KR20070055855A

KR20070055855A - Dnp63a gene and screening methods of anticancer agent by using it

Info

Publication number: KR20070055855A
Application number: KR1020050114322A
Authority: KR
Inventors: 이현숙; 이정화
Original assignee: 재단법인서울대학교산학협력재단
Priority date: 2005-11-28
Filing date: 2005-11-28
Publication date: 2007-05-31
Also published as: KR100794219B1

Abstract

본 발명은 △Np63α을 코딩하는 유전자 및 이를 포함하는 항암제 스크리닝 방법에 관한 것으로서, 보다 구체적으로는 상피 세포 유래 암세포와 잠재적인 항암제의 접촉에 의해 핵에서 세포질로의 이동하는 △Np63α을 코딩하는 유전자, 단백질, 상기 유전자 및 리포터를 포함하는 재조합 벡터, 상기 벡터를 포함하는 암세포에 관한 것이며, 또한 암세포에 잠재적인 항암제의 접촉에 의해 △Np63α의 단백질이 핵에서 세포질로의 이동을 확인하는 것을 특징으로 하는 고효율의 항암제 스크리닝 방법에 관한 것이다.The present invention relates to a gene encoding ΔNp63α and an anticancer agent screening method comprising the same, and more particularly, a gene encoding ΔNp63α, which migrates from the nucleus to the cytoplasm by contact of an epithelial cell-derived cancer cell with a potential anticancer agent, The present invention relates to a protein, a recombinant vector comprising the gene and a reporter, and a cancer cell including the vector, wherein the protein of ΔNp63α confirms migration from the nucleus to the cytoplasm by contacting the cancer cell with a potential anticancer agent. It relates to a high-efficiency anticancer screening method.

△Np63α 유전자, 항암제, 스크리닝 방법ΔNp63α gene, anticancer agent, screening method

Description

DNp63a Gene And Screening Methods of Anticancer Agent By Using it}

도 1은 ME180 세포에 TNF-α 처리후 단백질 수준에서 DNp63a 의 양의 감소 및 MG132 처리후 분해억제되는 것을 보인다. TNF-a를 16시간 처리한 후 단백질 합성을 막는 억제제인 시클로헥사마이드(cychlohexamide; CHX)를 20ug/ml로 처리하여, 표지된 시간대 별로 채취 하여 단백질 상태에서의 안정성의 변화를 보았다. 그 결과 CHX를 처리한 후 4시간부터 분해가 되는 것을 보았고, 단백질 분해효소 저해제인 MG132(20nM)를 같이 처리했을 때는 4시간이후에도 분해가 되지 않고 안정되게유지되는 것을 보인다. FIG. 1 shows that ME180 cells show a decrease in the amount of DNp63a at the protein level after TNF-α treatment and degradation inhibition after MG132 treatment. After 16 hours of treatment with TNF-a, cyclohexamide (CHCH), an inhibitor of protein synthesis, was treated at 20 ug / ml and collected at labeled time periods to see changes in the stability of the protein. As a result, it was observed that from 4 hours after CHX treatment, and when MG132 (20nM), a protease inhibitor, was treated together, it was not decomposed even after 4 hours and maintained stable.

도 2 DNp63a 단백질이 TNF-α 처리후 핵에서 세포질로 이동되는 것을 보인다.2 DNp63a protein is shown to migrate from the nucleus to the cytoplasm after TNF-α treatment.

도 3은 본발명에 따른 DNp63a 및 리포터 유전자를 포함하는 재조합 발현 벡터의 개열지도이다.3 is a cleavage map of a recombinant expression vector comprising DNp63a and a reporter gene according to the present invention.

인간의 암의 80%가 상피세포유래의 암이며, 암이 줄기세포에서 유전자 변형으로 유래할 것이라는 생각에 근거, 특이적으로 줄기세포와 암세포에서만 발현되고, 분화시 발현이 억제된다고 알려진 △Np63α의 기능이 매우 중요시 될 수 있다. 또한 △Np63α가 세포의 증식과 사멸에서 p53의 기능을 억제하는 기능을 하고 있으며, 과발현시 암발생 조절 유전자로서의 기능을 하게 되어, 줄기세포에서의 p53와 △Np63α의 양적 균형이 세포의 증식과 분화를 조절할 것으로 생각된다. 따라서 △Np63α의 단백질 수준에서의 안정성 및 세포내에서의 위치가 암발생 유전자로서의 기능에 매우 중요하게 작용할 것이라 유추된다. 80% of human cancers are epithelial cell-derived cancers. Based on the idea that cancers may be derived from stem cells, they are specifically expressed in stem cells and cancer cells, and the expression of ΔNp63α is known to be inhibited during differentiation. Functionality can be very important. In addition, ΔNp63α has a function of inhibiting the function of p53 in the proliferation and death of cells, and functions as a gene for regulating cancer during overexpression. As a result, quantitative balance of p53 and ΔNp63α in stem cells promotes cell proliferation and differentiation. It is thought to control. Therefore, it is inferred that stability and protein position of ΔNp63α will play a very important role in functioning as a cancer gene.

핵단백질인 단백질 p63은 염색체 3q에 위치하고 있고, p53과 상동성을 가지고 있는 것으로 보인다. p53 단백질은 암발생억제 유전자로 세포 주기와 세포의 사멸의 조절에 중요한 다기능성의 DNA-결합 단백질을 가지고 있다. p63은 세가지의 아이소폼으로 존재한다. 각각은 두개의 선택적인 프로모터에 의해서 두 그룹의 전사체를 만든다. 첫 번째는 p53과 같이 N-말단 전사 활성 도메인을 가지고 있는 전체 길이의 단백질을 암호화 하고 있다. 이것은 세포사멸을 일으킬 수 있다. 두 번째는 트렁케이트된 단백질을 암호화 하고 있고, N-말단 전사활성 도메인이 없다(△Np63). △Np63은 우성의 네가티브한 방식으로 p53에 의한 그리고/또는 전체 길이의 p63 전사활성을 억제한다. Nuclear protein p63 is located on chromosome 3q and appears to have homology with p53. p53 protein is a cancer suppressor gene that contains a multifunctional DNA-binding protein that is important for regulating cell cycle and cell death. p63 exists in three isoforms. Each produces two groups of transcripts by two selective promoters. The first encodes a full-length protein with an N-terminal transcriptional active domain, such as p53. This can cause cell death. The second encodes a truncated protein and lacks the N-terminal transcriptional activity domain (ΔNp63). ΔNp63 inhibits p53 transcriptional activity by and / or full length of p53 in a dominant negative manner.

미국특허출원 US20020094547A1(발명의 명칭: Differential diagnosis of cancer and other conditions based on expression of p63) 발명은 p63의 유전자 산물, 이 유전자를 포함하는 핵산, mRNA 그리고 이 유전자를 포함하는 cDNA에 관한 것이고, 이 유전자 및 이 유전자의 산물을 암같은 어떤 질병의 치료 또는 진단에 사용하는 것에 관한 것이다. 이 발명은 이와 같은 진단 및 치료 방법이 사용되어지는 키트에 관한 것이다. 상기 미국특허출원에서는 분화되어진 폐암세포와 비분화된 폐암세포에서 p63의 유전자 또는 단백질을 측정함으로써 구별할 수 있는 방법이 제안되었다. p63이 없는 것은 비분화된 폐암 세포인 것을 나타낸다고 제시하고 있다.US patent application US20020094547A1 (differential diagnosis of cancer and other conditions based on expression of p63) The invention relates to a gene product of p63, a nucleic acid comprising this gene, mRNA and a cDNA comprising the gene. And the use of products of this gene in the treatment or diagnosis of certain diseases such as cancer. The present invention relates to kits in which such diagnostic and therapeutic methods are used. In the US patent application, a method that can be distinguished by measuring a gene or protein of p63 in differentiated lung cancer cells and undifferentiated lung cancer cells has been proposed. The absence of p63 suggests that it is an undifferentiated lung cancer cell.

국제특허출원 WO04048520A2(발명의 명칭: REDD1, A Transcriptional Target of p63 and p53, and method of use therefor)에서는 REDD1이라는 p53-의존적인 DNA 손상 반응과 p63 매개 상피세포의 분화의 조절과 관련되어있는 공통 전사 타켓에 대하여 기술하고 있다.International patent application WO04048520A2 (name of invention REDD1, A Transcriptional Target of p63 and p53, and method of use therefor) has a common transcription associated with the p53-dependent DNA damage response called REDD1 and the regulation of differentiation of p63 mediated epithelial cells. It describes the target.

유럽 특허출원 EA0003326B1 (발명의 명칭: Methods of cancer treating)에서는 인간의 암을 치료하기 위한 방법으로 유기의 비단백 화합물을 p53 패밀리의 인간 단백질에 접촉시킨 후 안정화시키고, 상기 안정화된 단백질을 상기 단백질의 야생형의 활동에 참여하는 하나 또는 그 이상의 단백질과 접촉시키는 것을 특징으로 하는 암치료 방법이 개시되어져 있다.European patent application EA0003326B1 (name of Methods of cancer treating) is a method for treating human cancer, in which organic nonprotein compounds are contacted with human proteins of the p53 family and then stabilized, and the stabilized proteins are Disclosed is a method for treating cancer characterized by contact with one or more proteins participating in wild-type activity.

미국 특허출원 US6479285(발명의 명칭: p53 as a regulator of cell differentiation)에서는 p53의 활성을 억제하는 방법이 제공되어지고 있으며 이들 조직을 분화에서 p53관련 블록을 극복할 수 있는 물질을 찾기위한 스크리닝 도구로 사용되어질 수 있다고 보고 하였다. 그러나 △Np63α의 생화학적인 성질과 세포내에서의 위치변화를 이용하여 항암제를 스크리닝 하는데 사용한 예가 없다. US patent application US6479285 (named p53 as a regulator of cell differentiation) provides a method for inhibiting the activity of p53 and screens these tissues as a screening tool for finding substances that can overcome p53-related blocks in differentiation. It can be used. However, there have been no examples of screening anticancer drugs using the biochemical properties of ΔNp63α and its position in cells.

본 발명자들은 △Np63α의 단백질이 분해되어 질 때 핵에서 세포질로 이동되어지는 것을 발견하고 본 발명을 완성하였다. The present inventors found that the protein of ΔNp63α is transported from the nucleus to the cytoplasm when the protein is degraded, thus completing the present invention.

상피 세포암의 특이적 성장 인자인 △Np63α의 특성을 이용하여 단시간내에 효과적으로 항암제를 스크리닝 할 수 있는 시스템 개발하는 것이다.By developing the characteristics of ΔNp63α, a specific growth factor for epithelial cell carcinoma, a system for effectively screening anticancer drugs can be developed in a short time.

본 발명은 상피 세포 유래 암세포에서 잠재적인 항암제의 접촉에 의해 핵에서 세포질로 이동하는 △Np63α을 코딩하는 유전자에 관한 것이다.The present invention relates to a gene encoding ΔNp63α that migrates from the nucleus to the cytoplasm by contact with a potential anticancer agent in epithelial cell derived cancer cells.

본 발명은 상피 세포 유래 암세포에서 잠재적인 항암제의 접촉에 의해 핵에서 세포질로 이동하는 △Np63α 단백질에 관한 것이다.The present invention relates to a ΔNp63α protein that migrates from the nucleus to the cytoplasm by contact of a potential anticancer agent in epithelial cell derived cancer cells.

본 발명은 상피 세포 유래 암세포에서 잠재적인 항암제의 투여에 의해 핵에서 세포질로 이동하는 △Np63α 유전자와 이 유전자를 확인하기 위한 리포터 유전자를 포함하는 재조합 벡터에 관한 것이다.The present invention relates to a recombinant vector comprising a ΔNp63α gene that migrates from the nucleus to the cytoplasm by administration of a potential anticancer agent in epithelial cell-derived cancer cells and a reporter gene for identifying the gene.

본 발명은 상기 재조합 벡터로 형질전환된 상피 세포 유래 암세포에 관한 것이다.The present invention relates to epithelial cell-derived cancer cells transformed with the recombinant vector.

본 발명은 상피 세포 유래 암세포에서 잠재적인 항암제의 투여에 의해 △Np63α의 단백질이 핵에서 세포질로의 이동을 확인하는 것을 특징으로 하는 항암제 스크리닝 방법에 관한 것이다.The present invention relates to a method for screening an anticancer agent, wherein the ΔNp63α protein moves from the nucleus to the cytoplasm by administration of a potential anticancer agent in epithelial cell-derived cancer cells.

본 발명은 상기 암세포가 △Np63α 유전자와 이를 확인할 수 있는 리포터 유전자를 포함하는 재조합 벡터로 형질전환 되어진 것을 특징으로 하는 항암제 스크리닝 방법에 관한 것이다.The present invention relates to an anticancer drug screening method, wherein the cancer cells are transformed with a recombinant vector comprising a ΔNp63α gene and a reporter gene capable of identifying the same.

본 발명은 △Np63α 유전자와 이를 확인할 수 있는 리포터 유전자를 벡터에 클로닝시키는 단계;The present invention comprises cloning a ΔNp63α gene and a reporter gene capable of identifying the same into a vector;

상기 클론된 벡터를 상피 세포 유래 암세포에 형질전환하여 일정시간 발현시키는 단계;Transforming the cloned vector into epithelial cell-derived cancer cells and expressing the cloned vector for a predetermined time;

상기 암세포에 잠재 물질을 접촉시키는 단계; 및Contacting the latent substance with the cancer cell; And

△Np63α 유전자의 위치가 핵에서 세포질로의 이동을 확인하는 단계를 포함하는 것을 특징으로 하는 항암제 스크리닝 방법에 관한 것이다.The position of the ΔNp63α gene relates to a method for screening an anticancer agent comprising the step of confirming migration from the nucleus to the cytoplasm.

제 1 양태로, 본 발명은 상피 세포 유래 암세포에서 잠재적인 항암제의 접촉에 의해 핵에서 세포질로 이동하는 서열번호 1의 △Np63α을 코딩하는 유전자에 관한 것이다. 바람직하게는 △Np63α에 의해 생성된 mRNA를 역전사하여 얻은 서열번호 2의 cDNA를 이용한다.In a first aspect, the invention relates to a gene encoding ΔNp63α of SEQ ID NO: 1 that migrates from the nucleus to the cytoplasm by contact of a potential anticancer agent in epithelial cell derived cancer cells. Preferably, cDNA of SEQ ID NO: 2 obtained by reverse transcription of mRNA produced by ΔNp63α is used.

본 발명에 따라 잠재적인 항암제란 암세포를 사멸시키기에 효과적인 물질을 말한다. Potential anticancer agents according to the present invention refer to substances effective for killing cancer cells.

제 2 양태로 본 발명은 상피 세포 유래 암세포에서 잠재적인 항암제의 접촉에 의해 핵에서 세포질로 이동하는 서열번호 3의 △Np63α 단백질에 관한 것이다.In a second aspect the present invention relates to the ΔNp63α protein of SEQ ID NO: 3, which migrates from the nucleus to the cytoplasm by contact of a potential anticancer agent in epithelial cell derived cancer cells.

제 3 양태로 본 발명은 상피 세포 유래 암세포에서 잠재적인 항암제의 접촉에 의해 핵에서 세포질로 이동하는 △Np63α 유전자와 이 유전자를 확인하기 위한 리포터 유전자를 포함하는 발현 벡터에 관한 것이다.In a third aspect, the present invention relates to an expression vector comprising a ΔNp63α gene that migrates from the nucleus to the cytoplasm by contact with a potential anticancer agent in epithelial cell-derived cancer cells and a reporter gene for identifying the gene.

본 발명에서 사용되는 벡터라는 용어는 또다른 핵산을 그것에 결합시켜 이송시킬 수 있는 핵산 분자를 의미한다. 발현벡터란 용어는 상기 벡터에 의해 운반되는 각 재조합형 유전자에 의해 암호화되는 단백질을 합성시킬 수 있는 플라스미드, 코스미드 또는 파아지를 포함한다. 바람직한 벡터는 그것이 결합된 핵산을 자기 복제 및 발현시킬 수 있는 벡터이다. The term vector, as used herein, refers to a nucleic acid molecule capable of binding and transferring another nucleic acid thereto. The term expression vector includes plasmids, cosmids or phages capable of synthesizing proteins encoded by each recombinant gene carried by the vector. Preferred vectors are vectors capable of self-replicating and expressing the nucleic acid to which they are bound.

제 4 양태로 본 발명은 상기 재조합 벡터로 형질전환된 상피 세포 유래 암세포에 관한 것이다.In a fourth aspect, the present invention relates to epithelial cell-derived cancer cells transformed with the recombinant vector.

본 발명에서 사용되는 '형질전환'이란 용어는 외래 DNA 또는 RNA가 세포에 흡수되어 세포의 유전형이 변화되는 것을 말한다.The term 'transformation' used in the present invention means that foreign DNA or RNA is absorbed into a cell and the genotype of the cell is changed.

적합한 상피 세포 유래 암세포로는 HeLa 세포, HaCAT, ZR-75-1, 또는 ME180이 포함되나, 이들로 제한되는 것은 아니다.Suitable epithelial cell derived cancer cells include, but are not limited to, HeLa cells, HaCAT, ZR-75-1, or ME180.

제 5 양태로 본 발명은 상피 세포 유래 암세포에서 잠재적인 항암제의 투여에 의해 △Np63α의 단백질이 핵에서 세포질로의 이동을 확인하는 것을 특징으로 하는 항암제 스크리닝 방법에 관한 것이다.In a fifth aspect, the present invention relates to a method for screening an anticancer agent, wherein the ΔNp63α protein is transferred from the nucleus to the cytoplasm by administration of a potential anticancer agent in epithelial cell-derived cancer cells.

세포질로의 이동을 확인하는 방법은 리포터 유전자를 이용하여 할 수 있다. 리포터 유전자는 특정한 유전자로 제한되지 않는다. 용이하게 측정할 수 있는 생성물을 발현하는 어떠한 유전자라도 이용되어질 수 있다. 적합한 리포터 유전자는 본 기술분야에서 숙련된 전문가에게 잘 알려져 있다. 리포터 유전자의 예로는 CAT(클로람페니콜 아세틸 트랜스퍼라아제), 루시퍼라아제, 베타-갈락토시다아제와 같은 다른 효소검출시스템; 세균성 루시퍼라아제, 알칼리성 포스파타제 및 녹색형광물질(GFP)이 포함되나 이들로 제한되는 것은 아니다. 리포터 유전자의 검출은 본 기술분야에서 숙련된 전문가에게 잘 알려져 있다. 리포터 유전자가 그의 효소활성에 의해 검출되는 경우에는, 일반적으로 효소를 그의 적절한 기질과 함께 제공하고, 반응생성물(예를들어 루시퍼라아제에 의해 생성된 빛)을 검출하는 단계를 포함한다. 검출은 리포터 유전자 생성물의 존재 또는 부재를 간단히 검출하는 단계를 포함할 수 있다. 또 다른 방법으로는 리포터 유전자 생성물의 발현 레벨의 정량화를 포함할 수도 있다. 정량화하는 방법은 절대적 정량화일 수 있거나, 하우스키핑 유전자의 발현 레벨에 비교하여 정량화 할 수 있다. 이러한 검출은 수동으로 수행될 수 있거나, 고처리량(high-throughput)선별 시스템에서와 같이 자동으로 수행될 수 있다.The method of confirming migration to the cytoplasm can be performed using a reporter gene. Reporter genes are not limited to specific genes. Any gene that expresses a product that can be easily measured can be used. Suitable reporter genes are well known to those skilled in the art. Examples of reporter genes include other enzyme detection systems such as CAT (chloramphenicol acetyl transferase), luciferase, beta-galactosidase; Bacterial luciferase, alkaline phosphatase and green fluorescent material (GFP) are included, but are not limited to these. Detection of reporter genes is well known to those skilled in the art. When a reporter gene is detected by its enzymatic activity, it generally comprises providing the enzyme with its appropriate substrate and detecting the reaction product (eg the light produced by luciferase). Detection can include simply detecting the presence or absence of the reporter gene product. Another method may include quantification of the expression level of the reporter gene product. The method of quantification can be absolute quantification or can be quantified compared to the expression level of the housekeeping gene. Such detection may be performed manually or may be performed automatically as in a high-throughput screening system.

