KR20120084492A - Oral care composition and toothpaste for improving tooth health - Google Patents

Abstract

PURPOSE: A toothpaste composition and toothpaste using the same are provided to considerably enhance the teeth hardness and recalcification. CONSTITUTION: A toothpaste composition for enhancing dental health contains 0.001-20 wt% of phosphate, 0.001-50 wt% of calcium salt, or a mixture thereof and0.01-15 wt% of gellatin, phosphoserine, or poly-L-lysine.

Description

Oral care composition and toothpaste for improving tooth health}

The present invention relates to toothpaste compositions for tooth health and toothpastes comprising calcium salts and / or phosphates and biocompatible organic materials.

Tooth enamel is a milky, translucent tissue that covers the surface of the crown and protects the dentin, mostly composed of hydroxyapatite (Ca ₁₀ (PO ₄ ) ₆ (OH) ₂ ) and contains a small amount of protein. The enamel is corroded by organic acids produced by decomposing food residues in the dental plaque (hereinafter plaque) attached to the surface of the tooth by anaerobic bacteria S. mutans and S. Soborinus. Decalcification).

_{Ca 10 (PO 4) 6 (} OH) 2 → Ca 2 + + PO 4 3 - + OH -

Tooth decay is known to occur due to such enamel corrosion, that is, demineralization. In order to prevent tooth decay and to strengthen teeth, the following chemical reaction (remineralization) must be performed.

_{^{Ca 2 + + PO 4 3 -}} + OH - → Ca 10 (PO 4) 6 (OH) 2

According to the LeChatlier reaction, which is a principle of parallel movement, demineralization of teeth can be prevented to some extent because saliva contains a small amount of calcium salt and phosphate, but due to the low solubility of hydroxyapatite, Superphosphate was difficult to present, making it difficult to achieve remineralization of teeth. Accordingly, US Patent No. 5,603,922 in the prior art proposed a toothpaste composed of a first component containing calcium salt and a second component containing phosphate in order to implement remineralization of teeth. When brushing with these toothpastes, saliva can cause calcium salts and phosphates, which promotes remineralization of teeth. However, this remineralization of the tooth can fill the enamel of the demineralized tooth, but it is insufficient to increase the hardness of the tooth. Therefore, it is necessary to develop a material that can prevent tooth decay by increasing the hardness of teeth while promoting remineralization of teeth.

The technical problem to be achieved by the present invention is to provide a toothpaste composition which can promote dental remineralization while ultimately improving dental health.

In order to achieve the above technical problem, the present invention is to improve the dental health, characterized in that it comprises one or more mixtures selected from the group consisting of calcium salts, phosphates or mixtures thereof and gelatin, phosphoserine and polylysine It provides a toothpaste composition.

Conventional toothpaste may promote remineralization of the tooth, but there is a problem that is insufficient to increase the hardness of the tooth, the present inventors while trying to study the remineralization of the tooth and the increase of hardness, as well as calcium salt and phosphate enamel When used with calcium salts and / or phosphates, gelatin, phosphoserine, polylysine, or a mixture of two or more of them, a biocompatible organic substance having affinity for the protein of It was confirmed that the hardness of can also be increased to complete the present invention.

Therefore, when the toothpaste composition for promoting dental health of the present invention is used to promote remineralization of teeth and increase the hardness of the tooth, it is possible to increase the effect of preventing tooth decay and ultimately improve dental health.

Phosphate of the present invention is preferably included in 0.001 to 20% by weight relative to the total weight of the toothpaste composition. When the content is less than 0.001% by weight, the remineralization effect of the tooth is inferior, and when it exceeds 20% by weight, discoloration by phosphate may occur, which may be difficult to apply to the formulation.

As the phosphate, sodium monophosphate, sodium diphosphate, sodium triphosphate, potassium monophosphate, potassium diphosphate, potassium triphosphate, iron phosphate or magnesium triphosphate alone may be used or two or more thereof may be mixed. Can be used.

Calcium salt or a mixture of calcium salt and phosphate of the present invention is preferably included in 0.001 to 50% by weight relative to the total weight of the toothpaste composition. If the content is less than 0.001% by weight, the remineralization effect of the tooth is inferior, and if it exceeds 50% by weight, the stability of the formulation may be greatly reduced.

