KR20090085806A - 지방기원 중간엽 줄기세포를 연골세포로 분화시키는 방법 - Google Patents
지방기원 중간엽 줄기세포를 연골세포로 분화시키는 방법 Download PDFInfo
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- KR20090085806A KR20090085806A KR1020080011645A KR20080011645A KR20090085806A KR 20090085806 A KR20090085806 A KR 20090085806A KR 1020080011645 A KR1020080011645 A KR 1020080011645A KR 20080011645 A KR20080011645 A KR 20080011645A KR 20090085806 A KR20090085806 A KR 20090085806A
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- stem cells
- mesenchymal stem
- bmp
- cartilage
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0655—Chondrocytes; Cartilage
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
- C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
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- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
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- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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Abstract
Description
Claims (7)
- 뼈형성단백질-2(BMP-2) 또는 뼈형성단백질-7(BMP-7)이 80 ~ 500 ng/㎖ 첨가된 연골형성 배지에서 배양하는 것을 특징으로 하는 지방기원 중간엽 줄기세포를 연골세포로 분화시키는 방법.
- 제1항에 있어서,상기 연골형성 배지에 전환성장인자-베타2(TGF-β2)를 추가로 포함시키는 것을 특징으로 하는 지방기원 중간엽 줄기세포를 연골세포로 분화시키는 방법.
- 제1항에 있어서,뼈형성단백질-7(BMP-7)이 80 ~ 500 ng/㎖ 및 TGF-β2가 2 ~ 20 ng/㎖ 첨가된 연골형성 배지에서 배양하는 것을 특징으로 하는 지방기원 중간엽 줄기세포를 연골세포로 분화시키는 방법.
- 제1항 내지 제3항 중 어느 하나의 방법을 통해 분화된 연골세포를 함유하는 연골손상 질환 치료용 조성물.
- 제4항에 있어서, 상기 연골손상 질환은 퇴행성 관절염 또는 류마티스성 관절염인 것을 특징으로 하는 조성물.
- 제1항 내지 제3항 중 어느 하나의 방법으로 분화된 연골세포를 사용하는 것을 특징으로 하는 인공관절의 제조방법.
- 제6항의 방법으로 제조되는 것을 특징으로 하는 인공관절.
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Application Number | Priority Date | Filing Date | Title |
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KR1020080011645A KR101012869B1 (ko) | 2008-02-05 | 2008-02-05 | 지방기원 중간엽 줄기세포를 연골세포로 분화시키는 방법 |
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KR1020080011645A KR101012869B1 (ko) | 2008-02-05 | 2008-02-05 | 지방기원 중간엽 줄기세포를 연골세포로 분화시키는 방법 |
Publications (2)
Publication Number | Publication Date |
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KR20090085806A true KR20090085806A (ko) | 2009-08-10 |
KR101012869B1 KR101012869B1 (ko) | 2011-02-08 |
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KR1020080011645A KR101012869B1 (ko) | 2008-02-05 | 2008-02-05 | 지방기원 중간엽 줄기세포를 연골세포로 분화시키는 방법 |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101362639B1 (ko) * | 2010-09-16 | 2014-02-13 | 연세대학교 산학협력단 | 중간엽 줄기세포의 연골 세포로의 분화 유도를 위한 화합물의 용도 |
CN113454206A (zh) * | 2018-09-28 | 2021-09-28 | 希拉生物股份有限公司 | 滑膜来源间充质干细胞及其用途 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101385851A (zh) * | 1999-02-01 | 2009-03-18 | 遗传研究所公司 | 用于关节软骨愈合和修复的方法和组合物 |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101362639B1 (ko) * | 2010-09-16 | 2014-02-13 | 연세대학교 산학협력단 | 중간엽 줄기세포의 연골 세포로의 분화 유도를 위한 화합물의 용도 |
CN113454206A (zh) * | 2018-09-28 | 2021-09-28 | 希拉生物股份有限公司 | 滑膜来源间充质干细胞及其用途 |
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KR101012869B1 (ko) | 2011-02-08 |
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