KR20070082928A - Apparatus and method for analyzing blood components using correction of energy absorption state - Google Patents

Apparatus and method for analyzing blood components using correction of energy absorption state Download PDF

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KR20070082928A
KR20070082928A KR1020060015985A KR20060015985A KR20070082928A KR 20070082928 A KR20070082928 A KR 20070082928A KR 1020060015985 A KR1020060015985 A KR 1020060015985A KR 20060015985 A KR20060015985 A KR 20060015985A KR 20070082928 A KR20070082928 A KR 20070082928A
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blood vessel
blood
energy absorption
scattering coefficient
correction
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KR101047968B1 (en
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민위식
김성욱
김용석
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(주)하모닉스
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    • E—FIXED CONSTRUCTIONS
    • E04—BUILDING
    • E04F—FINISHING WORK ON BUILDINGS, e.g. STAIRS, FLOORS
    • E04F11/00—Stairways, ramps, or like structures; Balustrades; Handrails
    • E04F11/18—Balustrades; Handrails
    • E04F11/181—Balustrades
    • E04F11/1851—Filling panels, e.g. concrete, sheet metal panels
    • E04F11/1853—Glass panels
    • E—FIXED CONSTRUCTIONS
    • E04—BUILDING
    • E04F—FINISHING WORK ON BUILDINGS, e.g. STAIRS, FLOORS
    • E04F11/00—Stairways, ramps, or like structures; Balustrades; Handrails
    • E04F11/18—Balustrades; Handrails
    • E04F11/181—Balustrades
    • E04F11/1812—Details of anchoring to the wall or floor
    • E—FIXED CONSTRUCTIONS
    • E06—DOORS, WINDOWS, SHUTTERS, OR ROLLER BLINDS IN GENERAL; LADDERS
    • E06B—FIXED OR MOVABLE CLOSURES FOR OPENINGS IN BUILDINGS, VEHICLES, FENCES OR LIKE ENCLOSURES IN GENERAL, e.g. DOORS, WINDOWS, BLINDS, GATES
    • E06B5/00—Doors, windows, or like closures for special purposes; Border constructions therefor
    • E06B5/10—Doors, windows, or like closures for special purposes; Border constructions therefor for protection against air-raid or other war-like action; for other protective purposes
    • E06B5/106—Frames for bullet-proof windows
    • E—FIXED CONSTRUCTIONS
    • E06—DOORS, WINDOWS, SHUTTERS, OR ROLLER BLINDS IN GENERAL; LADDERS
    • E06B—FIXED OR MOVABLE CLOSURES FOR OPENINGS IN BUILDINGS, VEHICLES, FENCES OR LIKE ENCLOSURES IN GENERAL, e.g. DOORS, WINDOWS, BLINDS, GATES
    • E06B5/00—Doors, windows, or like closures for special purposes; Border constructions therefor
    • E06B5/10—Doors, windows, or like closures for special purposes; Border constructions therefor for protection against air-raid or other war-like action; for other protective purposes
    • E06B5/16—Fireproof doors or similar closures; Adaptations of fixed constructions therefor
    • E—FIXED CONSTRUCTIONS
    • E06—DOORS, WINDOWS, SHUTTERS, OR ROLLER BLINDS IN GENERAL; LADDERS
    • E06B—FIXED OR MOVABLE CLOSURES FOR OPENINGS IN BUILDINGS, VEHICLES, FENCES OR LIKE ENCLOSURES IN GENERAL, e.g. DOORS, WINDOWS, BLINDS, GATES
    • E06B7/00—Special arrangements or measures in connection with doors or windows
    • E06B7/14—Measures for draining-off condensed water or water leaking-in frame members for draining off condensation water, throats at the bottom of a sash

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Abstract

An apparatus and method for analyzing blood components by using correction of energy absorption state are provided to improve accuracy of non-invasive blood components analysis by minimizing effects of skin tissues around the blood vessel. The apparatus for analyzing blood components by using correction of energy absorption state comprises a probe for investigating an electromagnetic wave by moving around the blood vessel, and an analysis portion for extracting the width of blood vessel by generating the phase difference of a permeation coefficient, extracting diffusion coefficients of the skin tissue and blood vessel, calculating a determination error by comparing the predicted total diffusion coefficient value with the determined total diffusion coefficient value, correcting the predicted value to minimize the error, and determining dielectric constant and energy absorption state of the blood vessel.

