KR20100057566A - Compositions of cosmetics for atopy skin containing oriental herbal extracts - Google Patents

Abstract

PURPOSE: A cosmetic composition containing Phellinus linteus, Queri Fructus, green tea, and soybean extract is provided to enhance moisturization and to recover skin barrier function. CONSTITUTION: A cosmetic composition for treating atopic dermatitis contains 0.5-10.0 weight% of Phellinus liteus (L.ex Fr) Quel, fruit of Mulberry tree, Rehmannia glutinosa, green tea, and soybean. The cosmetic composition is used in the form of skin lotion, massage cream, nutrition essence, and emulsion foundation. The extract is obtained by using butylenes glycol and heating in a cooling condenser.

Description

Compositions of cosmetics for atopy skin containing oriental herbal extracts}

Phellinus liteus (L.ex Fr) Quel is a white fungus belonging to the pine vinylaceae family. It is native to the stems of mulberry and hardwoods and is commonly called woody mud or mud mushroom. The growing area is characterized by growing wild in the high altitude of the broad-leaved trees and growing toward the shade of the ground. Therefore, it is found in the trunk of the dead tree, and it is common that wild mushrooms grow perennially for 3 to 4 years.

Situation mushrooms have long been used for uterine bleeding, lobulation, dysmenorrhea, intestinal bleeding, and gastrointestinal function. Recently, the Japanese medical community found that situational mushrooms contained high amounts of high-quality polysaccharides and proteins, as well as anticancer effects. In addition to reports that the blocking rate is more than 90%, studies have shown that it is particularly effective for gastrointestinal cancer, gastric cancer, esophageal cancer, duodenal cancer, colon cancer, rectal cancer and liver cancer.

Although it has protein polysaccharide microorganism, which is a powerful anti-tumor ingredient, it is not used as a pharmaceutical material because its actual effect is small and there is not much extractable amount. It is likened.

This situation mushroom has no taste and aroma. Situation mushrooms have been studied in China and Japan, and their characteristics, drug classification, and forms have been reported. In the Chinese medicinal dictionary, the mushrooms are native to tree trunks and have nicknames Sang-sang, Sang-yi and Si-sang.

Japanese scholars grow wild on the stems of mulberry trees, and have a yellowish color except for the surface. It is called a situation. Especially, when mushrooms are watered, the color is yellow or light yellow and has no taste and aroma.

Situation mushrooms are rarely grown, and it is very difficult to obtain mushrooms grown in nature, and artificial cultivation methods have not been developed. Therefore, it was impossible to develop anticancer components of fruiting bodies as medicines. Liquid cultures and protein polysaccharides isolated therefrom demonstrated superior anticancer effects.

Situation (桑 黃) is derived from China, in our words 'wood mushrooms', the scientific name is Pelinus Linteus (Phellinus. Baomii). The anti-cancer effect of S. mushrooms has been mentioned since 1995, and its effect was revealed as an immune booster, but since the perennial wild mushrooms are so rare and artificial cultivation is so difficult that only small quantities are produced. The deal was made at a higher price. It was also a mycelium that cannot be said to be a perfect mushroom without a spore layer.

The wild situation grows to 3 years to 4 years, and the thicker the shade, the better.

It is also called snowy because it is kept in the form of a bunch of yellow mud in the early stages, and after the grown-up, the tongue is placed on a stump.

The upper part of the tongue-like shape is slightly different depending on the variety of the situation, but it may be colored like mud or black like the skin of persimmon.

When the mushrooms are watered, the color appears yellow or pale yellow. It has no taste

Situation mushrooms. This mushroom, which grows in yellowish colors under the old mulberry trees, is attracting attention to its anticancer effect. wisdom. It might be a strange name for people who think of mushrooms like clusters.

It is a perennial plant that grows up to 1,000 meters in high winters and withstands extreme vegetation and cold cold in winter. It was healed without any help, and the effect is indeed beyond admiration.

Mulberry trees (fruit of mulberry) Mulberry fruit or dried herb. Heartache (桑) · heartache (桑 子) also called. Loss began as a medicine since the Tang Dynasty, the weakness is mild, the taste is sweet. There are many kinds of sugar, and it contains organic acid, mucus, vitamin B1, vitamin B2 and vitamin C.

Pharmacological action is known to have diuretic and Jinhae, tonic action. It is used when dizziness due to anemia, sound in the ears, and pale face. It is also effective when the head suddenly becomes white due to functional weakness of the whole body, the ear is hard to hear and the eyes feel tired and dizzy.

In addition, when used in constipation in the elderly to facilitate the bowel movements to facilitate bowel movements, and when the diabetic patients feel thirsty, thirst is quenched. In addition, nervous breakdown is also effective for those who are sensitive to nerves. Atherosclerosis or high blood pressure caused by heavy and dizzy.

