KR20090008938A - Cigarette filter containing ascorbic acid derivatives for reducing of free radicals in mainstream smoke - Google Patents

Abstract

A cigarette filter containing ascorbic acid derivatives is provided, which has the excellent removal effect about the vapor phase free radical and in which negative taste of the cigarette is not generated. A cigarette filter containing ascorbic acid derivatives has sugar ingredient selected from monosaccharide, disaccharide, or polysaccharide as a substituent. The cigarette filter includes ascorbic acid derivative having a substituent selected from the group consisting of the palmitate, stearate, arachidate, laurate, and myristate. Monosaccharide is selected among glucose, fructose, mannose, galactose, and ribose. Disaccharide is selected among sucrose, maltose, and lactose.

Description

Cigarette filter containing ascorbic acid derivatives for reducing of free radicals in mainstream smoke}

The present invention relates to an improved cigarette filter with a scavenging effect of vapor phase free radicals in mainstream smoke occurring during smoking. The present invention uses a filter containing an ascorbic acid derivative such as L-Ascorbic Acid 2-Glucoside and L-Ascorbyl-Palmitate for free radical removal. The present invention also relates to a method for producing an improved tobacco filter having a removal effect on vapor phase free radicals.

Tobacco smoke is known to consist of more than 4,000 compounds, many of which are reported to exist in radical form. Free radicals are commonly referred to as molecular groups with unpaired active electrons, which are characterized by high reactivity and short lifespan. These reduction methods include a method of suppressing the production itself or removing the produced compound by a filter or the like. The free radicals generated at this time are known to be removable by antioxidants. Since the presence of free radicals in the mainstream smoke by Lyons for the first time, it is known that there are about 10 ¹⁶ or more free radicals in common cigarettes.

The reason why such free radicals are attracting attention during mainstream smoke is that carcinogenicity and mutagenesis have been reported by rapid reactivity. It is reported that alkoxy, alkyl radicals, etc. are mainly present in mainstream smoke.

Particulate free radicals in mainstream smoke are known to exist in a stable state because they have lower volatility than vapor free radicals.

Such free radicals are present in a very short time in mainstream tobacco smoke, but because they act as precursors to produce certain substances, the removal of these free radicals can remove certain harmful components.

The free radicals produced in mainstream tobacco smoke can be analyzed mainly by electron rotation resonance spectroscopy (ESR) instruments, especially those with very short decay times, such as vapor phase free radicals, which have a longer shelf life by rotational capture. An adduct is formed to perform the analysis. As the spin trapping solution, DMPO, TEMPO, PBN, or the like may be used depending on the kind of free radicals to be analyzed. In particular, PBN is effective in trapping free radicals in the form of alkoxy or alkyl, which are known to be present mostly in the mainstream smoke.

Cigarette filters for free radical removal in mainstream smoke provided a synthetic filter containing a mixture of polyphenols, vitamin C, and activated carbon extracted from herbal plants jointly studied by the Biophysics Institute and Beijing Cigarette Factory in 1995. Heavy free radicals were reduced by at least about 14%. Activated carbon and hemoglobin-containing filters, invented by Golddene Filters and Filter Development in Greece in 1999, claimed to remove more than 90% of vapor phase free radicals in the mainstream smoke, and proanthoss, invented by Horpag in 2003. Cyanidin-containing filters claimed to have reduced free radicals in mainstream smoke by about 29%. All of these filters are not currently produced as commercial cigarettes by tobacco manufacturers. One of the reasons for this is that they cause negative taste due to the antioxidants added to the filter during smoking. In the case of cigarette filters, the free radical removal effect is drastically reduced with storage time.

Thus, i) a cigarette filter having an excellent removal effect on vapor free radicals in mainstream tobacco smoke; ii) a cigarette filter which removes vapor free radicals in the tobacco filter but does not cause negative taste; and iii) free radical removal during long-term storage. There is a need for a cigarette filter whose effect is not reduced.

In accordance with the requirements as described above, the present invention has an excellent removal effect on free vapor phase radicals, and an object of the present invention is to provide a tobacco filter that does not generate negative taste.

More specifically, the present invention is less likely to enter the human body through the filter during smoking using ascorbic acid derivatives having a larger molecular unit compared to general ascorbic acid, and is negative because it does not give a direct sour taste like ascorbic acid. It is an object of the present invention to provide a tobacco filter that can be used for a long time without causing any taste and having a higher stability than ascorbic acid.

