KR20080024506A - Aqueous composition solubilized with fat-soluble substances and water-solubilization method - Google Patents

Abstract

An aqueous composition comprising water-solubilized fat-soluble substances is provided to improve convenience and simplicity of solubilization process for fat-soluble substances including coenzyme Q10, ceramide and vitamin E acetate by using sucrose fatty acid ester, so that stably solubilized fat-soluble substances are applicable to various drugs, food, drink, cosmetics and fodder. An aqueous composition for solubilizing fat-soluble substances in water comprises: fat-soluble substances including food oil, lipid, coenzyme Q, fat-soluble vitamins and having average particle diameter of 10-800 nm; fat-soluble flavors; hydrocarbons or their derivatives; sucrose fatty acid ester represented by the formula(1) in which R is -(CH2)nH and n is an integer from 5 to 21; and water. A method for solubilizing fat-soluble substances in water comprises the steps of: mixing sucrose fatty acid ester represented by the formula(1) with fat-soluble substances; and adding water into the mixture to prepare emulsion. Further, the food oil is selected from a group consisting of lard, beef tallow, chicken oil, whale oil, liver oil, cotton seed oil, safflower oil, rice oil, corn oil, rape seed oil, palm oil, beefsteak plant oil, Perilla ocimoides oil, cacao butter, peanut oil, coconut oil, evening primrose oil, Borage oil, milk fat, butter and triglyceride.

Description

Aqueous Composition solubilized with Fat-Soluble Substances and Water-Solubilization method

The present invention is an aqueous solution composition and a water-soluble method in which a fat-soluble substance is suitably applicable to various medicines, foods, beverages, cosmetics, and feed fields by simply and conveniently receiving a sucrose fatty acid ester in a stable state. It is about.

Coenzyme Q ₁₀ produces an energy source in vivo and inhibits free radicals in cells, which is why it has antioxidant properties and nutritional treatments such as vitamins and medical treatments such as cardiovascular disease, periodontal disease, hypertension, rheumatism and Parkinson's disease. It may be taken orally as a supplement (US Pat. No. 6,461,593). By the way, coenzyme Q ₁₀ is soluble in water and hardly soluble in water, so it is used only for oral and transdermal use, and bioavailability applied through drugs to humans is insignificant (Japanese Patent No. 2003-03389, 2003-0505523). ).

Coenzyme Q ₁₀ is possible to be a need for a micelle is moved onto the receiving To be absorbed into the sheet because it is a fat-soluble molecules, and the coenzyme Q ₁₀ is coenzyme Q ₁₀ is completely dissolved in order to facilitate a mixture of the colloidal particulate form. Therefore been many attempts to improve the bioavailability of coenzyme Q ₁₀ is in progress through the development of an emulsifier, a surfactant, and the oil medium for solubilization of coenzyme Q _10.

Recently, several reports have been published on the exacerbation of diseases caused by increased oxidative pressure in the blood. Typical examples include atherosclerosis and complications of diabetes.

The disease can be caused by the degeneration of lipids due to various oxidative pressures in the blood and can be exacerbated by it. In order to suppress the effect of such oxidative compression, it is effective to enhance the antioxidant activity by administering an antioxidant.

Vitamin E is a very effective sample of fat-soluble antioxidants that inhibit lipid peroxidation and is widely used to prevent disease. Report (Bowry et al ., 1993, J. American Chemical Society , 115, 6029-6044, reports that vitamin E must be co-reduced with reducible coenzyme Q ₁₀ to facilitate its antioxidant activity.

These facts indicate that coenzyme Q ₁₀ plays an important role as a fat-soluble antioxidant.

Since the coenzymes Q ₁₀ are active in themselves, they can effectively increase the antioxidant activity in the blood by sending the reducing coenzyme Q ₁₀ into the blood sufficiently in solution. As a result, enhanced antioxidant activity in the blood prevents vascular lesions during ischemia-reperfusion, prevents restenosis during atherosclerosis, and cerebral infarction. Greatly useful in preventing vascular lesions that accompany it, in preventing atherosclerosis, in preventing complications of diabetes, and in many other diseases exacerbated by active oxygen species. Is considered. Furthermore, it is expected that there will be a number of advantages if the coenzyme Q ₁₀ can be delivered in vivo to patients with severe or brain diseases that cannot be orally administered, that is, in aqueous solution.

