KR20130108824A - Cosmetic composition having stabilized fat soluble active material and method for fabricating the same - Google Patents

Abstract

PURPOSE: A composition for makeup is provided to stabilize a fat soluble active material in oil, to maximize stability of the fat soluble active material by a complex structure of a polymer capsule and a fluidic gel layer, and to effectively deliver the fat soluble material to skin. CONSTITUTION: A composition (100) for makeup contains: a fat soluble active material stabilizing solution (10A) in which a fat soluble active material is dissolved in oil; a polymer capsule (20) in which the fat soluble active material stabilizing solution is supported; and a fluidic gel layer (30) which is formed on the surface of the polymer capsule. A method for manufacturing the composition comprises the steps of: dissolving the fat soluble active material in oil and preparing the fat soluble active material stabilizing solution; mixing the fat soluble active material stabilizing solution with a solution in which polymers are dissolved and forming a polymer capsule by surfactant precipitation, in which the fat soluble active material stabilizing solution is supported; and mixing and dispersing the polymer capsule in a solution of soluble polymers and forming the fluidic gel layer.

Description

Cosmetic composition comprising stabilized fat-soluble active substance and a method for manufacturing the same {Cosmetic composition having stabilized fat soluble active material and method for fabricating the same}

The present invention relates to a stabilization technique of the active substance, and more particularly, to a cosmetic composition comprising a stabilized fat-soluble active substance and a method for producing the same.

Although many types of fat-soluble active substances are widely used in cosmetics for their good efficacy, such as improving skin wrinkles and strengthening moisture, they are easily discolored and / or odor due to exposure to the external environment such as air or moisture, and potency is reduced. There is a problem of this deterioration.

For example, fat-soluble active materials such as retinol and retinol derivatives are of great interest in their application due to their excellent anti-wrinkle efficacy, but due to their unstable properties which are easily destroyed by light, heat, air and moisture, Extremely limited In order to stabilize such retinol and retinol derivatives, stabilization technology using an antioxidant, physical adsorption technology using porous silica or phospholipid, stabilization technology using a capsule wall in a polymer polymerization method, and using one or more mammary liquid crystals Emulsification stabilization techniques, and techniques that have been stabilized by combining one or more of the above techniques have been proposed.

However, these conventional stabilization techniques have somewhat improved the stability of retinol and retinol derivatives, but have not reached satisfactory levels for stable and universal use in various cosmetic formulations. For example, in terms of stability, blocking of oxygen, ultraviolet rays, moisture, etc., which affect the oxidation promotion of retinol and retinol derivatives is not satisfactory, and toxicity such as skin irritation caused by excessive use of irritant antioxidants is expressed. There is a problem. In addition, in the case of the technique using the crosslinked capsule wall material, the active material inside the capsule can not flow out to the outside of the capsule wall material even though the stability is improved, so that the effect on the skin is not sufficiently performed in many cases.

Therefore, there is an urgent need for a new system that can not only improve stability in various cosmetic formulations, but also can be widely used in stabilization techniques for fat-soluble active substances that can effectively deliver efficacy to the skin.

Accordingly, the technical problem to be achieved by the present invention is to provide a cosmetic composition that can improve the efficacy on the skin by stabilizing the fat-soluble active substance, safety of skin irritation and the release of the fat-soluble active substance.

In addition, another technical problem to be achieved by the present invention is to provide a method for producing a cosmetic composition having the above-mentioned advantages.

Cosmetic composition according to an embodiment of the present invention for solving the above problems, fat-soluble active substance stabilization solution in which the fat-soluble active substance is dissolved in oil; A polymer capsule in which the fat-soluble active substance stabilization solution is supported; And it may include a fluid gel layer formed on the surface of the polymer capsule.

In some embodiments, the fat soluble active substance is retinol, retinol derivatives, retinyl acetate, retinyl palmitate, tocopherol, tocopheryl acetate, tocopherillinolate, tocopheryl nicotinate, epigallocatechin gallate, alpha Lipoic acid, linoleic acid, coenzyme Q-10, resveratrol, hyaluronic acid, plant extract essential oils, and derivatives thereof, or combinations thereof. In addition, the fat-soluble active material stabilization solution may include as much as 0.1 to 100 parts by weight of the fat-soluble active material with respect to 100 parts by weight of the oil. Further, in some embodiments, the content of the fat-soluble active substance stabilization solution relative to the total weight of the polymer capsule and the fat-soluble active substance stabilization solution may be 0.1 to 90 parts by weight.

In some embodiments, the polymer may include any one or a combination of Polymethylmethacrylate, Poly (methacylic acid-co-methyl methacrylate), Poly (lactic acid), and Poly (caprolactone) having a molecular weight of 10,000 to 200,000. . In addition, in some embodiments, the oil is avocado oil, wheat germ oil, rose hip oil, almond oil, olive oil, sesame oil, black sesame oil, castor oil, camellia oil, safflower oil, soybean oil, rapeseed oil, blooming oil, cottonseed oil Plant extract oils selected from peanuts, macadamia nut oil, jojoba oil, palm oil, palm kernel oil, coconut oil, rice bran oil and grape seed oil; Wax selected from beeswax, carnauba wax, candelilla wax, lanolin; Hydrogenated oil selected from castor hardened oil, rapeseed hardened oil, palm hardened oil; And a barrier material selected from lipids, essential fatty acids and lipid complexes; Any one or a combination thereof.

