KR20100004547A - Silicone gel patch for cosmetic and the method for preparing thereof - Google Patents

Abstract

PURPOSE: A silicon gel patch for cosmetic product and a method for producing the same are provided to improve anti-wrinkle, whitening, and moisturization. CONSTITUTION: A silicon gel patch for cosmetic product contains a support and silicon adhesive layer containing skin active ingredient. The silicon adhesive layer is platinum-catalyzed curing silicone adhesives. The silicon adhesive layer is applied on the support in the thickness of 0.001 cm~2 cm. The support is silicon membrane or non-woven fabric. A method for producing the silicon gel patch for cosmetic product comprises: a step of mixing skin active ingredient to silicon part comprising cross-linking site; a step of mixing silicon part with mixing liquid; a step of applying mixing liquid on a backing film; a step of forming silicon gel; and a step of cutting silicon gel and packaging.

Description

Silicone gel patch for cosmetic and the method for preparing the same

The present invention relates to a silicone gel patch for cosmetics and a method for manufacturing the same, and more particularly, by containing various skin active ingredients in a silicone gel formulation excellent in adhesion, breathability, and fit, excellent absorption when attached to the skin and improve skin wrinkles The present invention relates to a cosmetic silicone gel patch and a method for producing the same, which show excellent effects on whitening, moisturizing, removing blemishes, removing blotch, and slimming.

A patch is a type of drug delivery system (DDS) that controls the release rate and the penetration rate of the drug by attaching it to the skin so that the drug penetrates the skin at a constant rate so that the drug can be continuously expressed. The drug delivery system refers to a formulation designed to efficiently deliver the required amount of drug to the desired area by minimizing the side effects of the existing medicine and maximizing the efficacy and effect, and emerged as a key element of drug development as technology innovation progresses. Doing. Among DDS, Transdermal Drug Delivery System (TDDS) is used for patch, plasters, pasta, cataplasma, gel, ointment, lotion. It is a technology that delivers blood through the skin into the blood by using lotion, cream, or electric devices. It can avoid metabolism by the liver or stomach, so that the drug is exerted immediately and the drug adheres to the skin. It is possible to administer the drug continuously, so you do not need to take it every day. Patches are most commonly used for transdermal drug delivery, and the rate of drug release and skin permeation is controlled so that the drug penetrates the skin at a constant rate so that the drug can be continuously expressed. Almost no side effects, as well as drugs are delivered to the body at a constant rate can keep the drug for a long time.

Patches used in the pharmaceutical and cosmetic industries generally include wet type, which is used by soaking fluid in a nonwoven fabric, dry type, water-soluble gel, and oil-soluble gel, which contain an active ingredient in lyophilized collagen sheets. It is classified as a gel type containing all. Among them, the water-soluble gel is subdivided into polyacrylic acid type and agagel type, and the oil-soluble gel is subdivided into polyacrylic adhesive type and silicone adhesive type.

Oil-soluble gel is known to be easily adhered to the skin because of its hydrophobic nature, and is known to be excellent in terms of drug delivery and compatibility and efficacy with the skin, but is more familiar for medical use than cosmetics and its application in cosmetics. Is not much. Soluble gels have been mainly used for band-type polyacrylic adhesives for medical purposes, but recently, with the modification of polyacrylic adhesives and the development of film film material, the function of the film film is enhanced to one-dimensional level. We are making a big turn. That is, it is important to enhance the permeability of the vapor (Vapor) while showing an effective occlusivity, functional polyurethane, polyester film and the like are widely used as such a material. In addition, studies on the skin affinity of the polyacrylic adhesive have been conducted, and by utilizing the skin affinity and the skin always enough, the technology has been widely applied by converting the skin regeneration system into a wet regeneration method instead of a dry regeneration method.

Water-soluble gel and wet type are most commonly used for cosmetics, and dry and oil-soluble gels having excellent efficacy and customer recognition are used for medical purposes.