Description

에너지 흡수도 보정을 이용한 혈액 성분 분석 장치 및 방법{Apparatus and method for analyzing blood components using correction of energy absorption state}Apparatus and method for analyzing blood components using correction of energy absorption state}

도 1은 본 발명에 따른 혈액 성분 분석 장치의 프로브의 이동, 및 그에 따른 투과 계수의 위상 변화를 도시한 도면.1 is a view showing the movement of the probe of the blood component analysis apparatus according to the present invention, and the phase change of the transmission coefficient accordingly.

도 2는 도 1 중 프로브의 위치에 따른 투과 계수를 도시한 도면.2 is a diagram illustrating a transmission coefficient according to a position of a probe in FIG. 1.

도 3은 도 1의 프로브 스캐닝 과정을 상세히 도시한 도면.3 is a diagram illustrating the probe scanning process of FIG. 1 in detail;

도 4는 도 3의 스캐닝 과정에 따른 투과 계수의 위상 변화를 도시한 도면.4 is a view illustrating a phase change of a transmission coefficient according to the scanning process of FIG. 3.

도 5는 프로브가 혈관 상에 위치한 일 예를 도시한 도면.5 shows an example where a probe is located on a vessel;

도 6 및 7은 수직면 피부 보상을 설명하기 위한 도면.6 and 7 illustrate vertical skin compensation.

도 8은 본 발명에 따른 혈액 성분 분석 방법에 따른 측정법의 흐름도.8 is a flow chart of the measurement method according to the blood component analysis method according to the present invention.

본 발명은 혈액 분석 장치 및 방법에 관한 것으로서, 더욱 상세하게는 비침습 혈액 분석 장치 및 방법에 관한 것이다.The present invention relates to a blood analysis device and method, and more particularly to a non-invasive blood analysis device and method.

일반적으로 건강 검진을 수행할 때, 혈액 성분 검사는 반드시 수행된다. 그 이유는 혈액 성분은 건강 검진 대상자의 건강 상태를 파악할 수 있도록 하는 중요한 인자이기 때문이다.In general, when performing a physical examination, a blood component test is necessarily performed. The reason for this is that blood components are an important factor in determining the health status of the subject.

통상 혈액의 검사는 주사기로 혈관 내의 혈액을 채취하는 방식으로 수행되지만, 이러한 방식은 불편할 뿐만 아니라 주사기 사용으로 인한 감염 우려나 혈액 채취 시 수반되는 고통으로 인해 검사 대상자들에게 의해 꺼려지고 있으며, 이로 인해 건강 검진 자체까지 회피하는 경우가 발생하고 있다.Usually, the blood test is performed by collecting blood in a blood vessel with a syringe, but this method is not only inconvenient but also reluctant by test subjects because of the concern about the infection caused by the use of the syringe or the pain associated with the blood collection. There are cases where even health checks are avoided.

이러한 문제점을 해결하기 위해, 최근, 혈액을 채취하지 않고서도 혈액의 성분을 분석할 수 있는 방법이 개발되고 있으며, 이러한 방법의 하나로서, 외부에서 전자기파를 혈관에 조사하고, 조사된 전자기파에 대한 혈액의 에너지 흡수도를 파악하는 방식으로 혈액의 성분을 분석하는 방법이 사용되고 있다. In order to solve this problem, a method for analyzing blood components without blood collection has recently been developed. As one of these methods, external electromagnetic waves are irradiated to blood vessels and blood for the irradiated electromagnetic waves is developed. The method of analyzing the components of the blood is used to determine the energy absorption of the.

그러나 이러한 방법의 사용에 있어서, 외부에서 전자기파를 조사하기 때문에 분석 결과에는 혈관 주변의 피부 조직에 의한 영향이 포함되어 정확한 측정 결과를 얻을 수 없는 문제점이 있다.However, in the use of such a method, since the electromagnetic wave is irradiated from the outside, the analysis result includes the influence of the skin tissue around the blood vessel, and thus there is a problem that an accurate measurement result cannot be obtained.