In addition, alcohol detoxification and diuretic action. If a person takes a long time, the lower body becomes healthy, the eyes clear, the gray hair becomes black, and the tonic function is also beneficial. However, diarrhea is not good to use. A typical prescription is Sangsimtang.

Seokgi mushroom is a kind of lichen that occurs on the rocky surface of deep mountains. Lichen is a complex plant in which the mycelium of fungus (aka, fungus) surrounds green algae. Fungi use carbohydrates obtained by photosynthesis of algae (algae), and algae are supplied with water or minerals, protected from drying, forming commensals. There is a custom to sell dried products in the shade, which is made of powder, mixed with glutinous rice flour and beaten with honey to make a kind of terminal. In addition, the black mushrooms are used to make black mushrooms. The history of use in China has been around for a long time, and Seok-gi mushrooms of Mt. Geumgang in Korea are already introduced in Yeochun-chuchu, and the `` Food Resin 대 食 須 '' of Wondae and `` Primary Herb '' of Myeongdae It is also introduced in 本草綱目 ≫.

Stone mushrooms are effective in stopping diarrhea and preventing heat and back pain. In addition, in China, as a jeongjeong (로 精制) is used by the elderly, young and bright eyes

There are many different forms, such as leaf-like, bark-like, glue-like, tree-like. Occurs in trees, rocks, tile, and the ground, and resists drying and cold. Stone mushrooms eat leaf-like originals, and their yields are very low because they are less native and difficult to collect. Necessary for cooking, the taste is light but good. The main producing regions of our country are North Pyongan, South Hamgyong, and Gangwon-do.

Green tea, which has been known as a panacea since its inception, has many healthful ingredients.

Many of the benefits of green tea, such as high blood pressure and diabetes, as well as diet, can not be counted by hand.

Among the green tea's ingredients are caffeine, theanine, tannins, sequisenol (alcohol), and distinctive fragrances.

And the component related to a pigment | dye includes chlorophyll, a carotenoid, etc. Polyphenol, an antioxidant found in green tea, has an anticancer effect.

Green tea is effective in preventing the progression of several diseases such as breast cancer and lung cancer, and also helps prevent Parkinson's disease.

Caffeine is a stimulant for stimulating the central nervous system, so drinking dark green tea can help you sleep better and excite your nerves.

It stimulates respiratory circulatory function and diuretic effect has proved green tea effect related to chronic heart disease,

Caffeine can have a bad effect on the heart of alcohol and drug addicts, but it can help you get rid of your odor quickly.

As it is widely known that green tea-effective cholesterol, which is effective in preventing arteriosclerosis and hypertension, is closely related to diseases such as heart disease, arteriosclerosis, and high blood pressure, cholesterol is regarded as a dangerous substance that adversely affects health.

However, cholesterol in the blood of healthy people contains a certain amount of cholesterol, bile acids, hormones and vitamin D precursors necessary for the absorption of fat is one of the vital substances indispensable for maintaining life. Green tea is also effective in kitchen hygiene due to its high sterilizing power.

Green tea has a very strong bactericidal effect, and the representative food poisoning bacteria Staphylococcus, enteritis vibrio, Staphylococcus aureus, and cholera are known to have a green tea effect that can be sterilized at a concentration lower than that of normal tea drinking.

But in our body it acts as a suit to help the growth of intestinal bifidus bacteria.

It is good to use green tea actively to maintain kitchen hygiene. Especially, if you rinse well with green tea before storing foods such as seafood that are perishable in the summer in the refrigerator, there is a green tea effect that can keep fresh for a long time.

Before using cooking utensils such as cutting boards or knives, rinse and disinfect the green tea and drink green tea when eating raw foods such as sashimi or sushi.

Soybean is an annual plant of the Rosaceae legume. It is widely grown as an edible crop. Since ancient times, soybeans were referred to as soybeans, but nowadays, the seeds of legumes used for food are often referred to collectively. The origin of the beans is assumed to be G. soja, which is also wild in Korea's mountains and fields. There are transitional, intermediate, and semi-cultivated species among cultivars of stone beans and cultivars. All three species can cross each other with 2 ⁿ = 40.

Stem height 60-100 cm. Stems and leaves have brown hairs and grow straight, but some varieties are vine-like. The leaves are alternate, usually a pinnate leaf composed of three small leaves, and the small leaves are oval or elliptical with flat edges. Flowers bloom purple or red in July-August and hang on inflorescences of axillary. Calyx is bell-shaped, and the tip is divided into 5, the lower one being the longest. There are 10 surgeries, each divided into two and one pistil. Fruits are pods, flat, oval-shaped, with 1-7 seeds. Seeds come in various varieties such as yellowish white, black, light brown and green.

