KR20090039267A - A composition using the hair containing thujopsis dolobrata oil - Google Patents

Abstract

A composition for hair containing Thujopsis dolabrata oil is provided to treat or prevent dandruff by inhibiting growth of Pityrosporum Ovale and reduce side effect caused by long term use. Thujopsis dolabrata is well known for the effect of sterilization, deodorization, skin care, circulation, and prevention of cough. Among various plant extracts, the Thujopsis dolabrata has a strong effect on anti-fungal activity. A composition for hair inhibiting Malassezia globosa comprises 0.1-20% by weight of Thujopsis dolabrata oil inhibiting growth of Pityrosporum Ovale. The composition for hair is formed with shampoo, rinse, aerosol spray, hair styling gel, hair tonic or soap.

Description

A composition using the hair containing Thujopsis dolobrata oil}

The present invention relates to a composition for hair containing Nahanbaek oil, and more particularly, has a growth inhibitory ability of Pyrosporum Ovale, which is the main cause of dandruff, shampoo, By using a composition for hair such as rinse, aerosol spray, hair styling gel, hair tonic, or soap, it treats or prevents dandruff, and contains Nahanbaek oil that can suppress the side effects of human body by using existing antibiotics. It relates to a composition for hair.

In general, dandruff refers to the stratum corneum-like mass formed by the dead or peeled cells of the scalp caused by the active metabolism of the human body with the secretion of the scalp sebaceous glands. Dandruff gradually has a clear border with normal skin, becomes red, and increases the scale of the scalp, which usually leads to seborrheic dermatitis with itching and inflammation.

The root cause of such severe dandruff is the state of uncertainty, but in general, endocrine hormone imbalance, nutritional metabolism, neurological factors such as stress, epithelial tissue biochemical changes due to excessive proliferation of scalp cells It is known to be caused by a combination of factors, such as the growth and activity of scalp microorganisms, and inflammation caused by air pollution.

In particular, the proliferation and activity of microorganisms called Pityrosporum Ovale, which are present in unclean scalp, have been recognized for a long time as a major factor for worsening dandruff and itching, and are widely accepted in recent years.

Therefore, in the case of hair cosmetics having a dandruff inhibitory action for the purpose of treating and preventing dandruff and itching, it effectively inhibits the growth and activity of the microbial phytirosporum obale which is the main cause of dandruff and prevents abnormal metabolic activity of the scalp cells. It is essential to contain a component that can be normalized.

Thus, as an example of the hair cosmetic composition aimed at suppressing dandruff and itching, the hair cosmetic composition containing zinc pyrithione (zinc-2-pyridinezol-1-oxide) as an active ingredient is mentioned. (US Pat. No. 2,809,971, US Pat. No. 4,323,683, US Pat. No. 4,345,080, US Pat. No. 4,470,982, and European Patent No. 285,388.) However, zinc pyrithione has a solubility that is only 15 ppm in water at 25 ° C. It is a water-insoluble solid particle having a spherical shape of about 1 μm having a very low limit. It is separated from the hair cosmetic composition, especially a shampoo composition, which mainly consists of water-soluble substrates, causing sedimentation by precipitation and the like. As a matter of stability, its content is regulated by the domestic market and the US Food and Drug Adminstration (FDA).

Dandruff is a type of seborrhoeic dermatitis in the scalp, which occurs mainly on the face, head, armpits, and genital areas where sebaceous glands are actively active, and occurs immediately after birth or after puberty.

Recently, it has been known that the causative agent of dandruff is yeast, and interest has recently increased due to the discovery of a fungus called yeast Pyrosporum ovale or Malassezia furfur (Kane J. Summerbell RC). Trichophyton, Microsporum, Epidermophyton, and agents of superficial mycoses.1999.In: Murray PR, Barron EJ, Pfaller MA, Tenover FC, Yolken RH (Eds.), Manual of Clinical Microbiology, 7 th ed., American Society for Microbiology Press, Washington, DC. Pp. 1275-1294).