본 발명은 상술한 종래의 문제점을 해결하기 위해 안출된 것으로서, 혈관 주변 피부 조직에 의한 영향을 최소화할 수 있는 혈액 성분 분석 장치 및 방법을 제공하는 것을 목적으로 한다.The present invention has been made to solve the above-mentioned conventional problems, and an object of the present invention is to provide an apparatus and method for analyzing blood components that can minimize the influence of skin tissue around blood vessels.

상기 문제점을 해결하기 위해 본 발명에 따른 에너지 흡수도 보정을 이용한 혈액 분석 장치는 프로브, 및 분석부를 포함한다. 프로브는 혈관 주변으로 이동하 여 전자기파를 조사한다.In order to solve the above problems, the blood analysis apparatus using the energy absorption correction according to the present invention includes a probe and an analysis unit. The probe moves around the blood vessel to irradiate electromagnetic waves.

분석부는 투과 계수의 위상차 발생에 의해 혈관의 폭을 추출하고, 피부 조직의 산란 계수와 혈관의 산란 계수를 추출하고, 소정의 예측 전체 산란 계수치와 측정 전체 산란 계수치를 비교하여 측정 오차를 산출하고, 오차가 최소화되기 위한 예측치를 보정하며, 혈관의 유전율 상수 및 에너지 흡수도를 측정한다.The analysis unit extracts the width of the blood vessel by the phase difference generation of the transmission coefficient, extracts the scattering coefficient of the skin tissue and the scattering coefficient of the blood vessel, calculates a measurement error by comparing a predetermined predicted total scattering coefficient value and the measured total scattering coefficient value, Correct the estimate to minimize the error and measure the permittivity and energy absorption of the vessel.

아울러, 상기 장치 발명의 방법 형태의 발명이 함께 청구된다.Furthermore, invention of the method form of the said device invention is claimed together.

피부 속 혈관의 혈액의 유전율 및 에너지 흡수도를 측정하기 위해서는 혈관 주변의 피부 조직에 의한 영향을 보정하여야 한다.In order to measure the permittivity and energy absorption of blood in blood vessels in the skin, the effects of skin tissue around blood vessels should be corrected.

이를 위해서는 코플래너(Coplanar) 형태의 웨이브 가이드 라인(waveguide line)을 이용하여 프로브(Probe)를 이동시키면 이동 거리에 따른 투과 위상 변화가 발생하며 투과 위상의 차이를 통해서 전체 프로브의 길이에 대한 피부 조직의 길이와 혈관의 폭과 이를 이용하여 피부 조직의 산란계수와 혈관의 산란 계수를 추출할 수 있으며, 피부 조직과 혈관을 포함한 산란 계수로 재조합하여 실제 측정치와 비교하여 측정 오차를 구하며 이를 반복적으로 행하여 측정 오차를 최소화할 수 있다.To do this, when the probe is moved using a coplanar waveguide line, the transmission phase changes according to the moving distance, and the skin tissue with respect to the length of the entire probe through the difference in the transmission phase. Using the length and width of the blood vessel and the scattering coefficient of the skin tissue and the scattering coefficient of the blood vessel can be extracted, and recombined with the scattering coefficient including the skin tissue and blood vessel, the measurement error is calculated by comparing with the actual measurement value and repeatedly The measurement error can be minimized.

이러한 과정을 통해 혈관 내 혈액의 유전율 및 에너지 흡수도를 측정함에 있어 개인간 피부 조직의 상이성을 위한 측정 오차를 보정할 수 있다.Through this process, in measuring the permittivity and energy absorption of blood in blood vessels, it is possible to correct measurement errors for differences in skin tissue between individuals.

이하, 첨부된 도면을 참조하여 본 발명의 바람직한 실시예를 설명한다.Hereinafter, exemplary embodiments of the present invention will be described with reference to the accompanying drawings.

도 1은 본 발명에 따른 혈액 성분 분석 장치의 프로브의 이동, 및 그에 따른 투과 계수의 위상 변화를 도시한 도면이다. 도 1의 좌측에는 혈관 위를 지나가는 프로브의 이동이 도시되어 있고, 좌측에는 그에 따른 투과 계수의 위상 변화가 도시되어 있다.1 is a view showing the movement of the probe of the blood component analysis apparatus according to the present invention, and the phase change of the transmission coefficient accordingly. The left side of FIG. 1 shows the movement of the probe across the vessel and the left side shows the phase change of the transmission coefficient accordingly.