The oil-soluble active substance stabilizing solution may further include any one or a combination of antioxidants, sunscreens and skin irritants dissolved with the fat-soluble active substance. In some embodiments, the antioxidant agent is selected from among tocopheryl acetate, gamma-oryzanol, sesamol, alpha lipoic acid, linoleic acid, nordihydroguaiaretic acid, prokigallate, epigallocatechin gallate and derivatives thereof. It may also include any one or a combination thereof. The sunscreen may include any one or combination of inorganic ultraviolet scatterers, organic ultraviolet absorbers, and natural gamma ultraviolet absorbers. In addition, the skin irritant may include any one or a combination of gamma-rijanol, rice bran oil, black sesame oil, aspirin, extract extract, allantoin, peppermint extract, chamomile extract, Geumchocho extract, camellia extract and derivatives thereof. have. In some embodiments, the fat-soluble active substance stabilizing solution may include 0.1 to 100 parts by weight of any one or two or more of the antioxidant, the sunscreen and the skin irritant based on 100 parts by weight of the oil.

The fluidized gel layer may include a water-soluble polymer. The water-soluble polymers are queens seed gum, xanthan gum, carboxymethyl cellulose sodium, carboxyvinyl polymer, polyvinyl alcohol, polyvinylpyrrolidone, arabian gum, guar gum, karaya gum, carrageenan, tragacanth gum, sodium hyaluronate, Locust bean gum, agar, gelatin, casein, dextrin, pectin, starch and derivatives thereof, or combinations thereof.

Method for producing a cosmetic composition according to an embodiment of the present invention for solving the other problems, the first step of preparing a fat-soluble active substance stabilizing solution by dissolving the fat-soluble active substance in oil; A second step of mixing the fat-soluble active material stabilization solution of the first step into a solution in which the polymer polymer is dissolved and then forming a polymer capsule in which the fat-soluble active material stabilization solution is carried by interfacial precipitation; And a third step of mixing and dispersing the polymer polymer capsule carrying the fat-soluble active material of the second step in an aqueous solution of the water-soluble polymer to form a fluidized gel layer.

The first step may further include dissolving any one or a combination of antioxidants, sunscreens and skin irritation stabilizers in the oil. In some embodiments, the oil-soluble active substance may be dissolved after dissolving any one or a combination of the antioxidant, the sunscreen and the skin stimulating stabilizer in the oil.

In some embodiments, the fat-soluble active substance stabilization solution may include 0.1 to 100 parts by weight of any one or two or more of the fat-soluble active substance, antioxidant, sunscreen and skin irritation stabilizer for the oil. The interfacial precipitation method may include preparing a dispersed phase in which a fat-soluble active material stabilization solution is uniformly mixed with a solution in which the polymer polymer is dissolved; Dissolving the surfactant in water to prepare a continuous phase; Preparing an emulsion by adding the dispersed phase to the continuous phase; And drying the emulsion to prepare the polymer capsule.

According to an embodiment of the present invention, the fat-soluble active substance is stabilized in oil, and the stability of the fat-soluble active substance is maximized and effectively delivered to the skin by the composite structure of the polymer capsule and the flowable gel layer. In addition, optionally, one or a combination of antioxidants, sunscreens, and skin irritants that are dissolved together with the fat-soluble active substance may enhance the stabilization of the fat-soluble active substance, and improve safety against skin irritation. Cosmetic compositions may be provided.

1 and 2 are cross-sectional views showing the structure of a cosmetic composition according to various embodiments of the present invention.

Hereinafter, the present invention will be described in more detail with reference to the following examples, but the following examples are only for illustrating the present invention, and the scope of the present invention is not limited thereto.

The embodiments of the present invention are described in order to more fully explain the present invention to those skilled in the art, and the following embodiments may be modified into various other forms, It is not limited to the embodiment. Rather, these embodiments are provided so that this disclosure will be more faithful and complete, and will fully convey the scope of the invention to those skilled in the art.

In the drawings like reference numerals refer to like elements. In addition, as used herein, the term "and / or" includes any and all combinations of one or more of the listed items.

Also, the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the scope of the invention. In addition, although described in the singular in this specification, a plural form may be included unless the singular is clearly indicated in the context. Also, as used herein, the terms "comprise" and / or "comprising" specify the shapes, numbers, steps, actions, members, elements and / or presence of these groups mentioned. It does not exclude the presence or addition of other shapes, numbers, operations, members, elements and / or groups.

