to easily check health by analyzing trace biological samples.

In order to analyze the final results of these diagnostic kits, an antigen-antibody reaction or an enzyme reaction generated by a biological sample should be displayed in a diagnostic kit. You will know.

On the other hand, the above-described diagnostic kit has a charging hole for injecting a biological sample, and one characteristic can be analyzed by one diagnostic kit.

However, since biological samples such as blood contain a large amount of information, using separate diagnostic kits for analyzing a large amount of information from the blood is problematic in terms of cost and efficiency.

Therefore, in order to analyze the health condition of the body by using the diagnostic kit, it is urgently necessary to research to maximize the efficiency at a low cost.

An object of the present invention is to provide a kit for analyzing a specimen which realizes low cost and high efficiency by accurately analyzing multi-characteristics of a specimen by injecting a single specimen.

The kit for analyzing a specimen according to an embodiment of the present invention is a kit for analyzing a specimen which is immersed in at least two or more reaction pads and exhibits a specimen reaction result by each of the reaction pads, The leakage preventing gap may be formed to have a gap of at least 0.5 mm between the other reaction pads.

The sample analyzing kit according to an embodiment of the present invention is characterized in that when the total volume of a sample injected into at least two reaction pads is within an error range of ± 20 μl based on 240 μl, And may have an error range of ± 2.0 mm based on 4.0 mm.

The leakage preventing gap of the sample analyzing kit according to an embodiment of the present invention may be formed to be 0.7 mm or more.

In a sample analyzing kit according to an embodiment of the present invention, when the total volume of a specimen injected into at least two reaction pads is in a range of 220 ㎕ to 240 이하, the width of at least two reaction pads is 3.8 mm or more 3.9 mm or less.

In the specimen analyzing kit according to an embodiment of the present invention, when the total volume of specimens injected into at least two reaction pads is in the range of 220 ㎕ to 250,, the width of at least two reaction pads is 4.0 mm or more It may be within a range of 4.2 mm or less.

In a sample analyzing kit according to an embodiment of the present invention, when the total volume of specimens injected into at least two reaction pads is 260 mu L, the width of at least two reaction pads is within a range of 4.0 mm to 4.2 mm And the leakage preventing gap may be formed to be 0.6 mm or more.

A kit for analyzing a specimen according to an embodiment of the present invention includes a case having an injection unit for injecting the specimen and allowing the specimen to penetrate into at least two reaction pads and a display unit for exposing the specimen reaction result to the outside .

The injection unit of the kit for analyzing a specimen according to an embodiment of the present invention may be formed so as to communicate with the outside so as to correspond to each reaction pad.

The case of the kit for analyzing a specimen according to an embodiment of the present invention may have a fixing wall for fixing at least two or more reaction pads inside the case while maintaining the leakage preventing gap.

The fixing wall of the kit for analyzing a specimen according to an embodiment of the present invention may be formed in the periphery of the injecting part and formed to be offset from the injecting part.

According to the kit for analyzing a specimen according to the present invention, it is possible to simultaneously analyze the multi-characteristics of a specimen by inputting a single specimen.

In addition, it is possible to prevent leakage and interference of the sample during the simultaneous analysis of the multi-characteristic of the sample, thereby obtaining a more accurate analysis result.

Further, low cost and high efficiency can be realized.

1 is a schematic perspective view showing a sample analyzing kit according to an embodiment of the present invention.
FIG. 2 is a schematic exploded perspective view showing a sample analyzing kit according to an embodiment of the present invention. FIG.
3 is a schematic plan view showing a receiving unit provided in a sample analyzing kit according to an embodiment of the present invention;
4 is a schematic perspective view showing a sample analyzing kit according to another embodiment of the present invention.
5 is a schematic exploded perspective view showing a sample analyzing kit according to another embodiment of the present invention.
6 is a schematic plan view showing a receiving unit provided in a sample analyzing kit according to an embodiment of the present invention;

Hereinafter, with reference to the drawings will be described in detail a specific embodiment of the present invention. It will be apparent to those skilled in the art that various modifications and variations can be made in the present invention without departing from the spirit or scope of the inventive concept. Other embodiments falling within the scope of the inventive concept may readily be suggested, but are also considered to be within the scope of the present invention.