도 2는 도 1 중 프로브의 위치에 따른 투과 계수를 도시한 도면이다. 도 2에서 프로브가 혈관 위에 위치할 때와 위치하지 않을 때의 투과 계수가 도시되어 있다.FIG. 2 is a diagram illustrating a transmission coefficient according to a position of a probe in FIG. 1. In Figure 2 the permeation coefficients are shown with and without probes positioned on the vessel.

도 3은 도 1의 프로브 스캐닝 과정을 상세히 도시한 도면이고, 도 4는 도 3의 스캐닝 과정에 따른 투과 계수의 위상 변화를 도시한 도면이다. 투과 계수의 위상을 산출하는 식은 다음과 같다.3 is a diagram illustrating the probe scanning process of FIG. 1 in detail, and FIG. 4 is a diagram illustrating a phase change of a transmission coefficient according to the scanning process of FIG. 3. The equation for calculating the phase of the transmission coefficient is as follows.

Figure 112006012064902-PAT00001
Figure 112006012064902-PAT00001

Figure 112006012064902-PAT00002
Figure 112006012064902-PAT00002

피부의 산란 계수를 알기 위한 수식들은 다음과 같다.The formulas for knowing the scattering coefficient of the skin are as follows.

도 5는 프로브가 혈관 상에 위치한 일 예를 도시한 도면이다. 5 is a diagram illustrating an example in which a probe is positioned on a blood vessel.

Sample Misplacement (Probe right Scanning)Sample Misplacement (Probe right Scanning)

Figure 112006012064902-PAT00003
Figure 112006012064902-PAT00003

Figure 112006012064902-PAT00004
Figure 112006012064902-PAT00004

Misplacement -> Skin[S]Misplacement-> Skin [S]

Figure 112006012064902-PAT00005
Figure 112006012064902-PAT00005

Skin S-ParameterSkin S-Parameter

Figure 112006012064902-PAT00006
Figure 112006012064902-PAT00006

혈관의 산란 계수를 알기 위한 수식들은 다음과 같다.The equations for knowing the scattering coefficient of blood vessels are as follows.

Blood S-ParameterBlood S-Parameter

Figure 112006012064902-PAT00007
Figure 112006012064902-PAT00007

Phase DifferencePhase difference

Figure 112006012064902-PAT00008
Figure 112006012064902-PAT00008

Figure 112006012064902-PAT00009
Figure 112006012064902-PAT00009

Attenuation DifferenceAttenuation Difference

Figure 112006012064902-PAT00010
Figure 112006012064902-PAT00010

Blood Dielectric ConstantBlood dielectric electric

Figure 112006012064902-PAT00011
Figure 112006012064902-PAT00011

수직면 피부 보상을 위한 계산 수식들은 다음과 같다. 도 6 및 7은 수직면 피부 보상을 설명하기 위한 도면이다.Calculation formulas for vertical skin compensation are as follows. 6 and 7 illustrate vertical skin compensation.

Vertical ErrorVertical Error

Figure 112006012064902-PAT00012
Figure 112006012064902-PAT00012

Vertical error CorrectionVertical error correction

Figure 112006012064902-PAT00013
Figure 112006012064902-PAT00013

Figure 112006012064902-PAT00014
Figure 112006012064902-PAT00014

피부와 혈관을 전체 산란 계수로 계산하기 위한 수식들은 다음과 같다.The formulas for calculating skin and blood vessels as total scattering coefficients are as follows.

Chain T-ParameterChain T-Parameter

Figure 112006012064902-PAT00015
Figure 112006012064902-PAT00015

Chain T -> S ParameterChain T-> S Parameter

Figure 112006012064902-PAT00016
Figure 112006012064902-PAT00016

도 8은 본 발명에 따른 혈액 성분 분석 방법에 따른 측정법의 흐름도이다.8 is a flow chart of the measurement method according to the blood component analysis method according to the present invention.

