KR20110137907A - Dermal filler using ceramic beads - Google Patents
Dermal filler using ceramic beads Download PDFInfo
- Publication number
- KR20110137907A KR20110137907A KR1020100057905A KR20100057905A KR20110137907A KR 20110137907 A KR20110137907 A KR 20110137907A KR 1020100057905 A KR1020100057905 A KR 1020100057905A KR 20100057905 A KR20100057905 A KR 20100057905A KR 20110137907 A KR20110137907 A KR 20110137907A
- Authority
- KR
- South Korea
- Prior art keywords
- beads
- ceramic
- ceramic beads
- filler composition
- weight
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/60—Materials for use in artificial skin
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Materials For Medical Uses (AREA)
Abstract
The present invention is to anionize the surface of the ceramic beads (ceramic beads) to generate a repulsive force between the ceramic beads, thereby improving the stability of the injection as well as easy to inject, and at the same time to maintain a stable volume expansion effect for a long time The present invention relates to a filler composition for filling skin using ceramic beads, which includes hydroxyapatite beads, bioglass beads, calcium carbonate beads, titanium dioxide beads, barium sulfate (BaSO 4 ) beads, alumina (Al 2 O 3 ) beads, and zirconia ( It characterized in that the anionic polymer is adsorbed or covalently bonded to the surface of the ceramic beads such as ZiO 2 ) beads.
Description
The present invention relates to a filler (filler) composition for filling the skin, and more particularly, by anionizing the surface of the ceramic beads (ceramic beads) to generate a repulsive force between the ceramic beads, thereby improving the stability of the injection as well as injection The present invention relates to a filler composition for filling skin using ceramic beads, which facilitates and at the same time maintains a bulking effect stably for a long time.
Human skin tissue is maintained by extracellular matrix including proteins such as collagen and elastin and glycosaminoglycans, and when soft tissue defects occur due to external shock, disease or aging Its shape has been restored and corrected by inserting biological tissue or synthetic polymer chemicals into the site to expand the soft tissue.
On the other hand, a substance similar to skin tissue is used to improve wrinkles or contour correction by inserting it into a specific area and expanding soft tissue, called a soft tissue augmentation material, generally called a dermal filler.
These dermal fillers are short-term fillers with a duration of 12 months or less, mid-term fillers with 12-24 months, and long-term fillers that last more than 2 years. Can be divided into
Collagen and hyaluronic acid are representative examples of the short-term filler. Collagen and hyaluronic acid are currently being actively researched for long-lasting in the human body by increasing molecular weight by cross-linking.
Currently used collagen filler products include Evolence using pig collagen, Zyderm and Zyplast using bovine collagen, and Cosmoderm and Cosmoplast using collagen of human body.
Filler products based on hyaluronic acid include Hilar Form and Touchline, which use collagen of animals, especially roosters, and Restylane, Juviderm, and Hyaluderm, which use hyaluronic acid cultured with bacteria.
Some products use polymer beads that do not decompose in order to extend the working period of the filler. The polymer beads used here include dextran, polymethylmethacrylate (PMMA), and polyacrylamide (PMMA). These polymer beads have the advantage that it takes a long time to decompose in vivo, but synthetic polymers generally do not have good biocompatibility with human tissue.
Filler products using ceramic beads that are more biocompatible than polymers while retaining in the body for a long time include Radiesse using hydroxyapatite beads, which are 25-45 micrometers to prevent them from being detected by white blood cells in the human body. Has the size of. Radiesse lasts up to about two years, with minor side effects on the human body.
The ceramic beads are more biocompatible than synthetic polymers because the inorganic material that forms the ceramic is part of our body.
In addition, ceramics are hydrophilic, so the adsorption of proteins in the body does not occur well, so that there is little foreign body reaction due to the activation of complement.
However, there is a problem to be solved in order to apply the ceramic beads as a filler.
That is, the first is that the rate of degradation in the body is slow or does not degrade, so the effect should last as long as possible.
Second, the solution containing the ceramic beads should satisfy the physical properties as a filler, such that there should be no property of tangling with each other in the solution state, the viscosity is low at the time of injection should easily pass through the needle.
