KR20070085478A - Detergent compositions - Google Patents

Abstract

Detergent compositions comprising high efficiency lipase enzymes and particles comprising encapsulated perfumes. Preferred perfumes have a boiling point at 760 mm Hg, of 260°C or lower and a calculated CLogP of at least 3.0. The encapsulated perfume particles are useful in laundry compositions in order to provide efficacious perfume delivery at all stages of the wash, particularly during the laundering stage.

Description

Detergent compositions

The present invention relates to detergent compositions, in particular laundry detergent compositions, in particular detergents comprising lipase or lipase enzymes.

Background of the Invention and Prior Art

Lipase enzymes have been used in detergents since the late 1980s for the removal of fatty contaminants. Lipase enzymes are known to affect the perfume of detergent compositions containing them. Selection of fragrances for use in detergent compositions containing lipase enzymes is disclosed in European Patent Publication No. 430315, in which at least 25% by weight of fragrance material and carbon number are defined in order to counteract the odor caused by the use of lipase enzymes. It has been described that perfumes comprising less than 50% by weight of esters derived from fatty acids of 1 to 7 should be used.

Until relatively recently, the major lipase enzymes on the market worked particularly effectively at lower water contents during the drying phase of the washing process. More recently, however, more efficient lipases have been developed that work effectively during the washing phase of the cleaning process. Examples of such enzymes are as described in WO 00/60063 and Research Disclsoure IP6553D. This makes it much more difficult for detergent formulators to produce a fragrance that consumers are satisfied with in an increasingly climate of consumer expectations for a pleasant fragrance at all stages of the cleaning process. One particular part where the effect of lipase on the perfume in the detergent composition may be most noticeable to the consumer is after storage, and as a result, during the cleaning process. This can be a particular problem in detergents for use in the hand washing process. We have found that the problem described above can be alleviated even in detergent formulations containing new high efficiency lipase enzymes. In addition, the inventors have found certain preferred fragrances for use in such detergent formulations.

Definition of Invention

The present invention

At least 90% identity with wild-type lipases derived from Humicola lanuginosa strain DSM 4109 (a) and electrically neutral at the surface of the three-dimensional structure within 15 E of E1 or Q249 compared to wild-type lipases (B) comprises a peptide adduct at the C-terminus, (c) includes a peptide adduct at the N-terminus, and / or comprises a substitution of a negatively charged amino acid with a positively charged amino acid; d) a negative amino acid at position E210 of wild-type lipase, (i) a negatively charged amino acid in a region corresponding to positions 90-101 of wild-type lipase, and (ii) a position corresponding to N94 of wild-type lipase Have a net charge that is either neutral or negative in the region corresponding to a neutral or negative amino acid and / or in a region corresponding to positions 90-101 of the wild type lipase (iii) Is (e), the lipase is a polypeptide has the amino acid sequence (1) and

A detergent comprising at least one water soluble hydroxyl compound, preferably encapsulated fragrance particles (2) comprising at least partially water soluble solid matrix (a) comprising starch and fragrance oil (b) encapsulated by the solid matrix. To provide a composition.

Lipase enzymes can be polypeptides as defined above and meet the criteria of (a), (b) and (c) and / or (e).

In a further embodiment of the invention, the encapsulated fragrance oil has 1% by weight of at least one fragrance component having a boiling point of 260 ° C. or less at 36 KN / m 2 (760 mmHg) and a log ₁₀ (ClogP) calculated value of octanol / water coefficient P of at least 3.0 At least 5%, or even at least 10%, or even at least 20%, at least 30%, at least 40%, at least 50%, at least 60%, at least 70%, at least 80% Or 90% by weight or more. In further embodiments, the encapsulated fragrance oil generally comprises at least 1 wt% or at least 5 wt%, based on the total weight of the fragrance oil in the encapsulated fragrance particles, with one or more esters derived from fatty acids having 1 to 7 carbon atoms, or Even at least 10 weight percent, or even at least 20 weight percent, at least 30 weight percent, at least 40 weight percent, at least 50 weight percent, at least 60 weight percent, at least 70 weight percent, at least 80 weight percent or at least 90 weight percent. The inventors have found that the present invention is particularly beneficial when the encapsulated fragrance oils comprise benzyl acetate and / or phenylethyl acetate because two specific fragrance esters are particularly sensitive to the presence of the lipase enzyme.

In a further embodiment of the present invention, there is provided a detergent composition comprising a fragrance composition containing fragrance oil in the encapsulated fragrance particles and any additional fragrance oil, wherein the fragrance composition has a molecular weight of greater than 0 Daltons up to 350 Daltons. Contains at least 10%, or at least 20%, at least 30%, at least 40%, at least 50%, at least 60%, at least 70%, at least 80% or even at least 90% At least 80% of the one or more fragrance components have a cLogP of at least 2.4 and the fragrance composition contains at least 5% of at least one fragrance component with a cLogP of at least 2.4.

Unless stated otherwise, all percentages and ratios herein are calculated by weight. Unless stated otherwise, percentages and ratios are calculated based on the total composition. For example, the nomenclature used herein to describe enzymes with respect to amino acid modifications, amino acid classifications, and amino acid identities is as described in WO 00/60063.

Lipase enzymes suitable for use in the present invention are enzymes which can hydrolyze ester bonds and are classified as EC number 3.1, preferably groups consisting of enzymes which hydrolyze carboxylic ester bonds and are classified as EC number 3.1.1. Can be selected from. Particularly preferred of these are lipases classified under EC number 3.1.1.3 and most preferred are those having a first washing performance, for example WO 00/60063, WO 99/42566, WO 02/062973, WO 97/04078, WO 97/04079, and US Pat. No. 5869438.