Coenzyme Q ₁₀ is in the form of both the reduced and oxidized there, much research on solubilization method of the coenzyme (ubidecarenone or ubiquinone) oxide have been conducted so far (JP-A-05-186340, 1 - No. 07-69874 , 2000-510841, Kishi et al ., 1999, BioFactors , 10, 131-138).

Since because of the coenzyme Q ₁₀ oxidized in the blood there is no reductase can be converted to the reduced form of coenzyme Q ₁₀ this must be present in a reduced form to the anti-oxidant role in the blood, of the oxidized coenzyme Q ₁₀ Solubilization studies have little value.

Since reduced coenzyme Q ₁₀ is very sensitive to oxidizing agent and temperature, it is very important to easily dissolve while maintaining the reduced form and to allow the solution to stabilize at temperatures within the compatibilization range.

Meanwhile, a method for dissolving coenzyme Q ₁₀ with a cyclodextrins complex has been proposed (Japanese Patent Nos. 59-047202, 56-109590, 60-089442, US Patent Publication No. 2003/0012774) European Patent No. 1174109 (2002), German Patent No. 10139851 and the like have various problems in stability and commerciality.

Several other techniques for solubilizing coenzyme Q ₁₀ have been reported, but are difficult to apply to medicines, foods, beverages, cosmetics and feeds.

For example, according to a report of Japanese Patent Laid-Open No. 60-199814, polyethylene glycol and castor oil are added and coenzyme Q ₁₀ is emulsified with a high pressure homogenizer.

In Japanese Patent Laid-Open No. 63-150221, coenzyme Q ₁₀ is dissolved in adipic acid or soybean oil, followed by polyoxyalkylene base, polyglycerol fatty acid ester, and twin base. base) to emulsify coenzyme Q ₁₀ .

In EP 494651 and US Pat. No. 5,298,246, coenzyme Q ₁₀ is dissolved in oil and emulsified coenzyme Q ₁₀ using a fat globule membrane in mammals milk.

In addition, Japanese Patent No. 2000-212066 discloses a method of emulsifying coenzyme Q ₁₀ in polyglycerol fatty acid ester, glycerol-phosphoric lipid and polyalcohol and emulsifying it with a high pressure homogenizer. Is proposing.

These methods use very complex dissolution systems to accommodate coenzyme Q ₁₀ and use special equipment, which not only increases the complexity and cost of the process, but also does not achieve the same effect.

The present inventors have found that the new substance is sucrose other fat-soluble substance results of applying a fatty acid ester, had a stable aqueous solution containing the coenzyme Q ₁₀ can be produced, wherein the coenzyme Q ₁₀ as well as to screen receives a coenzyme Q ₁₀ Also confirmed that the solubilization is possible to complete the present invention.

Accordingly, it is an object of the present invention to provide an aqueous solution composition in which a fat-soluble substance is solubilized in a stable state with a constituent system of sucrose fatty acid ester and a method for receiving the same.

In order to achieve the above object, the present invention is solubilized fat-soluble material,

Sucrose fatty acid ester represented by Formula 1 below;

Fat-soluble substances; And

Containing water

An aqueous solution composition is provided:

[Formula 1]

(In Formula 1, R is-(CH ₂ ) _n H, wherein 5≤n≤21)

In addition, the present invention is to receive a fat-soluble material,

Mixing the sucrose fatty acid ester of Formula 1 with a fat soluble material; And

Preparing an emulsion by adding water to the obtained mixture

It provides a method of receiving a fat-soluble material comprising a.

The solubilization method according to the present invention is a simple and convenient sucrose fatty acid ester composition system that overcomes the limitations of the existing method for the preparation of aqueous solutions containing fat-soluble substances including coenzyme Q ₁₀ , ceramide, vitamin E acetate and the like. .

Hereinafter, the present invention will be described in more detail.

The aqueous solution composition in which the fat-soluble substance according to the present invention is accommodated is

Sucrose fatty acid ester represented by Formula 1 below;

Fat-soluble substances; And

Contains water.

(In Formula 1, R is-(CH ₂ ) _n H, wherein 5≤n≤21)

Sucrose fatty acid ester of the formula (1) is used alone or a mixture of two or more fatty acid esters n is 5 to 21.

