KR20120116113A - Composition for strengthening cartilage and muscle using medicinal herbs and seonokgyun and manufacturing method thereof - Google Patents

Abstract

PURPOSE: A composition for strengthening cartilage and muscles using herbal medicine and Sunok bacteria and a manufacturing method thereof are provided to massively amplify small amount of active ingredient contained in the herbal medicine. CONSTITUTION: A manufacturing method of a composition for strengthening cartilage and muscles using herbal medicine and Sunok bacteria comprises the following steps: preparing herbal medicine which includes Cervus cornu parvum, Epimedium jkoreanum Nakai, Aralica elata Seem, tortoise shell, Licorice root, Adlay, Eucommia ulmoides Oliver, Panax notoginseng, Rehmanniae Radix oreoarata, Acanthopanax senticosus Harms, and Eleutherocosis maxim; respectively and separately cultivating lactobacillus, yeast, photosynthetic bacteria + yeast (mixing the photosynthetic bacteria with yeast at the weight ratio of 1:1); manufacturing the Sunok bacteria by re-culturing the mixture in which sugar or molasse is added to the cultivated bacteria; making fermented herbal medicine by mixing and fermenting the prepared herbal medicine and the Sunok bacteria with water and molasse; and mixing dried powder in which each fermented herbal medicine is pulverized at predetermined ratio.

Description

Composition for strengthening cartilage and muscle using medicinal herbs and seonokgyun and manufacturing method

The present invention relates to a composition for cartilage strengthening and fermentation of medicinal herbs and useful microorganisms jade jade (善 玉 菌), and more particularly, antler, sesame beetle, trichophyte herb, ulm, licorice, yulmu, tofu, samchil, sukji sulfur The present invention relates to a composition for strengthening cartilage and muscles of herbal medicines fermented by mixing medicinal herb and jade, including thorny cucumber.

Cartilage is composed of chondrocytes and extracellular matrix, mainly composed of type 2 collagen and floateoglycans, which give elasticity and compression It is a unique organization with characteristics. Depending on the composition of the substrate, it is divided into supernatural bone, elastic cartilage and fibrocartilage. In supernatural bone, the substrate is translucent and at first glance uniform and non-structured, but it contains a complex protein (mucoid) that is juicy (60-80%) and has chondroitin sulfate. Elastic cartilage is easy to bend because the elastic fibers in the substrate (이 介: 연 介: cartilage, ear canal, larynx, etc. belong. Fibrocartilage contains a lot of collagen fibers, intervertebral disc cartilage, interosseous cartilage, articular discs, etc. belong to the fibrocartilage. Cartilage action, as seen in the joint cartilage covering the end of the joint, in addition to the action of preventing friction of the end, such as organs (氣管), the wheels to maintain elasticity, or to give pressure resistance, such as ribs, cartilage joint cartilage And the like.

Joints are composed of cartilage, articular capsule, synovial cord, ligaments, tendons and muscles to allow smooth movement between bones and bones, and absorbs shocks generated by movement. Arthritis is caused by inflammation of the joints due to various causes, and the most common symptom is joint pain.

To date, the etiology of arthritis is not clear, and there is no cure for this disease. However, drugs and surgery to improve the symptoms of arthritis are being performed, these drugs have a certain pharmacological action, but various side effects have been reported. Except for current surgical treatments, pain relief using painkillers or nonsteroidal anti-inflammatory drugs, etc. is not a prescription for fundamental treatment. In addition, side effects such as liver dysfunction, gastrointestinal bleeding, nephrotoxicity, hypertension, and cardiovascular disease may occur when the drug is taken for a long time.

In general, herbal treatment aims at minimizing side effects and sequelae while strengthening and treating cartilage, bones and joints, along with inflammation and pain relief.

Therefore, it is necessary to develop fermented herbal medicines of herbal ingredients that are effective in preventing or treating arthritis by strengthening cartilage and muscles and having low toxicity and side effects.

The present invention combines a good herbal medicine for strengthening cartilage and muscle (deer Antler, Tortoiseshell, Trichophyte herb, Aralia, licorice, Yulmu, Tofu, Samchil, Sukjihwang, thorny gopi) and the effective microorganisms (prehistoric fungi) to increase the stability and immunity, Chinese medicine It is to provide a cartilage strengthening composition of herbal medicines fermented herbal medicines and jade jade bacteria to increase the efficacy of the ingredients to alleviate various pains, to prevent diseases.

Another object of the present invention is to provide a composition and a method of manufacturing the same, which is less toxic and side effects, and can be exposed to herbal medicine without rejection.