Cosmetic patches should be capable of supporting the active ingredients of skin that can be expected to moisturize, soothe, age, remove dead skin cells and wastes, recover tired skin, increase elasticity and whitening, and are comfortable to wear, soft to fit and convenient, Cosmetic effects such as meeting the conditions of breathability and the like should be satisfied at the same time. However, in the case of a water-soluble gel and a wet type that is used for a lot of cosmetics, it is difficult to support the hydrophobic beauty component, it can not be attached for a long time due to the flow down by moisture and cold feeling and evaporation of moisture.

Therefore, the inventors of the present invention have repeatedly carried out a study of patch formulations capable of supporting skin active ingredients and excellent skin adhesion, and using silicone gels in cosmetic patch formulations can not only support various skin active ingredients, but also with excellent adhesion. The present invention has been found to be able to adhere to the skin for a long time.

Therefore, the object of the present invention by using the silicone gel in the cosmetic patch, excellent adhesion, breathability, wearing comfort and support the skin active ingredients to improve the skin wrinkles, whitening, moisturizing, blemishes removal, mushroom removal and slimming To provide a cosmetic silicone gel patch and a method for producing the same.

The present invention to achieve the above object; And a silicone pressure-sensitive adhesive layer coated on the support and including a skin active ingredient, and provides a cosmetic silicone gel patch in a gel formulation.

In addition, the present invention

1) blending a skin active ingredient into a silicone part including a crosslinking site;

2) stirring the silicone part including the crosslinking catalyst with the compounded solution of 1);

3) applying the stirring solution of 2) on the support;

4) aging the contents of 3) to form a silicone gel having a silicone pressure-sensitive adhesive layer formed on the support; And

5) cutting and packaging the silicon gel formed in 4)

It provides a method for producing a cosmetic silicone gel patch comprising a.

The silicone gel patch for cosmetics according to the present invention is not only able to adhere to the skin for a long time due to its excellent adhesiveness, but also supports various skin active ingredients to improve skin wrinkles, whitening, moisturizing, removing blemishes, removing blotch, and slimming effect. It is very superior to the products and shows high satisfaction in breathability and fit.

The present invention is a support; And a silicone pressure-sensitive adhesive layer coated on the support and including a skin active ingredient, and provides a cosmetic silicone gel patch in a gel formulation.

In addition, the present invention

1) blending a skin active ingredient into a silicone part including a crosslinking site;

2) stirring the silicone part including the crosslinking catalyst with the compounded solution of 1);

3) applying the stirring solution of 2) on the support;

4) aging the contents of 3) to form a silicone gel having a silicone pressure-sensitive adhesive layer formed on the support; And

5) cutting and packaging the silicon gel formed in 4)

It provides a method for producing a cosmetic silicone gel patch comprising a.

Hereinafter, the present invention will be described in more detail.

Silicone gels used in the present invention are platinum-catalyzed Curing Silicone Adhesives. Currently available raw materials include Dow Corning Co.'s 7-9800 Soft Skin Adhesive Kit (Part A & B) or Dow Corning's 7-9700 Soft Skin Adhesive Kit (Part A & B). And silicone adhesives having a similar system are all applicable.

The platinum catalyzed crosslinked silicone pressure sensitive adhesive has the following characteristics.

1) It is characterized by platinum-catalyzed addition reaction (Pt <10 ppm), and the reaction is made of silicone gel adhesive using the addition reaction between SiH and vinyl groups between silicon polymers.

2) A two-part system with low viscosity before curing

3) No by-products, Curing reaction is sensitive to heat

The design of the cosmetic silicone gel patch used in the present invention has a form of applying a silicone gel adhesive layer carrying various skin active ingredients on a support as shown in Figure 1, and protects the adhesive surface with a release liner.

Hereinafter, a method of manufacturing a cosmetic silicone gel patch of the present invention will be described in detail for each step.

