KR20120014122A - 분석물, 특히 미코톡신의 검증 및 정량적 분석을 위한 장치 및 방법 - Google Patents
분석물, 특히 미코톡신의 검증 및 정량적 분석을 위한 장치 및 방법 Download PDFInfo
- Publication number
- KR20120014122A KR20120014122A KR1020117023603A KR20117023603A KR20120014122A KR 20120014122 A KR20120014122 A KR 20120014122A KR 1020117023603 A KR1020117023603 A KR 1020117023603A KR 20117023603 A KR20117023603 A KR 20117023603A KR 20120014122 A KR20120014122 A KR 20120014122A
- Authority
- KR
- South Korea
- Prior art keywords
- analyte
- cartridge
- sample fluid
- immunoassay
- control assay
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 231100000678 Mycotoxin Toxicity 0.000 title claims abstract description 48
- 239000002636 mycotoxin Substances 0.000 title claims abstract description 48
- 238000000034 method Methods 0.000 title claims abstract description 26
- 238000004445 quantitative analysis Methods 0.000 title claims abstract description 14
- 238000010200 validation analysis Methods 0.000 title claims abstract description 8
- 239000000523 sample Substances 0.000 claims description 99
- 239000003153 chemical reaction reagent Substances 0.000 claims description 45
- 239000012530 fluid Substances 0.000 claims description 45
- 238000003556 assay Methods 0.000 claims description 41
- 238000001514 detection method Methods 0.000 claims description 39
- 239000012491 analyte Substances 0.000 claims description 35
- 238000005259 measurement Methods 0.000 claims description 33
- 230000003287 optical effect Effects 0.000 claims description 26
- 238000003018 immunoassay Methods 0.000 claims description 25
- 230000027455 binding Effects 0.000 claims description 23
- 238000004458 analytical method Methods 0.000 claims description 20
- 230000005284 excitation Effects 0.000 claims description 18
- 239000000427 antigen Substances 0.000 claims description 14
- 102000036639 antigens Human genes 0.000 claims description 13
- 108091007433 antigens Proteins 0.000 claims description 13
- 239000010409 thin film Substances 0.000 claims description 12
- 239000000463 material Substances 0.000 claims description 10
- 239000011159 matrix material Substances 0.000 claims description 10
- 238000006243 chemical reaction Methods 0.000 claims description 8
- 238000011088 calibration curve Methods 0.000 claims description 7
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 claims description 7
- 238000002073 fluorescence micrograph Methods 0.000 claims description 5
- 230000001678 irradiating effect Effects 0.000 claims description 3
- 230000008569 process Effects 0.000 claims description 3
- 230000009260 cross reactivity Effects 0.000 claims description 2
- 238000000018 DNA microarray Methods 0.000 description 42
- 239000010410 layer Substances 0.000 description 21
- 239000000243 solution Substances 0.000 description 18
- 238000007789 sealing Methods 0.000 description 12
- 239000010408 film Substances 0.000 description 8
- 239000011521 glass Substances 0.000 description 7
- 230000003993 interaction Effects 0.000 description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 102000004169 proteins and genes Human genes 0.000 description 6
- 238000013461 design Methods 0.000 description 5
- 239000007850 fluorescent dye Substances 0.000 description 5
- 238000011534 incubation Methods 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- LINOMUASTDIRTM-QGRHZQQGSA-N deoxynivalenol Chemical compound C([C@@]12[C@@]3(C[C@@H](O)[C@H]1O[C@@H]1C=C(C([C@@H](O)[C@@]13CO)=O)C)C)O2 LINOMUASTDIRTM-QGRHZQQGSA-N 0.000 description 4
- 229930002954 deoxynivalenol Natural products 0.000 description 4
