KR20090035929A - Pastes for improving tooth using micro hydroxyapatite powders - Google Patents

Abstract

Tooth improving paste using hydroxyapatite powder with excellent bio-compatibility is provided to give polishability to a surface of teeth without enamel damage and remove causative bacterium of decayed teeth. Tooth improving paste using hydroxyapatite powder with excellent bio-compatibility comprises 100 parts of hydroxyapatite powder, 80-100 parts of precipitated calcium carbonate, 5-15 parts of sodium chloride, 120-180 parts of silicon dioxide and 5-10 parts of sodium monofluorophosphate by weight. The Tooth improving paste using hydroxyapatite powder with excellent bio-compatibility additionally contains 200-300 parts of purified water and co-additives. A particle size of the hydroxyapatite powder is 200(<=75mum)-635mesh(<=20mum).

Description

Paste for improving tooth using micro hydroxyapatite powders

The present invention relates to a tooth improver using hydroxide apatite powder, characterized by excellent effects such as improving microdefects of the tooth, whitening effect, and elimination of the causative agent by using microhydrapatite powder having excellent biocompatibility. will be.

Common conventional toothpastes are those that merely provide a tooth cleaning function. Its components consist of benzyl chloride, abrasives, and fluorine.The conventional toothpaste contains toothpaste in order to protect the gums and diseases, and to protect the teeth and the gums simultaneously. Attempts have been made to obtain a disease prevention effect, but in fact, even if used for a long time, the expected effect is hardly achieved, and in the case of a disease in the teeth or gums, a therapeutic effect could not be expected.

In order to solve the above problems, the present inventor has filed a patent application of Korean Patent Application No. 2004-54450 with respect to a powdered tooth improving agent mainly composed of apatite hydroxide, but in the case of the above patents, 75 to 85% by weight of hydroxide A powdered tooth improver consisting only of apatite powder, 15-20% by weight of edible peppermint powder and 4-5% by weight of blowing agent powder. Hydroxyapatite powder coats the surface of the damaged tooth with the main component of the tooth and bone. Although it is excellent in giving gloss, and whitening effect and removing the causative bacteria, tooth improver is composed of powder only, so that when brushing teeth, powdered medicine is rubbed on the surface of tooth and the enamel of tooth surface is damaged. there was.

The present invention is a tooth improver mainly composed of apatite hydroxide, the possibility of supplementing the problem of the existing toothpaste by using a hydroxide (aydroxyapatite) having the ability to exchange with the normal lattice composition if there are molecules of similar charge and size Focused on, precipitated calcium carbonate and silicon dioxide, which removes plaque, tartar and gives the tooth surface its original luster, and prevents bacteria in the oral cavity from dissolving tooth enamel by corrosive lines and promotes calcium supply By mixing and pasting purified water with drugs such as sodium monofluorophosphate, which strengthens the teeth, the coating on the tooth surface damaged by apatite without impairing enamel on the surface of the tooth gives gloss, whitening effect and tooth decay Characterized by removing To provide a tooth-improving agent with apatite hydroxide powder which has the purpose.

In the present invention for achieving the above object in the tooth improver using the hydroxide apatite powder,

Tooth improving agent consisting of 100 parts by weight of apatite hydroxide powder, 80-100 parts by weight of precipitated calcium carbonate, 5-15 parts by weight of sodium chloride, 120-180 parts by weight of silicon dioxide and 5-10 parts by weight of sodium monofluorophosphate;

200 to 300 parts by weight of purified water based on 100 parts by weight of the apatite hydroxide powder;

Other auxiliary additives; a tooth improver using the apatite hydroxide powder characterized in that the mixture is a problem solving means of the present invention.

The effect of the present invention by the above problem solving means focuses on the possibility of supplementing the problem of the existing toothpaste by utilizing the hydroxide apatite (Hydroxyapatite) having the ability to exchange with the normal lattice composition if there are molecules of similar charge and size As a result, sedimentary calcium carbonate and silicon dioxide, which removes plaque, tartar, and gives the tooth surface its original luster, and prevents bacteria in the oral cavity from dissolving tooth enamel by the corrosive lines and promotes calcium supply By mixing and pasting purified water with a drug such as sodium monofluorophosphate, which makes it stronger, it can be coated on the tooth surface damaged by apatite without giving damage to the enamel of the tooth surface, giving gloss and removing whitening effect and tooth decay bacteria. It is an advantage.

The present invention for achieving the above effect is as follows.