1) silicone comprising a crosslinking site In parts  Formulating Skin Active Ingredients

The silicone part including the crosslinking site and various skin active ingredients are mixed together and stirred to be sufficiently mixed. Preferably, bis-vinyldimethicone and hydrogen dimethicone may be used in the silicone part including the crosslinking site, which is preferably contained in an amount of 20.0 wt% to 60.0 wt% based on the total weight of the entire composition of the patch. . If it is out of the above content range, there is a fear that the gel does not form.

The skin active ingredient used in the present invention may support a hydrophobic skin active ingredient or powder dispersible in silicone due to the nature of the adhesive, and improve wrinkles such as retinol, retinyl palmitate, adenosine, or polyethoxyl tyretinamide. Effective ingredients; Ingredients effective in whitening such as arbutin, oil-soluble licorice, ethyl ascorbyl, ascorbyl glucoside, or magnesium ascorbyl phosphate; Ingredients effective for moisturizing, such as chia mushroom polysaccharide, niacinamide or N-acetylglucosamine; Ingredients effective for skin troubles and keratin improvement such as ceramide, chamomile oil or oil-soluble soybean; It may include a slimming ingredient such as caffeine, deanine or ferulina.

Adenosine, which is a wrinkle notification material of the active ingredient, may be contained in an amount of 0.001 to 0.04% by weight. This is because it is determined by the KFDA Wrinkle Notice content when the active ingredient contains 0.04%, and the efficacy is recognized. In addition, KFDA's wrinkle test ingredients such as retinol, retinyl palmitate, and polyethoxyl eltidretinamide can be formulated in stabilized forms such as liposomes and capsules in the limited content range, and can be dispersed and contained in silicone gel within the range. .

Arbutin, the whitening test ingredient of the active ingredient may be contained in 0.01% to 2.0% by weight. 0.01% to 0.3% by weight of young mulberry extract, 0.01 to 0.05% by weight of oil-soluble licorice extract, 0.01 to 2.0% by weight of ethyl ascorbyl, 0.01 to 2.0% by weight of ascorbyl glucoside, 0.01 to 3.0% by weight of magnesium ascorbyl phosphate It can be prepared in powder dispersion or oil dispersion form within the range and can be contained in the silicone gel after preparation.

Skirt mushroom polysaccharide in the active ingredient is 0.01 ~ 5.0% by weight, niacinamide 0.01 ~ 5.0% by weight, N-acetylglucosamine 0.1 ~ 5.0% by weight, soybean extract 0.01 ~ 5.0% by weight, ceramide 0.01 ~ 5.0% by weight, chamomile 0.01 ~ It contains 5.0% by weight, so that the silicone gel can be loaded with ingredients effective for moisturizing, skin trouble, and keratin improvement.

The caffeine in the active ingredient contains 0.01 to 5.0% by weight, deanine 0.01 to 5.0% by weight, ferulina 0.01 to 5.0% by weight, respectively, so that the ingredients effective for slimming can be supported on the silicone gel.

The range can be formulated in a stabilized form, such as liposomes in the notification limit content range of the KFDA, and the efficacy is recognized within the range. In addition, if the content is less than the above range, the effect is insignificant, and if it is contained above the above range, a phenomenon such as irritation to the skin may occur.

At this time, it may include the step of stirring the viscosity control silicone for preventing flow during coating or controlling the properties of the prepared patch, dimethicone of various viscosities can be used. The viscosity-adjusting silicone is preferably contained in an amount of up to 30.0% by weight based on the total weight of the total composition of the patch. In the case of more than that, there is a fear that the gel is not formed.

2) Crosslinking catalyst  Containing silicone Parts  With the compounding solution of 1) Stirring  step

The silicone part including the crosslinking catalyst is separately prepared, stirred with the compound 1), transferred to the coating machine, or mixed using a continuous static mixer, and flowed into the coating machine.

