KR20110038386A - Pharmaceutical composition comprising extract of pulsatilla koreana for alalgesic - Google Patents
Pharmaceutical composition comprising extract of pulsatilla koreana for alalgesic Download PDFInfo
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- KR20110038386A KR20110038386A KR1020090095656A KR20090095656A KR20110038386A KR 20110038386 A KR20110038386 A KR 20110038386A KR 1020090095656 A KR1020090095656 A KR 1020090095656A KR 20090095656 A KR20090095656 A KR 20090095656A KR 20110038386 A KR20110038386 A KR 20110038386A
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- South Korea
- Prior art keywords
- extract
- pain
- composition
- analgesic
- pasqueflower
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
Currently, as analgesics, anti-inflammatory drugs such as aspirin and tylenol are the mainstream, and in case of severe pain, morphine drugs are mostly used. Recently, a new pain inhibitor is being developed. In this case, the drug developer, Javelin Pharmaceuticals' intranasal morphine spray lylomine, has a pain relief effect comparable to that of intravenous morphine in the treatment of moderate to severe postoperative pain in
In Korea, Germany developed a capsaicin antagonist, and in February 2004, Schwarz Pharma, a German multinational pharmaceutical company, recognized the value and signed a joint research and licensing agreement. There have been no attempts to develop or attempt pain relief using bee-flavored flowers.
As the society ages, as well as chronic malignant neoplastic pain, patients with degenerative arthritis and low back pain are increasing every year. However, existing opiates such as morphine have limited use due to narcotic action and the pain itself is a disease. The demand for pain relievers is expected to be much higher in the future, and the development of painkillers for pain that does not respond to existing painkillers is in high demand and existing narcotic and non-narcotic painkillers There are many reports of pain patients who do not respond to them, and existing opioids, which are known to have relatively high analgesic effects, cannot be used conveniently by general patients due to narcotic and serious side effects. Develop natural resources with new analgesic effects I would like to.
The present invention relates to an analgesic composition comprising an extract of a pasqueflower, showing the superior analgesic effect, and then performing a test on various indicators for various pains.
To date, as analgesics, acetaminophen, aspirin, etc. have been used, but they should be administered to adults at high doses of about 1 g to 4 g per day, which causes side effects such as gastrointestinal disorders, allergies, and liver toxicity. Accordingly, there is an urgent need for the development of new analgesic agents having excellent analgesic effects even at low doses without side effects.
Pulsatilla koreana is a perennial herb that grows around 40cm in height and grows in dry open grassland. Flowers bloom reddish purple in April-May. Fruits are covered with white hairs. They are used as medicine for headache, edema, dysentery, heart disease, mucus, gastritis. In particular, it is known to have a remarkable effect on the treatment of brain diseases. If you use legumes properly, you can fix various cancers, including brain tumors. There have been some studies on the roots of pasqueflower, but there have been no studies on the analgesic efficacy of the extracts from the ground.
It is an object of the present invention to provide an analgesic composition having excellent analgesic effect including pasqueflower extract and the same.
The analgesic effect is measured through the riding inhibition test, formalin test, substance P pain test, and tail-flick test using pasqueflower extract.
The present invention is characterized by obtaining the analgesic effect using the pasqueflower extract, which is excessive in the analgesic composition, which is meaningful in terms of the analgesic composition derived from natural products, and when used actively, it can be widely used as an analgesic composition for various diseases. Can and further contribute to national health.
Beetle odor extract of the present invention is added to
The present invention is described in more detail based on the following examples, but the present invention is not limited thereto.
Sample Preparation Example : The pasqueflower extract of the present invention is added with
The present invention is described in more detail based on the following examples, but the present invention is not limited thereto.
Example 1: Of Pasqueflower Extract Riding ( writhing Suppression test
The pasqueflower extract obtained from the preparation example was orally administered to 4 week old ICR mice (about 25 g body weight) in an amount of 200 mg / kg. Subsequently, 0.25% of 1% acetic acid was administered to the abdominal cavity of the mice, and the riding response was examined for 30 minutes. In this case, the same test was performed using mice that did not receive the natural product (half-flower) as a control.
1 is a graph showing the number of riding according to the administration of the pasqueflower extract. As shown in Figure 1, the natural product (half-flower) inhibits the riding reaction by acetic acid.
Example 2: Substance P Pain Test of Pasqueflower Extract
The pasqueflower extract obtained from the preparation example was orally administered to 4 week old ICR mice (about 25 g in weight) in an amount of 200 /. After 30 minutes, the amount of substance P (Substance P) was administered to the intrathecal of each mouse in an amount of 0.7, and the mice had pain reactions such as licking or shaking the soles for 30 minutes. Measured. In this case, the same test was performed using mice that did not receive the natural product (half-flower) as a control.
Figure 2 shows the pain period (seconds) of the mice according to the administration of the pasqueflower extract. As shown in Figure 2, the pasqueflower extract extracts the pain response by substance P.
Example 3: the hot bottom examination of pasqueflower extract of aerial parts (Hot - plate test )
The pasqueflower extract obtained from the preparation example was orally administered to 4 week old ICR mice (about 25 g in weight) in an amount of 200 /. The duration of labor (seconds) was then determined by placing each mouse on a hot floor at 55 degrees C and then measuring the time for the plantar movement response to pain due to this thermal nociceptor stimulus. This test confirms the analgesic effect of the drug on the peripheral to central circuit. At this time, the same test was performed using the mice that were not administered the palate flower extract as a control.
Figure 3 shows the duration of labor (seconds) over time after placing the mouse administered with 200 mg / kg pasqueflower ground extract on the hot floor. As shown in FIG. 3, pasqueflower ground extract increases the analgesic time tolerated at the hot bottom.
1 is a graph showing the number of riding according to the administration of the pasqueflower extract.
Figure 2 is a graph showing the pain period (seconds) of the mouse according to the administration of the pasqueflower extract.
Figure 3 is a graph showing the duration of labor (seconds) over time after placing a mouse administered with 200 mg / kg of pasqueflower ground extract on a hot floor.
Claims (6)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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KR1020090095656A KR20110038386A (en) | 2009-10-08 | 2009-10-08 | Pharmaceutical composition comprising extract of pulsatilla koreana for alalgesic |
Applications Claiming Priority (1)
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KR1020090095656A KR20110038386A (en) | 2009-10-08 | 2009-10-08 | Pharmaceutical composition comprising extract of pulsatilla koreana for alalgesic |
Publications (1)
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KR20110038386A true KR20110038386A (en) | 2011-04-14 |
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KR1020090095656A KR20110038386A (en) | 2009-10-08 | 2009-10-08 | Pharmaceutical composition comprising extract of pulsatilla koreana for alalgesic |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103272006A (en) * | 2013-05-31 | 2013-09-04 | 上海师范大学 | Preparation method for pulsatilla chinensis regel extracting solution and application of pulsatilla chinensis regel extracting solution |
CN104922552A (en) * | 2015-06-30 | 2015-09-23 | 孙霞 | Traditional Chinese medicine for treating postpartum abdominal pain |
-
2009
- 2009-10-08 KR KR1020090095656A patent/KR20110038386A/en not_active Application Discontinuation
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103272006A (en) * | 2013-05-31 | 2013-09-04 | 上海师范大学 | Preparation method for pulsatilla chinensis regel extracting solution and application of pulsatilla chinensis regel extracting solution |
CN104922552A (en) * | 2015-06-30 | 2015-09-23 | 孙霞 | Traditional Chinese medicine for treating postpartum abdominal pain |
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