Pytyrosporum obale or Malassezia puffer is a normal fungus that lives on the scalp (Roberts SOB. 1969. Pityrosporum orbiculare: incidence and distribution in clinically normal skin.British Journal of Dermatology 81: 246). It is found in about the same number in people who do not. It is believed that dandruff is caused by differences in susceptibility to dandruff (Bergbrant IM. 1995. Seborrhoeic dermatitis and Pityrospotum yeasts. Current Topics in Medical Mycology 6: 95-112).

As anti-dandruff drugs, new antimicrobials have been developed in the past decades and appear in the world market. Among them, ketoconazole has proven to be very effective in the treatment of pityriasis versicolor or dandruff (Rausch LJ, Jacobs PH. 1984. Cutis 34: 470-471; Hay RJ, Midgeley G. 1984. Clinical and Experimental Dermatology 9: 571-573; Savin RC. 1984. Journal of the American Academy of Dermatology 10: 824-830).

Although ketoconazole is currently used as an active ingredient in the treatment of dandruff, there is a problem that can cause adverse effects on the endocrine system if ketoconazole is used for a long time (Schuermeyer T, Nieschlag E. 1982. Ketoconazole induced drop in serum and saliva testosterone. Lancet 1098p; Janssen PAJ, Symoens JE. 1983. American Journal of Medicine 74: 80-85)

In addition, itraconazole was newly synthesized through research to develop an antibacterial agent that is safer than a ketoconazole but is safer for the human body. Itriazole derivatives have been found to be very effective against many pathogenic fungi associated with humans and have a high affinity for keratinous tissue (Van Cutsem J, Van Gerven F, Zaman R, Heeres J, Hanssen PAJ. 1983. Pharmacological and preclinical results with a new oral and topical broad spectrum antifungal R 51211. Proceedings of the 13 th International Congress of Chemotherapy, Vienna, Part 40: 1-11). Itraconazole inhibits ergosterol synthesis and acts as a mechanism of binding to P450, a fungal oxidase system that causes membrane function and membrane permeability abnormalities (Grant SM, Clissold SP. 1989. Drugs 37: 310-344).

However, because itraconazole is not transported through sweat glands like ketoconazole, it has a disadvantage of slow transportation when taken with oral preparations, and it is reported that at least 1,000 mg of prescription is required daily to prevent satisfactory treatment and recurrence. SM, Clissold SP. 1989. Drugs 37: 310-344). In addition, although most patients are prescribed several kinds of medications at the same time, a combination of medications can cause problems with hepatotoxicity, which can affect the immune system and increase the effectiveness or adverse effects of a drug ( Svejgaard E. 1995. Side effects and interactions of oral antifungals.Journal of the European Academy of Dermatology and Venereology 5, page S11; Bickers DR. 1994. Journal of the American Academy of Dermatology 31: S87-S90), with headaches or nausea. It also causes the same symptoms (Georgiou S, Monastirli A, Pasmatzi E, Zografakis C, Tsambaos D. 1997. Oral itraconazole therapy for pityriasis versicolor. Journal of the European Academy of Dermatology and Venereology 8: 203-207).

On the other hand, the ingredients mainly used in anti-dandruff shampoo or lotion are selenium sulfide or zinc pyrithion.

Dandruff is not a shortened or serious illness, but it is a psychological stress for most people. Methods and ingredients to prevent or treat such dandruff are continuously being studied, but the results of studies on ingredients that can be ecologically friendly, harmless to the environment and human beings, and bring about a reduction in the number of dandruff bacteria are still inadequate.

As described above, various researches and efforts have been made on the treatment of dandruff bacteria to date, and the present inventors have been studying for many years to separate antimicrobial substances from various compounds or natural products. The present invention was completed by confirming that Nahanbaek oil extracted from Nahubaek (Thujopsis dolabrata) tree, which is renowned as three major forests in Japan, is active against antidandruff.

