KR20120124975A - Food composition containing the extract of Plantago asiatica L. for showing the antioxidative activities and improving the metabolism of the lipid - Google Patents
Food composition containing the extract of Plantago asiatica L. for showing the antioxidative activities and improving the metabolism of the lipid Download PDFInfo
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- KR20120124975A KR20120124975A KR1020110042948A KR20110042948A KR20120124975A KR 20120124975 A KR20120124975 A KR 20120124975A KR 1020110042948 A KR1020110042948 A KR 1020110042948A KR 20110042948 A KR20110042948 A KR 20110042948A KR 20120124975 A KR20120124975 A KR 20120124975A
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- extract
- plantain
- food composition
- plantago asiatica
- antioxidant
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
- A23L29/37—Sugar alcohols
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/302—Foods, ingredients or supplements having a functional effect on health having a modulating effect on age
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/32—Foods, ingredients or supplements having a functional effect on health having an effect on the health of the digestive tract
Abstract
Description
The invention plantain (Plantago Asiatica L.) relates to a food composition containing the extract as an active ingredient, and more particularly to a food composition with excellent antioxidant and lipid metabolism improving effect.
In recent years, the mortality rate of circulatory diseases caused by hyperlipidemia is increasing due to dietary changes due to westernization (Kim, JD, Lee, YI, Kim, BR, Choi, YS and Lee SY. (1997) Effects of meju powder supplementation on lipid metabolism in rats fFed hypercholesterolemic diet.J. Korean Soc.Food Sci.Nutr., 26, 314-318), is experiencing a rapid increase in the development of chronic degenerative diseases. In particular, the incidence of vascular circulation diseases such as atherosclerosis, myocardial infarction, and hypertension due to excessive intake of animal fat is increasing rapidly (Kim, BR, Kim, JD, Ham, SS). , Choi, YS and Lee, SY (1995) Effects of spice added natto supplementation on the lipid metabolism in rats.J. Korean Soc.Food Sci.Nutr., 24, 121-126, Sung, IS, Kim, MJ and Cho , SY (1997) Effect of Quercus acutissima carruthers extracts on the lipid metabolism. J. Korean Soc. Food Sci. Nutr., 26, 327-333). Over the past decades, studies have shown that the total amount and quality of fats consumed by daily diet is closely related to the development or prevention of chronic diseases (Yu, CH (2007) A study on the fat and fatty acid intake of college women evaluated through internet nutritional assessment system.Korean J. Nutr., 40,78-88; Whitney, EN and Rolfes, SR (2002) Understanding nutrition, 9th de., Wadsworth / Thomson Learning, CA , USA .; Bowman, BA and Russell, RM (2001) Presents knowledge in nutrition, 8th., ILSL, Washington DC, USA .; Yu, CH (2002) A review on the changes of lifestyle and the related nutritional problems in Korea Korean J. Nutr., 5, 137-146; Kang, JH (1998) Current status and perspectives of nutritional assessment in periodic health examination.Kor. J. Community Nutr., 3, 855-858; Moon, SJ, Sohn. , CY, Kim, JH, Kim, HS, Li, HS, Lee, HC, and Huh, KB (1994) Measurement of nutrition counseling effects for diabetes mellitus pa Tients.Korean J. Nutr., 27, 1070-1077; Nestle, M. (1998) Nutrition in medical education-New policies needed for the 1990 S. J. Nutr. Educ., 20, 1-6).
On the other hand, in recent years, the desire for well-being has increased so much that the interest in proper fat intake has increased. However, the Ministry of Health and Welfare. 2005. 2006. National health and nutrition Examination survey report.) Per capita fat intake per person increased from 29.5 g in 1985 to 46.0 g in 2005, 20 years later, and a number of chronic degenerative geriatric diseases have emerged as a serious social problem. .
