KR20040087006A - Seat-type hydrogel pack using water soluble polymer and the manufacturing process thereof - Google Patents

Abstract

PURPOSE: Provided are a seat-type hydrogel pack using at least one kind of water soluble polymer as a main ingredient and the manufacturing process thereof, thereby moisturizing the stratum corneum caused by dryness, ultraviolet rays, contamination and stresses. CONSTITUTION: The method for manufacturing a seat-type hydrogel pack is characterized by freeze-drying the component which contains at least one kind of water soluble polymers, the moisturizing agent and water, wherein the component further contains supplements and pH controlling agents; the pH value of the hydrogel pack is controlled to pH 4-8; and the water soluble polymers are selected from natural polymers, semi-synthetic polymers and synthetic polymers.

Description

Sheet-type hydrogel pack using water-soluble polymer and manufacturing method thereof {SEAT-TYPE HYDROGEL PACK USING WATER SOLUBLE POLYMER AND THE MANUFACTURING PROCESS THEREOF}

The present invention relates to a sheet-type hydrogel pack containing at least one water-soluble polymer as a main component and a method for producing the same.

A pack is originally a 'wrapping' meaning that wraps an active substance in the face to remove pores, cleans the skin and effectively supplies moisture and beauty ingredients to the skin to maintain blood circulation and restore skin physiology. It is a kind of cosmetics.

Since the pack can provide various nutrients to the skin very effectively, it can be expected to have various effects such as moisturizing, soothing, aging, removing dead skin cells and wastes, restoring tired skin, enhancing elasticity and whitening by these cosmetic ingredients. In addition, the pack can pull the skin as the membrane shrinks when the pack is dried to create a tension on the skin, as well as to improve the elasticity of the skin and relieve fine wrinkles by the adhesion and massage effect that appears when the membrane is peeled off.

In addition to the cosmetic and health effects described above, the psychological stabilizing effect can be alleviated by supplying a rest to the tired face and body with a comfortable mind for the time it takes to apply the pack to the skin and then dry it. You can expect

Packs are divided into peel-off packs, wash-off packs, and tissue-off packs, depending on the type. After elapsed, the dried film is peeled off and has a function of moisturizing, skin elasticity recovery, sebum and waste removal. The washoff type is a form in which a pack agent is applied to the face and then washed with water, and has functions such as moisturizing, soothing, fatigue recovery, and nourishment. Tissue-off packs are applied to the face by applying cream-type packs to the face, absorbing some of the pack's nutrients into the skin, and then wiping the remaining packs with a towel. Packs of nonwoven fabrics that are widely commercialized nowadays can also be seen as a kind of tissue-off packs, but they can be classified into independent forms as they are diversified.Non-woven fabric packs containing nutrients or wrinkle-reducing ingredients Many products have been applied to the entire face, around the eyes, or around the mouth, or applied separately.In addition, parts packs can be used to remove sebum, old dead skin cells and waste products by using it on the nose and around the sebaceous glands. It is becoming.

On the other hand, a large number of pores exist in the human skin, but keratin is formed in the pores by secretions such as oil or sebum secreted from the skin itself or dust by external environment. Since the formed keratin is not good for skin health and beauty, various methods are used to prevent or remove keratin. As a general method for preventing or removing keratin, a method of washing the skin using various cleansing agents or removing using various types of packs having the same effect is used. Facial cleansing with facial cleansing is effective in preventing keratinogenesis, but it is almost impossible to remove dead skin cells already formed in the pores. In addition, a method of using a liquid pack agent in a tube, which is a kind of peel-off type, is a method of removing keratin while peeling the formed coating from the skin by applying a liquid water-soluble pack agent to the skin and then leaving it to dry for a predetermined time. Since the method is also a method of removing dead skin cells in the pores by the adhesive force of the film generated when the film formed on the skin is peeled off from the skin, a sufficient exfoliation effect cannot be expected. Moreover, the method of using such a coating liquid pack agent is difficult for the user to apply a uniform thickness to his skin, so that the dry state of the film formed by leaving it for a certain time becomes uneven and partially does not dry completely. If the coating is peeled off from the skin, there is a problem that the pack agent may remain on the skin. In addition, the thin portion of the coating film applied to the skin is also easy to tear during peeling, there is a problem that takes a long time to remove the entire film because the fracture pieces remain in the skin. In order to solve such a problem, it is necessary to apply a thick pack and dry it for a longer time, but this method lacks simplicity and lacks practicality, and increases the consumption of the pack and is not economical.

