KR20080063528A - Dentifrice composition free of abrasive material - Google Patents

Abstract

A dentifrice composition comprising, (a) a hydrophilic clay material, (b) a phytic acid compound, (c) an effective amount of an oral care active, and (d) a polar solvent carrier; wherein the composition is substantially free of abrasive material.

Description

Abrasive-free toothpaste composition {DENTIFRICE COMPOSITION FREE OF ABRASIVE MATERIAL}

The present invention is directed to toothpaste compositions that are substantially abrasive and can still maintain the cleaning effect of conventional creamy toothpastes.

Toothpaste compositions, such as creamy toothpastes, are routinely used by consumers as part of their oral care hygiene regimens. It is well known that oral care products can provide consumers with both therapeutic and cosmetic hygiene effects. Therapeutic effects include, but are not limited to, caries prevention, gingivitis prevention and hypersensitivity control. Cosmetic effects include, but are not limited to, control of plaque and tartar formation, removal and prevention of tooth stains, whitening teeth, removal of odors, and aesthetics of feeling in the mouth, such as feeling of freshness or slippery sensation no.

The use of abrasives such as silica has long been regarded as important in delivering the therapeutic and cosmetic effects of the aforementioned toothpaste compositions. The abrasive provides physical wear between the toothbrush and the teeth for cleaning plaques, stains and tartar, while also forming the rheology and structure of the toothpaste to maintain the thermal stability of the entire formulation.

At the same time, however, the use of abrasives may have certain negative effects on the overall formulation. For example, the cost of silica itself is expensive. In addition, silica adsorbs components in typical toothpaste compositions, such as active agents, flavoring agents, and blowing agents, whereby the concentration of these components must be adjusted according to the expected loss by silica. In addition, certain active agents, such as cetylpyridinium chloride, are inferior in compatibility with silica and therefore cannot be included in toothpaste compositions despite their known effectiveness. In another aspect, it is a general consumer's idea that the abrasive may erode enamel if the teeth are brushed too strongly.

Based on the foregoing, there is a need for a toothpaste composition that is free of abrasives while still delivering the effects of conventional toothpaste compositions. Specifically, there is a need for a non-abrasive toothpaste composition having thermal stability and capable of delivering the same cleaning effect as commercially available abrasive-containing compositions.

Summary of the Invention

The present invention

(a) an affinity clay material;

(b) phytic acid compounds;

(c) an effective amount of an oral care active; And

(d) contains a polar solvent carrier,

A toothpaste composition is substantially abrasive free.

The invention also relates to a method for cleaning teeth free of abrasives.

These and other features, aspects, and advantages of the invention will be apparent to those skilled in the art upon reading the disclosure of the invention in conjunction with the appended claims.

The following is a list of definitions for terms used herein.

"Including" means that other steps and components may be added that do not affect the end result. This term includes the terms "consisting of" and "consisting essentially of".

All percentages are by weight of the total composition unless specifically stated otherwise.

All cited references are hereby incorporated by reference in their entirety. No citation of any document is to be taken as an adjudication of any usefulness as prior art to the claimed invention.

All ratios are by weight unless specifically stated otherwise.

The invention is explained in detail in the product and method aspects thereof as follows.

a) hydrophilic clay material

The composition of the present invention swells or thickens in the presence of a polar solvent and contains a hydrophilic clay material that acts as a binder in the toothpaste composition. The hydrophilic clay material can be any known that is safe and aesthetically acceptable for oral care applications. Hydrophilic clay materials are present in various product forms, including brushing liquid, gel and cream toothpaste, having a viscosity of about 1 mPas to about 450,000 Pas as measured by a Brookfield viscometer with a TE spindle. Rheology suitable for the toothpaste composition of the invention is provided. In one highly preferred embodiment, the toothpaste composition of the present invention is a gel or cream toothpaste of suitable body and viscosity, wherein the viscosity is from about 10,000 Pas to about 450,000 Pas, preferably from about 10,000 Pas to about 250,000 Pas . As discussed later, additional binders may be added to provide such suitable rheology.

Surprisingly, it has been found that hydrophilic clay materials provide the suitable stability described above at relatively low levels and at relatively low cost, without the presence of abrasives in the composition.

The hydrophilic clay material is preferably contained from about 0.01% to about 10%, preferably from about 1% to about 5% by weight of the total composition.

Hydrophilic clay materials useful in the present invention include natural and synthetic layered silicate minerals, fumed silica, thickened precipitated silica and mixtures thereof. The layered silicate minerals may be naturally occurring or synthesized such that magnesium substitutes a certain fraction of the minerals. Fumed silicas are those that provide very little or no abrasive function, having a particle size of less than about 5 μm, typically from about 1 nm to about 1 μm. Thickened precipitated silicas have a DOA value of at least about 150 ml / 100 g, preferably at least about 250 ml / 100 g and a particle size of about 1 μm to about 50 μm. Thickened precipitated silica can be distinguished from abrasive silica material because of its high oil absorption capacity, as defined by DOA values. Such abilities provide thickening properties.

Commercially available hydrophilic clay materials useful in the present invention are synthesized layered magnesium silicate, average particle size, available from Rockwood Additives Limited and Southern Clay Company under the trade name LAPONITE series. Is about 12 nm and is a fumed silica available from Cabot and Degussa Corporation, under the tradename AEROSOL series and CAB-O-SIL, under the tradename ZEODENT. ) Jay by 165. M. Amorphous precipitated silica available from JM Huber Company and from Grace Davision under SYLOX 15, and precipitated silica available from Rhodia under the tradename TIXOSIL. do.

b) phytic acid compound

The composition of the present invention contains a phytic acid compound in an amount that provides effective cleaning power to the teeth. Phytic acid, also known as inositol hexaphosphate or myo-inositol hexaphosphate, is a natural vegetable biodegradable chelating agent in liquid form, whose chelating ability is comparable to that of EDTA. Botanical sources from which phytic acid compounds can be found include cereal grains, legumes, nuts, oilseed seeds, pollen, spores, and organic soils.