The same reference numerals are used to designate the same components in the same reference numerals in the drawings of the embodiments.

2 is a schematic exploded perspective view illustrating a kit for analyzing a specimen according to an embodiment of the present invention. FIG. 3 is a cross-sectional view of a kit for analyzing a specimen according to an embodiment of the present invention FIG. 3 is a schematic plan view showing a receiving unit provided in a sample analyzing kit according to an embodiment of the present invention.

1 to 3, a sample analyzing kit 10 according to the present invention includes a case 100 for providing a predetermined internal space S and at least two reaction pads (not shown) disposed in the internal space S, (130).

Specifically, the case 100 may include a cover unit 110 and a receiving unit 120 that is coupled to the cover unit 110 to form a predetermined internal space S, S, two or more reaction pads 130 may be disposed so as to simultaneously analyze the multi-characteristics of the specimen by injecting a single sample.

An injection unit 112 communicating with the reaction pad 130 is provided in the case 100, that is, the cover unit 110, so that the specimen can permeate the reaction pads 130 .

In other words, the number of the injection units 112 may be the same as the number of the reaction pads 130 disposed in the internal space S. When the specimen is injected into the injection unit 112, May be introduced into the inner space (S) through the injection unit (112).

The specimen which has flowed into the internal space S through the injection unit 112 impregnates at least two reaction pads 130 disposed under the injection unit 112, 130 to the reaction zone 132 of the reaction zone.

That is, the sample collected from the blood or the like moves to the reaction region 132 of the reaction pad 130 by the chromatography after the lapse of a predetermined time and reacts. Hereinafter, the result of the reaction region 132 is referred to as a sample Reaction result (134).

In other words, when the specimen collected from the blood or the like is injected into the injection section 112 of the specimen analyzing kit 10, the specimen moves to the reaction zone 132 of the reaction pad 130 after a predetermined time passes And the result of the reaction region 132 can be defined as the sample reaction result 134. [

This is because a change occurs in the reaction region 132 due to the difference in the movement speed depending on the concentration of the analyte contained in the specimen on the reaction pad 130, 134).

As a specific example, the specimen may be an antigen and the result of the specimen reaction may be the result of an antigen-antibody reaction.

The antigen may be Myoglobin, Creatine Kinase-MB (CK-MB), Troponin I, Pro-BNP or D-dimer.

In addition, the antigen may be a tumor marker. For example, the tumor marker may be CA15-3, a recurrent breast cancer marker, CA19-9, a rectal cancer and pancreatic cancer marker, CA125, an ovarian cancer marker, CEA, which is a rectal cancer, lung cancer, pancreatic cancer, digestive cancer and breast cancer marker, PSA, which is a marker, or AFP, which is a liver cancer marker.

However, this is only one example, and various samples can be analyzed, and the result of the sample reaction can be varied.

Meanwhile, the sample reaction result 134 may be implemented as at least one kind of band shape, and the health state of the sample subject collected by analyzing the band can be analyzed.

Therefore, the reaction area 132 of the reaction pad 130 needs to expose the reaction area 132 to the outside so that the subject can identify the sample. For this purpose, the sample analysis kit 10 includes the display part 114, .

Specifically, the display unit 114 may be formed at a position adjacent to the injection unit 112, and may be a kind of hole that exposes at least two reaction areas 132 of the reaction pads 130.

The size of the reaction region 132 of the plurality of reaction pads 130 may be larger than the size of the reaction region 132 of the plurality of reaction pads 130. Therefore, As shown in FIG.

As described above, the reaction pad 130 may be arranged to correspond to the injection unit 112, and the sample introduced from each injection unit 112 may be subjected to mutual reaction without interfering with each other May be impregnated into the pad 130.

For example, when a specimen such as blood is injected into the injection section 112, the specimen penetrates through at least two injection sections 112 and impregnates the reaction pads 130, It is possible to simultaneously analyze the multi-characteristics of the specimen from the reaction result of the reaction region 132.

Here, in FIGS. 1 to 3, two reaction pads 130 and two injection units 112 are provided to obtain two kinds of sample reaction results from one sample injection, but the present invention is not limited thereto, The number of results can be varied variously by varying the number of injector 112 and reaction pads 130 (see FIGS. 4 and 5).