The present invention relates to an improved cigarette filter having a removal effect on vapor free radicals in the mainstream smoke generated during smoking, which can be achieved by adding an ascorbic acid derivative and a mixture of ascorbic acid derivatives and other antioxidants in an effective amount. have.

More specifically, the present invention, as a cigarette filter additive component, has a sugar component selected from monosaccharides, disaccharides or polysaccharides as a substituent; Vapor in mainstream smoke ascorbic acid derivative having any one selected from palmitate, stearate, arachidate, arachidate, laurate, myristate It relates to a cigarette filter, characterized in that it comprises to remove phase free radicals.

The monosaccharide is any one selected from glucose, fructose, mannose, galactose, and ribose, and the disaccharide is sucrose, maltose, and maltose. It is any one selected from lactose, and the polysaccharide is any one selected from amylose and cellulose.

In the present invention, the ascorbic acid derivative is, for example, ascorbic acid 2-glucoside (L-Ascorbic Acid 2-Glucoside) of Formula 1, Ascorbyl palmitate of Formula 2, Ascorbyl stearate of 3, Ascorbyl arachidate of Formula 4, Ascorbyl myristate of Formula 5, Ascorbyl laurate of Formula 6 Ascorbyl laurate).

[Formula 1]

[Formula 2]

[Formula 3]

[Formula 4]

[Formula 5]

[Formula 6]

In general, ascorbic acid is very unstable in heat, light, oxygen, etc., so it is easily exposed to the atmosphere or easily oxidized in aqueous solution, so there is a big problem in stability such as discoloration and odor. When using Ascorbic acid derivatives such as 2-Glucoside and L-Ascorbyl-Palmitate, the molecular weight is high, so it is less likely to enter the human body through the filter during smoking, and because it does not have a sour taste like Ascrobic acid, Does not cause In addition, ascorbic acid derivatives such as L-Ascorbic Acid 2-Glucoside and L-Ascorbyl-Palmitate do not produce oxidation reactions in the air due to the introduced glucoside and palmitate groups. Heavy free radical removal efficiency is characterized by not occurring.

The ascorbic acid 2-glucoside has a structure in which one molecule of glucose is glucoside-linked to a hydroxyl group at the 2-position of vitamin C, which plays a necessary role in redox, and uses glucose-derived enzymes derived from microorganisms to prepare glucose derived from starch. It can be prepared by transferring the hydroxyl group of vitamin c. Ascorbic acid 2-glucoside exhibits the efficacy of the L-ascorbic acid as it is and at the same time has a higher stability than L-ascorbic acid. That is, ascorbic acid 2-glucoside is a form in which the second hydroxyl group of vitamin C is blocked by one molecule of glucose, and thus does not exhibit redox. Therefore, compared with the conventional vitamin C, the stability in the aqueous solution is very high and extremely stable against the oxidative conditions in which heat and metal ions are present.

In the present invention, the ascorbic acid derivative is preferably used in 0.0001 to 2% by weight of the total weight of the filter. If the amount is less than 0.0001% by weight, the effect is insignificant, and if it is more than 2% by weight, it is not economical, which is not preferable. That is, when used in the above range is the most economical and suitable content to remove free radicals.

The cigarette filter according to the present invention may further add an antioxidant substance in addition to the ascorbic acid derivative described above as an additive component. At this time, the ascorbic acid derivative: the mixing ratio of the antioxidant material is preferably used by mixing in 1 to 99: 99 to 1 weight ratio. The reason is that ascorbic acid derivatives are expensive and can be manufactured more economically when a mixture of low-cost antioxidants is used, and it does not impair the elimination effect of free radicals in the mainstream smoke of interest. It can mix and use freely in the range which does not reduce.

The antioxidants include provitamin A, vitamin E, lycopene, lutein, lipoic acid, sesamine, resveratrol, and hyaluronic acid. ), Sulfforaphane (sulforaphane), cinnamon (cinnamon oil), lignin (lignin), flavone (flavone) and rosemary (rosemary) extracts, such as common antioxidants, but is not limited thereto.

In addition, as an antioxidant enhancer to increase the antioxidant effect, one or more selected from citric acid, sodium citrate, calcium ascorbates, magnesium ascorbates, zinc ascorbates, and the like may be further added. Are not limited thereto. In addition, their content can be used in a range that does not interfere with the free radical removal of the antioxidant and ascorbic acid derivatives.

