KR20100090986A - Stent an internal decomposition anger hook - Google Patents

Abstract

PURPOSE: A biodegradable hook stent is provided to prevent the thrombosis of various internal organs and the disassembly of the hook stent through a hooking action and to enable a user to easily eliminate the hook stent due to the biodegradable properties. CONSTITUTION: A biodegradable hook stent includes: a plurality of bile outlet holes which discharge the bile; a drainage tube body which has bile outlet holes; a hanging piece which is projected from the upper and lower parts of the drainage tube body; a bile duct which is connected to the liver and duodenum among the blood vessels or internal organs; a hanging device(10) which meets the inner sidewall of the bile duct not to be downwardly escaped and consists of biodegradable polymer substances which can be dissolved into body fluid; and a drainage tube(20) which is removably inserted into the hanging device and induces the bile to the duodenum.

Description

Stent an internal decomposition anger hook}

The present invention relates to a stent, and in particular, inflammation occurs after endoscopic procedures of various human organs and organs such as the biliary tract, esophagus, airways, and ureters in the body to prevent the passage of the blockage, and biodegradation that melts and disappears after a certain period of time due to body fluids. The present invention relates to a degradable hook stent in a body in which a polymer is made of a component and is dissolved by body fluids, thereby causing a loss of locking action, and thus no side effects occur during the removal procedure.

In general, due to the narrowing of the ducts and lesions occurring in various organs such as biliary tract, esophagus, airway, and ureters, the trachea of the organs is narrowed or wounds generated when treating the lesion site using endoscopy into the human body. Various stents are used to widen the passage of organs that have problems such as temporary inflammation and narrowing of organ passages.

Such stents have been widely used in the development of modern medicine for use in Endoscopic Retrograde Biliary Drainage (ERBD) or Endoscopic Retrograde Pancreatic Drainage (ERPD).

Here, the drainage of the bile ducts includes a method of puncturing the bile ducts directly and a method using an endoscope. Endoscopic Biliary Drainage (EBD) is used for endoscopic pancreas and cholangiopancreatography (ERCP). Biliary drainage is an important treatment along with endoscopic papillary sphincter incision (EST) in the treatment of obstructive jaundice.It is divided into bile duct drainage, which drains the bile into the duodenum by using bile duct drainage, which is drained externally through the nasal bile duct, and stents. .

In addition, bile duct drainage is a procedure for securing obstructive jaundice by installing a stent in the stenosis area using an endoscope for the purpose of decompression of papillary tumor patients or patients who have failed to remove the bile duct stones. It can be applied to all patients, but it is a treatment that adapts to malignant obstructive diseases, especially located in the papilla, distal biliary tract and liver. This procedure is based on the premise of cholangiopancreatography and papillary sphincter incision (EST). It is an important drainage method along with transdermal bile duct drainage (PTBD) for the evaluation and treatment of liver and biliary tract obstruction.

On the other hand, pancreatitis is one of the most common complications caused by a number of factors, such as physical damage, chemical damage, infection, hypersensitivity reactions, heat damage, etc. It is damaged by the cause. In most cases, the incidence of papillary damage during intubation is the main cause of prolonged intubation, which leads to contraction of the zygomatic sphincter and swelling of the papilla, causing pancreatitis.

In addition, in patients with sphincter of Oddi Dysfunction (SOD), the incidence of pancreatitis after papillary sphinctomy surgery increases as well as the incidence of mortality and papillary stenosis. For this reason, we recommend temporary pancreatic drainage to the pancreatic duct in high-risk groups, prolonged intubation times, repeated intubation, or papillary sphinctomy in cases of udicum sphincter disorders, and endoscopic resection of papillary tumors. If the diameter is thin, it can be inserted into the pancreatic duct without papillary sphinctomy.)

In particular, the internal flow method has a disadvantage in that the drainage maintenance period is shorter than the external flow method, and the drainage conduit cannot be cleaned, and the drainage conduit is difficult to replace. The drainage tube used for bile duct drainage is made of tefron, polyethylene, polyurethane, etc., and has a diameter of 7 to 12F, and has multiple side holes to facilitate bile drainage. .

