KR20070111732A - The composition of medical cure and prevention of cancer of every kind , diseases of endocrine system, diseases of obstetrics and pediatrics system, diseases of medial malleolus system, liver disease, inflammatory disease, diseases of immunological system, diseases of circulatory system by the using natural substance - Google Patents

Abstract

A composition comprising natural products is provided to prevent and treat cancer, diseases of endocrine system, diseases of obstetrics and pediatrics system, diseases of medial malleolus system, liver disease, inflammatory disease, disease of immunological system and disease of circulatory system without toxicity. A composition for preventing and treating cancer and other diseases of body systems is prepared by (a) drying and pulverizing Fomes fomentarius Kickx, Phellinus linteus, Inonotus obliquus, cauliflower mushroom, Shepherd's purse and rice straw, (b) mixing the pulverized natural product with enzymes, adding water and fermenting and drying the mixture, (c) pulverizing the fermented mixture, adding various materials into the pulverized product, adding enzymes and water into mixture, and fermenting the mixture, (d) extracting the fermented product with water or organic solvent, and filtering the extracted product, and (e) processing the filtered product into liquid or solid phase.

Description

Composition for preventing and treating circulatory disease, immune system disease, inflammatory disease, liver disease, internal disease, acid, pediatric disease, endocrine disease, viral disease, various cancer diseases using natural products {The composition of medical cure and prevention of cancer of every kind, diseases of endocrine system, diseases of obstetrics and pediatrics system, diseases of medial malleolus system, liver disease, inflammatory disease, diseases of immunological system, diseases of circulatory system by the using natural substance.}

The present invention relates to a composition for the prevention and treatment of circulatory diseases, immune diseases, inflammatory diseases, liver diseases, medical diseases, acids, pediatric diseases, endocrine diseases, viral diseases, various cancer diseases using natural products, and Wood mushrooms, such as mushrooms, horseshoe mushrooms and chaga mushrooms, contain active ingredients in tissues such as chitin, so it is not easy to extract effective ingredients effectively by conventional extraction methods. Significantly falls In particular, beta glucan is known to reduce the levels of fat, sugar, and cholesterol in the blood, strengthen immunity to prevent adult diseases, and to strengthen the human body to naturally cure cancer, diabetes, and high blood pressure.

      The technology produced through the special fermentation method of the present invention extracts active ingredients such as organic germanium, dietary fiber, beta glucan, beta-carotene and various minerals and various amino acids using natural products, and anti-cancer or functional food for improving liver function and anti-cancer or It relates to a composition for improving liver function.

       Horseshoe mushroom (Birch mushroom) is a fungus of the genus Mycobacterium fungi. The scientific name is Fomes fomentarius, and it is a genus of fungi and horseshoe fungi. Distribution area Horseshoe mushrooms grow on the sap from the birch in the harsh regions of minus 20-50 degrees above 45 degrees north latitude. It is 10 to 20 cm thick and 20 to 50 cm in diameter. It grows on hardwoods or trees of hardwoods such as birch, beech and maple. Mushroom caps are semicircular to bell-shaped or horseshoe-shaped. The shade is 10-20cm in diameter and 20-50cm in diameter, but some small species are only 3-5cm in diameter. The surface is grey, thick, covered with hard crusts, grayish brown or dark brown wavy or severely grooved horizontally. The shade is dull and yellowish brown. The epidermis is tan and looks like sturdy fur. The lower side is grey-white, the stem hole is several layers, and there are small holes of dense gray or play yellow. Spores are oval, white-patterned, 16-18 × 5-6μm. A mushroom that causes wood to rot in white.