Another object of the present invention to provide a composition that can be used as an additive of various foods, medicines and health supplements of the raw material of the herbal ingredients without using chemical additives.

The cartilage and muscle strengthening composition fermenting the herbal medicine and jade jade bacteria according to the present invention for solving the above problems are medicinal herbs including antler, tortoiseshell, ogalpi, trichophyllum, ul, licorice, yulmu, tortilla, samchil, sageji, thorny opi Fermented by mixing.

According to a preferred embodiment of the present invention, jade jade is extracted from traditional fermented foods (kimchi, soy sauce, red pepper paste, doenjang, Cheonggukjang, salted fish, etc.) cultured by lactic acid bacteria 10-70% by weight, yeast 10-70% by weight, naphtha bacteria 10- 70% by weight, 1 to 10% by weight of acetic acid bacteria, 1 to 40% by weight of photosynthetic bacteria + yeast (mixed photosynthetic bacteria and yeast in 1: 1 weight ratio) to 1 to 40% by weight of sugar or molasses The mixture is obtained by culturing at least 40 days at 20 ~ 40 ℃ without supplying the medium.

According to a preferred embodiment of the present invention, the mixture of the herbal medicine and jade jade bacteria ferment for 24 to 50 ℃, 2 to 10 days by mixing water, sugar or molasses in a ratio of 100% by weight, respectively.

According to a preferred embodiment of the present invention, the mixing ratio of the herbal medicine and jade jade is blended with 0.01 to 100% by weight medicinal herbs with respect to 100 wt% of the jade bacteria.

The composition to help the cartilage and muscle strengthening fermentation of herbal medicine and jade, according to the present invention is amplified in a large amount of the active ingredient contained in the herbal medicine by fermenting the herbal medicine, increase the survival rate and activity rate by using fermented microorganisms To increase the efficiency of the extraction of the intestinal microorganisms and the effect of increasing the efficacy of the medicinal herbs through fermentation.

In addition, the absorption effect of food is broken down into a low molecular structure has a high absorption rate and bioavailability in the body and there is no side effect.

In addition, it can be used as a safe food or health supplements in addition to medicines and foods.

Hereinafter, the present invention will be described in detail by way of examples, which should not be construed as limiting the present invention.

Zen jade bacteria in the present invention is a useful microbial group represented by lactic acid bacteria, yeast bacteria and photosynthetic bacteria extracted from traditional fermented foods, because they are extracted from foods and are safe to distinguish from useful microorganisms collected from soil. It is called jade jade (善 玉 菌). The jade bacteria are incubated separately using sugar or molasses as a food source, and then mixed according to the purpose of use, and used as conjugate bacteria.

Look at the properties and efficacy of medicinal herbs, including deer antler, tortoiseshell, trichophyte vinegar, ulm, licorice, yulmu, toechung, samchil, sagejiku, thorny ogapi used in the present invention.

Deer Antler ( Cervus cornu parvum ) is a young horn of plum, or mango, and hairy and non-osteolyzed hair of the same species. The pharmacologically active ingredients are ganglioside, amino acids, calcium phosphate, calcium carbonate, collagen, phospholipids, chondroitin, glucosamine, and hyaluronic acid. . Deer Antler has blood pressure lowering, hematopoietic function, hypercholesterolemia, anti-stress effect, and its effect is weaker than single-component medicines, but it is characterized by complex effects throughout the body. The fermented deer antler contained a lot of bioactive substances such as uronic acid and sialic acid, and the activity of yellow complement and radical scavenging are enhanced. Therefore, new activity can be expressed like anti-complement activity besides physiological activity such as hematopoietic activity itself.

 A tortoiseshell is a shell of Zaraaceae. The medicinal herb is oval or elliptical bone fragment, and the back is prominent. There is an inconspicuous fracture at the center, and 8 sides of bilateral symmetry of bilateral symmetry on each side. Its back is gray brown and its belly is gray white. Efficacy of synergism is as follows: Boeum, Sanji, Hagi, Haesoksik, Consonant yangyang, Fever, Fever Osteoporosis (勞 熱 骨蒸) is an animal, but also contains a large amount of unsaturated fatty acids that are the same as vegetable fats, and many essential fatty acids that are not synthesized in the body. In particular, linoleic acid, EPA, and DHA, which have important physiological effects on the human body, prevent blood vessel deposition of cholesterol and prevent atherosclerosis and stroke. It contains calcium and chondroitin, and calcium stabilizes nerves by increasing blood pressure and increasing myocardial contractility. Chondroitin is present in small amounts in the joints, cartilage, skin, and blood vessels of the human body. It is known to be effective in anti-aging, preventing liver disease, preventing skin disease, preventing heart disease, and strengthening joints.