The present invention is a tooth improver using apatite hydroxide powder,

Tooth improving agent consisting of 100 parts by weight of apatite hydroxide powder, 80-100 parts by weight of precipitated calcium carbonate, 5-15 parts by weight of sodium chloride, 120-180 parts by weight of silicon dioxide and 5-10 parts by weight of sodium monofluorophosphate;

200 to 300 parts by weight of purified water based on 100 parts by weight of the apatite hydroxide powder;

Other auxiliary additives; characterized in that the mixture.

Referring to the tooth improving agent used in the present invention in detail.

Apatite hydroxide powder used in the present invention is coated on the damaged tooth surface to give glossiness and serves to remove the whitening effect and tooth decay bacteria. For reference, the apatite hydroxide powder used in the present invention is a size of 200 (≤ 75㎛) ~ 635mesh (≤20㎛) or less, preferably using a size of 325mesh (≤45㎛) or less using a sieving machine desirable. If the size of the powder particles is a particle size smaller than the above-defined range, the effect of polishing the surface of the tooth may be reduced, and if the size of the particles exceed the above-defined range, the enamel of the tooth surface is damaged. There is a concern.

And the precipitated calcium carbonate used in the present invention removes jig, calculus, etc. attached to the teeth and serves to give the original surface gloss. The amount of precipitated calcium carbonate is preferably added to 80 to 100 parts by weight based on 100 parts by weight of apatite hydroxide powder. When the amount of precipitated calcium carbonate is less than 80 parts by weight, the effect of adding precipitated calcium carbonate may be lowered. When the added amount of precipitated calcium carbonate exceeds 100 parts by weight, excessive friction of the added amount of precipitated calcium carbonate may cause severe friction to the enamel surface.

In addition, sodium chloride used in the present invention serves to polish the tartar stuck to the tooth surface with antibacterial properties. The amount of sodium chloride added is preferably 5 to 15 parts by weight based on 100 parts by weight of the apatite hydroxide powder. When the amount of sodium chloride is less than 5 parts by weight, the above effects due to the addition of sodium chloride may be lowered. When the amount added exceeds 15 parts by weight, the above effect does not particularly increase significantly any more.

And silicon dioxide used in the present invention serves to remove the plaque, tartar, and the like attached to the teeth, such as the precipitated calcium carbonate and to give an original luster to the tooth surface. The amount of silicon dioxide added is preferably 120 to 180 parts by weight based on 100 parts by weight of apatite hydroxide powder. When the amount of silicon dioxide is less than 120 parts by weight, the effect of the addition of silicon dioxide may be lowered. When the addition amount of silicon exceeds 180 parts by weight, the friction of the tooth surface is severe due to the excessive amount of silicon dioxide addition may be damaged enamel.

In addition, the sodium monofluorophosphate used in the present invention prevents bacteria in the oral cavity from dissolving tooth enamel by the corrosive lines and serves to strengthen teeth by promoting calcium supply. The amount of sodium monofluorophosphate added is preferably 5 to 10 parts by weight based on 100 parts by weight of apatite hydroxide powder, and when the amount of sodium monofluorophosphate is less than 5 parts by weight, the addition of sodium monofluorophosphate as described above. There is a possibility that the effect of the present invention may be lowered, and when the added amount of sodium monofluorophosphate exceeds 10 parts by weight, the above effects do not increase significantly any more.

Meanwhile, the purified water used in the present invention is added to paste the powder tooth improving agent such as apatite hydroxide powder, precipitated calcium carbonate, etc., and the amount of purified water is 200 to 300 parts by weight based on 100 parts by weight of the apatite hydroxide powder. It is preferable to add. If the amount of purified water is less than 200 parts by weight, the lack of moisture content in the mixture of tooth-improving agents such as apatite hydroxide powder and precipitated calcium carbonate may not form a sufficient paste and cause powder to become entangled and damage the tooth surface. In addition, when the amount of the purified water exceeds 300 parts by weight, there is a fear that the mixture of the paste becomes too thin to be inconvenient to use.

And other auxiliary additives used in the present invention 45 to 55 parts by weight of sodium lauryl sulfate as a foaming agent, 75 to 85 parts by weight of glycerin as a wetting agent, 15 to 25 parts by weight of corn starch as a thickener with respect to 100 parts by weight of apatite hydroxide powder, viscosity 30 to 40 parts by weight of hydrous silicic acid as a regulator, 15 to 25 parts by weight of citric acid as a pH regulator, 45 to 55 parts by weight of peppermint cobalt as a flavoring agent, and 25 to 35 parts by weight of xyitol and sodium saccharin as sweeteners. Detailed description of the auxiliary additives is as follows.