One of the causes of chronic degenerative diseases is oxidative stress, which is elevated by the increase of free radicals in the body and has been reported to be related to the progression of various diseases such as aging, diabetes, hypertension and cancer (Baynes, JW ( 1991) Role of oxidative stress in development of complications in diabetes.Diabetes 40, 405-12). As the production of free radicals increases, the nutritional status of antioxidants in the body decreases, which leads to an increase in oxidative stress, a decrease in the activity of the antioxidant system, and the formation of free radicals to attack biofilm lipids in association with the induction of chronic degenerative diseases. As a result, lipid peroxides accumulate in the living body, causing damage and metabolic disorders in tissues, causing various diseases. These results increase the need for antioxidants in the body with degenerative diseases (Plaa, GL and Witschi, H. (1976) Chemacals, drugs and lipid peroxidation. Annu. Rev. Pharmacol. Toxical., 16, 125-131; Alordmann, R., Ribierre, C. and Rouach, H. (1990) Ethanol induced lipid peroxidation and oxidative stress in extrahepatic tissues.Alcohol , 25, 231-237 .; Cha, JY, Kim, HJ and Cho, YS (2000 ) Effects of Water-Soluble Extract from Leaves of Morus alba and Cudrania tricuspidata on the Lipid Peroxidation in Tissues of Rats.J. Korean Soc.Food Sci.Nutr., 29, 531-536). Antioxidant nutrients from diet and other factors in the body's antioxidant system need to play a role in preventing oxidative damage from degenerative diseases (Kim, JH, Kim, MJ and Kwak, HK (2006) Obesity Indices and Plasma Total Antioxidant Status in Hypertensive Elderly Living In Ulsan Area Korean J. Communl'ry rurrf'rion, 11, 279-288).
Recently, active oxygen is known to cause aging and geriatric diseases, and research on the development of antioxidants that can control free radicals has been actively conducted, and natural antioxidants such as SOD (superoxide dismutase), catalase, glutathione peroxidase, etc. Jane tocopherol, vitamin C, carotenoid, catechin, glutathione and other synthetic antioxidants such as BHA, BHT and Troxol-C have been reported (Hatano, T. (1995) Constituents of natural medicines with scavenging effects on active oxygen species-Tannins and related polyphenols.Natural Medicines, 49, 357-363; Kitahara, K., Matsumoto, Y., Ueda, H. and Ueoka, R. (1992) A remarkable antioxidant effect of natural phenol derivatives on the autoxidation of-irradiated methyl linoleate Chem. Pharm. Bull., 40, 2208-2209; Cha, BC and Lee, SB (2000) Constituents of Antioxidative Activity and Free Radical Scavenging Effect from Galla Rhois ( Rhus javanica Linne). Kor. J. Pharmacogn., 31, 185-189; Masaki, H., Sakaki, S., Atsumi, T. and Sakurai, H. (1995) Active-Oxygen scavenging activity of plant extracts. Bul. Pharm., 18, 162-166). In addition, various antioxidant vitamins in natural products, such as vitamin E, vitamin C and carotene, act not only to prevent rancidity of fats and oils in food, but also to prevent physiological functions such as anti-cancer, prevention of coronary artery disease and prevention of cataract in the human body. (Block, G. and Langseth, L. (1994) Antioxidant vitamins anddd disease prevention.Food Technology, 48, 80 .; Shin, DH (1997) FUNCTIONAL FOOD.Food Sci. And Industry, 30, 14-21).
On the other hand, while lipids are essential nutrients that supply essential fatty acids and are efficient sources of energy storage in the body, they cause various chronic diseases, such as atherosclerosis and cardiovascular diseases, depending on the excess intake and constituent fatty acid ratio. Influences of triglycerides, phospholipids, cholesterol contents and blood lipoprotein concentrations in blood lipids are known to have a significant effect on the induction of heart disease and atherosclerosis (Park, KS (2006) Metabolic Syndrome.Korean Diabetes Association, 7, 37-44).
In particular, the results of epidemiological studies based on qualitative content as well as quantitative problems of fat show that the incidence of cardiovascular disease is correlated more with the intake of fat, and the type of fats and fats consumed has a great effect. (Emst, JS, Alice, HL, Stetania, IF, Judith, RM and Jose, MO (1995) Lipoprotein, nutrition, aging and atherosclerosis. Am. J. Clin. Nutr., 61, 726-730.).
Since the 1970s, circulatory diseases, including hypertension, stroke, and atherosclerosis, have become the second most important cause of death in Korea after cancer, and have rapidly changed to a similar pattern to that of developed countries. The number of boats increased, accounting for about 30% of all deaths (Kang, HK, No, JK, Sung, DY, Kim, ND, Lee, KH, Kim, KW, Choi, WC, Yim, UK, Yoo, BP). and Jung, HY (1997) Effects of aging and dietary restriction on free radical generation and GSH / GSSG level in rat testis.The Journal of Gerontology 7: 92-97.).