The free radical removing cigarette filter of the present invention should be applied differently as follows according to the solubility of the derivative. That is, the ascorbic acid derivative may be used by spraying in a plasticizer input step or acetate tow manufacturing step in a powder state or in a solution state mixed with a solvent, impregnated in activated carbon, or applied to a surface.

Non-limiting examples of such preferred solvents include, but are not limited to, organic hydrophilic diluents such as lower monohydric alcohols (e.g. C1-C4) and low molecular weight glycols and propylene glycols, polyethylene glycols (e.g. molecular weight 200-600 g / mole), polypropylene glycols. (E.g., molecular weight 425-2025 g / mole), glycerol, butylene glycol, 1,2,4-butanetriol, sorbitol ester, 1,2,6-hexanetriol, ethanol, isopropanol, sorbitol ester, butanediol, Organic hydrophilic diluents such as polyols including ether propanol, ethoxylated ethers, propoxylated ethers and combinations thereof.

Specifically, for example, the water-soluble L-Ascorbic Acid 2-Glucoside may be applied in a plasticizer input process or an initial opening process during filter manufacture, and may be introduced by dissolving in a certain mixture of ethanol and water mixture, and in powder form. Direct introduction is also possible. On the other hand, activated carbon or the like may be impregnated in these solutions at appropriate concentrations, and may be applied evenly to the surface or the pores.

The fat-soluble L-Ascorbyl-Palmitate can be applied to the plasticizer dosing process during filter manufacture, where a separate heating system should be installed in the plasticizer dosing tank to maintain solubility. In the case of L-Ascorbyl-Palmitate, activated carbon may also be introduced by direct introduction or impregnation in powder form.

In the manufacturing method of the cigarette filter according to the present invention, in the manufacturing method of the cigarette filter comprising acetate tow island, plasticizer input and packaging step,

(1) spraying an ascorbic acid derivative or a mixture of an ascorbic acid derivative and an antioxidant with a powder or a solvent in a liquid phase in the acetate tow opening step;

(2) spraying by mixing the plasticizer in a liquid mixture of ascorbic acid derivatives or ascorbic acid derivatives and antioxidants in powder or solvent during the plasticizer input step;

(3) In the packaging step, the ascorbic acid derivative or a mixture of ascorbic acid derivatives and an antioxidant mixture in a powder or a solvent is applied to the surface of the activated carbon particles or zeolite particles as a porous adsorbent, or prepared by dipping. can do.

The improved cigarette filter containing ascorbic acid derivatives such as L-Ascorbic Acid 2-Glucoside and L-Ascorbyl-Palmitate according to the present invention can not only achieve the effect of removing vapor phase free radicals in tobacco smoke, It is also expected to be industrially useful as it has no negative impact.

Hereinafter, the present invention will be described by way of example for the detailed description of the present invention, but the present invention is not limited to the following examples.

Example 1

Table 1 below is a mixture of ascorbic acid derivatives used in the manufacture of L-Ascorbic Acid 2-Glucoside (AA-2G, Hayashibara biochemical laboratory Inc.) and a mixed solution of water, ethanol and triacetin (Triacetin, TA). The ratio is shown. As shown in Table 1 below, 30 L of a mixed solution was prepared according to the capacity of the plasticizer tank used for preparing the filter, and AA-2G was mixed and used in addition to the amount of the plasticizer treatment solution in the amount shown in Table 1 below. It was. The amount of AA-2G introduced into the filter was calculated in accordance with 2000 Production Per Minute (RPM).

TABLE 1

A double composite filter was prepared by combining a filter containing a predetermined amount of activated carbon (2 mg / mm) with an acetate acetate filter prepared by spraying the mixed solution prepared in the plasticizer spraying step. In this case, the length of the acetate mono part containing the mixed solution of the double composite filter is 12 mm, the activated carbon part including the activated carbon is 15 mm, and the pressure drop of the entire cigarette filter is fixed to 320 mmH ₂ O to form the same system as a commercial cigarette filter. It was.

Table 2 below shows the results of analyzing the actual L-Ascorbic Acid 2-Glucoside (AA-2G) content and the amount of triacetin (Triacetin, TA) in one double composite filter manufactured as described above.