- TVACALAUIQMRDF-UHFFFAOYSA-N dodecyl dihydrogen phosphate Chemical compound CCCCCCCCCCCCOP(O)(O)=O TVACALAUIQMRDF-UHFFFAOYSA-N 0.000 description 4
- 238000007430 reference method Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- LINOMUASTDIRTM-UHFFFAOYSA-N vomitoxin hydrate Natural products OCC12C(O)C(=O)C(C)=CC1OC1C(O)CC2(C)C11CO1 LINOMUASTDIRTM-UHFFFAOYSA-N 0.000 description 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 229930040373 Paraformaldehyde Natural products 0.000 description 3
- 241000209140 Triticum Species 0.000 description 3
- 235000021307 Triticum Nutrition 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 238000012937 correction Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000005206 flow analysis Methods 0.000 description 3
- 229940127121 immunoconjugate Drugs 0.000 description 3
- 239000003550 marker Substances 0.000 description 3
- 238000002493 microarray Methods 0.000 description 3
- 102000039446 nucleic acids Human genes 0.000 description 3
- 108020004707 nucleic acids Proteins 0.000 description 3
- 150000007523 nucleic acids Chemical class 0.000 description 3
- BPUBBGLMJRNUCC-UHFFFAOYSA-N oxygen(2-);tantalum(5+) Chemical compound [O-2].[O-2].[O-2].[O-2].[O-2].[Ta+5].[Ta+5] BPUBBGLMJRNUCC-UHFFFAOYSA-N 0.000 description 3
- 229920006324 polyoxymethylene Polymers 0.000 description 3
- 239000002356 single layer Substances 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 230000009870 specific binding Effects 0.000 description 3
- PBCFLUZVCVVTBY-UHFFFAOYSA-N tantalum pentoxide Inorganic materials O=[Ta](=O)O[Ta](=O)=O PBCFLUZVCVVTBY-UHFFFAOYSA-N 0.000 description 3
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
- 239000000020 Nitrocellulose Substances 0.000 description 2
- 229940098773 bovine serum albumin Drugs 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 239000003365 glass fiber Substances 0.000 description 2
- 238000005470 impregnation Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 229920001220 nitrocellulos Polymers 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 238000011533 pre-incubation Methods 0.000 description 2
- 238000004451 qualitative analysis Methods 0.000 description 2
- 238000011002 quantification Methods 0.000 description 2
- 239000012488 sample solution Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 229910052715 tantalum Inorganic materials 0.000 description 2
- 238000009423 ventilation Methods 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 229920000936 Agarose Polymers 0.000 description 1
- 244000105624 Arachis hypogaea Species 0.000 description 1
- 241000723382 Corylus Species 0.000 description 1
- 235000007466 Corylus avellana Nutrition 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 240000005979 Hordeum vulgare Species 0.000 description 1
- 235000007340 Hordeum vulgare Nutrition 0.000 description 1
- 108091005461 Nucleic proteins Proteins 0.000 description 1
- 108010058846 Ovalbumin Proteins 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 241000209056 Secale Species 0.000 description 1
- 235000007238 Secale cereale Nutrition 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- 108010071390 Serum Albumin Proteins 0.000 description 1
- 102000007562 Serum Albumin Human genes 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 238000012742 biochemical analysis Methods 0.000 description 1
- 238000004159 blood analysis Methods 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 238000002967 competitive immunoassay Methods 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000005670 electromagnetic radiation Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000002657 fibrous material Substances 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 102000034287 fluorescent proteins Human genes 0.000 description 1