The present invention has been made under the above-described background, and an object of the present invention is to provide a filler composition for filling skin using ceramic beads of biosynthetic ceramic beads having a longer effect (volume enlargement) duration than filler products using hydroxyapatite beads. Is in.
In addition, another object of the present invention is to overcome the problem of being entangled with each other on the solution, which is a general property of the ceramic bead solution, thereby increasing the viscosity, the filler composition for filling the skin using ceramic beads that can be easily injected into the skin through the needle Is to provide.
The present invention for achieving the above object, hydroxyapatite beads, bioglass beads, calcium carbonate beads, titanium dioxide beads, barium sulfate (BaSO 4 ) beads, alumina (Al 2 O 3 ) beads, zirconia (ZiO 2 The anionic polymer is adsorbed or covalently bonded to the surface of ceramic beads such as beads.
In addition, the polymer that can be used as the anionic polymer according to the invention is characterized in that one of polyacrylic acid, polymethacrylic acid, polystyrene sulfonate, polyvinylsulfonate, hyaluronic acid, carboxymethyl cellulose.
In addition, the filler composition for filling skin according to the present invention is characterized by comprising 40 to 80 parts by weight of ceramic beads, and 0.001 to 1 parts by weight of anionic polymer bonded to the surface of the ceramic beads with respect to 100 parts by weight of the filler composition. It is done.
In addition, the ceramic beads according to the invention is characterized in that the size of 25-100 micrometers.
In addition, the filler composition for skin filling according to the present invention, 40 to 80 parts by weight of the ceramic beads, 0.001 to 1 parts by weight of anionic polymer bonded to the surface of the ceramic beads, based on 100 parts by weight of the filler composition, It is characterized by including a neutral polymer 0 to 10 parts by weight.
In addition, the neutral polymer according to the present invention is characterized in that one of polyethylene glycol (PEG), polylactic glycolamide (polylactic glycolamide, PLGA), polyvinyl alcohol (polyvinyl alcohol, PVA), poloxamer (Polloxamer) do.
As described above, the present invention has a very slow decomposition rate in the human body, and in theory, does not decompose and disappear at the injected position, and thus a permanent wrinkle forming effect can be expected.
In addition, the present invention is characterized in that when the anionic polymer is bonded to the surface, the ceramic beads repel each other by electrostatic repulsive force and thus do not aggregate with each other even at high concentrations. Injection can also be made through small diameter needles to reduce pain in patients and reduce the possibility of side effects that can occur during high pressure on high syringes during the procedure.
In addition, the present invention provides an easy effect of preparing the skin filler that does not agglomerate for a long time because the ceramic beads repel by electrostatic repulsive force.
Hereinafter, preferred embodiments of the present invention will be described in more detail.
Filler composition for skin filling using ceramic beads according to the present invention,
Anionic polymer on the surface of ceramic beads such as hydroxyapatite beads, bioglass beads, calcium carbonate beads, titanium dioxide beads, barium sulfate (BaSO 4 ) beads, alumina (Al 2 O 3 ) beads, zirconia (ZiO 2 ) beads Is composed by adsorption or covalent bonding.
The method of adsorbing or covalently attaching the anionic polymer to the ceramic beads may be implemented in such a way that the anionic polymer is adsorbed by an electrostatic attraction to an atom that is a cation of the ceramic bead, or in another method, By covalent bonding.
Here, the polymer that can be used as the anionic polymer may be one of polyacrylic acid, polymethacrylic acid, polystyrene sulfonate, polyvinylsulfonate, hyaluronic acid, and carboxymethylcellulose.
According to the present invention, the filler composition for skin filling comprises 40 to 80 parts by weight of ceramic beads and 0.001 to 1 part by weight of anionic polymer bonded to the surface of the ceramic beads with respect to 100 parts by weight of the filler composition. do.
The ceramic beads also use sizes of 25-100 micrometers.
In addition, the filler composition for filling the skin of the present invention may be used as a physiological saline or a solvent, but may be used by mixing 0-10% of a neutral polymer so that precipitation does not separate during storage.