In China, the history of beans began around 4,000 BC, and it first appeared in Si Kyung as the name Su. However, the pod resembled a tree made of soybeans, and it became a boiled soybean, and it was classified as soybean or soybean when a small bean bean like a red bean came in. Generally, the wildest, middle, and cultivated species of a plant are the birthplace of the plant, and it is commonly assumed that the origin of soybeans meeting this condition is northeastern China. Some claim that the country of origin is southern China, but soybeans do not appear in the remains of the Yangshuo and Angshan cultures. However, there is a record in Gwanza, where the Chinese Gonggong (제 公) took beans from the northeastern region and distributed them to China, and from the Bronze Age ruins of Odong, Horyyeong-gun, North Hamgyong Province. From this point of view, the origin of soybean can be said to be the northeastern part of Goguryeo land. It was spread through Japan through Korea, and Japanese cultivation history is estimated to be about 2,000 years old. It was first introduced to Europe in 1690 in Europe, first known in 1804 in the United States, and widely cultivated since 1900, and now accounts for 70% of the world's total production. Korea produced 150,000 tons from 270,000 square kilometers in 1955, but produced 97,682 tons in 1998. Jeollanam-do is relatively evenly cultivated in the country, and is especially grown a lot.

If you classify beans according to their purpose, they are common beans for general use, oil beans suitable for squeezing oil, rice beans for eating in rice, bean sprouts (scavenger bean) and green onions for growing bean sprouts. They are divided into green bean beans, which are used as feed for livestock. In addition, they may be classified according to the size or ecological characteristics of the seeds. Most of Korea's superior soybean varieties are domestic varieties. Gwanggyo (the whole country except Jeju), Bongui (Gangwon-do), Northeast Tae (Chungcheongbuk-do), Ganglim (Jeollanam-do, Gyeongsangnam-do), Monoleaf (Jeollabuk-do, Gyeongsangnam-do) Province) Eundae Soybean (Jeju Island) Hill Bean (Jeju Island) Baekcheon (Jeju Island) Changbaek Bean (National) Namcheon Kong (Gyeongsangnam-do and North Gyeongsang Province). The main varieties are Deokyu Soybean Mildew, White Bean, Radial Bean, New Bean, Bokwang Bean, Danggyeong Bean, and Milk Bean.

The growth temperature of soybean grows well at a high temperature of 25 ~ 30 ℃, but it is good to have a warm and humid environment until mid-growth, but the difference between day and night is good for fruiting season. Soil or loam soil, which has little soil cover but is rich in organic matter and lime, is good. The proper soil pH is 6 ~ 7, and it is safe to adjust the soil acidity by spraying lime because field soil in Korea is strong in acidity. Sowing is usually in mid-to-late May, with the wings of 60cm of erect, and 3-4 eggs in one batch at intervals of 15-20cm. Usually, 7-10 tons of seeds are required per 10 a. Soybeans do not have to give a lot of nitrogen because the root black bacterium fixes and supplies air nitrogen, but to obtain a large quantity and maintain intellect, the manure should be properly given. 400 to 800 kg of manure per 10a, 2 to 4 kg of nitrogen, 3 to 5 kg of phosphoric acid, and 4 to 6 kg of potassium are used as manure. After sprouting, it is tied with seaweed two or three times at intervals of two to three weeks. After sowing, spraying herbicides on the front of the field in accordance with varicose veins inhibits the occurrence of weeds. Insects include viral diseases, red fungal diseases, purple pattern diseases, leaf tinnitus moth, and bean moths, which are controlled by insecticides and fungicides and grown as disease-resistant varieties.

When the leaves are dried and fall off, and the pods are fully matured, they are cut with scythes or plucked from the roots to dry and thresh, and the moisture content is stored to 14% or less. Summer beans are harvested in July and August and autumn beans are harvested around October. Beans contain many nutrients, including 30-50% protein, 13-25% fat and vitamins, and are widely available depending on their ingredients and quality. In Korea, it is most commonly used for food and is eaten in rice or used for corrosion such as processed food or bean sprouts such as soybean paste, soy sauce, red pepper paste, tofu and bean curd. In addition, it is used for various purposes by squeezing oil and soybean jelly is also widely used as manure and feed. Soybean pods are a good source of food and are fed with livestock. Soybeans are also used in a variety of industrial raw materials, such as casein adhesives, celluloid substitutes, plastic water-soluble paints, glycerin and soaps.