The phytic acid compound of the present invention may be phytic acid itself and / or salts acceptable for oral use, which salts include, but are not limited to, alkali metal salts and alkaline earth metal salts. Useful phytic acid salts include sodium phytate, potassium phytate, magnesium phytate, calcium phytate, tin phytate, zinc phytate, copper phytate, iron phytate, and mixtures thereof.

Surprisingly, phytic acid compounds have been found to provide excellent cleaning effects in the abrasive-free compositions of the present invention without consumer perceptible stains and are compatible with the polar solvent carriers of the present invention and a wide variety of oral care active ingredients. Without being bound by theory, it is believed that the phytic acid compound provides a unique superior detergency by the flow between the teeth due to its liquid form. Such flows are believed to provide cleaning power in a different way than solid abrasives. It is also believed that the phytic acid compound provides a positive effect on the protective effect of tooth enamel from acid dissolution, and a tartar prevention effect.

Commercially available phytic acid compounds useful in the present invention include phytic acid solution, sodium phytic acid, magnesium phytic acid, calcium phytic acid and tin phytic acid, which include Sichuan Chengdu Yason, Shikishima Starch Manufacture Available from Shikishima Starch Manufacturing Company and Nibbio.

c) oral care actives

Compositions of the present invention contain an oral care active agent that delivers the intended therapeutic oral care effect. Oral care active agents useful in the present invention include tartar inhibitors, tin ion sources, fluoride ion sources, whitening agents, antimicrobial agents, plaque inhibitors, anti-inflammatory agents, nutrients, antioxidants, antiviral agents, analgesics and anesthetics, zinc-containing layered materials, and their Mixtures.

c-1) tartar inhibitors

Oral care agents useful in the present invention include tartar preventive agents, which may be present in one embodiment in an amount from about 0.05% to about 50% by weight of the oral care composition, in another embodiment from about 0.05% to About 25%. Tartar preventers include polyphosphates (including pyrophosphates) and salts thereof; Polyamino propane sulfonic acid (AMPS) and salts thereof; Polyolefin sulfonates and salts thereof; Polyvinyl phosphate and its salts; Polyolefin phosphates and salts thereof; Diphosphonates and salts thereof; Phosphonoalkane carboxylic acid and salts thereof; Polyphosphonates and salts thereof; Polyvinyl phosphonates and salts thereof; Polyolefin phosphonates and salts thereof; Polypeptides; And mixtures thereof. In one embodiment, the salt is an alkali metal salt. Polyphosphates are generally used as fully or partially neutralized water soluble alkali metal salts such as potassium, sodium, ammonium salts and mixtures thereof. Inorganic polyphosphate salts include alkali metal (eg sodium) tripolyphosphate, tetrapolyphosphate, dialkyl metal (eg disodium) diacid, trialkyl metal (eg trisodium) monoacid, hydrogen phosphate Potassium, sodium hydrogen phosphate and alkali metal (eg sodium) hexametaphosphate and mixtures thereof. Polyphosphates larger than tetrapolyphosphate generally appear as amorphous glassy materials. In one embodiment, the polyphosphate is prepared from FMC Corporation and is made of Sodaphos (n, 6), Hexaphos (n ≒ 13), and Glass H (n ≒ 21, hexameta Sodium phosphate) and those mixtures known commercially. Pyrophosphate salts useful in the present invention include alkali metal pyrophosphates, di-, tri-, and mono-potassium or sodium pyrophosphates, dialkali metal pyrophosphate salts, tetraalkali metal pyrophosphate salts, and mixtures thereof It includes. In one embodiment, the pyrophosphate salts include trisodium pyrophosphate, disodium dihydrogen pyrophosphate (Na ₂ H ₂ P ₂ O ₇ ), dipotassium pyrophosphate, tetrasodium pyrophosphate (Na ₄ P). ₂ O ₇ ), tetrapotassium pyrophosphate (K ₄ P ₂ O ₇ ), and mixtures thereof. Polyolefin sulfonates include those in which the olefin group contains two or more carbon atoms and salts thereof. Polyolefin phosphonates include those in which the olefin group contains two or more carbon atoms. Polyvinylphosphonates include polyvinylphosphonic acid. Diphosphonates and salts thereof include azocycloalkane-2,2-diphosphonic acid and salts thereof, azocycloalkane-2,2-diphosphonic acid and ions of salts thereof, azacyclohexane-2,2-diphosphonic acid , Azacyclopentane-2,2-diphosphonic acid, N-methyl-azacyclopentane-2,3-diphosphonic acid, EHDP (ethane-1-hydroxy-1,1, -diphosphonic acid), AHP ( Azacycloheptan-2,2-diphosphonic acid), ethane-1-amino-1,1-diphosphonate, dichloromethane-diphosphonate, and the like. Phosphonoalkane carboxylic acids or their alkali metal salts include PPTA (phosphonopropane tricarboxylic acid) and PBTA (phosphonobutane-1,2,4-tricarboxylic acid) as acid or alkali metal salts, respectively. Polyolefin phosphates include those in which the olefin group contains two or more carbon atoms. Other useful materials include synthetics including maleic anhydride or copolymers of maleic acid and methyl vinyl ether (eg Gantrez) and polyacrylates, as disclosed, for example, in US Pat. No. 4,627,977. Anionic polymers, for example polyamino propane sulfonic acid (AMPS), zinc citrate trihydrate, polyphosphates (eg tripolyphosphate; hexametaphosphate), diphosphonates (eg EHDP; AHP ), Polypeptides (eg, polyaspartic acid and polyglutamic acid), and mixtures thereof. In addition, the oral care compositions are disclosed in polymer carriers, such as those described in US Pat. No. 6,682,722 and US Pat. No. 6,589,512, and US Patent Application Nos. 10 / 424,640 and US Patent Application No. 10 / 430,617. It may contain the thing.