Plantain (Plantago asiatica L.) is a perennial herbaceous plant belonging to the Plantagoginaceae, whose leaves are oval or ovate, with white flowers in June to August, and 6 to 8 melanoma fruits in October. . It is a naturalized plant that grows naturally in the mountains, roads, and buildings around Korea. It is often grown in the wheel of a wagon, and is called Chajeoncho. In oriental medicine, it is called Chajeoncho, Daechajeon, Chapicho, Yaji. It is called vegetables, hippopotamus, giljanggu, compound clams, beetle and vagina, and since ancient times, leaves and stems have been mixed with herbs or meat and eaten with red pepper paste (Jeong, CH, Bae, YI, Shim, KH and Choi). , JS (2004) DPPH radical scavenging effect and antimicrobial activeities of Plantain ( Plantago asiatica L.) extracts. J. Korean Soc. Food Sci. Nutri., 33, 1601-1605).
The plantain, which is a wild plant that grows in Yasan, is divided into Chajeoncho and Chajeoncho in oriental medicine. Especially, Chajeoncho is a bleeding blood, strong heart, gonorrhea, and Taedok ( 해독), reported to be effective in antidetoxification of carbuncles, gynecological diseases, pleurisy, and constipation caused by egg, heart disease and heat poisoning (Lee, SJ (1996) .Korean folk medicine.Publishing center of Seoul National University, Seoul. P 130), and the planar seed, Cha, has been used as a folk remedy for its anti-inflammatory and diuretic effects (Lee Sun-Woo, Yong-Joo Lee (1971). (p. 267), Shin Gil-gu (1973), Theory of Theory of the Primary, Hydrologic History, Seoul, p. 347). In addition, plantains of the plantain include iridoid glycosides such as genipiosidic acid, aucubin and flavone glycosides such as acetoside, plantagoside, plataginin, honoplantagin, ursolic acid, and other β-sitosterol, choline, palmitic acid, stigmasterol, vitamin B 13 and vitamin C. (Park, CH (1996) A taxonomic and systematic study of genus plantago in Korea.MS Thesis.Korea University; Chang Sang Moon, Choi Jung, Kim Jong Wan, Park, Byung-Yun, Park, Sun-Dong (1996) Herbal Resources Botany, Academic Publishing, Seoul, p 374-376).
Recently, pharmacological studies from plantain (Ko, ST and Lim. DY (1977) Phamacological studies of Plantaginis Semen. J. Korean Pharm. Sci., 7, 28-37), isolation of the iridoid glycoside aucubin (Yun, HS, Chang IM Choi, HJ and Lee, SY (1980) Plants with liver protective activities (); Chemistry and pharmacology of Plantaginis Semen meat Folium . Kor. J. Pharmacog., 11, 57-60), Chang, IM (1998) Liver-protective activities of aucubin derived from traditional oritental medicine.Res.Commun.Mol.Pathol.Pharmacol., 102, 189 (204), prevention and treatment effects for various chronic degenerative diseases (Davidson, MH, Maki, KC, Kong JC, Dugan LD, SA, Hall, HA, Drennan, KB, Aderson, SM, Fulgoni, VL, Saldanha, LG and Olson, BH (1998) Long-term effects of consuming foods containing psyllium seed husk on serum lipids in subjects with hypercholesterolmia.Am J. Clin.Nutr., 67, 367-376; Anderson, JW, allgood, LD, Turner, J., Oeltgen, PR and Daggi, BP (1999) Effects of psyllium on glucose and serum lipid responses in men eith type 2 diabetes and hypercholesterolmia.Am. J. Clin. Nutr., 71, 1433-1438). Various studies are being actively conducted.
On the other hand, recently, many food materials using natural products have been developed to reduce human body irritation caused by various chemicals. Natural materials have less side effects on the human body, and as the consumer's response to the processed food products using natural materials has increased recently, the development value of natural materials is increasing.
Accordingly, the inventors of the present invention have studied the natural products having high antioxidant capacity and lipid metabolism improving effect, and have completed the present invention which can utilize plantain as such a functional food material.
