KR20110081807A - 갑상선암의 위험도 평가를 위해 유용한 유전적 변이 - Google Patents

갑상선암의 위험도 평가를 위해 유용한 유전적 변이 Download PDF

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KR20110081807A
KR20110081807A KR1020117005803A KR20117005803A KR20110081807A KR 20110081807 A KR20110081807 A KR 20110081807A KR 1020117005803 A KR1020117005803 A KR 1020117005803A KR 20117005803 A KR20117005803 A KR 20117005803A KR 20110081807 A KR20110081807 A KR 20110081807A
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thyroid cancer
risk
alleles
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율리우스 구드문트쏭
다니엘 구드뱌르쏭
파트리끄 쉴럼
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디코드 제네틱스 이에이치에프
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/73—Expression systems using phage (lambda) regulatory sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/046—Thyroid disorders
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
KR1020117005803A 2008-08-12 2009-08-12 갑상선암의 위험도 평가를 위해 유용한 유전적 변이 Ceased KR20110081807A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IS8755 2008-08-12
IS8755 2008-08-12
IS8791 2009-02-05
IS8791 2009-02-05

Publications (1)

Publication Number Publication Date
KR20110081807A true KR20110081807A (ko) 2011-07-14

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KR1020117005803A Ceased KR20110081807A (ko) 2008-08-12 2009-08-12 갑상선암의 위험도 평가를 위해 유용한 유전적 변이

Country Status (10)

Country Link
US (1) US20110230366A1 (enExample)
EP (1) EP2334820A1 (enExample)
JP (1) JP2011530306A (enExample)
KR (1) KR20110081807A (enExample)
CN (1) CN102177252B (enExample)
AU (1) AU2009280807A1 (enExample)
CA (1) CA2733910A1 (enExample)
IL (1) IL211177A0 (enExample)
NZ (1) NZ591613A (enExample)
WO (1) WO2010018600A1 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20160051079A (ko) * 2014-10-31 2016-05-11 에스케이텔레콤 주식회사 갑상선암의 서브타입 분류용 조성물
KR20190013240A (ko) * 2017-08-01 2019-02-11 사회복지법인 삼성생명공익재단 Ahr 분류에 기반한 갑상선암 예후 예측 방법 및 시스템
KR20190077997A (ko) * 2017-12-26 2019-07-04 주식회사 클리노믹스 질병 및 표현형 위험도 예측 장치 및 방법
WO2021132920A1 (ko) * 2019-12-27 2021-07-01 주식회사 클리노믹스 유전자 검사를 위한 맞춤형 유전자칩 및 이의 제작 방법

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10236078B2 (en) 2008-11-17 2019-03-19 Veracyte, Inc. Methods for processing or analyzing a sample of thyroid tissue
US9495515B1 (en) 2009-12-09 2016-11-15 Veracyte, Inc. Algorithms for disease diagnostics
EP2385989A4 (en) * 2008-11-26 2012-04-25 Decode Genetics Ehf GENETIC VARIANTS FOR THE RISK ASSESSMENT OF THYROID CANCER
JP6078339B2 (ja) 2009-05-07 2017-02-08 ベラサイト インコーポレイテッド 甲状腺状態の診断のための方法および組成物
US20140087961A1 (en) * 2011-03-17 2014-03-27 Illumina Inc. Genetic variants useful for risk assessment of thyroid cancer
US8718950B2 (en) 2011-07-08 2014-05-06 The Medical College Of Wisconsin, Inc. Methods and apparatus for identification of disease associated mutations
WO2013088457A1 (en) * 2011-12-13 2013-06-20 Decode Genetics Ehf Genetic variants useful for risk assessment of thyroid cancer
EP2925886B1 (en) * 2012-11-27 2019-04-24 Pontificia Universidad Católica de Chile Compositions and methods for diagnosing thyroid tumors
US11976329B2 (en) 2013-03-15 2024-05-07 Veracyte, Inc. Methods and systems for detecting usual interstitial pneumonia
EP3770274A1 (en) 2014-11-05 2021-01-27 Veracyte, Inc. Systems and methods of diagnosing idiopathic pulmonary fibrosis on transbronchial biopsies using machine learning and high dimensional transcriptional data
GB201504607D0 (en) * 2015-03-18 2015-05-06 Patia Biopharma S A De C V Methods,tools and systems for the assessment,preventation,management and treatment selection for type 2 diabetes
US10424396B2 (en) * 2015-03-27 2019-09-24 Sentieon Inc. Computation pipeline of location-dependent variant calls
US10395759B2 (en) 2015-05-18 2019-08-27 Regeneron Pharmaceuticals, Inc. Methods and systems for copy number variant detection
CN109074426B (zh) 2016-02-12 2022-07-26 瑞泽恩制药公司 用于检测异常核型的方法和系统
CN106636413B (zh) * 2016-12-28 2019-07-16 常州市第二人民医院 一种用于诊断哮喘的分子标志物
US11217329B1 (en) 2017-06-23 2022-01-04 Veracyte, Inc. Methods and systems for determining biological sample integrity
CN107194206A (zh) * 2017-06-26 2017-09-22 思畅信息科技（上海）有限公司 一种基于大数据的染色体异常位点的筛选方法
CN108315425B (zh) * 2018-04-10 2021-08-06 广东省人民医院(广东省医学科学院) 甲状腺癌转移相关基因检测用的pcr特异性引物、试剂盒及其使用方法
EP3935581A4 (en) 2019-03-04 2022-11-30 Iocurrents, Inc. DATA COMPRESSION AND COMMUNICATION USING MACHINE LEARNING
CN114694836B (zh) * 2020-12-30 2024-06-04 上海交通大学医学院附属瑞金医院 基于甲状腺癌淋巴结转移预测模型的评估系统

