KR20090091512A - Enteric-soluble granulation of cassia obtusifolia l. seeds and the composition for improving constipation containing the same - Google Patents

Abstract

An oral administering composition for constipation, which contains enteric-soluble granulation of Cassia obtusifolia L. seeds is provided to improve the absorption of the composition in the body. A method for manufacturing an enteric-soluble granulation of Cassia obtusifolia L. seeds comprises: a step of pulverizing Cassia obtusifolia L. seeds to 0.01~2.0mm; a step of mixing with yeast mixture; and a step of mixing the power of Cassia obtusifolia L. seeds with enteric-soluble formulation to granulate.

Description

Enteric-soluble granulation of Cassia obtusifolia L. seeds and the composition for improving constipation containing the same}

The present invention relates to an enteric tolerant powder granules and an oral administration composition for improving constipation containing the same, and more particularly, to finely grind the biodeterminant, and then to enzymatic treatment to improve the absorption in vivo to granulate it The present invention relates to an enteric granule powder granule having excellent palatability and excellent effect of constipation symptoms and to an oral administration composition for improving constipation by preparing an enteric granule which improves enteric delivery of an effective substance by treating an enteric substance in.

Modern man is increasing in various adult diseases due to the intake of instant foods, high-fat foods and lack of exercise. Among them, obesity and constipation are mild and early symptoms of adult disease, but are causing a number of other complications. Recently, as a preventive measure against such diseases, interest in prevention and treatment using natural food as well as simple exercise is increasing.

Constipation refers to a case in which stools are hard and dry compared to healthy times, and the number of bowel movements and the amount of stool is greatly reduced, resulting in discomfort or physiological disorders. In order to improve and treat these constipation symptoms, it is recommended to eat foods high in fiber, such as sweet potatoes, greenish green vegetables, konjac, fruits, and meats. It is very difficult for young women who have fewer occasions to eat these foods. Thus, the use of herbal and herbal medicines excellent in the treatment of constipation has increased the need for a product that can be easily consumed without side effects.

Cassia Tora L. has long been known to be effective in treating constipation as well as eye diseases such as decreased vision and night blindness when the eyes are red, swollen and sore by eliminating the heat in the liver and activating the peristalsis of the large intestine. come.

Therefore, the present inventors focused on researching herbal foods that can improve and prevent constipation, and as a result, natural herbal medicines, especially glitches, are pulverized into fine powder, and beta-bonded through enzyme treatment of alpha and beta bonds present in the raw materials. Can be effectively removed to increase the absorption rate in the body, and by treating the enteric material in the step of granulation, it is possible to obtain a more improved constipation improvement effect and palatability through the efficient delivery and action of the active ingredients present in the intestine in the intestine Discovered and completed the present invention.

Accordingly, it is an object of the present invention to provide an oral dosage composition for improving constipation with excellent constipation improvement effect and palatability by increasing the efficiency of delivery and bioavailability to the intestinal tract powder having an effect of improving constipation to the intestine.

In order to achieve the above object, in the present invention, the biodeterminant is finely divided into powder and then treated with enzyme to improve the absorption in vivo, and then the enteric material is treated in the step of granulating the enteric material to improve the enteric properties of the effective substance. Provided are granular powder granules and an oral dosage composition for improving constipation.

Oral administration composition for improving constipation according to the present invention was treated with enzymes in the powdered clarifier powder containing an active ingredient to increase the absorption in the body, by enteric granulation it was excellent in intestinal delivery and action effect of the components effective for improving constipation, Excellent palatability, it is useful for food and food manufacturing industry for constipation improvement. In addition, the synergistic effect and the improvement of palatability by mixing with other herbal medicine can be expected.

Hereinafter, the present invention will be described in more detail.

Cassia Tora L. used in the present invention, also known as ultra-low or horse-ear, has been used mainly in habitual constipation in oriental medicine and folk, and the seeds or leaves of the constipation (tong, 경), It has been used for the purpose of healthy stomach, strengthening eyesight, suit, diuresis, laxative, blue and blue nominal, rotatoral stool, target carcinoma and thermal constipation.

The preparation process of the enteric tolerant powder granules according to the present invention comprises the following steps:

1) pulverizing the deflector to 0.01 ~ 2.0mm to produce a deflector powder;

2) treating the enzyme mixture of the clarifier powder of step 1); And

3) granulating by mixing the clarifier powder prepared in step 2) with an enteric preparation.

Looking at the manufacturing process of the enteric colorant powder granules in more detail.

1) First, put the clarifier in the grinder and grind to 0.01 ~ 2.0mm size.