c-2) tin ion source

Oral care agents useful in the present invention include a tin ion source. Tin ions may be provided from tin fluoride and / or other tin salts. Tin fluoride has been found to help improve the effects of gingivitis, plaque, sensitivity, and bad breath. Tin ions provided in an oral composition will provide efficacy to a subject using the composition. While efficacy may include effects other than gingivitis reduction, efficacy is defined as a marked amount of reduced in situ plaque metabolism. Formulations that provide such efficacy typically include tin levels in the range of about 3,000 ppm to about 15,000 ppm tin ions in the total composition, provided by tin fluoride and / or other tin salts. Tin less than about 3,000 ppm does not have sufficient efficacy of tin. Tin ions are present in an amount of about 4,000 ppm to about 12,000 ppm, in one embodiment about 5,000 ppm to about 10,000 ppm. Other tin salts include organic carboxylic acid tin such as tin acetate, tin gluconate, tin oxalate, malonic acid tin, tin citrate, tin ethylene glycoside, tin formate, tin sulfate, lactic acid tin, tin tin, and the like. . Other tin ion sources include tin halides such as tin chloride, tin bromide, tin iodide and tin chloride dihydrate. In one embodiment, the tin ion source is tin fluoride, and in another embodiment, tin chloride dihydrate. The combined tin salt may be present in an amount from about 0.001% to about 11% by weight of the composition. The tin salt may be present in an amount of about 0.01% to about 7% in one embodiment, about 0.1% to about 5% in another embodiment, and about 1.5% to about 3% in other embodiments. have.

c-3) fluoride ion source

Oral care agents useful in the present invention include a source of fluoride ions for providing a caries prevention effect. Among these materials are inorganic fluoride salts such as soluble alkali metal fluoride salts such as sodium fluoride, potassium fluoride, sodium monofluorophosphate and sodium hexafluorosilicate. Alkali metal fluorides are preferred, for example sodium fluoride, sodium monofluorophosphate, sodium hexafluorosilicate and mixtures thereof.

The amount of fluorine providing salt is generally present in a composition for oral use at a concentration of about 0.0 to about 3.0 weight percent. Although any suitable minimum amount of such salts may be used, it is preferred to use sufficient fluoride salts to release from about 50 ppm to about 3500 ppm, preferably from about 300 ppm to 2,000 ppm of fluoride ions.

c-4) whitening agent

Oral care agents useful in the present invention include whitening agents. Suitable active agents for whitening are alkali and alkaline earth metal peroxides, metal chlorites, perborates-including monohydrates and tetrahydrates-, superphosphates, percarbonates, peroxy acids, alkali metals and persulfates, for example ammonium, potassium, Sodium and lithium persulfate, and combinations thereof. Suitable peroxide compounds include hydrogen peroxide, urea peroxide, calcium peroxide, carbamide peroxide, magnesium peroxide, zinc peroxide, strontium peroxide and mixtures thereof. In one embodiment, the peroxide compound is carbamide peroxide. Suitable metal chlorites include calcium chlorite, barium chlorite, magnesium chlorite, lithium chlorite, sodium chlorite and potassium chlorite. Further whitening active agents may be hypochlorite and chlorine dioxide. In one embodiment the chlorite is sodium chlorite. In another embodiment, the percarbonate is sodium percarbonate. In one embodiment, the persulfate is oxone. The level of the material depends on the available oxygen or chlorine, respectively, which can discolor the pigmentation. In one embodiment, the whitening agent is from about 0.01% to about 40% by weight of the composition, in other embodiments from about 0.1% to about 20%, in other embodiments from about 0.5% to about 10%, in other embodiments about It may be present at a level of 4% to about 7%.

c-5) antimicrobial agents

Oral care agents useful in the present invention include other antimicrobial agents. Such agents may include, but are not limited to: 5-chloro-2- (2,4-dichlorophenoxy) -phenol, commonly referred to as triclosan; 8-hydroxyquinoline and its salts; Copper II compounds including, but not limited to, copper (II) chloride, copper (II) sulfate, copper (II) acetate, copper fluoride (II), and copper (II) hydroxide; Phthalic acid and salts thereof, including, but not limited to, those disclosed in US Pat. No. 4,994,262, including magnesium monopotassium phthalate; Chlorhexidine; Alexidine; Hextidine; Sanguinarin; Benzalkonium chloride; Salicylicanilide; Domiphene bromide; Cetylpyridinium chloride (CPC); Tetradecylpyridinium chloride (TPC); N-tetradecyl-4-ethylpyridinium chloride (TDEPC); Octenidine; iodine; Sulfonamides; Bisbaiguanides; Phenolic substances; Delmofinol, octapinol and other piperidino derivatives; Niacin preparations; Zinc and tin ionic agents such as zinc oxide, zinc lactate and zinc citrate; Nystatin; Grapefruit extract; Apple extract; Thyme oil; Thymol; Antibiotics such as augmentin, amoxicillin, tetracycline, doxycycline, minocycline, metronidazole, neomycin, kanamycin, cetylpyridinium chloride and clindamycin; Analogs and salts thereof; Essential oils including thymol, geraniol, carbachol, citral, hinokithiol, eucalyptol, catechol (particularly 4-allyl catechol) and mixtures thereof; Methyl salicylate; Hydrogen peroxide; Metal salts of chlorite; And mixtures of all of the above. The antimicrobial component may be present from about 0.001% to about 20% by weight of the composition.