- 108091006047 fluorescent proteins Proteins 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 229920001477 hydrophilic polymer Polymers 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 239000002346 layers by function Substances 0.000 description 1
- 238000000813 microcontact printing Methods 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 230000009149 molecular binding Effects 0.000 description 1
- 239000003068 molecular probe Substances 0.000 description 1
- 230000009871 nonspecific binding Effects 0.000 description 1
- 229940092253 ovalbumin Drugs 0.000 description 1
- 238000002161 passivation Methods 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 238000005375 photometry Methods 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920000098 polyolefin Polymers 0.000 description 1
- -1 polyoxymethylene Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 238000001454 recorded image Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000010414 supernatant solution Substances 0.000 description 1
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 235000014101 wine Nutrition 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5302—Apparatus specially adapted for immunological test procedures
- G01N33/5304—Reaction vessels, e.g. agglutination plates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0819—Microarrays; Biochips
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N2021/0325—Cells for testing reactions, e.g. containing reagents
- G01N2021/0328—Arrangement of two or more cells having different functions for the measurement of reactions
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N2021/0346—Capillary cells; Microcells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N2021/7769—Measurement method of reaction-produced change in sensor
- G01N2021/7786—Fluorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N21/0332—Cuvette constructions with temperature control
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N21/05—Flow-through cuvettes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
- G01N21/274—Calibration, base line adjustment, drift correction
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/37—Assays involving biological materials from specific organisms or of a specific nature from fungi
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/02—Food
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/02—Food
- G01N33/10—Starch-containing substances, e.g. dough
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plasma & Fusion (AREA)
- Clinical Laboratory Science (AREA)
- Dispersion Chemistry (AREA)
- Optics & Photonics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09157714.8 | 2009-04-09 | ||
| EP09157714 | 2009-04-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20120014122A true KR20120014122A (ko) | 2012-02-16 |
Family
ID=42124716
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020117023603A Withdrawn KR20120014122A (ko) | 2009-04-09 | 2010-03-26 | 분석물, 특히 미코톡신의 검증 및 정량적 분석을 위한 장치 및 방법 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20130203613A1 (enExample) |
| EP (1) | EP2417436A1 (enExample) |
| JP (1) | JP2012523549A (enExample) |
| KR (1) | KR20120014122A (enExample) |
| CN (1) | CN102460127A (enExample) |
| AP (1) | AP2011005905A0 (enExample) |
| AR (1) | AR076201A1 (enExample) |
| AU (1) | AU2010234063A1 (enExample) |
| BR (1) | BRPI1015212A2 (enExample) |
| CA (1) | CA2758065A1 (enExample) |
| CL (1) | CL2011002509A1 (enExample) |