The present inventors have conducted a lot of research to develop a cosmetic that can improve as well as prevent dandruff, Nahanbaek oil has antibacterial effects on Pytirosporum Ovale, the main cause of dandruff, and using dandruff The present invention was found to be effective in the improvement and prevention of the present invention.

Therefore, the present invention has been made to solve the above problems, the object of the present invention can provide a composition for hair containing Nahanbaek oil that is effective in preventing and improving dandruff containing Nahanbaek oil.

According to a feature of the present invention for achieving the above object, in the anti-dandruff inhibiting composition, by using the anti-microbial agent used as an anti-microbial agent that can prevent or treat dandruff by inhibiting the growth of Pyrosporum Ovale (Pityrosporum Ovale) It provides a hair composition comprising.

At this time, according to an additional feature of the present invention, it is preferable to contain 0.1 to 20% by weight based on the total weight of the composition as the active ingredient of the cold white oil.

In addition, according to an additional feature of the present invention, the hair composition is preferably composed of a mixture of shampoo, rinse, aerosol spray, hair styling gel, hair tonic, or soap.

The composition for hair containing Nahanbaek oil according to the present invention is a shampoo, rinse, aerosol spray, hair styling gel, using Nahanbaek oil having antifungal activity against Pyrosporum Ovale, the main cause of dandruff. Hair tonic or hair composition such as soap is effective for treating or preventing dandruff.

In addition, by using Nahanbaek oil extracted from Nahanbaek tree, which inhibits the growth of P.ovale, the main cause of dandruff, in hair composition, it causes side effects of human body called resistance due to the use of antibiotics. It can be suppressed and a composition for safe dandruff treatment and prevention can be provided.

In the present invention can be used as an active ingredient of the composition for hair containing Nahanbaek oil, preferably the strong aroma of Nahanbaek is known to be effective in sterilization, deodorization, skin care, blood circulation, cold and blood It promotes circulation and metabolism, produces efficacy such as forest bath, and is known to have mysterious effects on fatigue and longevity, and does not cause side effects from long-term use. The hair composition containing the Nahanbaek oil extracted from Nahanbaek contains shampoo, rinse, aerosol spray, hair styling gel, hair tonic, or soap.

Hereinafter, the present invention will be described in detail.

The present inventors studied various plant extracts in order to search for a substance to prevent dandruff. As a result, the inventors found Nahanbaek oil having strong antifungal action against dandruff among various natural products, thereby completing the present invention.

As described above, Nahanbaek oil is very effective in anti-dandruff hair composition because of its high antifungal activity against dandruff. Accordingly, the present invention relates to an anti-dandruff hair composition comprising Nahanbaek oil, which is effective in preventing and treating dandruff.

  In addition, the hair composition is used for the hair, it can be prepared in the form of a conventional hair, such as shampoo, rinse, aerosol spray, hair styling gel, hair tonic, or soap.

Hereinafter, exemplary embodiments of the present invention will be described in detail with reference to the accompanying drawings.

Figure 1 is a culture photograph of the concentration-dependent anti-dandruff activity against the dandruff bacteria (P. ovale) of Nahanbaek oil according to the present invention, Figure 2 is a concentration for the dandruff bacteria (P. ovale) of Nahanbaek oil according to the present invention Figure 3 is a graph showing the anti-dandruff activity, Figure 3 is a culture photograph of the antifungal activity against the control Itraconazole (P. ovale), Figure 4 is a control Itraconazole (P. ovale) to the control Itraconazole (Itraconazole) Figure 5 is a graph showing the antifungal activity, Figure 5 is a culture photograph showing the concentration-dependent antifungal activity in hair products containing 2% Ketoconazole (Ketoconazole) control of dandruff (P. ovale), Figure 6 is a dandruff (P. A graph of concentration-dependent antifungal activity is shown for hair products containing 2% of ketoconazole, the control of ovale.

In order to reduce the side effects and resistance of hormones, antibiotics, and synthetic drugs that have been used as anti-dandruff drugs, and to develop anti-dandruff preventive and improved treatments with harmless natural products, it is known that Pyrosporum ovale, the main cause of dandruff, is developed. Antimicrobial activity was tested.