c-6) plaque inhibitors

Oral care agents useful in the present invention include other plaque inhibitors, for example dimethyl isosorbide, copper salts, strontium salts, magnesium salts or dimethicone copolyols. Dimethicone copolyols are selected from C12 to C20 alkyl dimethicone copolyols and mixtures thereof. In one embodiment, the dimethicone copolyol is a cetyl dimethicone copolyol sold under the trade name Abil EM90. In one embodiment, the dimethicone copolyol is at a level of from about 0.001% to about 25%, in other embodiments from about 0.01% to about 5%, in other embodiments from about 0.1% to about 1.5% by weight of the composition May exist.

c-7) anti-inflammatory

Oral care agents useful in the present invention include anti-inflammatory agents. Such formulations may include, but are not limited to, nonsteroidal anti-inflammatory agents such as oxycam, salicylate, propionic acid, acetic acid and phenamate. Such NSAIDs include ketorolac, flurbiprofen, ibuprofen, naproxen, indomethacin, diclofenac, etodorac, indomethacin, sullindac, tolmethine, ketoprofen, phenofene, pyroxicamp , Nabumethone, aspirin, diflunisal, meclofenamate, mefenamic acid, oxyphenbutazone, phenylbutazone and acetaminophen. The use of NSAIDs such as ketorolac is claimed in US Pat. No. 5,626,838. Disclosed in this patent is a method of preventing and / or treating primary and recurrent squamous cell carcinoma of the oral or oropharyngeal by topically administering an effective amount of NSAID to the oral or oropharyngeal. Suitable steroidal anti-inflammatory agents include corticosteroids such as flucinolone, and hydrocortisone.

c-8) nutrients

Oral care agents useful in the present invention include nutrients that improve the condition of the oral cavity. Nutritional supplements include minerals, vitamins, oral nutritional supplements, enteric nutritional supplements, and mixtures thereof. Useful minerals include calcium, phosphorus, zinc, manganese, potassium and mixtures thereof. Vitamins can be contained with minerals or used independently. Suitable vitamins include vitamins C and D, thiamine, riboflavin, calcium pantothenate, niacin, folic acid, nicotinamide, pyridoxine, cyanocobalamine, para-aminobenzoic acid, bioflavonoids and mixtures thereof. Oral nutritional supplements include amino acids, lipotropics, fish oils, and mixtures thereof. Amino acids include, but are not limited to, L-tryptophan, L-lysine, methionine, threonine, senile carnitine or L-carnitine and mixtures thereof. Reportropic includes, but is not limited to, choline, inositol, betaine, linoleic acid, linolenic acid and mixtures thereof. Fish oils contain large amounts of omega-3 (N-3) polyunsaturated fatty acids, eicosapentaenoic acid and docosahexaenoic acid. Enteric nutritional supplements include, but are not limited to, protein products, glucose polymers, corn oil, safflower oil, medium chain triglycerides. Minerals, vitamins, oral nutritional supplements and enteric nutritional supplements are described in Drug Facts and Comparisons (loose leaf drug information service), Wolters Kluer Company, St. Louis, Mo., © 1997, pps. 3-17 and 54-57.

c-9) antioxidants

Oral care agents useful in the present invention include antioxidants. Antioxidants are disclosed in text such as Cadenas and Packer, The Handbook of Antioxidants, © 1996 by Marcel Dekker, Inc. Antioxidants useful in the present invention include, but are not limited to, vitamin E, ascorbic acid, uric acid, carotenoids, vitamin A, flavonoids and polyphenols, herbal antioxidants, melatonin, aminoindole, lipoic acid, and mixtures thereof.

c-10) antiviral agents

Oral care agents useful in the present invention include antiviral active agents used to treat viral infections. Such antiviral actives include phosphono formic acid; Shiosin derivatives; Purine analogs such as adenosine, guanosine and inosine analogs; Pyrimidine bases such as cytidine and thymidine; Amantadine; Rimantadine HCl; Ribavirin; Zanamivir; Oseltamivir phosphate; Trifluidine; Heterocyclic dyes; Acyclovir; Famciclovir; Germinated cyclovir, sipofovir; Gancyclovir; Levimisol; Idoxiuridine; Lipophilic β-ketones; And thiosemicarbazone, but are not limited thereto. These antiviral active agents are described in Drug Facts and Comparisons (loose-leaf drug information service), Wolters Kluwer Company, St. Louis, Mo., © 2001, pp. 1400-1423 (b) and Kirk-Othmer, Encyclopedia of Chemical Technology, Fourth Edition, Volume 3, Wiley-Interscience Publishers (1992), pp. 576-607.

c-11) analgesics and anesthetics

Oral care agents useful in the present invention include pain prevention or desensitizing agents. Analgesics are agents that act on the central nerve to relieve pain and raise pain thresholds without disturbing consciousness or other sensory modalities. Such agents may include, but are not limited to: strontium chloride; Potassium nitrate; Sodium fluoride; Sodium nitrate; Acetanilide; Phenacetin; Acetopane; Thiorphan; Spiradoline; aspirin; codeine; Thebaine; Leborphenol; Hydromorphone; Oxymorphone; Phenazosin; Fentanyl; Buprenorphine; Butapanol; Nalbuphine; Pentazosin; Natural herbs such as gall nut; Asarum; Cubebin; Galanga; Skcutellaria; Liangmianzhen; And Baizhi, but are not limited thereto. Anesthetics or topical analgesics may also be present, such as acetaminophen, sodium salicylate, trolamine salicylate, lidocaine and benzocaine. Such analgesic active agents are described in Kirk-Othmer, Encyclopedia of Chemical Technology, Fourth Edition, Volume 2, Wiley-Interscience Publishers (1992), pp. 729-737, for example.

c-12) zinc-containing layered material

Useful as oral care actives in the present invention are zinc containing layered materials, which have an effective antimicrobial and gingivitis protective effect due to high zinc instability. The zinc containing layered materials particularly useful in the present invention have a relative zinc instability of greater than about 25%, an average particle size of less than about 20 microns, and a large surface area. As will be discussed later, in one preferred embodiment, the zinc containing layered material of the present invention is incorporated into a composition containing an anionic surfactant.

