KR20110096468A - Dementia and degenerative brain disease prevention, treatment - Google Patents
Dementia and degenerative brain disease prevention, treatment Download PDFInfo
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- KR20110096468A KR20110096468A KR1020100016453A KR20100016453A KR20110096468A KR 20110096468 A KR20110096468 A KR 20110096468A KR 1020100016453 A KR1020100016453 A KR 1020100016453A KR 20100016453 A KR20100016453 A KR 20100016453A KR 20110096468 A KR20110096468 A KR 20110096468A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/90—Smilacaceae (Catbrier family), e.g. greenbrier or sarsaparilla
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
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Abstract
The present invention relates to the prevention and treatment of dementia and degenerative brain diseases. More specifically, the most serious cause of dementia and degenerative brain diseases is that as the age becomes older, the neurotransmitter dopamine is deficient. More brain due to lack of essential ingredients, lack of important hormones, accumulation of heavy metals (mercury, cadmium, lead), depletion of essential fatty acids in the brain, lack of oxygen in the brain, reduction of neurotransmitters such as aceticoline, and increased cholesterol Neuronal damage caused by the accumulation of toxic proteins (beta amyloid) in the genus has resulted in more dopamine deficiency.
Preventing and treating brain diseases such as degenerative brain disease, Alzheimer's, Parkinson's disease, senile dementia and cerebral infarction by solving the above problems.
By weight of main components, Tobokyeong root extract (Cheongmirae vine) 8-15%, ginseng extract 5-8%, licorice extract 17-20%, strong and poisonous extract 8-15%, purslane (jangmyeongchae) extract It is a composition consisting of 30-60%, Yin-Yang Extract 2-8%, Choseok Root Extract 7-12%, Ginger Extract 3-5%.
Aceticholine. Dopamine. Tobok Ryong. Vigor. Poisonous. purslane. Cornerstone
Description
The present invention relates to the prevention and treatment of dementia and degenerative brain diseases, in which the enzyme peroxidase is impaired as a cause of the onset factor, and the intracellular mitochondria supplying energy loses the function of removing oxygen free radicals to the brain due to the lack of dopamine. Beta-amyloid protein, a protein toxic substance, is caused by entanglement with nerve cells and destruction of neural circuits of brain cells. Prevention and treatment of the present invention The present invention provides aceticoline and dopamine, O-3, saponin, alkaloids, flavonoids, vitamins C, D, E and sex for the release of toxic proteins in the brain and the protection and memory of nerve cells. It supplies hormone-promoting substances, releases heavy metals accumulated in the brain, and releases triglycerides or cholesterol, lowers blood pressure, affects blood sugar and anti-oxidation, such as fagins disease, degenerative brain diseases, Alzheimer's disease, cerebral infarction, elderly dementia, forgetfulness, This product prevents and treats dizziness.
Although there are products that use ginseng, ginseng has the effect of increasing the activity of corticosteroids (ACTH) in the brain and ingredients that inhibit memory loss, but the effect is insufficient and the drug is short.
For fundamental treatment of dementia
① to activate the brain, memory to help choline ingredients should be. Choline penetrates the brain barrier, creating biochemicals that help memory, and acts to calm nerves by acting on signals from the brain to restore memory.
② As the age of the neurotransmitter, which reduces the deficiency of dopamine should be replenished.
③ beta amyloid, a toxic protein accumulated in the brain, should be removed and discharged.
④ Saponin, alkaloids, flavonoids, germanium, sex hormone secretion promoting supplies to suppress memory loss function.
⑤ The brain is composed mostly of essential fatty acids, O-3, rich in essential fatty acids other than easy to supply, vitamin C, D, E components and abundant minerals should be supplied to strengthen the immune system against brain diseases.
① Loss of memory due to accumulation of toxic protein beta amyloid in the brain, activated by acetic choline
② Pagins disease develops when 80% of dopamine, a brain neurotransmitter, is deficient, and 50% of dopamine in the brain is naturally extinguished at 50-60 years of age, providing pre-deficiency to strengthen immunity to brain diseases. .
③ Promotes the effects of sex hormone secretion, saponin, alkaloids, flavonoids, and germanium, which are effective in cognitive ability of the brain, strengthening the immunity of mitochondria to supply brain cells with energy.
④ The toxic proteins and heavy metals accumulated in the brain should be discharged quickly and the minerals other than O-3, vitamin C, E, and D should be supplied for the activation of the brain.
① Tobok-Ryong Root (Chinese vine root) contains 4% saponin, and saponins of ginseng are Silla A, B, and C. Silla saponin B is enzymatically decomposed into 2 molecules of glucose and 1 molecule of ramose. Diosgene becomes diosgenin and two-molecules of lamnose when it breaks down water. Diosgenin is used as a synthetic material of steroid hormones. It is effective in lowering arterial pressure, treating cholesteric atherosclerosis, radiation resistance and mercury poisoning. It is a component that increases the activity of corticosteroids (ACTH).
② Purslane (Jangmyeongchae) contains aceticholine, dopamine and O-3 components of 300-400 mg per 100g, it treats Alzheimer's and Parkin's disease and releases cholesterol and antioxidants.
③ Curcumin and oleic acid among ginger, strong and poisonous ingredients are effective in degenerative brain disease, Alzheimer's disease, and dementia caused by toxic proteins (beta) that are accumulated in the brain to protect nerve cells from damage.