Antibacterial activity test against dandruff bacteria of Nahanbaek oil of the present invention was measured using Pytirosporum ovale KCTC 7546. P.ovale was distributed by the Korean Collection for Type Cultures, and was prepared and cultured in the provided medium composition. Pytirosporum ovale medium was modified LNA with a composition of 50.0 g malt extract agar, 20 g glucose, 1 g polypeptone, 20.0 g bile salts, Tween 40 1%, and glycerol 0.2% , agar 2%, which was dissolved in 1.0 L of distilled water, and inoculated with dandruff in a solid medium prepared by sterilization.

Example 1

Growth inhibition activity was assayed by the paper disc diffusion method. 5 μl of the Hanbaek white oil, or the control, was dissolved and treated at about 6 mm in diameter, and the solvent was volatilized in the hood for 5 minutes. Each treated place was placed on a medium inoculated with phytirosporum obale and exhaled incubated at 28 ° C. for 3 days, and the antibacterial activity was confirmed by looking at the size of the clear zone formed around the place.

As a result, it can be seen that Nahanbaek oil has a concentration-dependent antifungal effect on the test strain of Pytirosporum ovale diluted 1/5 by ethanol from the stock solution. In particular, as shown in Figure 1 Thujopsis dolobrata oil can be seen that the clear zone is formed in Pyrosporum ovale (Pityrosporum ovale) and the clear zone measurement values are shown in Table 1.

TABLE 1

Nahanbaek Oil (ppm) One 2 3 4 Dilution solution Remarks crude 200,000 40,000 8,000  ethanol See Figure 2 clear zone (mm) 38 ± 1.5 23.3 ± 2.5 15 ± 1 7.3 ± 0..6

- error correcting capability of Ross Forum Ovalle clear zone (inhibitory ring) for the antifungal activity of the oil or Hanbaek (Thujopsis dolobrata) to (Pityrosporum ovale) measurements

Example 2

Under the same environmental conditions as in the test method of Example 1, antifungal activity against itraconazole and ketoconazole having activity against the main causative agent of dandruff was tested as a control of the Nahanbaek oil.

The itraconazole (Itraconazole) was experimented with chloroform under the solvent condition and the ketoconazole (ketoconazole) was used by diluting the hair product containing ketoconazole 2% as shown in Figures 3 and 5 itraconazole (ketraconazole), ketoconazole (ketoconazole) also The antifungal activity of Pyrosporum ovale, the main cause of dandruff, can be confirmed.

TABLE 2

Itraconazole (ppm) One 2 3 4 Dilution solution Remarks 100,000 20,000 4,000 800  chloroform See Figure 4 clear zone (mm) 18.3 ± 0.6 18.3 ± 0.6 16.3 ± 1.5 16 ± 1.7

- error correcting capability of Ross Forum Ovalle clear zone (inhibitory ring) for the antifungal activity of itraconazole for (Pityrosporum ovale) measurements

TABLE 3

ketoconazole (ppm) One 2 3 4 Dilution solution Remarks 2,000 400 80 16 distilled H ₂ O See Figure 6 clear zone (mm) 24.3 ± 0.6 18 ± 1 10.6 ± 1.5 7 ± 0

- error correcting capability of Ross Forum Ovalle clear zone (inhibitory ring) for the antifungal activity conducted by a hair product containing ketoconazole 2% for (Pityrosporum ovale) measurements

That is, according to the above Example 2, compared to the case of itraconazole (itraconazole) synthesized by supplementing the shortcomings of ketoconazole as a control of Nahanbaek oil, but itraconazole almost up to 4,000 ppm The same or similar activity was observed and the activity decreased from below 800 ppm. Chloroform had no effect on antifungal activity and showed a concentration-independent antifungal activity that showed an even overall activity.