Preferred lipase enzymes are described in WO 00/60063. Preferred lipases for use in the invention described in WO 00/60063 are described with respect to lipases, wild type lipases (reference lipases) derived from DSM 4109 from Fumico lanuginosa. Reference lipases are also called Lipolase (registered trade name of Novozymes). It is described in European Patent No. 258068 and European Patent No. 305216 and has the amino acid sequence exemplified at positions 1-269 of SEQ ID NO: 2 of US Pat. No. 5869438.

The first preferred lipase for use in the present invention is available under the tradename LIPEX (registered tradename of Novozymes), which is a variant of Fumico lanuginosa, having mutations T231R and N233R. Lipase from Thermomyces lanuginosus (registered trademark "Lipolase" of Novozymes).

Lipase enzymes incorporated into the detergent compositions of the present invention are generally present in amounts of 10 to 20000 LU or 100 to 10000 LU per gram of detergent composition. LU units for lipase activity are defined in WO 99/42566. The amount of lipase to the wash liquor is typically 0.02 to 2 mg / l, more typically 0.1 to 2 mg / l, as the enzyme protein.

Lipase enzymes may also be incorporated into the detergent composition in any convenient form, generally in the form of dust-free granules, stabilizing liquids or coated enzyme particles. Otherwise, the slurry may be suitable.

At least partially water soluble hydroxyl compounds useful in the present invention are preferably selected from carbohydrates, the carbohydrates being simple sugars (or monosaccharides) (i), oligosaccharides (defined as carbohydrate chains consisting of 2 to 10 monosaccharide molecules). (ii), any of polysaccharides (defined as carbohydrate chains of at least 11 monosaccharide molecules or more generally at least 35) (iii) and starch (iv), or mixtures thereof.

Both linear and branched carbohydrate chains can be used. In addition, chemically modified starches and polysaccharides / oligosaccharides can be used. General modifications include adding hydrophobic moieties in the same form as alkyl, aryl, and the like found in surfactants to impart surfactant to the compounds.

Other examples of suitable encapsulating materials include all natural or synthetic rubbers such as alginate esters, carrageenan, agar-agar, pectic acid, and natural rubbers such as gum arabic, tragacanth Rubber and karaya rubber, chitin and chitosan, cellulose and cellulose derivatives (cellulose acetate and cellulose acetate phthalate (CAP) (i), hydroxypropyl methyl cellulose (HPMC) (ii), carboxymethylcellulose (CMC) (iii) and All enteric / aquateric coatings (iv)), and mixtures thereof.

Particularly preferred encapsulation matrix materials include starch. Suitable examples include modified starches derived from raw starch, pregelatinized starch, tubers, legumes, cereals and grains such as corn starch, wheat starch, rice starch, waxy starch, Oat starch, cassava starch, waxy barley, glutinous rice starch, sweet rice starch, amioka, potato starch, tapioca starch, oat starch, cassava starch and mixtures thereof.

Modified starches suitable for use as encapsulation matrices in the present invention include hydrolyzed starches, starch diluted with acids, starch esters of long chain hydrocarbons, starch acetate, starch octenyl succinate and mixtures thereof.

By “hydrolyzed starch” is meant an oligosaccharide based material which is usually obtained by hydrolysis of starch, preferably corn starch, by acid and / or enzymes. Hydrolyzed starch suitable for inclusion in the present invention includes maltodextrin and corn syrup solids. Hydrolyzed starch for inclusion with a mixture of starch esters has a Dextrose Equivalent (DE) value of about 10 to about 36 DE. The DE value is a measure of the reducing equivalent of hydrolyzed starch, expressed in percent (based on dry weight), relative to dextrose. The higher the DE value, the more reducing sugars are present. Methods of determining DE values are described in Standard Analytical Methods of the Member Companies of Corn Industries Research Foundation, 6th ed. Corn Refineries Association, Inc. Washington, DC 1980, D-52.

Starch esters having a degree of substitution in the range of about 0.01 to about 10.0% may be used to encapsulate the fragrance oil of the present invention. The hydrocarbon portion of the modified ester should be a C ₅ to C ₁₆ carbon chain. Preferably, various types of octenylsuccinate (OSAN) substituted waxy corn starch, for example, clay starch (1) diluted with acid and OSAN substituted, starch, OSAN substituted, dextrinized corn syrup solids Blend of (2), OSAN substituted and dextrinized clay starch (3), corn syrup solids or maltodextrin, and a mixture of diluted and OSAN substituted, cooked and spray dried clay starch (4), diluted with acid And / or OSAN-substituted, then cooked and spray-dried waxy starch 5 and variants 6 of high or low viscosity (based on acid treatment levels) may also be used in the present invention.

Modified starches, such as starch octenyl succinate, having emulsifying and emulsion stabilizing capabilities, have the ability to entrap fragrance droplets in emulsions due to the hydrophobic nature of the starch modifiers. The fragrance oil remains trapped in modified starch until dissolved in the wash liquor, due to the stabilization and hydrophobic interaction of the emulsion due to thermodynamic factors, ie steric hindrance. The fragrance may be adsorbed or absorbed by the carrier prior to encapsulation. Suitable examples of carriers are as described in WO 97/11151 or the examples may be polymeric materials. For example, zeolites are particularly preferred carriers, as described in more detail in WO 97/11151.

Other known methods of making starch capsules of the present invention include, but are not limited to, fluidized bed flocculation, extrusion, cooling / crystallization, and the use of phase transfer catalysts to promote interfacial polymerization.