As the calcium salt, hydrous calcium chloride (CaCl ₂ .xH ₂ O), anhydrous calcium chloride (CaCl ₂ ), glycerophosphate, calcium fluoride (CaF ₂ ), calcium citrate, calcium gluconate, calcium oxide, calcium ascorbate, calcium lactate , Monobasic calcium phosphate, dibasic calcium phosphate, tribasic calcium phosphate, calcium carbonate, calcium pantothenate or calcium hydroxide may be used alone or in combination of two or more thereof.

One or two or more mixtures selected from the group consisting of gelatin, phosphoserine, and polylysine, which are biocompatible organic materials of the present invention, is preferably included in an amount of 0.01 to 15% by weight based on the total weight of the toothpaste composition. If the content is less than 0.01% by weight, the synergistic effect of the hardness or impact strength of the tooth is inferior, and if it exceeds 15% by weight, the stability of the formulation may be greatly reduced.

Gelatin is positively charged as can be seen in the following formula (1), not only shows excellent adhesion to the negatively charged teeth, but also can exhibit excellent affinity with a small amount of protein contained in the enamel.

<Formula 1>

Phosphoserine has a phosphate group (H ₂ PO ₄ ) as shown in the following formula 2 can be excellent interaction with phosphate and calcium salts, has an amine group and a carboxyl group and a small amount of protein contained in the enamel It can also show excellent affinity.

 <Formula 2>

Polylysine may have excellent protein affinity with a small amount of protein included in the enamel, as shown in Formula 3 below.

<Formula 3>

In addition, the toothpaste composition of the present invention may further include at least one selected from the group consisting of abrasives, wetting agents, binders, foaming agents, sweeteners, flavoring agents, preservatives, agonists, acidity modifiers and brighteners, in addition to the components described above. have.

As the abrasive, dibasic calcium phosphate, precipitated silica, calcium carbonate, hydrous alumina, kaolin, sodium bicarbonate (NaHCO ₃ ), or the like may be used alone or in combination of two or more thereof. The amount of such abrasives is generally 1 to 60% by weight relative to the total weight of the toothpaste composition.

The humectant is to give stability, sweetness and slight viscosity of the product, and may be used alone or in combination of two or more thereof, such as glycerin, sorbitol solution, amorphous sorbitol solution, propylene glycol, polyethylene glycol, and ziitol. The amount of such humectant is generally 20 to 60% by weight relative to the total weight of the toothpaste composition. Preferably, a mixture of glycerin or amorphous sorbitol liquid and propylene glycol or polyethylene glycol in a ratio of 1: 1 to 10: 1 by weight may be included as the wetting agent in an amount of 20 to 50% by weight based on the total weight of the toothpaste composition. .

As the binder, carrageenan, xanthan gum, carboxy methyl cellulose sodium, carboxy vinyl polymer, sodium alginate, laponite, or the like may be used alone or in combination of two or more thereof. The amount of such binder is generally 0.1 to 3.0% by weight, preferably 0.5 to 2.0% by weight relative to the total weight of the toothpaste composition.

As the foaming agent, anionic surfactants sorbitan fatty acid esters such as sodium lauryl sulfate and sodium lauryl sarcosinate, polyoxyethylene hardened castor oil, polyoxyethylene, polyoxypropylene-based condensed polymer materials, etc. may be used alone or in combination of two or more. It can be mixed and used. The amount of such foaming agent is generally 0.5 to 5.0% by weight, preferably 0.5 to 3.5% by weight relative to the total weight of the toothpaste composition.

The sweetener or flavoring agent is for improving the usability of the product. As such sweeteners, saccharin sodium, aspartame, and licorice may be used alone or in combination of two or more thereof. The amount of the sweetener is generally 0.05 to 0.5% by weight based on the total weight of the toothpaste composition. As such a fragrance, peppermint oil, spearmint oil, menthol, carbon, and the like can be mixed and used in an appropriate amount. Preferably, an anise oil is mixed and used in an appropriate amount thereof.

As said preservative, paraoxy benzoic acid ester, sodium benzoate, methyl paraoxybenzoate, etc. can be used individually, or can mix and use 2 or more types.

The medicament is effective in preventing tooth decay, preventing gum disease and preventing tartar deposition, and can be used as a tooth decay prevention agent such as sodium fluoride, sodium phosphate, talc fluoride, and amine fluoride. , Tranexamic acid, allantoin, capronic acid, enzymes, herbal extracts, etc. may be used, and condensed phosphates, polyphosphates, etc. may be used as anti-tartar deposition preventive agents. It can mix and use 2 or more types.

