KR20110128961A - A composition using the oral cavity containing green tea extracts - Google Patents

Abstract

PURPOSE: An oral composition containing green tea extract is provided to suppress the growth of Streptococcus matans and to prevent dental plaque formation and dental caries. CONSTITUTION: An oral composition contains green tea extract. The composition also contains xylitol and sodium fluoride. The green tea extract is prepared by placing green tea leaves, stems, or flowers in 30% ethanol at 25°C for 4 days and filtering with a filter paper. The composition contains 0.02-1.0 wt% of the green tea extract, 0.02 wt% of sodium fluoride, 0.5-1.0 wt% of xylitol, and 0.05-1.0 wt% of malic acid.

Description

       A composition using the oral cavity containing Green Tea Extracts}

The present invention relates to a composition for oral cavity containing green tea extract, and more particularly, to inhibit the growth of Streptococcus matans, the main cause of tooth decay, and to react with impurities in the mouth and bacteria and green tea extract to form particles that form solidified reactions. It is to provide a composition for oral cavity.

Recently, as interest in oral hygiene increases, products related to oral care are becoming more and more diversified. Oral care products are usually intended for the removal of bad breath, the suppression of dental plaque formation or the prevention of tooth decay.

Bad breath is typically the result of volatile sulfur compounds (VSCs) produced by the breakdown of food debris deposited between the teeth and the periodontal sac by microorganisms. Plaque is produced by bacterial metabolism in the oral cavity. It is plaque formed by sugars and bacteria embedded in these polysaccharides. Because plaque is very sticky and not easily removed, it is usually the main cause of periodontal disease and tooth decay. In this regard, the addition of antimicrobial agents to oral cleaning products can be expected to be useful for removing bad breath, inhibiting plaque formation or preventing tooth decay.

Among many oral products, mouthwash is one of the popular consumer products because mouthwash aids in oral cleanliness and is convenient to use, and particularly useful for patients undergoing dental or cervical surgery.

For example, there is a Listerine-based mouthwash containing thymol as an active ingredient manufactured by Pfizer Pharmaceuticals. Timol has an antimicrobial effect because it can alter the cell wall of bacteria, but it causes tooth pigmentation and bitter taste, and it also causes side effects such as burning in the mouth.

Another common antimicrobial component in mouthwash products (eg day / night mouthwash) is chlorhexidine (CHX). Chlorhexidine adsorbs to the cell wall of bacteria at low concentrations and causes leakage of cytoplasm and shows bactericidal action. At high concentrations, chlorhexidine precipitates and aggregates the cell contents of bacteria and shows bactericidal action. However, products containing chlorhexidine have disadvantages such as pigmentation of teeth and tongue, bad taste, temporary taste disorders, temporary epithelial detaching and increased precipitation of tartar.

There are several microorganisms in the oral cavity such as Streptococcus mutans, Streptococcus sanguis, Streptococcus salivarius, Actinomyces viscous, Bacteroides gingvalis, and tooth decay is an infectious disease caused by microorganisms present in these oral cavity. In other words, when dextran produced by Streptococcus mutans forms a membrane on the tooth surface, sugar and bacteria attach to the plaque to form plaque, and the acid produced by the bacteria in the plaque desorbs the enamel surface of the tooth to advance tooth decay. As plaque further progresses to calculus, it causes periodontal diseases such as gingivitis, gingivitis, and alveolar pylori.

In order to suppress plaque formation and tooth decay, antibiotics or compounds such as fluoride, which inhibit the growth of S. mutans, have been suggested to be incorporated into oral products such as toothpaste and mouthwashes.

Among the decay inhibitors, antibiotics such as penicillin, erythromacin, and tetracycline have high side effects such as not only decay bacteria but also intestinal bacterial guns. There is a side effect of causing the back, and also attempts to suppress tooth decay with enzymes such as caries prevention vaccine or dextranase, but the effect is still unclear.