Details of other suitable matrix materials and processes are disclosed, for example, in US Pat. No. 3,971,852 to Brenner et al., Issued July 27, 1976.

Fragrance

As used herein, "perfume oil" is intended to refer to a perfume raw material or ingredient or combinations thereof. They are generally immiscible with water under temperature and pressure at standard conditions, although minority may be miscible with water. The perfume oil may comprise one perfume component or a mixture of one or more perfume components. In addition to the fragrance oils present in the detergent compositions of the present invention via encapsulated fragrance particles, additional fragrance oils may be present in the detergent via other delivery systems, as discussed below. The total fragrance component present in the encapsulated fragrance oil and any additional fragrance oils provides the fragrance composition of the detergent composition.

We often find that lipase enzymes, particularly high efficiency lipase enzymes essential to the present invention, are a problem for the stability of the perfume upon storage, which not only reduces the aroma of the perfume as perceived by the consumer, but also reduces the amount of perfume added to the detergent formulation. It was found that it could have a negative effect on the manufacturer's choice. This problem is particularly noticeable by the consumer during the washing process, and the inventors found that the encapsulated fragrance is not only somewhat protected when stored, but surprisingly, the encapsulated fragrance is chaperoned to the surface of the wash water by the encapsulation. It was found that it appears to provide maximum efficacy to the perfume raw materials used. Combining encapsulated fragrances with the specified lipases also protects some of these fragrance raw materials, particularly those that are sensitive to lipases.

Preferably, the fragrance oil present in the encapsulated fragrance particles comprises one or more fragrance components characterized by boiling point (B.P.) and octanol / water partition coefficient (P). The octanol / water partition coefficient of the perfume component is the ratio between its equilibrium concentration in octanol and its equilibrium concentration in water. Preferred fragrance components of the present invention have a BP measured at a general standard pressure of about 760 mmHg of about 260 ° C. or less, preferably less than about 255 ° C., more preferably less than about 250 ° C., and an octanol / water partition coefficient P of about More than 1,000. Since the partition coefficient of the preferred perfume component of the present invention has a high value, the partition coefficient is more conveniently given in the form of log base 10, logP. Thus, preferred perfume components of the present invention have a logP of at least 3, preferably greater than 3.1, even more preferably greater than 3.2.

Boiling points of many perfume components are given, for example, in "Perfume and Flavor Chemicals (Aroma Chemicals)," Steffen Arctander, published by the author, 1969, which is incorporated herein by reference. do.

A logP of a number of fragrance components has been reported, for example, Pomona 92 (available from Daylight Chemical Information Systems, Inc., Daylight CIS), Irvine, CA. The Pomona92 database contains a large number of references with reference to the original literature, however, the logP values can be most conveniently calculated with the "CLOGP" program, also available from Daylight CS, which is available when available from the Pomona92 database. The experimental logP values of are also listed: "Calculated logP" (ClogP) is a fragmentary approach of Hansch and Leo (A. Leo, in Comprehensive, incorporated herein by reference). Medicinal Chemistry, Vol. 4, C. Hansch, PG Sammens, JB Taylor and CA Ramsden, Eds., P. 295, Pergamon Press, 1990]. C. The fragmentary approach is based on the chemical structure of each perfume component, taking into account the number and type of atoms, atom connectivity and chemical bonds. The approximate ClogP value is preferably used instead of the experimental logP value in the selection of perfume components useful in the present invention.

Thus, when a perfume composition comprising B.P. of about 260 ° C. or less and ClogP or experimental logP of about 3 or more is used in the detergent composition, the perfume is very well ejected and very prominent in use of the product. Table 1 provides some non-limiting examples of preferred perfume components useful in the detergent composition of the present invention. Particularly preferred fragrance oils for encapsulation are octyl aldehyde, nonyl aldehyde, decyl aldehyde, dodecyl aldehyde (dodecaneal or laurate aldehyde), diphenyl oxide, alpha-ionine, Lilial and alpha-iso "gamma" "One component selected from methyl ionone or a mixture of one or more components selected from these. They have been found to be particularly useful for masking odors resulting from the odors of fatty acids. These particularly preferred fragrance oils can be encapsulated alone, encapsulated as part of a mixture with other preferred (ie, listed in Table 1) or particularly preferred fragrance oils, or as part of a mixture with other fragrance oils.

The fragrance oil in the encapsulated fragrance particles may be adsorbed or absorbed by the carrier prior to encapsulation. Suitable carriers are described in WO 97/11151. Particularly preferred carriers are zeolites.

The detergent composition of the present invention contains about 0.01 to 50% encapsulated fragrance particles. More preferably, the detergent composition of the present invention contains 0.05 to 8.0%, even more preferably 0.5 to 3.0% of encapsulated perfume particles. Most preferably, the detergent composition of the present invention contains 0.05-1.0% encapsulated fragrance particles. The encapsulated fragrance particles are preferably 1 to 1000 μm in size, more preferably 50 to 500 μm.

The fragrance oils and / or fragrance compositions are generally present in the compositions of the present invention in an amount of 0.001 to about 5%, preferably 0.01 to 5%, more generally 0.05 to 3%. When present in the detergent composition of the present invention, the preferred perfume component may comprise 100% fragrance oil, but more generally is used in addition to other perfume components. There may be one or more preferred perfume components, for example a mixture of two or more or even five or more, six or more or seven or more different preferred perfume components. In addition, the encapsulated fragrance particles may be at least 1 wt%, at least 5 wt%, at least 10 wt% or even at least 20 wt%, at least 30 wt%, at least 40 wt%, at least 50 wt%, at least 60 wt%, 70 wt%. It may also comprise at least%, at least 80% or at least 90% by weight of such preferred perfume components.