2) After treating the enzyme mixture to 0.1 ~ 10% by weight based on the total weight of the reactant to the gyeoljak powder adjusted to pH 4.0 ~ 6.0 using a pH adjuster, using a shaking incubator, 50 ~ 200rpm and After reacting for 1 to 4 hours at the conditions of 35 to 60 ℃, the reaction solution is evaporated. At this time, when the amount of the enzyme mixture used is less than 0.1% by weight, the reaction does not occur well, so that it is difficult to obtain a desired reaction result, and when it exceeds 10% by weight, the efficiency is inferior in terms of economy.

The enzyme mixture used here is a protease that helps break the binding of the hard cell wall. For example, Pectinase (Polygalacturonase) (Citrozym Cloudy 100L, Novozmes) can be used. It is possible to use a mixture of β-glucosidase as an enzyme that efficiently removes beta-bonded sugars using the loosened portions, but is not limited thereto.

In general, in the case of glycogen and cellulose, there are alpha type and beta type in which sugars are connected, but starch and glycogen have alpha bonds. Alpha-linked polysaccharides are broken down into glucose by enzymes in the body, which are useful in the body. On the other hand, cellulose or chitosan, which is beta-linked, does not contain normal enzymes that break down beta-bound polysaccharides. It does not decompose. However, because cows have microorganisms that release enzymes that can break down cellulose in the body's stomach, cellulose can be broken down and used in the body. In the present invention, substances that are considered to be effective ingredients of the deficiency used as active ingredients are also present in the form of a sugar-linked form. However, alpha-binding of these sugar-binding compounds is degraded in the body, but beta-binding is not so bioavailable. Therefore, in the present invention, by treating the enzymes to the deficiency powder to remove the beta-binding sugar to increase the utilization of the active ingredient in the body to increase the effect.

The pH adjusting agent used in the art can be easily selected and used by those skilled in the art commonly used in the art, for example, it is preferable to use hydroxypropyl methyl cellulose (Hydroxypropyl methylcellulose), but is not limited thereto. .

3) The enteric preparations having excellent solubility under alkaline conditions of the enzyme-treated deflector powder in step 2) are used in an amount of 0.01 to 10% by weight based on the total weight of the reactants. When the content of the enteric preparation is less than 0.01% by weight, it is difficult to form granules, and when the content of the enteric preparation is more than 10% by weight, the effect of the effective substance may be reduced because the granules are not hardened and effective decomposition is performed at an alkaline pH. Therefore, the enteric preparation of the above range and the crystallizer powder is mixed and granulated to a size of about 1 to 2 mm in diameter.

In the above, it is preferable to use hydroxypropyl methyl cellulose (Hydroxypropyl methylcellulose) as an enteric preparation to be used for granulating the glen powder, but is not limited thereto. The hydroxypropyl methyl cellulose used in the present invention is a kind of powdered powder binder used to granulate by combining the powder. The binder is not dissolved in acidic acidity but melts in medium / alkali condition, so that the acidic condition is obtained when it is ingested. It can pass through and melt in the intestine without melting in the stomach, making it suitable for forming enteric granules due to pH dependent solubility.

Enteric tolerant powder granules according to the present invention can maximize the efficacy of constipation improvement by facilitating intestinal delivery as well as enhancing the absorption of the active ingredients in the body.

The present invention relates to an oral administration composition for improving constipation containing 90 to 99.9% by weight of the enteric colorant powder granules relative to the total weight of the composition. The content of the deficiency in the powder granules is determined by the amount of the enteric preparation and the amount of the additive for flavor, and the intake of the deficiency is about 0.5 to 1 g.

Oral administration composition for improving constipation according to the present invention can be prepared by further mixing the other active ingredients or other additives commonly used in addition to the enteric defect powder granules, it is formulated in a conventional oral dosage composition formulation, for example , Granules, capsules, tablets and pills may be prepared, but is not limited thereto.

Hereinafter, the present invention will be described in detail with reference to Examples and Test Examples, but the scope of the present invention is not limited thereto.

Example 1

1) Manufacture of the deflector powder

After washing the commercially available commercially available commercially available pulverized fine grinding powder having a particle size of 0.01 ~ 2.0mm.

2) Enzyme Treatment on Declarator Powder

The crystallizer powder was mixed with water in a weight ratio of 1:10. For enzymatic treatment, β-glucosidase (Celluclast 1.5LFG, Novozymes) and pectinase (polygalacturonase) (Citrozym Cloudy 100L, Novozmes) were each treated with 0.5% by weight of the total weight of the reactants. The pH was adjusted to 4.0-6.0 using a pH adjuster and reacted for 4 hours under conditions of 50-200 rpm and a temperature of 35-60 ° C. using a shaking incubator. After the reaction was completed, the reaction solution was evaporated to prepare an enzyme-treated deflector powder.