TABLE 2

A cigarette prototype was prepared by applying the same sheath to the manufactured cigarette filter. At this time, the weight of each herb in the cigarette was fixed to 640mg, using this to evaluate the effect of free radical reduction in the mainstream smoke. At this time, the cigarette was selected using the same herbaceous weight, filter pressure drop, and the sample used in the experiment was harmonized by the ISO conditions, the smoking experiment was performed.

In addition, the Borgwaldt RM 20 / CS automatic smoking device was used for free radical analysis in mainstream smoke, and a collector containing 5 mL PBN (0.01 M in Hexane) collection solution under a 10 ° C. cold trap was used to capture vapor phase free radicals. 4 pieces were used.

ESR analysis was performed after mixing four solutions exactly 15 minutes after the start of smoking. ESR analysis conditions were modulation amplitude of 6.3 G, modulation frequency of 100 KHz, and the ESR samples used for analysis contained 0.7 mL in quartz tubes. Manganese markers were used to correct the errors between the analyzes.

In addition, TEMPO (2,2,6,6-tetramethyl-1-piperinyloxyl) reagent was used to calibrate the instrument for quantification, and the obtained ESR spectra were evaluated for the number of spins in solution through double integration. The free radical removal rate in mainstream smoke was made into the reference sample (no addition) 100, and the comparative analysis was performed.

(In the above formula, Ns represents the free radical spin number of the mainstream smoke passing through the antioxidant-containing cigarette filter, and Nc represents the free radical spin number of the mainstream smoke through the non-added cigarette filter.)

The removal efficiency of the L-Ascorbic Acid 2-Glucoside (AA-2G) -containing cigarette filter is shown in FIG. 1 by calculating the number of free radical spins in the mainstream smoke obtained as described above per TPM and then adding the value of the unadded cigarette to 100. It was.

As shown in Figure 1, the removal efficiency of the vapor phase free radicals by the cigarette filter containing L-Ascorbic Acid 2-Glucoside (AA-2G) is 13 ~ 24% of the value of the non-added cigarette filter according to the AA-2G concentration Indicated.

Example 2

Table 3 below shows the mixing ratio of the mixed solution of ascorbic acid derivative and triacetin (Triacetin, TA) used in the manufacture of L-Ascorbyl-Palmitate (AAP, Merck & Co., Inc.)-Containing cigarette filter. As shown in Table 3, 30 L of a mixed solution was prepared according to the capacity of the plasticizer tank used for preparing the filter, and AAP was added to and mixed with 30 L of the plasticizer treatment solution in the amount shown in Table 3 below. The amount of AAP introduced into the filter was calculated in accordance with 2000 production headquarters per minute (RPM).

TABLE 3

A double composite filter was prepared in the same manner as in Example 1 using the acetate mono filter thus prepared.

Table 4 below shows the results of analyzing the actual L-Ascorbyl-Palmitate (AAP) content and the amount of plasticizer TA (Triacetin) in one double composite filter manufactured as described above.

TABLE 4

The manufactured cigarette filter was manufactured as a cigarette under the same conditions as in Example 1, and the free radical reduction effect in the mainstream smoke was evaluated using the same. At this time, the cigarette was selected using the same citrus weight and filter pressure drop, the sample used in the experiment was harmonized according to the ISO conditions, the smoking experiment was carried out using the formula (1) free radical reduction effect in the mainstream smoke Was evaluated, and the results calculated by the removal efficiency per TPM as shown in Example 1 are shown in FIG.

As shown in FIG. 2, the removal efficiency of vapor phase free radicals per TPM by the L-Ascorbyl-Palmitate (AA-P) -containing cigarette filter was 10-30% higher than that of the unadded cigarette filter.

Example 3

The L-Ascorbic Acid 2-Glucoside (AA-2G) and L-Ascorbyl palmitate (AAP) -added cigarette filter was stored for one month under the three conditions shown in Table 5 below to have 13% moisture again. After the adjustment, the effect of free radical removal in mainstream smoke was evaluated in the same manner as in Example 1.

TABLE 5

The results are shown in FIG. 3, and as shown in FIG. 3, it was confirmed that the free radical removal efficiency of the cigarette filter containing the ascorbic acid derivative was not significantly changed depending on the storage conditions. In particular, L-Ascorbic acid 2-Glucoside (AA-2G) -containing filter showed a very small change in free radaki removal efficiency. From the above results, it was confirmed that the free radical removal efficiency did not decrease even when stored for a long time in the case of the cigarette filter containing the ascorbic acid derivative used in the present invention.