      In general, when the skin is hard and used for edible or medicinal purposes, it is finely chopped and used in the form of tea. It has antipyretic and diuretic effects, and there are records that Hippocrates also used this mushroom to moisten wounds. The taste is slightly bitter and flat. It is an extremely cold-tolerant mushroom that has great vitality and is a fungus with mushrooms. The herbaceous book describes horseshoe mushrooms as follows: "It is a chemical bacterium, and its origin is various. Ployporaceae is a family of fungi (Fomess fomantarius (Fr. Kickx)), a perennial, a woody plant, ovate, and shaped like a horseshoe. Is 5 ~ 20 × 7 ~ 40cm, thickness is 3 ~ 20cm, and the surface of the gat is smooth and hard, and it shows 灰色 and 내지 色 ~ 紫黑色, with concentric annulus and the periphery of the gat is dull. The tube is of several layers, the order of layers is not clear, each layer is 3-5mm, and it is thinner than the color of the flesh of the homogeneous tube.胞子 is ellipsoidal and colorless. Entariol, fomantaric acid and saponin, etc. Taste is bitter, flat and effective The effect is 消 積, 化瘀, 抗癌 The main treatment is eating pediatric foods, esophageal cancer, stomach cancer, uterine cancer.

Hippocrates, an ancient Greek physician, used this mushroom to moisten wounds and used it for hemostasis and inflammation, and it was said to have been the oldest mushroom when horseshoe mushrooms were excavated from the Stone Age period in 8000 BC. have. In particular, this mushroom contains 1,462 ppm (7 times as much as ginseng) of 'organic germanium (Ge-132)', which is effective for preventing diabetes and adult diseases by releasing waste products and heavy metals in the human body, and affecting the human circulatory and nervous system. It has been reported that it has a great effect on the treatment and prevention of diseases by facilitating metabolism and activating immune function. In addition, 'beta crucan', which is recognized as the main ingredient that has anti-cancer effects, plays a role in inhibiting the development and growth of cancer. . Horseshoe mushrooms are best grown on birch trees because birch trees are used by themselves. Birch bark is called in Chinese medicine and folk medicine, baekhwapi (白樺 皮), hwapi (樺 皮) and is used for the treatment of jaundice, diarrhea, nephritis, pulmonary tuberculosis, gastritis and various carbuncles. Birch bark has a bitter taste and cold nature, which acts on the liver, lowers heat, removes moisture, stops coughing and coughs.It has excellent detoxification and strong anti-inflammatory effects. It can also be used to repair edema. In terms of mineral content of sap components, birch sap is much higher than cypress wood.

        Woody mud mushrooms are taxonomically belonging to the genus Basidiomycotina, Aphyllophorales, and Phellinus Quel. Em. Imaz. It is native to the mulberry stem and is yellow, except for the surface of the hat.

      Situation mushrooms are mushrooms native to the trunks of apple trees, mulberry trees and oak trees in the Chinese Medicine Dictionary (中藥 大 辭典, 上海 科學 技術), such as Sang, Sangsin, Hogoan, etc. Have two people. In addition, there is a difference in

It is recorded in the port of Morus alba L. (桑皮 本), and the Ishijin of Myongdae is located in the main herbaceous wood. It is classified into the terms of (상), 유 (유), ivory (상), 신 (및)) and the situation (桑 黄), and in the Dongbobom (감).桑 耳), the situation (桑 黃) is classified as. Wood muds are Phellinus linteus (Berk. Et Curt) Aoshima, P. igniarius (L. exFr.) Quel, P. yucatensis (Murr.) Imazek, Fomes yucatensis Murrill., Phropolyporus yucatensis Murr. Although it is named in various ways, etc., Phellinus igniarius (Lex Fr.) Quel, which grows in broadleaf trees such as ancestors, sheep, and two people, is widely interpreted. Situation mushroom

Wood mud mushrooms, which are scientific names and true meanings, grow only in mulberry trees, unlike horse mud mushrooms. The scientific name is Phellinus linteus (Berk. Et Curt) Aoshima (原色 日本 菌類 圓 鑑, 1975). .

       Woody mud mushrooms grow on the stump of the mulberry tree, and their shape is initially called yellow mud lumps. . The upper part of the tongue-like shape is slightly different depending on the variety of the situation, but it may be mud-like or blackish like the skin of persimmon.