The most common fragrance components derived from natural or synthetic sources consist of a number of components. For example, orange terpenes contain about 90 to about 95% of d-limonene, but also many other minor ingredients. When each such material is used in the preparation of the fragrance oil in the present invention, the material is regarded as one component for the purpose of defining the present invention.

In addition to the encapsulated fragrance oils, the present detergent compositions may comprise additional fragrance oils, which form part of the overall fragrance composition in the detergent composition. The additional fragrance oil may be incorporated into the detergent composition by any other delivery method, for example by simply spraying onto or onto the finished detergent composition and then mixing to form the finished detergent composition.

Encapsulated fragrance particles may also include fragrance oils comprising esters derived from fatty acids having 1 to 7 carbon atoms. If the detergent composition further contains additional fragrance oils, preferably at least 60% by weight, at least 80% by weight or at least 90% by weight or substantially all esters derived from fatty acids having 1 to 7 carbon atoms are present in the encapsulated fragrance particles. will be.

In a further aspect of the invention, the encapsulated oil and / or fragrance composition in the detergent composition has a molecular weight greater than 0 Daltons up to 350 Daltons, about 100 to about 350 Daltons, about 130 to about 270 Daltons, or even about 140 to about 230 At least 10%, at least 20%, at least 30%, at least 40%, at least 50%, at least 60%, at least 70%, at least 80% or even at least 90% of at least one fragrance component that is Dalton; At least 80%, at least 85%, at least 90% or even at least 95% of the one or more perfume ingredients have a cLogP of at least 2.4, from about 2.75 to about 8.0 or even from about 2.9 to about 6.0, and the perfume composition has a cLogP of at least 2.4 At least 5%, at least 15%, at least 25%, at least 35%, at least 45%, at least 55%, at least 65%, 75, of the at least one fragrance component in the range of about 2.75 to about 8.0 or even about 2.9 to about 6.0. At least 85%, at least 85% or even at least 95%. In said embodiment of the invention said at least one fragrance component may be selected from the group consisting of Schiff's base, ether, phenol, ketone, alcohol, ester, lactone, aldehyde, nitrile, natural oil or mixtures thereof. Schiff base and nitrile may be least preferred. In certain embodiments of the invention described above, the one or more perfume components may comprise the perfume component or mixtures thereof in Table 2 or even the perfume components 1 to 28 or mixtures thereof in Table 2. Ketones and aldehydes may preferably have a molecular weight of less than 200 Daltons.

In another embodiment of the invention, the perfume composition comprises at least 10%, at least 20%, at least 30%, at least 40%, at least 50%, of a perfume component selected from the group consisting of the components listed in Table 2 and mixtures thereof, At least 60%, at least 70%, at least 80% or even at least 90%.

In any of the embodiments described above, when the fragrance oil or fragrance composition comprises an ester fragrance component, the ester fragrance is branched at one or more of the alpha, beta or gamma positions when the fragrance oil or fragrance composition comprises an ester fragrance component. Or pendant rings; Branched or pendant rings in one or more of the alpha or beta positions; Or one or more features such as one or more tertiary carbon atoms in the alpha position. Without wishing to be bound by theory, the above-mentioned perfume esters are characterized by the presence of enzymes capable of hydrolyzing ester bonds, for example in the presence of an EC 3.1.1 class of enzymes such as lipases. It is believed that the stability of the perfume ester is thereby increased, thus increasing the stability of the perfume composition.

In any of the embodiments described above of the invention, the fragrance oil or fragrance composition typically comprises acetic acid, phenylmethyl esters; Benzene ethanol; Butanoic acid, 2-methyl-, ethyl ester; 4H-pyran-4-one, 2-ethyl-3-hydroxy-; Benzaldehyde, 4-hydroxy-3-methoxy-; Benzaldehyde, 3-ethoxy-4-hydroxy-; 3-hexen-1-ol, acetate, (Z)-; Butanoic acid, 2-methyl-, 1-methylethyl ester; 3-decanone, 1-hydroxy-; 2-heptanone; Benzaldehyde; Propanenitrile, 3- (3-hexenyloxy)-, (Z)-; 2-butanone, 4-phenyl-; 2-hexen-1-ol; It contains up to about 5% or no perfume components selected from the group consisting of 2 (3H) -furanone, 5-butyldihydro-.

Process for preparing perfume composition

The perfume composition of the present invention may be prepared by mixing the perfume raw materials, which are typically liquid. Certain perfume raw materials are solid materials and may require mild heating to homogenize with the remaining perfume. Perfume blends may also include significant proportions of diluents (eg, dipropylene glycol), antioxidants or solubilizing materials. Solubilizers can be particularly advantageous when surfactant levels are lowered to disperse fragrances in predominantly hydrophilic matrices such as aqueous liquid detergents.

Air freshener delivery method

Any of the foregoing aspects of the fragrance composition may be combined with other materials to produce any of the following delivery systems for delivering additional fragrance oil into the detergent composition: spray-on sprayed directly onto the detergent composition or components thereof. -on) fragrance oils, starch capsule delivery systems, porous carrier mass transfer systems, coated porous carrier mass transfer systems, microcapsule delivery systems. Preferably the detergent composition of the present invention will comprise a capsule and a spray-on fragrance. Suitable methods of making the aforementioned delivery systems include one or more US Pat. No. 6,458,754, US Pat. No. 5,656,584, US Pat. No. 6,172,037, US Pat. No. 5,955,419, US Pat. No. 5,691,383, International Publication It can be found in WO 94/28017, WO 98/41607 and WO 98/52527. Such delivery systems may be used alone, in combination with others, or in combination with the neat spray-on or mixed perfume compositions of the present invention in the form of consumer products.