On the other hand, is introduced from the injection unit 112, the sample penetrates into each of the reaction pads 130 and the interfere leakage is to be prevented from happening to the accuracy of the sample reaction result, the reaction pad for this purpose (130) prevent leakage gap (S) while maintaining the gap (G).

As a result, the leakage gap G may mean a separation distance between the reaction pads 130 to prevent leakage of the sample.

Here, the leakage preventing gap GS may be formed to be 0.5 mm or more, and the conditions for preventing leakage are shown in Tables 1 to 5.

Width of reaction pad (mm) 3.8 The volume (μl) 220 230 240 250 260 Leakproof gap
(mm) 0.1 O O O O O 0.2 O O O O O 0.3 O O O O O 0.4 O O O O O 0.5 X X X O O 0.6 X X X O O 0.7 X X X X O 0.8 X X X X O 0.9 X X X X O 1.0 X X X X O

Width of reaction pad (mm) 3.9 The volume (μl) 220 230 240 250 260 Leakproof gap
(mm) 0.1 O O O O O 0.2 O O O O O 0.3 O O O O O 0.4 O O O O O 0.5 X X O O O 0.6 X X X X O 0.7 X X X X O 0.8 X X X X O 0.9 X X X X X 1.0 X X X X X

Width of reaction pad (mm) 4 The volume (μl) 220 230 240 250 260 Leakproof gap
(mm) 0.1 O O O O O 0.2 O O O O O 0.3 O O O O O 0.4 O O O O O 0.5 X X X X O 0.6 X X X X X 0.7 X X X X X 0.8 X X X X X 0.9 X X X X X 1.0 X X X X X

Width of reaction pad (mm) 4.1 The volume (μl) 220 230 240 250 260 Leakproof gap
(mm) 0.1 O O O O O 0.2 O O O O O 0.3 O O O O O 0.4 O O O O O 0.5 X X X O O 0.6 X X X X O 0.7 X X X X X 0.8 X X X X X 0.9 X X X X X 1.0 X X X X X

Width of reaction pad (mm) 4.2 The volume (μl) 220 230 240 250 260 Leakproof gap
(mm) 0.1 O O O O O 0.2 O O O O O 0.3 O O O O O 0.4 O O O O O 0.5 X X O O O 0.6 X X X X X 0.7 X X X X X 0.8 X X X X X 0.9 X X X X X 1.0 X X X X X

As shown in Tables 1 to 5, when the width of the reaction pad 130, the volume of the sample to be injected, and the gap G for preventing leakage were measured, it was determined whether or not the interference due to the leakage occurred. "O" if no leakage occurred more than 95 times, and "X" if not.

It is noted that the width of the reaction pad 130 is limited within a range that can be disposed in the inner space S of the case 100 in consideration of the overall size of the case 100. [

Referring to Tables 1 to 5, the total volume of specimens injected into at least two reaction pads 130 is within an error range of ± 20 μl based on 240 μl, and the width of at least two of the reaction pads is When the error is within ± 2.0 mm of 4.0 mm, the leak-barrier gap should be 0.5 mm or more to prevent water leakage during multi-measurement of the sample, thereby preventing interference.

Specifically, in order to maximize the efficiency of water leakage prevention in multi-measurement of a specimen, it is preferable that the water leakage prevention gap G is 0.7 mm or more under the above conditions.

On the other hand, when the total volume of the specimen injected into at least two of the reaction pads 130 is within a range of 220 이상 to 240 에는, the width of at least two of the reaction pads 130 is within a range of 3.8 mm to 3.9 mm As shown in FIG.

When the total volume of the specimen injected into at least two reaction pads 130 is within the range of 220 이상 to 250 에는, the width of at least two of the reaction pads 130 is in a range of 4.0 mm to 4.2 mm As shown in FIG.

When the total volume of the specimen injected into at least two of the reaction pads 130 is 260 mu l, the width of at least two of the reaction pads 130 is within a range of 4.0 mm to 4.2 mm, The gap G is preferably formed to be 0.6 mm or more.