TABLE 4

Na-baek oil (ppm) One 2 3 4 Dilution solution Remarks crude 200,000 40,000 8,000  ethanol See Figure 2 clear zone (mm) 38 ± 1.5 23.3 ± 2.5 15 ± 1 7.3 ± 0.6 Itraconazole (ppm) One 2 3 4 Dilution solution Remarks 100,000 20,000 4,000 800  chloroform See Figure 4 clear zone (mm) 18.3 ± 0.6 18.3 ± 0.6 16.3 ± 1.5 16 ± 1.7 ketoconazole (ppm) One 2 3 4 Dilution solution Remarks 2,000 400 80 16 distilled H ₂ O See Figure 6 clear zone (mm) 24.3 ± 0.6 18 ± 1 10.6 ± 1.5 7 ± 0

As a result, hair products containing 2% ketoconazole used as a control in the antifungal activity of the causative strain (P.ovale) of the dandruff run with the Nahanbaek oil of the present invention as shown in Table 4 above. The results show that the antifungal activity against dandruff is comparable to that of itraconazole.

In other words, ketoconazole as an antimicrobial agent generally used for the treatment of dandruff has been proved to be very effective in the treatment of pityriasis versicolor or dandruff. Although ketoconazole is used as an active ingredient in dandruff treatments in Korea, it has been raised a problem that can cause adverse effects on the endocrine system if ketoconazole is used for a long time, and itraconazole derivatives, known as safer antibacterial agents than human ketoconazole, It has been found to be very effective against many of the pathogenic fungi involved and has a high affinity for keratinous tissue.

Itraconazole inhibits the synthesis of ergosterol and acts as a mechanism of binding to P450, a fungal oxidase system that causes membrane function and membrane permeability abnormalities. Research has shown that it can affect toxicity and immune system, cause problems that can increase the effectiveness or adverse effects of a drug, and cause symptoms such as headaches and nausea.

As described above, the Nahanbaek oil of the present invention exhibits lower antifungal activity than the test subject or itraconazole of hair products containing ketoconazole (2%), but is extracted from Nahanberry as a result of the use of conventional antibiotics. It can be used as an anti-dandruff therapeutic composition in that it is safe without causing side effects of the human body.

Nahanbaek oil as described above is a mixture of shampoo, rinse, aerosol spray, hair styling gel, hair tonic, or soap that can be applied to the hair which is the main source of dandruff for hair including the hanbaek oil according to the present invention It can be prepared in a composition, which can be made by configuring the hanbaek oil 0.1% to 20% by weight in the composition of the conventional anti-dandruff hair composition.

Hereinafter, as an example of the formulation of the present invention, shampoos, rinses, aerosol sprays, hair styling gels, hair tonics, and soaps are exemplified, but formulations including the composition for hair of the present invention are not limited thereto.

Formulation Example 1. Soap

In order to produce soap for the treatment and prevention of dandruff containing the Nahanbaek oil of the present invention, it may be prepared according to a manufacturing method in a conventional soap manufacturing field as described in Table 5 below.

TABLE 5

Ingredient Content (% by weight) Nahanbaek oil 0.1 to 20% Purified water 2 % Tricholic acid 2 % Mineral oil One % Polyethylene glycol 0.5% Spices 0.1% Tribromsala 0.1% Hexachlorophene 0.1% Ethylenediamine Acetate 0.1% Titanium dioxide 0.1% Soap base up to 100% Sum 100

Formulation Example 2. Aerosol Spray

In order to produce an aerosol spray for the treatment and prevention of dandruff containing the hanbaek oil of the present invention, it can be prepared according to the preparation method in the conventional aerosol spray manufacturing field as described in Table 6 below.

TABLE 6

Ingredient Content (% by weight) Nahanbaek oil 0.1 to 20% Purified water 20.0% Surfactants 0.1% or more Alkali metal benzoate 0.01% or more Hydrocarbon Gas Propellant up to 100% Sum 100

Formulation 3. Shampoo

To prepare a shampoo for the treatment and prevention of dandruff including the Nahanbaek oil of the present invention, it can be formulated according to the preparation method in the conventional shampoo field as shown in Table 7 below.