In the following, embodiments of the present invention will be described with reference to cross-sectional views schematically showing ideal embodiments (and intermediate structures) of the present invention. In these figures, for example, the size and shape of the members may be exaggerated for convenience and clarity of explanation, and in actual implementation, variations of the illustrated shape may be expected. Accordingly, embodiments of the present invention should not be construed as limited to any particular shape of the regions shown herein. In addition, reference numerals of members in the drawings refer to the same members throughout the drawings.

1 and 2 are cutaway cross-sectional views schematically showing the structure of the cosmetic composition (100, 200) according to various embodiments of the present invention.

Referring to FIG. 1, the cosmetic composition 100 according to one embodiment includes a fat-soluble active substance stabilization solution 10A, 10B; A polymer capsule 20 carrying a fat-soluble active substance stabilization solution 10; And a flowable gel layer 30 formed on the surface of the polymer capsule 20. In some embodiments, the cosmetic composition 200 may further comprise a functional material, such as a sunscreen material 40, in the polymeric capsule 20, as shown in FIG. 2.

Spherical shapes of the compositions 100 and 200 shown in FIGS. 1 and 2 are exemplary, but the present invention is not limited thereto. For example, by modifying the shape of the polymer capsule 20, the compositions 100 and 200 can have various shapes such as ellipsoid, potato or rice grains.

Fat-soluble active substance stabilization solution

The fat soluble active substance stabilization solution 10 includes a fat soluble active substance dissolved in an oil which is a solvent. In some embodiments, the fat soluble active substance stabilization solution 10 may further include an antioxidant along with the fat soluble active substance. In addition, any one or a combination of sunscreen and skin irritant may be further added with these materials. FIG. 1 shows a fat-soluble active substance stabilization solution 10A in which an oil-soluble active substance is dissolved in oil, and FIG. 2 further shows an antioxidant, a sunscreen and a skin irritant in addition to the fat-soluble active substance. The fat-soluble active substance stabilization solution 10B is disclosed. The fat-soluble active substance stabilization solutions 10A and 10B are solutions in which the fat-soluble active substance is stabilized so as to prevent oxidation of the fat-soluble active substance and reduce irritation to the skin, depending on the additive substance.

In some embodiments, the fat soluble active substance is retinol, retinol derivatives, retinyl acetate, retinyl palmitate, tocopherol, tocopheryl acetate, tocopherillinolate, tocopheryl nicotinate, epigallocatechin gallate, alpha Lipoic acid, linoleic acid, coenzyme Q-10, resveratrol, hyaluronic acid, plant extract essential oils and derivatives thereof or combinations thereof. The fat-soluble active substance may be selected from materials suitable as a raw material of the cosmetic composition, such as skin wrinkle improvement and strengthening moisturizing.

In some embodiments, the antioxidant agent is selected from among tocopheryl acetate, gamma-oryzanol, sesamol, alpha lipoic acid, linoleic acid, nordihydroguaiaretic acid, prokigallate, epigallocatechin gallate and derivatives thereof. It may be any one or a combination thereof. In some embodiments, the skin irritant may be a substance having a skin calming effect by anti-inflammatory or anti-allergic action. For example, the skin irritant may be any one or a combination of gamma-rijanol, rice bran oil, black sesame oil, aspirin, extract extract and allantoin. These materials are exemplary only and the present invention is not limited thereto. For example, the skin irritant may be a plant extract such as peppermint extract, chamomile extract, geumchocho extract or camellia extract.

The sunscreen may include inorganic ultraviolet scatterers that absorb or scatter ultraviolet rays, organic ultraviolet absorbers that absorb ultraviolet rays and convert energy into various forms such as heat, waves, fluorescence, and radicals, natural ultraviolet absorbers, and combinations thereof. have. The inorganic ultraviolet scattering agent may include a metal oxide such as titanium oxide, zinc sulfide, cerium oxide, aluminum oxide, barium titanium oxide, or a metal salt such as calcium carbonate, calcium oxide, or kaolin, or monoatomic metal or alloy. . The organic sunscreen agent is ethylhexyl methoxycinnamate, butyl methoxydibenzoylmethane, ethylhexyl triazone, ethromexyl triazone, drometizole, benzophenone-3 , Benzophenone-4, Benzophenone-8, Cinoxate, Octocrylene, Ethylhexyl Salicylate, Homosalate And any one or combinations thereof.

The natural sunscreen agent may include any one or a combination of a phenolic acid compound and the flavonoid compound. The phenolic acid compound, ferulic acid (ferulic acid), caffeic acid (caffeic acid), coumaric acid (coumaric acid), alpha cyanohydroxyhydroxynamic acid (Alpha-cyano-4-hydroxycinnamic acid), chicory acid ( Cichoric acid, Cinnamic acid, Chlorogenic acid, Caftaric acid, Coutaric acid, Fertaric acid, Deferulic acid ), Sinapic acid, and derivatives thereof, and any one or combination thereof. In addition, the flavonoid-based compound, quercetin (quercetin), camphorol (kaempherol, apigenin), luteolin (Luteolin), myricetin (tangricetin), Tangerine (Tangeritin (4 ', 5, 6, 7) , 8-pentamethoxyflavone)), chrysin (5,7-OH), baicalein (5,6,7-trihydroxyflavone), and cutellarein (5,6,7,4'-tetrahydroxyflavone) )), Wogonin (5,7 -OH, 8 -OCH3), azeleatin, fisetin, galangin, gossypetin, kaempferide Isorhamnetin, Morin, Natsudaidain, Pachypodol, Rhamnazin, Rhamnetin, Astragalin, Azalein ), Hyperside, Isoquercitin, Kaempferitrin, Myricitrin, Quercitrin, Robinin, Rutin, Spireo Spiraeoside, Xanthorhamnin, Amu It may include any one selected from the group consisting of Amurensin, Icariin, Troxerutin, and derivatives thereof, or a combination thereof.