In addition, the endurance method has the advantage of draining bile into the duodenum, there is no loss of body fluids and electrolytes, and there is no problem in digestive absorption, but the biggest problem is that the drainage tube is easily blocked. Of course, the larger the diameter of the drainage tube, the longer the retention period of the drainage tube, but this increases the likelihood of reflux of the duodenal contents and cholangitis. Therefore, the development of a metallic stent such as a gianturco-Rosch Z-drain tube, a wall stent, and a strecker stent, which can secure a wide lumen above 15F due to a small diameter at the time of insertion and expansion after insertion, has been increasing.

A typical example of a conventional stent for performing such bile duct drainage and pancreatic drainage is shown in FIGS. 1A and 1B.

This, the conventional stent is configured to project the upper and lower engaging pieces (3a, 3b) corresponding to the upper and lower portions of the drainage tube body (2) in which a plurality of bile discharge holes (1) through which bile is discharged.

As such, the conventional stent is inserted from the outside of the human body in a state connected to the end of a separate endoscope for insertion, the upper catching piece (3a) is bent by the elastic force during insertion is moved by the narrowing due to inflammation Located at the upper part of the generated lesion, the lower hook piece 3b is inserted into the bile duct 6 and supported, and when the procedure is completed, bile secreted from the liver 4 flows into the bile duct 6 and then drains the body ( It is used to digest food by supplying to the duodenum (5) while being flowed and discharged through the hollow inner and bile discharge holes (1) of 2).

However, the conventional stent should check the recovery and narrowing of the inflammation in the bile ducts periodically after the procedure is completed, and when the recovery is completed, the stent removal procedure must be performed using the endoscope used in the procedure.

As shown in Figure 2a and Figure 2, the conventional stent is removed by removing the stent to the lower direction of the bile duct when performing the removal procedure, the upper locking piece is caught on the inner wall surface of the bile duct is drawn out with excessive force If you do, there is a problem that can cause injury to the inner wall of the bile ducts.

In addition, the conventional stent requires a very careful removal procedure in order not to cause a wound on the inner wall of the bile duct, so that the procedure is very difficult and there is a problem of recurrence of inflammation due to infection when a wound occurs.

Due to this, it does not escape in the bile ducts and induces a smooth flow of bile, and the fasteners for support are made of a material that can be decomposed in the human body, so that the locking function is lost after a certain period of time, so that the removal procedure for removal is easy. Therefore, there is an urgent need for improved stents that can fundamentally prevent the development of secondary wounds or inflammation.

Accordingly, the present invention is made in view of the problems of the prior art as described above to prevent the blockage of various organs such as biliary tract, esophagus, airway and ureter due to inflammation caused by the wound generated after the endoscopy, body fluid It is an object of the present invention to provide a decomposable hook stent in the body that is easily removed by being decomposed and destroyed by body fluid while preventing the detachment by a locking action to smoothly flow.

In addition, another object of the present invention can be easily combined with the latch to perform the expansion of the pipeline, the role of engaging and bodily fluid induction in the organ, and the drainage pipe to perform the expansion and induction of the duct can be easily separated from the hanger To lose.

In addition, another object of the present invention is that the fastener is a biodegradable polymer as a component of the human body in the body by the body of the body by the decomposed and extinguished the jam piece by the loss of the locking action is easy to remove the procedure so as not to cause secondary wounds in the bile duct wall There is.

In addition, another object of the present invention is to provide a locking function in both directions as needed by combining the locking holes on both ends of the drain pipe.

In order to achieve the above object, the present invention is formed in the upper and lower portions of the drainage tube body formed with a plurality of bile discharge holes through which bile is discharged so as to protrude, so that the bile duct connecting the liver and duodenum of blood vessels or organs in the body after the endoscopy In the stent to be inserted into the bile ducts to prevent clogging by the lesion to induce smooth flow of bile, the stent to be in contact with the inner wall surface of the bile ducts to be prevented from falling downward and to dissolve by melting into body fluids, It is detachably inserted into the inside and consists of a drainage tube leading the bile into the duodenum; When the healing of lesions in the bile ducts is completed, the locking mechanism is melted and the locking action is lost, thereby providing a decomposable hook stent in the body, characterized in that it is configured to simplify the removal procedure.