The acidity adjuster is to adjust the pH of the toothpaste composition, and as such an acidity adjuster, phosphoric acid, sodium phosphate, citric acid, sodium citrate, succinic acid, sodium succinate, tartaric acid, sodium stannate, or the like can be used alone or in combination of two or more. have. The acidity of the dentifrice composition is generally 5-8.

Titanium oxide or the like may be used as the brightener, and the amount of the brightener is generally 0.1 to 2 wt% based on the total weight of the toothpaste composition.

The toothpaste composition for promoting dental health according to the present invention may be prepared not only in toothpaste but also in other forms of formulation, for example, oral cleanser, oral spray, gum, ointment or patch.

In addition, the present invention provides a toothpaste that can prevent the phosphate and calcium salts from reacting with each other to solidify.

Specifically, the present invention is a phosphate; And a first composition comprising one or a mixture of two or more selected from the group consisting of gelatin, phosphoserine, and polylysine, and a second composition including calcium salt. In another aspect, the present invention comprises a calcium salt and the first composition comprising a phosphate; And a second composition comprising one or a mixture of two or more selected from the group consisting of gelatin, phosphoserine, and polylysine.

As such, the first composition and the second composition are separated separately, and the first composition and the second composition are mixed in the process of squeezing the toothpaste so that the phosphate and calcium salt react with each other to prevent the toothpaste from hardening. Synergistic effect of the mixing with the calcium salt can be expected.

The content of the phosphate is preferably 0.001 to 20% by weight relative to the total weight of the toothpaste, and when the content is less than 0.001% by weight, the remineralization effect of the tooth is lowered, and when it exceeds 20% by weight, discoloration by phosphate occurs. Can be difficult to apply.

The content of the calcium salt is preferably 0.001 to 50% by weight relative to the total weight of the toothpaste, and when the content is less than 0.001% by weight, the remineralization effect of the tooth is lowered, and when it exceeds 50% by weight, the stability of the formulation is greatly reduced. can do.

The content of one or two or more mixtures selected from the group consisting of gelatin, phosphoserine and polylysine is preferably 0.01 to 15% by weight relative to the total weight of the toothpaste, and when the content is less than 0.01% by weight, the hardness of the tooth or The synergistic effect of impact strength is poor and, if it exceeds 15% by weight, the stability of the formulation can be greatly reduced.

Phosphate, calcium salt, gelatin, phosphoserine and polylysine used in the toothpaste are as defined in the toothpaste composition.

Tooth decay by using the toothpaste composition or toothpaste for tooth health promotion of the present invention can prevent tooth decay and ultimately improve dental health.

1 is a differential scanning electron micrograph of the decalcified tooth specimen of Experimental Example 2.
Figure 2 is a differential scanning electron micrograph of the remineralized tooth specimen of Experimental Example 2.

Hereinafter, embodiments of the present invention will be described in detail to facilitate understanding of the present invention. However, the embodiments according to the present invention can be modified into various other forms, and the scope of the present invention should not be construed as being limited to the following embodiments. Embodiments of the present invention are provided to more fully describe the present invention to those skilled in the art.

<Examples 1 to 11 and Comparative Examples 1 to 4>

Toothpaste compositions of Examples 1 to 11 and Comparative Examples 1 to 4 were prepared by the following method using the compositional ingredients and contents (% by weight) shown in Table 1 below, and by the conventional method using the toothpaste composition Toothpaste was prepared.

First, xanthan gum, sodium saccharin, methyl paraoxybenzoate, calcium salt, phosphate, gelatin, and phosphoserin are dispersed in a sorbitol solution, which is a wet component, and mixed with purified water in a mixer firstly, precipitated silica as an abrasive and sodium fluoride as an agent. Was added and mixed secondly. Finally, a foaming agent was prepared by adding sodium lauryl sulfate, a perfume component, and polylysine, and mixing them under vacuum.