Jihwang [地 黃 / Rehmannia glutinosa] is a perennial herb of the moss family of the Korean ginseng. 10-30 cm in height. The whole gray white hairs and hairs are dense. Root stock is reddish brown, extending downward at first, and later growing long sideways. Cultivated roots are enlarged. The leaves are many at the root side, long oval, 3 ~ 10㎝ long, 1.5 ~ 4㎝ butterfly. The leaf edges have coarse teeth, and the base gradually narrows, and long petioles hang. Leaf surface has many wrinkles. In early summer, one stalk comes out, and a few small leaves face up. At the end of the long sack of the leaf axilla, 3 to 4 cm long pink purple flowers hang one by one. Calyxes are bell shaped, split into 5 ends, and the calyx is long, ended, and split into 5 pieces. The lobe is obtuse. There are four stamens and they are located at the bottom of the cylinder, two of which are long. There is one pistil attached to the ovary. Capsules are round or egg-shaped with pointed ends and contain several seeds. It is cultivated wildly in dry gravel fields, slopes and roadside soils, and its roots are used for medicinal purposes. Cultivated varieties of northern Henan Province, China, are 40cm in height and have very large root stems, and are known for their high quality. In oriental medicine, it is called Seonjihwang (이라 地 黃) to wash canned stems in water from September to October, and dried ones are called saengjihwang or dried jihwang, and it is steamed by adding sulfur wine (黄酒; Chinese brewed liquor). When it is taken out and dried, it is called Hwang Ji Hwang. It has a bitter sweet taste and is used for the treatment of anemia, uterine bleeding, dysmenorrhea, low back pain, diabetes, bruises, and boils. It is distributed in Korea, China, and Japan.

The term atopy (atopy) has the meaning of "weird" or "inappropriate", and the cause of atopic dermatitis is not yet clearly identified, so the symptoms are also expressed in various ways, such as dry skin, eczema. Atopic dermatitis, also known as fever, is accompanied by chronic diseases of the skin, as well as allergic diseases such as hay fever. This disease is called allergic eczema, pediatric eczema, ectopic eczema, pancreatic neurodermatitis, etc., and is a clinical category of clinical and histological processes that show progression from infant eczema to typical thyroid dermatitis in boys, puberty, and adults. . Atopic dermatitis is a chronic relapsing eczema disease, the cause and pathogenesis of which are not clear. Although atopic dermatitis is currently understood to be mainly caused by a unique genetic predisposition, the pathogenesis is not simple and is caused by multi-factorial. Several external environmental factors that are involved in exacerbation of atopic dermatitis are well known, and the genetic predispositions present in patients with atopic dermatitis and their families, as well as their clinical and immunological forms, are currently weak. Immunological abnormalities due to genetic predisposition have been understood as the main etiology, and evidences suggest immunological abnormalities such as increased blood Ig E, increased IL-4 and IL-5, and decreased INF-γ. However, the most clinically characteristic findings of dry skin and eczema are not explained as immunological abnormalities, and it is not clear whether they are genetic or secondary to atopic dermatitis.

Skin abnormalities observed in atopic dermatitis include abnormally reduced stratum corneum cell size or increased epidermal cell layer thickness. Also, the water content in the stratum corneum is reduced and the water content in the epidermis is inferior.

The natural moisturizing factor is reduced. As a result, transepidermal water loss is increased. The amount of lipids in the stratum corneum is reduced, and the amount of ceramide is reduced due to disorders of ceramide synthesis.

In the mechanism of allergic atopy, when allergens invade through the stratum corneum and reach the epidermal cells, macrophage (macrophage), a type of white blood cell, eats it and breaks it down. When macrophages cannot handle all of them because of the high amount of allergens invaded, they send information about the presence of untreated allergens to T cells, the same type of leukocytes, that control immunity and suppression. . T cells transmit the information back to eosinophils (eosinophilic leukocytes), a type of white blood cells, that bring eosinophils widely distributed in the blood to places where allergens invade. At this time, the eosinophils accumulated in the affected area cause inflammation due to excessive release of a chemical transfer material (active oxygen).

Usually, atopic dermatitis begins with infant eczema, commonly referred to as febrile fever, and itchy skin during the acute phase, with reddening, swelling, millet-like growth, small blisters, moist scabs, and itching in the chronic phase, The skin may become hard, thick, thin, or may have scales such as rice powder sitting or darkening or whitening.

Among the currently used therapeutic drugs, steroids (adrenal corticosteroids) have excellent effects on anti-inflammatory and immunosuppressive effects. However, one thing to watch out for is the side effects of steroids. Long-term application can cause hair to shine on the skin, shrink the skin, reduce skin pigments, cause bacterial infections, acne, thin skin, and uneven skin. In severe cases, hormonal systemic symptoms may occur and stop using the drug, and the symptoms may explode again. Also, systemic administration of the adrenal cortex is not recommended because the development of atopic dermatitis is common in infants before the age of five. Therefore, steroid ointments with very low hormone levels should be used only when necessary for a short period of time, and should be applied frequently instead of applying large amounts at once.

Antihistamines can be used as a temporary measure to relieve itching by preventing histamine from being released from mast cells, which can cause side effects such as insomnia, anxiety and loss of appetite.