Zinc instability is a measure of the chemical availability of zinc ions. Soluble zinc salts that do not complex with other species in solution, by definition, have a relative zinc instability of 100%. In general, the use of partially soluble forms of zinc salts and / or incorporation of potential complexing agents into the matrix lowers the zinc instability to substantially below the defined 100% maximum. Unstable zinc is maintained by the selection of an effective zinc containing layered material or in situ formation of an effective zinc containing layered material by known methods.

Zinc instability is assessed by the combination of diluted zinc containing solutions or dispersions with the metallochromic dye xylenol orange (XO) and the measurement of the degree of color change under specified conditions. The degree of color formation is proportional to the level of unstable zinc. The developed procedure has been optimized for aqueous surfactant formulations but can be modified for other physical product forms.

A spectrophotometer is used to quantify the color change at 572 nm, which is the optimal color change wavelength for XO. Except for the exclusion of potentially unstable forms of zinc, the spectrophotometer is set to zero absorbance at 572 nm, using a product control close to the test product in composition. The control and test product are then treated in the same manner as follows. 50 μl of product sample is dispensed into the bottle, degassed 95 ml of distilled water is added and stirred. 5 ml of 23 mg / ml xylenol orange stock solution at pH 5.0 is pipetted into the bottle of the sample and this is considered time zero. The pH is then adjusted to 5.50 ± 0.01 using dilute HCl or NaOH. After 10.0 minutes, a portion of the sample is filtered (0.45 μ) and absorbance is measured at 572 nm. The measured absorbance is then compared to the individually measured control to determine relative zinc instability (TO 100% of 0). A control of 100% instability is prepared in the matrix using a soluble zinc material (eg zinc sulfate) similar to the test product but incorporated at an equivalent level based on zinc. The absorbance of the control at 100% instability is measured as described above for the test material. The relative zinc instability is preferably greater than about 15%, more preferably greater than about 20%, and even more preferably greater than about 25%.

Using this method, the following examples show materials with high intrinsic instability (basic zinc carbonate) in anionic surfactant systems compared to those with low intrinsic instability (ZnO).

In the zinc-containing layered structure, crystal growth occurs mainly in two dimensions. It is common to describe the layer structure not only in that all atoms are contained within a well defined layer, but also as the presence of ions or molecules between the layers, called gallery ions (AF Wells "Structural Inorganic"). Chemistry "Clarendon Press, 1975]. A zinc-containing layered material (ZLM) may have zinc contained in the layers and / or be components of gallery ions.

Many ZLMs occur naturally as minerals. Typical examples include hydrozincite (zinc carbonate hydroxide), basic zinc carbonate, aurichalcite (zinc copper carbonate hydroxide), rosasite (copper zinc carbonate hydroxide) and Many related minerals containing zinc are included. Natural ZLMs may also appear, where anionic layer species, for example clay-based minerals (eg, phyllosilicates), comprise zinc gallery ions that are ion exchanged. All of these natural materials can also be obtained synthetically, formed in situ in the composition or formed during the manufacturing process.

A common class of ZLMs, which are often synthetic, but not always, are layered double hydroxides, represented generally by the formula [M2 + 1-xM3 + x (OH) 2] x + Am-x / mHnO, partially or All of these divalent ions (M2 +) are represented as zinc ions (Crepaldi, EL, Pava, PC, Tronto, J, Valim, JB J. Colloid Interfac. Sci. 2002, 248, 429-42).

Another class of ZLMs called hydroxy double salts can be prepared (Morioka, H., Tagaya, H., Karasu, M, Kadokawa, J, Chiba, K Inorg. Chem. 1999, 38, 4211- 6]). The hydroxy double salt can be represented by the general formula [M2 + 1-xM2 + 1 + x (OH) 3 (1-y)] + An- (1 = 3y) /n.nH2O, where two metals If the ions can be different and they are the same or appear as zinc, the formula is simplified to [Zn1 + x (OH) 2] 2x + 2x A-nH2O. This latter formula represents common materials such as zinc hydroxychloride and zinc hydroxynitrate (when x = 0.4). They also relate to hydrozincite in which divalent anions have replaced monovalent anions. In addition, these materials may be formed in situ in the composition or may be formed during or during the manufacturing process.

These classes of ZLMs represent relatively common examples of general categories and are not intended to be limited to a broader range of materials that meet this definition.

Available sources of basic zinc carbonate include Zinc Carbonate Basic (Cater Chemicals: Bensenville, Ill.), Zinc Carbonate (Shepherd Chemicals: Norwood, Ohio, USA Material: zinc carbonate (CPS Union) Corp.): New York, New York, USA; Zinc carbonate (Elementis Pigments: Durham, UK) and Zinc carbonate AC (Bruggemann Chemical: Newtown Square, Pennsylvania, USA).

Basic zinc carbonate, which may also be commonly referred to as "zinc carbonate" or "zinc carbonate basic" or "zinc hydroxy carbonate", is a synthetic variant of a material similar to naturally occurring hydrozincite. The idealized stoichiometric properties are represented by Zn 5 (OH) 6 (CO 3) 2, but the actual stoichiometric ratios may vary slightly and other impurities may be incorporated into the crystal lattice.

d) polar solvents carrier

The composition of the present invention contains a polar solvent carrier to deliver the essential ingredients and to provide a suitable rheology for the hydrophilic clay material. The polar solvent also serves as a solvent for the incorporation of water soluble oral care actives and other ingredients.