In addition to lipase enzymes and encapsulated fragrance particles, the detergent compositions of the present invention will also contain one or more conventional detergent components and / or detergent auxiliary components.

Selective detergent supplements

Detergent compositions of the present invention may be any non-aqueous liquid, including any convenient form, such as powdered or granular solids, bars, tablets, or gels and pastes. Other forms of cleaning compositions include other commercial and / or household cleaning compositions, such as liquid or solid cleaning and disinfectants (including antibacterial cleaners), vehicle or carpet shampoos, denture cleaners, hard surface cleaners, such as Cleaning compositions for kitchen and / or bathrooms for selective metal cleaning, hair shampoos, shower gels, bath foams, cleaning aids such as bleach additives and cleaning compositions in a "stain stick" or pretreated form. It includes. The detergent composition of the present invention when present in granular form preferably has a total bulk density of 350 to 1200 g / l, more preferably 450 to 1000 g / l or 500 to 900 g / l. Preferably, the detergent particles of the detergent composition in the form of granules have an average particle size of 200 to 2000 μm, preferably 350 to 600 μm.

In general, the detergent compositions of the present invention will be mixed with other detergent particles, including combinations of aggregates, spray dried powders and / or dry added substances such as bleach, enzymes and the like.

As a preferred embodiment, the conventional detergent component is selected from conventional detergent composition components such as detergent surfactants and detergent builders. Optionally, the detergent component may include one or more other detergent aids or other materials to aid or enhance the cleaning action, to treat the substrate to be cleaned, or to modify the aesthetic properties of the detergent composition. Common detergent auxiliaries for detergent compositions include the components shown in U.S. Patent Nos. 3,936,537 to Baskerville et al. And British Patent Application No. 9705617.0 to Trin et al., Published September 24, 1997. . Such adjuvants are contained in the detergent composition at levels of use established in the prior art, generally from 0 to about 80%, preferably from about 0.5 to about 20% of the detergent component, and include color speckles, foam enhancers, foams. Inhibitors, discolorants and / or corrosion inhibitors, contaminant suspensions, antifouling agents, dyes, fillers, optical brighteners, fungicides, alkaline sources, hydrotrope, antioxidants, enzymes, enzyme stabilizers, solvents, solubilizers, chelates Agents, clay contaminants / antideposition agents, polymer dispersants, processing aids, fabric softeners, static control agents, bleaches, bleach activators, bleach stabilizers, and the like.

As described above, detergent compositions containing particles of the present invention may comprise at least some common detergent auxiliary substances, such as aggregates, injections, other spray dried particles of different composition from the present invention, or dry additions. Will contain the substance. Typically, surfactants are incorporated with solid materials, generally builders, into agglomerates, injection bodies or spray dried particles, which may be mixed with the spray dried particles of the present invention. However, as described above, the solid material may be partially or wholly replaced by the particles of the present invention.

Such detergent aids are typically detergent detergents, builders, polymeric co-builders, bleaches, chelating agents, enzymes, anti-deposition polymers, antifouling polymers, polymeric contaminant dispersions and / or contaminant suspensions. , Otitis inhibitors, fabric integrity agents, foam inhibitors, fabric softeners, flocculants, fragrances, whitening agents, photobleaches and combinations thereof.

The exact nature of these additional ingredients and the level of incorporation thereof will depend on the physical form of the composition or ingredient and the exact nature of the cleaning operation in which it is used.

Very preferred auxiliary components are surfactants. Preferably, the detergent composition contains one or more surfactants. Typically, the detergent composition contains one or more surfactants, based on the weight of the composition, from 0 to 50%, preferably 5%, more preferably 10 or 15 to 40%, 30% or 20%. . Preferred surfactants are anionic surfactants, nonionic surfactants, cationic surfactants, zwitterionic surfactants, amphoteric surfactants, cationic surfactants and mixtures thereof.

Preferred anionic surfactants include one or more residues selected from the group consisting of carbonates, phosphates, sulfates, sulfonates and mixtures thereof. Preferred anionic surfactants are C _{8 -18} alkyl sulfates and C _{8 -18} alkyl sulfonate. Further suitable anionic surfactants include, C ₈ to be incorporated alone or in a mixture form in the compositions of the present invention _{- 18} alkyl sulfate and / or C _{8 - 18} alkyl sulfonate 1 to 9mol of C _{1 -4-alkylene} oxide per 1mol and optionally condensed with a C _{8 - 18} alkyl sulfonate is _{- 18} alkyl sulfate and / or C _8. Comprises at least one branched alkyl group of ₆ parts _- C _{8 - 18} alkyl sulfate and / or C _{8 - 18} alkyl chain of the alkyl sulfonate is a linear or may be of branched, preferred branched alkyl chain C _1. Other preferred anionic surfactants are C _{8 - 18} alkyl benzene sulfates and / or C _{8 - 18} alkyl benzene sulfonate. ₁₈ is an alkyl chain of the alkylbenzene sulfonate is a linear or may be of branched, preferred branched alkyl chains comprise one or more branched portions of C _{1 -6} alkyl group _- C _{8 - 18} alkyl benzene sulfates and / or C ₈ .

