KR20130060684A

KR20130060684A - A lipolysis kit

Info

Publication number: KR20130060684A
Application number: KR1020110126881A
Authority: KR
Inventors: 권민정; 고현주; 박선영; 박원석
Original assignee: (주)아모레퍼시픽
Priority date: 2011-11-30
Filing date: 2011-11-30
Publication date: 2013-06-10

Abstract

The present invention relates to a kit comprising an injection solution containing a low frequency stimulator and a lipolysis means, and a device and lipolysis that have an excellent effect in alleviating pain, bruising, erythema, edema, hardening, and itching caused by lipolysis injection. To a combination of injections.

Description

Lipolysis kit {A lipolysis kit}

The present invention relates to a lipolysis kit that has an excellent effect on alleviating pain, bruising, erythema, edema, swelling, itching, and the like, from which lipolysis injections are derived.

Lipolysis is the breakdown of triglycerides contained in fat cells and is caused by the action of hormone-sensitive lipases and is controlled by hormones or autonomic nerves. Recently, lipolysis injection using lipolysis is gaining popularity as one of methods for weight loss or body management that is easier than exercise or diet.

Lipolysis injection can remove and remove fat in the desired area, but there are side effects such as pain, bruising, erythema, swelling, sclerosis, and itching after the procedure, and there have been difficulties in returning to normal life after the procedure.

Republic of Korea Patent Application No. 2007-7020672

The present inventors are to provide a lipolysis kit having excellent lipolysis effect while reducing the side effects as described above.

In order to achieve the above object, the present invention is a low frequency that has an excellent effect in relieving pain, bruising, erythema, swelling, itching, etc. caused by lipolysis injection by relaxing and contracting muscles to exercise and blood circulation effect A kit is provided in which a stimulator and a lipolysis means are combined together.

According to the low frequency stimulator kit according to an embodiment of the present invention, a lipolysis injection such as pain, bruising, erythema, swelling, sclerosis, itching, etc., which are usually shown at the injection site by lipolytic action after lipolysis injection by low frequency stimulation, You can minimize specific side effects.

1 is a circumferential graph for comparing the edema reduction effect of PPC injection and PPC injection + low frequency stimulator.
2 is a colorimeter measurement graph for comparing the bruising effect of PPC injection and PPC injection + low frequency stimulator.
3 is a photograph for comparing the bruise reduction effect of PPC injection and PPC injection + low frequency stimulator.
4 is a graph of a subject questionnaire for comparing the pain reduction effect of PPC injection and PPC injection + low frequency stimulator.
5 is a photograph for comparing the effect of bruising, edema, erythema of PPC injection and PPC injection + low frequency stimulator.

The lipolysis kit according to an embodiment of the present invention may include a lipolysis means including a composition for lipolysis, a delivery mechanism capable of delivering the same to a target position to decompose fat, and a muscle stimulator due to low frequency generation.

Lipolysis means included in the kit according to an embodiment of the present invention may deliver the active ingredient to a target site such as, for example, a fat decomposition composition including an active ingredient for lipolysis, and accumulation or sagging skin of fat. And a delivery mechanism, such as a syringe having one needle, a syringe having a plurality of needles, a patch, a micro needle, and the like.

The lipolytic active ingredient is a component for reducing fat at the target site, and may contain, for example, at least one of lipids, bile acids or salts thereof, beta adrenergic receptor agonists and hyaluronidase, and more specifically, Deoxycholine acid, choline acid, chenodeoxycholine acid, 7-alpha-dehydroxylate chenodeoxycholine acid, lithocholine acid, ursodeoxycholine acid, dihydroxytaurine acid, trihydroxytaurine acid and And salts thereof, phosphatidylcholine, hyaluronidase, aminophylline, theophylline, isoproterenol, salbutamol and salmeterol and salts thereof.

The active ingredient for lipolysis as described above is excellent in fat dissolving effect, cellulite removal, skin elasticity regenerating effect and relatively reliably destroys the fat layer of the local area without cumbersome procedures, and breaks the binding of fat cells and makes fat Destroys it in a liquid state and discharges it through the lymph circulation to urine.

A lipolytic composition comprising such a lipolytic active ingredient may be delivered to a target site to which fat is to be decomposed via, for example, a syringe having one needle or a plurality of needles, for example a patch or the like. It may be attached to the target site in the form of and delivered to the target site, for example, may be delivered to the target site using a microneedle, but is not particularly limited thereto.

Low frequency stimulator included in the kit according to an embodiment of the present invention refers to a mechanism for transmitting a stimulus to the human body by generating a vibration or wave of a low frequency, for example 1Hz ~ 5000Hz. When the active ingredient for lipolysis as described above is delivered to the target site to decompose fat, side effects such as erythema, pain, bruising, erythema, edema, hardening and itching occur, and the low frequency stimulator as described above is targeted. When applied to deliver the stimulation, it can reduce the side effects as described above. When the low frequency stimulator is applied to the target site, the body and blood vessels may be appropriately stimulated to decompose body fat of the site, thereby having a synergistic effect on weight loss and reducing side effects.