| CO (1) | CO6440576A2 (enExample) |
| CR (1) | CR20110530A (enExample) |
| EA (1) | EA201171178A1 (enExample) |
| EC (1) | ECSP11011376A (enExample) |
| MX (1) | MX2011010586A (enExample) |
| WO (1) | WO2010115530A1 (enExample) |
| ZA (1) | ZA201107242B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101335032B1 (ko) * | 2012-11-06 | 2013-12-02 | (주)플렉센스 | 시료의 정량적 분석을 위한 시료측정 카트리지 및 시료 정량 분석 장치 |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9812597B2 (en) * | 2014-08-12 | 2017-11-07 | Personal Genomics, Inc. | Optical sensor and manufacturing method thereof |
| AU2016323072B2 (en) * | 2015-09-14 | 2019-09-19 | Essenlix Corporation | Device and system for collecting and analyzing vapor condensate, particularly exhaled breath condensate, as well as method of using the same |
| EP3483592B1 (en) * | 2016-07-05 | 2020-07-22 | Konica Minolta, Inc. | Biological material quantifying method, image processing device, pathological diagnosis support system and program |
| EP3273236B1 (de) * | 2016-07-18 | 2018-10-10 | R-Biopharm Aktiengesellschaft | Verfahren zur extraktion von mykotoxinen aus getreiden, anderen lebensmitteln und futtermitteln |
| KR101999260B1 (ko) * | 2016-09-30 | 2019-07-12 | 삼성전자주식회사 | 검체 분석 장치 및 그 측정방법 |
| WO2018138304A1 (en) * | 2017-01-30 | 2018-08-02 | Miltenyi Biotec Gmbh | Printed flow cell for photometer |
| NL2021691B1 (en) * | 2018-09-24 | 2020-05-07 | Lely Patent Nv | Milking system with detection system |
| WO2020142902A1 (zh) | 2019-01-08 | 2020-07-16 | 京东方科技集团股份有限公司 | 流体检测面板和流体检测装置 |
| CN109632660B (zh) * | 2019-01-17 | 2022-04-05 | 京东方科技集团股份有限公司 | 流体检测面板 |
| JP7508122B2 (ja) | 2019-07-29 | 2024-07-01 | エイブル株式会社 | センサ素子の製造方法、センサ素子、センサ素子保持体及び蛍光式センサシステム |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL68506A (en) | 1982-05-04 | 1988-06-30 | Syva Co | Simultaneous calibration heterogeneous immunoassay method and device and kit for use therein |
| DE69505370T2 (de) | 1994-05-27 | 1999-04-01 | Novartis Ag, Basel | Verfahren und sensor zum nachweis abklingend angeregter lumineszenz |
| WO1999052633A1 (en) * | 1998-04-14 | 1999-10-21 | Ivd Systems | Test cartridge with a single inlet port |
| WO2001013096A1 (de) | 1999-08-13 | 2001-02-22 | Zeptosens Ag | Vorrichtung und verfahren zur multianalytbestimmung |
| CN1351177A (zh) * | 2001-08-14 | 2002-05-29 | 上海晶泰生物技术有限公司 | 生物芯片点样阵列的设计 |
| DE10313515A1 (de) * | 2001-09-28 | 2004-10-14 | Biotez Berlin-Buch Gmbh | Biochip zum quantitativen fotometrischen Nachweis von Biomolekülen |
| JP2004069397A (ja) * | 2002-08-02 | 2004-03-04 | Nec Corp | 分析チップおよび分析装置 |
| JP2005537486A (ja) * | 2002-09-03 | 2005-12-08 | ツェプトゼンス アクチエンゲゼルシャフト | 分析対象物が試料中で固定化された特異的結合パートナーとして測定される分析プラットフォーム及び検出法 |
| WO2005088300A1 (en) | 2004-03-16 | 2005-09-22 | Fuji Photo Film Co., Ltd. | Assay chip |
| JP2006208386A (ja) * | 2005-01-26 | 2006-08-10 | Agilent Technol Inc | 複数の標識を有するアッセイテスト細片及びその読み取り法 |
| DE102005062377A1 (de) | 2005-12-23 | 2007-06-28 | Bayer Technology Services Gmbh | Vorrichtung und Verfahren zum Nachweis von Mykotoxinen |
| US7256008B2 (en) * | 2006-01-06 | 2007-08-14 | Abbott Laboratories | Determination of concentration of FK778 by competitive immunoassay |
| JP5080186B2 (ja) * | 2007-09-26 | 2012-11-21 | 富士フイルム株式会社 | 分子分析光検出方法およびそれに用いられる分子分析光検出装置、並びにサンプルプレート |
-
2010
- 2010-03-26 EA EA201171178A patent/EA201171178A1/ru unknown
- 2010-03-26 KR KR1020117023603A patent/KR20120014122A/ko not_active Withdrawn
- 2010-03-26 JP JP2012503889A patent/JP2012523549A/ja active Pending
- 2010-03-26 MX MX2011010586A patent/MX2011010586A/es not_active Application Discontinuation