Other preferred anionic surfactants are C _{8 - 18} alkenyl sulfates, C _{8 - 18} alkenyl sulfonates, C _{8 - 18} alkenyl benzene sulphate, C _{8 - 18} alkenyl benzene sulfonate, C _{8 - 18} alkyl dimethyl benzene sulfates, C _{8 - 18} alkyl is selected from dimethyl sulfonate, a fatty acid ester sulfonate, a dialkyl sulfosuccinate, and the group consisting of a combination thereof. Anionic surfactants may be present in salt form. For example, anionic surfactants include C _{8 - 18} alkyl sulfates, C _{8 - 18} alkyl sulfonates, C _{8 - 18} alkyl benzene sulphate, C ₈ -C ₁₈ alkyl benzene sulfonate selected from the group consisting of a combination thereof It may also be an alkali metal salt of one or more compounds. Preferred alkali metals are sodium, potassium and mixtures thereof. Typically, the detergent composition contains 10-30% by weight of anionic surfactant.

Preferred nonionic surfactants include C _{8 - 18} from 1 to 9mol C ₁ -C ₄ per 1mol alcohol alkylene oxide with the condensed C _{8 - 18} alcohols, C _{8 - 18} alkyl, NC _{1 - 4} alkyl article erucamide, C _{8 - 18} C _{1 -4} amido dimethylamine, C _{8 - 18} are selected from alkyl poly glycosides, glycerol monoethers, polyhydroxy amides, and the group consisting of a combination thereof. Typically, the detergent composition of the present invention contains 0 to 15, preferably 2 to 10% by weight of nonionic surfactant.

Preferred cationic surfactants are quaternary ammonium compounds. Preferred quaternary ammonium compounds include mixed chains of hydrocarbon long and short chains, typically alkyl and / or hydroxyalkyl and / or alkoxylated alkyl chains. Typically, the long chain hydrocarbon is a C _8-18 alkyl chains and / or C _{8 - 18} is the alkoxylated alkyl chains _{- 18} hydroxyalkyl chains and / or C _8. Typically, the short chain hydrocarbon group is C _{1 - 4} are alkoxylated alkyl chains _{- 4} alkyl chains and / or C _{1 - 4} hydroxyalkyl chains and / or C _1. Typically, the detergent composition contains 0 to 20% of cationic surfactant, based on the weight of the composition.

Preferred zwitterionic surfactants include one or more quaternized nitrogen atoms and one or more moieties selected from the group consisting of carbonates, phosphates, sulfates, sulfonates and combinations thereof. Preferred zwitterionic surfactants are alkyl betaines. Another preferred zwitterionic surfactant is alkyl amine oxide. Cationic surfactants, which are complexes comprising cationic surfactants and anionic surfactants, may also be included. Typically, the molar ratio of cationic surfactant to anionic surfactant in the complex is greater than 1: 1 so that the complex has a net positive charge.

Further preferred auxiliary components are builders. Preferably the detergent composition contains builders from 20 to 50%, based on the weight of the composition on an anhydride basis. Preferred builders include inorganic phosphates and salts thereof, preferably orthophosphates, pyrophosphates, tripolyphosphates, alkali metal salts thereof and combinations thereof; Polycarboxylic acids and salts thereof, preferably citric acid, alkali metal salts thereof and combinations thereof; Aluminosilicates, salts thereof and combinations thereof, preferably amorphous aluminosilicates, crystalline aluminosilicates, mixed amorphous / crystalline aluminosilicates, alkali metal salts thereof and combinations thereof, most preferably zeolite A, zeolites P, zeolite MAP, salts thereof, and combinations thereof; Silicates such as layered silicates, salts thereof and combinations thereof, preferably layered sodium silicate and combinations thereof.

Preferred auxiliary components are bleaches. Preferably the detergent composition contains one or more bleaches. Typically, the composition contains one or more bleaches, from 1 to 50% by weight of the composition. Preferred bleaches are selected from the group consisting of peroxide sources, peracid sources, bleach promoters, bleach catalysts, photobleaches and combinations thereof. Preferred peroxide sources are selected from the group consisting of perborate monohydrate, perborate tetrahydrate, percarbonate, salts thereof, and combinations thereof. Preferred peracid sources are typically selected from the group consisting of peroxide sources such as bleach activators comprising perborate or percarbonate, preformed peracids and combinations thereof. Preferred bleach activators are selected from the group consisting of oxy-benzene-sulfonate bleach activators, lactam bleach activators, imide bleach activators and combinations thereof. Preferred sources of peracid are tetra-acetyl ethylene diamine (TAED) and peroxide sources such as percarbonate. Preferred oxy-benzene-sulfonate bleach activators are selected from the group consisting of nonanoyl-oxy-benzene-sulfonate, 6-nonamido-caproyl-oxy-benzene-sulfonate, salts thereof and combinations thereof. Preferred lactam-based bleach activators are acyl-caprolactam and / or acyl-valerolactam. Preferred imide-based bleach activators are N-nonanoyl-N-methyl-acetamide.

Preferred preformed peracids are selected from the group consisting of N, N-phthaloyl-amino-peroxycapronic acid, nonyl-amido-peroxyadipic acid, salts thereof and combinations thereof. Preferably, the STW-composition contains one or more peroxide sources and one or more peracid sources. Preferred bleach catalysts comprise one or more transition metal ions. Another preferred bleach is diacyl peroxide. Preferred bleach promoters are selected from the group consisting of zwitterionic imines, anionic imine multi-ions, quaternary oxaziridinium salts and combinations thereof. Highly preferred bleach promoters are selected from the group consisting of arylimium zwitterions, arylimium multi-ions and combinations thereof. Suitable bleach promoters are disclosed in US Patent No. 360,568, US Patent No. 5,360,569, and US Patent No. 5,370,826.