TABLE 7

ingredient Content (% by weight) Nahanbaek oil 0.1 to 20% Sodium Lauring Sulfate 20.0 Sodium polyoxyethylene lauryl sulfate 15.0 Palm oil fatty acid diethanolamide 5.0 Polyquaternium 0.3 Propylene glycol 2.0 Pyrotonolamine 0.5 Paraoxybenzoic Acid Ester 0.2 Combination Quantity Citric acid Quantity Purified water To 100

Formulation Example 4. Hair Conditioner

To prepare a hair conditioner for the treatment and prevention of dandruff comprising the Nahanbaek oil of the present invention, it can be prepared according to the preparation method in the field of conventional hair conditioner by combining as shown in Table 8.

TABLE 8

ingredient Content (% by weight) Nahanbaek oil 0.1 to 20% Cetyltrimethylammonium Chloride 7.0 Distearyl dimethylammonium chloride 4.0 Cetostearyl acol 3.5 Polyoxyethylene Steyl Ether 1.0 Liquid paraffin 2.0 Propylene glycol 1,5 Combination Quantity Citric acid Quantity Purified water To 100

Formulation Example 5. Hair Styling Gel

To prepare a hair styling gel for the treatment and prevention of dandruff containing the Nahanbaek oil of the present invention can be prepared according to a conventional manufacturing method by combining as described in Table 9.

TABLE 9

ingredient Content (% by weight) Nahanbaek oil 0.1 to 20% Carboxy Vinyl Polymer 0.6 Triethanolamine 0.65 Polyvinylpyrrolidone 2.0 Propylene Glydon 2.0 Ethylenediaminetetrasodium acetate 0.1 Benzophenone 0.05 Polyoxyethylene Cured Castor Oil 1.5 Combination Hostility ethanol 20.0 Purified water To 100

Formulation Example 6. Hair Tonic

In order to produce hair tonic for the treatment and prevention of dandruff containing the Nahanbaek oil of the present invention, it can be formulated according to a conventional manufacturing method by combining as described in Table 10 below.

TABLE 10

ingredient Content (% by weight) Nahanbaek oil 0.1 to 20% l-menthol 0.1 D-panthenol 0.6 Salicylic acid 0.05 glycerin 1.0 Polyoxyethylene Cured Castor Oil 0.8 Tocopherol Acetate 0.03 Combination Quantity ethanol 30.0 Purified water To 100

The present invention is not limited to the embodiments described above, and various modifications and changes can be made by those skilled in the art, which are included in the spirit and scope of the present invention as defined in the appended claims.

Figure 1 is a culture photograph showing the concentration-dependent anti-dandruff activity against dandruff (P. ovale) of Nahanbaek oil according to the present invention

Figure 2 is a graph showing the concentration-dependent anti-dandruff activity against dandruff (P. ovale) of Nahanbaek oil according to the present invention

Figure 3 is a culture photograph showing the antifungal activity of the control itraconazole (P. ovale) of the control itraconazole (Itraconazole)

4 is a graph showing the antifungal activity of the control itraconazole of P. ovale (P. ovale)

Figure 5 is a culture photograph showing the concentration-dependent antifungal activity in hair products containing 2% of ketoconazole (P. ovale) control ketoconazole

6 is a graph showing concentration-dependent antifungal activity in hair products containing 2% of ketoconazole, a control group of P. ovale.

Claims (3)

In the dandruff inhibitor composition, A composition for hair comprising Nahanbaek oil, which is used as an antimicrobial agent capable of preventing or treating dandruff by inhibiting the growth of Pytyrosporum ovale. The method of claim 1, The composition for hair, including the hanbaek oil, characterized in that containing 0.1 to 20% by weight relative to the total weight of the composition as the active ingredient of the hanbaekbaek oil. The method according to claim 1 or 2, The composition for hair is a composition for a hair comprising a cold hanbaek oil, characterized in that a mixture of shampoo, rinse, aerosol spray, hair styling gel, hair tonic, or soap.

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