유전자 발현의 존재, 부재 또는 정량화에 대한 고처리량 시험방법은 본 기술분야에서 숙련된 전문가에게 잘 알려져 있다. 예를들어, 미국특허 제 5,559,410호에는 단백질에 대한 고처리량 선별방법이 기술되어 있고, 미국 특허 제 5,585,635호에는 핵산결합에 대한 고처리량 선별방법이 기술되어 있다. 또한 미국특허 제 5,576,220호 및 5,541,061호에는 리간드/항체 결합에 대한 고처리량 선별 방법이 기술되어 있다.High throughput test methods for the presence, absence or quantification of gene expression are well known to those skilled in the art. For example, US Pat. No. 5,559,410 describes a high throughput screening method for proteins and US Pat. No. 5,585,635 describes a high throughput screening method for nucleic acid binding. U.S. Patents 5,576,220 and 5,541,061 also describe high throughput screening methods for ligand / antibody binding.

제 6 양태로 본 발명은 △Np63α 유전자와 이를 확인할 수 있는 리포터 유전자를 벡터에 클로닝시키는 단계;In a sixth aspect, the present invention provides a method comprising cloning a ΔNp63α gene and a reporter gene capable of identifying the same into a vector;

상기 클론된 벡터를 상피 세포 유래 암세포에 형질전환하여 발현시키는 단계;Transforming the cloned vector into epithelial cell-derived cancer cells and expressing the cloned vector;

제 7 양태로 본 발명은 상기 스크리닝 방법을 수행하기 위한 키트를 제공한다. In a seventh aspect, the present invention provides a kit for performing the above screening method.

이하, 본 발명을 실시예에 의하여 더욱 상세하게 설명한다. 단, 하기 실시예는 본 발명을 예시하는 것으로 본 발명의 내용이 하기 실시예에 의해 한정되는 것은 아니다.Hereinafter, the present invention will be described in more detail with reference to Examples. However, the following examples are illustrative of the present invention, and the content of the present invention is not limited by the following examples.

[참고예][Reference Example]

이전에 △Np63α을 다량 발현하고 있는 암세포인 ME180에 세포사멸을 유도하는 TNF-α(tumor necrosis factor-alpha)를 처리하여, △Np63α 단백질 양의 변화를 알아보았다. 그 결과 처리 시간이 지남에 따라 △Np63α의 양이 급속히 줄어들고, 이러한 △Np63α의 분해가 특정 기작, 즉 단백질분해체(proteasome)를 매개로 일어남을 확인하였다(도 1). 보통 단백질이 분해되는 기작으로는 크게 두 가지로 나뉠 수 있는데, 하나는 폴리-유비퀴틴화되어 단백질분해체(proteasome)으로 타켓팅이 되면 단백질분해효소(protease)에 의해 분해가 되는 기작과 카스파아제(caspase)에 의한 분해기작이 존재한다. Previously, TNF-α (tumor necrosis factor-alpha), which induces apoptosis, was treated in ME180, a cancer cell expressing a large amount of ΔNp63α, and the change of ΔNp63α protein amount was examined. As a result, the amount of ΔNp63α decreases rapidly as the treatment time passes, and it was confirmed that the decomposition of ΔNp63α occurs through a specific mechanism, that is, proteasome (FIG. 1). There are two major mechanisms by which proteins are degraded. One is poly-ubiquitination, which is targeted to proteasomes, and the other is the mechanism by which protease is broken down and caspase. There is a decomposition mechanism by

[실시예 1] 재조합 벡터의 제조 Example 1 Preparation of Recombinant Vector

벡터는 pEGFP C1(클론텍)을 이용하였다. pEGFP C1 벡터는 리포터 유전자으로서 EGFP(Enhanced green fluorescent protein)을 가지고 있어 발현될 경우 형광으로 관찰이 매우 용이하다. 이 EGFP 유전자의 3' 말단쪽에 위치한 MCS(multiple cloning site)에 제한효소인 Sal1 과 BamH1을 이용하여 우리가 발현시키고자 하는 유전자인, 서열번호 1의 DNp63a를 서브 클로닝하여 융합 단백질을 만들었다.The vector used pEGFP C1 (Clontech). The pEGFP C1 vector has an enhanced green fluorescent protein (EGFP) as a reporter gene, and thus is easily observed by fluorescence when expressed. The fusion protein was made by subcloning DNp63a of SEQ ID NO: 1 using Sal1 and BamH1, restriction enzymes, at the multiple cloning site (MCS) located at the 3 'end of the EGFP gene.

[실시예 2] 재조합벡터에 의해 형질전환 세포의 제조 Example 2 Preparation of Transformed Cell by Recombinant Vector

칼슘 클로라이드를 이용하여 대장균주인 DH10B를 CP 세포(competent cell)로 만든 뒤, 서브-클로닝한 pEGFP-DNp63a를 히트 쇼크의 방법으로 집어넣어 형질전환을 유도 하였다. 이 때 선택마터로는 카나마이신을 이용하였고, 나온 콜로니들을 배양하여 이를 인트론사의 미니프렙 키트를 사용하여 세포(CP cell) 안에 있는 플라스미드 DNA를 추출하였다. 추출한 플라스미드 DNA는 염기서열분석을 통하여 확인하였다. E. coli strain DH10B was transformed into CP cells using calcium chloride, and then sub-cloned pEGFP-DNp63a was put in a heat shock method to induce transformation. At this time, kanamycin was used as a selection marker, and colonies were extracted, and the plasmid DNA in the cells (CP cells) was extracted using a miniprep kit from Intron. The extracted plasmid DNA was confirmed by sequencing.

[실시예 3] 항암제 스크리닝 Example 3 Anticancer Screening

본 발명자들이 확립한 재조합 벡터는 pEGFP-C1 뒤에 DNp63가 융합 되어있다. GFP(Excitation maximum = 488 nm; emission maximum = 507 nm)는 특정 흡광도에서 녹색 파장을 발산해서 현미경 상에서 쉽게 확인할 수 있는 장점이 있다. 따라서 서브-클로닝된 pEGFP-DNp63a를 암세포주인 ME180에 퓨진 6(Fugene 6; Roche)를 이용하여 형질전환하였고, 488nm 파장에서 관찰하였다. 원래 세포내에 전반적으로 발현이 되는 GFP가 융합된 DNp63a로 인해 핵에서만 발현된다는 것을 확인하였고, 이때 TNF-a를 처리한 후 시간대별로 고정하여 DAPI가 함유되어 있는 마운팅 용액에 마운팅하여 현미경으로 확인하였다. In the recombinant vector established by the present inventors, DNp63 is fused after pEGFP-C1. GFP (Excitation maximum = 488 nm; emission maximum = 507 nm) is an advantage that can be easily seen on a microscope by emitting a green wavelength at a specific absorbance. Therefore, sub-cloned pEGFP-DNp63a was transformed into ME180, a cancer cell line, using Fugene 6 (Roche) and observed at 488 nm wavelength. It was confirmed that GFP, which is generally expressed in the cell, is expressed only in the nucleus due to the fused DNp63a. In this case, TNF-a was treated and fixed at each time, and then mounted in a mounting solution containing DAPI, and confirmed with a microscope.

세포사멸을 유도하는 신호에 대해 △Np63α의 세포내 위치 및 발현양상을 보았다. 즉 외부에서 △Np63α 유전자를 녹색 형광 단백질(GFP)이 발현되는 벡터에 콜로닝 시킨 뒤, 이것을 암세포에 형질전환 하여 일정시간 발현을 시키고, 세포사멸을 유도하는 TNF-α(tumor necrosis factor-alpha)를 처리한 후, 0h, 1h, 2h, 4h 간격으로 △Np63α 세포내 위치 및 변화양상을 형광 현미경으로 관찰하였다. 그 결과. 세포내에서 핵에만 존재한다고 알려진 △Np63α가 TNF-α 처리 후 2h 정도부터 세포질로 이동되어, 단백질분해체의 복합체로 보이는 아그리솜(aggreasome)와 유사한 양상을 띄는 것이 관찰되었다(도 2). 즉, 세포사멸 유도시 빠른 시간내에 세포내에서의 위치변화(핵→세포질)가 일어나 세포질에서 단백질분해체에 의해 분해가 된다는 것을 추정할 수 있다. The intracellular location and expression patterns of ΔNp63α were observed for signals that induce apoptosis. In other words, the ΔNp63α gene is colonized in a vector expressing a green fluorescent protein (GFP), and then transformed into a cancer cell to express for a predetermined time, and TNF-α (tumor necrosis factor-alpha) is induced. After the treatment, the ΔNp63α intracellular location and changes were observed under fluorescence microscopy at intervals of 0h, 1h, 2h, and 4h. As a result. ΔNp63α, which is known to exist only in the nucleus in the cell, was transferred to the cytoplasm from about 2h after TNF-α treatment, and it was observed to have a pattern similar to that of aggreasome, which appears to be a complex of proteolytic bodies (FIG. 2). In other words, it can be estimated that a change in position (nucleus-> cytoplasm) occurs within the cell within a short time upon induction of cell death and is degraded by proteolytic bodies in the cytoplasm.

따라서 이러한 △Np63α의 생화학적인 성질과 세포내에서의 위치변화를 이용하여, 여기에 사용된 TNF-α외에 다양하게 암세포 특이적 세포 사멸을 유도하는 항암제 스크리닝 시스템 구축시, 기존의 방법들보다 고효율적으로 항암제 스크리닝이 가능하다.Therefore, by utilizing the biochemical properties and intracellular positional changes of ΔNp63α, an anticancer screening system that induces cancer cell-specific cell death in addition to TNF-α used here is more efficient than conventional methods. Anticancer screening is possible.