Fluorine, which is used as a typical anti-cavities compound, has the effect of inhibiting the growth of caries-causing bacteria, but even at very low concentrations, side effects (such as white spots on tooth enamel), strong toxicity and air pollution are severe.

As described above, although currently used mouthwashes have antibacterial effects, it can be seen that if they stay in the mouth for too long, it causes discomfort to patients and damages the oral mucosa. In addition, some of the chemicals contained in mouthwash products are harmful to humans over long periods of time. Moreover, if the content of ethanol in the mouthwash product is more than 25%, the product irritates the oral mucosa, and therefore it is not suitable for long-term use, especially for those with oral lesions. Therefore, there is a need for a mouthwash product that contains no harmful or irritating ingredients and is suitable for long-term use.

       It is an object of the present invention to provide an oral cleansing composition that can be frequently used by making edible plants and containing no ingredients irritating or harmful to the human body to improve conventional mouthwash products. By using a natural extract such as green tea extract to form a residue by reacting with bacteria in the oral cavity to provide a composition for oral cavity that can be identified with the naked eye to prevent oral diseases.

The present invention has been made to solve the above problems, the object of which is produced by Streptococcus matans, the main causative agent of caries in compounds such as antibiotics or fluoride to prevent the development of caries and inhibit the growth of S.mutans The present invention provides an oral composition containing green tea extract that can effectively prevent tooth decay by including green tea extract that inhibits the growth of dextran in oral products such as toothpaste or mouthwash. In addition, another object of the present invention is to inhibit the activity of the amylose and glucotransferases, caries-inducing enzymes to inhibit the formation of plaque to prevent demineralization of the enamel surface to the acid produced by bacteria in the plaque, due to tartar It is to provide a composition for oral cavity containing a protein oil that can prevent the periodontal disease, such as gingivitis, gingivitis, alveolar purpura.

In order to achieve the above object, the present invention provides a composition for oral cavity containing green tea extract. In another aspect, the present invention provides a composition for oral cavity, characterized in that the green tea extract and bacteria in the oral cavity reacts to produce residue.

As described above, the composition for oral cavity containing the green tea extract according to the present invention inhibits the growth of dextran produced by Streptococcus matans, the main causative agent of caries, and inhibits the decay enzymes amylase and glucotransparase. Caries can be effectively prevented by inhibiting the activity to inhibit the formation of plaque.

In addition, antibiotics or compounds such as fluoride, which prevent tooth decay and inhibit the growth of S. mutans, include green tea extracts in oral products such as toothpaste and mouthwashes. Demineralization of the surface of the enamel can be prevented, and periodontal diseases such as gingivitis, gingivitis, alveolar purpura caused by tartar can be prevented. In addition, green tea extract provides better antibacterial activity at the same concentration than tetracycline or erythromycin, which has the effect of inhibiting tooth decay bacteria, thereby inhibiting the adverse effects of human body caused by antibiotic abuse.

Therefore, the composition for oral cavity prepared by the present invention can provide an excellent bad breath removing effect over a long and short period of time, and can provide an excellent gum disease prevention effect, caries prevention effect and the like in the oral cavity.

      No drawing.

The composition for oral cavity of this invention contains green tea extract as a bactericidal and antimicrobial component.

In addition, the composition for oral cavity of the present invention contains xylitol and sodium fluoride as the composition for preventing gum disease in the composition.

Hereinafter, the preparation of the composition for oral cavity of the present invention will be described.

Green tea extract used in the present invention is as follows.

Green tea (Thea sinensis Linnaeus) is an evergreen tree or shrub belonging to Theaceae. Green tea is the second most widely consumed beverage after water, and its efficacy has long been studied. Green tea, black tea and oolong tea are produced from the leaves. The green tea is obtained by inactivating oxidation-related enzymes by vaporizing tea leaves, stems, or flowers, and keeping the polyphenol component stable. Polyphenols found in green tea are known as flavonols and catechins, and are known to have various effects such as antioxidant, anticancer, anti-inflammatory, and antibacterial properties.