As described above, the present invention prevents the blockage of various organs such as the biliary tract, esophagus, airway, and ureter due to the inflammation caused by the wound generated after the endoscopy, and ensures the fluidity and smooth escape of body fluids. Decomposition into body fluids, the locking function is lost, the removal procedure is easy to reduce the pain and economic burden of the patient.

In addition, it is possible to simplify the management aspect by separating and engaging the expansion port, the locking role and the fluid induction in the organ, and the drainage pipe for performing the expansion and induction role to the hanging hole in the organ.

In addition, since the hanger is made of biodegradable polymer and decomposed in a harmless state to the human body, the hanger is lost during the removal procedure to remove the hanger, and can be easily performed. have.

In addition, it is possible to provide a locking function in both directions as needed by combining the locking holes on both ends of the drainage tube, there is an effect to prevent the departure from the initial position even in the excessive movement of the patient.

BRIEF DESCRIPTION OF THE DRAWINGS The above and other features and advantages of the present invention will be more apparent from the following detailed description taken in conjunction with the accompanying drawings, in which: FIG.

As shown in Figures 3a and 4a, the decomposable hook stent of the present invention is that the bile duct 6, which connects the liver 4 and the duodenum 5 of blood vessels or organs in the body, is blocked by the lesion after the endoscopy. It is inserted into the bile duct 6 to prevent the stent (100, 200, 300) is configured to induce a smooth flow of bile.

As shown in Figure 3a to 3c, the stent 100 is to be used for the procedure of bile duct drainage or pancreatic drainage, in the present invention will be described for example by the bile duct drainage, the inside of the bile duct 6 It is composed of a drainage tube 20 which is connected to the locking hole 10, which is fixed to the hook 10, the bile flows to the duodenum (5).

First, the catch 10 is fastened to the inner wall surface of the bile duct 6 is prevented from being separated from the upper direction and is composed of a biodegradable polymer is made of a component so that it can be dissolved by dissolving into body fluids.

In addition, the biodegradable polymer of the latch 10 is poly l-lactic acid (PLLA), poly lactic acid (PLA), polyglycolic acid (PGA), poly glycolide-co-L- lactide acid (PGLA) Polydioxanone) and PGCL (Poly glycolide-co-caprolactone) are selected from one or two or more selected from each other.

Such, the locking hole 10 has a plurality of locking pieces 12 that can be caught on the inner wall surface of the bile duct 6 on the outer circumferential surface of the locking body 11 hollow bile flow and drainage tube 20 is inserted Formed and configured.

That is, the catch 10 is to be performed along the longitudinal direction of the bile duct 6, the catching body 11 is formed in the front end of the round shape, the catching piece 12 is the front of the catching body 11 It is formed integrally to form a smooth curvature toward the rear end and proceeds to the rear side, and may be configured to be deformable in other forms as being configured in a triangular shape in planar projection.

In other words, the hook 10 is easily inserted by the bending action of the locking piece 12 when entering the inside of the bile duct 6, but when proceeding to the opposite side the locking piece 12 is the inside of the bile duct 6 It is caught on the wall so that it does not come off.

In addition, the engaging piece 12 has a pointed triangular cross-section end as it proceeds from the engaging body 11 to the outside, the thickness of the center side is about 1 ~ 1.5mm to facilitate the insertion operation and the locking action for the procedure Is configured, the total length may be configured to about 1 ~ 1.5mm but the value for the size of the locking piece 12 at this time may be configured differently depending on the diameter of the bile duct (6).

In addition, the locking piece 12 is formed to be thinner than the thickness of the locking body 11 so that the thickness of the locking piece 12 is melted and disassembled in a faster time than the locking body 11 by the body fluid when remaining in the body.

The drainage pipe 20 may be inserted into the end of the drainage pipe 20 in the present invention can be directly coupled to the inner diameter of the locking body 11 of the locking hole 10 itself in the form of a long hollow tube. It consists of a structure which forms and combines the pipe | tube 21.