 Epimedium koreanum Nakai (Depisodium koreanum Nakai) dried the former wife called yangyanggwa (淫羊藿) has been used in the herbal medicine such as tonic, gangjeong, foam, diuretic, yin and so on. Dried stalks are hollow with a long, cylindrical shape. Its main ingredient is icariin, which is found in the leaves and stems. In addition to icariin, the leaves contain voatile ails, ceryl alcihol, hentriacontane, phytosterol, tannin, and oils. The pharmacological effect is gangwi, ripening, shoulder blade, gongpoong dehumidification, Boshinyangyang, Chayangyangjeong, and it is not possible to cure the main disease. (陽 委 不 擧), customs pain (風濕 痺 通), urine strength (小 便 林 歷) is used.

Aralica elata Seem is a plant belonging to the family Arboraceae, and has been used in folk medicine and traditional medicine as a diabetic, kidney disease, acute hepatitis, gastrointestinal disease improvement and tonic. Young leaves and stems have a characteristic aroma and bitter taste. As a favorite food, new food branches of edible wild plants are recognized. The active ingredients include triterpenoid, saponin, oleanolic acid, sitosterol, choline, hederagenin, cilgmuyanosides A, C, D, echinocystic acid, alkaloid, palmitic acid, linoleic acid, methyl eicosanoate, 3,4-dithydroxybenzoic acid and hexacosol. . Efficacy is bogiansin (강 安神), Kangjeong self-confidence (거 精 滋腎), gongpung vigor blood (祛風 活血) weak energy, and weakness and nervous arthritis in arthritis, pain and anti-inflammatory effect, renal function weak and yanggi It is effective when there is a lack of strength and sometimes lack of strength and walking disorder. In motion therapy, it is used as a diuretic in addition to diabetes, and as a painkiller, it is used for headache, colic, colitis, and stomach cancer. Licorice (甘草, Glycyrrhiza glabra L.) is pharmacologically associated with corticosteroid activity, anti-inflammatory and anti-allergic action, action on the digestive system, detoxification, effect on lipid metabolism, effect on experimental assignment antitussive action, analgesic and anticonvulsant action, urinary Effects on reproductive system and antitumor activity. Efficacy used for reconciliation of consent includes expectoration, Bobi, Anhon, moderate, salary, lubrication, Ikjeong, tension Efficacy in orthodontics, orthodontic disease, haemorrhoids, clear fever, and lower extremity. It is used in salary, decommissioning, hyeonong, hyeonhun, changdok, Taedok, Hanyeol, seawater, and jungjung.

 Yulmu is a one-year-old herbaceous plant belonging to Gramineae, which is known as Uiin, which has been removed from the fruit peel of Yulmu. It is used in folklore as yukmujuk and yulmucha, and has been used for anti-inflammatory, diuretic and drainage in oriental medicine. Starch, crude protein, fatty oil, copzenolide, coixol, etc. have been reported as components contained in Yulmu, and pharmacological actions have been reported to include analgesic, anticancer and NK cells. In consent agreement, the main disease is jangong (腸 癰), moist rain (濕 痺 拘攣), urinary vulgaris (小 便 不利), non-hybridity (각), several species (편), pyeonwoo, lungs (肺 癰) It is a medicine used.

 Eucommia ulmoides Oliver is a deciduous arborescent tree belonging to the genus Camellia family. The Korean Pharmacopoeia describes many years of bark as a deciduous tree. It is well known for its tonic, soothing and analgesic effects, and has a blood pressure-lowering effect. It is stated that it is used to prevent diseases such as urinary neuralgia, miscarriage and high blood pressure. In addition, the leaves of this plant in Korea drink a lot of tea, and the leaves of the larvae contain more vitamin C than the tea leaves, so long-term activity of the liver and gallbladder is said to be active. Pharmacological activity has the scavenging and antioxidant effects of reactive oxygen species, promoting collagen synthesis, antidiabetic effect based on the mechanism of inhibiting α-glucosidaes, anticancer effect, antimutagenic effect, and anticomplementary activity And the like have been reported. Received lower back pain, hypertension, urine ability, urinary tract, lumbar placebo, pregnancies of pregnancy Used for

Samchil is Panax , an Orchardaceae family It refers to the roots of notoginseng , pharmacological effect is to stop various bleeding, releasing blood, swelling and lowering pain. It is one of the important herbal medicines that are known to treat the symptoms of lack of blood due to the disease, the bleeding of the urine, the swelling of the bruises and fractures, and the swelling and soreness. This plant has been reported to isolate 60 species of saponins. Its effect is to produce hemorrhoids and small orthogonal pains. The main disease of the disease is keratosis, vaginal pain, vomiting and chest pain. It is known to be effective in iii).