In order to arrange the reaction pad 130 in the internal space S while maintaining at least two reaction pads 130 satisfying the above conditions, (Not shown).

Specifically, the fixing wall 122 may protrude from the bottom surface of the receiving portion 120 toward the internal space S, and may be formed around the injecting portion 112 so as to be shifted from the injecting portion 112 .

That is, the fixed wall 122 supports one end and the other end of each reaction pad 130 while surrounding the reaction pad 130 to fix the reaction pad 130 at a position corresponding to the injection unit 112, It is possible to stably maintain the leakage preventing gap G for preventing the leakage.

Therefore, according to the sample analyzing kit 10 according to the present invention, it is possible to simultaneously analyze the multi-characteristics of the sample by inputting a single sample, and to prevent leakage and interference of the sample during the simultaneous analysis of the multi- It is possible to prevent a phenomenon beforehand and to obtain a more accurate analysis result.

However, the fixing wall 122 is not limited to being spaced apart from a part of the receiving portion 120 corresponding to one end and the other end of each reaction pad 130, It may be formed continuously from one end to the other end.

The reaction pad 130 disposed in the inner space S may be provided with a pressing force by at least one pressing protrusion 116. The pressing protrusion 116 may protrude from the upper inner side surface of the cover portion 110 And may protrude toward the inner space S.

That is, the pressing protrusions 116 may be formed to correspond to the spaces between the fixing walls 122 to press one surface of the reaction pad 130, and the pressing portion may be formed outside the reaction area 132 of the reaction pad 130 Lt; / RTI >

Accordingly, the reaction pad 130 is pressed by the pressing protrusion 118 which presses the portion other than the reaction region 130 without affecting the reaction region 130, which is a region showing the sample reaction result 134 It can be more stably fixed in the internal space S.

The cover 110 and the receiving part 120 constituting the case 100 may be fastened to each other by at least one fastening part 118 and at least one fastening corresponding part 128, (118) and the fastening corresponding portion (128) can be fastened by interference fit.

In other words, the coupling part 118 may protrude from the inner upper side of the cover part 110 in the shape of a protrusion, and the coupling corresponding part 128 may be formed in a shape of a groove from the bottom surface of the receiving part 120 As shown in Fig.

Therefore, the cover 110 and the receiving part 120 can be fastened to each other by being tightly fitted to the fastening part 128, and the fastening part 118 can be fastened to the fastening part 118, The corresponding portions 128 may be formed at positions opposite to each other.

On one side and the other side of the cover 110, an identification code 111 and a rib 113 for obtaining information on the reaction result between the specimen and the reaction pad 130 may be provided.

Here, the identification code 111 may mean information including a separate code value necessary for obtaining valid information on the specimen reaction result.

For example, the identification code 111 may be manufacturing lot information of the kit for analyzing a sample 10 according to the present invention.

The production lot information of the sample analyzing kit 10 can be used to calibrate the reading result of the sample reaction result.

As another example, the identification code 111 may be an expire date of the kit 10 for analyzing a specimen. An identification code 111 including an effective date can be used to determine whether to use the sample analyzing kit 10 or not.

The identification code 111 may be varied as a barcode, a color pattern, a number or a letter, and the sample analyzing kit 10 provided with a sample reaction result and an identification code 111 on one side may be used as a camera (Not shown), and obtain the analysis result of the specimen based on the image photographed by the camera.

In other words, when the sample analyzing kit 10 according to the present invention is inserted into the measuring apparatus to obtain the analysis result of the sample, the identification code 111 is first taken by the camera in the initial insertion step, and when the insertion is completed The camera captures a specimen reaction result 134 appearing on the display unit 114.

Thereafter, the control unit analyzes the reading result of the sample reaction result 134 by using the reading result of the image of the identification code 111, and outputs the analysis result.

Specifically, when the identification code 111 is the production lot information of the sample analysis kit 10, the control unit calibrates the reading result of the sample reaction result using the production lot information read out from the identification code 111.

On the other hand, when the identification code 111 is an expiration date of the kit 10 for analysis, the control unit outputs an error message when the effective date has elapsed in accordance with the result of reading the identification code 111.