The polar solvent is contained in about 1% to about 95%, preferably from about 30% to about 70% by weight of the total composition.

Polar solvents useful in the present invention include water, polyhydric alcohols such as glycerin, 1,3-butylene glycol, propylene glycol, hexylene glycol, propane diol, ethylene glycol, diethylene glycol, dipropylene glycol, diglycerine, Sorbitol and other sugars in liquid form at ambient temperature. Water soluble alkoxylated nonionic polymers such as polyethylene glycol are also useful in the present invention.

In one preferred embodiment, the compositions of the present invention may contain relatively high levels of water to provide a cost effective product. In such preferred embodiments, water is contained in about 30% to about 95%, more preferably from about 50% to about 70% of the total composition.

Commercially available polar solvents include glycerin available from Asahi Denka; Propylene glycol available from Inolex under the tradename LEXOL PG-865 / 855, and 1,2-propylene glycol USP available from BASF; 1,3-butylene glycol available from Daisei Kagaku Kogyo; Dipropylene glycol available from BASF under the same brand name; Diglycerin, available from Solvay GmbH under the tradename DIGLYCEROL, polyethylene glycol available from Doe Chemical Company under the trade name PEG 300, and callista (Ryuzo) Chemical Industries, Limited Sorbitol 70% solution available from Khalista (Liuzhou) Chemical Industries, Ltd.

Abrasive material

The composition of the present invention is virtually free of abrasives. That is, the composition of the present invention is free of intentionally contained abrasives. Surprisingly, it has been found that the compositions of the present invention can deliver the effects of conventional dentifrice compositions, including those typically due to the use of abrasives, such as cleaning, stain removal, plaque removal, tartar removal, and the like. In addition, the absence of abrasives leads to the inclusion of certain active agents, such as cetylpyridinium chloride, which otherwise would be inferior in compatibility with abrasives such as silica and cannot be included in toothpaste compositions. In addition, due to the absence of abrasives, various aesthetic properties of toothpaste products may be pursued. For example, a composition of transparent appearance may be made.

Abrasives substantially absent from the compositions of the present invention are defined as materials having a DOA value of about 150 ml / 100 g or less, preferably about 100 ml / 100 g or less and a particle size of about 5 μm to about 50 μm. The abrasive of the present invention can be distinguished from materials useful as binders in the present invention.

Abrasives absent from the compositions of the present invention include inorganic minerals such as silica gel and precipitates; Alumina; Particulate condensation products of hydrated alumina, calcium carbonate, titanium dioxide, talc, calcium dioxide, and resinous abrasives such as urea and formaldehyde.

Additional binder material

The composition of the present invention may further contain additional binder material which further forms a rheology to the composition, or which provides a certain feeling in the mouth when used. When contained, the additional binder material is selected from those compatible with the hydrophilic clay material, such that the total amount of hydrophilic clay material and additional binder material is from about 0.1% to about 10% of the total composition, and from about 10,000 Pa to about It is contained to provide a viscosity of 450,000 Pa, preferably about 10,000 Pa to about 250,000 Pa.

In the present invention, the modified cellulose polymer is a binder material useful for making a continuous structure for the composition. Modified cellulose polymers useful in the present invention include sodium carboxymethyl cellulose, polyvinylpyrrolidone, hydroxyethylpropylcellulose, hydroxybutyl methyl cellulose, hydroxypropy methyl cellulose, and hydroxyethyl cellulose. Particularly useful commercially available materials include sodium carboxymethyl cellulose from Hercules under the trade names BLANOSE series, OPTICEL 100, and AQUALON series; Hydroxyethylpropylcellulose from Hercules under the KLUCEL series, from Yixing City No. 8 CHEMICAL PLANT under the trade name TF-E25 and from Hercules under the trade name BENECEL. Hydroxypropyl methyl cellulose.

In the present invention, the carboxyvinyl anionic polymer is a binder material useful for making three-dimensional structures in combination with the hydrophilic clay materials disclosed herein above. Carboxyvinyl anionic polymers useful in the present invention are those of the CARBOPOL series (or CARBOMER), for example Carbopol 956, 934, 940, 941, 1342, ETD 2020, ULTREZ Syntalene, available from Carbopol 934, 940, 974 P, and 3V Company from BF Goodrich, 10 "from Noveon Inc. (SYNTHALEN) Contains K.

In the present invention, the natural rubber derived anionic polymer is a binder material useful for effectively adding viscosity. Natural rubber derived anionic polymers useful in the present invention include carrageenan, xanthan rubber, gellan rubber and locust bean rubber. Particularly useful commercially available materials are xanthan rubbers available from CP Kelco under the tradename KELDENT series and available from Rhodia under the RHODICARE series; Gellan rubbers available from CPI Kelco under the brand name KELCOGEL series; And locust bean rubbers available from FMC BioPolymer under the brand name GELLOID LB series.

In the present invention, starch and carrageenan are also useful as binder materials. Carrageenan is sold under the trademark Viscori series and GELCARIN series from FMC biopolymers, under the brand name MEYPRO-SOL series from Meyhall AG, and under the brand name Genuvisco. ), The Genu series and the Genutine series are available from CPI Kelco.

Additional ingredients

The composition of the present invention may also contain other additional ingredients, which may be selected by one of ordinary skill in the art depending on the desired properties of the final product, which makes the composition cosmetically or aesthetically more acceptable or additional to them. It is suitable for providing benefits in use. Such additional ingredients are generally used individually at levels of up to about 5% by weight of the composition.