Example 4

6 items (Smoking) by 25 highly trained sensory personnel on cigarettes and additive-free cigarettes made with cigarette filters containing L-Ascorbic Acid 2-Glucoside (AA-2G) and L-Ascorbyl-Palmitate (AAP) QDA analysis was performed after smoking sensory evaluation was performed on all tastes, smoking taste, irritability, taste intensity, total tobacco taste, and aftertaste) by a 15-point scale.

In this case, the evaluation method was generally based on the items that affect the preferences most commonly when smokers select cigarettes.

-Premature taste before smoking: Cigarettes before smoking should not be inherent in the original scent, degrading the value of the product. The stronger the feeling, the more 15 points.

-Smoking odors: Smoking should not be inherent in the taste or aroma of tobacco. It is a factor that lowers the value of the product.

-Irritation: Smell of thorns, tingling, and mesmerizing sensation in the mouth, throat, nose, etc. lasts for more than 1 second, and gradually disappears after a sudden intense feeling.

-Taste intensity: Intensive intensity felt in the mouth, nose, back of the neck and upper thorax within 1 second when drinking or exhaling smoke. The intensity is very short and 15 points direction.

-Tobacco flavor: Character of smoke body, richness, richness, harmony, etc. It is the intensity of tobacco taste felt as a whole rather than individual characteristics.

-Clean aftertaste: It means that after smoking, it feels like powder is covered in the mouth, bites or sticks, and there is no cream or oil on it.

As a result, as shown in FIG. 4 and FIG. 5, the sensory evaluation between the L-Ascorbic Acid 2-Glucoside (AA-2G) -containing cigarette filter and the non-added filter resulted in no significant difference between the samples.

In addition, the cigarette filter containing L-Ascorbyl-Palmitate (AAP) showed a better result in the range of significant difference in the off-item items before smoking, and the other items did not show a significant difference. From the above results, it was confirmed that the L-Ascorbic Acid 2-Glucoside (AA-2G) and L-Ascorbyl-Palmitate (AAP) -containing cigarette filters used in the present invention did not cause negative taste in smokers during smoking.

Example 5

Cigarette filter containing 0.86 mg of L-Ascorbic Acid 2-Glucoside (AA-2G) per filter (AA2G-3 of Example 1) and 0.20 mg of L-Ascorbyl-Palmitate (AAP) per filter Cytotoxicity to the cigarettes prepared by (AAP-2 of Example 2) and the unadded filter (control) is shown in FIG. 6.

At this time, the cytotoxicity was evaluated by the cytotoxicity of TPM samples using Neutral Red Uptake, the cell line was used CHO-K1, the cytotoxicity is expressed by EC50 (ug-TPM / mL), a concentration that kills cells 50% It was.

As shown in Figure 6, cytotoxicity did not show a significant difference between L-Ascorbic Acid 2-Glucoside (AA-2G), Ascorbyl-Palmitate (AAP) -containing filter and no added cigarette.

Meanwhile, mutagenicity for the same cigarette filter was 37 ± 7 for the spontaneous return group (negative control) and 1786 ± 6 for the positive control, and is shown in FIG. 7 as a result obtained by performing three repeated experiments.

As shown in FIG. 7, L-Ascorbic Acid 2-Glucoside (AA-2G) and Ascorbyl-Palmitate (AA-P) -containing filters did not show any significant difference between unadded cigarettes and mutagenicity. Ascorbic acid derivatives added to the cigarette filter was confirmed that the transition does not cause mutagenicity and cytotoxicity during smoking.

The functional tobacco filter according to the present invention is not only able to achieve the effect of removing the free phase of the vapor phase in the tobacco smoke, but also has no negative effect on taste and is industrially useful.

Figure 1 shows the increase in free radical removal efficiency in the mainstream smoke of the cigarette attached to the L-Ascorbic acid 2-Glucoside (AA-2G) addition filter.

Figure 2 shows the vapor phase free radical removal efficiency of the mainstream smoke of the cigarette attached to the Ascorbyl Palmitate (AAP) addition filter.

Figure 3 shows the vapor phase free radical removal efficiency of the mainstream smoke of the cigarette attached to the filter containing the ascorbic acid derivative according to long-term storage conditions.

4 is a result of sensory evaluation QDA analysis of taste between L-Ascorbic acid 2-Glucoside (AA-2G) added sample and non-added sample.