The foaming agent used in the present invention serves to improve the feeling of use and increase the cleaning power by generating bubbles when using the tooth improver, the amount of the foaming agent is to add 45 to 55 parts by weight of the foaming agent to 100 parts by weight of apatite hydroxide powder Preferably, when the addition amount of the foaming agent is less than 45 parts by weight, there is a fear that sufficient bubbles do not occur in the tooth improver paste, and when the addition amount of the foaming agent exceeds 55 parts by weight, the foamability is improved but the tooth improving agent paste is too thin. There is a fear that the use becomes uncomfortable. And in this invention, it is most preferable to use sodium lauryl sulfate as a foaming agent which can be used.

And the humectant used in the present invention serves to maintain the foamability of the foaming agent which is a surfactant. The amount of the wetting agent added is preferably 75 to 85 parts by weight of the wetting agent based on 100 parts by weight of the apatite hydroxide powder, and the bubbleability of the foaming agent is best maintained within the above range. In the present invention, it is most preferable to use glycerin as the humectant that can be used.

In addition, the thickener used in the present invention serves to enhance the viscosity of the tooth improver paste. The addition amount of the thickener is most preferably added 15 to 25 parts by weight of the thickener with respect to 100 parts by weight of apatite hydroxide powder, the optimum viscosity of the tooth improver paste is best maintained within the above range. In the present invention, as the thickener that can be used, it is most preferable to use corn starch.

And the viscosity modifier used in the present invention serves to adjust the viscosity of the tooth improver paste. It is preferable to add 30-40 weight part with respect to the addition amount of a viscosity modifier with respect to 100 weight part of apatite hydroxide powders, and can adjust the appropriate viscosity of a tooth improver paste best within the said range. In the present invention, it is most preferable to use hydrous silicic acid as the viscosity modifier that can be used.

In addition, the pH adjusting agent in the present invention serves to adjust the pH of the tooth improver paste, the pH adjusting agent is preferably added to the pH adjusting agent 15 to 25 parts by weight based on 100 parts by weight of the apatite hydroxide powder. When the addition amount of the pH adjusting agent is within the range defined above, the pH becomes weakly alkaline and the washing power is improved. And it is most preferable to use citric acid as a pH adjuster which can be used by this invention.

In addition, the flavoring agent used in the present invention is for releasing the flavor of the tooth improving agent, the amount of the flavoring agent is preferably added 45 to 55 parts by weight depending on the type of flavoring agent to 100 parts by weight of the apatite hydroxide powder. If the addition amount of the flavoring agent is less than the range defined above, there is a fear that the flavor of the tooth improver does not emanate properly. If the addition amount of the flavoring agent exceeds the range defined above, the fragrance emitted by the tooth improver is too strong and palatability There is a risk of falling. In the present invention, it is most preferable to use a peppermint flavor cobon as the flavoring agent that can be used, but in the present invention, a flavoring agent other than the peppermint flavor cobon defined above may be used according to a manufacturer's need or a consumer's request.

In addition, the sweetener used in the present invention is for flavoring the tooth improver paste, and the amount of the sweetener is preferably added in an amount of 25 to 35 parts by weight, depending on the type of sweetener, based on 100 parts by weight of the apatite hydroxide powder. If the addition amount of the sweetener is less than the above-mentioned range, the taste of the tooth improver paste may not be properly tasted. If the addition amount of the sweetener exceeds the above-defined range, the taste from the tooth improver paste may be too strong. The palatability may fall. In the present invention, the sweeteners that can be used are most preferably xyitol and sodium saccharin. However, in the present invention, a kind other than the sweeteners defined above may be used according to the manufacturer's needs or consumers' needs.

In the present invention, if necessary, a colorant, a preservative, and the like, which can be added to the toothpaste composition, can be used as other auxiliary additives.

Such other coadditives are not a feature of the present invention as coadditives typically added to dentifrice compositions.

Hereinafter, the configuration of the present invention will be described in more detail based on the following examples, but the present invention is not necessarily limited only to the following examples.

1. Preparation of tooth improvers

(Example 1)

100 parts by weight of apatite hydroxide powder, 80 parts by weight of precipitated calcium carbonate, 5 parts by weight of sodium chloride, 120 parts by weight of silicon dioxide and 5 parts by weight of sodium monofluorophosphate, and 200 parts by weight of purified water based on 100 parts by weight of the apatite hydroxide powder. Tooth improver was prepared by mixing with other auxiliary additives.