Sukjihwang ( Rehmanniae Radix oreoarata) is a herbal medicine processed from the root of perennial herbaceous perennial herbaceous or other related plants, which is used for the purpose of blood, tonic, fever, and sour. The pharmacological effect of this study was to increase the activity of super-oxide dismutase (SOD) in the blood by reducing serum peroxide content in relation to immune regulation, hypoglycemic activity and anti-aging. The effect of Suk-Ji-Hwang on the agreement of Bo-Ji, Yang-Blood, Ikjeong Jeon-Jung, Ja-Bo-Gan-Shin, Yin-Blood Blood It is used in main disease, osteoporosis (골), blood gastric sulphate (血虛 委 黃), yosulsanyeon (腰膝 酸軟) etc. is stated in the agreement.

Acanthopanax senticosus Harms , Eleutherocosis maxim ) is a perennial deciduous shrub belonging to Araliceae, which grows in highlands, and is a dry and cold resistant plant. From ancient times, the roots and stems of the plants of the genus Ogapi are called medicinal to ogapi, and the medicinal efficacy of Ogapi has been recorded in classical Chinese medicine books ranging from Chinese herbal medicine cultivation room, new agricultural plant and herbal herb. Its pharmacological action has been used as a metabolic accelerator for divergence, pouting, etc., and is known as an effective drug for the genitals, tonic, gangjeong, jingyeong, musculoskeletal pain, liver abdominal pain, and muscle pain. It is also known to treat bronchial asthma, increase stamina, increase musculoskeletal activity, anticancer, anti-aging, and the same metabolic activity as ginseng.

The cartilage and muscle strengthening composition fermenting the herbal medicine and jade jade bacteria according to the present invention, fermented by mixing each medicinal herbs and jade fungus, including deer antler, sesame beetle, trichophyte vinegar, gulum, licorice, yulmu, tofu, samchil, sagejiku, thorny scabies . The mixing ratio of the herbal medicine and jade jade is preferably 0.01 to 100% by weight of medicinal herb. At this time, the jade jade for fermentation is an effective microorganism including lactic acid bacteria, yeast, photosynthetic bacteria, naphtha bacteria and acetic acid bacteria extracted from traditional fermented foods such as kimchi, soy sauce, red pepper paste, soybean paste, fermented soybean paste, and salted fish. After mixing, the bacteria are made of the binder.

The herbal medicines described above are fermented according to the fermentation time, and then dried and ground to make powder. 0.1 ~ 15% by weight of deer antler in powder form, 0.1 ~ 10% by weight of Tortoiseshell, 0.1 ~ 20% by weight of Trichophyte herb, 1 ~ 20% by weight of licorice, 1 ~ 20% by weight of licorice, 1 ~ 15% by weight of radish Mix by mixing in the ratio of weight%, samchil 0.1 ~ 15% by weight, 1 ~ 10% by weight of Sukji sulfur, 1 ~ 20% by weight of the stamens to create a composition for cartilage and muscle strengthening.

Hereinafter, the production method of the jade jade and fermented medicinal herbs according to a preferred embodiment of the present invention will be described in detail.

Jade  to make

1. Incubate effective microorganisms, including lactobacillus, yeast, naphtha, acetic acid, and photosynthetic bacteria, extracted from traditional fermented foods, using sugar or molasses as food sources.

2. 20 ~ 70% by weight of lactic acid bacteria, 20-70% by weight of yeast, 10-70% by weight of naphtha bacterium, 1-10% by weight of acetic acid bacteria, photosynthetic bacteria + yeast (mixed photosynthetic bacteria and yeast in a 1: 1 ratio) 1) 40% by weight of mixed jade and sugar in a 1: 1 weight ratio to make a mixture.

3. The mixture is incubated at 20-40 ° C. for at least 40 days without further supply of media to form the jade.

Making fermented herbal medicine pills

Conveniently take the composition for cartilage strengthening into a pill. The ten herbal medicines used in the present invention are different from the fermentation temperature and fermentation period in which the medicinal effects are different, and thus do not mix and ferment each herbal medicine, and then dry and pulverize to obtain powder.