Accordingly, the present inventors have developed a sheet-type pack agent which does not need to be washed with a simple sheet type and does not have to worry about the pack agent remaining on the skin even when peeled from the skin in order to overcome the problems of the pack agent used in the past.

Sheet-type pack of the present invention is a very effective product that can not only supply moisture and nutrients evenly throughout the face, but also intensively manage the skin drying within a short time of 15 to 30 minutes. In addition, the present inventors used water as a dispersion medium, and a part of the water molecule was hydrogen-bonded with the polar group of the chain-shaped molecule to use a hydrogel that surrounds the molecule in the form of a protective net as a pack. Hydrogels are water-free, non-sticky, swelled by water or other liquids, and have a certain degree of roughness. They are already used in semi-solid preparations. Formulations have been developed that enhance the moisturizing and nourishing or exfoliating effect of the pack.

The benefits of using a device containing patches, eg, water soluble polymerizable gel formers, in place of creams and lotions, etc. to cosmetically treat the skin or to facilitate the treatment of burns or wounds are known in the prior art. have. Various cosmetic patches or devices are commercially available or have been described as useful for the delivery of skin care actives such as vitamin actives, anti-wound actives, hydrating agents and the like. Patches and devices have been described in various literatures and are commercially available in the medical field as a useful means for transdermal administration of medicines.

In recent years, Japanese Patent Application Laid-Open No. 54-49334, a pack agent, discloses a low peeling pack agent having excellent water-retaining ability mainly containing polyacrylate, polyhydric alcohol and water. Japanese Unexamined Patent Publication No. 1-46485 discloses a sheet-like pack agent using a cross-linked hydrogel as a base, and Japanese Unexamined Patent Publication No. 5-295004 discloses a pack agent blended with a natural-derived semisynthetic component as a moisturizer and thickener. It is.

However, the conventional pack agent has a problem that the pack action is not sufficient, and a feeling of discomfort such as a feeling of pressure and tingling at the time of sticking is likely to occur, and even in the present day, which is called a sheet cosmetic boom, the user's relaxation requirements cannot be satisfied. There was no problem.

In addition, Japanese Patent Application Laid-Open No. 8-283147 discloses an aqueous pressure-sensitive adhesive composition which is durable when applied to the skin as an external preparation and gives a moderate level of cooling. However, the composition is used only as a component of an external preparation such as a poultice sheet, and has not been studied at all as being used as a component of a sheet-like pack agent.

Therefore, there is an urgent need for the development of a sheet-like pack agent having a pack action excellent in the effect and stability on the skin and excellent in the relaxation and relaxation of the mind and body without losing proper adhesiveness to the skin.

It is an object of the present invention to provide a sheet-type hydrogel pack agent comprising at least one water-soluble polymer having excellent exfoliation and moisture supply effects, and a method for producing the same.

The present invention further comprises a reinforcing agent and a pH adjusting agent in the preparation of the sheet-type pack by a process comprising lyophilization of at least one water-soluble polymer, a moisturizing agent, and a water-containing component, the pH of the hydrogel pack agent is 4 to 8 The manufacturing method of the sheet-type pack agent characterized by adjusting by the method and the sheet-type pack agent manufactured by the method are provided.

In the present invention, as the water-soluble polymer, at least one water-soluble polymer selected from natural polymer, semi-synthetic polymer and synthetic polymer is used as a raw material.

Natural polymers include gelatin, chitosan, hyaluronic acid or salts thereof, collagen, residue rubber, acacia rubber, collapsing rubber, carrageic acid, arginic acid, sodium arginate, agar, gum arabic, toragan rubber, karaya rubber, pectin and Starch and the like can be used.