In the silicone part including the crosslinking catalyst used in the present invention, bis-vinyldimethicone and platinum divinyldisiloxane may be preferably used, and are contained in an amount of 20.0 wt% to 60.0 wt% based on the total weight of the entire composition of the patch. It is preferable. If outside the above content range, there is a fear that the gel does not form.

3) of 2) above Stirring solution  Coating on a support

The stirring solution prepared in 2) is applied to the support by flowing a comma coating method to the coater. As the support used in the present invention, a silicon film made of a silicon material or a general nonwoven fabric used in a conventional mask may be used, and most representative of them may be Dow Corning's 7-4107.

In addition, it is preferable to apply a silicone pressure-sensitive adhesive layer containing the skin active ingredient on a support in a thickness of 0.001cm to 2cm. This is because it is difficult to contain a proper amount of agonist at less than 0.001 cm, and when it exceeds 2 cm, the burden is on the skin and the adhesive strength of the patch decreases due to its weight.

4) by aging the content of 3) the silicone on the support Adhesive layer  Formed Silicone gel Forming steps

When the contents of 3) are aged through a heating machine, a silicone gel having a pressure-sensitive adhesive layer containing a skin active ingredient on the support can be obtained. At this time, the temperature of the heating group can be adjusted to 70 ~ 150 ℃, most preferably 90 ~ 130 ℃ depending on the degree of crosslinking and coating speed.

5) formed in 4) above Silicone gel By cutting  Steps to pack

The silicone gel adhesive surface aged through the heating machine is easy to cut during manufacturing, easy to peel off during use, and after applying appropriate release liner to protect the patch from the outside during storage, the desired design Cut and pack.

Hereinafter, although an Example and a comparative example are given and this invention is demonstrated more concretely, this invention is not limited only to these examples.

Comparative Example 1 and Examples 1 to 4 Preparation of Cosmetic Silicone Gel Patches Supporting Skin Active Ingredients

The cosmetic silicone gel patches of Comparative Example 1 and Examples 1 to 4 were prepared in an ingredient content as described in Table 1 below. Dow Corning's Dow Corning 7-9800 Soft Skin Adhesive Parts A and Dow Corning 7-9800 Soft Skin Adhesive Parts B were used for the silicone part including the crosslinking catalyst and the silicone part including the crosslinking site, respectively. Dow Corning's DC 200 (100,000 cst) was used.

The proportion of the silicone parts in Comparative Examples 1 and 1 to 4 can be varied in consideration of patch properties such as gel formation, adhesion, usability and the like. In addition, the skin active ingredients applied in Examples 1 to 4 are known as effective materials for wrinkle improvement, whitening and slimming, and various other skin active ingredients may also be applied. Comparative Example 1, which contains no skin active ingredient, is a medical patch formulation that is currently commercially available.

After the skin active ingredient retinol, oil-soluble licorice and caffeine were blended into the silicone part including the crosslinking site, the silicone part including the crosslinking catalyst was added, stirred, and transferred to the coating machine. The silicone pressure sensitive adhesive containing the skin active ingredient was flowed in a comma method onto the supporter and passed through a heating machine, and then the prepared silicone patch was matured in a aging room.

Ingredient (Unit: wt%) Comparative Example 1 Example 1 Example 2 Example 3 Example 4 Silicone Part with Crosslinking Catalyst (Dow Corning 7-9800 Soft Skin Adhesive Parts A) to 100 to 100 to 100 to 100 to 100 Silicone Parts Containing Crosslinking Sites (Dow Corning 7-9800 Soft Skin Adhesive Parts B) 50.00 50.00 50.00 50.00 42.5 Silicone part for viscosity adjustment (DC 200) - - - - 15 Retinol (10% in soybean oil) - 0.75 - - 0.75 Usability Licorice - - 1.00 - - Caffeine - - - 1.00 -

The silicone gel patches of Comparative Example 1 and Examples 1 to 4 were respectively measured under the following physical property measurement conditions, and sensory tests were conducted on 20 general users. The average was calculated on a 10-point scale, and when it is 5 or more, it shows satisfaction as a cosmetic patch.