In some embodiments, the oil is avocado oil, wheat germ oil, rosehip oil, almond oil, olive oil, sesame oil, black sesame oil, castor oil, camellia oil, safflower oil, soybean oil, rapeseed oil, fig oil, cottonseed oil, peanut Botanical extract oils selected from bovine, macadamia nut oil, jojoba oil, palm oil, palm kernel oil, coconut oil, rice bran oil and grape seed oil; Wax selected from beeswax, carnauba wax, candelilla wax, lanolin; Hydrogenated oil selected from castor hardened oil, rapeseed hardened oil, palm hardened oil; And barrier materials selected from lipids such as ceramides, essential fatty acids and lipid complexes; Any one or a combination thereof. When such a natural extract is used as a solvent of a stabilization solution for stabilizing a fat-soluble active substance, safety against skin irritation can be ensured. In another embodiment, depending on the type of oil used, the oil itself may have antioxidant, anti-irritant or sunscreen effects, in which case any one of the aforementioned antioxidants, sunscreens and skin irritation stabilizers may be omitted. Could be

The fat-soluble active substance stabilization solution 10 may be prepared by dissolving any one or a combination of antioxidants, sunscreens and skin irritation stabilizers in the oil, and then dissolving the fat-soluble active substance. In some embodiments, the fat soluble active material stabilization solution 10 may include from 0.1 to 100 parts by weight of the fat soluble active material based on 100 parts by weight of oil. In addition, when any one or two or more of an antioxidant, a sunscreen and a skin irritant are included in the fat-soluble active substance stabilizing solution 10, each of them may be dissolved by 0.1 to 100 parts by weight based on 100 parts by weight of oil. .

Polymer Capsule

In some embodiments, the polymer used to form the polymer capsule 20 carrying the fat soluble active material stabilization solution 10 has a molecular weight of 10,000 to 200,000, and is polymethylmethacrylate, Ammonio Methacrylate Copolymer, Poly (lactic acid) And Poly (caprolactone), or a combination thereof. The polymer capsule 20 prevents penetration of oxygen and moisture from outside and serves to block leakage of the fat-soluble active material stabilization solution 10 into the external environment.

The content of the fat-soluble active substance stabilization solution 10 relative to 100 parts by weight of the polymer capsule 20 may be 0.1 to 95 parts by weight. As described above, the polymer capsule 20 may include a sunscreen, and in this case, UV penetration may be blocked into the UV active material stabilization solution 10, thereby preventing denaturation of the UV active material stabilization solution 10. can do. In other embodiments, the sunscreen may be dispersed in the fat soluble active material stabilization solution 10. For example, the inorganic magnetic line scattering agent may be dispersed in the polymer capsule 20, and the organic sunscreen agent or the natural sunscreen agent may be dispersed in the fat-soluble active material stabilization solution 10.

Fluid Gel layer

The fluid gel layer 30 may include a water-soluble polymer, wherein the water-soluble polymer is queen's gum, xanthan gum, carboxymethyl cellulose sodium, carboxyvinyl polymer, polyvinyl alcohol, polyvinylpyrrolidone, arabian gum, guar gum, Karaya gum, carrageenan, tragacanth gum, sodium hyaluronate, locust bean gum, agar, gelatin, casein, dextrin, pectin, starch and derivatives thereof, or combinations thereof. The flowable gel layer 30 may be included in an amount of 10 to 500 parts by weight based on 100 parts by weight of the polymer capsule 20.

The fluid gel layer 30 is formed on the surface of the polymer capsule 20. Since the fluid gel layer 30 includes an aqueous phase, the fat-soluble active material stabilization solution 10 in the polymer capsule 20 can be stably supported. When the molecular weight of the polymer constituting the polymer capsule 20 is 10,000 or less, a large amount of molecular voids in the polymer polymer capsule wall occurs compared to the same amount, so that the cosmetic formulation is out of the capsule 20 due to the osmotic pressure of the oil component present outside the capsule. Liquid phase outflow of the remarkable, and when the molecular weight is more than 200,000, the solubility of the polymer in the organic solvent is rapidly reduced and encapsulation is difficult to proceed. In addition, as the molecular weight increases, the critical thickness of the capsule wall also increases, making it difficult to form micro-sized particles or thinner capsule walls. The fluidized gel layer 30 may limit the leakage of the fat-soluble active substance stabilization solution 10 from the polymer capsule 20 even when the molecular weight is 200,000 or less, and even when the polymer is less than 10,000, the polymer capsule ( 20) It is possible to broaden the material selection and to stably support the fat-soluble active substance stabilization solution 10 in the polymer capsule 20. In addition, since the fluidized gel layer 30 has a low oxygen solubility thereof, the fluidized gel layer 30 may act as an oxygen filter to block oxygen transfer from the outside to the polymer capsule 20, thereby suppressing degeneration of the fat-soluble active substance due to oxygen infiltration. have.