However, if calcium salt and phosphate coexist, toothpaste hardening may occur, and thus, in Example 11, the first composition including calcium salt is prepared in chamber 1 using a dual chamber, and the phosphate-containing agent is used. The second composition was prepared separately in chamber 2, so that the first composition and the second composition were mixed during the toothpaste process.

ingredient Example One 2 3 4 5 6 7 8 Precipitated silica 20 20 20 20 20 20 20 20 Sorbitol 40 40 40 40 40 40 40 40 Sodium Lauryl Sulfate 2 2 2 2 2 2 2 2 Saccharin Sodium 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 Methyl paraoxybenzoate 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 Xanthan gum 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 Calcium salt Calcium chloride 2 2 2 2 - - - - Dicalcium Phosphate - - - - - - - - Calcium carbonate - - - - - - - - phosphate Sodium monophosphate - - - - 3 3 3 3 Trisodium Phosphate - - - - 2 2 2 2 gelatin One - - One One - - One Phosphoserine - One - One - One - One Polylysine - - One One - - One One Sodium fluoride 0.22 0.22 0.22 0.22 0.22 0.22 0.22 0.22 Purified water 33.28 33.28 33.28 31.28 30.28 30.28 30.28 28.28
ingredient Example Comparative example 9 10 11
(2chamber) One 2 3 4 Chamber 1 Chamber 2 Precipitated silica 2 2 20 20 20 20 20 20 Sorbitol 40 40 40 40 40 40 40 40 Sodium Lauryl Sulfate 2 2 2 2 2 2 2 2 Saccharin Sodium 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 Methyl paraoxybenzoate 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 Xanthan gum 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 Calcium salt Calcium chloride - - - 2 2 - 2 - Dicalcium Phosphate 40 - - - - - - - Calcium carbonate - 38 - - - - - - phosphate Sodium monophosphate - - 3 - - 3 3 - Trisodium Phosphate - - 2 - - 2 2 - gelatin One One 2 - - - - - Phosphoserine - - - - - - - - Polylysine - - - - - - - - Sodium fluoride - - 0.22 0.22 - - - - Purified water 13.5 15.5 29.28 34.28 34.5 31.5 29.5 36.5

Experimental Example 1 Measurement of Hardness of Teeth

Hardness change was measured after remineralization of the teeth using the toothpaste of Examples 1 to 11 and Comparative Examples 1 to 4 on the decalcified tooth specimens.

First, bovine teeth specimens were treated with 0.1M lactic acid solution for 4 days to decalcify until Vickers hardness was 28 to 45 (initial hardness). After the experimental toothpaste was treated for 1 minute on the decalcified specimen, the specimen was washed with tap water and then treated with artificial saliva for 59 minutes. The treatment of the experimental toothpaste and artificial saliva as described above was repeated once again. The specimen was then demineralized by treatment with 0.1 M lactic acid for 4 hours. Then, the test toothpaste and artificial saliva were treated twice as described above to remineralize the specimen. This process (experimental toothpaste → artificial saliva → experimental toothpaste → artificial saliva → lactic acid → experimental toothpaste → artificial saliva → experimental toothpaste → artificial saliva) was performed for 20 days and then washed with distilled water and remineralized using Vickers hardness tester. The final hardness of the specimen was measured and the difference from the initial hardness was shown in Table 2 below.

In this case, the initial hardness was measured by using a Vickers hardness tester (AKASHI, Japan) prepared with an image observation system to virtually divide the specimen into four equal parts and measure the hardness of the four divided points, and set the average value as the initial hardness. In addition, the final hardness was measured by virtually dividing the hardness of the portion adjacent to the portion where the initial hardness of the specimen was measured, and then measuring the hardness of the quadrant. The average value was defined as the final hardness.

Hardness change (△ VHN) Statistical significance Example 1 25.78 ± 2.33 ** Example 2 23.12 ± 4.12 ** Example 3 21.56 ± 4.78 ** Example 4 28.38 ± 4.98 ** Example 5 33.77 ± 5.32 ** Example 6 31.78 ± 5.71 ** Example 7 31.15 ± 4.88 ** Example 8 39.01 ± 5.13 ** Example 9 20.15 ± 3.11 ** Example 10 25.16 ± 3.69 ** Example 11 51.23 ± 5.88 ** Comparative Example 1 11.21 ± 2.01 * Comparative Example 2 13.56 ± 2.35 * Comparative Example 3 21.03 ± 3.56 ** Comparative Example 4 6.10 ± 2.39

From the results of Table 2, the tooth using a toothpaste containing calcium salt and / or phosphate (Examples 1 to 11 and Comparative Examples 1 to 3) is a toothpaste containing no calcium salt and / or phosphate (Comparative Example 4) Significantly higher hardness compared to teeth used, indicating that calcium salts and / or phosphates contribute to tooth remineralization.