Atopic dermatitis is more scary than secondary bacterial infections caused by itching and scratching. The skin of atopic patients is accompanied by bacterial infection as a result of prolonged scraping and drying. More than 90% of atopic patients are infected with Staphylococcus aureus, which is caused by scratching the patient's unbearable itching, and recent reports suggest that the toxins in these bacteria stimulate the body's immune system and cause allergies. It is said to make atopic dermatitis worse. In other words, the bacteria themselves act as allergens. Therefore, the use of appropriate antibiotics is essential for the treatment of atopy. In addition, there are nonsteroidal ointments for drug treatment. This is a type of moisturizer, which is applied at night to moisturize and then wrap it with a wrap. Moisturizing is an important part of the management of atopic dermatitis because dry skin, which is one of the symptoms of atopic dermatitis, tends to cause itching and eczema and is a factor of recurrence and exacerbation of atopic dermatitis.

In addition, sedatives or neurostabilizers may be used to calm the patient.

From the characteristics of the atopy, it can be seen that the development of a substance without side effects while providing antibacterial, moisturizing effect, anti-inflammatory effect, free radical scavenging effect and antioxidant effect as essential items of the atopy treatment.

On the other hand, Korean Patent No. 370455 discloses a composition for improving atopy comprising soy extract, trihydroxy palmitic acid and N-stearoyl-phytosphingosine, and Korean Patent No. 377262 improves atopy containing mugwort extract. The present invention discloses a cosmetic composition, and Korean Patent Application Publication No. 2003-32631 discloses a cosmetic composition for treating atopic dermatitis, including plant extracts such as jujube, vinegar liquor, aloe and the like.

Throughout this specification, reference is made to a number of patent documents, and the disclosures of the cited patent documents are incorporated herein by reference in their entirety, and the level of the technical field to which the present invention belongs and the contents of the present invention are more clearly explained. .

The present inventors searched a number of natural products to overcome the shortcomings of the raw materials having a healing effect of conventional atopic skin and to find a substance having an excellent effect on improving atopic skin. , Extracts of green tea, soybean and turmeric improve the skin's moisturizing function and control the formation of the stratum corneum to restore the barrier function, improve the dryness of atopic dermatitis and the resilience of damaged skin barrier and improve the itch Through this action, it is possible to improve atopic dermatitis, and in particular, by using a mixed extract in combination at an appropriate ratio than using each single extract alone, thereby showing an increased effect. The present invention has been completed to improve atopic skin. Accordingly, an object of the present invention to provide a cosmetic composition for improving atopic skin.

Other objects and advantages of the invention will be apparent from the following examples and claims.

Example: Process for preparing a situation extract, mushroom, locust mushroom, green tea, soybean, turmeric

Example 1. 200g of dried dried mushrooms, 400g of loss, 200g of shiitake mushrooms, green tea, soybean, and turmeric were extracted by heating 100 g of distilled water in 5 kg of distilled water at 100 ° C. for 3 hours. . After filtration through a 400 mesh filter cloth and cooled to room temperature, the mixture was left at 5-15 ° C. for 7 days and finally filtered through a 0.3 μm filter to obtain 4 kg of liquid extract.

Example 2 dried dried mushrooms 200g, 400 g of loss, 200 g of shiitake mushrooms, green tea, soybean, and turmeric, each 100 g of 5% of 30% alcohol and heated at 70 ° C. in an extractor equipped with a cooling condenser for 3 hours Extracted. After filtration through a 400 mesh filter cloth and cooled to room temperature, the mixture was left at 5-15 ° C. for 7 days, finally filtered through a 0.3 μm filter, concentrated under reduced pressure, and 70 g of a powder extract was obtained.

Example 3 dried dried mushrooms 200g, 400g of loss, 200g of shiitake mushrooms, green tea, soybean, and turmeric, each 100g in 5 kg of 95% alcohol and heated at 70 ℃ for 3 hours in an extractor with a cooling condenser Extract. After filtration through a 400 mesh filter cloth and cooling to room temperature, the mixture was left at 5-15 ° C. for 7 days, finally filtered through a 0.3 μm filter, concentrated under reduced pressure, and 45 g of a powder extract was obtained.

Example 4 200 g of dried edible mushrooms, 400 g of loss, 200 g of shiitake mushrooms, green tea, soybean, and turmeric, each 100 g of 5 kg of 30% butylene glycol in a extractor with a cooling condenser at 85 ° C. for 3 hours Extracted by heating. After filtration through a 400 mesh filter cloth and cooled to room temperature, the mixture was left at 5-15 ° C. for 7 days and finally filtered through a 0.3 μm filter to obtain 4 kg of liquid extract.

Example 5 100 g of dried dried mushrooms, 400 g of loss, 200 g of shiitake mushrooms, green tea, soybean and turmeric were added to 5 kg of 30% propylene glycol and heated at 85 ° C. for 3 hours in an extractor equipped with a cooling condenser. , Extracted. Filtration with a 400 mesh filter cloth, cooled to room temperature and left for 5 days at 5-15 ℃, and filtered with a final 0.3 ㎛ filter to obtain a liquid extract 4kg.