Process for preparing fat-soluble active substance stabilization solution

The preparation of the cosmetic composition dissolves the fat-soluble active substance in oil and, optionally, further adds an antioxidant, or, optionally, one or a combination of sunscreen and skin irritant, to the oil. Thereby preparing a fat-soluble active substance stabilization solution; Mixing the fat-soluble active material stabilization solution of the first step into a solution in which the polymer polymer is dissolved, and then forming a polymer capsule containing the fat-soluble active material stabilization solution by interfacial precipitation; And a third step of forming a fluidized gel layer by mixing and dispersing the polymer polymer capsule carrying the fat-soluble active material stabilization solution of the second step into an aqueous solution of a water-soluble polymer.

In the first step of preparing the cosmetic composition, the fat-soluble active substance may be dissolved by 0.1 to 100 parts by weight based on 100 parts by weight of the oil. In some embodiments, a combination of any of antioxidants, sunscreens and emollients is first dissolved in the oil and then the fat-soluble active substance is dissolved in the oil. The antioxidant, the sunscreen and the skin irritant have low solubility in oil compared to the fat-soluble active substance and require a long time or a temperature increase during the stirring process. Therefore, after dissolving the above-mentioned additives after dissolving the oil-soluble active substance in the oil, there is a problem that the titer is reduced due to the modification of the fat-soluble active substance by the stirring process and the heating process. In this case, the fat-soluble active substance stabilization solution may be dissolved by 0.1 to 100 parts by weight of any one or two or more of the antioxidant, the sunscreen and the skin irritant based on 100 parts by weight of oil.

In the second step of preparing the cosmetic composition, the fat-soluble active material stabilization solution of the first step is mixed with a solution in which the polymer is dissolved, and then the polymer polymer capsule in which the fat-soluble active material stabilization solution is supported by the interfacial precipitation method. It may be to form.

The interfacial precipitation method includes preparing a dispersed phase in which a fat-soluble active substance stabilizing solution is uniformly mixed with a solution in which a polymer polymer is dissolved; Dissolving the surfactant in water to prepare a continuous phase; Adding an dispersed phase to the continuous phase to prepare an emulsion; And drying the emulsion to prepare a polymer capsule.

The solution in which the polymer polymer used in preparing the dispersed phase is dissolved may be a solvent having low solubility in the polymer due to its low miscibility with water. For example, dichloromethane, dichloroethane, chloroform, tetrachloro Halogenated hydrocarbons such as methane, tetrahydrofuran; Esters such as ethyl acetate, ethyl acetate, butyl acetate, fatty acid glycerin esters; It may be a ketone solvent such as acetone, methyl ethyl ketone, methyl butyl ketone, methyl isobutyl ketone.

The continuous phase may be prepared by completely dissolving a surfactant in water such as purified water or distilled water, and the surfactant may be gelatin, starch, hydroxyethyl cellulose carboxymethyl cellulose, polyvinylpyrrolidone, polyvinyl alkyl ether, poly Vinyl alcohol, polydimethylsiloxane / polystyrene block copolymer, sorbitan monooleate, glyceryl monostearate, polyoxyethylene losbitan monooleate, but the present invention is not limited thereto and other suitable nonionics Or ionic surfactants may be used.

As described above, after preparing the dispersed phase and the continuous phase, the dispersed phase may be charged into the continuous phase, and stirred vigorously to prepare an emulsion such that the individual size of the dispersed phase becomes 0.1 μm to 200 μm. Thereafter, when the solution is dried by evaporating and removing the solvent, precipitation of the polymer may occur at the interface of the emulsion, thereby preparing a polymer capsule having a size of 0.1 μm to 200 μm. At this time, when the solvent is completely removed to prepare the polymer capsule, it is possible to selectively separate only the polymer capsule prepared by applying a physical filter method using centrifugation and filter paper. The separated polymer capsules can be redispersed in water to wash the surfactant on the capsule surface and then re-separated through centrifugation and filtration.

The third step of preparing the cosmetic composition may include mixing and dispersing a polymer capsule containing a fat-soluble active material stabilization solution in an aqueous solution of a water-soluble polymer to form a fluidized gel layer. The aqueous solution of the water-soluble polymer may be prepared by heating water at 50 ° C. to 60 ° C., dissolving the water-soluble polymer therein and optionally further dissolving a preservative, and lowering the temperature to 30 ° C. or less. Into the prepared polymer capsules in an aqueous solution of can be uniformly dispersed with a stirrer.