As the semi-synthetic polymer, methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, sodium carboxymethyl cellulose, soluble starch, carboxymethyl starch and dialdehyde starch can be used, and synthetic polymers include polyvinyl alcohol, polyvinylpyrrolidone, Polyvinyl acrylate, polyacrylic acid, sodium polyacrylate, polyacrylic acid copolymer (such as carboxyvinyl poly), polyethylene oxide, methyl vinylether-dehydroxymaleic acid copolymer and isobutylene-maleic anhydride Phosphorus and the like can be used. Of course, the said water-soluble polymer includes the thing processed by the well-known crosslinking agent or a polymer.

The blending amount of the water-soluble polymer is preferably 1 to 50% by weight, more preferably 3 to 30% by weight, and particularly preferably 5 to 20% by weight based on the total amount of the dry pack agent (other than the moisture agent). In the formulation and ratio of the water-soluble polymer as described above, in particular, the maintenance and stability of the moisture content is improved, the adhesion to the dermal (skin) and the exfoliation performance is improved. In addition, it is possible to prevent sticking or sagging of the base, to relieve pain when peeling off the hydrogel pack from the skin, and to prevent the base from remaining on the skin.

As a moisturizing agent, all known moisturizing agents can be used, but preferably glycerin, propylene glycol, diethylene glycol, polyethylene glycol, polypropylene glycol, 1.3-butylene glycol, etc. may be used. It can mix and use. At this time, the blending amount of the moisturizer is preferably 3 to 60% by weight, more preferably 5 to 50% by weight, and even more preferably 10 to 45% by weight based on the total amount of the dry pack agent (except moisture). In this range, the hydrogel pack agent maintains a moderate wet state and improves sustained cooling and volatilization of moisture.

In addition, the amount of water indispensable as the hydrogel pack agent is preferably 10 to 80% by weight, more preferably 20 to 70% by weight, further preferably 25 to 65% by weight based on the total amount of the hydrogel pack agent. If the amount of water is too small, the stability, cooling effect and water supply ability of the hydrogel pack agent are lowered.

As the reinforcing agent, fillers such as kaolin, loess, charcoal, zinc oxide, titanium, talc, bentonite, hydrous aluminum silicate; Preservatives, such as thymol, methyl paraben, benzalkonium chloride, and ethyl paraben; Antioxidants such as ascorbic acid, stearic acid ester, etheric acid 2-sodium acid, dibutyl hydroxytoluene, butyl hydroxy aryl sol, and molar acid ester; Emulsifiers such as sorbitan fatty acid esters, glycerin fatty acid esters, polyethylene glycol fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylin alkyl ethers: phenyl salicylate, glycol salicylate, methyl paraaminobenzoate, 2-hydroxy-4- Ultraviolet absorbers such as methoxy benzophenol, 2.2'-dihydroxy-4.4'-dimethoxybenzophenone, and 2-hydroxy-4-methoxybenzophenol-5-sulfonic acid; Alkali supermetals such as calcium softened, calcium carbonate, magnesium chloride, aluminum compounds such as alum, ammonia alum, aluminum hydroxide, aldehydes such as formalin, glyoxazole, glutaraldehyde dialdehyde starch, epoxy compounds and isocyanates Crosslinking agents or polymers such as compounds; And tackifiers such as polybutene, natural latex, vinyl acetate emulsion, polyacrylic acid ester emulsion, and the like, and the various reinforcing agents may be suitably blended with one or more of them to improve the moisturizing and exfoliating ability of the hydrogel pack agent. . The various reinforcing agents are preferably 0.05% to 30% by weight based on the total amount of the dry pack agent.

As the pH adjuster, organic acids such as citric acid, tartaric acid, acetic acid, malic acid, succinic acid, citric acid, tartaric acid, and water-soluble organic amines such as triethanolamine, diisoprochanolamine and diethanolamine may be used. By adjusting the pH of the pack agent, preferably in the range of 4 to 8, the irritation to the skin can be alleviated, the moisture absorption to the transdermal and the stability of the base can be improved, and the stickiness can be maintained. The compounding quantity of such a pH adjuster is mix | blended suitably according to the pH concentration of a hydrogel pecking agent, and is used.