The present invention can be added to various foods, and an object of the present invention is made of natural extracts, which is harmless to humans and provides excellent safety food composition.
In addition, it is an object of the present invention to provide a food composition that reduces the amount of free radicals produced in the blood and is very excellent in antioxidant effects.
In addition, an object of the present invention is to provide a food composition that can effectively reduce lipid metabolism by reducing serum cholesterol content, triglyceride content, and increasing the content ratio of HDL-cholesterol to total cholesterol.
In addition, an object of the present invention is to provide a food composition capable of improving and preventing various geriatric diseases, adult disease diseases, arteriosclerosis and cardiovascular diseases.
In order to achieve the above object, the present invention plantain (Plantago Asiatica L.) It is characterized by containing an antioxidant food composition as an active ingredient.
The invention also plantain (Plantago asiatica L.) It is characterized by a food composition for improving lipid metabolism containing the extract as an active ingredient.
In addition, the present invention is characterized in that the plantain extract is a powder.
Hereinafter, the means for solving the problems of the present invention will be described in detail.
The present invention relates to a food composition, and more particularly to a functional food excellent in antioxidant and lipid metabolism improving effect.
Food compositions of the present invention plantain (Plantago Asiatica L.) extract contains an excellent antioxidant as an active ingredient. Specifically, the present invention is effective in reducing the amount of free radicals in the blood as an antioxidant, which is effective in various adult diseases such as aging, diabetes, hypertension, and cancer.
In addition, the food composition of the present invention plantain (Plantago Asiatica L.) extract as an active ingredient has an excellent lipid metabolism improvement effect. Specifically, the present invention reduces the total cholesterol content and triglyceride content in the serum, increases the content ratio of HDL-cholesterol to the total cholesterol, and has an excellent effect on arteriosclerosis or cardiovascular disease.
Unlike other lipoproteins, HDL-cholesterol is a beneficial lipoprotein that reduces the risk of cardiovascular disease.It increases the proportion of HDL-cholesterol in total cholesterol, which can prevent various arteriosclerosis including coronary atherosclerosis as well as inhibiting hyperlipidemia. Blair, SN, Kohl, HW and Paffenbarger, RS (1989) Physical fitness and all cause mortality: A prospective study of healthy men and women.JAMA , 262, 2395-2401. In addition, the ratio of HDL-cholesterol to total cholesterol is important because LDL-cholesterol, total cholesterol, and triglycerides are positively correlated with coronary heart disease caused by atherosclerosis, whereas HDL-cholesterol is a disease of coronary heart disease. (Smutok, MA and Reece, C. (1993) Aerobi versus strength training for risk factor intervention in middle aged men at high risk for coronary heart disease. Metabolism, 42, 177-). 184).
In addition, serum triglycerides have been reported to have a direct relationship with the development of stroke because they pass well through vascular endothelial cells (Felman, RG and Albrink, MJ (1964) Serum lipids and cerebrovascular disease. Arch. Neuro., 10, 91- 92). In addition, triglycerides, which serve as energy storage sources, are mostly synthesized in adipose tissue and liver and are sensitive to high calorie intake and energy consumption. In particular, the level of triglycerides is known to be a very important indicator for the determination of hyperlipidemia, and in obese people, the decrease in triglyceride content is important for the prevention of cardiovascular diseases (Sohn, IS ( 1975) Studies on the hypercholesteroemia of Koreaans.Kor. J. Med., 18, 354-357).
In addition, the plantain extract of the present invention can be obtained through a variety of methods known in the art, the extraction solvent is preferably purified water, methanol, ethanol, glycerin, ethyl acetate, butylene glycol, propylene glycol, dichloromethane, hexane and Those selected from mixtures thereof can be used.
In addition, the plantain extract of the present invention includes not only the aforementioned extraction method, but also extracts extracted by other methods. Separation using, for example, an ultrafiltration membrane having a constant molecular weight cut-off value; Various chromatography, for example separation by chromatography prepared for separation according to size, charge, hydrophobicity or affinity; In addition, the fraction obtained through various purification methods carried out is also included in the plantain extract of the present invention.
In addition, the plantain which becomes a material of extraction in this invention can be used by drying it, or it can be used as it is, Preferably it is used by drying. As a drying method, natural drying, shade drying, or a hot air drying method can be used. In addition, plantain may be used by grinding the plantain in order to facilitate extraction.