3) Granulation of defector powder

The prepared enzyme-treated deflector pulverized powder was mixed with hydroxypropylmethylcellulose in a weight ratio of 95: 5 and granulated to a size of 1 to 2 mm using a conventional granulation technique that is commercially available. Content is 0.5 to 1.0 g).

[Comparative Example 1] Clarifier Crushed Powder

After washing the commercially available commercially available commercially available pulverized fine grinding powder having a particle size of 0.01 ~ 2.0mm.

Comparative Example 2 Enzyme Untreated Enteric Clearer Powder Granules

In Example 1, except that the step 2) of enzymatic treatment of the deficiency powder was omitted, the same procedure as in Example 1 was performed to prepare the enzyme-treated enteric insemination powder granules.

Test Example 1 Constipation Improvement Effect Experiment

The products prepared in Example 1 and Comparative Examples 1 and 2 were each drinked to 20 subjects with constipation symptoms (morning and evening twice a day, taking the same amount of deficiencies, for example, Example 1 And in the case of Comparative Example 2 was compared to determine the effect of improving constipation in accordance with the criteria described in Table 1 below after taking twice as Comparative Example 1, the results are shown in Table 2 below.

Item example Determination of improvement effect before and after drinking Defecation effect 0 points: The percentage of respondents who felt improvement was less than 10% 1: The percentage of respondents who felt improvement was 10% ~ 25% 2: The percentage of respondents who felt improvement was 25% ~ 40% 3 points: Improvement The percentage of respondents who felt the effect was 40% ~ 60% 4 points: The percentage of respondents who felt the improvement effect 60% ~ 80% 5 points: The percentage of the respondents who felt improvement effect 80% ~ 100% The percentage of respondents who felt constipation improvement was judged from 0 (small) to 5 (large).

Production Example Example 1 Comparative Example 1 Comparative Example 2 Defecation effect (average score) 5 2 3

As can be seen from the results of Table 2, Example 1 prepared by using the enzyme-treated clarifier powder into enteric granules, bowel powder compared to the clarifier powder powder of Comparative Example 1 and the unenzymatic clarifier powder pulverized powder of Comparative Example 2 Effect and constipation improvement effect was excellent.

Test Example 2 Palatability Experiment

The palatability of Example 1 and Comparative Example 1 was evaluated for 10 sensory test personnel, the results are shown in Table 3 below.

Sensory tester One 2 3 4 5 6 7 8 9 10 Average Stomach irritation Example 1 5 4 5 5 4 4 5 5 5 5 4.7 Comparative Example 1 One 2 2 2 One 2 3 2 2 3 2.0 smell Example 1 4 4 4 3 4 3 4 5 3 4 3.8 Comparative Example 1 One One 2 One One 2 One One 2 One 1.3 flavor Example 1 4 3 4 4 3 4 4 3 5 4 3.8 Comparative Example 1 One 2 One One 2 One One One 2 One 1.3 Overall preference Example 1 5 5 5 4 5 5 4 4 4 5 4.6 Comparative Example 1 One 2 One One 2 One One One One 2 1.3 [Evaluation Criteria] 5: None, 4: Slight, 3: Normal, 2: Severe, 1: Very Severe (Smell, taste, whole)

As shown in the results of Table 3, in the case of the pulverized powder of Comparative Example 1, it was confirmed that the degree of preference decreases due to dissatisfaction with pain, smell and taste caused by the above irritation. On the other hand, it was confirmed that the enteric defect deterrent powder granules of Example 1 according to the present invention was excellent in the satisfaction of sensory test personnel.

Claims (7)

1) pulverizing the deflector to 0.01 ~ 2.0mm to produce a deflector powder; 2) treating the enzyme mixture of the clarifier powder of step 1); And 3) mixing the granulator powder prepared in step 2) with an enteric preparation and granulating it; Enteric tolerant powder granules manufacturing method comprising a. The method of claim 1, wherein the enzyme mixture of step 2) is 0.1 to 10% by weight based on the total weight of the reactants. The method of claim 1, wherein the enzyme mixture of step 2) is a method for producing enteric deficient powder granules, characterized in that the mixture of pectinase and β-glucosidase. The method of claim 1, wherein the enteric preparation of step 3) is used in an amount of 0.01 to 10% by weight based on the total weight of the reactants. The method of claim 1, wherein the enteric preparation used in step 3) is hydroxypropylmethylcellulose. An enteric tolerant powder granule produced by the manufacturing method according to any one of claims 1 to 5. A composition for improving constipation comprising the enteric tolerant powder granules of claim 6.