       The pharmacological action of woody mud mushrooms is gastric cancer, esophageal cancer,

It is known to increase immune function when chemotherapy is performed after resection of liver cancer including duodenal cancer, colon cancer and rectal cancer. It also activates and detoxifies uterine and bleeding, dysmenorrhea, intestinal bleeding, intestinal and gastrointestinal functions.

       Ikegawa et al. (Gann, 59, 155, 1968) reported that woody mud mushrooms had higher tumor inhibition rates than cloud mushrooms (Coriolus versicolor) and shiitake mushrooms (Lent inusedodes), and Protein Nucleic acid Enzyme, 21, 426, 1976) is anticancer

The activity was reported to be 96.7%. Chung et al. (Journal of Pharmaceutical Sciences, 38, 158, 1994) reported that the protein polysaccharide of mycelium effectively suppressed Sarcoma 180 ascites and solid cancer, and Kim et al. (Arch, Pharm. Res., 17, 337, 1994). As a result of analyzing polysaccharides having antitumor activity, it was reported that glucose is mainly composed of glucose, and in addition to galactose, mannose, and arabinose. In addition, Gong et al. (Journal of Pharmacognosy, 22, 233, 1991) showed that the hydrothermal extract of woody mud (situation) mushroom mycelium acts on NK cell function and enhances the host's nonspecific immunity. Reported safety at more than 1,500 mg / kg.

        Chaga is a unique natural mushroom that grows on birch trees by the virus and grows on the sap of birch trees.

Chaga grows natively in the birch woodland of the Taiga climatic zone, which extends extensively from Siberia to North America in Canada and the United States to Scandinavia in Europe. Chaga's scientific name is Inonotus Obliquus, which grows on birch and has names such as Birch Mushroom, Birch Clinker, Polypore, Black Birch Touchwood, Tschagapilz, Clinker Polypore, and Charcoal Shelf. Chaga is a virus that invades birch and fights it, grows in the body of birch for about 10 years, breaks the bark of the tree and comes to the surface, and grows for 10 to 15 years after coming out of the surface. Chaga grows down the root of about 2m in the body of birch and grows by ingesting sap of birch by using the root. Chaga is found not only in birch, but also in alder, hawthorn, willow, and maple rowan. The surface of the grown mushrooms is very rough and black, with many cracks, the inner part is yellowish, with hard, pale yellow leaf veins. In large birches, mushrooms up to 50 cm in diameter are also found. Chaga mushrooms, unlike other mushrooms, have a unique process of engraftment and growth. The dictionary meaning of mushrooms is that “they can't make nutrients by photosynthesis like higher plants, so they can be identified with the eyes among fungi that are parasitic or by-products attached to other organisms or organics. It is a collective term for a group that forms a fruiting body of a certain size. ” Among them, chaga has specificities that distinguish it from common mushrooms in all respects except that they are parasitic on birch trees. Fungi, such as mushrooms, are usually composed of mycelium, which is like the fruit or seed of a mushroom. Chaga, however, is a type of Barren flower that has no mycelia on its growing body. Therefore, it does not reproduce on its own. Common mushrooms grow in mycelium and spores in other organisms or organisms, but chaga are born in the process of fighting the virus that birch penetrates from the outside. Chaga is not a fruiting body, but is made up of 90% of the total fungi and is almost the only mushroom parasitic on living trees. Most of the mushrooms we know are paralyzed from dead wood or tree stumps, and lignin is the main food, while chaga is a living birch, with wood and birch sap as the main food.