As shown in Figure 4a to Figure 4c, in another embodiment the stent 200 is configured to be fitted to correspond to both ends of the drain pipe 20 to form a pair of two fasteners (10).

At this time, both ends of the drainage pipe 20 are formed with insertion pipes 21, respectively, the engaging body 11 of the locking hole 10 is fitted to the insertion pipe 21 is coupled to both sides of the drainage pipe 20 It consists of a corresponding structure.

Such, the stent 200 is configured to prevent flow from the upper direction to the lower direction of the bile duct 30, the lower direction to the upper direction.

In addition, the outer circumferential surface of the locking body 11 and the drainage tube 20 of the locking hole 10 may be formed by forming a plurality of discharging holes 13 and 22 to allow bile to be exposed to the outside.

5A and 5B, as another embodiment, the stent 300 includes the catching hole 10 and the drainage pipe 20 integrally formed, and the catching hole 10 has a catching piece at an upper portion thereof. 12 is formed, and the outer circumferential surface of the drainage tube 20 may be configured to be formed with a plurality of discharge holes 22 communicated with the inner space 20a so that bile is exposed to the outside.

That is, the stent 300 is made of a biodegradable polymer component of the catch 10 and the drainage tube 20.

Referring to the operation and operation of the stent of the present invention configured as described above are as follows.

As shown in Figure 6, the bile duct 6 is a passage for supplying bile generated in the gallbladder of the liver (4) to the duodenum (5), when performing the gallstone removal procedure or other procedures of the liver (4) Endoscopy is performed through the bile duct (4). In this case, inflammation occurs due to various causes such as physical damage, chemical damage caused by the therapeutic drug, infection, hypersensitivity reaction, and heat damage. In most cases, the endoscope is intubated. Damage to the teat (the bile duct and the inlet of the pancreatic duct) is the main cause of the occurrence of wounds or inflammation resulting in the narrowed diameter of the bile duct (6).

As such, when the diameter due to inflammation in the bile duct 6 becomes narrow, bile does not flow to the duodenum 5, and if the symptoms persist, the degradation of food is reduced, resulting in indigestion and various symptoms.

That is, in order to enlarge the diameter of the inflammation-producing bile duct 6, a separate endoscope (not shown in the drawing) for stent 100, stent 200, and stent 300 into the bile duct 6. The procedure is to confirm the position.

1) As shown in Figure 6 and Figure 7a, the process of the stent 100 is in the body from the outside of the body after fixing and fixed in the state coupled to the end of the endoscope end coupled to the drainage tube 20 coupled to the stopper 10 Insert it into the inside of the bile duct (6) into the hook (10)-> drainage tube (20)-> endoscope in order to insert, the locking piece 12 of the hook (10) by the elastic force bile duct (6) The warp phenomenon occurs while contacting the inner wall surface of the naturally moved along the inner wall surface of the bile duct (6).

Subsequently, the locking piece 12 of the locking port 10 is caught on the inner wall surface of the bile duct 6 on the upper side of the lesion site where inflammation occurs, and then the separation tube 20 and the endoscope are separated from the stent 100. ) While positioning the inside of the bile duct 6 endoscope is discharged to the outside of the human body to complete the procedure.

Thus, when the procedure is completed, bile flows into the bile duct 6 and flows along the inner space 20a of the hook 10 and the inner space 20a of the insertion tube 21 and the drainage tube 20 at the same time. It enters the small or large intestine through (5) and is used for digestion of food.

In addition, bile is partially discharged through the bile discharge holes 13 and 22 formed in the catching body 11 and the drainage tube 20 of the catching hole 10 at the portion excluding the constricted lesion site, thereby helping to smoothly discharge. Done.

As shown in Figure 7b, after observing the condition in the bile duct 6 over a certain period of time, when the inflammation is restored to its original diameter, reinsert the endoscope to pick up the drainage tube 20 to catch the catch 10 and At this time, the hanging hole 10 is not caught on the inner wall surface of the bile duct 6 is melted by the locking piece 12 is easily discharged out of the stent 100 with the endoscope to the outside of the human body.