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4376110A (en) * 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US5700637A (en) * 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
US6054270A (en) * 1988-05-03 2000-04-25 Oxford Gene Technology Limited Analying polynucleotide sequences
US5223409A (en) * 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5744101A (en) * 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5288644A (en) * 1990-04-04 1994-02-22 The Rockefeller University Instrument and method for the sequencing of genome
EP0695941B1 (en) * 1994-06-08 2002-07-31 Affymetrix, Inc. Method and apparatus for packaging a chip
US6287850B1 (en) * 1995-06-07 2001-09-11 Affymetrix, Inc. Bioarray chip reaction apparatus and its manufacture
US6300063B1 (en) * 1995-11-29 2001-10-09 Affymetrix, Inc. Polymorphism detection
EP2369007B1 (en) * 1996-05-29 2015-07-29 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
US6429027B1 (en) * 1998-12-28 2002-08-06 Illumina, Inc. Composite arrays utilizing microspheres
US20020077775A1 (en) * 2000-05-25 2002-06-20 Schork Nicholas J. Methods of DNA marker-based genetic analysis using estimated haplotype frequencies and uses thereof
JP4729030B2 (ja) * 2002-07-31 2011-07-20 株式会社東芝 塩基配列検出装置
JP4994676B2 (ja) * 2006-02-27 2012-08-08 富士通株式会社 遺伝子多型解析支援プログラム、該プログラムを記録した記録媒体、遺伝子多型解析支援装置、および遺伝子多型解析支援方法
CN101608227A (zh) * 2008-06-20 2009-12-23 上海主健生物工程有限公司 甲状腺癌遗传检测试剂盒

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20160051079A (ko) * 2014-10-31 2016-05-11 에스케이텔레콤 주식회사 갑상선암의 서브타입 분류용 조성물
KR20190013240A (ko) * 2017-08-01 2019-02-11 사회복지법인 삼성생명공익재단 Ahr 분류에 기반한 갑상선암 예후 예측 방법 및 시스템
KR20190077997A (ko) * 2017-12-26 2019-07-04 주식회사 클리노믹스 질병 및 표현형 위험도 예측 장치 및 방법
WO2021132920A1 (ko) * 2019-12-27 2021-07-01 주식회사 클리노믹스 유전자 검사를 위한 맞춤형 유전자칩 및 이의 제작 방법

Also Published As

Publication number Publication date
US20110230366A1 (en) 2011-09-22
CA2733910A1 (en) 2010-02-18
EP2334820A1 (en) 2011-06-22
IL211177A0 (en) 2011-04-28
WO2010018600A1 (en) 2010-02-18
JP2011530306A (ja) 2011-12-22
AU2009280807A1 (en) 2010-02-18
CN102177252A (zh) 2011-09-07
NZ591613A (en) 2013-01-25
CN102177252B (zh) 2014-12-24

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