<110> Seoul National University Industry Foundation <120> DNp63a Gene And Screening Methods of Anticancer Agent By Using It <130> PN050058 <140> PN050058 <141> 2005-05-25 <160> 3 <170> PatentIn version 3.2 <210> 1 <211> 107466 <212> DNA <213> Homo sapiens <400> 1 atgttgtacc tggaaaacaa tgcccagact caatttagtg aggtaaggat tttagatttt 60 agcactccat ttagagatgc tttttaattt ttatttttgt aaaaaaactt acgtatttgc 120 ggttctcggt cacccaatgt aatgttttgc aaattgtata taggaatctc cttttcttgg 180 ttaatgtttt ctgtggtggc tgtaagattt tttttttttt attaagtagg agatgaaaca 240 gtaggagaag atgaaaaaga aaatctgggt gacattatgt atttgaaaaa ataatattca 300 ggagtttata aaatcacttt ttagaaaaac agactcagag agcagatcac actctgctag 360 atacattgca atgaatcctc tgatgggtat tcatgtacca gtaagaaaaa tcagttgact 420 gtgtcttaac ttcttagcat agttctattt ccagacttca tcctaaaagc aaatgaagct 480 tttttcaaaa taatcaggtg agatttttta aagccatctt cgtttttaag tctgtcaatc 540 cagagaccca cctaaatcca gaaggggctg tgataacgtt tctgtcgtct ggagggtgac 600 ttgtactttc acgtgtgatg acaaataaag 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tctattcctt ttcccacaac 2340 ttttgaattc ttccccaacc cttagcagat ttggatttgg gggagctgct aattaacagg 2400 aaatggtccg gaagggagga gaacacaagc aggatataac aggcaaggct gaaggctcta 2460 cccttgggta cagcggagag gccgcaagca agctccactc cccagtgcca gactaggaaa 2520 gacagagcct ctgggaatgg tctcagactt ggagatagag agggtcaaaa taaaggaact 2580 tcttcacaga tcaagtttta acttcaactt tctggcaaaa caaaacaaaa caaaactggg 2640 ctgtgtgtgt ggtgtaagtg tgtatgtgtg tgagtgggga ggatctcaaa ctccttctta 2700 gaaagagata tttactaaaa ttcctcatcc ggggttttag atgatgaagg aaagacactt 2760 tggtaaatgg gttacagtat tttcgaacta aatgggaaat caaggttcat atatggaaac 2820 acctcatttt acaaatcagg gttaatgatt tttctttctg tagttgagag agctatatgt 2880 atacgatcgt gttcccttta ctcagccact ttctttttaa taccaaggag agatgggatg 2940 attcatagta gatgctccaa aacagtttcc atgaagaaca gttgtacaaa gccagttgaa 3000 tgcaagaaaa aaagtgtgga gacagcagtg taaactccct gtagtccagg tcattctcac 3060 ttaattgact tctttgtctg cttggtctag ggaaaaaaat ctgtcctgtc ctagtactat 3120 ttctactgac tcaaccattt aaaagatatg ggtgtgagtt ttctattgat agttaataaa 3180 tgtattaagc tgtcccatgt tgtacttctg agctagttag catcatagga aaaagcacag 3240 tgggtgagaa gcagaagctg catttttaat tagtgtcagc caggtcgtat tcctcactcc 3300 atgctgttgc catagattgc actacttgtt ttacagttgg ttgtcctcga gcccagaggg 3360 aactaggaga aagacatctt agatcacaga tcacagatca taccttcctt cactactact 3420 ggaaaaaaaa agattttgag acaataaatc acttatcctt tacctcgata aggaaaaccg 3480 tgtttggttt ggtttgcttt ttagaagagc agtgattctc aacagcatgt cacacgtaca 3540 gcagaaagca tcaatggatg tctacatttt ctagagcaac caaaaaaata ttggtttctt 3600 tttcattata cgtacatttt ctgaatgcaa agttgctaaa acattcctca atgactatgg 3660 acagaattta gattctgcgt tctgctataa agggagtata tatctaatgt catgagattt 3720 taaaaaggga tttggatcaa acagttgaga aatatgttac cacaaataca ccctggtttt 3780 ctttgatgtg catatgattg ctctgggtgg aatctgagct ggtagaatag aggggcacag 3840 gtaaaaatcc ttccttccta gtataacttt tctctcccct tgaatatttt taaatttcta 3900 attgttttat gtcaacaaat agaatgaata caggtaacaa aaagatactt ctgtgaaaaa 3960 caacttgatg atttccataa tttataagtt ttactatttt gaagataaaa aattgttaaa 4020 cccaagtggg cgctcaattt tctttagatg tatgttgagg aaaatgtcag ttgactaata 4080 tagcattatt gtccagtgcc aatttagtgg aacctacaaa tggtatccaa tagagtacta 4140 cattttgggt ctggaagagc atggattcaa gtgtcaaggt gaaacatttg attcaaaagt 4200 taagttttaa atcttattcc taatcttaag gacacaattt gtgggcccaa gaaaatagtg 4260 aaatgtggct tattaatggg ccaccactct aaacatttta taatttttac ttatactttt 4320 tgattaagtt ctatgttgac aatattcatg aaaagtagta ttgagaaaga gaaacaggtt 4380 agaagaagaa ctgactgact cttaaaaaaa tgtttactga gcatcaatta tatgtaaaat 4440 ggtatatagg atctaaaaat aattaagaaa taattcctac actaagaagt ttatagttct 4500 ttgggggaat gagctaagta tgcatgcaat tataatacag gagagatttt aagtgtgtga 4560 gcaagataat ataaagcatc aaagggaaag agagtccatg atgtaggaag atcaagaaag 4620 tctatatgca tatgtaagat gaagctgcac ttggaaggac agatggaaat ttccaagttc 4680 tagaaatata agaaggaatg aggattttag gtgaagaaat aagcatcagc aaagggaagg 4740 ggggtgagga gtgaatgctg gtacactcag aagcatcaaa tagttcaaat gcaattgaaa 4800 ttatgagacg atcaggaaat aaagttggaa atgcaagata gagtggctca gagatgacca 4860 taacactgag aggagagtac atttatcata gtgacaatga aaagccatgg aaggatttcg 4920 aacagaagaa tggtgtaatt gtgtaattgg agctctacta gagagcacag ggagaataaa 4980 tggctttgct tgagattgcc tagaagtatg aaaatgcatc tctctgcatt gcacattggc 5040 tgcctgtttt gcagaaatat ctatcagttc tcttggatct ttggaaggat acgcatggat 5100 tgtttctaaa gtctcataca acctgtgtat tttctgccca gtgctctttt taatagctat 5160 ggtccctgcc atagacaaat tgggaactac tggtcttggt ttgtctttat ttatgcctgc 5220 tattctagca taattactaa tagcacacct tttcactttc aaaactgtcc catttagaag 5280 ataaattata tagtcactct gtaaagaccc cattctttat ttcattctct tccacacact 5340 aacactccac cccaaaatga aaaagtagta taaatttggc tgtaagccag acacaatgat 5400 tttgaagtac cagccacaaa tcattttgat tatttccccc actaaaggaa acacttcctt 5460 ccaacccaac agttactgaa aacttataat agtcactgtt atatgcactg tgaggaaaga 5520 agaaattagt aattcacagc ttctagcctc cgtgaattca taatctgagg gagttatgag 5580 gggttcgtaa atgactccag tataaaacag aattggtaaa agatatccca agttttgaaa 5640 gagtgaaatc gagttcaaac tgtttatgat aaaggtaata ttttatatgg tttgagaact 5700 gaaattcaga tgtggcgtga ggggaggaaa gacattctat gtagagggga taaaatttat 5760 aaaaatacaa gggaggactg tgccagacaa cgtgaaggaa catagtatat tgatttaaaa 5820 agaaaatgtg ttggtttaaa cactgatatg tatttactat ttatgtcaaa atggaacgct 5880 tttgtagaaa tagcaacaaa agttaattgg aatattgatc tcactaagag cggaaaccta 5940 tatgtgtttt aaaagtgtga ccagtgttca gaattcgaga ttcaaaactt cacatactct 6000 agggatgatg agtgacatct tgcaggaagg aaaagaaaat tagcccgaat gattccttag 6060 gctgaaaagt tgaggattac cttttcccgt tccttagact tctacagagc cagatatggt 6120 gtcctatcat ttatagggac ttagtaatga cattttaaaa cttatcaaag ctaggaacaa 6180 aattcaaact gactctctgt gtttattatg agttaatttt atttattaaa tagtcgtctt 6240 agaaatagga ccagaagtct tttctctggt cactgctcta aatgcaaata gtaatcctga 6300 agctgaatat aagacattta ttcagaatga gaatcccagc tgggaaataa ataacagagc 6360 agagggaaat atgaatatcc catttaaaag ccaaccccac caaataaaaa atttaagata 6420 ttatctttgc cataaaattt ttaaatttga ctttgggaca aggatacatg tgtaagatgt 6480 aatatgtaaa gataaatatt gggagaagac atgtcttttc ccacatcaat atcctccctt 6540 tccacagcct ccttcatcac ttccatctca cccaagaaga ccacgtgggc aattgaagag 6600 ataataacag ggcaggggag ggtaggccat ggtgggagga aggagtgaac cagtgacttg 6660 atttaaagcc aaagggagtg gataagagaa ctgggcttca agataaataa ggagacatct 6720 aagctagtac tcatttcttt ctcttttttt taccaaccta atcctccact ttcaaaaagt 6780 agattttgaa agcatcaaat gttaacatat gattgtccta cagacattag gggaaacagt 6840 gaggttccac taaatacaac ctccttaaaa gaaataagta gttcaatgaa gtgtctgtaa 6900 aatcttttca aaagtcttac tttatacttc cccacagttg atttccttag ttggtctgag 6960 aatatagcac ctatactatt caaaaactat tcttttccat tttctgcaaa aaaaattata 7020 aatttcttat ttctaagttg attgattgca tgtttgatat ggactaactt tattctgatt 7080 ttgaagttgt tcaagcttct ttttcaaaga caaagtacaa atggatcatt gtatggattc 7140 gagctgagat ggcttcacca gataatgttc acctgtcaat ttaaaattca gtcactgggg 7200 ttaagataga gcacatgttg gttctaggtg agggaataac tggcaagaat aaaacatttt 7260 tggaatgtta gtgaatgtgt gtgtaacgta aattgatatt tcatgcaaaa cttgtaatct 7320 gaattgcatc ttgtctgtat ttcttaaatg gcaaaaagat ttccttataa aagctgaaag 7380 agggaatttt gagtcaagct gtggtgtgtt gccagaggcg gaaatttatg aaacactctt 7440 gtcagctatg ctggaaacac tacaaaagaa atagttctac tttcttattg gtgctaaagc 7500 cactaatagg tgcagtttag tataataccc ctatgagaat taccaccccc gaagtgagct 7560 tgccttggaa ggaactctgt acaggcattt tctttttcct tttaagcttg cgcaaaacac 7620 ccaaaggggc catttcccac ccagccagtg atctttctca agtttattct ttctcagatc 7680 acagagacaa tggggaatat gccctgttta ctcaaatcag tctggattag tgtcactcta 7740 ttgatggagt cagaattaaa aggaaaacca ttaccctctc aaagggcaac atcagatgtt 7800 tggggaatgg cgtgattact tttaaataga ccgtgtgaga ctctgtcacc agactgaggt 7860 tgaggactcc acaagacaca cttgaagaga aacagtaaca ctgggtgagg caggaagctc 7920 ttcataagcc ttaggcctgg gaaattattt caacagacaa tcccaaaatg cttgaaaggc 7980 tgaaaatcag aatggtgaga cttcagagaa gagggctttt ctgccttctt tctttgctcc 8040 aacacctcac ccccatatat ttatctccag gtcaaatcct ttccagtcat taagccctgc 8100 tggggagaaa cttaaccctg aaaaagctct cagattcccc cattcaggat aacacttcca 8160 tcctctgaac tcttttactc tgtttcttcc tcattgctct ctgtgtacac cagatccttc 8220 ctccctatcc tttgactgaa gaccctggga gggtagagga tgtgttatgc ttatctctgt 8280 atcccctaca gggccactca gtaatgttcc ctgaatgtga tgaggacatg catctgttgc 8340 tgttgcttga agggatatct tcacctagga atatatggtg tattgtatat acttaaaagg 8400 ctgtttgtaa ttgacttgtg cacaaaaata aataaagcga gccgacatat tatacaagcc 8460 tcttctatct atatgttctg caggtaaacc aaattgtgtc attttccttc acatcttgca 8520 ggtcatttgt ttttgctgtt tgtttgtttt aataagccca atattatttc cattatcttt 8580 taaatagcaa gaaagttttt gaaagacagg gcagatgatt tgtttggtat caagtaatta 8640 gtgtaaagta tgtgctgctt tcacataatt gattactcac aaggacagag aatgtgtttg 8700 attaaaaaaa agtcttagat ttttatcttg ctttgcaggc cctttttaaa agtgtttacc 8760 tgtgtctgca ctgttccctt gattcagttt atcccctgca gttctctctg tcctcaccag 8820 agatggggga agtttgatct gggtgaataa gcttgatgat ttgcaaacgc tctctccttt 8880 taattctcta tagtgttatc actaaaggat gtctgagaaa cctcaaagca atttttctct 8940 taaacgtggt attccaactt ttggttttgc tcatatcttt tataatagga caaatagaat 9000 aaaatgaata agacgagtgt cttttcaaaa gtaaggcatg tcttctgcat agctcaaaac 9060 ttgagtttta ttttgcagtt aaagtgacag ctgagaggaa cactccaatg ttatataggt 9120 caccatatct aattgcaaag taatcactaa aaactttaat tatctcaaat ataacttaaa 9180 aagtagcaat cagcaaagaa tttgacaaac aaaagcaaat tagaactcat gaaacagtgt 9240 tccccgcttg aatgcctata gtctaacaag attgagtagt acactccttg tttcaagcct 9300 cagttttcca gttgcaaata aaaactagtg tttcaacctt taagtgtttg ttatattgga 9360 gcataaattt atatcatttg caagaaagga tttataagtc tgataaacta taatctcagt 9420 tccttaaaca tacaatcaca aactgttaat tatggcttta ttctaaactg aattctggct 9480 aactgggcat aaaatcatgg aaattaggca gggagggacc aattttgtgg cctatctacc 9540 agaaactaaa tgtctttctc taagcttgtt tctgggtggt ttcttttcaa agcaacctgc 9600 atttggccat gtgctccatc agtaggaagt gaataattat atgaccacaa agatataggt 9660 tcttattgct gacctaggtg cattcgaaac aaaacctaga ccatcaggtt aaaaaacact 9720 gccttggcac aaaagtgtgt atgtgtttgt tttaaggaag tagaagctca ttaataaact 9780 tcccagctag gtgtgagcta ccaagtatta ctcattgtat tgtgagtgac aggactggct 9840 attctgctac tagttcccat aaaagctgaa gctaaaagca caattcccac ctaccaagac 9900 aaagctaaac aaaaagtaaa gatcatagag attatttagg gatgcactat aacatttgtc 9960 tgacagtagc atataaagaa atgaatcaaa tttggacaca gactcaggat aaaataaatg 10020 atcagttgta ttagaataaa agagatactt tctgcaagta attttcatgt tgaagtgttt 10080 tgcatttatt cttttaagaa ctgtctcctg agcatctatt atgtttcagc cattatccca 10140 ggtattgggg attcagtact aaacaggcca gatatattct ctcattaact tattgcctag 10200 cagagaagac caacattttt aaaagtttat acatatagtt aatttctatt atgattatat 10260 gatacaaatg gaaagtgcta tgaaaatgtg gaacaaaaga gaataatctg tctgaacagt 10320 caaagaagac ttctgggaga tgacatctga gctaaaggtt gaacaaggaa ttggaaaaca 10380 gctggcatgt gcaaaagact tgaagactga aggagttagc ctttaaaaaa atgaagaaag 10440 ttctatttgg ccagagcaga gtttcaaata gtgcctcaca ggccacgtta aagacctgag 10500 gcctttattc taggagaata gggagctgct caaggaattt aagcttgaga gtgacaagat 10560 cagatttgca atgcctttca agtggtagtt acaaggagtt gggtctctga ccctttgcaa 10620 ttatacccat tctaactaag aatggggaaa cttttatatc ctgtctttaa tgagtaaaaa 10680 aaaaaaaaag aaaaaaaaag caaataaaag aggtgcgctt ttcttgattg taactttcag 10740 ataaaaattc caggcagaaa tgtgagtgat tcctatttac atgcagtcgg aatgaaagct 10800 acttaggaaa gcgggttccg gagccagatt tactggttcg acatccaggc tcttctcact 10860 accttgggcg agttacttaa ccttgtggag cttcagtttc ctcatctata aaacatggat 10920 aaaacatgga tattaatgcc atgtgtctca tgagaaataa gtaaaaccat gcaaagcact 10980 tgaacactct aagacacata cttagaactc cgtaagagaa ttaataatag tagaagtaat 11040 tgctcatttt cttttataga ggggatggaa gatggatgat aagtagattt cagagtttta 11100 aaatttattt ttatttttat tttttgctcc tgatagtcac cattacttta ttgaaactga 11160 tatgtcttca gtttcatgtc atggtaacga aagcttattt tctgtgataa aatgttaatc 11220 acatttaatc acccgttgtt ttaagtcaca atttaggata tgaactagac aaatatacta 11280 ccaacattat ttaaaaaata tttttaaact cactttccaa accaaggatg cattactgct 11340 gggcttctaa aggcagtatg gtatgcttaa cataaagatg gcttaacatt cattgaagaa 11400 ttttattact atgtactttc ttcttttaat attaccatat ctgctatata gagctatgaa 11460 aacatattga ttgctataga ttgaaaatct cttcaaacat attttgattc acttggaata 11520 aactgaaatt ctgaatattt cccctaatac cagaattaaa aattattaaa tattaaaatt 11580 ctatcctgct ttctgcttag tttgatactt ctttgatata aaatgataat aattccttca 11640 gaattgggat gccttctgat tttcattttg ttgagttgtt atgattatta taggagtatg 11700 tactaaaata atataatttt aaaatttatt tttcttaatt gagttctaca cattttaatt 11760 tagctgcatt tggatcaagt tttaatttta atacctttcc cacttcctgt cttttcaaat 11820 gttgtgtcaa atgtttgttg acattgttgt ccacctgatc agacaacttt gtatttattt 11880 ctctcacctg ccgttggggc ttctagagct ctttctccta aattatggaa tcttggcact 11940 caaaggaatc ttgacacttt gtgtcagaac acaggacatc tagtgaactc tctgcttaca 12000 gtcttgatag ttttgggtgc gtttaaatac tttattctta tattttgttc tttgtatgag 12060 tatatattaa gtattcactt tttatataat tttagaaaac aaaatgagtg acatatttta 12120 tacctaataa aatctggttt tgagaaaaat gtgatgctac ataaattctt cggttggaaa 12180 gatggtgttt taacttgacg tttgaatacc aatatatttt cttaacctgg agtagaacac 12240 tgtaagtcaa ttgtgtttaa ttctagcata aaagaaacca tcattctctg aggtggggca 12300 ggtggcagaa gacgaaaaaa tgacaagtat gtctccctta ggcagtgctt gttgaaaagt 12360 cactatcctg ctgatatttg gggatggaaa tgtagtactc tctgctaaag cataattgaa 12420 tgaatgcttt taaagccagg gtcatcaagt aaagctgttt tctttaccca tgagggactg 12480 tagaatgttc ataaaagcac ctccgtgaag cctcaggtga aaggtggtta tcagctgagg 12540 aaactgtatg tgctgcctaa aatgttttag atttctaagt ttggtcaggg acatctgtat 12600 agagagagaa cagttacctt agaaaactgt tttgaatgtg gtcttatagc attgttttaa 12660 cgtagcttca cagatgagga tggccataag tcacagaatg ttagaactgg agatccctct 12720 cattgaatcc tcaaattcag tctcctcaat tttacacaga ctttggatta tggtaaacta 12780 aggtccacaa gttgttcagc taccttgccc agaggtacac agcacactag tggcagtgtt 12840 gggacttaga ctccatgtaa agaagtttaa gttcagaatt cttttgcatc actaggatcc 12900 atacaggagt gtaaggagta ctgaagcgtg ttcaatcccc tagcctcatc caccagtcac 12960 tcatggatta taaatacaat ttcttccaag tgaaatttgg gaatactgtt gtatcttgta 13020 acaaaggtct ggttgaatcg agataagtta tgattatata tcccaacagt aatctcttct 13080 acccctgatt tggtccctat cccatttttt taataacctc ttactatata ttgttgacta 13140 ttgttgctat agtgtcataa atttactatt