When the identification code 111 indicates the type of the specimen to be analyzed in the specimen analyzing kit 10, the control unit determines whether the type of specimen to be analyzed according to the readout result of the photographed identification code 111 is a specimen If it does not correspond to the type, an error message indicating that analysis is impossible can be output.

Meanwhile, the ribs 113 may be a kind of anti-slip structure for preventing slippage when the sample analyzing kit 10 according to the present invention is inserted into the measuring device (not shown).

FIG. 4 is a schematic perspective view illustrating a sample analyzing kit according to another embodiment of the present invention, FIG. 5 is a schematic exploded perspective view illustrating a sample analyzing kit according to an embodiment of the present invention, FIG. FIG. 1 is a schematic plan view showing a receiving unit provided in a sample analyzing kit according to an embodiment of the present invention.

4 to 6, the sample analyzing kit 20 according to the embodiment of the present invention may include a sample analyzing kit 20, except for the number of the injecting unit 212, the reaction pad 230 and the fixing wall 222 1 to FIG. 3, the description and description of components other than the components will be omitted. FIG. 3 is a perspective view of a sample analyzing kit 10 according to an embodiment of the present invention.

The kit for analyzing a specimen 20 according to an embodiment of the present invention includes three injection units 212 and three reaction pads 230 formed in the cover unit 210 of the case 200 and is provided with three And three reaction characteristics of the specimen can be simultaneously analyzed by the respective reaction pads 230.

For this, the three reaction pads 230 may be fixed to the inner space S by a plurality of fixing walls 222 formed on the receiving portion 220.

As a result, the number of the fixing walls 222 can be variously changed according to the number of the injection units 212 and the reaction pads 230.

That is, the number of the injection part 212 and the reaction pad 230 may be three or more, and the number of the fixing walls 222 may vary.

In addition, the reaction pad 230 can be stably fixed in the internal space S by the fixing wall 222 while maintaining the leakage gap G.

While the present invention has been described with reference to exemplary embodiments, it is to be understood that the invention is not limited to the disclosed exemplary embodiments, but, on the contrary, It will be apparent to those skilled in the art that changes or modifications may fall within the scope of the appended claims.

10, 20: Kit for sample analysis
100, 200: Case
110, 210:
120. 220:
130, 230: reaction pad
G: Leakage prevention gap

Claims (10)

A kit for analyzing a specimen, wherein a specimen is permeated into at least two reaction pads and a result of a specimen reaction by each of the reaction pads is shown,
The reaction pad is disposed to have a leakage prevention gap between the other reaction pads to prevent leakage of the sample,
The leak prevention gap is a sample analysis kit that is formed to more than 0.5mm.
The method of claim 1,
When the total volume of the specimens injected into at least two reaction pads is within an error range of ± 20 μl based on 240 μl,
At least two or more width of the reaction pad is a sample analysis kit having an error range of ± 2.0mm based on 4.0mm.
3. The method of claim 2,
The leak prevention gap is a sample analysis kit is formed in more than 0.7mm.
The method of claim 1,
When the total volume of the specimen to be injected into at least two reaction pads is within a range from 220 ㎕ to 240,,
And a width of at least two of the reaction pads is within a range of 3.8 mm or more and 3.9 mm or less.
The method of claim 1,
When the total volume of the specimen to be injected into at least two reaction pads is within a range from 220 쨉 l to 250 쨉 l,
Wherein a width of at least two of said reaction pads is within a range of 4.0 mm or more and 4.2 mm or less.
The method of claim 1,
When the total volume of the specimen injected into at least two reaction pads is 260 μl,
Wherein the width of at least two reaction pads is within a range of 4.0 mm to 4.2 mm, and the leakage preventing gap is 0.6 mm or more.
7. The method according to any one of claims 1 to 6,
An injection unit for injecting the sample into the at least two reaction pads, and a display unit for exposing the result of the sample reaction to the outside.
8. The method of claim 7,
And the injection unit is formed to communicate with the outside so as to correspond to each of the reaction pads.
9. The method of claim 8,
Wherein the case has a fixing wall for fixing at least two or more reaction pads inside the case while maintaining the leakage preventing gap.
10. The method of claim 9,
Wherein the fixing wall is formed in the periphery of the injection section and is formed to be offset from the injection section.

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