<Physical measurement conditions>

1) Support: 2 mils PET (corona treated)

2) Release liner: 4 mils embossed PP film.

3) Curing conditions: 120 ° C./10 min.

4) Peel Adhesion: INSTRON tester, stainless steel panel, 20 minutes wet time, test speed = 12 in./min (30.5 cm / min)

5) Tack: Polyken tester, dwell time = 1 sec, test speed = 0.5 cm / sec

6) Dynamic shear: TA tester, 2 mils PET (untreated) substrate, 20 min wet time, test rate = 0.2 in./min (0.5 cm / min)

ingredient Comparative Example 1 Example 1 Example 2 Example 3 Example 4 Silicone gel coating thickness (cm) 2.0 0.3 0.3 0.3 0.3 Peel Adhesion (g / cm) 20.80 21.33 19.78 20.16 23.85 Tack (g) 51.6 138.2 180.5 160.9 109.0 Dynamic Shear (kg / in ² ) 0.39 0.78 0.56 0.61 0.89 Sensory test (adhesive satisfaction) 7.2 8.1 9.3 8.9 7.6 Sensory test 9.1 9.2 9.1 8.5 8.5 Sensory test 9.5 6.8 8.3 8.0 6.4

As can be seen in Table 2, Examples 1 to 4, despite the thinner silicone gel coating thickness than Comparative Example 1 currently available for medical use compared to Comparative Example 1 as a cosmetic patch product physical properties and satisfaction Showed. In addition, in Example 4 including the viscosity-controlled silicone part, there was a difference in overall physical properties and slightly lower satisfaction compared to Example 1, in which the viscosity-controlled silicon part was not included, but the ease of coating and physical properties of the patch during manufacture It can be seen that it can be applied as a cosmetic patch when considering the purpose of adjustment.

Comparative Example 2 and Example 5 Skin Absorption Permeation Testing of Retinol-Containing General Essence Emulsifying (O / W) Formulations and Retinol-Containing Silicone Gel Cosmetic Patches

Comparative Examples 2 and 5 were prepared and tested with the components of Tables 3-4, respectively, to compare the retinol skin absorption of the retinol-containing essence emulsifying (O / W) formulation and the retinol-containing silicone gel patch. 2 is shown.

ingredient Comparative Example 2 (Unit: wt%) water to 100 Butylene Glycol 5.000 Disodium EDTA 0.020 Acrylate / C10-30 Alkyl Acrylate Crosspolymer 0.300 Potassium hydroxide Quantity Phytoscualan 4.000 Petrolatum 1.500 Madfoam Seed Oil 3.000 Dimethicone E 6.000 Cetearyl Alcohol 3.000 Cetearyl Alcohol / Cetearyl Glucoside 1.000 Glyceryl Stearate SE 0.500 Glyceryl Stearet. Local affinity 0.500 antiseptic Quantity Spices Quantity Pure retinol 2500 IU / g

ingredient Example 5 (unit: wt%) Silicone Part with Crosslinking Catalyst (Dow Corning 7-9800 Soft Skin Adhesive Parts A) to 100 Silicone Parts Containing Crosslinking Sites (Dow Corning 7-9800 Soft Skin Adhesive Parts B) 50.00 Pure retinol 2500 IU / g

The experiment was performed using the skin extracted from the hairless mouse, and the skin absorption experiment was performed for 6 hours under conditions shielded by a Franz-cell device. After the experiment, a certain amount of skin tissue of the mouse was extracted, and the concentration of retinol absorbed into the skin tissue was measured by high performance liquid chromatography.