Wherein the neutral polymer is to lower the viscosity of the filler composition for filling the skin of the present invention to facilitate injection through injection, the neutral polymer is a polyethylene glycol (polyethylene glycol, PEG) functions as a hydroxypropyl methyl cellulose , Polylactic glycolamide (PLGA), polyvinyl alcohol (PVA), poloxamer (Polloxamer) can be one of.
Therefore, the filler composition for skin filling of the present invention containing the neutral polymer has an amount of 0.001 to 1 weight of anionic polymer bonded to 40 to 80 parts by weight of the ceramic beads and the surface of the ceramic beads with respect to 100 parts by weight of the filler composition. And 0 to 10 parts by weight of the neutral polymer.
Claims (6)
The polymer that can be used as the anionic polymer is a filler composition for skin filling using ceramic beads, characterized in that one of polyacrylic acid, polymethacrylic acid, polystyrene sulfonate, polyvinylsulfonate, hyaluronic acid, carboxymethylcellulose.
The filler composition for skin filling comprises ceramic beads comprising 40 to 80 parts by weight of ceramic beads and 0.001 to 1 part by weight of anionic polymer bonded to the surface of the ceramic beads, based on 100 parts by weight of the filler composition. Filler composition for skin filling using.
The ceramic bead filler composition for skin filling using ceramic beads, characterized in that the size of 25-100 micrometers.
The filler composition for skin filling includes 40 to 80 parts by weight of the ceramic beads, 0.001 to 1 part by weight of anionic polymer bonded to the surface of the ceramic bead, and 0 to 10 weight of neutral polymer, based on 100 parts by weight of the filler composition. Filler composition for skin filling using ceramic beads, characterized in that configured to include.
The neutral polymer is polyethylene glycol (PEG), polylactic glycolamide (polylactic glycolamide, PLGA), polyvinyl alcohol (polyvinyl alcohol, PVA), poloxamer (Polloxamer), characterized in that using ceramic beads Filler composition for skin filling.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020100057905A KR20110137907A (en) | 2010-06-18 | 2010-06-18 | Dermal filler using ceramic beads |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020100057905A KR20110137907A (en) | 2010-06-18 | 2010-06-18 | Dermal filler using ceramic beads |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20110137907A true KR20110137907A (en) | 2011-12-26 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020100057905A KR20110137907A (en) | 2010-06-18 | 2010-06-18 | Dermal filler using ceramic beads |
Country Status (1)
| Country | Link |
|---|---|
| KR (1) | KR20110137907A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101328495B1 (en) * | 2011-12-28 | 2013-11-13 | 전자부품연구원 | Anionic polymer surface-treated ceramic particle and method thereof |
| CN114668890A (en) * | 2022-03-28 | 2022-06-28 | 常州药物研究所有限公司 | Mixed gel containing calcium carbonate microspheres for injection and preparation method thereof |
| WO2023093532A1 (en) * | 2021-11-29 | 2023-06-01 | 爱美客技术发展股份有限公司 | Composite gel, preparation method, and application |
| EP4233926A2 (en) | 2016-09-07 | 2023-08-30 | Luminera Derm Ltd. | Methods of manufacturing injectable gels comprising cross-linked hyaluronic acid and hydroxyapatite |
-
2010
- 2010-06-18 KR KR1020100057905A patent/KR20110137907A/en not_active Application Discontinuation
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101328495B1 (en) * | 2011-12-28 | 2013-11-13 | 전자부품연구원 | Anionic polymer surface-treated ceramic particle and method thereof |
| EP4233926A2 (en) | 2016-09-07 | 2023-08-30 | Luminera Derm Ltd. | Methods of manufacturing injectable gels comprising cross-linked hyaluronic acid and hydroxyapatite |
| WO2023093532A1 (en) * | 2021-11-29 | 2023-06-01 | 爱美客技术发展股份有限公司 | Composite gel, preparation method, and application |
| CN114668890A (en) * | 2022-03-28 | 2022-06-28 | 常州药物研究所有限公司 | Mixed gel containing calcium carbonate microspheres for injection and preparation method thereof |
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