Example 6 200 g of dried situation mushrooms, 400 g of loss, 200 g of shiitake mushrooms, green tea, soybean, and turmeric, each 100 g of 5% of 30% glycerin in 30 kg of glycerol, boiled for 3 hours in an extractor with a cooling condenser, and then extracted, 400 Filtered with a mesh filter cloth, cooled to room temperature and left to mature for 5 days at 5-15 ℃, then filtered with filter paper 5 and finally filtered with a 0.3 ㎛ filter to obtain a liquid extract 4kg.

Example 7 Dried 200 g of dried mushrooms, 400 g of loss, 200 g of shiitake mushrooms, green tea, soybean, and turmeric were added to 5 kg of 30% methanol in 30 kg of methanol and heated at 70 ° C. for 3 hours in an extractor equipped with a cooling condenser. Extracted. After filtration through a 400 mesh filter cloth and cooled to room temperature, the mixture was left at 5-15 ° C. for 7 days, finally filtered through a 0.3 μm filter, concentrated under reduced pressure, and 40 g of a powder extract was obtained.

Example 8 200 g of dried dried mushrooms, 400 g of loss, 200 g of shiitake mushrooms, green tea, soybean, and turmeric were added to 5 kg of 30% ethyl acetate and heated at 70 ° C. for 3 hours in an extractor equipped with a cooling condenser. Extracted by. After filtration through a 400 mesh filter cloth and cooled to room temperature, the mixture was left at 5-15 ° C. for 7 days, finally filtered through a 0.3 μm filter, concentrated under reduced pressure, and 42 g of a powder extract was obtained.

The present invention relates to a composition and cosmetics comprising the same to improve the moisturizing function of the skin and to restore the barrier function by regulating the formation of the stratum corneum to improve the dry skin of atopic dermatitis and the recovery of damaged skin barrier. More specifically, it contains 2 to 2: 2: 2: 2: 1: 1 of Situation Mushroom, Lost Mushroom, Sacred Mushroom, Green Tea, Soybean, and Turmeric to improve the itch of atopic dermatitis and enhance skin barrier function. The present invention relates to a composition for improving the moisturizing and drying effects and the resilience of damaged skin barriers.

Long-term measurements of 4 weeks showed changes in facial skin moisture content.

Experimental Example 1: Moisturizing Effect Experiment

Moisturizing effect was measured using each of the seven extracts from Examples 1 to 7. Twenty women in their twenties were divided into 12 sections in the range of 2 × 2 ㎠ and washed several times with water to remove moisture without irritation. After 5 minutes, 10 μl of purified water and Examples 1 to 7 were applied dropwise to each of the two compartments to be evenly applied. After 10 minutes, five measurements were taken per compartment using Corneometer CM 825 (Courage + Khazaka) and seven measurements were taken at five minute intervals. The room temperature was 20 ° C and the relative humidity was 20%. The results are shown in Table 1 below, with each value being the average for 20 people.

Determination of Moisturizing Effect of Extracts Minutes Purified water Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 10 11.2  27.5 29.6 41.2 31.3 37.4 38.5 24.4 15 10.5 25.5 28.6 40.2 30.2 35.2 34.5 23.5 20 10.2 23.2 24.5 39.8 29.4 30.2 33.2 20.5 25 9.8 20.3 23.2 37.5 27.6 29.5 31.5 19.5 30 9.5 20.1 22.1 36.5 24.5 27.6 30.2 18.3 35 8.7 19.5 20.1 34.5 23.5 26.5 29.5 15.6 40 7.5 17.2 19.5 33.2 22.5 25.5 27.5 14.3

In the case of Example 3, the moisturizing power of the extraction method was increased, and the holding power was also improved.

Formulation Example 1 Formulation examples of a lotion (skin lotion) in cosmetics containing a situation mushroom, a loss, shiitake mushroom, green tea, soybean and turmeric mixed extract (Example 3) are shown in Table 2.

Number  Raw material Formulation Example 1
(weight%) Comparative Example 1
(weight%) One Mixed extracts such as situation mushrooms, loss, stone mushrooms, green tea, soybean, and turmeric 5.0 - 2 glycerin 3.0 3.0 3 Butylene Glycol 2.0 2.0 4 Propylene glycol 2.0 2.0 5 Polyoxyethylene (60) Cured Castor Oil 1.0 1.0 6 ethanol 10.0 10.0 7 Triethanolamine 0.1 0.1 8 antiseptic a very small amount a very small amount 9 Pigment a very small amount a very small amount 10 Spices a very small amount a very small amount 11 Purified water TO 100 TO 100

Formulation Example 2

Examples of the formulation of nutritional lotion in cosmetics containing a situation mushroom, a loss, a mushroom, a green tea, a soybean, a turmeric mixed extract (Example 3) are shown in Table 3.