When applied to the oral cavity, a surfactant may be incorporated into the components of the present invention as a component to assist in the complete dispersion of the toothpaste throughout the mouth and to improve cosmetic acceptability and foaming properties. Surfactants that may be contained in the compositions of the present invention include anionic, nonionic or amphoteric compounds, with anionic compounds being preferred.

Suitable examples of anionic surfactants include higher alkyl sulfates such as potassium or sodium lauryl sulfate, which is preferred, higher fatty acid monoglyceride monosulfates, for example monosulfated monoglycerides of hydrogenated coconut oil fatty acids. Salts, alkyl sulfonates, for example sodium dodecyl benzene sulfonate, higher fatty sulfoacetates, higher fatty acid esters of 1,2 dihydroxypropane sulfonate.

Examples of water soluble nonionic surfactants are condensation products of ethylene oxide with various hydrogen containing compounds that are reactive with ethylene oxide and have long hydrophobic chains (e.g., aliphatic chains of about 12 to 20 carbon atoms)-condensation The product comprises a hydrophilic polyoxyethylene moiety-a condensation product of poly (ethylene oxide) with fatty acids, fatty alcohols, fatty amides and other fatty moieties, and poly (ethylene oxide), propylene oxide and Condensation products with polypropylene oxide, for example Pluronic materials, for example Pluronic F127.

The surfactant may be present in the composition of the present invention at a concentration of about 0.5 to about 10.0 weight percent, preferably about 1 to about 2 weight percent.

Other ingredients that may be incorporated into the dentifrice compositions of the present invention include pigments, dyes, flavors and sweetening materials. For example, a striped product is obtained according to the present invention, wherein a complementary colorant is incorporated into each of the components used in the practice of the present invention, the colorant being pharmacologically and physiologically when used in the proposed amounts. Academicly nontoxic. Colorants used in the present invention include both pigments and dyes.

Pigments useful in the present invention are non-toxic, water-insoluble inorganic pigments such as titanium dioxide and chromium oxide green, ultramarine blue and pink, and on ferric oxide as well as alumina. Water insoluble dye lakes prepared by increasing calcium or aluminum salts of FD & C dyes, such as FD & C Green 1 Lake, FD & C Blue 2 Lake, FD & C R & D 30 Lake, FD & C Yellow 5 and FD & C Yellow 15 Lake do. The concentration of the dye in the composition of the present invention is about 3% by weight or less. The pigments of the invention are distinguished from abrasives, which are virtually absent from the compositions of the invention, because the pigments of the invention range in particle size from 100 to about 1000 microns, preferably from about 250 to about 500 microns. When present, pigments are contained in the compositions of the present invention at about 0.5% to about 3% by weight.

Any suitable flavoring or sweetening material may also be incorporated into the components of the present invention. Examples of suitable flavoring ingredients include flavoring oils such as spearmint oil, peppermint oil, oil of wintergreen, oil of sassafras, cloves oil, sage oil, eucalyptus oil, marjoram oil, cinnamon, lemon, and Orange and methyl salicylate. Suitable sweeteners include sucrose, lactose, maltose, sorbitol, xylitol, sodium cyclate, perillartin and sodium saccharin. Suitably, the flavoring and sweetening agents may be contained together in 0.01% to 5% or more of the formulation.

Enzyme inhibitors, plant extracts, natural herbal extracts, and the like may also be contained.

The following examples further illustrate and show preferred embodiments within the scope of the invention. The examples are presented for purposes of illustration only and are not intended to limit the invention, as many variations thereof are possible within the scope and scope of the invention.

The following toothpaste compositions are formed with the following ingredients using the manufacturing methods described herein.

Definition of ingredients

* 1 Sodium fluoride: NaF, available from Jinan Chemical Industry Co. Ltd.

* 2 Sorbitol (70% solution): Sorbitol 70% solution, available from Callista (Ryuzo) Chemicals Industries Limited

* 3 Glycerin: Glycerin, available from Asahi Denka

* 4 Polyethylene glycol: PEG-300, available from Dough Chemical Company

* 5 Sodium Lauryl Sulfate (28% solution): SLSS, available from Rhodia Specialty Chemical Wuxi Co. Ltd.

* 6 Sodium Carboxymethyl Cellulose: CMC, available from Zhangjiagang City Sanhui Chemical Industry Co., Ltd.

* 7 Carbopol: Carbomer 956, available from Noveon, Inc.

* 8 Xanthan Gum: Available from Keldent, CPI Kelco Inc.

* 9 Carrageenan: Zelcarin TP911, available from FMC Corporation food ingredients division

* 10 synthesized layered magnesium silicate 0.2% fluoride: available from Laponite DF, Lockwood Additives Limited

* 11 Synthetic layered magnesium silicate: available from Laponite D, Lockwood Additives Limited

* 12 Amorphous precipitated silica: zeodet 165, j. M. Available from Hoover Company

* 13 fumed silica: available from aerosol, cabot, and degussa corporation

* 14 Titanium dioxide coated mica: available from Rona

* 15 sodium hydroxide solution (50%): 50% NaOH, available from Guangzhou Chemical Company

* 16 tetrasodium pyrophosphate: tetrasodium pyrophosphate (anhydrous), available from Liayungang Duoling Fine Chemical Co. Ltd.

* 17 Sodium monophosphate monohydrate: available from Jiangsu Chengxing Phosphate Chemical Co. Ltd., MSP, Jiangsu Chengxing Phosphate Chemical Co. Ltd.

* 18 Trisodium Phosphate: TSP, available from Jiangsu Jiangyin Phosph Chemicals

* 19 Sodium Pyrate 20% Solution: available from Sichuan Chengdu Yason

* 20 Sodium Saccharin: available from Suzhou Fine Chemical

* 21 Tin fluoride: SnF2, available from Hashimoto

* 22 Triclosan: available from Ciba-Geigy Chemicals Ltd.