In addition, the plantain extract of the present invention can be used in a liquid state, it is preferable to prepare and use in powder form by an additional process such as distillation under reduced pressure, freeze drying or spray drying.
For example, the plantain extract of the present invention is put into a triangular flask and added 9 times distilled water and extracted twice in 12 hours using a reflux condenser, and the extract is filtered with cotton cloth and concentrated under reduced pressure (CCA-1100). , Eyela, Tokyo, Japan), and it is preferable to prepare in a powder state through rapid freeze drying (PVTFA 10AT, Ilsin Co., Youngju, Korea) at -70 ℃.
In addition, the food composition containing the plantain extract of the present invention as an active ingredient may be added to various foods in an amount of 1 to 100% by weight for the purpose of enhancing antioxidant or lipid metabolism improvement. Food composition of the present invention can be added to various foods for the development of dietary supplements, for example, various foods, meat, beverages, chocolate, snacks, snacks, pizza, ramen, other noodles, gum, ice cream, Alcoholic beverages, vitamin complexes, and health supplements.
In addition, the food composition according to the present invention may contain, in addition to the above plantain extract, other ingredients that can give a synergistic effect to the main effect, preferably within the range of not impairing the main effect of the present invention. .
The present invention can be added to various foods, it can be made of natural extracts to provide a food composition excellent in safety and harmless to the human body.
In addition, the present invention can provide a food composition that reduces the amount of free radicals in the blood and is very excellent in antioxidant effects.
In addition, the present invention can provide a food composition that can effectively reduce lipid metabolism by reducing serum cholesterol content, triglyceride content, and increasing the content ratio of HDL-cholesterol to total cholesterol.
In addition, the present invention can provide a food composition that can improve and prevent various geriatric diseases, adult disease diseases, arteriosclerosis, cardiovascular disease, and the like.
1 is a graph showing the results of measuring the antioxidant power change in the experimental rats fed the experimental diet for 7 weeks in Experimental Example 3.
Figure 2 is a graph showing the results of measuring the change in the amount of active oxygen produced in the experimental rats fed the experimental diet for 7 weeks in Experimental Example 3.
Hereinafter, the present invention will be described in more detail with reference to the following examples, but the scope of the present invention is not limited to the following examples, and includes all modifications of equivalent technical spirit.
Manufacturing example : Preparation of Plantain Extract
Plantain used in this preparation ( Platago asiatica L. ) was grown in 2009 and used in Kum-O-Dang Herbal Medicine of Jeonju, Korea.Planted plantains were put in a Erlenmeyer flask and 9 times distilled water was added and extracted twice with 12 hours using a reflux condenser. After filtering with a cotton cloth and concentrated under reduced pressure (CCA-1100, Eyela, Tokyo, Japan) was prepared in a powder state through rapid freeze drying (PVTFA 10AT, Ilsin Co., Youngju, Korea) at -70 ℃.
Experiment Preparation 1: Assignment of Rats and Dietary Groups
In the present production example plantain extract in Three-week-old Sprague-Dawley (SD) male rats were purchased from Polars International (Seoul, Korea) for in vivo experiments.
Adapted to the environment by pre-breeding with the general feed (Harlan Teklad, Indianapolis, USA) and measuring the antioxidant and free radicals during the pre- breeding period. After sorting, the animals were separated and bred one by one in the stainless cage (MJ Ltd., Seoul, Korea) for 7 weeks in the animal breeding room of the Department of Food and Biotechnology, Kangwon National University.
The temperature in the feeding room was maintained at 23 ± 1 ℃ and the humidity at 50 ± 5%. The lights were turned on (07 to 19 o'clock) and turned off (07:00 and 19:00) every 12 hours. It was. Dietary free benefits during the experiment ( ad libitum ), and the water was ingested with distilled water.
Experiment Preparation 2: Preparation of Dietary Rats
The plantain extract of the present preparation was prepared by mixing as shown in Table 1 according to the dietary composition recommended by the American Institute of Nutrition (AIN). Casein, cellulose, AIN-76 mineral mix, AIN-76 vitamin mix, choline bitatrate, cholesterol, cholesterol, corn starch (corn starch), DL-methionine (DL-methionine) used ICN Biochemicals (MP Biomedical, Ohio, USA) products, corn oil (corn oil), sucrose (sucrose) products from CJ Cheiljedang Co., Seoul, Korea Was used.