Green tea extract used in the present invention is an extract obtained from green tea leaves, stems or flowers can be extracted by the following method. Soak green tea in 30% ethanol at 25 ℃ for 4 days, and then filtered using a filter paper to obtain a green tea extract.

In the composition for oral cavity of the present invention, the green tea extract obtained by the above method is 0.02 to 1.0% by weight relative to the total weight of the composition, 0.02% to sodium fluoride relative to the total weight, and 0.5 to 1.0% of xylitol relative to the total weight. It may further contain maleic acid in an amount of 0.05 to 1.0% by weight based on the total weight of the composition.

The composition for oral cavity of the present invention is excellent in antibacterial and bad breath reduction effect to inhibit the bacteria in the oral cavity by the synergistic effect of green tea extract, and provides a periodontal disease prevention effect by the convergence effect on the gum of malic acid.

The composition for oral cavity of this invention is not specifically limited in the formulation, Specifically, it may have formulations, such as a toothpaste, mouthwash, or mouthwash.

The compounding component of the composition for oral cavity used in the present invention is changed according to the use and type of the composition in addition to the green tea extract and xylitol, sodium fluoride described above.

Various oral compositions for carrying out the present invention may use a suitable component according to the type, for example, if the formulation is a toothpaste, as a conventional toothpaste components, abrasives, wetting agents, foaming agents, binders, sweeteners, pH adjusting agents, preservatives, It may contain an active ingredient, a fragrance, a brightener, a dye, a solvent and the like.

Examples of the abrasive include calcium carbonate, precipitated silica, aluminum hydroxide, calcium monohydrogen phosphate, and insoluble sodium metaphosphate. These abrasives may be used alone or in combination of two or more kinds thereof, preferably 1 to 60% by weight, preferably 10 to the total weight of the composition. 50 weight% is used.

As the humectant, glycerin, sorbitol solution, polyethylene glycol, propylene glycol, or the like is mixed alone or in combination of two or more, and 10 to 60% by weight, preferably 20 to 50% by weight, based on the total weight of the composition is used. As the foaming agent, anionic and nonionic surfactants such as sodium lauryl sulfate, sodium lauryl sarcosinate, sucrose fatty acid ester, polyoxyethylene hardened castor oil, and polyoxyethylene polyoxypropylene copolymer may be used alone or in combination of two or more thereof. 0.5 to 5% by weight, preferably 0.5 to 3% by weight, based on the total weight.

As the binder, carboxymethyl cellulose sodium, hydroxymethyl cellulose, carrageenan, xanthan gum, sodium alginate, etc. may be used alone or in combination of two or more thereof, and 0.1 to 5% by weight, preferably 0.1 to 2% by weight, based on the total weight of the composition is used. . As a sweetening agent, saccharin sodium, aspartame, stevioside, ziitol, and licorice may be used alone or in combination of two or more, and 0.05 to 5% by weight based on the total weight of the composition is used.

The pH adjusting agent includes sodium phosphate, disodium phosphate, trisodium phosphate, sodium pyrophosphate, citric acid, sodium citrate, tartaric acid, and the like, and preservatives such as methyl paraoxybenzoate, propyl paraoxybenzoate and sodium benzoate alone or two or more. Use by mixing.

The active ingredients include sodium fluoride, sodium monofluorophosphate, tin fluoride, chlorohexidine, allantoin chlorohydroxy aluminate, aminocaproic acid, tranexamic acid, triclosan, cetylpyridium chloride, zinc chloride, pyridoxine hydrochloride, acetic acid Tocopherol or the like may be used alone or in combination of two or more thereof.As a fragrance, peppermint oil, spearmint oil, menthol, and anetol may be mixed in an appropriate amount.Titanium oxide is used as a brightener, food coloring is used as a pigment, purified water and A solvent of ethanol is prepared according to a conventional toothpaste manufacturing method.

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Claims (1)

Oral composition containing green tea extract. In particular, green tea extract and oral bacteria and foreign substances react to solidify the composition is formed.

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