Preferred auxiliary components are re-deposition inhibitors. Preferably, the detergent composition contains one or more antideposition agents. Preferred antideposition agents include cellulose polymer components, most preferably carboxymethyl cellulose.

Preferred auxiliary components are chelating agents. Preferably the detergent composition contains one or more chelating agents. Preferably the detergent composition contains a chelating agent, based on the weight of the composition, of 0.01 to 10%. Preferred chelating agents are hydroxyethane-dimethylene-phosphonic acid, ethylene diamine tetra (methylene phosphonic) acid, diethylene triamine penacetate, ethylene diamine tetraacetate, diethylene triamine penta (methyl phosphonic) acid, ethylene Diamine disuccinic acid and combinations thereof.

Preferred adjunct ingredients are ear salt inhibitors. Preferably, the detergent composition contains one or more otitis inhibitors. Typically, the dye salt inhibitor is a polymeric component that retains the dye molecules by trapping the dye molecules and suspending them in the wash liquor. Preferred disinfection inhibitors are selected from the group consisting of polyvinylpyrrolidone, polyvinylpyridine N-oxides, polyvinylpyrrolidone-polyvinylimidazole copolymers and combinations thereof.

Preferred accessory ingredients include other enzymes. Preferably, the detergent composition contains one or more additional enzymes. Preferred enzymes are amylase, arabinosidase, carbohydrase, cellulase, chondroitinase, cutinase, dextranase, esterase, β-glucanase, gluco-amylase, hyaluronidase, Keratanase, laccase, ligninase, lipoxygenase, malanase, mannase, oxidase, pectinase, pentosanase, peroxidase, phenol oxidase, phospholipase, protease, pullulanase, Reductase, tanase, transferase, xylanase, xyloglucanase, and combinations thereof. Preferred additional enzymes are selected from the group consisting of amylases, carbohydrases, cellulases, proteases and combinations thereof.

Preferred auxiliary components are fabric preservatives. Preferably the detergent composition contains one or more fabric preservatives. Typically, fabric preservatives are polymeric ingredients that are deposited on the fabric surface to prevent fabric damage during the laundry process. Preferred fabric preservatives are cellulose that is hydrophobically modified. These hydrophobically modified celluloses reduce fabric wear, improve fiber-fiber interactions and reduce the loss of dyes from the fabric. Preferred hydrophobically modified celluloses are disclosed in WO 99/14245. Other preferred fabric preservatives are polymer components and / or oligomer components obtainable, preferably obtained by a process comprising the condensation step of imidazole and epichlorohydrin.

Preferred auxiliary components are salts. Preferably the detergent composition contains one or more salts. Salts can act as alkaline granting agents, buffers, builders, co-builders, deposition inhibitors, fillers, pH adjusters, stabilizers and combinations thereof. Typically, the present detergent composition contains 5 to 60% of the salt, based on the weight of the composition. Preferred salts are alkali metal salts of aluminates, carbonates, chlorides, bicarbonates, nitrates, phosphates, silicates, sulfates and combinations thereof. Other preferred salts are aluminates, carbonates, chlorides, bicarbonates, nitrates, phosphates, silicates, sulfates and alkaline earth metal salts thereof. Particularly preferred salts are sodium sulfate, sodium carbonate, sodium bicarbonate, sodium silicate, sodium sulfate and combinations thereof. Optionally, the alkali metal salts and / or alkaline earth metal salts may be anhydrides.

Preferred auxiliary components are antifouling agents. Preferably the detergent composition contains one or more antifouling agents. Typically, antifouling agents are polymeric compounds that modify the fabric surface to prevent redeposition of contaminants on the fabric. Preferred antifouling agents are copolymers comprising at least one terephthalate unit, preferably block copolymers. Preferred antifouling agents are copolymers synthesized from dimethylterephthalate, 1,2-propyl glycol and methyl capped polyethyleneglycol. Another preferred antifouling agent is anionic end capped polyester.

Preferred auxiliary components are contaminant suspensions. Preferably the detergent composition contains one or more contaminant suspending agents. Preferred contaminant suspending agents are polymeric polycarboxylates. Especially preferred are polymers derived from acrylic acid, polymers derived from maleic acid, and copolymers derived from maleic acid and acrylic acid. In addition to its contaminant suspension properties, polymeric polycarboxylates are also useful co-builders for laundry detergents. Other preferred contaminant suspending agents are alkoxylated polyalkylene imines. Particularly preferred alkoxylated polyalkylene imines are ethoxylated polyethylene imines or ethoxylated-propoxylated polyethylene imines. Other preferred contaminant suspending agents include the formula bis ((C ₂ H ₅ O) (C ₂ H ₄ O) _n (CH ₃ ) -N ⁺ -C _x H _2x -N ⁺ -(CH ₃ ) -bis ((C ₂ H ₄ O) _n (C ₂ H ₅ O)), wherein n is from 10 to 50 and x is from 1 to 20. Optionally, the contaminant suspension represented by the above formula is sulfated and / or Sulfonated.

Flexible system

The detergent composition of the present invention may also contain a softening agent for softening through washing, for example clay, optionally together with a flocculant and an enzyme.

Further more detailed descriptions of suitable detergent components can be found in WO 97/11151.

Washing method

The invention also includes a method of cleaning a fabric comprising the steps of cleaning, treating and / or masking the odor of the surface or fabric. Such methods include contacting this location, for example a fabric, with an aqueous solution comprising the detergent composition of the present invention. The present invention may be particularly advantageous at low water temperatures, for example, below 30 ° C, below 25 ° C or below 20 ° C. Typically, the aqueous wash will comprise at least 100 ppm or at least 500 ppm of detergent composition.