Example 1: Investigation of weight gain and dietary intake of rats
In this example, the weights of the mice were measured at regular intervals (5 pm) at weekly intervals, and the diet was removed 2 hours before the measurement to prevent temporary weight changes due to dietary intake. The dietary intake was measured at 9 am every two days, and the intake was calculated by subtracting the remaining amount from the dietary weight provided. In addition, the weight gain of 7 weeks divided by the dietary intake of 7 weeks to calculate the feed efficiency (feed efficiency ratio, FER) is shown in Table 2 below.
According to Table 2, the weight gain was measured after feeding for 7 weeks as an experimental diet, the control group was 180.3 ± 17.8 g and the plantain extract feeding group was slightly higher (184.7 ± 10.3 g). The experimental dietary intake was found to be 572.8 ± 19.7 g in the control group and 668.9 ± 72.4 g in the plantain extract supplemented group, which was slightly higher in the plantain extract supplemented group. In the results of the measurement of dietary efficiency (FER, weight gain divided by dietary intake), the control group was 0.31 ± 0.5 and the plantain extract feeding group was 0.27 ± 0.3, which was slightly higher, but there was no statistical significance. From this, the extract of plantain of the present preparation was judged not to show a significant obstacle to the growth and dietary intake of animals.
Experimental Example 2: Measurement of Organ Weight in Rats
In the present experimental example, after the breeding period was completed for the mice, the head was slaughtered after 12 hours of fasting, blood was collected, left at room temperature for 30 minutes, and centrifuged at 4 to 3,000 rpm for 15 minutes to separate serum supernatant. The liver, heart, spleen and kidneys are extracted immediately after collection of blood, washed with cold saline solution (0.89% NaCl), the blood and water in the tissues are removed using filter paper, weighed, and weighed. %) Was obtained and shown in Table 3 below. Organ and serum samples were stored in cryogenic freezers at -70 ° C.
As shown in Table 3, the heart weight of the control group was 1.7 ± 0.1 g, the plantain extract feeding group was 1.6 ± 0.1 g, the kidney weight was 1.8 ± 0.1 g in the control group, 1.7 ± 0.1 g in the plantain extract feeding group statistics No significant significance was seen. The liver weight was 11.7 ± 1.0 g in the control group and 11.5 ± 1.2 g in the plantain extract feeding group, and the spleen weight was 0.9 ± 0.1 g in the control group and 1.0 ± 0.1 g in the plantain extract feeding group, compared to the control group. Was higher but there was no statistical significance. The weight index (%) of the organ, weight, liver and spleen extracted from each group of animals was not statistically significant when compared with the control group. Could know. The plantain extract of the present preparation was found to have no effect on the growth of the animal.
Example 3 Measurement of Antioxidant and Free Oxygen Levels in Rats
In this example, antioxidant and active oxygen were measured by an active oxygen antioxidant power analyzer (FRAS 4, SEAC Viale Partigiani, Italy). Antioxidant and free radicals were measured before starting the experiment, and control data were obtained. The free radicals were measured by d-ROMs test kit (Diacron International s.r.l., Grosseto, Italy). As a measuring method, blood was collected in a capillary tube by using an auto lancet on a rat tail, and then mixed in a buffer, shaken, and then centrifuged. Active oxygen values were measured after 5 minutes at 37 ° C. after inserting a light absorbing cubic to FRAS 4. Antioxidant measurement was performed using BAP test kit. The method was same as the measurement of free radical, but only serum was extracted after centrifugation.
Figure 1 shows the antioxidant activity values measured after 4 weeks and 7 weeks while breeding for 7 weeks with the above experimental diet, Figure 2 shows the change in free radicals.
According to Figure 1, comparing the antioxidant activity values between the groups before feeding the experimental diet, the control group was 1427.8 ± 180.0 μMol / L, the plantain extract fed group was 1426.8 ± 380.3 μMol / L, but after 4 weeks there was no significant difference The control group was 2234.2 ± 573.8 μMol / L, but the plantain extract supplemented group was 2503.2 ± 298.9 μMol / L, which showed higher antioxidant activity than before the experiment. In addition, the antioxidant activity of the control group was 2480.6 ± 313.8 μMol / L after 7 weeks, and the plantain extract supplemented group was 2773.4 ± 304.8 μMol / L, which showed significantly higher antioxidant activity than the control group.