In particular, teeth using toothpaste (Examples 1 to 11) comprising calcium salts and / or phosphates and biocompatible organic materials (gelatin, phosphoserine, polylysine) include calcium salts and / or phosphates and are biocompatible. Compared with teeth using toothpastes (Comparative Examples 1 to 3) containing no organic substance, the hardness was about 2 times higher. In addition, teeth using toothpaste containing calcium salt, phosphate and biocompatible organic substance (gelatin) (Example 11) were significantly harder than teeth using toothpaste containing only calcium salt and phosphate (Comparative Example 3). It can be seen. From these results, it can be seen that the use of biocompatible organic materials with calcium salts and / or phosphates can significantly promote remineralization of teeth.

And, when comparing Examples 1 to 11 and Comparative Examples 1 to 4 of the present invention showed a statistically significant increase (p <0.01).

Experimental Example 2 Remineralization of Teeth

In order to confirm the degree of remineralization of the tooth using the toothpaste of Example 11, a differential scanning electron microscope was used for the demineralized tooth specimen of Experimental Example 1 and the remineralized tooth specimen using the toothpaste of Example 11. Analyzes are shown in FIGS. 1 and 2, respectively.

It can be seen that the enamel tissue of the remineralized tooth of FIG. 2 is significantly filled compared to the enamel tissue of the demineralized tooth of FIG. 1, from which the remineralization efficiency of the toothpaste of the present invention is very high.

Claims (13)

Phosphates, calcium salts or mixtures thereof and
Toothpaste composition for dental health, characterized in that it comprises a mixture of one or two or more selected from the group consisting of gelatin, phosphoserine and polylysine. According to claim 1, wherein the phosphate is a toothpaste composition, characterized in that 0.001 to 20% by weight relative to the total weight of the toothpaste composition. According to claim 1, wherein the calcium salt or a mixture of calcium salt and phosphate is toothpaste composition, characterized in that 0.001 to 50% by weight relative to the total weight of the toothpaste composition. The dentifrice composition according to claim 1, wherein the one or two or more mixtures selected from the group consisting of gelatin, phosphoserine and polylysine is 0.01 to 15% by weight relative to the total weight of the dentifrice composition. The method of claim 1, wherein the phosphate salt is selected from the group consisting of sodium monophosphate, sodium diphosphate, sodium triphosphate, potassium monophosphate, potassium diphosphate, potassium triphosphate, iron phosphate and magnesium triphosphate. Toothpaste composition, characterized in that at least one selected. The method according to claim 1, wherein the calcium salt is hydrous calcium chloride (CaCl ₂ .xH ₂ O), anhydrous calcium chloride (CaCl ₂ ), calcium phosphate, calcium fluoride (CaF ₂ ), calcium citrate, calcium gluconate, calcium oxide, Toothpaste composition, characterized in that at least one selected from the group consisting of calcium ascorbate, calcium lactate, monobasic calcium phosphate, dibasic calcium phosphate, tribasic calcium phosphate, calcium carbonate, calcium pantothenate and calcium hydroxide. phosphate; And one or two or more mixtures selected from the group consisting of gelatin, phosphoserine and polylysine, and
Toothpaste for dental health, comprising a second composition comprising a calcium salt. A first composition comprising a phosphate and
Calcium salts; And a second composition comprising one or a mixture of two or more selected from the group consisting of gelatin, phosphoserine and polylysine. The toothpaste of claim 7 or 8, wherein the phosphate salt is 0.001 to 20% by weight based on the total weight of the toothpaste. The toothpaste of claim 7 or 8, wherein the calcium salt is 0.001 to 50% by weight based on the total weight of the toothpaste. The toothpaste of claim 7 or 8, wherein the one or two or more mixtures selected from the group consisting of gelatin, phosphoserine and polylysine is 0.01 to 15% by weight relative to the total weight of the toothpaste. The method of claim 7 or 8, wherein the phosphate salt is sodium monophosphate, sodium diphosphate, sodium triphosphate, potassium monophosphate, potassium diphosphate, potassium triphosphate, iron phosphate and magnesium triphosphate. Toothpaste, characterized in that at least one selected from the group consisting of. The method according to claim 7 or 8, wherein the calcium salt is hydrous calcium chloride (CaCl ₂ .xH ₂ O), anhydrous calcium chloride (CaCl ₂ ), glycero phosphate, calcium fluoride (CaF ₂ ), calcium citrate, calcium gluconate Toothpaste, characterized in that at least one selected from the group consisting of calcium oxide, calcium ascorbate, calcium lactate, calcium monophosphate, calcium diphosphate, tricalcium phosphate, calcium carbonate, calcium pantothenate and calcium hydroxide.

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