The shorter the carbon chain length of the fatty acid of the sucrose monoester used for the solubilization of these fat-soluble substances, the shorter the time the solution is emulsified and the lower the temperature of the emulsified solution.

Preferably, the fatty acid of the sucrose mono ester is caprylyl (C8) with n = 8, capryl (C10) with n = 10, lauryl (C12) with n = 12, myristyl (C14) with n = 14 , n = 16 palmityl (C16), n = 18 oleyl (C18), stearyl (C18), n = 20 behenyl (C20).

In the embodiment of the present invention, sucrose mono laurate, sucrose mono palmitate, sucrose mono stearate, sucrose mono oleate were used alone or in combination of two or more.

The fat soluble substance which can be solvated by such sucrose mono ester fatty acid is not particularly limited in the present invention, and all fat soluble substances known in the art are possible.

The fat-soluble substance may be one selected from the group consisting of food oils, lipids, coenzyme Q, fat-soluble vitamins, fat-soluble flavors, hydrocarbons or derivatives thereof.

For example, the food oil includes oil synthesized from animals, plants and microorganisms and oils synthesized, and includes lard, beef tallow, chicken oil, and whale oil. oil, liver oil, cotton seed oil, safflower oil, rice oil, corn oil, rape seed oil, palm oil, seesaw oil (beefsteak plant oil), perilla ocimoides oil, cacao butter, peanut oil, coconut oil, evening primrose oil, borage oil, Milk fat, butter and synthetic triglyceride oils.

The lipids include sphingolipids (ceramide, sphingomyelin, glycosphingolipid), octacosanol, phosphatidylserine, phosphatidylcholine, phosphatidylethanolamine (phosphatidyl ethanolamine), and phosphatidyl ethanolamine. phosphatidylinositol, phytosterol, lycopene, beta-carotene, lutein and SAIB (sucrose acetic acid / isobutyric acid ester) and the like.

In addition, the coenzyme Q includes both reduced and oxidized forms represented by the following formula (2) and (3).

(Reduced form, n = 1-12)

(Oxidized form, n = 1 to 12)

In addition, the fat-soluble vitamins include vitamin A, vitamin D, vitamin E, vitamin K, vitamin P and derivatives thereof.

In addition, the fat-soluble flavoring (mentor), menthol (orange oil) (orange oil), lemon oil (lemon oil), citron oil (Citrus junos oil), essential oil (essential oil) and the like.

The hydrocarbons also include squalene, squalane, lanolin, liquid paraffin, and the like.

The water used in the composition of the present invention is not particularly limited as long as it is water that can be blended in medicine, food, beverage, cosmetics, and feed. For example, purified water such as ion-exchanged water, distilled water, tap water, natural water, and alkaline ionized water. Etc. can be mentioned

The aqueous solution composition of the present invention comprising the composition as described above includes the sucrose fatty acid ester of Formula 1: a fat-soluble substance in a weight ratio of 1: 1 to 4: 1 (8: 2). This content range is a range obtained through various experiments so that the fat-soluble substance can be stably dispersed in water.

At this time, the water is used in the range of 70 to 99.5% by weight in the total aqueous solution composition for the production of a stable dispersion.

As described above, the present invention provides an aqueous solution containing these fat-soluble substances as part of a method for extending the biological utility of fat-soluble substances including coenzyme Q ₁₀ , ceramide, vitamin E acetate, etc. used in the food, pharmaceutical and cosmetic industries. In the process, it is a non-toxic, tasteless, odorless, non-irritating to eyes and skin, and the composition system of sucrose fatty acid ester with the property of decomposing into naturally occurring substance, so that fat-soluble substance can be easily and conveniently received in stable state. It's a new way.

On the other hand, the present invention comprises the steps of mixing the sucrose fatty acid ester of Formula 1 with a fat-soluble material; And adding water to the obtained mixture to prepare an emulsion.

At this time, the mixing is performed with a mixer such as TK Homo Mixer (TOKUSHU KIKA KOGYO Co., Ltd.), M Technique Co., Ltd., Microfluidizer, MIZUHO Industrial Co., Ltd., Ultimizer, etc. Homogenization processor such as (Ultimaizer, Sugino Machine Limited) can be used.