According to FIG. 2, the control group was 172.5 ± 14.3 U.Carr and the plantain extract feeding group was 173.8 ± 19.7 U.Carr before feeding the experimental diet. Was 265.9 ± 10.8 U.Carr, plantain extract fed group was 240.8 ± 21.1 U.Carr, and after 7 weeks control group was 270.3 ± 14.3 U.Carr, plantain extract fed group was 249.5 ± 13.8 U.Carr. Compared to the control group, the amount of free radicals was found to be low.
From this, it can be seen that the plantain extract of the present preparation increases the antioxidant activity and decreases the amount of active oxygen produced.
Example 4: Measurement of the Effect on Serum Lipids and Blood Glucose
In this example, the rats were fed with experimental diet for 4 weeks, and then totally cholesterol, HDL-cholesterol, triglyceride, phospholipid, and glucose in serum of the rats were collectively used with BT-1000 (Biotechnica Co., Rome, Italy). It was measured by, and the results are shown in Table 4 below.
According to Table 4, as a result of measuring total cholesterol content in serum after feeding for 4 weeks as an experimental diet, the control group was 237.4 ± 11.8 mg / dL, and the control group was 215.1 ± 17.3 mg / dL. It can be seen that the decrease compared to.
In addition, as a result of measuring the HDL-cholesterol content in the serum after the completion of the experimental diet, the control group was 61.7 ± 6.4 mg / dL, while the plantain extract fed group was 83.2 ± 3.8 mg / dL 21.5 mg / compared to the control group dL (25.8%) was high.
In addition, the control group of HDL-cholesterol / total cholesterol used as the arteriosclerosis index was 26.0 ± 1.5%, whereas the plantain extract fed group was found to increase significantly to 38.7 ± 0.9%. The intake of plantain extract is expected to have an excellent effect on the prevention of coronary heart disease by increasing the HDL-cholesterol content of the total cholesterol in the serum.
In addition, the triglyceride content of serum increases with the increase of kilomicron and its residues in the blood during high fat intake and increases in hyperlipidemia, arteriosclerosis, diabetes, etc. As a result of measuring the content, the control group was 54.7 ± 3.8 mg / dL, whereas the plantain extract fed group was 47.8 ± 1.9 mg / dL, indicating that the plantain extract fed group decreased. The plantain extract seems to be effective in improving hypertriglyceridemia by reducing serum triglyceride content.
In addition, as a result of measuring the phospholipid content that forms a cell membrane and plays an important role in neurotransmission as a complex lipid having phosphate ester in the molecule, the control group was 152.8 ± 27.1 mg / dL, whereas the control group was 160.3 ± 18.5 mg / dL, the plantain extract fed group showed higher values than the control group.
In addition, as a result of measuring the glucose content in the serum, the control group was found to be 153.2 ± 11.8 mg / dL and the plantain extract group was found to be 154.2 ± 16.9 mg / dL showed no significant difference.
In the experimental example of the present invention, the experimental results for each treatment group were presented as mean and standard error (SE) for each measurement variable using SPSS / PC + version 10.0. The t-test was performed and the significance level for all statistical treatments was p <0.05.
Claims (4)
The plantain extract is antioxidant food composition, characterized in that the powder.
The plantain extract is a food composition for improving lipid metabolism, characterized in that the powder.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101588004B1 (en) * | 2015-05-22 | 2016-01-26 | 임종식 | Attractive pill using Great plantain and pockmark cabbage and making method of it |
| KR101888871B1 (en) * | 2018-04-06 | 2018-08-16 | 농업회사법인 주식회사 이비채 | Composition for preventing and treating of obesity or metabolic disease comprising extract from leaf of Plantago asiatica |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101588004B1 (en) * | 2015-05-22 | 2016-01-26 | 임종식 | Attractive pill using Great plantain and pockmark cabbage and making method of it |
| KR101888871B1 (en) * | 2018-04-06 | 2018-08-16 | 농업회사법인 주식회사 이비채 | Composition for preventing and treating of obesity or metabolic disease comprising extract from leaf of Plantago asiatica |
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