④ Ginger ingredient removes toxicity, sterilizes, facilitates peripheral blood vessels and blood circulation, and in combination with other medicines, promotes rapid therapeutic effect and the secretion of a hormone called nephthine, which breaks down body fat, thereby preventing blood clots and lowering cholesterol. .
⑤ Yin and Yang ingredients are alkaloids, flavonoids, saponins, especially epimedin components promote sex hormone secretion.
⑥ transit sleep ingredients are saponin, flavonoids, alkaloids and blood to clear the blood to activate the brain and help choline to prevent Parkinson's disease, senile dementia, cerebral infarction, and improve brain power.
① toxic protein excretion in the brain and neuronal damage protection
② Aceticholine necessary for memory loss activates memory
③ supplements dopamine, a neurotransmitter deficient in toxic proteins.
④ supplement the germanium to remove the free radicals caused by dysfunction in brain cells.
⑤ The components of the brain, essential fatty acids O-3, sex hormone secretagogues, saponins, alkaloids, flavonoids, vitamins C, D, E and abundant minerals to supply memory to inhibit memory function and activate the immune system.
⑥ The toxic proteins and heavy metals accumulated in the brain are discharged into the body, and cholesterol recovery and blood loss are quickly restored by the brain.
Each component is washed, shredded and pulverized. The water is added 5-15 times by weight, preferably 10 times of water, and extracted by heating at 80-100 ° C. (optimal 90-95 ° C.) for 4-6 hours, followed by filtration. Extracts can be prepared or methanol or ethanol can be selected as a solvent, and the organic filtrate can be prepared by concentrating the filtrate obtained by filtration after aging for 3-7 days at room temperature with 20-30% alcohol water of the extraction solvent. Can be.
However, Tobokryong is echoed in water for 3-4 days to remove constipation symptoms, and extract is used only in the ground part, and the roots of the corner stone are slightly blanched and dried before use.
In the extraction method, the extraction process may be repeated two or more times as necessary, and the extract obtained after filtration may be made into a powder form by distilling under reduced pressure.
If you look at the components by weight
Tobokyeong extract 8-15%, ginseng extract 5-8%, licorice extract 17-20%, vigorous, poisonous extract 8-15%, purslane extract 30-60%, Yin Yang Guk extract 2-8%, salt leaf root extract 7-12%, ginger extract 3-5%.
Changes in Beta Amyloid Reduction According to Choline Dosage
Change according to input amount by raw material
It is a cause-specific treatment for dementia and degenerative brain diseases, supplements the deficiency of dopamine, a neurotransmitter of the brain itself, and supplies the nutrients necessary for the brain to activate the brain's own immunity and to help recover from memory loss. By supplying saponins, alkaloids, sex hormone secretagogues, germanium, flavonoids, etc., the present invention is effective for brain disease, forgetfulness, dizziness, cerebral infarction, gout as well as dementia.
It also releases toxic proteins and heavy metals, removes triglycerides and cholesterol, lowers blood pressure due to brain stasis, and absorbs aceticholine even when memory loss due to neuronal blockage occurs. It is a product that can be quickly recovered.
[ Diagram ]
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| Application Number | Priority Date | Filing Date | Title |
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| KR1020100016453A KR20110096468A (en) | 2010-02-22 | 2010-02-22 | Dementia and degenerative brain disease prevention, treatment |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020100016453A KR20110096468A (en) | 2010-02-22 | 2010-02-22 | Dementia and degenerative brain disease prevention, treatment |
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| KR20110096468A true KR20110096468A (en) | 2011-08-30 |
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| KR1020100016453A KR20110096468A (en) | 2010-02-22 | 2010-02-22 | Dementia and degenerative brain disease prevention, treatment |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103070893A (en) * | 2013-01-10 | 2013-05-01 | 济南康众医药科技开发有限公司 | Medicine prepared by purslane and used for treating senile dementia |
| CN107115434A (en) * | 2017-04-07 | 2017-09-01 | 贵州神奇老年病研究院 | It is a kind of to treat medicine of senile dementia and preparation method thereof |
| KR20180064070A (en) | 2016-12-05 | 2018-06-14 | 광주대학교산학협력단 | Antioxidative castella composition comprising Aster scaber Thunb and stachys sieboldii |
| KR20200025052A (en) * | 2018-08-29 | 2020-03-10 | 건국대학교 산학협력단 | Composition for inhibiting neurotoxicity comprising gintonin-enriched fraction as an active ingredient |
-
2010
- 2010-02-22 KR KR1020100016453A patent/KR20110096468A/en not_active Application Discontinuation
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103070893A (en) * | 2013-01-10 | 2013-05-01 | 济南康众医药科技开发有限公司 | Medicine prepared by purslane and used for treating senile dementia |
| KR20180064070A (en) | 2016-12-05 | 2018-06-14 | 광주대학교산학협력단 | Antioxidative castella composition comprising Aster scaber Thunb and stachys sieboldii |
| CN107115434A (en) * | 2017-04-07 | 2017-09-01 | 贵州神奇老年病研究院 | It is a kind of to treat medicine of senile dementia and preparation method thereof |
| KR20200025052A (en) * | 2018-08-29 | 2020-03-10 | 건국대학교 산학협력단 | Composition for inhibiting neurotoxicity comprising gintonin-enriched fraction as an active ingredient |
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