* 23 Cetylpyridinium Chloride: available from Cambrex company

* 24 Zinc carbonate: available from Brugemann Chemical

Manufacturing method

The toothpaste compositions of Examples 1-10 can be prepared by any method known to those skilled in the art, and are prepared as follows suitably.

First, the hydrophilic clay material (component numbers 10-13) is dissolved in a portion of water in a vessel at room temperature and mixed until homogeneous using a propeller mixer. In a separate main mixing pot, sorbitol solution (component number 2), glycerin (component number 3), polyethylene glycol (component number 4), sodium hydroxide solution (component number 15), dyes and pigments ( Component No. 14) and the remaining portion of water were mixed together at a rotational speed of 2.6 kW / s (25 rpm) to 3.7 kW / s (35 rpm) using an agitator at elevated temperature.

All remaining ingredients except flavor and surfactant (component number 5) are added to the main mixing pot. The port is sealed closed, a vacuum is formed at approximately 13.3 kPa (100 mmHg) and the homogenizer is turned on at a rotational speed of 251.3 kPa / s (2400 rpm) to 366.5 kPa / s (3500 rpm). The obtained mixture is further degassed.

The mixture prepared in the first step is added to it. The obtained mixture is mixed and degassed. Finally, the flavor and surfactant (component number 5) were added, the pot was sealed closed again and turned on at a rotational speed of 2251.3 dl / s (400 rpm) to 366.5 dl / s (3500 rpm) for final homogenization Mix with a homogenizer and degas.

The product obtained is pumped out of the container and delivered to a primary packaging such as laminate tube.

The compositions of the present invention in the examples have a number of effects suitable for toothpaste products. All compositions provide lower wear to the tooth surface compared to creamy toothpastes including abrasives and are safer for tooth enameling. All compositions provide a soft feel in the mouth, easier dispersibility, and improved access in the interdental area compared to creamy toothpastes including abrasives. All compositions allow consumers to perceive the fragrance better when compared to creamy toothpastes comprising an abrasive and the same level of flavoring agent. In addition, all compositions can be prepared at economical cost. The compositions of Examples 1-5 provide caries prevention, plaque prevention, whitening, and tartar prevention effects. The compositions of Examples 6-7 provide caries prevention, plaque prevention, whitening, tartar prevention and gingivitis prevention effects. The compositions of Examples 8-9 provide caries prevention, plaque prevention, whitening, tartar prevention and antimicrobial effects. The composition of Example 10 provides caries prevention, plaque prevention and tartar prevention effects.

The dimensions and values disclosed herein are not to be understood as being strictly limited to the exact numerical values listed. Instead, unless stated otherwise each such dimension is intended to mean both the listed value and the functionally equivalent range around that value. For example, a dimension disclosed as "40 mm" is intended to mean "about 40 mm."

All documents cited in the Detailed Description of the Invention are hereby incorporated by reference herein, and citation of any document should not be construed as an admission of this document as prior art to the present invention. If any meaning or definition of a term in this document is in conflict with any meaning or definition of term in the document incorporated by reference, the meaning or definition assigned to the term in this document is governed.

While specific embodiments of the invention have been illustrated and described, it will be apparent to those skilled in the art that various other changes and modifications can be made without departing from the spirit and scope of the invention. Accordingly, all such changes and modifications that fall within the scope of the invention are intended to be included in the appended claims.

Claims (13)

(a) hydrophilic clay material; (b) phytic acid compounds; (c) an effective amount of an oral care active; And (d) contains a polar solvent carrier, Toothpaste composition substantially free of abrasive. The method of claim 1, (a) about 0.1% to about 10% hydrophilic clay material; And (b) a dentifrice composition containing from about 0.01% to about 20% phytic acid compound. The method of claim 1, Toothpaste composition wherein the hydrophilic clay material is selected from the group consisting of natural and synthetic layered silicate minerals, fumed silica, thickened precipitated silica and mixtures thereof. The method of claim 3, A dentifrice composition wherein the hydrophilic clay material is synthetic layered magnesium silicate. The method of claim 1, A dentifrice composition further comprising a further binder material selected from the group consisting of modified cellulose polymers, carboxyvinyl polymers, anionic polymers derived from natural rubber, and mixtures thereof. The method of claim 1, Oral care actives from the group consisting of tartar preventers, tin ion sources, fluoride ion sources, whitening agents, antimicrobial agents, plaque inhibitors, anti-inflammatory agents, nutrients, antioxidants, antiviral agents, analgesics and anesthetics, zinc-containing layered substances and mixtures thereof Toothpaste composition selected. The method of claim 6, A dentifrice composition wherein the oral care active is selected from the group consisting of fluoride ion sources, tin ion sources, pyrophosphate salts, polyphosphate salts, hydrogen peroxide, triclosan and mixtures thereof. The method of claim 6, A dentifrice composition wherein the oral care active is an anti-cavity active selected from the group consisting of cetylpyridinium chloride, tin ion source, and mixtures thereof. The method of claim 6, A dentifrice composition wherein the oral care active is a zinc containing layered material having a relative zinc lability of greater than about 25%. The method of claim 9, The zinc-containing layered material comprises basic zinc carbonate, zinc carbonate hydroxide, zinc copper carbonate hydroxide, aurichalcite, copper zinc carbonate hydroxide, rosasite, and foliar silicates containing zinc ions ( phyllosilicate), layered double hydroxides, hydroxyl double salts, and mixtures thereof. The method of claim 9, The toothpaste composition whose zinc containing layered material is basic zinc carbonate. The method of claim 1, Toothpaste composition, wherein the polar solvent carrier comprises from about 30% to about 95% water by weight of the total composition. A method of cleaning teeth without abrasive, comprising the steps of brushing the teeth with the toothpaste composition of claim 1.