         It is a biennial herb of the dicotyledon group Mustardaceae. Its name is Capsella bursa-pastoris, and it is classified as mustard, the temperate zone is the temperate zone, the field is the field and the field, and it grows up to 10-50cm in height. Young sprouts and leaves are herbs that adorn early spring with roots. Naengjik soy sauce is also a real flavor. Also, you can boil and eat namul porridge after slicing the boiled water. Horseradish is also known as naenggi and naengge. It grows in fields or fields. Hairs all over, stems stand straight and branched. The height is 10-50 cm. Root leaves agglomerate and have long petioles, split into feathers, but broad at the ends. Stem leaves are shifted and become smaller as they go up, disappearing petiole, and wrap the stem halfway with basso. White flowers bloom in May-June, with a large number of cruciforms (十字花) to form a gunshot inflorescence. Calyxes are 4, long oval, petals are upside down egg shape, 4 of 6 stamens are long, 1 pistil. Fruits are flat inverted triangles with 25 seeds. Young sprouts and leaves are herbs that adorn early spring with roots. Naengjik soy sauce is also a real flavor. Also, you can boil and eat namul porridge after slicing the boiled water. In oriental medicine, all parts, including the roots of radish, are used as medicinal herbs, which are collected when flowers bloom and dried in the sun or used as raw grass. Dried chops prior to writing. The drug is effective for the spleen and spleen, and it has the effects of diuretic, hemostasis, detoxification, and so on. It is distributed in temperate regions of the world, including Korea. The world is currently committed to developing therapeutics using natural products. In Korea, functional foods and therapeutic agents using natural products are being developed a lot, and beyond the limits of foods using excellent natural products, they are manufactured as functional foods and therapeutic agents using natural products to create high added value as well as to human health. You will be able to contribute.

 Therefore, the technical problem to be achieved by the present invention is to prevent and treat circulatory diseases, immune diseases, inflammatory diseases, liver diseases, internal diseases, acid, pediatric diseases, endocrine diseases, viral diseases, various cancer diseases using natural products The present invention relates to the preparation of the composition for extracting effective ingredients such as beta glucan and beta carotene contained in chitin tissues of situation mushrooms, horseshoe mushrooms and chaga mushrooms, thereby enhancing economic efficiency. In particular, beta glucan is known to reduce the level of fat and sugar and cholesterol in the blood, and to enhance immunity to prevent adult diseases as well as to strengthen the human body to naturally heal cancer, diabetes, hypertension, etc. The technology produced through the special fermentation method extracts active ingredients such as organic germanium, dietary fiber, beta glucan, beta carotene and various minerals and various amino acids using natural products to circulate diseases, immune system diseases, inflammatory diseases, liver diseases, medical systems Circulatory system, immune system disease, inflammatory disease, liver disease, medical disease, acid, pediatric system to prevent and improve diseases, acid, pediatric diseases, endocrine diseases, viral diseases, various cancer diseases Produces the composition for the prevention and treatment of diseases, endocrine diseases, viral diseases and various cancer diseases To provide a rockThere..it.

In order to achieve the above technical problem, the present invention prevents circulatory diseases, immune diseases, inflammatory diseases, liver diseases, internal diseases, acids, pediatric diseases, endocrine diseases, viral diseases, various cancer diseases and the like using natural products A therapeutic composition, comprising: (a) preparing horseshoe mushrooms, situation mushrooms, chaga mushrooms, matsutake mushrooms, wasabi, and crushed rice straw respectively; (b) mixing the milled natural powder and enzyme, followed by primary fermentation by adding water and drying; (c) pulverizing the above materials in a second manner to mix various materials and then adding an enzyme and fermenting with adding water; (d) extracting and filtering the material with water or an organic solvent to obtain an extract; (e) preparing the material in a liquid or solid form to produce it; It provides a method for producing a composition for the prevention and treatment of circulatory diseases, immune diseases, inflammatory diseases, liver diseases, medical diseases, acids, pediatric diseases, endocrine diseases, viral diseases, various cancer diseases using natural products through .