atagatagta atatctgaaa aaggggacat 13200 tttaaaaaat tctcttggcc aggtgtggtg tctcacacct ttaatcccaa cactttggga 13260 ggctgaggca ggtggatcac ctgaggtcgg gagtttgaga ccagcccgac caacatggag 13320 aaaccacatc tctactaaaa atacaaaatc agccgggcat ggtggcacct gcctgtaatc 13380 ctagctactc aggaggctga gggaggagaa tctcttgaac ctgggaggca gaggttgtgg 13440 tgacccaaga tcgtgccatt gcactccagc ctgggcaaca agagtgaaac tccatctcaa 13500 agaaaaaaaa ttatctttta cagataaatt ggtggagaga gattttcaaa aacacaaatt 13560 ataggtaaat acctatttct attgcattgg tcaaatagct tcattggaat ctctttttga 13620 tgttaaatac ttttatagga aaataattac gtcatcaact ttaagtaaat ataaatccaa 13680 ttatttaata ttgagttata gcaatatata ttgacacagt tttgtttctt catggtgaaa 13740 acagtttgag attcagctcc tgggtatctt tatacctacc atgcaagctg tatgtttcag 13800 aatgccctca gggtgttcta tgattgcagg gaatatgtcg agtccatgtg accaaggcgt 13860 acttcatcct ttctgtgatc agatcagcta gtttgtgagg aacctgaata tatcacaact 13920 acaaataaat tttccagggt ccaaacagtg attcttctat ttcaaagtta ttttatagaa 13980 aatgaagcat ctgtttggaa tcacaggaaa ttattttact ttataagttt cacagtagat 14040 atcacagaag ttgtgttcat ttttgccttt atgttttgtg gaaagaatac tgcctctttt 14100 ttcagacatg ctgagataga tatataatgt ttccattcac tcattatttg ggtgtctgca 14160 gggtatgtta aggttattcc aaaatcaaga tgccttgtgt ttagaaaggg agaacctgct 14220 tcctatttca tttcagatac gccaataact tttgttacct aagaaataca tgcatatggg 14280 acatgggggc tctatggagt tcttccaaag gccgttttta tggctgatct gaaagtatag 14340 tgttctaatc tctgagactg actctttgac ttgtcattgt cagtaagcat tgcattaaca 14400 tcccagcata ttacacattt ctctcctctg ttatggaatt attggctgta aataaggcaa 14460 gaggtactgc tccctttacc ccgccagatt tgctgtgata gaaaataagg gatagatatt 14520 attcacttga cctgggacag cttcatgggc ataaaaactg caattggtca cacagggccc 14580 tatcttagaa aagcaccatt ctttgtttaa tgctttgcta tcatcatttt gaaattctta 14640 atctatgaac aagaggttct gcattttcat cttgcactga gcactacaaa ttgtacaaat 14700 tgttttgctg gacctgtctg ggtgacactt gttcttcttg actataatgg ccagcccttg 14760 gcttccaatt gtaccctgtt aacacacgcg atctttcttt aaatcaaagg aataagtgaa 14820 taagaatatt ttctttaaac tagatatttt aaaaattaac ttctgaagaa tgaatttatt 14880 gatttttaat aaactaagaa aatatgtaaa tggatttcca gtcattcagt tctgactttg 14940 gtgggtttgt tgttgtttct gttcatttta agctaacatt caaagttagt agtgtcagtt 15000 ttacgctttc caggaaaaga caacggagta tactacttgg cttatatttc tgtaaagtat 15060 cacttgagaa gcgtttcaac tgaaatgtgt tttcccactt tgattgtgtg tagtaggctg 15120 atttctcatc aatcctaaga aatatacctt tatgttatat taattgagga tttagcattg 15180 gtaacaaatc ttgtttttct tacgtacaaa atctcccttg ggactggata taatttaaaa 15240 ctatgacgcc taaaagtaga tccatcagta cccacattgc tattcatgac ttttgaaata 15300 cagtttctgc ttctttgttg cttctcaatg gttcagtctt tctatcattc caaaggactc 15360 ttgtgactcc tcagtaaatg gaattttccc tttcttttcc ttaatatcca taaaatcagt 15420 ttactcaaga aattatatag cagtatacag cctaaaccct ttctcaaaat tgtcactagc 15480 ttttcttatt cattaaaaca ttttcatctc attacaaatg atttcttcct ttaaaatttc 15540 ccagaaagta tggcctctgt attttctgct gctcagttta aacacatcat caaagacaga 15600 taattattaa tgtcatatga gcataacagg agatttataa atcagaaatg tattttctgg 15660 gaaccaactt tcaagttagt caggtaagtt ttattaactt cactggtgaa gtcctaggat 15720 aaagcagtgc ctagatcagg cttgtttacc cttggcctta tatggcacca aacactgttt 15780 caggacagtg gaagaacagc ctgggaggcc ttcggccttg gccagccttg ccgaggcccg 15840 ctcaccagga gaaataggaa ggaaggccag tgagtgtgca aaggagcatg gcttattttg 15900 aggtcctgaa ggccagtgag tgtgcaaagg agcatggctt attttgaggt cctgctgatt 15960 gcaggccaac aaaacaatgg caggatttga aggaagaaag tattgcaaca gagtcaccgt 16020 atactttgaa ctgcaaaggg agactgagga aatgttgcct caaggccaaa aaccctggct 16080 caaaacacag gttcctcagg tgactcagag gcagaccaag ttcaccaagt caaggacatt 16140 ttcctgctac ccccctgggg agaggggcct tcaccaaacc accctggaca tggatctcct 16200 gctgttcaga acccacccaa taaacaacag aagcaaacac tttttttttt tttttttttt 16260 tttttttgcc ccttacacgg aattgtccct ttttgtaagt ccttgttgaa ttgaagagtg 16320 tttgctcact ggcttttaaa gtgtggtccc aaaacttttt tcttcgttta tattgggtta 16380 aaaaaaaaat caaggggccc atgcgtcttt gttctcatcc aagcccacaa ttagttagct 16440 ggggttcctt ctgtgtagct agaagcagga gggaaggggg tggcccagca ggcattttac 16500 tgcctgcgag aaagtgctgt gagtttcttt gtcctttttg tcagggacgg ctgcctccct 16560 aattgtactg ctgtagggag gcacgtgcct ttgggagcat tatctgattc ctacaggacg 16620 ttcaagagtg ctttgtatac tgacccttaa cttgaacaca aagaatatct tttcaatccc 16680 cttccgaggc tgttgcctca ggcttggata cctaagagct ttagttcagc cggggtatgg 16740 accatttata tgggctcagg ttttattttt ttgtccccta gttgtcttac ctgcagtttg 16800 gccacacctg ccgggagaga aagctgaaga tggtgggtaa gtggtggata gcagctatag 16860 aagtcagaag ggagagaaag cgagacaaac agctgctctt gtcagcatgg ggataagtgt 16920 aaagagatta atagttattt gaagagcaaa tggggacatg gcattcggca gtggaatgcg 16980 aatgcatgaa tgtaatggaa tgagcatgtg actattaaca tttagacaaa tgcttcctgg 17040 actgaatgga atggcaaagc ccacttctcc tccccctgtg gaaaaaaaaa agttcaataa 17100 aataattaaa agtttgaaat ttttaaaaag ataagcctag ctcctatttc tttgtaagtt 17160 tgttcttctc tatagtttta cttaatctgg gactctcagt tacatttcaa ctgaagagct 17220 aggcctattt cctttataaa atatgtacga ataggactgc cttaatcttg cttttgattt 17280 ttttttctca ttcattaggt tgatgaaaca agatttctat gtgtcggaag gttttacaaa 17340 ggaaaagcaa ctgtaccata agctggttgc ccctttgttc attttggctc aggtttagaa 17400 atgatgatag gctgatttgc ctactcaggc tgacagtttt gatggcatgg acagagccct 17460 gaagtcagaa ccagaagatt cagcaccgaa agccccagtc attgtgttag cggatgctag 17520 ggcaaatgct ctacctctcc gatagtaata tagtcaagtt ttttgtagag taaatgaggc 17580 aaaattaatt tattctttca taaatatgtt cttgagtact tttactctgt gcttgggccc 17640 attcacatag aagacataaa aacgtttggc agaaggaaat acatgagcta atgtattttt 17700 gaattatatt gaccatagaa ttttcttcat aagtagttgg tatttctctt acaaatgttc 17760 tactctagaa aagaataaat ttctattaag aaaatgaaag aacaaataaa aaagaattag 17820 accagtttgg atgatttact agcatgttac tttttaaaat acatagttgg gtgtccctaa 17880 ccccgctacc catgatcctc cagtctttgt gaaaccagtc cttagggggc tgggtggtac 17940 actcttggta ctctgggaca gaatgcagaa ttgcaagatt aagagaaaat tcgaaggtca 18000 tttgattttg ccccctatgc aacaatttaa cacttaaatc ccctctggaa catacctatc 18060 aagtggtctt tctcattttg tgtaacacgc cccaaccccc accaacaacc tcaaaatgga 18120 atagcaggca gtatttattt aaagacttcc taagcagcta ctgagcactg ggaacgtttt 18180 gcctagtttg tgaataagca tatactctac tttcaaatgc tctgtaggaa gtcagtctcc 18240 agaggtggca catagagctg agtgatctgg aaaagccgtt acaaacacac acatgctcag 18300 acttctcttg ttttctctgt ttaccaaaaa tcaacggttt tactttgaat gtgaagtgct 18360 tccgacgtga ggtccatctc tgtagaatgc attcacccat ggatgccttt ttttggagca 18420 atgatccgtg gcttcagcgg ctaatattgg ggtttctggg tgtccttgca gccacagtac 18480 acgaacctgg ggctcctgaa cagcatggac cagcagattc agaacggctc ctcgtccacc 18540 agtccctata acacagacca cgcgcagaac agcgtcacgg cgccctcgcc ctacgcacag 18600 cccagctcca ccttcgatgc tctctctcca tcacccgcca tcccctccaa caccgactac 18660 ccaggcccgc acagtttcga cgtgtccttc cagcagtcga gcaccgccaa gtcggccacc 18720 tggacggtaa gagcagcggg cacgcacata cctgaccccc caagtccaag gatgggcttc 18780 accacgtccc agggatttct cccccttccc agtttagcga ttccatgttc atggtggaaa 18840 atttgtcttt gaatatttaa tactgaacca gagagagaga aagtgccagt tagtgggaaa 18900 agtcccaatt taggaaccaa acgtctgcgt tctagccagc tcctggcaac ttcagtcagt 18960 gtgttcctgc ctgcttcaca ctgttgtatg tgaaagttca tggcaaggta aagagcgctg 19020 tgccaacaag aagtatcata atcatgggat atgtgtttac agtctccaga acgtgaacgt 19080 gtttaccagt ctcattcttg taaagaagta agtgtcacat taagttgtga ttttaaaaac 19140 tgagtaaaat aataaatata gtgttataaa aattaagaaa ataaaatccc atttatgaag 19200 gaaggatgaa tatgtttata catgtaggta tcaataaatt ataatttatc agtaaattgt 19260 ataatgtctt ataaattact atttataatt tatcagtgaa ttataattta ttgatatgta 19320 tatatttatt taatttggaa acattctttt cgaaaagaaa gcctttaaat agacatatca 19380 gagccctgaa ttagtccaaa gaaattgtta aagaaaaatc tttctgcata taagttttct 19440 aaggaagcat ggaattttct tttcataaat taggaagata caagaattag tccaaagaaa 19500 ttgttttaaa aaatctttct gtatataact tttctaagga agcatggaat tttctttttc 19560 ataactagat ccaagaatat tttattttga agtgtatttt gaaatgtatt ataacaagaa 19620 taaagctcaa gtataaaaga ggacacctac aaagttggtt ttaactggtt gatcaaagaa 19680 tgttcaagac caaagtggta tgtttgtcaa acaacttaat caagaccaaa gtggtatgtt 19740 tgtcaaacaa cttaatgttt acatggatta tagaaatgct tccaaatatc atcatcttaa 19800 taaaaagtag ctttagaatt gttttgacag ttttttccct ctttgacaaa tggatttctt 19860 tggaaagcat ttctatgttt atgttatata tagtatctag ttcattccag cctttagttt 19920 gtatagttta taaaatgatc ggcatgccta agacctatta cactctaaca tcatttcaca 19980 tccatttcct ctttttcacc tcatttcttt gtgaagtacc caggacaagt tttataactt 20040 ccactgtgct agtgaggaaa gctgaagaag ttggaggtta agttaagagg catgcctaaa 20100 cttacagaaa cttgtgtgta gctgggcctg tttttcattt ctgcttccct ctcactggat 20160 tgtatccttt ctttcaacca ttttatatca ggatctccca aaattgtcta aaaattaatg 20220 ttattttagt tctttcctct tgtggtttga gaagtaattc tccggtggct catatttcaa 20280 ctgtagagca tgaacatcag cttaaaactt gatctctcct ccacgtgtta cttatcaatg 20340 gagtcataat ccttagtttc ctttactttt ataattctgg aggcgatgga tactgcaggt 20400 gagtaaactt agagtttata ggcttcaaat agttggttga ttgatctaag tagtatcttg 20460 ctaaagagcc actagaataa ccattttata aatggagcac tgatatctct taggtcacca 20520 accggacatt tacagtcacc agtcttcaaa gctaacagtt actaattcag tttactccgc 20580 caggtctcca ttatattagg agtcagcatg tctgatgaga tgatgggcat attagggctg 20640 ctaaatgaat aatcgctttt tttccctgta aaatttttag aaaaccatgg ggatgaatct 20700 tgatgtaagt tcaacatcaa attagttatc cttccctgtc ccttcctcac tacctcctca 20760 tatagaaatc ttaaaagccg ggcgtggtgg ctcacaccta taatcccagc actttgggag 20820 gctgaggcag gcagatcacg aggtcaggag ttcaagacca gcctggccaa catagtgaaa 20880 ccctgtctgt actaaaaata caaaaattag ccagacgtgg tggtgggtgc ctgtagtctc 20940 agctactggg gagactgaga aaggagaatc acttgaacct gggagacaga ggttgtggcg 21000 agctgagatc gcaccactac atgtgatctg cctgcacaat agaacaagag tccgtctcca 21060 aaaaaaaaaa aaaaattaaa gttattttca ggtttagcat aatcctaaac catcactcaa 21120 agcccctctc tcagagaagt caattgtctt actcaaaaag ttggagatct ctaccaaaat 21180 gttaggttta aaagaaaaga aaatattctg gtacactggt aaaatttcct tacatgtgac 21240 agcagtaata tcagtgccct gacaaaaggg atacactgtg gtgatgagaa aaaggcactg 21300 actgagagac agaaaacctg gattatggtc ttgatcattt atgcaaactt agccaagtca 21360 cttgatcttt ctaaaattca gtctgtgcct cagatgagaa agaggatgag aatggagaaa 21420 cctactctgt tttcttaagg tgagatgata gtattaataa ttaacgtaga aagtttttag 21480 aagggctttg gttcgcatcg atatattgtc tgccattcat gagtgtcctt ggttaagtga 21540 ttttgcttct cttggatttt tgttcacttt tctgcattct acctataaat tttacaatca 21600 ggtttctact cacatatcac atggtaatta tatttttatt aaatttcttt cttgttcaca 21660 accaggctta tttcaggccc agttcatttc ttctaaatta gggcacttga acccttatct 21720 gagcagctac tgagatcacc taaaaagatg taagttcttc gtcatggata cctgcatctt 21780 agcttctaat tctttgagcc aaattatata tcctcatgtt tatacacaga cttcccattt 21840 taaaaagtat tttttcatat atttatctta gttgagcctc ataaccaagt ttgtaatccc 21900 cagttttata gatgaggaaa cttgaagatg taaaggtcac atggctaata accagccaag 21960 gatggggaag aatccaggcc tccctcaccc taattcaagt ctctccacca tcctagttag 22020 actgtttctc ctctggtttg agaccaggga ggggcataca ggagcaggca gtgcctgtgt 22080 agtttggagc ttgcctctta tgtcccagag tccaactggt aaagaaattt tttgtgcctt 22140 attatacaac acctatttct taggcatttg tgcattttag agcaattttt caaaataaaa 22200 tgctgcattt tagaactgcc cacaaactga aagaaacaga agctgctgtc attaggggga 22260 gatcatgctt atcgcatagt cttctggtaa ttctttaata aaaatatttt tagtaccatt 22320 ttatcacttg caatcctttt atgtcaagtt ttctttttta acttttctgg ttttaccctc 22380 aggattactg tcaaaatata gctaatatat ttaaagtata tgtgcatttt tcctttgcgt 22440 ttctgtgttt taaataacaa atgtgattat gtttccagtt ctacaaaaat atggtattta 22500 ttttaaactt ctttcaatga aatgaagtaa aataagacaa catttttcat cttctctgtt 22560 tcacacacac atacatacac gacaaaccaa cgtttacttt agtttcagat tttcttattt 22620 ccacaattta attgatacta gttacagagg cctatcattt aatataatgt agtgctggtc 22680 tagcattgta gttgggaatc gttaatcata ggacagttga aagaatggta gtgtggagat 22740 ggcaagaaac ttaaattcag atttcaactc ggaaacttac taacagcata tggggctttc 22800 accaaaaatt caatctctct aaacctcact tttctcacct acaaatggga acaaatggga 22860 acattaatac tttccttatc atgaggatta cttcatgtaa acatacctat tagcacctag 22920 ctactcatat gctcccaagt gtttattggg tctgaatttg aatttcttcg gttcgtgagt 22980 tcattgtagt tttgttgagg cttcgacaaa actttagtac ctttagttgt actaaaggta 23040 ctcatttgag agaatgaaaa ataaaatttc aactaatgtt ttttcttaaa gcttttgggc 23100 tattaacatg catactttat agagggactg tgatactatc cactatccaa atatatgaat 23160 agatggtata gggtgataac agcctctcct gcatgcagac ttctgcaggc tggctctgct 23220 gctttccgaa gcctgcccaa gcagatgtag gctctccttg ccagtgcaag gagaggccct 23280 ttccagattt aagaacctgt tgatttttga cattcgttcc tcatttttaa tctgatgctt 23340 catgatggga atgccttttt gtattctttg tgttaaggaa taacagtggg ccttacttat 23400 ggcagactca agatattaat gtataatgac aaactactgg aagcaacctg atcagtcacc 23460 cgtgaaaaac tagatggcat gttataagca ataaccatac ggccattaga aagaattctc 23520 tgtactgata aggaaagctt tgggagttgc tggtgaggga aaaagaaagc tttctgtggc 23580 acctgcttga gaattgagag tcctggtaag gaaccccact tgtaggggcg gtgtttcttt 23640 gtgctcccct ctagtgatga ggcttcttgg tgaacatagt tcagtctgtc ttgattattg 23700 gcctcacaca cctttgccag ttggagagct atttttcacc gctcatgaca cgagagtact 23760 ctctgtgtgc atacgccatg aaaatcctca ggttgttttt ttttttgcat tgttttgttt 23820 tttaaattgt gttcagactg aagtaaggac cctacccttg ggacatagga tcactttttg 23880 ctgttgtatc tttctcctgt cattgacctc aaggtcttgt atggcagact ccctgatcta 23940 gtgcccagca caatgtccag cacacagtaa acctttaata aatgggaagg aacttttttt 24000 ctctcataat taaaggaaac aattgtagtt cccagcagga gccctcaatt ctgactctga 24060 ttgttaactg cccgtgaatt tgttccctgt agccttcacc catgatttat agagagtgtt 24120 cttcctttgc ctttcttaac catgccagct tcgtgtcatg ttcagagctg tggagaattt 24180 gacttgagca agtggagaga ttagggaggt ggcgtttgaa aggggaacag ccagttcccg 24240 ggagagttcc attgatccca gcatatgggt cttggtctcg caagctcact ccctttggct 24300 ccgcaggcag gctgagatgc gcgcctgcgg cccaccctcc ctgtcatcag gttacctgta 24360 atgtaagact tttagaaaaa ggctgccagc tctgcagaaa tctaatgcaa cccagccaat 24420 tgcgtggccc tctggaattt agagactctt aagaatagcc catcaaagga caagatgtac 24480 agacaaactc ttcgatggta aataggattt atcagttttc tttcacagtg gaagcacttc 24540 ccccattaaa gtctgagtct catctggggc ttgatctaat cttacaattc agtggctgtt 24600 agattttatt ggtgaggggc agaagtcagt agctcgtgcc actggtacat gtgttcgtgt 24660 ttatcataac aagataattt ttacttcttg ccatagctgt ttcataaatt atgtgagatg 24720 tgtatcaggt gcctttttgt gccactccca tgatgaagaa aataatagca ttgagcatat 24780 taatctgtta tctaaactat