The water-soluble polymers are queens seed gum, xanthan gum, cellulose, carboxymethyl cellulose sodium, carboxyvinyl polymer, polyvinyl alcohol, polyvinylpyrrolidone, aristoplex, carbopol, polyacrylate, alginic acid, arabian gum, guar gum, Any one or combination of gellan gum, karaya gum, carrageenan, tragacanth gum, sodium hyaluronate, locust bean gum, xanthan gum, chitosan, amigel, natrazole, agar, gelatin, casein, dextrin, pectin and starch It may be.

Hereinafter, features and advantages of the present invention will be described with reference to the above-described materials among the above-described embodiments and specific embodiments selected from the composition ratio range disclosed therein. The following disclosure is for illustrative purposes only and should not be construed as limiting the invention thereto.

[ Example  One]

1-1. Preparation of fat-soluble active ingredient stabilization solution

Oil for dissolving fat-soluble active substances, antioxidants, sunscreen, and skin irritant. About 44.86g of black sesame oil combines about 2.46g of gamma-orizanol with UV-blocking and skin-stimulating effects, and about 2.46g of antioxidant tocopheryl acetate. g and sesamol 2.46 g were added and stirred to dissolve completely. Thereafter, about 4.91 g of retinol, a fat-soluble active substance, was added thereto, stirred, and completely dissolved to prepare a retinol stabilizing solution.

1-2. Manufacture of Polymer Capsules Supported with Fat-Soluble Active Ingredients

About 57.14 g of polymethylmethacrylate (PMMA) having a molecular weight of about 40,000 as a polymer was added to 380 g of dichloromethane, a solubilizing solvent, and completely dissolved by stirring. The retinol stabilization solution prepared in 1-1 was added to a solution in which polyvinyl methacrylate was dissolved and uniformly mixed to prepare a dispersed phase used to prepare a capsule by interfacial precipitation.

About 17.83 g of polyvinyl alcohol as a surfactant was added to 594 g of purified water and completely dissolved to prepare a continuous phase used to prepare a capsule by interfacial precipitation.

The dispersion phase was introduced into a continuous phase and stirred for 5 minutes to prepare an emulsion in which the size of the dispersion phase was uniform to a certain degree. Then, the emulsion was transferred to a concentrator and decompressed at a bath temperature of about 40 ° C. to remove dichloromethane, which is a solvent of the polymer. Capsules were separated using a paper filter. The separated capsule was dispersed in about 400 g of purified water at about 40 ° C. with stirring for 10 minutes and filtered to remove the surface active agent on the surface of the capsule.

1-3. Fluid Gel layer formation

50g of polyvinyl methacrylate capsules prepared in 1-2 in 46.3g of purified water, about 0.1g of disodium EDTA as an ion blocking agent, about 0.1g of citric acid as an antioxidant supplement, about 3g of Tween80 as a surfactant, sodium hyaluronate as a water-soluble polymer 0.5 g, about 0.5 g of phenoxyethanol as a preservative was added thereto, and stirred for about 10 minutes to form a fluid gel layer on the surface of the polyvinyl methacrylate capsule, thereby preparing a cosmetic composition.

[ Example  2]

Cosmetic compositions were prepared in the same manner as in Example 1, except that VitaminA palmitate 1.7Mio IU / g of BASF was used as the active substance instead of retinol as the fat-soluble active substance.

[ Example  3]

A cosmetic composition was prepared in the same manner as in Example 1, except that Vitamin A acetate 1.5Mio IU / g of BASF was used as the active substance instead of retinol as the fat-soluble active substance.

[ Example  4]

A cosmetic composition was prepared in the same manner as in Example 1, except that the amount of the fat-soluble retinol was decreased from about 4.91 g to about 1.2 g, and the amount of black sesame oil was increased from about 44.86 g to about 48.57 g.

[ Example  5]

A cosmetic composition was prepared in the same manner as in Example 1, except that the amount of retinol, an oil-soluble active substance, was decreased from about 4.91 g to about 2.5 g and the amount of black sesame oil was increased from about 44.86 g to about 47.27 g.

[ Example  6]

A cosmetic composition was prepared in the same manner as in Example 1, except that Poly (methacylic acid-co-methyl methacrylate) having a molecular weight of 125,000 was used instead of PMMA as a polymer for capsule walls.

[ Example  7]

A cosmetic composition was prepared in the same manner as in Example 1, except that rice bran oil was used instead of black sesame oil.

[ Example  8]

Cosmetic compositions were prepared in the same manner as in Example 1, except that grapeseed oil was used instead of black sesame oil.

<Stability Evaluation>

In order to evaluate the stability of the cosmetic composition prepared in Examples 1 to 8, the stability at 50 ° C., which is an extreme condition than 40 ° C. which is a standard for evaluating stability of general cosmetics, was evaluated.