 Hereinafter, a composition for the prevention and treatment of circulatory system diseases, immune system diseases, inflammatory diseases, liver diseases, medical diseases, acids, pediatric diseases, endocrine diseases, viral diseases, various cancer diseases using natural products according to the present invention More specifically, horseshoe mushrooms, mushrooms, chaga mushrooms, matsutake mushrooms, horseradish, rice straw, natural products manufactured from raw materials, circulatory diseases, immune diseases, inflammatory diseases, liver diseases, internal diseases, acid, pediatric diseases As a composition for the prevention and treatment of endocrine diseases, viral diseases, and various cancer diseases can be used as functional foods and preventive and therapeutic agents. Horseshoe mushroom, mushrooms, chaga, matsutake mushrooms, horseradish, rice straw, organic germanium, dietary fiber, beta-glucan, beta-carotene, various minerals and amino acids, etc. Diseases, immune system diseases, inflammatory diseases, liver diseases, medical diseases, acid, pediatric diseases, endocrine diseases, viral diseases, various cancer diseases can be expected to prevent and treat.

          As described above, the prevention of circulatory diseases, immune diseases, inflammatory diseases, liver diseases, internal diseases, acids, pediatric diseases, endocrine diseases, viral diseases, various cancer diseases and the like using natural products produced by the production method of the present invention and The therapeutic composition may not only be manufactured and utilized as a functional food because there is no side effect such as pharmaceutical-specific toxicity, and may contribute to human health by supplementing the harm of various functional foods and pharmaceuticals produced by synthetically emerging globally.

   The resulting composition can be expected to be good as a therapeutic agent for a variety of animals as well as humans.

        A method for preparing a composition for preventing and treating circulatory diseases, immune diseases, inflammatory diseases, liver diseases, internal diseases, acid, pediatric diseases, endocrine diseases, viral diseases, various cancer diseases using natural products of the present invention Looking at it as follows.

       First, horseshoe mushrooms, situation mushrooms, chaga mushrooms, matsutake mushrooms, horseradish, and rice straws are dried and prepared by crushing each of the natural powders and enzymes. The first fermented material is dried, and then crushed in a second manner to mix various materials, followed by addition of enzymes, followed by fermentation by adding water, followed by drying. The dried material is pulverized again in 3rd, extracted with water or organic solvent, filtered and extracted, and then produced in liquid or solid form, circulatory system disease, immune system disease, inflammatory disease, liver disease, medical disease, acid, It provides a method for producing a composition for the prevention and treatment of pediatric diseases, endocrine diseases, viral diseases, various cancer diseases.

        Hereinafter, the present invention will be described in detail with reference to Examples. However, embodiments according to the present invention may be modified in many different forms, and the scope of the present invention should not be construed as being limited to the embodiments described below. The embodiments of the present invention are provided to more completely explain the present invention to those skilled in the art.

will be.

Example 1  Natural Hydrothermal extract  Produce

         Horseshoe mushrooms, situation mushrooms, chaga mushrooms, matsutake mushrooms, wasabi and rice straws were fermented and pulverized according to the above-mentioned manufacturing method, and then 20 liters of distilled water was added to 5 kg of natural products, extracted at 100 ° C. with a high-pressure extractor, filtered and lyophilized Solid content A was obtained.

Example 2  : Preparation of Organic Solvent Extract

        Horseshoe mushrooms, situation mushrooms, chaga mushrooms, matsutake mushrooms, wasabi, and rice straws were fermented and ground by the above-described manufacturing method, and then 5% of 70% ethanol was added to 5KG of natural products, extracted at 90 ° C., filtered and then lyophilized. Solid content B was obtained.

           Experimental Example 1: Toxicity Test on Hot Water Extract

           To determine the toxicity of the natural product extracts of the present invention, the solids prepared in Example 1 were orally administered to Sprague-Dawley Rats once, and then analyzed for toxic symptoms through increase or decrease in body weight and medical symptom observation. It was.

The experimental method is as follows. 95.6g to 110.2g healthy Sprague-Dawley Rats (males) and 87.5g to 105.2g healthy Sprague-Dawley Rats (females) were selected for 24 animals each, and then 6 animals (female: males = 1: 1) as controls. ) Were divided into three groups of three females and three males, and the experiments were performed for the dosage (1000 mg / kg, 3000 mg / kg, 5000 mg / kg).