ttcttagttc acagagtatt gaggaagaat gtactaaata 24840 aagtgcttag agatttttgg tgatggttca agtaacttac ctctaggttt tggatttaaa 24900 atgaatattc attgtaaggc atgcttccga agagttgttc cctcatccag agcagaataa 24960 ctgaatcagc gttcttgcct gagttttaga ttgactctag gttaacgtat tcgtgatgag 25020 ccagtttaat ctaatctaag gcttatcagc ctcccatact attttgagtg atttgttcac 25080 tgcaccgtgg agtgtctatt taacattaaa ctgatcttga tttattgcat gtgaacatta 25140 taaaaactat tgattttaaa aatgaataat ttaaataaag cttatatttc ttttcctact 25200 acaaagagta acagcaaaaa tcctctgctt ttcccttttc ttctttctcc ctattcttct 25260 cctcttcccg catttcttct cccccttctt tctactccct ccttctcttt tttccttcat 25320 ttatgttatt attgttagtt aatttggttt tgtaggtatc atcagctaca tggtatcttt 25380 ctttattttt ttttactata gcttcactct tctccataaa ttaatatgga gaacatgata 25440 tatatcaatc accgtggaaa tttttatcag gattaaatta tcacaacctt ttcatgtaac 25500 aaatcacttt ggtgaataat aatgggctgc tttagaggta gcaaacccaa atgtcattgg 25560 agtcagggag gtagcataaa tgagccgaat gataagtaca gaaactgtgg caaaagagct 25620 tatatactgt atctacaagg acatctgctt tacaatccca gactgttgtc acaggggaaa 25680 gtagacctag tattaaaata tttaaaatat taaattaatt atcacaatat taactcttaa 25740 atattaattt ttaaaagagt aactagaaac ctgggtttgc atgtaatatc ttcatatctt 25800 aaaatgatga tactaattca aaaaaaagtt gtaaaacact acaggccaaa caaaacagta 25860 cacaggctgc atgccatcct gtgcaaggtg ttaatggtaa caaggggaga ttactaaatg 25920 tttaaataaa ttaattggaa gttagttatt aaaataacta aaataactgg aatcagcatc 25980 taagagaaag gttactagtg ggtatatttt attcacaagt aataattctt tattccttta 26040 caaagtcata tagattaatc tcttgctgca tttaactaag caatacatta tcagaacata 26100 tttttctcaa cttgttttct tacagcaaat gacctttctg cttctcattt ttatatcatt 26160 ttatatttta aaaatctaat ggcatgcagg attggatact tggaagttta ttgtttgttt 26220 gttcctgtgc ttatcattag agaattatgg aactctgtaa cttaactcct taaaattggc 26280 caaagttgca ctcagaaaag agctttgaga tttaaagggc ttctaatcaa ttttctcagc 26340 ttactaacag atagcttact tttaattggc acatagtgtg ccagaacaaa aatcatctga 26400 taattgaagt ataaagagaa aataatgtca taagaacttt taatgactct ggaaaactat 26460 atcattaagc tcaaaagaga tcccttaaaa tgaatgcaaa cttaaaatcg gccctgagtg 26520 atgtgtacca tttattgtgg gattgtcgct cttggtacat ttccatacat gagctttgca 26580 cattctcctg ttcgcattcc ccaaattagg ttatttccat aacgtgacca agtctatgca 26640 attgttccta cccgctttgg taaagggccg atgtatgttt ctcatgaaaa gtcctcagca 26700 gttacagctg tcatatcgcg agtaaaacca tataactata tataaaaacc ccctggtttt 26760 atattagcag caattggtat gtctagtcag gtcactgtga ctgaaaggag acttgagata 26820 atgtagcttt ccaacaactt ccaattcttc aaaattaaag aagagtttat tgtagaatag 26880 aaagatagaa agataattct tcagttcttt gaagccctgc agacattttg tagatatgga 26940 atggttttta gaatgatgga tcctgtaatg aggcacacag aggcgtaaag gtaatgatct 27000 tagtagattt ctctcttgtg gtttttagta atgatcatga ccttatcatt aagcccccca 27060 cgtgaaattt aaaagaaaat ttgatagtag tcagagaccc tagatctaat ttattgtgag 27120 gtaaattagg gagggattct gactttacag atagaatgag acttctcatt ttagtctgaa 27180 tttaataatg aagattcatg tgggggaaaa aaaaaaccct acaacttgcc accttgttat 27240 tgtatcagaa aggcctgaaa acagagcagg gaccttaatt gctaattgtg ttagtaccaa 27300 cctttcaagt tcattgatta aataggagtt ccttcttgga ttaatgccta agtttttatt 27360 tttgttttgc ttcatgtgct gttcagccag tatcatctgc attgaatctt ataaaaacta 27420 taatgaataa gttgaggaga ctatttctaa agacttttcc tttgagtggt ttccaagttg 27480 tattaaataa gaagactaat gattacttaa gggttctcat ttgaatttga gaagacatct 27540 gacaggctcc tgaggagtgt gactcattaa gtagaatacg ggactcagaa ggacaacttt 27600 ggggtactaa caagctatat gaactggggc aggtcttttg tctctgtctg tatgttaaat 27660 gagtattata atttttactt ggcaagattg ctgtgaggct taattaaagt ttataaagtg 27720 ctttgggagc ctgagagatg aagctctaaa aacataatat gttattatct catcctggat 27780 ttttgttttt agatttactt gcttgaatct gtatcataac gatgcttaca attcaggcag 27840 ttttctgagg ttttttattt ctacaaagac atgaaataaa ataacataaa tatataagtc 27900 cctagacatt catatgggat gaaaaaatta cacataattt ttttctgatg taaaagagtt 27960 tcttcttaaa aaatgtttaa ttgaatctta tatctgttaa ccagctttat ttttttaaaa 28020 gcatttcagt gttttattcg taacattttt gcagaaccag taaaaagttt taaaatgcag 28080 tcatctttac tgggtcatga gaagaaaaat ttactccatt taaaaaatgt aaatacttat 28140 ttaaatgtaa ataaatatgc gcatttagat atatataaat ataaatatat tactccaatt 28200 gaataacaat ggaattaatt tacagtaatt agaatttgat aatttgggct tgaaagatat 28260 tcctttcttc tatctttctg ccttactttt ttcttctact gtgtgttcat ttgagatttt 28320 catatttata aaatataaaa atgtatatag agccctggag ttaatataaa ttgccttgaa 28380 aattcttttt attcctactt tgtattcttg aaagaaaaat catgttttcc cataagaaca 28440 gtgtcataat tatggataaa atttctgacc aagctattgt catcaagtaa gtaatagata 28500 tgtttaactc tatgtcataa aagcaaagct attaccacca taagccagta taattattgg 28560 aaataacaaa atgattctca ttgtcatata aactttgctt aaatatttta tatgccttga 28620 catatatgta ttaagtttac ttataaaatg ttatttttat aaacttatct agaactgact 28680 gctattataa taaatacttt taacattttg acatgccata attttgatcc atttcatggg 28740 gaataatttg agaagcctat gtttctcaaa attttcgtag gaaaattaga atggatactt 28800 gtataatata ttcctgttac taggaatgat gcttaaaaaa attctatagt gtaggtcagt 28860 cttcatttta agcaattgaa tccattttta atgatattac ttaagaattt tgcttgtaag 28920 aaaaaaaact gtatctgatt gaatttgaaa atgtagtttt ggagtgtatt tactcttcct 28980 gcctgatacc ccactcccca aaacagagta gtcttgagga aataaaaggt cctcaaaggc 29040 agctagatat gagaagagtt tgaattgcta atggggaaac ttctagacct ttgccttgat 29100 gttagaaaag gaatttgaga acatgattta tgtgttagac ccagagtttg tctttaaaca 29160 caattcaagt ttatcacctt tcttataacc tttctataca aaaccatgga tttagtgaat 29220 aaagcatttg gaagacggtg gatagttgat agataaagca gattgaccaa catgtaaaaa 29280 tagaaagtgt tttcatagta ggaatttgga ataacttttt ctatattccc atagttagaa 29340 tggatgccta gaaaatgtat ccttattgtg atgattaaaa atctcttttt gaactaagac 29400 acgtaagata gtaacctctt tctgctttgc ttattctccc acccaggctg tgttgaagtt 29460 atataagtat aagcaaatgt gcactttttt tttaaatttt attattatta tactttaagt 29520 tctagggtac atgtgcacaa tgtgcaggtt tgttacatat gtatacgtgt gccatgttgg 29580 tgtgctgcac ccattaactt gtcatttagc attaggtata tctcctaatg ctatccctcc 29640 ccccttccct caccccacaa cagtccccag tgtgtgatgt tccccttcct gtgtccaggt 29700 gttctcattg ttcaattcct acctatgagt gagaacatgc ggtgtttaca ctgttttata 29760 aaatgctttt gtctaatttt gttaccttta agtttagcta cttggcaaat aaacattttt 29820 aatactgctt aagtcaagtc ttttacaaat agaattgtca acatccaaga gttaccaaaa 29880 gatacttcat tctttagatt tttattgttc tttcacagta ctcactggta atggattata 29940 ttttaccttt tttttttttt tttttttttg agacagtctc tcactctgtc actcaggctg 30000 gagtgcagtg gtgccacctg agctcactgc aacctccccc tcccaggttc aagcaactct 30060 ctgcctcagc ctcctgaaca gctgggatta caggcgcgtg actccatgcc cagctaattt 30120 ttgtattttt agtagagatg gagtttcacc atcttggcca ggctggtctt gaactcctga 30180 ccttgtgatc cacccgcctc ggcctcccaa agtgctggga ttacaggcat gagccaccac 30240 gcccagccct attttacttt tatctattgt caatgactac attgaatact tttgtatgca 30300 aatgtaacaa aggcatattt tgcagttatt tatactttat gtctgagaat tatcacataa 30360 tttagcaaac attaactcat ctgtttacct tttgctgtaa aagctagagc aagtgatgta 30420 gatggggaca agaaaatgac tcactcagcc tcagaaccac aaggaactat agacttcttg 30480 cagtctggtt ttctcttcaa aaagcaatta aatatacgac catttgtata agtttccaca 30540 atgcattcat atttcagaac tgatttctta cctagcacgg catggatttc agttataatg 30600 tttctccttg cacaagcatg gtagacatgg ggttagtagg tataagaatg cctctgggaa 30660 caatctttta aggttttata gactcttttc tctcaccact cccccaacct aagtgtaatt 30720 gtcatcttag acactttgag tttaggggtg gagataggga gagcatcatc agaagggaca 30780 aaaggagaaa ggggaagtga aatggtttgt tggatactag tgagtggagc cttttacaga 30840 agtacaatgc acgcatttta catttgttag ttagatgttt tctaagatgg ttttgtagct 30900 ctgatggtat atttttatgg atataaactt ctaatatgag gaagagaccc aaaccaattc 30960 aaatagcatg ttaaaattca atctatctac aatcttcacg tccttgatta ttacattctg 31020 taatctcatg ggtatttttg cttccaaata taaggacata cctattattt ccttcagttt 31080 tctttttagg agagttgact gaactatttc aggaaagaag atgtcttact ttcctttgcc 31140 tagtaagcct tgctgctttt tgaacacagt gcattttctt caaaatatac ccactacttt 31200 aggtggtctt aatgaatgaa taatatgtaa ttgtgtatac ttttctaaaa ttctttgaaa 31260 cttccaggaa ggaaggtctc attaaatatc tatttgaatt ttagtgaaaa gaacaaaaaa 31320 aagcaataac aaattaagac ctttgattca tgtgtactag cagtggtttt attttggtag 31380 ctagtgctgt gatgtaattg aagcagtatt ttcatataga agcatttttt acttttatgt 31440 tctttctact tgttagaagt attcttttat tatggttact tttgaatgta tgtttccctt 31500 gcactaactc agaatacagc ctcacttcac agcgcttaga tttgattcct gcattcatac 31560 tgtttgcatt tgagggtcct ggtgactgca gtaatctcca cctcctccag agccagagag 31620 aaagaaatgg ccacagctac tttgtcatct tttgtcactg gtctcaatag agggtcaagc 31680 gtgcttacca catggaggat gcttcagaac aacaagggaa agaattagag tgttgcctgg 31740 gtactgccca cgctgctata tgaacagtga gagaggttat attttcctaa gcctcgctta 31800 aagcattccc aactaacaga ttttctgttt ctaatggttt gaacttttgt ttttaagttg 31860 ttatttgggc atgtggttgt agggcataga ttatctccta atttattgct ttcttaattt 31920 gacattggaa tttagacttc agaaacaaaa aatgcaatac tttgaattat cttctttcca 31980 taagttcctg atttaaaatg aaaatgtccc cttaactgct aattacgaga tatcgtataa 32040 agcatatgat acttacagta tatctttttt ggttgtttta taagatgaag attacaaata 32100 tgatatttag cacatcctgg ctcttcttga aagcagggac tatggctctt ttactaaagg 32160 acaaatagtg cctaaggaaa caggagggtg taggagaaag aattcagctt tgtggtcaga 32220 tagacctggg gggttgaatt tcacttctct ctagctgtat ggtgttgggc taaacactgt 32280 ctctagagcg gcttcctcac ctttcaaata gggatgatac tcctttaggt aacgatgtta 32340 ttggtaggat ttgatataat aagtataaag tgcctaaaac aatgcctgta aatggtaatt 32400 tctattagga tggatcatag atttaggatt agaatttaca ctaaacctac cttattcata 32460 gatttgtcca gaatcatagc aggaaatcta ctccataaag tagctctagc ctctggtgcc 32520 tagtagaggt gatgtattag gatagtactt taaaactttt accccaatta agagcagagg 32580 aaaatgaatg gctagattag ccatcctgag ggtttaatct gaaatggtcc atagaagaca 32640 tatcattttc tttctgaaaa acttatttca actttgcatt caaatataaa tatatatttc 32700 aatataggta tttcttcccc tcattaaaaa gtctttaaaa ttgttgttcc aggaagatga 32760 gtagtattta tcttgtaaca ttgagttatt atacccaggc gcactaccag gaacacttct 32820 gatgtacaag tgccttcaat aattgtttca gaagcacaat tttgagataa gttaaagtgc 32880 cctgggaaag agcattgttt atttttggag ccttagccca aaatgactcg gactcatgct 32940 acaaaatgat aacgctcttc atcagttgta tagagctcct tctttatggc cagctttcct 33000 agagatattt tagacttctt tagatgtccc caaaggcaca ataaccacgt aagaagggaa 33060 gccacaggaa ggcagattgc agcagaaaat gaatggtcag ggttctctag gggtggctgc 33120 actgcctcca gtggtggtga gttctccacc tccagagagt gagacaccct tgactcaagt 33180 tttagatgag agaaacaatc aagcagcctc tgaagttccc cttgaattca aattctttgc 33240 atccagaaga gaagtatttt gtgaccagaa agatacagat tgactgcaat tgaccttttc 33300 tatgccagac cattggttaa ctgaagagag tagactctcc agacaggcag tggactcagc 33360 ctacaccaaa acacacagca agccttctgt gcctttcccc aggacagtga ctcttctttt 33420 ctctctgaag ctgtggttct atgtaggaaa ctacataggg tgaagctaaa aggtaggatg 33480 ggccagccta tgtagggtaa ggctttttaa ctctatcgca tgggcagtgt gctgacattg 33540 catacttttt cagcacctct tcagatcggt atataaagta gattaacctg acagcagatg 33600 gcggttggtt ggaggggcct gcagtaaagg agagcagttt ggagaatgcc acggcatgca 33660 gacgcacact gtggagctga gcactcagtc ggtgatgtgg ctcactcacc aggggaagga 33720 cagaggtgag atagggcaag agtcagttgc tgaagtcact actccaaagg gctagataga 33780 aaggtaggga ggaggaatgg agagccagaa aaggagccaa aatgattagc tattttacta 33840 gagcaggtct gtcctaaagg cttggctgcc attctctagc tgggaccttg acgaatcact 33900 tcctccctag tgcctcagtt ttcttgtctt caaaatgagg atgatgctac ctatcctgaa 33960 gggttattgt gaggattaaa tgagatgatg gggtgaaagt gatttgtaaa ctaggaagtc 34020 tatcatgcaa accgcatgat agacttcgga tagaggcagc aggtatacct ttcagctttc 34080 tgtcttgcca aatgaacatt tgtatcctct cacctggtgt ccaagatgaa ggtgctggtt 34140 cagtgagata actcttatcc agcctaatct caagacttcc tttcatgctc tctctctcac 34200 acctagcaat aaatgccaaa agcctaatag ccccccaaac cttgatcgtt tcaagaggat 34260 cctttcaaag gaaacctgcc tttcctctct ccttgaggag aaaccaaagc agtccagtga 34320 ataaaattca tatttttctc ccaggctgat tgaaatggct ggccgtggga gcccagggcc 34380 tttttgtagg actgttttat ttatttattt tattattatt attatttttt ttttgagaca 34440 gagtctcgct ccgtcaccca ggctggagtg cagtggcaca atcttggctc actgcaacct 34500 ctgcctcctg ggttcgagcc attccggatt cgagccattc tcctgcctca gcctccccag 34560 tagctaggac tacaggtgcc tgccaccatg cctggctaat ttttgtattt ttagtagagt 34620 tggggtttca ccatgttggc caggctggtc ttgaactcct gacctcaggt gatccacctg 34680 cctcagcctc ccaaagtgct gggattacag gagtgagcca ccgtgcctag cctggacttt 34740 tccaattagg ctgtgccggg gctgctgtga aactgttttc ctgtgaagac agtgattttc 34800 tccttagggt ggctgctgtc acacggcact gcccctttcc ttataatact tgatcacaga 34860 cacagtaaca tctgtgccta gatcacaagc catacttact caggacgatt ttcctcttaa 34920 agcaccaggg agggagaggc ccttgtcaga attctcacga ctgaatcatt gccatgagct 34980 aatgtctcca gttttatgag tcagtgctgg cccaggcatc ggttttgtag gtttaaaaaa 35040 aaaaaaaaaa agacatgggt tagactcccc taatatcagt agcttgttca gggggaaagc 35100 aaactgagct atcatcagac agcagcattt tagaaatcag atgtttggtt cctctcctct 35160 gtaaggatat agaataagtg gaagaatttc agaattaaaa ataatagtaa taaaagctct 35220 ctgatttgtg cgtgtgtttt gttttgcttc tggcaaagaa ggtaaaatgg tgtgtttggg 35280 agatgaatgt tcttgtaata ggcaagatgt agcttgcagg agaacatctg caacaaaccc 35340 ttattctgca tgagatacag ccaagacctg tttgtgtgtt agtgcctgtt caaacatgtc 35400 taatttttaa aatgatttat aaagttttgg aggaatcacc ttaaaatgtt atttcctcat 35460 ataataggca tatacattca cagcgtggtg gctaaactat acaccctgtt ggagtttgag 35520 cagtgccaat attgagctaa gtgatataaa aatggttatc aatatgaagt agatagaaaa 35580 gtattaggaa tatctgcaat cattcgtgag tctaccgatt aatccagcag caggcaaaaa 35640 taaattatgc tttccacgtt tttaaatgtt cttggtagag aatttatgca aagaataaaa 35700 gggaaataca tggatatttg cttcaaaata cccagaggta ttgctcaaaa cttgattaaa 35760 aataaaataa cagaattggg gatggacgtc aataagaaag aataagctta aataatatca 35820 gtatctatta aacaacatga tttttaattg tgtcttctct attctttccc tttatcatat 35880 atttacacat aataggaaat gccttttagg aaagatagtg gaagccttct cttttgtttt 35940 taacagccat tgcttatgta gtgctaatgc atcttcttaa atccacgtgc tttaaaaaaa 36000 ataatatttt atggtagtca tgtacttctc aacacatcat ttggaaagaa agttaggggt 36060 atgcgctgta atttgtaccc agtattcaga gtttacaaga aagattgctc ttccctgcag 36120 cctctccacc cttccccctc cttctctctc tcccccactt gcttcttgct ccttgtttct 36180 ttctctgaag aaggacgtga gctacatgga ggacagggca gaaaagggaa gaaaaaaata 36240 ggaaatggtg agaaaaatat taaggacatt taaaacttaa agttttatgg ttctttttag 36300 ctaaatgaat cttttgagct tccatggggg aaattagtgt aattaaaatt ttctagttca 36360 taaaaccaaa tctttacata ctgactgagc ccactgtaag tattgactaa ggcaaggaca 