- 2010-03-26 CA CA2758065A patent/CA2758065A1/en not_active Abandoned
- 2010-03-26 EP EP10712339A patent/EP2417436A1/de not_active Withdrawn
- 2010-03-26 AP AP2011005905A patent/AP2011005905A0/xx unknown
- 2010-03-26 US US13/263,373 patent/US20130203613A1/en not_active Abandoned
- 2010-03-26 AU AU2010234063A patent/AU2010234063A1/en not_active Abandoned
- 2010-03-26 CN CN2010800257383A patent/CN102460127A/zh active Pending
- 2010-03-26 BR BRPI1015212A patent/BRPI1015212A2/pt not_active IP Right Cessation
- 2010-03-26 WO PCT/EP2010/001924 patent/WO2010115530A1/de not_active Ceased
- 2010-04-05 AR ARP100101131A patent/AR076201A1/es not_active Application Discontinuation
-
2011
- 2011-10-04 ZA ZA2011/07242A patent/ZA201107242B/en unknown
- 2011-10-06 EC EC2011011376A patent/ECSP11011376A/es unknown
- 2011-10-07 CO CO11132884A patent/CO6440576A2/es active IP Right Grant
- 2011-10-07 CL CL2011002509A patent/CL2011002509A1/es unknown
- 2011-10-07 CR CR20110530A patent/CR20110530A/es unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101335032B1 (ko) * | 2012-11-06 | 2013-12-02 | (주)플렉센스 | 시료의 정량적 분석을 위한 시료측정 카트리지 및 시료 정량 분석 장치 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20130203613A1 (en) | 2013-08-08 |
| MX2011010586A (es) | 2011-10-19 |
| BRPI1015212A2 (pt) | 2016-05-03 |
| WO2010115530A1 (de) | 2010-10-14 |
| CN102460127A (zh) | 2012-05-16 |
| ECSP11011376A (es) | 2011-11-30 |
| CA2758065A1 (en) | 2010-10-14 |
| ZA201107242B (en) | 2012-12-27 |
| EA201171178A1 (ru) | 2012-05-30 |
| CL2011002509A1 (es) | 2012-04-20 |
| EP2417436A1 (de) | 2012-02-15 |
| AR076201A1 (es) | 2011-05-26 |
| AP2011005905A0 (en) | 2011-10-31 |
| JP2012523549A (ja) | 2012-10-04 |
| CR20110530A (es) | 2012-01-31 |
| CO6440576A2 (es) | 2012-05-15 |
| AU2010234063A1 (en) | 2011-11-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR20120014122A (ko) | 분석물, 특히 미코톡신의 검증 및 정량적 분석을 위한 장치 및 방법 | |
| KR20120013316A (ko) | 분석물의 생물검정을 위한 일회용 마이크로유체 시험 카트리지 | |
| US7396675B2 (en) | Kit and method for determining a plurality of analytes | |
| EP3430393B1 (en) | Microfluidic device, system and method | |
| US20020110839A1 (en) | Micro-array evanescent wave fluorescence detection device | |
| US20110124130A1 (en) | Device and method for analysis of samples with depletion of analyte content | |
| JP2004510130A5 (enExample) | ||
| NO332532B1 (no) | Fremgangsmate for a detektere et malantigen i en fluidprove samt engangsinnretning egnet for a praktisere nevnte fremgangsmate | |
| EP2646152A1 (en) | Sample metering device and assay device with integrated sample dilution | |
| US20120316077A1 (en) | System And Method For Detection And Analysis Of A Molecule In A Sample | |
| JP5946275B2 (ja) | 対照と較正の組み合わせゾーンを有するテスト要素 | |
| US20220266248A1 (en) | Assay sample volume normalization | |
| US20050032089A1 (en) | Sample preparation for colorimetric and fluorescent assays as implemented on optical analysis discs | |
| WO2003025547A1 (en) | Method and device for screening analytes using surface plasmon resonance | |
| RU2776889C1 (ru) | Способ количественного определения селективно связанных белков-маркеров заболеваний в планарных ячейках биочипа и устройство для его осуществления | |
| HK1163817B (en) | Test element having combined control and calibration zone |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20111007 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| N231 | Notification of change of applicant | ||
| PN2301 | Change of applicant |
Patent event date: 20130522 Comment text: Notification of Change of Applicant Patent event code: PN23011R01D |
|
| PC1203 | Withdrawal of no request for examination |