Furthermore, in order to refine | miniaturize and stabilize an aqueous solution composition as needed, it can carry out 2 or more times in parallel with a mixer and a homogenization process.

In addition, it is possible to use homogenizers such as nanomizers and ultrasonic emulsifiers and various homomixers such as AGI homomixers and ultra mixers.

As the method for producing the aqueous solution composition of the present invention, a natural emulsification method, a phase inversion emulsification method, a liquid crystal emulsification method, a gel emulsification method, a D phase emulsification method, a PIT emulsification method, and the like can also be used. Moreover, you may perform combining these methods and mechanical emulsification methods, such as the said homogenization process.

The aqueous solution composition according to the present invention has an average particle diameter of 10 to 800 nm, preferably 100 to 300 nm of the fat-soluble substance, and the size of such particles is sufficient for the storage stability of the aqueous solution composition, the absorbency or transparency to the living body, The objective effect of the present invention can be obtained.

In the case of the aqueous solution composition prepared using coenzyme Q ₁₀ and ceramide according to an embodiment of the present invention, the size of the particles of the coenzyme Q ₁₀ was confirmed to have a nano level of 224 nm and 232 nm, respectively.

In addition, through the preferred embodiments of the present invention, a thin layer chromatography (TLC) and turbidity comparison experiment of the prepared aqueous solution composition did not change the temperature-soluble material was observed.

Therefore, the aqueous solution composition of the reduced coenzyme Q ₁₀ (Formula 2) prepared in the present method can be used for medicine, cosmetics, food, horticultural farming and dairy farming.

Particularly preferred are solutions of injectables, preservation solutions for organ transplantation, infusion solutions (into veins), eye drops, oral administration solutions, lotions, hair tonics, perfumes, etc. I) It can be used for preservation of sprays, aerosols, health drinks, liquid fertilizers, animal feeds, meat / fish / perishable foods, and solution oxidation prevention (solution preservation).

Hereinafter, the present invention will be described in more detail with reference to the following examples, which are illustrative only for explaining the present invention, and the present invention is not limited thereto.

Sucrose mono esters (content of mono-esters>95%; content of di-esters + tri-esters <5%) used in the process were prepared by the method developed by the inventor (Patent No. 0447105). Coenzyme Q ₁₀ was used by Nissin Pharma Inc., ceramide 3 (N-Stearoyl-phytosphingosine, Ceramide3) was used by Doosan Biotech BU, and Vitamin E acetate was used by Sigma. Aldrich Korea Co., Ltd. product was used. In addition, "%" mentioned here means weight% unless there is particular notice.

( Example  One)

After the sucrose monolaurate evenly mixed with a 0.4% by weight of coenzyme Q ₁₀ 0.2% by weight of water was added to 99.4% by weight of 10 ℃ to prepare a uniform aqueous solution was stirred for 30 minutes.

Particle size

The particle size of the prepared fat-soluble material in the aqueous solution was measured by a standard particle size analyzer (MASTERSIZER 2000 by Malvern; measurement range: 0.02 ~ 2000㎛), the results obtained are shown in FIG.

1 is an average particle size distribution of coenzyme Q ₁₀ in an aqueous solution prepared in Example 1. FIG.

Referring to FIG. 1, the average particle diameter of the aqueous solution was found to be 224 nm.

Aqueous solution stability

The composition of Example 1 was warmed to 30 ℃ and observed by thin layer chromatography (TLC) while stirring for 10 days. As a result, no material change in the composition was observed.

( Example  2)

0.4 wt% of sucrose mono laurate and 0.2 wt% of ceramide 3 (N-Stearoyl-phytosphingosine) were evenly mixed, added to 99.4 wt% of water at 10 ° C., and stirred for 1 hour to prepare a uniform aqueous solution.

Particle size

The particle size of the fat-soluble substance in the prepared aqueous solution was measured by a standard particle size analyzer, and the obtained results are shown in FIG. 2.

2 is an average particle size distribution of ceramide 3 in the aqueous solution prepared in Example 2. FIG.

2, the average particle diameter of the aqueous solution was found to be 232 nm.

Aqueous solution stability

After the composition of Example 2 was warmed to 30 ° C. and observed by thin layer chromatography (TLC) while stirring for 10 days, no material change was observed in the solution.