36420 aatgttatcc tctgacttgg aaaattcaaa agaagcattt tgtctcttaa atgaaggtag 36480 gttgattata tttgatgagc ttcttggaaa aggcattgat tagtccacat ccagaaattt 36540 aacttccctt ttgcttatac tacttgaaaa atgattttat ggacaccgtg atgtaaacaa 36600 tgagtctctc taggaaggga tactgtgtat attttttgtt ttatttttaa ctttctggca 36660 ttccaagaca catacagttt ttatttgagg gaaatattcg taaaatagaa tacgaaggaa 36720 ctattccaaa gtcaggagtt gagtgaaata tcccaattaa aaaactgaaa ggattgttta 36780 tcagtaagtt gcaggatatg tgtagagctc cacaacatga aaattcagta ttaataattt 36840 tggcttgaaa tattttcagt tctatctcct tataagcttc agaattacta accaccgaaa 36900 ctggtgtaac taagaggacg catagcatga gtctcatagg atctctccaa ctggtgcctt 36960 gtaattttgt atggtatgca tgtgcacaca tgtcccaaga tgcgtttgtt gaggcttagt 37020 tgaaggcccc atactatgag gtctcaaatg ttagagttca ctgaacagca cctttagttt 37080 caacatgcat tttctaagca ctggaaggta cacattgaag aaaaacagat ataactccac 37140 agttgactag ctgggttgac taggcaagtg acctgatgct tctgagactc aattttctct 37200 tctgtgaggt gaaaataatc tccattgaag gcttttgaaa gttcaatata tgaagcccat 37260 aatatagttc ctgccactga gcagggcctt gataaattgt gctagttatt attaaggcta 37320 gacactattg ggtaattata ttaatagata agttagccct ttctcaaaga gctcacagtc 37380 aagaagggca aactgataaa cctagttgta atttagtgtg acaggtgcta taatctgtct 37440 ggaatgttcc cctagccacc accacctctg tctgccatgc agactcctac ttattcttta 37500 aaactcattg gaagcattaa ttgtagatga acacttgcct tgtgataccc accccccacc 37560 agctccccct tacagacacg tactcaggag ttcagaggca gtagctttga cctttcatct 37620 ctgggtctta gtgctggcac atataatggg tcttaacaaa tatttttcag gtaataccta 37680 ttacctaaac aaagtggaat gtagtacaga aaactgattt tgctagtttc acagaaaact 37740 ttgcatttaa agttgggcct tcaaggataa gcaaagtctt gggaaaaata agaatagata 37800 ttccaggtag agggaccagg gtaagtaaag gcatggagac atgaatgtgt tatgtaagtc 37860 taggagtggg aagcagtttg gtatacctgg accatagaaa gtttgcagga acaggagtag 37920 caggaaatga ggctagagag aagtccacag agccagattg agatgggctg tgaataccac 37980 cctaaggagt ttggctctag tcctgcaagt gttaagaaaa catggaaggg ctgtgagttg 38040 ggagatgaca tcatgttctg ttggaggaag ctaactggca gcagtttgga ggtagggaga 38100 ctaaaagcag ggaggctaat tggaaaggtg ttgcaatatt ttagataaga gatatggggg 38160 ccaggtgcaa tggctcatgc ctgtaatccc agcactttgg gaggccgagg ctggtggatc 38220 acctgaggtc tggagttcaa gaccagcctg gctgatatga tgaaaccctt tctctactaa 38280 aaatacaaaa attagctggg ctaggtggtg ggcgcctgta gtcccagcta ctcgggaagc 38340 cgaggcagga taattgcttg aacccaggag gcagaggttg cagtgagctg agatcgtgcc 38400 gctgtgctcc agcctgggca acagagcgag actccatctc aaaacaagca aaaaaaaaaa 38460 aaagagagag agatacggag atatgggcag gcaaagggga aaggaggtga gtgtggggtt 38520 tggggtggtt ttgcagtata tattttagag atagaaacct attttccgta attgggatta 38580 ttttgactcc taccattgta acattttcta gacattggtt ttagaggtac ttcttataag 38640 gactgtacca agaaactagt tgaatgatat attcctcaag gtttggggcc tttttggtgc 38700 catgctttgc tttctttagt taggattagt cttggctatt tatccttctg ctttgactat 38760 gagaagaacc acatacctgt aattggtcag acaaaagaac attttatatt ctctatgtct 38820 ctgccttgca ctagaaatgt ttgggtaaaa aatttattgg tttaagaagg aagaaatgtg 38880 cccaaatagc caatgattgg cttgatggct ttggctaggc cgttttgctg ctttgagctt 38940 cagttttctt atctgtaaaa gaaacatatt gagctaaatc ttgatatctt tttcctattt 39000 cttaacgtgg tatggaagtt aacactttcg tccttttact gaatgaaaat aatctaatag 39060 tagcttaaag aaaacggaag catctttcac ttcagtgttt tgagcgtaat gaaatgaatg 39120 ctattattat aaatagcagt accattttac aaaatcagaa gctaggaaaa tgtatttggc 39180 ctttgactcg tggttggtcc tcagtgaatg ttcagtgaat agaattataa aatctctttg 39240 ttcttttttg ctgagtacta aagaccataa atttattaca gatgatattt actgataata 39300 aagtactttt atttttactg gtacccaaag aaggattcaa aaatcttggc agataccata 39360 ttaccaaatc taactatagg agctggacca agagagaaga ctctgtaaat cacctgtcta 39420 cagacccaag acccaaccat cttaaaagag gattcaggaa atcatttaaa tgtttcttcc 39480 tgctttcatg ccttgaacat gctgtttctg agcaatacac tacagagatt gccctaattg 39540 acactaaata tgagttttaa gcatttattc tgaaaactag acccatgtaa acaagttagc 39600 atccaactat caattcttag aaaatctact ttccctatat gtctactgga ttatttgtct 39660 cagatcttag gggaggaagt ggaagagctg gagaacagca cgtgttattt tagagttata 39720 actggaagta tttggaatgg cttctatgaa agtttatttc actgaaaatg tggaaacagc 39780 tttggaacta aggaatgggc agagactaga tttggaggag cagggtacta aaagcctaga 39840 gtctggcgag gacttagaag agaaaaagat tctggaaagt ttggagctct taaagaaaaa 39900 taaaaattta cttcacttct aactatttgg ttggtgcaaa aataattgca ggttttgcca 39960 ttactttttc accaactaac aaattcagtt tcaaagattt ctatactgct gacagttttt 40020 ttcaaatatt agccctttta attatttcat taccagacca atataacctt aatttttttc 40080 aaccaagata aacaattttt ctgcagtaaa tttgtattta tgttccagac acatctcatc 40140 tgatatacaa tattttctta aattgtataa agagaaatta ttgtacatcg gatgagctgt 40200 gtctgggatt aagtattagc tccactgtaa ccttcatttt cttgaacact ggaaagaaag 40260 gccaacggtc atttagtagg gttggaatag gatggggaat ggggctttgg tgagagagca 40320 ttggactgtt ggttatagaa acacagttca agtatatctg gagttcagat ttgagatctg 40380 actaggagaa tctgtctagt gaaaaaagct agacctttac aaattgtagt caggagctac 40440 cgttgtaaca gtctgccaga gttcctgata caaaagattg ataatttgtg tgtttgaaaa 40500 acaaaacaaa acaaaacaca tctaccttca atttgactta ctgcaactct gattttcatg 40560 gcaagggata gagacaaaat tcattctata aaatttgaaa aaaaatgtat atcctgaaac 40620 cattggaaat tggatatcag cattaatttt attggactga aaaacctcca gtttactaac 40680 aggagttgaa agtcatcact tttcctttca tcatagtgag ttttcatcac aaaccacaat 40740 gatatgctta tctcaaatat attcatttac ttgttttaca caagtatcat ttctgtttac 40800 ataacacgca attttgttgc tgctgctgtt gttttattat gcctgtcact tgagtaaaag 40860 atggataagg taaggtctcc atttagaaat gtatagtctc ttggcaggga agacaaataa 40920 aggcccataa ttatcataac agaaaaatta atatgtgacg caagaaaaaa taaagatact 40980 attaaatttc tttgggactt tgaaggagga agggagcata tagacactta gtaaatattg 41040 tttgaagaag ggaatgaata tgtaaaggga gaataaacct cacctataag gtctagggca 41100 atttaaacac aaaggagttg tgtaggatta tttaaggttt gcaaatgtgt aaaattatct 41160 cactacaata ctagggaaat ggaaaaacac caaagttcct ctaccagctt ttgctggatg 41220 agatgggcca gaagtagtaa ctgcgagggc agcctgtatt tctgttgttg gtgtggttta 41280 tcttcccagt gccaatgctg ccaacttccc ctcaaataaa aacccatagg ggttcagagt 41340 ctcatgaggt gagaacagac ttgcactatc tgtgacaaca acaaaagcac ttataatttt 41400 gatgtggagg atcctaattg aaatctgctg tttgaggttc cttgggtcct gcattctttc 41460 ttaaatattt ctacttgagt tggttattga tccttattta ttttccgtct aatcgattga 41520 ctttataaat ctattgcaga gggcagatta aataggcaga cagttttcta atttgctgtg 41580 agggtatttc ttaatttact ttttaaatac tgattttatt tatacattta tatgcacagg 41640 tcattttcat ttccatgata tcattcgagc ttcacaacca cactccaagt tcagtgttgt 41700 tatcttcatc ttcatgttga ggatgaggac acggaagctc acaggtaaag tgacaaaccc 41760 cagtctttag gctactagat ggtggagttc agactctgat tttctggcca ggtgctcatt 41820 tgatgatagc agcatgaagc tcttcccatt ctgcaccgtt tgagctccta cccttcctaa 41880 tcttctttct ctaatacgag aacactgtaa ttaaagtggt atttggctga taagtagtag 41940 gttttgattt ataacacata gagctggcag tgtaattttt gtcccagaac ttgatgtgcc 42000 atgaaagcta ttatgctctt tttttttttt tttttttttt tttttttgag acggagtctc 42060 actctgtcac ccaggctgga gggcggtggc gtgatatctc ggctcactgc aacctccgcc 42120 tccagggttc aagtgattct cctgccccaa cctcctgagt agctgggatt ataggcatgc 42180 accaccactc ccgcctaatt tttgtatttg tagtagagac agggtttcac catgttggtc 42240 aggctggtct tgaacgcctg acctcatcat ccacctgcct tggcctccca aagtgctagg 42300 attacaggca tgatccacca cgcccagcac tataatgctt ttaatagagg gaaatgaatc 42360 ttcagatgat gtcagcatcc taattttttt tctcctcttg gggtttttct aaatgactgg 42420 caaatggaaa acctgaaagt tacctgagac ttctctgcat cgggcttgtt ggggtatact 42480 gttcttctta taatcaaccc cagggactga cagatggaca gttgttagag acaaagtcct 42540 caatccaagg aggtcactca gggccaactt tccttagtat atatcgttca ttacattagt 42600 tggttatatt acctgtagta caactcaagt acaatagctg caggaggaga cagctcgcca 42660 gctaaaccta aaagttacaa cagtgacata gcaagcaagg gtaaaataaa aggctcttga 42720 cttattcctt cattttttaa taaagcatga agtttgacat aaattttaac ctctggccgc 42780 atagtcagtt atgcttatta tcttgtgtgt attattatgc tgtcaggagt tggccactga 42840 tgaccaactc caaaatttag atgatagaga taaaactggt agttaatata tgttgagtac 42900 caggtcaaaa actccataag acactttaca ctgtgggaac tggttcatgt aacagttctc 42960 caggatggag gattaatatt cccatttcac agatgcagag ttatgtgtct ttctagacct 43020 gacaacacct gtcacctacc aaatgaatag agagctatgc tataagtcta gggatgagtg 43080 atccttggat gcagagcact tcctactagt attctgactt ttactattat gcgtctgtta 43140 ctatttgaca gctctcattt ttgcctgtcc aaatttaagc acgtttaatg agataaagag 43200 agcagaggca aaggtgagac tggatcttcc cttgtatctt attgatagag agtaaatcga 43260 atccaatttg ctaaggcctt ctctctcctt tcatgtttcc tcactttgcc tccaccacca 43320 tgaggttgaa aaatgagttt ccatttagtt taagcctttt gttattcatt acttaatttt 43380 gcttctattt ccctcttcta tctatgacaa attcagcaca gtgaggggaa gaaacagtga 43440 tgatagtgat ggcctcaaga agaaaacagg gtgactgagt aggagcaaat aagtatctca 43500 gaccagcata taaacaagtt catttgtagt gtaaaagaac attatgcctt tggcttgaaa 43560 actgcctttc caatttatga gcatgtttag gattatgtaa gtacagtgtc ttcataacaa 43620 gcccaacacc tcttacccaa agaatgcaaa acgctttgca aacagtagaa ctcacaattc 43680 ccctgtgacc tggggactta tatgtatttt catgcattat tttttataga ttgagaagtg 43740 aacttgagac ctaccaatct gtccacgttg acaaaataga tccaatacta aactcttaat 43800 tccagcttcc tgtcttctta gaagcagatc acactgaaag aggaatctta tgtcaagggt 43860 agcaattttc tctctctctt tttttttttt ttaaagaaaa cacaaattac atagtagata 43920 tatttgcata aaggtagatc ttgaaaacat ttaattaaga cagcggtatc tatttccagg 43980 aaaaaataga aaagccagat ctctactcca ctgaatttaa aaattagagc agcattttgc 44040 agttaaaaac gattattatt ttgcattctg ccatttgtct ttacatgaag aatgcctgaa 44100 ttcagaatgg aaaatatttt cttttgaaaa gtgcatagga aagaattgtt ataaagcaaa 44160 tgtgttcaga atgtatgtag atattaatta taagtaaaag taaaagaagt aggatgtatg 44220 tgagcgtatg tgcatttgtg ttgcagataa accgattttg aaggttgaga gacatgacga 44280 tacttgttag gtatgaggga gacaagacca gaggcgccgg gaagcttgac taccgtggag 44340 agctcagttg agacttgtct ttgcccatgg cctgcagcgc ttatgtagaa attggggatg 44400 cttttactcg ttccaaagcc taacctgatc agacctgccc aggttggagt ttgggaaaaa 44460 aagtgtttga agtaaacagg aaaattactc accttaatga tgtgtcttac tggcactgac 44520 agtgctttga tagtctgaca gtcttttttt ttaagttttg ggaggaaaga caggggaaat 44580 tattaatatg atttttggaa aacatagatt cttatgctta tgcacttgct aataaggtgg 44640 aaaaagtggg ctttgcacca tttacagtta tggactcgcg tttcctccta ataaagtcta 44700 tatcaggaat tttccattag gaatttctac caaaaagaaa agaaaatacg ttactgttta 44760 ttttgtgtac ttgtgccatg tatctccaca attgcgctgt ggctgttcac acagaacaga 44820 ttcttcctag cacttgggct gtgggttccc aaacttgcag gtcgctttca tctgtctggt 44880 gattaagacc ataaaccaag tggtgtgatg agagagtttg gtgctctaga cagagcaagc 44940 acaccctttt ttcataagaa gcacaattct taaatctctg cacctaaatc tttccttagg 45000 atgggtcagt tttttggaaa aagcaattat atatgttttg atattttgtt gaaacataat 45060 agatgttgat ttcatatggt ttttttcctt tttttttttt tgtctttgct aaatgtcaaa 45120 cggtacattt tttctaagct tgaagacaga gaactgggtc atatgtctct aaacatttaa 45180 atcttcactg agatagggaa gagtgacctg atcttatgga tcgtccgagt cctgtgagac 45240 aaaaatgctg ggtttttcat gcagtcccta attcactttg accttggtgg agggagtcaa 45300 atctcctagt ttgagatccc acacatataa agctctagag tttcaggatt aaaatcttct 45360 taactttata ttctcagatt ctgtatagct tattaaacta gatggagggt ctagttatac 45420 tgtctagaag gacatagatg aatagttata ttttataaaa attaaactcc taatgataaa 45480 aggctaaatg gggagagaat aaattatagt ttatgaaggc atgtaaaaca aaagatgtct 45540 gccaatttcc tctctttggt tctctgactg ggaataactg tatcgttttt actttttttg 45600 tcctaactgt gtcctaattg taaatgaatc tggtgcccag taaaatcaaa tgaatagaaa 45660 tacttaccat ggtgtgtata taccagcctc ctggtgtctc agatataatt aacataatga 45720 aagcattgca atacattctt accgaaggct cagttcctgt cctgtcagca actgtttgcc 45780 tacaactaaa gcaagtctgg gttcaaagca ttttaaaatg ttccaaaaaa gtggggaagg 45840 cggctgggtg cagtggctca cacctgtaat cccagcactt tgggagaccg aggcaggtgg 45900 tcaggagttc gagaacagcc tggccaacat agtgaaaccc catctctact aaaaatacaa 45960 aaaattaact ggccatggtg gcaggtgcct gtaatcccag ctacttagga ggctgaggta 46020 ggagaatcac ttgaactcag gaggcagagg ttgcagtgag ccaagatcgt gccattgcac 46080 tccagcctgg gccacagtgc gagactccat ctcaaaataa taataataat aataataata 46140 ataataataa taataataat aataataatg taaagtgggg aaggcaagat ttggctcacg 46200 cgtcagactt cctatcaatg ggtctatctt tgaagcaagt gctcagagtg tctattcctt 46260 tgatcacacg ggtagtggtt tatttccatg agtatttgct gttttcagga gatttcactt 46320 tgggttttgt ccatattcca cattcaggaa actgttaatt ttggaagaag agattgtttt 46380 tacttggttc ttctaaggaa attaatcaaa tgtacacgtg caacttaaaa tcaaagaatc 46440 cctgttttaa gaggagtttt tcttatttca actggcaaac aatatgaaac tgaatgtacc 46500 caaagtgttg gaggtttaca aacatgatca gcacttgtta atgacaattt tctcctaaga 46560 aaatggaatg ctaccttcta gcatggggac ttgtaggcag tatttctgtg tttgctagcc 46620 ttggaaagta taactcttat agggttgggc aaagcaaagc gtttttgctt tgtaacctgt 46680 agaaatgatt acgtagtgta atttggttat ttaatataat ttgttaataa ttctcattca 46740 tctaccagaa acttaaaact tggtactatc ctgctaattt ggttttggta atgtctcttt 46800 tccctaattt taatatccct gttccttggc aaacccatcc atacacctac ctgttgttca 46860 actggtgtga taagccccat cagtgctcct agacattttc ttttcctact cttcctcttc 46920 agtgtcaggc agaaggatct ttctaacact cgcctcagtt catggattgc tgatggtcca 46980 ttgttggtga ctgcatgatg acctgtaagc atgtcacact ctgaccaaag tgtttgtatt 47040 tggcccaatt ccccacggct aataataatc cctttctgtt tggaaaatgt cttatatttt 47100 tcaaaacaca cacatatatg tattatcaca tttaatcctc ataacaaacc tgtcacattg 47160 gcaggtgtta ttctcacttc tcacatgcaa agttatgtaa cctttcttga gattatacct 47220 cagtttggaa agtaggggaa tgagccttct gcctctgtga gtaccgtgtt cttcacggtg 47280 tacgatgctt ccaaatatat actcttccca acaggcagag gtggtgtttc gcagtcaaca 47340 aaagatgatt tttgttttgt tttcccttct gcatgccctg tctcctgcta cttcctctgt 47400 tcaaaacatt ttttttttct ctctctctct ctcctctcac tgctgcctac caaaattatg 47460 tcacataatt tggctattta atgtaatttg gttaataatc ctcatctatc taccagaaac 47520 ttaagagttg ttatcatcct ggcaatctac cttgaagatt ggcaaaatgt tagttaacta 47580 ttgaatatag atgatgagca tatggaatta aatttgaaat ttccaatttc aggttccaaa 47640 aatccaattt caaattaaga aattttaaat ttaaatctta aattaagaaa tttaagaaac 47700 ttcttaaaat ttttacttat cctttctagc tagagttgcc agatttagca aataaaaacc 47760 aaggatgtca gttaaatgtg aatttcaaat aaaccatgaa aaaatgttta gcataaggga 47820 atcccatgca atagttatta cttttgtttt attttgtttt gttttcttga gacagagtct 47880 ccttctgtca cccaggctga agtgcagtgg tgcaatcatg gctcactgtg gccactacct 47940 ctcaggctca atcagtcctc ccacttcagc ttcctgatgg ctaatttatg tatttttttt 48000 ttctttaggg acaggggttt tgccatgttt cccaggctgg