5 is a result of sensory evaluation QDA analysis of taste between L-Ascorbyl Palmitate (AAP) addition sample and no addition sample.

6 is a cytotoxicity evaluation results of Ascorbic acid derivatives and untreated samples.

7 shows mutagenicity evaluation results of ascorbic acid derivatives and untreated samples.

Claims (15)

As a cigarette filter additive, it has a sugar component selected from monosaccharides, disaccharides or polysaccharides as a substituent, palmitate, stearate, arachidate, laurate, myristate Ascorbic acid derivative having any one selected from Cigarette filter, characterized in that for removing the vapor free radicals in the mainstream smoke. The method of claim 1, The monosaccharide is any one selected from glucose, fructose, mannose, galactose, and ribose, and the disaccharide is sucrose, maltose, and maltose. Any one selected from lactose (lactose), The polysaccharide is a cigarette filter, characterized in that any one selected from amylose, cellulose. The method of claim 1, The ascorbic acid derivatives are ascorbic acid 2-glucoside (L-Ascorbic Acid 2-Glucoside), ascorbyl palmitate, ascorbyl stearate, ascorbyl arachidate (Ascorbyl arachidate), an ascorbyl laurate, and an ascorbyl myristate. The method of claim 3, wherein The ascorbic acid derivative is a cigarette filter, characterized in that used in 0.0001 ~ 2% by weight of the total weight of the filter. The method of claim 4, wherein The cigarette filter is a cigarette filter, characterized in that the addition of antioxidants in addition to the ascorbic acid derivative is used as an additional component. The method of claim 5, Mixing ratio of the ascorbic acid derivatives: antioxidants is a cigarette filter, characterized in that used by mixing in a 1 to 99: 99 to 1 weight ratio. The method of claim 6, The antioxidants include provitamin A, vitamin E, lycopene, lutein, lipoic acid, sesamine, resveratrol, and hyaluronic acid. ), A sulforaphane (sulforaphane), cinnamon (cinnamon oil), lignin (lignin), flavone (flavone) and rosemary (rosemary), a cigarette filter, characterized in that using any one or more selected. The method of claim 7, wherein In addition to the ascorbic acid derivatives and antioxidants, any one or more antioxidants selected from citric acid, sodium citrate, calcium ascorbates, magnesium ascorbates, and zinc ascorbates are further added. Cigarette filter, characterized in that. The method of claim 1, The ascorbic acid derivative is dissolved in a powder or a solvent to spray in a plasticizer input step or acetate tow manufacturing step, or impregnated in activated carbon or applied to the surface of the cigarette filter, characterized in that used. In the manufacturing method of the cigarette filter comprising the acetate tow opening, plasticizer input and packaging step, The method of manufacturing a cigarette filter, characterized in that during the acetate tow opening step is prepared by spraying a liquid mixture of ascorbic acid derivatives or ascorbic acid derivatives and antioxidants in powder or solvent. The method of claim 10, Method of producing a cigarette filter, characterized in that during the plasticizer input step ascorbic acid (ascorbic acid) derivative or a mixture of ascorbic acid derivatives and antioxidants in powder or solvent mixed with a plasticizer in the liquid phase and prepared by spraying. The method of claim 10, Preparation of a cigarette filter characterized in that the ascorbic acid derivatives or ascorbic acid derivatives and a mixture of the antioxidants in a powder or solvent is applied to the surface of the porous adsorbent or immersed during the packaging step Way. The method according to any one of claims 10 to 12, The ascorbic acid derivative is ascorbic acid 2-glucoside (L-Ascorbic Acid 2-Glucoside), ascorbyl palmitate, ascorbyl stearate, ascorbyl stearate, ascorbyl A method for producing a cigarette filter, characterized in that at least one selected from ascorbyl arachidate, ascorbyl laurate, ascorbyl myristate. The method of claim 13, The antioxidants include provitamin A, vitamin E, lycopene, lutein, lipoic acid, sesamine, resveratrol, and hyaluronic acid. ), Sulforaphane (sulforaphane), cinnamon (cinnamon oil), lignin (lignin), flavone (flavone) and rosemary (rosemary) extract of any one or more selected from the method of manufacturing a cigarette filter. The method of claim 14, The ascorbic acid derivative: The mixing ratio of the antioxidant material is a method of manufacturing a cigarette filter, characterized in that used by mixing in a 1 to 99: 99 to 1 weight ratio.

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