(Example 2)

100 parts by weight of apatite hydroxide powder, 100 parts by weight of precipitated calcium carbonate, 15 parts by weight of sodium chloride, 180 parts by weight of silicon dioxide and 10 parts by weight of sodium monofluorophosphate and 300 parts by weight of purified water based on 100 parts by weight of the apatite hydroxide powder Tooth improver was prepared by mixing with other auxiliary additives.

The other auxiliary additives added to Examples 1 and 2 were all 45 parts by weight of sodium lauryl sulfate as a foaming agent, 85 parts by weight of glycerin as a wetting agent, 15 parts by weight of corn starch as a thickener, and a viscosity modifier with respect to 100 parts by weight of apatite hydroxide powder. 40 parts by weight of hydrous silicic acid as a pH adjuster, 25 parts by weight of citric acid as a pH adjusting agent, 45 parts by weight of peppermint flavored cobon as a flavoring agent, and 25 parts by weight of xyitol and sodium saccharin as sweetening agents.

2. Tooth Specimen Fabrication

Four molar molars of adult males were cleaned five to six times using distilled water, a brush, and an ultrasonic cleaner. Using the shape and size of the tooth itself will be most effective, but there are many difficulties in the measurement part of various equipment, so the molar was cut and used. 4 enamel parts of 4 teeth are smoothly cut with a diamond cutter (2 pieces, 4 pieces each) and polished up to # 600 ~ 2000 using SiC abrasive paper and aluminum paste (alumina paste) was used to finely polish to 0.2㎛. Then again, the same specimen was attempted using SiC abrasive paper # 2000 to evenly scratch the tooth surface. Uniform force and time were given so that the same scratches could occur as much as possible. Then, it was ultrasonically washed twice over 5 minutes as a method for removing the abrasives stuck to the surface while scratching (scratch).

2 application of fine apatite powder on tooth surface

Three of each of two sets of tooth specimens produced by the method of the present example were selected and stored in the paste prepared according to the method of Examples 1 and 2 for 1 month, 2 months and 3 months, respectively. To prevent exposure to air during tooth storage and evaporation of the slurry, it was deposited in a glass bottle and stored in a vacuum desiccator.

3. Test method

Briefly about the test of the present invention, a clean and healthy adult male teeth to be extracted due to periodontitis was provided and used at the dentist. As a material selected as a tooth surface improving agent, hydroxide apatite powder of 200 (≦ 75 μm) to 635mesh (≦ 20 μm) or less was used. X-ray diffractometer (XRD) was used for the qualitative analysis of the fine apatite hydroxide powder used in the experiment, and the stoichiometry analysis of Ca and P ions was analyzed by energy dispersion X-RAY (EDS). . Quantitative analysis of fine apatite hydroxide powders was determined by inductively coupled plasma release assay (ICP-OES). Scanning electron microscopy (SEM) was used to observe the microstructure of the tooth over time after applying the apatite hydroxide powder on the tooth surface, and the stoichiometric analysis of Ca and P ions was performed through energy dispersion X-RAY (EDS). Analyzed. The phenomenon of hydroxyapatite activation on the tooth surface over time was analyzed by atomic energy microscopy (AFM).

4 Observation of the microstructure of the tooth surface

The microstructural changes were observed by scanning electron microscopy (SEM, HITACHI S-4200, HITACHI, Japan) before and after the tooth surface coated with hydroxide apatite, and the energy dispersion X-RAY (EDS, HORIBA 6853-H, HORIBA, Japan) were used to investigate changes in Ca and P on the improved tooth surface. Atomic energy microscopy (AFM, XE-120, PSIA, KOREA) was used to investigate the amount of change in the apatite hydroxide deactivation on the tooth surface.

5. Test result

end. Analysis of Raw Material of Hydroxyapatite

The result of analyzing the tooth apatite hydroxide powder for improvement in the present embodiment using X-ray diffraction analysis (XRD) is shown in FIG. 1. 2θ, the main peak of the apatite hydroxide powder, was found at 31.8, and the width of the peak was sharp and narrow, and it was confirmed through JCPDS card number 9-432 that all peaks were the apatite hydroxide crystal phase. Inductively coupled plasma emission analysis (ICP-OES) measurement results showed that the weight ratio of CaO and P ₂ O ₅ was 57.0 wt% and 41.4 wt%, respectively, as shown in Table 1 below, and the total amount of other substances was 0.52. It was shown by weight percent. In addition, even in the energy dispersive X-RAY (EDS) results for the quantitative analysis of Ca and P, the molar ratio of Ca / P is 1.67, and it turns out to be high purity apatite hydroxide as shown in the photograph shown in FIG.