Fasting for 12 hours before taking Sprague-Dawley Rats, 1000mg / kg, 3000mg / kg, 5000mg / kg was administered by the extract of Example 1 of the present invention, after the weight change of Sprague-Dawley Rats 1, 3 , Every 5, 7, 9, 11, 13 days. Medical symptoms and mortality were observed every hour for 6 hours after oral administration and once daily for up to 14 days. After 14 days, the animals were sacrificed and each organ and tissue were removed and examined.

As a result, Sprague-Dawley Rats died after administration of the extract of Example 1 at 1000 mg / kg, 3000 mg / kg, 5000 mg / kg, and no other medical symptoms or side effects were observed. Did not appear. The extract of Example 1 was confirmed that no toxicity at 5000mg / kg or less when administered orally.

          Experimental Example 2: Toxicity Test on Organic Solvent Extract

          To determine the toxicity of the natural product extracts of the present invention after the oral administration of the solids prepared in Example 2 to Sprague-Dawley Rats once or after the increase or decrease of body weight, medical symptoms observation, etc. It was.

The experimental method is as follows. 95.6g to 110.2g healthy Sprague-Dawley Rats (males) and 87.5g to 105.2g healthy Sprague-Dawley Rats (females) were selected for 24 animals each, and then 6 animals (female: males = 1: 1) as controls. ) Were divided into three groups of three females and three males, and the experiments were performed for the dosage (1000 mg / kg, 3000 mg / kg, 5000 mg / kg).

Sprague-Dawley Rats were fasted for 12 hours before administration, and 1000 mg / kg, 3000 mg / kg, and 5000 mg / kg of the extract of Example 2 of the present invention were administered, and the weight change of Sprague-Dawley Rats 1, 3 after administration. , Every 5, 7, 9, 11, 13 days. Medical symptoms and mortality were observed every hour for 6 hours after oral administration and once daily for up to 14 days. After 14 days, the animals were sacrificed and each organ and tissue were removed and examined. As a result, none of the Sprague-Dawley Rats died after administration of the extract of Example 1 at 1000 mg / kg, 3000 mg / kg, and 5000 mg / kg, and no other medical symptoms or side effects were observed. Did. The extract of Example 1 was confirmed that no toxicity at 5000mg / kg or less when administered orally.

Thus, the composition for the prevention and treatment of circulatory disease, immune system disease, inflammatory disease, liver disease, medical disease, acid, pediatric disease, endocrine disease, viral disease, various cancer diseases using natural products of the present invention is horseshoe It is an active ingredient of natural germanium, dietary fiber, beta glucan, beta-carotene, which is made from mushrooms, situation mushrooms, chaga, blossom mushrooms, wasabi and rice straws. Various functional foods and pharmaceuticals produced synthetically, which can be expected to prevent and treat inflammatory diseases, liver diseases, medical diseases, acids, pediatric diseases, endocrine diseases, viral diseases, and various cancer diseases. It can contribute to human health as a therapeutic substance complemented to the harm of

Claims (5)

       (a) a step of drying horseshoe mushrooms, situation mushrooms, chaga mushrooms, matsutake mushrooms, wasabi and rice straws, respectively, and then crushed.         (b) mixing the ground natural powder and enzyme, followed by fermentation by adding water and drying.         (c) pulverizing the above material by secondary grinding, mixing various materials, adding enzyme and adding moisture.         (d) extracting and filtering the material with water or an organic solvent to obtain an extract.         (e) circulatory system diseases, immune system diseases, inflammatory diseases, liver diseases, medical diseases, acids, pediatric diseases, endocrine diseases, viruses Method for producing a composition for the prevention and treatment of the nature disease, various cancer diseases. Composition produced by the method of claim 1 Functional food processed with the composition of claim 2 as a raw material and therapeutic and preventive medicine The method of separating and purifying the composition of claim 2 and preparing a compound library using the purified compound, the library prepared as described above and the circulatory system disease, immune system disease, inflammatory disease, liver disease, internal medicine using the natural product using the library Systemic diseases, acid, pediatric diseases, endocrine diseases, viral diseases, various cancer diseases therapeutic substances (以上). Novel materials produced by the process of claim 4