The hydrogel pack agent of the present invention can be prepared by mixing known excipients, irritants, drug supplements, and in particular various pharmaceutically active ingredients, cosmetic ingredients and the like as necessary.

On the other hand, the base layer is preferably provided with a predetermined breathability and flexibility (flexibility), for this purpose it was prepared using a lyophilization method.

The present invention is explained in more detail by the following examples, but the present invention is not limited to the examples.

Example

Example 1 Preparation of Gelatin Sheet Pack

(Gelatin solution production)

Solutions for the manufacture of gelatin sheet packs are based on gelatin (10% by weight), titanium (1% by weight) as a reinforcing agent, concentrated glycerin (0.1% by weight) as a moisturizer, sodium ether (0.5% by weight) as excipient, pH The solution was prepared under pH 5.6 using lactic acid as the regulator. Gelatin was added to the mixer with purified water and dissolved at 80 ° C. to prepare a uniform solution. The solution for preparing a pack was prepared by mixing and stirring a solution of glycerin, sodium ester acid, and lactic acid dissolved in the gelatin solution.

(Gelatin Sponge Manufacturer)

The solution for pack preparation obtained above was placed in a 100 x 100 x 20 mm plastic case and frozen in a freezer maintained at -5 ° C. The gel was lyophilized using the frozen solution and the plastic cathy using a cryogenic freeze dryer. Lyophilized sheets were cut and sized to 20 × 12 × 5 mm.

Example 2 Chitosan Sheet Pack

(Preparation of Chitosan Solution)

Chitosan 1g was added to 99g of purified water, and it stirred gently at room temperature. While stirring, 1 ml of lactic acid was added thereto, followed by stirring for 6 hours, thereby preparing a uniform chitosan solution.

(Chitosan sponge production)

The chitosan solution (1% by weight) obtained above is the main ingredient, concentrated glycerin (0.1% by weight) as a moisturizer, talc (1% by weight) as a reinforcing agent, sodium etherate (0.5% by weight) as an excipient, and lactic acid as a pH adjusting agent. To prepare a solution under pH 5.6.

The solution for pack preparation obtained above was placed in a 100 x 100 x 20 mm plastic case and frozen in a freezer maintained at -5 ° C. The gel was lyophilized using the frozen solution and the plastic cathy using a cryogenic freeze dryer. Lyophilized sheets were cut into 20 x 12 x 5 mm in size and commercialized.

Example 3 Preparation of Chitosan-Gelatic Sheet Pack

50 g each of the geltic solution prepared in Example 1 and the chitosan solution prepared in Example 2 were added to a mixer and stirred to obtain a uniform solution.

To the obtained solution, a solution was prepared at pH 5.6 using concentrated glycerin (0.1% by weight) as an auxiliary moisturizer, sodium etherate (0.5% by weight) as an excipient and lactic acid as a pH adjuster.

The solution for pack preparation obtained above was placed in a 100 x 100 x 20 mm plastic case and frozen in a freezer maintained at -5 ° C. The gel was lyophilized using a frozen solution and a plastic cake using a cryogenic freeze dryer. Lyophilized sheets were cut into 20 x 12 x 5 mm in size and commercialized.

Comparative Example 1

(Moisture supply effect)

In the screw mouth bottle of 5 mm diameter, the physiological formula was added until the concave-convex shape was obtained.

The gelatin sheet-like pack agent obtained in Example 1, the chitosan sheet-shaped pack agent obtained in Example 2, and the gelatin-chitosan sheet-shaped pack agent obtained in Example 3 were each cut out to have a diameter of 20 mm, and a Kimwipe (trade name) was attached to the back side. .

Each of the three sponges was placed at the entrance of the screw mouth with the Kim Wipes not attached. The time until the Kimwipers affixed to the back side was recorded and the results are shown in Table 1.

Example number Back reaching time of distilled water (sec) One 15 2 13 3 8

As shown in Table 1, it was found that the gelatin-chitosan mixed solution had a faster water supply effect, which is thought to be a result of the pore types generated by the different mixed solutions. It was confirmed that the 2 also has a relatively fast water supply effect.