tctggaactc ctgggcttaa 48060 gcaatcctcc cgtcttggcc tcccaaagtg ctgggactac atgcatgagc cattgtgcct 48120 ggccaatatt ccttacttat gctgaaaaat ttcattgctt ttacaattaa attttaatta 48180 ggctggagat tatctggtaa ccccattccc agctcaatca ccaactctct aagcagaagg 48240 aaatttttca tctctcttgc catagtgagg tcaggattag tgaggtgaca agattaaata 48300 tgagctaagc tatgacactt gttttccaca gtttcctgag cccccctccc tccttttctc 48360 tttcttcctt cttacctccc ttcctctctc ctatttattc ttcctacctt tttgttgttg 48420 ctgtgagtgt cttcacctgt ttccttcctt cctttatatt cctggtaatg tttcaaattt 48480 attggcatgg gcagcttctc ataataggtt tgtttttatt atttttcttg ttattactaa 48540 aacatgttaa tagatagatt ctaactctat ggcacaacta agacagttgt gttacattct 48600 tttccgtgtt ggggctaatt agaatattaa gtttacaaag aatgcagaaa aagcgaacaa 48660 gatgaagcac gtttccgtct taaacaaatg aactctaaag aaataggaag taacatgatg 48720 acaagctttt aagagatgtt gcaagtagag gaaagggttt gtttaaatct ctccccaagc 48780 accccctaca cctaccccca gccaacacag atgcttatgt attagtggcc cacacggtac 48840 ctaattatca acgatggaaa tagatgtctc aaaattgttt caattatcca ggggttccct 48900 taaaaaagga gaggagagca aaagtttaaa acttggcttg aaggtattaa agagcaaatc 48960 tgatctaatt gattaagtta cacctttcct ttttggcagt atcttaatac ccctaggatc 49020 tcagtatttc agcatattgg tttcctgtac ttatctagaa taaagaaact cagcaatttg 49080 cctataggat agtagagcct tgaactaaat ttatctcatt attgttcact tgaaaccttg 49140 gggacagctg tagttgaagg gaccttaaag tcccttaaac ttctcagcat ttgcaggttc 49200 acttttaagg tgcactaaaa agcaactagt atcctaagct aaaaaaaaaa aaaaaaaaaa 49260 aaaagaaaaa gaaaaagtag atttaagtat accaatgagc atggactctg tttatgtttt 49320 gaaatccatt tgctactcat tttcctcgtt tttaaatcct attatattta cacctgggca 49380 tccatttctc tgaagagaga agaatgaagg atctaaaatg tcagaataac agtgattctc 49440 aacaattatt gtcggcactc tttcatgaag agatttaaag ctctttgctt atctgactta 49500 attcctgccg gaaggacagt acagagggat tacggtttaa atattgcagt tagaagcaca 49560 aagtggaacc tggacttccc cgaccttgga agaaaaatag taaagtgtgg ttcctataaa 49620 atattatagg aacttcagac atagaatgga gcatccattt atagtgattt aagttccagt 49680 attgaaacag gccttctatt tttatttcaa tctccctccc ctttattttc tttgttttgt 49740 gattcacccc aaaacgtatc ttcttatacg gtaatattaa ctagtacctt agtcaaagat 49800 tgatctccag aagtttgttt aggaaattcc ttgtgttact tgtctagcag ttaaactgcc 49860 tagtggaaac aacagctcag ctaaatagtg tgatgcaatc gtgatagctg ctgttcatca 49920 ggcatttacc ctggaccaag cactgtaccc tgaatatcat gtggcttttt ctccacactc 49980 aggacaagct tgcagtgggc agtagtatta tctcagcctt gaaatgagtc acacaaggtt 50040 ttgcagcaga gagaactgtc ctctttttca gccctgtaca ggggaggagc aagggtgctg 50100 cagtgagggg atctggagtt gaatctggct tagtagctgt gaaagattgg gcaacttatt 50160 tcacgtttag gagtttcaat ttacttaact ggcaaatgga ataacaatgt ctacttcaca 50220 gcttactgcg atgatcatat aagacataaa gaacttagcg aagtgcctag actgtagatc 50280 acagtacgtg ttagcttttt gtgttttata catcaagcgt aagtcttatt ttttacatct 50340 gtcatattac cctttcccca gtattcagag tatttgagtg tatacgtacg ggtggtaagt 50400 gttgtttttc attgaaagtg cagatcctaa cttttttttt catgcagtaa tcctcaaaaa 50460 ggtagacgtc taccataatt cagtctattg ctccaattgg aggatgtaca gttgttttag 50520 gagttaagga attgagtttt ttcttttttg cttttcgtct tttttttttt tttttttttt 50580 tttttttaca aattctttta ttcttttctt ctccaaattc aggcaaacag tattaaacac 50640 tttgttttaa aaatagattg tgtacgtgtg tgtgtgtgtt tatgagagag acagagagag 50700 agatgggaga gggtgagaat acacagtaag gacttggaac atattctttg tgtgaaatgt 50760 taaaaaattg ttcacggtgg ctgggtgcgg tggctcacgc ctataattcc agcactttgg 50820 gaggctgagg tgggtggatc acgaggtcag aagttcaaga ccagcctggc taagatggtg 50880 aaacccgtgt ctactaaaaa tacaaaaatt agccgggtgt agtggcaggc acctgtaatc 50940 ccagctactc gggagcctga ggcagagaat tgcttgaacc cgggaggcag aggttgcagt 51000 gagccgagat catgccactg cactccagcc tgggcgacag agcaagactc agtctccaaa 51060 aaaaaaaaaa aaaaaaaaca actattcaag gtttcccaat aaccttcttg ggctttgaag 51120 ctagagagcg ctttggaatt catgctccat tatatgtgtg tcttaatgct atatactgtt 51180 gtaggtcagc aatatttata tacataagtt tatatatatg tatatataga tcttttgtaa 51240 atagagggtg gatactttgt ccccaccttt tcccatccta gcatgcagta taatgatttg 51300 aacacggcaa ggacaccaca aaggcacagg aagacatcct gcaatgtaca tatagtatgt 51360 gccttatgta cagtaagggc cctgaattta aagttaaaac ctagattgga gaattctaac 51420 tttgtgttat cgtgagcaaa gtagtttact taagtctctg attctgattc ttccttgaca 51480 gaaagggaat acaggtgact ttcttataga gttagctgag gattaaatta atagctgtat 51540 gaaaatgctc tataaactgt taaggactat acagatgggt gagtgatggt gtcatttatg 51600 gaaatcagta gatgccatta ctctccatac tgtcgataca tagtctccca tttcttctta 51660 tcagactggc ctacctagtc ttccggtaaa aagaatatcc cgcagataca aattaccatt 51720 actggaacag aggactcact tttagagcag atgtacaaat gaaactccaa aacaagccac 51780 aaatctacca ggaaagagaa ccaatatgtg tggtattata tcgccaagga tacctgagtc 51840 atttcataga aattgagctg tgagtgcctc ccagaatgaa tggtttctga acgtgtttct 51900 gttaggaatg atgcaacctt cagtagagac cagagattta agaattctat actgtgagtc 51960 attttaaaag acaatcaaag agtatgtgtg gaagcataga caataacttt cacctctagc 52020 gtccaggtgt tgaaggaggt cagctaccag ggaaggactc ctacgacttt gggtgccact 52080 gcgtgaggct ttgtcttgga ccagggggta aaacatatct caggcaggac gctgagctct 52140 aggtagggct atcgtttttg tagaagcgtg acttcttgat acaacaaagt aagagctgag 52200 gaaggaacag ggaaaaccag tttgggccca gaggggaaag aaatgatagt gtagtagccc 52260 gcggttttgc aggcagttgg gagtagcaag ccacccttag ggggaggata atgttttctc 52320 taccttaagg gaaaatgata gctgacttgc agagcagtgt gctgagacag acatgctgct 52380 actgcagtgg aagggggttg caacgtattg tcttctgtct ggagagagag agagagagag 52440 cgcgtgtatg tcacgtctgt gtccataaag ctctccgatc tgcccaccaa ccctgtcccc 52500 caccaataac atcttaaaga gaagaggtac aggaatgttt tacagtgaaa agattacagg 52560 gctggaaatt agaagccaca agttctaatt atgtctcatt gctaacttct ggtgtgatat 52620 tttctctggg tctctcattt atcggggagt taaactaggt atgtccagta ggggtgaggg 52680 gtaagagttc tctgcccatc cagggtttct actagaagaa ttttgactct acagataatt 52740 gtgtcttcct gtattgctga ggaatgtcca ggtttgtttt attgaggggc aggggagcac 52800 atagatgtcc agtagtcagg aaggtggttt gcaggccttt aatcagcact gagaagaggg 52860 aaaactaact gcagttcagt tctcagttcc accattcact ggagtgctgc tttcaacttt 52920 tgagctcctg tttctacacc tctaacgtat cagtgtcatc tcaccctggc ctttttctca 52980 tgatggtcgt gactttagga aacatgtaag agtaagccga ccttaacacg agtacctgct 53040 gtatgacagt cactctgaca aatgcctccc agtgtctgct ctgtgaaggt aactgtgaat 53100 gatattactg gtcaggtggg gttgacagag gtggccctgg caggagacac taaatgaaag 53160 gtcattttac cctcctgggg agataaagtt gcaaaattac cgatcaagtc tgtcaaatct 53220 ttttagactg ggtttccaaa tccataccct caggcaacta gaacaaggct ggcgagctcc 53280 acccccgccc cttcccaagg tgggtgccaa catgctgccc ttcagcaggg aggacacagc 53340 tgcctctggg gccagtgccc agggctagcc acaaagctgg ctatggcctc cccaagaaga 53400 cccaggacac attactccct gcagaggttt tgctgctttg tggcacggtc taagtgtcgc 53460 cccactccca ccacctgcca ggcccagtgg gctcctggct ggtcctcacg gtaagtgagt 53520 agcagacagc ccacctgctt gatgtcaaca tttgtgggcg cggcccggga agaatgtgcc 53580 gctcccagcc tccttggctc aggtaattaa tccccgcaac tgacaggtgg caacaggcgg 53640 ccctttggct ggagccatca ggaaaagtgc ttggaggaag gattttttta aaaaaatgat 53700 caagagcaca attcgtacat gtctggcagc tagacggctg tggcaggaag ggaggcaggg 53760 agaagtaaat accttgccaa gacgactgtg gggccaatgt tgggatctgc gtctgcctga 53820 tcattgtgat agatccaaaa ggatatggtg gccttggact tgtttgcaag ctcactttgc 53880 agaattcccc ttcctttgat gtggatacag tcttaaaatg gaatgcctca tttgtgaatc 53940 aaaaaatccg gggccaaagt tggagcccca gaggagaaat aatttgccca agatgatgca 54000 gtaagtcagt gggcaggtag aggactagaa gccaaactca atgcctcttg gctttgtttc 54060 catgattcac tgggcaatat ttactgcccc attatacaca tgtagtttag aaatagaatg 54120 acaaaactgg ggtcctagtc aaaggaagga tgatcagttg cctcttgaaa gatattagtg 54180 ttttcaatct aaccacttaa agctgacttc tcaagagaat gcccccaccc caaccccaga 54240 ccacctgtac ccattcaccc cccctacttt ttatttttgg tagttcggga cactgactat 54300 cagaacacat tgacctgatg tttattagga tggatatatt aaaagccatt gaaatgaaca 54360 cttttccttt ttcttttttt tttttctttg agacagagtc tcgccttgtc tcccaggctg 54420 gagtgcaatg gcatgatctc agctcactgc aacctccacc tcctgggttc aagtggttct 54480 cctttctcag cctcccaagt aggtgggatt acaggcacgc gccaccacgc ccagctaatt 54540 tttggcacga cctcagctca ctgcaacctc cgccttctgg attcaagcga ttctcctttc 54600 tcagcctccc aagtaggtgg gattacagac atgtgacacc acacccagct aatttttgta 54660 tttttagtag agatggggtt tcactatgtt gtccaggctg gtctcaaact cctgacctga 54720 ggtgatctga ctcggcctcc tgaaatgctg ggattacggg ggtgaaccac tgcacccggc 54780 caacactttt taaacattac attttttaaa aaataatatc tttctcgata tgaaatttaa 54840 aatgtttttc aagtgagttt ttttgtagag gacaaatcca aagtatagta tataattagc 54900 ccatataact tcatgtgata atcagtgtct ttgaagcaga ccaaactgaa gctgtgtctc 54960 agcgctaagg gtctttttac attttactga attggatctt tagaattaat ttttcaaacc 55020 ctccttatca aaagttattg ttggaccctc aaatttttat tttcatgtat ctcatttctc 55080 ttccctaaat cttgcctccc accagattag ctgccagaac tttatctggt tctctggcaa 55140 ccctccatct gttttgtatg atttttcatt cccagcagtt ctaattattg atttcatcac 55200 cctcttaccc ttataaaagg acatttttaa tttggcagtc ccaaggaata tagcttataa 55260 aaagaaaaaa aattaagtca ctgaatgttt taggagagca ctaagttaag acagactttg 55320 tacttgatta acggaattgt tctgagagct ttagagcttg actttttttt cttcctgtca 55380 agtattttgg gttatttgag atagtacaga caacacttta cctcttaagt tttttgaact 55440 agaagccata aattagaagt gcacctggca tttcctgttt gtgactagtg gctatctttt 55500 agataacagt gaagtcctca atgtccttga taggttcttg gtaaactgcg accttaaaca 55560 aaatgatgtg caggagatct tcgagtaatt gtttcataca atgttatttt cttataacag 55620 tgatgagaaa aacaaattgt tttgttatat gtgttttgct taaagttaca gttcccaaaa 55680 atctatcaaa aatgttaaat gaggattcat tgtatttgta aatctcatta tttttctctc 55740 ttttttaaag aaactaaatt caaattcatt cagaaagcca ggcataaagt gagactaata 55800 tgttcgttgg tgtatttaag cctttcttag agttttcttt tttttaagac ctcagtataa 55860 gaacatgcca gacgtgaatt gatctggaat tgcagactcg ggagggcttt gatgctactc 55920 tatctagttg ccttccttga agagggattg agaagagagg taggttatag aattaatgat 55980 ttttttttgt tccgtgagag tttatttcat ccatagtctc taagatttag ggctcaagat 56040 agccatgtga tttgagattt gcatgtagta tggcatttct tctgggagag gatgaaagag 56100 ctaaagttct tgttttttgg ttttggtgta gtaggcaggg agggttttga ttctaccttt 56160 aggaaaggga ggtgttgaaa aattacgcag gtgtgtgctg atattacctg gcacctctat 56220 gcattgtgat actgaattac cagtctgcca gccaaaagcg tgtaatatag tatgtctact 56280 gaggcaggtg gtaaaggtag ggtcctagtc actggaattc tttttttttc ccccttctct 56340 ttgcaacata ttattagtaa aggagctgaa tttacttgtt ttccaaaatc ccctggagtt 56400 gttttatttg aacatgatat ttggctttaa gcagctcacc cctcgatatt ccaaacttcc 56460 tcccctccct cccaaagcaa aacaaaattt aggcaaagct tacttatcca ttttgacaag 56520 gatattttat aaaaagaagg agtttagttc atttgttagt tttcaggaac ttcttttcca 56580 tgtcattgtt gaaatattta gttcatgtgg atggccaaaa ctgtcatgtc agtatacaag 56640 gaaatttggt tgaagatcag tacaatatta ggctcatcat tcttgcccat gggctggtgc 56700 ttcctgggaa tgaacaaact attgaatata tgtacagtat gtatacagaa gaacatatat 56760 taagttctac tttatatatt tatacatata tgatcagaaa tggccagtag ggtgtgtgtg 56820 tgtgtgtgtg tgtgtgtgtg tgtgtcatca gaaagattac caacactttg ttttccacat 56880 tctttttttt tttttttttt ttttttgaga cagtctcact ctattgccca ggctgtagtg 56940 caatggtgtg atcttgactc actgcaacct ctgcctcctg ggttcaagca attctcctgc 57000 ctcagacttc tgagtagcag agattacagg tgtgcatcac cacacctaat ttttatattt 57060 ttagtagaga tggggtttca ccatgttgtc caggctggtc tcgaactgct gaccttgtga 57120 tccacccacc tcggcctccc aaaatgctgg gattacaggc atgagccacc acgcttggcc 57180 ttccacattc tttattaaag agtcactttg ccagtgcaaa tctggtaact gcgttctcta 57240 agagatttgc accaaattat aaaataatca aatgaggccg gacacagtgt ctcacgccta 57300 taatcccagc acttctggag attgaggcgg gcggatcacc tgaggtcagg agtttgagac 57360 cagcctggtc aacatggtga aaccccgtct ttacccaaaa tacaaaaatt agctaggtgt 57420 ggtggcgggc gcctgtaatc ccagctactc aggaggctga ggcaggagag tcgctagaac 57480 cttggaggca gaggttgcag tgagctgaga ttgcaccatt gcactccagc ctgggtgaca 57540 gagcgaagct cagtcttaga ataacaaaaa taatcatcat catcatcatc attatcatca 57600 aatggaagta acactataca ttatctattt tcccctctat gaatgattag ctcaagattt 57660 ggggggatca tgtaagttgc cagttatttc tcagtgagtg tcagatattt atgacttctt 57720 tgaagaggcc aatcgttttt gaaaattatt tcagatgtgc tttatttccc cccacccatc 57780 acagtatttt atttctgatt tcacttagat ttgcataatg caaagagcca cagttgcact 57840 gggggtcctt tctaaatagg caacgaggtt agtgcaaccc actgctgact tattgaaccc 57900 aggacctgat ggagtagagt tgattcttaa agcaatgagt gggcattttg tgttgttttt 57960 atgttcaagc tcccattgtg agaatatggt tacactttag ggaagaaaac ctcaactctt 58020 agacaaactt ctttgcttaa ctaaaaataa gtatatatac tcctgtaaga atttggtgat 58080 catattttta tttttgttag taagatggcc tctgagcttt acacttgatt gtctaatcat 58140 atattttcta atcatgtgtt tattcactca aattcactct ggcacgaata caccagttcc 58200 actttggcct catactataa ctgttaaaac tgtgtgggac gtggggaaga acactggtct 58260 gtatgtcaag atggtcccag ttactgagaa cttttgagca aatctcttct cctttctggg 58320 gcttagattc ctcatcggcg aataaagtgg ctgaaccaaa tgatctttaa ctttgaattt 58380 tcctgatcta acttttcctt ttccttttcc tccctctgcc tcctcctcct cctcctcctt 58440 ctctctctct ctctctctct ctctctctct gttgcctagg ctggagtgca ctggtctgag 58500 gatggctcac tgtaacctca acctgctgca ctcaagtgat cctctgcacc tcagcctcct 58560 acagatgccc ccatacctgg cttttttttt tttaattttg tataggcaga gtcttcttgt 58620 attgcccaga ctggtctcaa attcttgggt tcaagcaata ctcctgccta gacctcccaa 58680 aatgctggga tgacaggcat gagccactga acttggcccc tgatctaatg ttctaaaaaa 58740 atcttagcaa atgtgtgtta aactaaaaat gctttgaaat gggatgactc agtaatagaa 58800 acatagaacc aagcccttgc tttaagatgt caagttggat ttctacagaa attctgtaat 58860 tagaatataa tattgtagta aaagcattat cttcatagaa ctaaggaaat ctgagttcac 58920 ttcttcatta cccaaattta gttgtgcaac ctttagaaat cattttatca gggatgcact 58980 cctgaccctc tgtgatatca tgaaatacgt atttggactt tgtccaagtt tcttggcata 59040 taactcctaa aatccttgga atttccaaaa tgctgccttt tttgtatgct aatgctggct 59100 catgggttca gaatgggggt ctggtcactg gaaaggcaaa ggcacaatta gagagtcagc 59160 cccacccccc agcctccagg aaggagagag aggctgaagg ttaagttgat caccacttgc 59220 caatggttta atcaatcatg gctagataat gaaaccttca taaaaaccca aaaggacagg 59280 tttcagcaag gttcaagata gtaaaacatg tggagagttt tagaggttga agcccaggga 59340 gggcatggaa actctgcacc tctcccccca taccactccc tagatgtctc ttcatcttca 59400 tcctctgcaa catcctttat aataaaccag taaatgtgtt tccttgaatt ctgtaagctg 59460 ctccagcaaa ttaatcaaac ccaaattggg gtcatggaaa acccaatttg aagctggttg 59520 gtcagaagtt ccagaggtct ggatttgctc ctggttgtgt gtggagtctt gggaactgag 59580 tcttcaacct gtgcgatatg acagatctcc gggtagacag tgtcacagtt gaattggagg 59640 acacccagct tggtgtctgc tgcttggtga