( Example  3)

0.4% by weight of sucrose mono laurate and 0.2% by weight of vitamin E acetate were mixed and then added to 99.4% by weight of water at 10 ° C. and stirred for 1 hour to prepare a uniform aqueous solution.

Particle size

The particle size of the fat-soluble substance in the prepared aqueous solution was measured by a standard particle size analyzer, and the results obtained are shown in FIG. 3.

3 is an average particle size distribution of vitamin E acetate in an aqueous solution prepared in Example 3. FIG.

Referring to FIG. 3, the average particle diameter of the aqueous solution was found to be 701 nm.

Aqueous solution stability

After the composition of Example 2 was warmed to 30 ° C. and observed by thin layer chromatography (TLC) while stirring for 10 days, no material change was observed in the solution.

( Example  4)

Sucrose mono palmitate was added to the lactate 0.4% by weight of coenzyme 99.4% by weight of water of 20 ℃ was mixed evenly Q ₁₀ 0.2% by weight to prepare a uniform aqueous solution was stirred for 1 hour.

After the aqueous solution was warmed to 30 ° C. and observed by thin layer chromatography (TLC) with stirring for 24 hours, no material change was observed in the solution.

( Example  5)

0.4% by weight of sucrose mono palmitate and 0.2% by weight of ceramide 3 (N-Stearoyl-phytosphingosine) were evenly mixed and then added to 99.4% by weight of water at 20 ° C. and stirred for 2 hours to prepare a uniform aqueous solution.

After the aqueous solution was warmed to 30 ° C. and observed by thin layer chromatography (TLC) with stirring for 24 hours, no material change was observed in the solution.

( Example  6)

0.4% by weight of sucrose mono palmitate and 0.2% by weight of vitamin E acetate were evenly mixed, added to 99.4% by weight of water at 20 ° C, and stirred for 3 hours to prepare a uniform aqueous solution.

After the aqueous solution was warmed to 30 ° C. and observed by thin layer chromatography (TLC) with stirring for 24 hours, no material change was observed in the solution.

( Example  7)

Sucrose mono palmitate lactate was 0.28% by weight, and then mixed with sucrose monostearate 0.12% by weight of coenzyme Q ₁₀ 0.20% by weight evenly added to water of 99.4% by weight of 20 ℃ and a uniform solution was stirred for 2 hours.

After the aqueous solution was warmed to 30 ° C. and observed by thin layer chromatography (TLC) with stirring for 24 hours, no material change was observed in the solution.

( Example  8)

0.28% by weight sucrose mono palmitate, 0.12% by weight sucrose monostearate and 0.20% by weight ceramide 3 (N-Stearoyl-phytosphingosine) are added to 99.4% by weight water at 20 ° C. and stirred for 3 hours 30 minutes One aqueous solution was prepared.

After the aqueous solution was warmed to 30 ° C. and observed by thin layer chromatography (TLC) with stirring for 24 hours, no material change was observed in the solution.

( Example  9)

0.28% by weight of sucrose mono palmitate, 0.12% by weight of sucrose monostearate and 0.20% by weight of vitamin E acetate were mixed, and then added to 99.4% by weight of water at 20 ° C and stirred for 4 hours to prepare a uniform aqueous solution.

After the aqueous solution was warmed to 30 ° C. and observed by thin layer chromatography (TLC) with stirring for 24 hours, no material change was observed in the solution.

( Example  10)

Sucrose mono palmitate lactate was 0.12% by weight, and then mixed with sucrose monostearate 0.28% by weight of coenzyme Q ₁₀ 0.20% by weight evenly added to water of 99.4% by weight of 20 ℃ and a uniform solution was stirred for 4 hours.

After the aqueous solution was warmed to 30 ° C. and observed by thin layer chromatography (TLC) with stirring for 24 hours, no material change was observed in the solution.

( Example  11)

0.12% by weight of sucrose mono palmitate, 0.28% by weight of sucrose monostearate and 0.20% by weight of ceramide 3 (N-Stearoyl-phytosphingosine) are added, and then added to 99.4% by weight of water at 20 ° C and stirred for 6 hours to give a uniform aqueous solution. It was prepared.

After the aqueous solution was warmed to 30 ° C. and observed by thin layer chromatography (TLC) with stirring for 24 hours, no material change was observed in the solution.