(Unit: weight%) Test Analysis Items content SiO ₂ 0.13 Al ₂ O ₃ 0.10 CaO 57.0 MgO 0.02 Fe ₂ O ₃ 0.01 Na ₂ O 0.14 TiO ₂ 0.10 SrO 0.02 P ₂ O ₅ 41.4 Ignition loss 1.05

I. Microstructure of Dental Enamel Surface Stored in Apatite Hydroxide Slurry

The results of observation of the microstructure of the teeth stored for 1 month, 2 months, and 3 months, respectively, of the test piece coated with the tooth improver of Example 1 are shown in the photograph of FIG. 3. A is the result of observing the tooth surface through x50.0K through the test method without storing in the apatite hydroxide slurry. Artificial scratches from # 2000 SiC abrasive paper and the original tooth surface were clean and well cleaned. B, C, D is a result of measuring the tooth surface after a certain time as x50.0K was confirmed that a small change in the scratched surface after two months (Fig. 4, A ). In addition, as a result of the energy dispersive X-RAY (EDS) measurement of agglomerates aggregated on the tooth surface, Ca, P, O components could be confirmed (FIG. 4, B).

The results of the microstructure observation suggest that Ca ²⁺ and PO ₄ ^- ions migrated from the slurry of apatite hydroxide to the tooth surface. This may be due to the movement of capillary pressure and resorption of ions onto the tooth surface.

All. AFM analysis changes the activity of the tooth surface

5 shows the results of activating apatite hydroxide through atomic energy microscopy (AFM) on the tooth surface stored for a predetermined time by applying with the tooth improver of Example 2. FIG. Over time, the applied apatite hydroxide is activated to increase the Ra value (coating thickness), which indicates that the tooth surface is repaired.

As a result of observing the surface microstructure over time after applying apatite hydroxide to the tooth surface in the test of the present Example, the scratched tooth contained in the apatite hydroxide slurry was changed on the surface after 2 months. Three months later, the surface was remarkably restored. This means that the Ca and P ions of the apatite hydroxides, which have the ability to exchange with the normal lattice components, are adsorbed or absorbed on the enamel surface containing 97% of the apatite component, and they bind to the teeth to restore the damaged tooth surface. Judging.

As described above, although described with reference to a preferred embodiment of the present invention, those skilled in the art will be variously modified and modified within the scope of the present invention without departing from the spirit and scope of the present invention described in the claims below. It will be appreciated that it can be changed.

       Figure 1 shows a graph of X-ray diffraction analysis (XRD) data for the hydroxide apatite according to the present invention.

Figure 2 shows the energy dispersive X-RAY (EDS) photograph for the hydroxide apatite according to the present invention.

Figure 3 shows a scanning electron micrograph (SEM) of the tooth coated with hydroxide apatite according to the present invention.

Figure 4 shows the energy dispersive X-RAY (EDS) of the tooth is applied to the hydroxide apatite according to the present invention.

Figure 5 shows an atomic energy micrograph (AFM) of the tooth coated with hydroxide apatite according to the present invention.

Claims (3)

In the tooth improver using apatite hydroxide powder, Tooth improving agent consisting of 100 parts by weight of apatite hydroxide powder, 80-100 parts by weight of precipitated calcium carbonate, 5-15 parts by weight of sodium chloride, 120-180 parts by weight of silicon dioxide and 5-10 parts by weight of sodium monofluorophosphate; 200 to 300 parts by weight of purified water based on 100 parts by weight of the apatite hydroxide powder; Other auxiliary additives; tooth improver using apatite hydroxide powder characterized in that the mixture. The method of claim 1, The other auxiliary additive is 45 to 55 parts by weight of sodium lauryl sulfate as a foaming agent, 75 to 85 parts by weight of glycerin as a wetting agent, 15 to 25 parts by weight of corn starch as a thickener, water-containing silicic acid as a viscosity regulator 30 parts by weight of apatite hydroxide powder -40 parts by weight, 15-25 parts of citric acid as a pH adjusting agent, 45-55 parts by weight of peppermint flavored cobon as a flavoring agent, and 25 to 35 parts by weight of xyitol and sodium saccharin as sweeteners, respectively. The method of claim 1, The apatite hydroxide powder is a special tooth improver, characterized in that the particle size of 200 (≤ 75㎛) ~ 635mesh (≤20㎛).

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