Example  1: fragrance composition

Example  2 Example  Perfume made from the composition of 1

The perfume component of the encapsulation and detergent composition below is a perfume according to the present invention and / or Examples 1 and 2.

Preparation of Perfume Particles Encapsulated with Modified Starch

Example 3

1. Add 225 g of capsul modified starch (National Starch & Chemical) to 450 g of water at 24 ° C.

2. In a turbine impeller with a diameter of 2 in., The mixture is stirred at 600 rpm for 20 minutes.

3. Add 75 g of fragrance oil near the vortex of the starch solution.

4. The resulting emulsion is stirred at 600 rpm for an additional 20 minutes.

5. Upon attaining a fragrance droplet size of less than 15 μm, the emulsion is pumped into a spray drying tower and sprayed through the spinning disc using a co-current airflow for drying. The inlet air temperature is set to 205 to 210 ° C and the outlet air temperature is stabilized at 98 to 103 ° C.

6. Collect dried particles of starch encapsulated fragrance at the dryer outlet.

Analysis of the finished fragrance particles (all percentages are by weight):

Total fragrance oil 24.56%

Encapsulated Oil / Free Oil or Surface Oil 24.46% / 0.10%

Starch 72.57%

2.87% moisture

Particle size distribution

16% less than 50㎛

50 to 500 μm 83%

More than 500㎛ 1%

Example 4

In a suitable container 500 g of HiCap 100 modified starch (supplied by National Starch and Chemical) is dissolved in 1000 g of deionized water. Once a homogeneous solution is achieved, 40 g of citric anhydride is added to the starch solution. The mixture is stirred for 10 minutes to dissolve citric acid. At this point, 600 g of fragrance is added to the mixture. The emulsion is then stirred for an additional 10 minutes using a high shear force mixer (ARD-Barico).

The mixture is then spray dried in a Production Minor cocurrent spray dryer manufactured by Niro A / S. We also use rotary atomizing disc type FS 1 from Niro A / S. The air inlet temperature is 200 ° C and the outlet temperature is 90 ° C. The disk speed is set at 28,500 rpm. The tower is sprayed with water for 30 minutes prior to spray drying of the emulsion to stabilize at this condition. The dried particles are collected in a cyclone.

Detergent compositions containing the encapsulated fragrances of Examples 3 and 4 are illustrated in Table 3.

Claims (10)

At least 90% identity with wild-type lipases derived from Humicola lanuginosa strain DSM 4109 (a) and electrically neutral at the surface of the three-dimensional structure within 15 E of E1 or Q249 compared to wild-type lipases (B) comprises a peptide adduct at the C-terminus, (c) includes a peptide adduct at the N-terminus, and / or comprises a substitution of a negatively charged amino acid with a positively charged amino acid; d) a negative amino acid at position E210 of wild-type lipase, (i) a negatively charged amino acid in a region corresponding to positions 90-101 of wild-type lipase, and (ii) a position corresponding to N94 of wild-type lipase Have a net charge that is either neutral or negative in the region corresponding to a neutral or negative amino acid and / or in a region corresponding to positions 90-101 of the wild type lipase (iii) Is (e), the lipase polypeptide having the amino acid sequence (1) and A detergent comprising at least one water soluble hydroxyl compound, preferably encapsulated fragrance particles (2) comprising at least partially water soluble solid matrix (a) comprising starch and fragrance oil (b) encapsulated by the solid matrix. Composition. The method of claim 1, wherein the encapsulated fragrance oil has at least 1% by weight of at least one fragrance component having a boiling point of 260 ° C. or less at 36 KN / m 2 (760 mmHg) and a log ₁₀ (ClogP) calculated value of octanol / water coefficient P of at least 3.0, 5 wt% or more, 10 wt% or 40 wt% or more of the detergent composition. 3. The detergent composition of claim 1 or 2, wherein the encapsulated fragrance oil comprises an ester derived from a fatty acid having 1 to 7 carbon atoms. The detergent composition according to claim 1, wherein in addition to the encapsulated fragrance oil, an additional fragrance oil is present as a sprayed-on component. 5. The detergent composition of claim 4, wherein the fragrance oil comprises esters derived from fatty acids having 1 to 7 carbon atoms, wherein at least 90% by weight of the esters derived from fatty acids having 1 to 7 carbon atoms are present in the encapsulated perfume particles. The detergent composition according to claim 1, wherein the encapsulated fragrance particles comprise benzyl acetate and / or phenylethyl acetate. The detergent composition according to claim 1, wherein the fragrance oil in the encapsulated fragrance particles is absorbed or adsorbed to the carrier and both the fragrance oil and the carrier are encapsulated. 8. The detergent composition according to claim 1, wherein the fragrance oil in the encapsulated fragrance particles and any further fragrance oil in the detergent composition comprise a fragrance composition, The fragrance composition comprises at least 1%, at least 5% or at least 10% by weight of at least one fragrance component having a molecular weight greater than 0 Daltons and up to 350 Daltons, at least 80% of the at least fragrance components have a cLogP of at least 2.4 and the fragrance composition A detergent composition comprising at least 1% or at least 5% of at least one fragrance component of the cLogP 2.4 or more. A washing method comprising the step of washing a textile product in an aqueous solution comprising the detergent composition according to any one of claims 1 to 8. The method of claim 9, wherein the temperature of the aqueous solution is less than 30 ℃.