Thus, by providing a kit comprising a lipolysis means and a low frequency stimulator according to an embodiment of the present invention, pain, bruising, erythema, edema, stiffness, which are side effects that are commonly seen on the target site by the lipolytic action of the lipolytic composition It can relieve symptoms such as itching, and it can facilitate the return to daily life after the procedure.

Hereinafter, the present invention will be described more specifically with reference to examples and test examples. These examples are provided only for understanding the contents of the present invention, but the scope of the present invention is not limited to these examples and test examples, and modifications, substitutions, and insertions commonly known in the art may be performed. It may be included in the scope of the present invention.

Test Example 1 Comparative Test of Edema Reduction Effect by PPC Injection

The subjects were divided into two groups, and one group used only a PPC injection (Phosphatidyl Choline (manufactured by Pacific Pharmaceuticals)) in the left upper arm and a kit consisting of PPC injection and a low frequency stimulator (Slenderton) in the right upper arm. The other group used a kit consisting of a PPC injection and a low frequency stimulator on the left and only a PPC injection on the right.

At this time, the amount of PPC used per arm was 10ml, using a low frequency range of 4 to 99Hz, was performed once every 20 minutes.

The circumference measurement site was marked on both upper arms of the subjects before the start of the test, and the circumference of the arm was measured. The difference between the humeral circumference of the 1st, 2nd and 3rd day after injection showing edema is Δ upper arm circumference, and the injection of PPC injection only and the group using the kit consisting of PPC injection and low frequency stimulator After comparing the values, the results are shown in FIG. 1.

As a result of the test, the arm arm circumference of the subject's arm was reduced by 50% compared to the case of injecting only PPC injection. there was.

Test Example 2 Comparative Test of Bruising Reduction by PPC Injection

It tested in the same manner as in Test Example 1. In order to quantify and compare the bruise reduction effect, the subject area was measured using a color difference meter. L-values, a-values, and b-values that appear in the chrominometer are for displaying three characteristics of color: brightness, saturation, and color. L-value indicates brightness, the higher the a-value, the closer to red color, and the lower the closer to green. If the b-value is high, it is yellow, and if it is low, it is blue. The difference between the measured values on the first day after injection where the bruise was the highest was expressed as Δ and compared with the ΔL-value, Δa-value, and Δb-value, respectively. Since most of the subjects had bruises closer to red erythema than blue bruises, a-value comparison was given priority. The test results are shown in FIGS. 2 and 3.

As shown in FIG. 2, the use of a kit consisting of the PPC injection and the low frequency stimulator of the present invention significantly reduces the degree of bruising such as about 19% in lightness and about 30% in saturation than when only PPC injection is used. I could see. In addition, as can be seen in the photo of Figure 3, when using the kit of the present invention it was confirmed that the degree of bruise close to the erythema is remarkably improved as can be seen by the eye.

Test Example 3 Comparison of Pain Reduction Effect by PPC Injection

It tested in the same manner as in Test Example 1. Subject questionnaire was performed on day 1, day 2, day 3 and day 8 after injection to quantify the degree of pain. The higher the pain, the closer to 5, the results are shown in FIG.

As shown in Figure 4, when using the kit consisting of the PPC injection and low frequency stimulator of the present invention, the pain was reduced by more than 50% than the first day on the second day of the test has a pain improvement effect about 13% faster than using only PPC injection Could know.

Test Example 4 Comparative test of bruising, edema, erythema reduction effect by PPC injection

It tested in the same manner as in Test Example 1. When comparing the 8th day post-injection photograph, the arm of the PPC-only injection and the arm using the kit consisting of the PPC injection and the low frequency muscle stimulator were compared with the photograph, and the degree of swelling and the degree of swelling were shown in FIG. 5.

As can be seen in the photo of Figure 5, when using the kit of the present invention than the case of using only PPC injection, it was found that the overall side effects of lipolysis injections such as bruising, edema, erythema improved visually discernible.

Claims

Lipolysis means comprising a composition for lipolysis, a delivery mechanism for delivering the lipolysis composition to a target site; And
Lipolysis kit with reduced side effects, including low frequency stimulator.

The method of claim 1,
The lipolysis composition is a lipolysis kit comprising at least one of lipids, bile acids or salts thereof, beta adrenergic receptor agonists and hyaluronidase.

3. The method according to claim 1 or 2,
The lipolytic composition is deoxycholine acid, choline acid, chenodeoxycholine acid, 7-alpha-dehydroxylate chenodeoxycholine acid, lithocholine acid, ursodeoxycholine acid, dihydroxytaurine acid, trihydric acid Lipolytic acid and its salt, phosphatidylcholine, hyaluronidase, aminophylline, theophylline, isoproterenol, salbutamol and salmeterol and a lipolysis kit comprising at least one thereof.

The method of claim 1,
Wherein said delivery mechanism comprises at least one of a syringe comprising one needle, a syringe comprising a plurality of needles, a patch and a micro needle.

The method of claim 1,
The low frequency stimulator is a lipolysis kit that allows the muscle of the injection site to relax or contract by the generation of low frequency.

The method of claim 1,
The side effect is a lipolysis kit that is a symptom comprising at least one of pain, bruising, erythema, edema, sclerosis and itching.