The stability as a polymer capsule itself carrying the fat-soluble active substance stabilization solution and the stability in the cosmetic O / W formulation were evaluated and the results are shown in Table 1 and Table 2, respectively. Table 1 shows the initial concentration retention of the polymer capsules loaded with the fat-soluble active substance stabilization solution, and Table 2 shows the initial concentration retention in the O / W formulation of the polymer capsules carrying the fat-soluble active substance stabilization solution. The O / W formulations used were commercially available guide formulas of 50C (BASF).

division Storage conditions 0 days 7 days 14 days 21st 28th Example 1 50 ℃ 100% 100% 100% 100% 98% Example 2 50 ℃ 100% 100% 100% 100% 99% Example 3 50 ℃ 100% 100% 100% 100% 99% Example 4 50 ℃ 100% 100% 100% 100% 99% Example 5 50 ℃ 100% 100% 100% 100% 99% Example 6 50 ℃ 100% 100% 100% 100% 98% Example 7 50 ℃ 100% 100% 100% 100% 98% Example 8 50 ℃ 100% 100% 100% 100% 98%

division Storage conditions 0 days 7 days 14 days 21st 28th Example 1 Formulation 50 ℃ 100% 100% 100% 100% 98% Example 2 Formulation 50 ℃ 100% 100% 100% 100% 99% Example 3 Formulation 50 ℃ 100% 100% 100% 100% 99% Example 4 Formulation 50 ℃ 100% 100% 100% 100% 99% Example 5 Formulation 50 ℃ 100% 100% 100% 100% 99% Example 6 Formulation 50 ℃ 100% 100% 100% 100% 98% Example 7 Formulation 50 ℃ 100% 100% 100% 100% 98% Example 8 Formulation 50 ℃ 100% 100% 100% 100% 98%

Referring to Table 1, when the cosmetic composition according to the above embodiments was stored for 28 days under storage conditions of 50 ° C., when the initial (0 day) concentration was 100%, all concentrations on the 28th day were 98 It can be seen that it is shown by more than%, showing excellent stability.

In addition, referring to Table 2, when the cosmetic composition according to the above embodiments was stored up to 28 days under the storage conditions of 50 ℃ in the cosmetic O / W formulation, when the initial (0 day) concentration is 100% , The concentration on the 28th day was all 98% or more, showing excellent stability.

While the foregoing embodiments illustrate the benefits of the present invention in terms of stability, this is illustrative and the person skilled in the art will appreciate the other effects of the cosmetic composition with a fat-soluble active substance stabilizing solution and a polymer capsule, such as skin It is to be understood that the safety to and the inherent efficacy of the cosmetic composition may be better expressed and the present invention should not be limited by these listed effects. In addition, it should be understood that the cosmetic composition may also achieve other pharmacological effects depending on the fat-soluble active substance supported therein.

In addition, those skilled in the art, in addition to cosmetics by the effects such as skin wrinkle improvement, moisturizing, etc. of the fat-soluble active substance, other cosmetic applications such as soaps, shampoos and skin, scalp and drinking, detergents, pharmaceuticals, food and It is to be understood that the beverages and the like are also included in the present invention. In addition, various particles according to an embodiment of the present invention is a cosmetic base component of O / W (oil / water) type, W / O (water / oil) type, W / S (water / silicon) type, oil or moisture type And may be formulated into creams, emulsions, milk lotions, skins, and lotions as cosmetic compositions. The composition described above with respect to the total weight of the cosmetic composition may be included in the range of 0.1 parts by weight to 25 parts by weight. Preferably, the content of the particles may be in the range of 0.5 parts by weight to 5 parts by weight.

Claims (23)