Number  Raw material Formulation Example 2
(weight%) Comparative Example 2
(weight%) One Sichuan mushrooms, dried mushrooms, shiitake mushrooms, green tea, soybeans, turmeric 10.0 - 2 Beeswax 1.0 1.0 3 Polysorbate 60 1.5 1.5 4 Sorbitan sesquioleate 0.5 0.5 5 Liquid paraffin 10.0 10.0 6 Sorbitan stearate 1.0 1.0 7 Lipophilic Monostearic Acid Glycerin 0.5 0.5 8 Stearic acid 1.5 1.5 9 Glyceryl Stearate / Pig-400 Stearate 1.0 1.0 10 Propylene glycol 3.0 3.0 11 Carboxy Vinyl Polymer 0.1 0.1 12 Triethanolamine 0.2 0.2 13 antiseptic a very small amount a very small amount 14 Pigment a very small amount a very small amount 15 Spices a very small amount a very small amount 16 Purified water TO 100 TO 100

Formulation Example 3

Examples of the formulation of nutritional cream in cosmetics containing a situation mushroom, loss (실), stone mushroom, green tea, soybean, turmeric mixed extract (Example 3) are shown in Table 4.

Number  Raw material Formulation Example 3
(weight%) Comparative Example 3
(weight%) One Sichuan mushrooms, dried mushrooms, shiitake mushrooms, green tea, soybeans, turmeric 10.0 - 2 Beeswax 8.0 8.0 3 Polysorbate 60 1.5 1.5 4 Sorbitan sesquioleate 0.5 0.5 5 Liquid paraffin 20.0 20.0 6 Sorbitan stearate 1.0 1.0 7 Lipophilic Monostearate Glycerin 0.5 0.5 8 Stearic acid 1.5 1.5 9 Glyceryl Stearate / Pig-400 Stearate 1.0 1.0 10 Propylene glycol 6.0 6.0 11 Triethanolamine 0.2 0.2 12 antiseptic a very small amount a very small amount 13 Pigment a very small amount a very small amount 14 Spices a very small amount a very small amount 15 Purified water  TO 100  TO 100

Formulation Example 4

Examples of the formulation of the massage cream in the cosmetic composition containing a situation mushroom, a loss (桑 實), a stone mushroom, green tea, soybean, and a turmeric mixed extract (Example 3) are shown in Table 5.

Number  Raw material Formulation Example 4
(weight%) Comparative Example 4
(weight%) One Sichuan mushrooms, dried mushrooms, shiitake mushrooms, green tea, soybeans, turmeric 10.0 - 2 Beeswax 10.0 10.0 3 Polysorbate 60 1.5 1.5 4 Sorbitan sesquioleate 0.8 0.8 5 Liquid paraffin  40.0  40.0 6 Squalane  5.0  5.0 7 Lipophilic Monostearic Acid Glycerin 1.0 1.0 8 Carboxy Vinyl Polymer  0.2  0.2 9 Butylene glycol 6.0 6.0 10 glycerin 6.0 6.0 11 Triethanolamine 0.2 0.2 12 antiseptic  a very small amount  a very small amount 13 Pigment  a very small amount  a very small amount 14 Spices  a very small amount  a very small amount 15 Purified water TO 100 TO 100

Formulation Example 5

Examples of the formulation of nutritional essences in cosmetics containing a situation mushroom, a loss, a mushroom, a green tea, a soybean, a turmeric mixed extract (Example 3) are shown in Table 6.

Number  Raw material Formulation Example 5
(weight%) Comparative Example 5
(weight%) One Sichuan mushrooms, dried mushrooms, shiitake mushrooms, green tea, soybeans, turmeric 10.0 - 2 Cytostolol 13.0 13.0 3 Polyglyceryl 2-oleate 0.2 0.2 4 Ceramide 0.1 0.1 5 Ceteares-4  5.0  5.0 6 cholesterol  0.3  0.3 7 Dicetylphosphate a very small amount a very small amount 8 Concentrated glycerin  1.0  1.0 9 Macadamia oil 0.2 0.2 10 Carboxy Vinyl Polymer a very small amount a very small amount 11 Xanthan Gum  a very small amount  a very small amount 12 antiseptic a very small amount a very small amount 13 Spices a very small amount a very small amount 14 Purified water TO100 TO100

Formulation Example 6

Examples of the formulation of the emulsified foundation in the cosmetics containing the situation mushroom, loss (실), stone mushroom, green tea, soybean, turmeric mixed extract (Example 3) are shown in Table 7.