That is, the portion of the locking piece 12 in contact with the inner wall surface of the bile duct 6 is thinner and thinner than the locking body 11 so that it is easily melted by the body fluid and loses the locking function.

Such, the locking piece 12 of the latch 10 is decomposed by the body fluid after about 3 days to 1 week after the procedure in the bile duct 6 loses the locking action, at this time, Components of the locking piece 12 melted by the body fluid is discharged through the digestive tract.

Thus, by preventing the diameter of the organ existing in the human body, which is a unique role of the stent 100 to be narrowed, it is possible to stably perform the expansion function that allows the secretion fluid secreted from blood or food or organs in the body to flow smoothly. There is an advantage to that.

In addition, the stent 100 has an advantage that does not deviate from the initial procedure position of the stent 100 is caught by the engaging piece 12 on the inner wall surface of the bile duct 6.

In addition, the hanger 10 of the stent 100 is made of a biodegradable polymer that can be biodegradable by the body fluid to eliminate the inconvenience of re-examination to remove without the engaging action of the engaging piece 12 of the hanger 10 And the risk is reduced.

In addition, the locking piece 12 is melted during the removal procedure of the hook 10 to minimize contact with the inner wall surface of the bile duct 6 so as not to cause secondary wounds on the inner wall surface of the bile duct 6. There is an advantage that does not recur.

In addition, as the locking piece 12 is dissolved in the body fluid and the locking action is lost, the removal procedure is simplified, thereby reducing the burden on the patient, such as saving the procedure time and saving the procedure fee.

2) As shown in FIG. 6 and FIG. 8A, the procedure for treating the stent 200 is performed by connecting and fixing one of the couplers 10 coupled to both ends of the drainage tube 20 at the end of the endoscope. After inserting into the body from the outside of the human body to the inside of the bile duct (6) in front of the hanger (10)-> drainage tube 20-> hanger located in the rear (10)-> endoscope in order to insert, The locking piece 12 of the locking hole 10 is in contact with the inner wall surface of the bile duct 6 by an elastic force, and a warpage occurs, thereby naturally moving along the inner wall surface of the bile duct 6.

Subsequently, the locking piece 12 of the locking mouth 10 located in front of the upper portion of the lesion site inflamed is caught on the inner wall surface of the bile duct 6 and at the same time, the locking mouth 10 coupled to the rear is held. Insert the inside of the bile duct 6, and the separation end and the endoscope coupled to the rear end separated by placing the stent 200 inside the bile duct 6 while the endoscope is discharged to the outside of the body to complete the procedure .

At this time, the engaging piece 12 of the coupling hole 10 located in the front to prevent the stent 200 is caught on the inner wall surface of the bile duct 6 is separated from the lower direction, the coupling hole 10 located in the rear The locking piece 12 of the) is to have a supporting function to prevent the stent 200 from being prevented from falling in the lower direction and the locking action to prevent the upward movement of the bile duct 6.

Thus, when the procedure is completed, the bile flows into the bile duct 6 and at the same time the inner space (10a)-> the inner space (20a) of the drainage tube 20 located in front of the trapping jam located in the rear It flows along the internal space 10a of the sphere 10 and enters the small or large intestine through the duodenum 5 and is used for digestion of food.

As shown in Figure 8b, after observing the lesion site condition in the bile duct 6 over a certain period of time, when the inflammation is healed to recover the original diameter, the endoscope is reinserted to stent 200 using the endoscope forceps Pick it up and let it out of the body.

At this time, the locking piece 12 of the latch 10 is decomposed by the body fluid after about 3 days to 1 week after the procedure in the bile duct 6 loses the locking action, body fluids The components of the locking piece 12 melted by the discharge through the digestive tract.

Thus, the stent 200 has the advantage that the engaging port 10 is coupled to the upper and lower portions of the drainage pipe 20 to support the inner wall surface of the bile duct 6 to ensure a stable support force, in addition to other advantages or advantages It will be the same as the stent 100.

In addition, the stent 300 is performed in the same procedure as the stent 100 in an integral shape, in addition to other advantages or advantages will be the same.