( Example  12)

0.12% by weight of sucrose mono palmitate, 0.28% by weight of sucrose monostearate and 0.20% by weight of vitamin E acetate were mixed, and then added to 99.4% by weight of water at 20 ° C. and stirred for 6 hours to prepare a uniform aqueous solution.

After the aqueous solution was warmed to 30 ° C. and observed by thin layer chromatography (TLC) with stirring for 24 hours, no material change was observed in the solution.

( Example  13)

Sucrose monostearate 0.4% by weight of coenzyme Q ₁₀ was mixed thoroughly to 0.2% by weight of water was added to 99.4% by weight of 20 ℃ to prepare a uniform aqueous solution was stirred for 8 hours.

After the aqueous solution was warmed to 30 ° C. and observed by thin layer chromatography (TLC) with stirring for 24 hours, no material change was observed in the solution.

( Example  14)

0.4% by weight of sucrose monostearate and 0.2% by weight of ceramide 3 (N-Stearoyl-phytosphingosine) were evenly mixed, added to 99.4% by weight of water at 20 ° C., and stirred for 8 hours to prepare a uniform aqueous solution.

After the aqueous solution was warmed to 30 ° C. and observed by thin layer chromatography (TLC) with stirring for 24 hours, no material change was observed in the solution.

( Example  15)

0.4% by weight of sucrose monostearate and 0.2% by weight of vitamin E acetate were evenly mixed, and then added to 99.4% by weight of water at 20 ° C. and stirred for 8 hours to prepare a uniform aqueous solution.

After the aqueous solution was warmed to 30 ° C. and observed by thin layer chromatography (TLC) with stirring for 24 hours, no material change was observed in the solution.

( Example  16)

Sucrose monooleate was 0.4% by weight of coenzyme Q ₁₀ was mixed thoroughly to 0.2% by weight of water was added to 99.4% by weight of 20 ℃ and a uniform solution was stirred for 6 hours.

After the aqueous solution was warmed to 30 ° C. and observed by thin layer chromatography (TLC) with stirring for 24 hours, no material change was observed in the solution.

( Example  17)

0.4% by weight of sucrose monooleate and 0.2% by weight of ceramide 3 (N-Stearoyl-phytosphingosine) were evenly mixed, and then added to 99.4% by weight of water at 20 ° C. and stirred for 6 hours to prepare a uniform aqueous solution.

After the aqueous solution was warmed to 30 ° C. and observed by thin layer chromatography (TLC) with stirring for 24 hours, no material change was observed in the solution.

( Example  18)

0.4% by weight of sucrose monooleate and 0.2% by weight of vitamin E acetate were evenly mixed, and then added to 99.4% by weight of water at 20 ° C. and stirred for 6 hours to prepare a uniform aqueous solution.

After the aqueous solution was warmed to 30 ° C. and observed by thin layer chromatography (TLC) with stirring for 24 hours, no material change was observed in the solution.

( Example  19)

Sucrose produced the monolaurate 0.8% by weight of coenzyme Q ₁₀ 0.2% by weight of Ceramide 3 (N-Stearoyl-phytosphingosine) a uniform aqueous solution was then mixed uniformly with 0.2% by weight was added to 99.0% by weight of water of 10 ℃ and stirred for 1 hour It was.

After the aqueous solution was warmed to 30 ° C. and observed by thin layer chromatography (TLC) with stirring for 24 hours, no material change was observed in the solution.

( Example  20)

Added to sucrose monolaurate 0.8% by weight of coenzyme Q ₁₀ 0.2% by weight and 99.0% by weight of vitamin E mixed with water of 10 ℃ after evenly from 0.2 weight% acetate and obtain a homogenous solution was stirred for 1 hour.

After the aqueous solution was warmed to 30 ° C. and observed by thin layer chromatography (TLC) with stirring for 24 hours, no material change was observed in the solution.

( Example  21)

0.8% by weight of sucrose monolaurate, 0.2% by weight of N-Stearoyl-phytosphingosine and 0.2% by weight of Vitamin E Acetate were mixed, and then added to 99.0% by weight of water at 10 ° C. and stirred for 1 hour to prepare a uniform aqueous solution. It was.

After the aqueous solution was warmed to 30 ° C. and observed by thin layer chromatography (TLC) with stirring for 24 hours, no material change was observed in the solution.