Number  Raw material Formulation Example 6
(weight%) Comparative Example 6
(weight%) One Sichuan mushrooms, dried mushrooms, shiitake mushrooms, green tea, soybeans, turmeric 10.0 - 2 Beeswax  2.0  2.0 3 Pyromethicone  2.0  2.0 4 Liquid paraffin 5.0 5.0 5 Squalane 5.0 5.0 6 Stearic acid  2.0  2.0 7 Lipophilic monostearic acid glycerin 3.0 3.0 8 Macadamia oil 4.0 4.0 9 glycerin 4.0 4.0 10 Propylene glycol 3.0 3.0 11 Butylene glycol  3.0  3.0 12 Triethanolamine 1.0 1.0 13 Aluminum Magnesium Silicate 0.5 0.5 14 Pigment  12.0  12.0 15 antiseptic a very small amount a very small amount 16 Spices a very small amount a very small amount 17 Purified water TO100 TO100

Experimental Example 2: Test of resilience after skin barrier injury in hairless mice

Acetone was applied as a method of skin barrier damage. When transepidermal water loss (TEWL) reaches 4.0 g / m ² / h by dropping acetone into the embryos of 8-12 week old hairless mice, the composition of Table 2,3,4,5,6,7 This contained sample was applied to an area of 5 cm ² . TEWL was measured with Tewameter 210, an evaporimeter from CK (Courage + Khazaka, Cologne, Germany). After 6 hours of application, TEWL was measured to evaluate the extent to which TEWL was reduced to evaluate the extent to which skin barrier function was restored. The recovery rate used for the efficacy evaluation was calculated as in Equation 2 below and the results are shown in Table 8.

Bt = 6: TEWL measured 6 hours after skin barrier injury

Bt = 0: TEWL measurement before skin barrier injury

Bt = d: TEWL measurement immediately after skin barrier damage

Recovery rate (%) Comparative Example 1 Formulation Example 1 Comparative Example 2 Formulation Example 2 Comparative Example 3 Formulation Example 3 Comparative Example 4 Formulation Example 4 Comparative Example 5 Formulation Example 5 Comparative Example 6 Formulation Example 6 6 hours elapsed (based on initial TEWL) 17.2 45.8 39.5 59.5 37.69 70.4  24.5 73.0 52.1 62.3 53.3 75.8

<Experiment Result>

Looking at the results of Table 8, compared to the case where each component as an active ingredient (Comparative Examples 1,2,3,4,5,6), these components were mixed (Formulation Examples 1,2,3,4, 5,6) showed a recovery effect after skin barrier damage.

Experimental Example 3

 When applying the skin for Formulation Examples 1 to 6, the following experiment was carried out to confirm the effect of improving atopic healing. Atopic dermatitis was examined in 20 patients who had atopic dermatitis over 5 years. To the same person, the formulation example of Formulations 1 to 6 on the left hand and the cosmetic formulations of Comparative Examples 1 to 6 on the abdominal right hand after every evening, and then applied to the skin once a day for 60 days, in order to confirm the improvement of atopic condition The degree of atopic condition improvement was measured.

division Improve Atopy Condition Prescription example (1-6) very good 15 75.0 good 3 15.0 is average 2 10.0 so so 0 00.0 Comparative prescription example (1-6) very good 0 00.0 good 2 10.0 is average 7 35.0 so so 11 55.0

As shown in Table 9, the cosmetics of the formulation example prepared by adding the above situation mushrooms, loss (桑 實), shiitake mushrooms, green tea, soybean, and turmeric mixed extract (Example 3) have a better healing improvement effect than the comparative example. Could know. The change in the facial skin moisture content over a long period of 4 weeks is shown in FIG.

Claims (6)

Cosmetic composition, characterized in that it contains 0.5 to 10.0% by weight of a conventional mushroom composition, a situation mushroom, a loss, shiitake mushroom, green tea, soybean, turmeric mixed extract.
The herbal cosmetic composition according to claim 1, which contains 0.5 to 10.0% by weight of a situation mushroom, a loss, a mushroom, a green tea, a soybean, and a sulfur extract.
The herbal cosmetic composition for atopic dermatitis according to claim 1, which contains 0.5 to 10.0% by weight of a situation mushroom, a loss, a mushroom, a green tea, a soybean, and a sulfur extract.
The cosmetic composition according to claim 1, wherein the cosmetic composition is a formulation of a lotion (skin lotion), nutrition lotion, nutrition cream, massage cream, nutrition essence, emulsified foundation.
The extract of claim 1 or 2, wherein the extract of the situation mushroom, the loss, the oyster mushroom, the green tea, the soybean, and the turmeric is extracted by adding a butylene glycol in an extraction process and heating in an extractor equipped with a cooling condenser. Cosmetic composition characterized in that.
The cosmetic composition according to claim 1 or 2, which has a moisturizing effect and an action of restoring skin barrier in a cosmetic composition containing a situation mushroom, a loss, a stone mushroom, a green tea, a soybean, a sulfur-containing mixture extract Composition.

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