먼저,

Figure 112006012064902-PAT00017
를 구하고, 각각의 S 파라미터로부터
Figure 112006012064902-PAT00018
를 구한다. first,
Figure 112006012064902-PAT00017
Is obtained from each S parameter
Figure 112006012064902-PAT00018
Obtain

다음으로,

Figure 112006012064902-PAT00019
인 지점에서의 LS, LB를 구하고,
Figure 112006012064902-PAT00020
,
Figure 112006012064902-PAT00021
,
Figure 112006012064902-PAT00022
를 구한다.to the next,
Figure 112006012064902-PAT00019
Find L S , L B at the point of,
Figure 112006012064902-PAT00020
,
Figure 112006012064902-PAT00021
,
Figure 112006012064902-PAT00022
Obtain

마지막으로,

Figure 112006012064902-PAT00023
를 구한다.Finally,
Figure 112006012064902-PAT00023
Obtain

본 발명에 의해 혈관 주변 피부 조직에 의한 영향을 최소화하면서도 더욱 정확하게 비침습 혈액 성분 분석을 수행할 수 있게 된다. The present invention enables more accurate non-invasive blood component analysis while minimizing the effects of skin tissue around blood vessels.

본 발명이 비록 일부 실시예에 의해 설명되었지만 본 발명의 범위는 이에 의해 제한되어서는 아니 되고, 특허청구범위에 의해 뒷받침되는 상기 실시예의 변형이나 개량에도 미쳐야 할 것이다.Although the invention has been described in terms of some embodiments, the scope of the invention should not be limited thereby, but should be constrained by modifications or improvements of the embodiments supported by the claims.

Claims (2)

혈관 주변으로 이동하여 전자기파를 조사하는 프로브; 및A probe moving around the blood vessel to irradiate electromagnetic waves; And 투과 계수의 위상차 발생에 의해 혈관의 폭을 추출하고, 피부 조직의 산란 계수와 혈관의 산란 계수를 추출하고, 소정의 예측 전체 산란 계수치와 측정 전체 산란 계수치를 비교하여 측정 오차를 산출하고, 오차가 최소화되기 위한 예측치를 보정하며, 혈관의 유전율 상수 및 에너지 흡수도를 측정하는 분석부를 포함하는 것을 특징으로 하는 에너지 흡수도 보정을 이용한 혈액 성분 분석 장치.The width of the blood vessel is extracted by the phase difference of the transmission coefficient, the scattering coefficient of the skin tissue and the scattering coefficient of the blood vessel are extracted, and the measurement error is calculated by comparing the predetermined predicted total scattering coefficient value with the measured total scattering coefficient value. Blood component analysis device using the energy absorption correction, characterized in that for correcting the prediction value to be minimized, including an analysis unit for measuring the dielectric constant and energy absorption of the blood vessel. 혈관 주변으로 프로브를 이동하여 전자기파를 조사하는 단계; Irradiating electromagnetic waves by moving the probe around the blood vessel; 투과 계수의 위상차 발생에 의해 혈관의 폭을 추출하는 단계;Extracting the width of the blood vessel by the phase difference generation of the transmission coefficient; 피부 조직의 산란 계수와 혈관의 산란 계수를 추출하는 단계;Extracting the scattering coefficient of skin tissue and the scattering coefficient of blood vessels; 소정의 예측 전체 산란 계수치와 측정 전체 산란 계수치를 비교하여 측정 오차를 산출하고, 오차가 최소화되기 위한 예측치를 보정하는 단계; 및Calculating a measurement error by comparing the predetermined predicted total scattering coefficient value and the measured total scattering coefficient value, and correcting the predicted value for minimizing the error; And 상기 혈관의 유전율 상수 및 에너지 흡수도를 측정하는 분석부를 포함하는 단계를 포함하는 것을 특징으로 하는 에너지 흡수도 보정을 이용한 혈액 성분 분석 방법.Blood component analysis method using the energy absorption correction, characterized in that it comprises a step of measuring the dielectric constant and energy absorption of the blood vessels.
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US10502683B2 (en) 2017-07-27 2019-12-10 Samsung Electronics Co., Ltd. Photodetector selection apparatus and method and scattering coefficient measurement apparatus and method

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