KR20110131855A - Atopic cosmetics with purple sweet potato extract - Google Patents

Abstract

PURPOSE: A cosmetic product containing purple sweet potato extract is provided to enhance antibacterial effect against Staphylococcus aureus. CONSTITUTION: A cosmetic and pharmaceutical composition for treating atopic dermatitis contains 0.001-10 wt% of purple sweet potato extract and 0.001-10 wt% of trichlosan. In an antibacterial ability test, the MIC(Minimum Inhibition Concentration) of triclosan and purple sweet potato extract is 0.3 ppm and 5 ppm, respectively. The MIC of a mixture of triclosan and purple sweet potato extract is 0.1 ppm.

Description

Atopic Cosmetics with Purple Sweet Potato Extract

The present invention relates to cosmetics for atopic dermatitis containing purple sweet potato extract, and more particularly, to a synergistic effect by containing triclosan and purple sweet potato together in the atopy-causing bacterium Stephylococcus aureus (Staphylococcus aureus) It is about the application to cosmetics, quasi-drugs, and pharmaceuticals.

There are many causes of atopic disease, such as imbalance of skin immune function and abnormalities of keratinocytes of skin, but there are still insufficient satisfactory safe therapeutic drugs. Agents that help skin barrier functions such as ceramides lack the effect, steroids, such as good effect, but causes many side effects such as addictive. Atopic disease is very sensitive to skin irritation, so the effect is important in the development of therapeutics, but careful study of the skin irritation is necessary.

In order to solve the problems described above, the present invention was developed to find a natural extract exhibiting antimicrobial activity against Stepilococcus aureus known as a causative bacterium for atopic diseases, and to search for a conventionally known triclosan and natural substances.

Stephylococcus aureus, the causative agent of atopic disease, was present in less than 30% of healthy skin, but more than 70% of atopic skin. Stepirococcus aureus is overproliferated compared to normal skin. Because of this, it was invented as Stepilococcus aureus as an atopic causative organism.

    The antimicrobial activity was tested on triclosan, which is used only in cosmetics with low skin irritation, and known synergistic effect against Stepirococcus aureus. Minimum Inhibition Concentration (MIC) was used to test the antimicrobial activity against S. aureus. As a result, triclosan and purple sweet potato extract used as antibacterial agents in cosmetics showed a synergistic effect, thereby completing the invention.

According to the present invention was found to have a synergistic effect when a combination of triclosan and purple sweet potato extract known to have a known antimicrobial activity against the atopy-causing bacteria Stepirococcus aureus, it relates to atopy cosmetics, quasi-drugs, pharmaceuticals .

Hereinafter will be described in detail for the practice in the present invention. The antimicrobial activity of the complex containing triclosan and purple sweet potato extract was 0.3 ppm and the MIC for triclosan was 0.3 ppm, and the MIC of purple sweet potato extract was measured. The MIC of the composite extract containing 5 ppm of triclosan and purple sweet potato extract showed a test result of 0.1 ppm.

   Table 1 is composed of cosmetics, quasi-drugs, and medicines containing triclosan and purple sweet potato extract. Comparative Example is a prescription of a typical cream or ointment, Example 1 is a prescription containing triclosan, an antimicrobial agent, Example 2 is a prescription containing a purple sweet potato extract, Example 3 is a prescription containing both triclosan and a purple sweet potato extract .

Comparative Example and Example order  Raw material  Comparative example  Example 1  Example 2  Example 3 One
2
3
4
5
6 Stearic acid
Cetostearyl alcohol
Liquid paraffin
Squalane
silicon
Purified water 3.0
2.5
12.0
1.0
1.0
To 100 3.0
2.5
12.0
1.0
1.0
To 100 3.0
2.5
12.0
1.0
1.0
To 100 3.0
2.5
12.0
1.0
1.0
To 100 7
8 Triclosan
Purple Sweet Potato Extract -
- 1.0
- -
1.0 1.0
1.0

   Next, as shown in Table 2, a panel test for atopic disease was conducted. To evaluate the atopy test by applying the comparative example and Examples 1, 2, 3 three times daily for 4 weeks in 25 groups of 100 persons (46 males, 64 females) composed of 1-10 years of severe atopic dermatitis. It was. Evaluation items were conducted by panel test through a questionnaire.

Panel test scale

100%: complete healing

 50%: fairly healed

 25%: Slightly improved

  0%: No inhibitory effect

Panel test Survey Average (%)  After 1 week  After 2 weeks  After 3 weeks  After 4 weeks  Comparative example   2.4   3.4   4.7   3.8  Example 1   37.4   48.4   52.4   62.6  Example 2   12.5   28.6   33.3   37.1  Example 3   68.2   74.5   89.6   97.4

As shown in the above results, it is shown that the formulation containing triclosan of Example 1 is more effective than the formulation containing purple sweet potato extract of Example 2. As shown in Example 3, it was found that the synergistic effect unexpectedly appeared when the triclosan and purple sweet potato extract at the same time.

Claims (1)

The anti-microbial mechanism of purple sweet potato extract for atopic disease contains 0.001% to 10% by weight and triclosan content of 0.001% to 10% by weight.