A fat-soluble active substance stabilization solution in which the fat-soluble active substance is dissolved in oil;
A polymer capsule in which the fat-soluble active substance stabilization solution is supported; And
Cosmetic composition comprising a flow-type gel layer formed on the surface of the polymer capsule. The method of claim 1,
The fat-soluble active substance is retinol, retinol derivatives, retinyl acetate, retinyl palmitate, tocopherol, tocopheryl acetate, tocopheryl oleate, tocopheryl nicotinate, epigallocatechin gallate, alpha lipoic acid, linoleic acid , Coenzyme Q-10, resveratrol, hyaluronic acid, plant extract essential oils and derivatives thereof, any one or a combination thereof. The method of claim 1,
The oil-soluble active substance stabilizing solution is a cosmetic composition, characterized in that containing from 0.1 to 100 parts by weight of the fat-soluble active substance, based on 100 parts by weight of the oil. The method of claim 1,
The oils include avocado oil, wheat germ oil, rose hip oil, almond oil, olive oil, sesame oil, black sesame oil, castor oil, camellia oil, safflower oil, soybean oil, rape blossom oil, fish oil, cottonseed oil, peanut oil, macadamia nut oil Plant extract oils selected from jojoba oil, palm oil, palm kernel oil, coconut oil, rice bran oil and grape seed oil; Wax selected from beeswax, carnauba wax, candelilla wax, lanolin; Hydrogenated oil selected from castor hardened oil, rapeseed hardened oil, palm hardened oil; And a barrier material selected from lipids, essential fatty acids and lipid complexes; Cosmetic composition comprising any one or a combination thereof. The method of claim 1,
Cosmetic composition, characterized in that it further comprises any one or a combination of antioxidants, sunscreens and skin irritants in the fat-soluble active substance stabilization solution with the fat-soluble active substance. The method of claim 5, wherein
The antioxidant may be any one or a derivative of tocopheryl acetate, gamma-oryzanol, sesamol, alpha lipoic acid, linoleic acid, nordihydroguaialetic acid, prokigallate, epigallocatechin gallate and derivatives thereof. Cosmetic composition comprising a combination. The method of claim 5, wherein
The sunscreen is a cosmetic composition, characterized in that it comprises any one or a combination of inorganic ultraviolet scattering agent, organic ultraviolet absorber and natural gamma UV absorber. The method of claim 5, wherein
The skin irritant may include any one or a combination of gamma-rijanol, rice bran oil, black sesame oil, aspirin, extract extract, allantoin, peppermint extract, chamomile extract, geumchocho extract, camellia extract and derivatives thereof. Cosmetic composition. The method of claim 5, wherein
The oil-soluble active substance stabilization solution is a cosmetic composition, characterized in that it comprises 0.1 to 100 parts by weight of any one or two or more of the antioxidant, sunscreen and skin irritant based on 100 parts by weight of the oil. The method of claim 1,
The polymer is a cosmetic composition characterized in that it comprises any one or a combination of Polymethylmethacrylate, Poly (methacylic acid-co-methyl methacrylate), Poly (lactic acid) and Poly (caprolactone) having a molecular weight of 10,000 to 200,000 . The method of claim 1,
The flowable gel layer is a cosmetic composition, characterized in that it comprises a water-soluble polymer. The method of claim 11,
The water-soluble polymers are queens seed gum, xanthan gum, carboxymethyl cellulose sodium, carboxyvinyl polymer, polyvinyl alcohol, polyvinylpyrrolidone, arabian gum, guar gum, karaya gum, carrageenan, tragacanth gum, sodium hyaluronate, A cosmetic composition comprising any one or a combination of locust bean gum, agar, gelatin, casein, dextrin, pectin, starch and derivatives thereof. The method of claim 1,
The content of the fat-soluble active substance stabilization solution relative to 100 parts by weight of the polymer capsule is 0.1 to 95 parts by weight cosmetic composition. The method of claim 1,
The amount of the flowable gel layer based on 100 parts by weight of the polymer haptic capsule is 10 to 500 parts by weight of the cosmetic composition. A first step of dissolving the fat-soluble active substance in oil to prepare a fat-soluble active substance stabilizing solution;
A second step of mixing the fat-soluble active material stabilization solution of the first step into a solution in which the polymer polymer is dissolved and then forming a polymer capsule in which the fat-soluble active material stabilization solution is carried by interfacial precipitation; And
A method for producing a cosmetic composition comprising a third step of forming a fluid gel layer by mixing and dispersing the polymer polymer capsule carrying the fat-soluble active material of the second step in an aqueous solution of a water-soluble polymer. The method of claim 15,
The first step further comprises the step of dissolving any one or a combination of antioxidants, sunscreens and skin irritation stabilizers in the oil. 17. The method of claim 16,
A method for producing a cosmetic composition, characterized in that the oil-soluble active substance is dissolved after dissolving any one or a combination of the antioxidant, the sunscreen and the skin stimulating stabilizer in the oil. 17. The method of claim 16,
The fat-soluble active substance stabilization solution of the cosmetic composition, characterized in that it comprises 0.1 to 100 parts by weight of any one or two or more of the fat-soluble active substance, antioxidant, sunscreen and skin irritation stabilizer to the oil Manufacturing method. The method of claim 15,
The interfacial precipitation method may include preparing a dispersed phase in which a fat-soluble active material stabilization solution is uniformly mixed with a solution in which the polymer polymer is dissolved; Dissolving the surfactant in water to prepare a continuous phase; Preparing an emulsion by adding the dispersed phase to the continuous phase; And Method for producing a cosmetic composition comprising the step of preparing the polymer capsules by drying the emulsion. The method of claim 15,
The oil-soluble active substance stabilizing solution is a cosmetic composition, characterized in that containing from 0.1 to 100 parts by weight of the fat-soluble active substance, based on 100 parts by weight of the oil. The method of claim 18,
Wherein the stabilizing solution of the oil-soluble active substance comprises 0.1 to 100 parts by weight of any one or more of the antioxidant, the ultraviolet screening agent and the skin irritation alleviating agent, based on 100 parts by weight of the oil. The method of claim 15,
The content of the fat-soluble active substance stabilization solution relative to 100 parts by weight of the polymer capsule is 0.1 to 95 parts by weight cosmetic composition. The method of claim 15,
The amount of the flowable gel layer based on 100 parts by weight of the polymer haptic capsule is 10 to 500 parts by weight of the cosmetic composition.

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