1. Mix 100 liters of water with 100 liters of water and 100 g of jade, and molasses or sugar, 100 g, prepared in Example 1, and ferment for 2-10 days at 24-50 ° C. in a fermentation medicine bath. Preferred mixing ratios of the jade bacteria are lactic acid bacteria 30% by weight, yeast 30% by weight, soybean bacteria 30% by weight, acetic acid bacteria 5% by weight, photosynthetic bacteria + yeast 5% by weight.

2. Each fermented medicinal herb is dried in a dryer at 70-80 ° C. for about 48 hours and then ground to powder.

3. 0.1 ~ 15% by weight of deer antler, 0.1 ~ 10% by weight of Tortoiseshell, 0.1 ~ 20% by weight of trichophyte, 1 ~ 20% by weight of licorice, 1 ~ 20% by weight of licorice, 1 ~ 15% by weight of radish ~ 15% by weight, 0.1-15% by weight of samchil, 1-10% by weight of sucrose sulfur, 1 ~ 20% by weight of the thorny skin compounded to prepare a ring.

Manufacture of cartilage and muscle strengthening rings

10 kinds (Deer Antler, Tortoiseshell, Ogalpi, Trichophyte herb, Dul, Licorice, Yulmu, Toechung, Samchil, Sukjihwang, Gojigapi) Medicinal herbs and jade are combined to ferment the medicinal herb and fermented soybeans .

When jade jade directly combines with herbal medicines, the binding force is lowered, soybean is used as an intermediate compound. The jade is first fermented with soybeans and then with herbs.

Table 1 shows the preferred component ratio of the cartilage strengthening ring using soybean as an intermediate intermediate.

 Herbal medicine  content  weight %  Lactobacillus 7.3 x 10 ⁸ (100mg)  5.0  leaven 5.2 x 10 ⁹ (100mg)  5.0  Photosynthetic bacteria 6.4 x 10 ⁸ (100mg)  5.0 velvet  60mg  3.0 turtle shell  100 mg  5.0 Trilobite vinegar  100 mg  5.0 Thrust  120mg  6.0 licorice  120mg  6.0 Yulmu  120mg  6.0 Tofu  180 mg  9.0 Three  140mg  7.0 Hungjiwang  100 mg  5.0 A goose  200 mg  10.0 Big head  400 mg  20.0

Claims (6)

a) preparing herbal medicines including antler, tortoiseshell, trichophyte vinegar, arbor, licorice, yulmu, soybean curd, samchil, sagejiku, and thorny ogapi;
b) cultivating separately the lactic acid bacteria, yeast, photosynthetic bacteria + yeasts (mixed photosynthetic bacteria and yeasts in a 1: 1 weight ratio), which are traditionally fermented foods kimchi, soy sauce, red pepper paste, doenjang, cheongukjang, salted fish;
c) re-culturing the cultured bacteria and the mixture to which sugar or molasses are added to make jade jade (善 玉 菌);
d) mixing each of the prepared medicinal herbs and jade jade bacteria with water and molasses and fermented to make fermented medicinal herbs; And
e) a method for producing cartilage and muscle strengthening composition, comprising the step of blending each of the fermented medicinal herbs dry pulverized powder in a constant ratio. The method of claim 1, wherein c)
Lactobacillus 10-70% by weight, yeast 10-70% by weight, photosynthetic bacteria + yeast 1-40% by weight of mixed bacteria or molasses in a 1: 1 weight ratio by mixing the mixture at 40 to 40 ℃ without medium supply Method for producing a composition for strengthening cartilage and muscle fermenting herbal medicine and jade jade bacteria, characterized in that obtained by culturing for at least one day. The method of claim 1, wherein step d)
Method of producing a composition for strengthening cartilage and muscle, characterized in that the fermentation for 2 to 10 days at 24 to 50 ℃ by mixing water: jade jade bacteria: herbal medicine: molasses in a ratio of 1: 1: 1: 1. The method of claim 1 or 3, wherein step d)
Method for producing a composition for cartilage and muscle strengthening, characterized in that blending 0.01 to 100% by weight Chinese herbal medicine with respect to 100% by weight of jade. The method of claim 1, wherein step e)
Fermented herbal powder 0.1 ~ 15% by weight, Tortoiseshell 0.1 ~ 10% by weight, 0.1 ~ 20% by weight of trichophyte, 1 ~ 20% by weight, 1-20% by weight of licorice, 1-15% by weight of radish Method for producing a composition for cartilage and muscle strengthening, characterized in that it is blended in a proportion of 15% by weight, 0.1-15% by weight, 1-10% by weight of sucrose and 1-20% by weight. Cartilage and muscle strengthening composition prepared by the method of any one of claims 1 to 5.