1 is an average particle size distribution of coenzyme Q ₁₀ in an aqueous solution prepared in Example 1. FIG.

2 is an average particle size distribution of ceramide 3 in the aqueous solution prepared in Example 2. FIG.

3 is an average particle size distribution of vitamin E acetate in an aqueous solution prepared in Example 3. FIG.

Claims (14)

Fat-soluble substances are soluble, Sucrose fatty acid ester represented by Formula 1 below; Fat-soluble substances; And Containing water Aqueous solution composition: [Formula 1]

(In Formula 1, R is-(CH ₂ ) _n H, wherein 5≤n≤21) The method of claim 1, The sucrose fatty acid ester is an aqueous solution composition comprising a single or a mixture of two or more fatty acid n is 5 to 21. The method of claim 1, The fatty acids of the sucrose monoesters are caprylyl (C8) with n of 8, capryl (C10) with n = 10, lauryl (C12) with n = 12, myristyl (C14) with n = 14, n = 16 Aqueous solution composition which is one selected from the group consisting of phosphoryl palmityl (C16), oleyl (C18) with n = 18, stearyl (C18), behenyl (C20) with n = 20 and mixtures thereof. The method of claim 1, The sucrose fatty acid ester is an aqueous solution composition of sucrose mono laurate, sucrose mono palmitate, sucrose mono stearate, sucrose mono oleate alone or mixed two or more kinds. The method of claim 1, The fat-soluble substance is an aqueous solution composition selected from the group consisting of food oils, lipids, coenzyme Q, fat-soluble vitamins, fat-soluble flavors, hydrocarbons (hydrocarbons) or derivatives thereof. The method of claim 5, The food oils include oils made from animals, plants and microorganisms and oils synthesized, lard, beef tallow, chicken oil, whale oil, whale oil, Liver oil, cotton seed oil, safflower oil, rice oil, corn oil, rape seed oil, palm oil, beesteak plant oil, perilla ocimoides oil, cacao butter, peanut oil, coconut oil, evening primrose oil, borage oil, milk fat fat), butter (butter), synthetic triglycerides (triglycerides), and an aqueous solution composition selected from the group consisting of a mixture thereof. The method of claim 5, The lipids include sphingolipids (ceramides, sphingomyelin, glycosphingolipids), octacosanol, phosphatidylserine, phosphatidylcholine, phosphatidylethanolamines, phosphatidyl ethanyl dynosylthiophosphines ), Phytosterol, lycopene, lycopene, beta-carotene, lutein, lutein, SAIB (sucrose acetic acid / isobutyric acid ester) and a mixture thereof. The method of claim 5, The coenzyme Q is an aqueous solution composition comprising a coenzyme Q of the reduced and oxidized form represented by formulas (2) and (3). [Formula 2]

(Reduced form, n = 1-12) [Formula 3]

(Oxidized form, n = 1 to 12) The method of claim 5, The fat-soluble vitamin is an aqueous solution composition that is one selected from the group consisting of vitamin A, vitamin D, vitamin E, vitamin K, vitamin P and derivatives thereof. The method of claim 5, The fat-soluble flavoring agent (flavor) is menthol, orange oil (orange oil), lemon oil (lemon oil), citron oil (Citrus junos oil), essential oils (essential oil) and a mixture thereof Aqueous solution composition. The method of claim 5, The hydrocarbons (hydrocarbons) is an aqueous solution composition that is one selected from the group consisting of squalene (squalene), squalane (squalane), lanolin, liquid paraffin and mixtures thereof. The method of claim 1, The composition is an aqueous solution composition comprising a weight ratio of sucrose fatty acid ester: fat-soluble material of the formula (1) 1: 1 to 4: 1. The method of claim 1, The fat-soluble material is an aqueous solution composition of 10 nm to 800 nm in average particle diameter in the aqueous solution composition. To solubilize fat-soluble substances, Mixing the sucrose fatty acid ester of Formula 1 with a fat soluble material; And Preparing an emulsion by adding water to the obtained mixture A method of solubilizing a fat-soluble substance for preparing the aqueous solution composition of claim 1. [Formula 1]

(In Formula 1, R is-(CH ₂ ) _n H, wherein 5≤n≤21)

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