The sheet-type hydrogel pack of the present invention contains a repair, softening and essence component, which exhibits excellent exfoliation and moisture supplying effect in a short adhesion time, and at the same time, there is almost no skin remaining in the pack when peeling from the skin. It has the advantage of saving time and effort, and can be very useful for moisturizing and exfoliating the stratum corneum formed by drying, ultraviolet rays, contamination and stress.

Claims (13)

In the preparation of the sheet-type packer by a process including lyophilization of the at least one water-soluble polymer, a moisturizer and a component containing water, further comprising a reinforcing agent and a pH adjusting agent, to adjust the pH of the hydrogel pack agent to 4 to 8 The manufacturing method of the sheet-type pack agent characterized by the above-mentioned. The method of claim 1, The water-soluble polymer is a production method, characterized in that at least one selected from natural polymers, semi-synthetic polymers and synthetic polymers. The method of claim 2, Natural polymers are gelatin, chitosan, hyaluronic acid or salts thereof, collagen, residue rubber, acacia rubber, collapsing rubber, carrageic acid, arginic acid, sodium arginate, agar, gum arabic, toragan rubber, karaya rubber, pectin and starch The production method characterized in that at least one selected from. The method of claim 2, The semi-synthetic polymer is at least one selected from methylcellulose, ethyl cellulose, hydroxyethyl cellulose, sodium carboxymethyl cellulose, soluble starch, carboxymethyl starch and dialdehyde starch. The method of claim 2, Synthetic polymers include polyvinyl alcohol, polyvinylpyrrolidone, polyvinyl acrylate, polyacrylic acid, sodium polyacrylate, polyacrylic acid copolymer, polyethylene oxide, methylvinylether-maleic anhydride copolymer and isobutylene-maleic anhydride copolymer A production method characterized in that at least one selected from coalescing. The method of claim 2, The water-soluble polymer is a production method characterized in that at least one selected from gelatin, chitosan, polyvinyl alcohol or sodium polyacrylate. The method of claim 2, The blending amount of the water-soluble polymer is 1 to 50% by weight based on the total amount of the dry pack agent. The method of claim 1, Moisturizing agent is characterized in that at least one selected from glycerin, propylene glycol, sorbitol, ethylene glycol, diethylene glycol, polyethylene glycol, polypropylene glycol and 1,3-butylene glycol. The method of claim 1, Formulation amount of the moisturizing agent is 3 to 60% by weight based on the total amount of the dry pack agent. The method of claim 1, The blending amount of water is 10 to 80% by weight based on the total amount of the pack agent. The method of claim 1, Enhancers include kaolin, loess, charcoal, zinc oxide, titanium, talc, bentonite, hydrous silicate, zimol, methylparaben, benzalkonium chloride, ethylparaben, ascorbic acid, stearic acid ester, ether ether 2-sodium, di Butyl hydroxy toluene, butyl hydroxy azole, molybdenum ester, sorbitan fatty acid ester, glycerin fatty acid ester, polyethylene glycol fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene alkyl ether, salicylate phenyl, salicylate glycol, paraamino Methyl benzoate, 2-hydroxy-4-methoxybenzophenol, 2.2'-dihydroxy-4.4'-dimethoxybenzophenone, 2-hydroxy-4-methoxybenzophenol-5-sulfonic acid, calcium softened, carbonic acid Aluminum compounds such as calcium, magnesium chloride, alum alum, ammonia alum, aluminum hydroxide, eggs such as formalin, glyoxazole, glutaraldehyde and dialdehyde starch Hi Drew, epoxy compound, isocyanate compound benzoate, polybutene, a method characterized by using a natural latex, at least one member selected from vinyl acetate emulsion and polyacrylic ester emulsion. The method of claim 1, The pH adjusting agent is at least one selected from citric acid, tartaric acid, acetic acid, malic acid, succinic acid, citric acid, organic acids of tartaric acid, triethanolamine, diisoprochanolamine and diethanolamine. Sheet-type hydrogel pack agent prepared by the method of claim 1.