As can be seen in Figure 2, the cosmetic silicone gel patch of the present invention compared to the general essence emulsifying (O / W) formulations, the skin absorption of the active ingredient is enhanced by about 400% or more. Therefore, when the silicone gel patch for cosmetics according to the present invention is attached for a long time, the skin absorption of the skin active ingredient is increased compared to the general skin care products, which is excellent in wrinkle improvement, whitening, moisturizing, blemish removal, mushroom removal and slimming. The effect can be obtained.

1 is a schematic diagram of a cosmetic silicone gel patch according to the present invention.

Figure 2 is a graph showing the skin absorption permeability of the cosmetic silicone gel patch according to the present invention.

Claims (15)

Support; And It includes a silicone pressure-sensitive adhesive layer coated on the support and comprising a skin active ingredient, Cosmetic silicone gel patch in gel formulation. The cosmetic silicone gel patch of claim 1, wherein the silicone pressure sensitive adhesive layer is platinum-catalyzed Curing Silicone Adhesives. The method of claim 1, wherein the skin active ingredient is retinol, retinyl palmitate, adenosine and polyethoxyl etiretin amide; Arbutin, oil soluble licorice, ethyl ascorbyl, ascorbyl glucoside and magnesium ascorbyl phosphate; Chichi mushroom polysaccharide, niacinamide and N-acetylglucosamine; Ceramides, chamomile oils and oil-soluble soybeans; And caffeine, deanine and ferulina, wherein the cosmetic silicone gel patch is one or more selected from the group consisting of. The cosmetic silicone gel patch of claim 1, wherein the silicone pressure-sensitive adhesive layer comprising the skin active ingredient is applied on a support to a thickness of 0.001 cm to 2 cm. The cosmetic silicone gel patch of claim 1, wherein the support is a silicone film or a nonwoven fabric. The cosmetic silicone gel patch of claim 1, further comprising applying a release liner to a surface of the silicone adhesive layer including the skin active ingredient. 1) blending a skin active ingredient into a silicone part including a crosslinking site; 2) stirring the silicone part including the crosslinking catalyst with the compound of step 1); 3) applying the stirring solution of step 2) on a backing film; 4) aging the contents of step 3) to form a silicone gel having a silicone pressure-sensitive adhesive layer formed on the support; And 5) cutting and packaging the silicon gel formed in step 4) Method for producing a cosmetic silicone gel patch comprising a. The method of claim 7, wherein the silicone part including the crosslinking site is contained in an amount of 20.0 wt% to 60.0 wt% based on the total weight of the total composition of the patch. The method of claim 7, wherein the skin active ingredient is retinol, retinyl palmitate, adenosine and polyethoxyl thydretinamide; Arbutin, oil soluble licorice, ethyl ascorbyl, ascorbyl glucoside and magnesium ascorbyl phosphate; Chichi mushroom polysaccharide, niacinamide and N-acetylglucosamine; Ceramides, chamomile oils and oil-soluble soybeans; And caffeine, deanine, and ferulina. The method of manufacturing a cosmetic silicone gel patch, characterized in that at least one member selected from the group consisting of. According to claim 7, wherein the step of 1) The method for producing a cosmetic silicone gel patch, characterized in that it further comprises a silicone for viscosity control. The method of claim 10, wherein the viscosity-adjusting silicone is contained in an amount of up to 30.0% by weight based on the total weight of the total composition of the patch. The method of claim 7, wherein the silicone part including the crosslinking catalyst is contained in an amount of 20.0 wt% to 60.0 wt% based on the total weight of the total composition of the patch. 8. The method of claim 7, wherein the silicone pressure-sensitive adhesive layer containing the skin active ingredient is coated on a support with a thickness of 0.001 cm to 2 cm. 8. The method of claim 7, wherein the support is a silicone film or a nonwoven fabric. The method of claim 7, further comprising applying a release liner (Release Liner) on the surface of the silicone gel pressure-sensitive adhesive layer after the step 4).

Images