The present invention is not limited to the above-described embodiments, and of course, modifications may be made by those skilled in the art without departing from the spirit of the present invention.

In the above, the present invention has been illustrated and described with reference to specific preferred embodiments, but the present invention is not limited to the above-described embodiments and is not limited to the spirit of the present invention. Various changes and modifications can be made by those who have

Figure 1a is a perspective view of a stent applied to the conventional bile duct drainage,

1B is a cross-sectional view taken along the line A-A of FIG. 1A;

Figure 2a is a cross-sectional view of the procedure performed on the lesion site in the bile ducts, Figure 1b

Figure 2b is a cross-sectional view showing the action of the conventional stent engaging piece engaging the inner wall surface of the bile duct healing the lesion site;

Figure 3a is an exploded perspective view of the stent applied to the bile duct drainage according to the present invention,

Figure 3b is a perspective view of the combination of Figure 3a,

3C is a cross-sectional view taken along the line B-B in FIG. 3B;

4A is an exploded perspective view of a stent applied to bile duct drainage according to another embodiment;

Figure 4b is a perspective view of the combination of Figure 4a,

4C is a cross-sectional view taken along the line C-C of FIG. 4B;

5A is a perspective view of a stent applied to bile duct drainage according to another embodiment;

5B is a cross-sectional view taken along the line D-D of FIG. 5A;

6 is a conceptual view showing a position where the stent of FIGS. 3B, 4B, and 5B is performed;

7A is a cross-sectional view of the stent of FIG. 3C performed on the lesion site in the bile duct;

7B is a cross-sectional view showing a state in which the locking action of the bile duct and the locking action are lost due to melting of the stent locking piece of FIG. 7A;

Figure 8a is a cross-sectional view of the procedure of the stent of Figure 4c in the lesion site in the bile ducts,

FIG. 8B is a cross-sectional view illustrating a state in which a locking action of the bile duct is lost due to melting of the stent locking piece of FIG. 8A and healing of the lesion site.

<Description of Symbols for Main Parts of Drawings>

4: liver 5: duodenum

6: bile duct 10: hook

10a: interior space 11: hanging body

12: hanging piece 13: bile discharge hole

20: drainage pipe 20a: internal space

21: insertion tube 22: bile discharge hole

100,200: stent

Claims (5)

The upper and lower portions of the drainage tube body 2 having a plurality of bile discharge holes 1 through which bile is discharged are formed so as to protrude, so that the blood vessels and organs in the body 4 and the duodenum 5 are formed. In the stent to induce smooth flow of bile by inserting into the bile duct 6 to prevent the bile duct 6 to be blocked by the lesion after the endoscopy, A catch 10 made of a biodegradable polymer component that is caught in contact with an inner wall surface of the bile duct 6 so as not to be separated in a downward direction and can be decomposed by melting into body fluids; The drainage pipe 20 is detachably inserted into the hook 10 and guides bile into the duodenum 5; The decomposable hook stent in the body, characterized in that when the healing of the lesion site in the bile duct (6) is completed, the catch 10 is melted and the locking action is lost to facilitate the removal procedure by natural discharge. According to claim 1, wherein the biodegradable polymer of the latch 10 is Poly L-lactic acid (PLLA), Poly lactic acid (PLA), Polyglycolic acid (PGA), Poly glycolide-co-L- lactide acid ), PDO) Polydioxanone) and PGCL (Poly glycolide-co-caprolactone) in one or two or more selected from the body decomposable hook stent, characterized in that mixed with each other. According to claim 1, The latch 10 is a plurality of engaging pieces 12 is caught on the inner wall surface of the bile duct 6 on the outer circumferential surface of the locking body 11 is hollow so that bile flow and drainage tube 20 is inserted In the body decomposable hook stent, characterized in that is formed. The decomposable hook stent according to claim 1, wherein the catching hole (10) is configured to be fitted to correspond to both ends of the drainage pipe (20). The decomposable hook stent according to claim 1, wherein the catching hole (10) and the drainage pipe (20) are integrally formed.

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