gtggtgaaaa actcccacac atttggccac 59700 agaagtcatc ttctgtgttg atgattgttg ctgtggtaat gtgagaggag aggaaaaaac 59760 acagtttgag catttcccaa aacatcctcc aagctaaata gacccccatg ttttaccttc 59820 tctccttttg cttttttttc aagacatgtg tcacaatttt agaaattatt ttttttaatg 59880 tcagtacttc ctttggatca actcccttag tgtaaggttt accgttggtt ccctaatagc 59940 caggacaagg actggcatga agcgcgtgct caataaatat ttgctgaatt aataagcttc 60000 acctctttaa gtctcagttt tatatcagaa aattaggaga agaaggtttg gacaagaggt 60060 gctataatgt tccttctgag ttctaacatc ttctgtattc tctgtcttct aaaatcatag 60120 gtctgtaaca agtttacagg ttggtgctac tcataataat ttatgtatta aacattttaa 60180 gtgagaaata tttcaaggtc aggtgtggtg gctcatgccc tataatccga gtactttgac 60240 aggctgaggt gggtggatca cacttgaggt caggagtttg agaccagcct gaccaacatg 60300 gcagaacgct gtctctacta aaaatacaaa aattagccag aagtggtggc actcgcctgt 60360 agtcccagct gtttgggagg ctgaggcagg tgaattgctt gaacccagga ggtgggtgtt 60420 gcagggagcc aagatcatac cacttccctc cagcctgggc aacagagtga gactccatcc 60480 ccccgtaccc cttcccccac cgccaccacc aaaaaaagaa ttatttctaa cgtaaaaaaa 60540 gtaagtaaat taagacatct gagtataaga caaaatgtta acatttttcc atattgcttc 60600 aaatcttttc cttaaataaa atataaagca aaaagtactc ctccattcta tctcatttcc 60660 cttctttcag ccattaaaat gaataaaata tacctgtata taagaacatg gataaatctg 60720 ggaagcatgg gaattgaaaa tagattacta aggctaaatg taggatgatg taaattaaat 60780 tttaaggaca cggggaggga tagcgttagg agatatacct aatgctaaat gacgagttaa 60840 tgggtgcagc acaccaacat ggcacatgta tacatatgta acaaacctgc acgttgtgca 60900 catgtaccct aaaacttaaa gtataataat aataaaaata aaaaaaattt taaggacacg 60960 caaaattata ttacatatat ttatggatgt gtattaaaaa tgtatgggag taaataaaat 61020 tcttttttta taaatgaatc tagtaatttg aaatggttaa gaacttaatg attattaata 61080 gataaatatg aattgtgtga tttattttaa atggttaaca ttcaaacttt agcagacttt 61140 tactatgtca acaaacactt tctcaccagg ttgagataca gttttcacag tgctgtctta 61200 aaattactta agctatgtta aacactttat gtggagaatc ttagaaatat gaggcttcag 61260 tcataattgt tatacatgac ttttattttg atctttgcag ttgagtaaga attttttaat 61320 ctattttttc tttcacctta agagatgtga actataattt tttccatttt atatgtgtaa 61380 tggtgaagtg gccaaaatgt gggttagatg ttattgtatt tcaaagcgag cttgggaagg 61440 ggcgcaaagc agtctgcctt taaatgtgtt atttccagcc aggcgcggtg gctcacactc 61500 gtaatcccag cactttggga ggccgaggca ggtagatcgc ttgagcccaa agagtgagag 61560 accagcctgg gcaacatggg ggaaaccccg tctctgctga agaaaaagaa aaatagaaaa 61620 aaaaattaac cgggcgtagt ggtgggcgcc tgtaatccca gctactctgg aggctgaggc 61680 aggagaatca cttgaacctg ggaggcagag gttgccgtga gacaggatcg cgccactgca 61740 ctccagcctg ggtgacagag cgagactctg cctcaaaaat aaataaataa aataaaatgt 61800 gttagttccc ctttggagca gaaagaagtg gacactttta taaggtaagg agggaagtga 61860 acaagggcag gcggtccccc tgctagcttg gtgcctcatc tacctgatag ttgagttggc 61920 accaacccgg gcagaaataa gttgtgaaaa tggccaagca ggcagactta agatatgccc 61980 ttctgatggg tgaaagtccc aaggccaccc cgtgaaggtg aaagttccat ggcaggtgtt 62040 ctctggtttg caaatggact atcagctctc caggagagat ttgtcttgga gcacacagtt 62100 agaacttacc ctgcagggag tatctggtga ggaggacgtg aagggttata tttgcatttc 62160 tgaagggcta agtaggaaac agggaacggg aggaaagggg acaggataag agaaaataat 62220 aaaaataata gtaactcatt cctcttttct tagaagaaat gggagtactc agttaagact 62280 acatgaaggc agagggaggg aataaaaaga ggaggcagaa tttaaatagg attttttaac 62340 tcctagtcca ataaataaat gatgcccaca gttgttggtg ttggacaaga gtctgttttc 62400 tgttgctttt agatctgaga actgagccct ctccttcaca acaaaattgg cctattaatt 62460 ccagtgttac ttcatgtaat ttttttattt gtccagaact aaaactatcc tttctctatt 62520 gtcgacaatt ccattggcta agccaggttt caattgtctg ctgaatatca ggagctctgt 62580 gttaaaatta actcattcat tctgctttga ttttagaaaa cagataaaca actgatagta 62640 tttttgcaag catcttttgt tctaaagcat aatatgtatt ggtctgtttt ggtacttcca 62700 tgtatgtatt tcatgttaaa accaagaagg ctgaatttag taaatccaaa gagtttcccc 62760 catcattttc ccttttcatt catttctact gccctaggtt gggccttcct catttcttgt 62820 ctgaatagct cctgatgggt ttccccaatt ttactttgct tgttcccacc acctttgtat 62880 ttctgaatac aaagaactga ttaggtcttt cccctacctt ataatcctca gtgacacctc 62940 tttgcctgct catagtagtt aacggtatct tgtgacatcc aaggctcctc agaatctggt 63000 aagtgccttt ctagctcagc ctcattgact tctgctcggc tactcctcct ccttccccca 63060 tcccatctat atttcatcca cagttaacat ccccttgctt ttactgatga tattctgtct 63120 tcatggaaag cctactgttg tctcctggct ttttcttcct ttctttcttg ggtgcacaat 63180 ccaattggtg aataataact tcttttttaa ggcctagttt aaatatcact acctctatga 63240 aaattgtctt ttctatttta attttctctt tcttatccca gccagttcat cagctaatct 63300 ggtgacttct catcacctct actgctggtc taagccactc tcatcttaca cttggattat 63360 tggcaggagc cccctgactg gtcttcctgc ttccgtcttt gttccacaaa gtctgtcctt 63420 cacataacag ctacagtagt cttatagaaa taaaaatcag accacatcag ttgctcaagc 63480 ccctctagtg gcttcctatc tcacacgaaa aaagctcaag acccgtcctg ctctacaagg 63540 ccttgcgtga tctgggctcc ctattatctc tgatcttgga tcttaactcc taccactgca 63600 ggctttgctt acttttctgc aggtgcactg gcctccatgg caagcatacc cagccaggac 63660 tttagcactt gctgtctcta gtacttggaa cactatctct ccaggtatat atatggccca 63720 gctcattatt tcctccagac ttttttcttt aatatcatct tattgaagaa ttctttccta 63780 acaatcttgg aaaaaataat atcctcttca cactcactcc cctgactctt ggctttttat 63840 actctatccc ctttgaattt accctgattt actttttctt atagcactta tcactatctg 63900 acatagtagt tatttgttta ttctagaatt ctagcatttt tagggcatag actttgtctt 63960 tgtttaatgc tgaatttcca aaactaaaac agagccttgg taatagtata tgctcaataa 64020 aaatcaaatg tattacctag tagttaattg ttctatctct gtaatcccat aacacttgca 64080 gatggttcct ttatacccag tgtattttgg ttgtttttgc tgtactctgc ctctagactg 64140 tgagcaactt gaggataaag atcgattttt ttctttcaat ttattttata tttcaagtac 64200 catcctaggc agcatggata cataaaattc tgcattccag gattttaaag tcttacttct 64260 atctgttccc agtacagaat aaggacctag cattgtgcaa tacatgctca gtaagagttg 64320 gctagattaa gtattgaatg ttgtacaaat gagaagagct agctctcatt tgtggtttat 64380 gatggcaact gactagcagc ttttagtgta gtctctccta tgttgttgtt tttatgtttg 64440 tttgtttgag atggactttt gcttttgttg tccaggccgg agtgcaatgg cgcaatctca 64500 gctcacggcg acccccgcct cctgagttca agcaattctc ctgcttcatc ctcccgagta 64560 gctgggatta cagacatgtg ccaccacgcc cagctaattt ttttgtattt ttagtagaga 64620 catggtttct ccatgttggt caggctggtc tcaaactcct aacctcaggt ggtccacccg 64680 tcttggcctc ccaaagtgct gggatcacag atgtgagcca ctgcgcccgg cctctcctaa 64740 gtttgtatta aaatattaat attacaaatt ccagaaaaaa ttaaactaaa ttggacactc 64800 aagccattgg cagaatttta taataatttt atgccctaaa agcctgatag gatagaactg 64860 aaaaatgtca aaatgaaatg aaagctgcaa acactagctg tggctatatc ttgctatgtt 64920 catggaaaag taaaaaagcg agaaagggct tatattaaaa acaaacaaaa tcctatctat 64980 aggggaacat cgttttaaat actcaagaaa atcaacttag gaactggaag aaatatttag 65040 aagattactt tggtgcaaat taataagaca gtaacactgt aaagttggga agacatggca 65100 aacctaaaat tgcaggctga gatgtaaaga ggactagtaa aaagggatga agattaaata 65160 aggaaggaca tttgaaatgc agcagaagaa gtgaaagtat tatttgtagt agaatagagc 65220 agaattaagt gtagaaaacc atacacatac tgaagacaaa tttaagaagc tttcccaaaa 65280 tgcaaacaat aggaaaaact gcataaaata tatggcggat agaaagtgga gatcctaaag 65340 taagacttaa cgtgtttctg gaaactgata cgagcagaag aaacaaaaat acaattgaag 65400 aacaaaatgt attgaggtca agcatgaaag ttaaaaggac ccaccaattt ccaagtaact 65460 tccattttaa aaatcacatt tagagacagt gccactttat tttttaaaaa agataaacaa 65520 aattctacaa gaaactatgg aaaaataagc agcttactta atttaaagaa ataaaattca 65580 gattgacctt ggacttttct acactgaaat gtacattgac tcaattactc tgttttaaga 65640 gatctatcta aagccaattt atatactaaa ctgtgctata tggtgttatt tttaactgga 65700 gtaaaattta tacagaagta tactaaatta tactattcta ctaaaaagtt acaattaaat 65760 aaataatggt atatcccttt ttaatactgt gacagccacc acttaaaatc atgttttaaa 65820 attagaacat gctcatgata tattaaatta taaaaagaat accgtctttg tattatatgc 65880 ccctagtttg tgtgtatata tgtgtgtgtg tgtgtatgta tgtatgtgtg tgtgtatgca 65940 cagaaaacgg tcaacaatgt taataatggt atgtatctct tgagtaagca agaaatcatt 66000 tttttccaga attctgtgtg cacatgtttt gacaatgatg aaatattaat aaaaggcaga 66060 ttgtagaaaa agagaagttg gggagacgtt gacaaaagtt ttaaattttc tgtaacggct 66120 tctcatagtg acaacactac agggcaaggt actttatacc ttcacataga aggtttgaaa 66180 tatttgctat ccacccaaag agctgctgga aatttaatac aatgggctgg cataatcaaa 66240 aaagttctta gctatagaag atattttttc aggtataaaa tcaactgagt acttaattta 66300 atgcctataa gtaggagaaa cctacataga gatataaggt aaccctggga atagcaatta 66360 aaaaatctgt ttagaatggt aaagaaatgt gtaaaggaga aaataagttt gagctagaaa 66420 tggaacccgt gaaacaagca gaagacctag agaattaatt ttcttaggaa tgtgagtaag 66480 tgttgtattt gatatactgg ttatgaggac tgataaaaga tttaaaagaa atgcttcaca 66540 tatgactcag tattaagaat tagatatatc aaaactttgt ggacatagct aagaagtacc 66600 tagaagaaac ttggtagaat taaatgttta tattagaaaa aaacgtgaaa gtctaaaatg 66660 aatgatatat gattctagtt caaaaaaata gcaaactcaa ccctggtttg attattgcag 66720 tcacataaaa ataaaaattt aaaggtatgc agatttgaaa ggaagaagta aaactgtccc 66780 tgttcatagt tgacatgatc atctatgtag atcgtaagga aggcatctac aaaaagctac 66840 aagaactagt aagtttacca aggtcatagg ctacatggtc attatacatg aattaattag 66900 gtataaatac atgacatagt ataaaacgca ttagaaacaa aaagaaattt tcatttttaa 66960 aagtactgtt tataacaatt attttaaaat aaaatactga aggataaatc taacaaaata 67020 ggtacagtat ttatacactg aaaactataa aacatttctg agtaaaatta aagatactct 67080 gtttaaatgg agagatatca tatgctcatg gtttaaaaga caccacattg ctaaggtatc 67140 agttctcccc taaaagacct tacatattta acacaatctc atgcaaaaat cttaccaggc 67200 atttttatgg aaattgtaaa ctgcatgtaa attttgtatg gaaaaatcaa aggatataaa 67260 atagccagaa caatttttaa aaagaacaaa attgcaagaa tcagactacc tgatttcaag 67320 acttactata aagtagatta acccaaacaa tttgaaattg atatatggat agacaaatag 67380 atcaatagga aagagggaag tattcagata cagacatgaa cacatatgac caattgattt 67440 tcaataaaga gtccaaggca gctcaacaag ggaaaatatg caggtaatct tttcaacaaa 67500 tggtgttaga acaattggat atctgttaaa aagagaagaa ttataaaccc ttaactcaca 67560 ccatatacaa caattgactg aaaatatagt tctaaatgga agagctaaga caataaatct 67620 acttgaagaa aacatagaaa atcctcctaa tgtcaggcca agatttctta ggatataaaa 67680 agcaagagct ttcaagggaa aatattgata attaagtatt ttgggaaagc aggaaaaaag 67740 ccaagctaca ggctgggaga aagtatattt ttaaatgtat atctgataaa agacttgtag 67800 ccaaaataca taagggactc ctaaaactca cattaaaaac aaaagcaacc taactgacaa 67860 attaccccaa atcgccaaaa taacccaatt aaaaaatggc caaaagaccg gaatggatat 67920 ttgtcaaaat aggataagca tatgaaaaat gcccaatatc actaatcagg gaaatgcaaa 67980 tcaaactaca atgaaatact acttcattta gaatggctat taacaacaag ataactgtta 68040 gcgaggatgt ggagagaaga gaacctttac atactttcag tgggaatgta aattagtaca 68100 gccattatgg aaaatagtat agaagttcct tgaaaaatta aaaatataac taccatgtga 68160 tccagcaatc tcactactag gcatttatcc aaagggaata aaatcagtat gtcagaggga 68220 tatcttcact cctgtttatt gcagcactat ttgcaatagc caagatatgc aatcaaccta 68280 agtgtccatc aaaggataaa tggataagaa aatgttgtgt ataggccggg cgcggtggct 68340 cacgcctgta atcccagcac tttgggaggc cgaggcgggc ggatcacgag gtcaggagat 68400 cgagaccatc ctggctaaca cggtgaaacc ccgtctctac taaaaataca aaaaattagc 68460 cgggcgaggt ggcgggcgcc tgtagtccca gctactcggg aggctgaggc aggagaatgg 68520 cgtgaacccc agggggcgga gcctgcagtg agccgagatt gcgccactgc actccagcct 68580 gggcgacagc gagactccgt ctcaaaaaaa aaaaaaaaaa aaaaaaaaag aaaatgttgt 68640 gtatatgcac agtagaatac tattcagtca gaaaaacata atgaaatcct gaggttgggc 68700 atagtggctc atgcctgtaa tcccagtact ttgggaggct gagacaggag gatcacttaa 68760 gcctaagagt ttgagacaag cttgggcaaa atagtgagac cccatctcta caaaaaacat 68820 acaccaaaat tagctgggca tagtagtgcg cacctgtagc cctagctact caggaggctg 68880 aaatgggaga attgcttgag tctgggaggt cgaggatgca gtgagccgtg atggtgccac 68940 tgtactgcag cctgagtgac agagcaagaa cctgtctcaa aaaataaaaa aagaaatcct 69000 gatcctgtca tttgcaacaa catggataaa tctgaggaca ttatattaag tgaaataagc 69060 caggcacaga aagatgtaac cacaagatct cactcaaatg gaatctaaaa atgttaatct 69120 catagaagtt gagagtagaa taggggttac cagaggctga gaaggggaca cggggtgagg 69180 ggaaatgggg aaaagatggg tcaatgggta caatattaca gttagacaga aggaataagt 69240 tctgttctat tgcacagtag gatgactata gttaacagta atgtattgca tatttcaaaa 69300 tagctagaag ggaggatttt gaatgttctt actacaaaga aatgataaat gtttaaggcg 69360 atggatatac tacatatcct aatttgatca ttatacaata tagacatgta tcaaaacatc 69420 acattttacc tataaatatg tacaattctt ttgtatcaat cataaaataa aacctaaaaa 69480 gtgaaatttc tgtgttacaa agggggagaa cacagtctgt attacaattt ttttaactca 69540 aaaggtacaa aatatttgaa cagatgcttc aaaaaatatc aaatagttgt atagaattac 69600 ataagtttgt ttttattttt attatatata aatatgaatg aaataagtac atgaaaagat 69660 gttaaacatt attaatcatc agaggaatgt taatttaaac cacaatgaga tctgcataca 69720 taccagaatg acatcaatta aaataacagc tgacaatacc aaatgctgac aaggatatga 69780 agtcctcata tattgcaagt gacaatgtaa aatggcacaa ccactttgta aaactatttg 69840 ggagtttgtt agtaagcata cacttaccca gcaatcatat tcctaggtat tcaagaaaaa 69900 tggaaatgta catcctcaca aaaatttgta catgaacgtt cataatagtt ttatacacaa 69960 tagaaaaaaa tggaaataat tggtgagttg acaaataatg aagtgctatt caaaaataca 70020 atggaatgct gatacgtgca aaaaccacag ataaatctca aaagccttat cacataagat 70080 tatatactat atttttccat ttacataaaa ttctggaaag gtaaaactag tggaggaaac 70140 aggtacatga ttgttgaggc caggagctag ggaggggatg aactgcaaag aagcaaaaga 70200 taattggaac aggaatggaa atattctata tcttgattgt agtagtagtt gcacaacggt 70260 gtacatttgt caagccatca gcttttgcac ttaaaaactg gtatactttg cggaaaagta 70320 taccacataa aacaaaaccc ccatacaaaa aagaataaat taggccttag aatgaaaaga 70380 atctcaagtc aatgttgagg agcaatttag acgtgaattt tttaaattcc acagagaaag 70440 aaagatagta aaataagcca tgtgtgttca aatttacaat ttctgctgac ttgaatcatc 70500 agggtatttt aaaatcttgc tgtaaatcag attcccatgt tccaatcttg cagaagccgg 70560 gaaaattgga gatgatggtg ctattttgta agggatacgg aagtgggcaa gtctaaggac 70620 ttgtttatac acatagacca gggagactga acttagtact gggtaaaaaa aataaaggtc 70680 atcatggaac agatttgcaa acaatgaagt aaacagaata gcagagattt ggctttgtaa 70740 aaagaaaaaa aagcgattgt gccagaccac ttcagcgcct ctagttgctg aattgcagga 70800 ctggtagttg aaccaaaagc aataaacata atgcatcttg gctgtggtca gatattttga 70860 tttagtcaaa tatgaagccc tcaccactaa aattggaaaa tatggtttgc agtacagata 70920 cagtactagc tgaaaagtga tatctgaatt gtcctggcat gacgtggaga gcagaggaaa 70980 aagagaagtg taccacactg ggaatatcac ttttgttgtt gtagttgttg ttgcttgctt 71040 gttgctttta atttttttag gtttcagatt cagtaggtac atgttcagta ttgttacatg 71100 aatatattgt ataatggtga ggtttgggtt tctagtgtac ctgtcaccca aacagtgaac 71160 attgtaccca ataggtattt tttaacccgc atcccctcct accttcctca tttttggagt 71220 cctcagtgtc cattatttcc atctttatgt ccatgtgtat ccttttgggg tttttgtggt 71280 tttttttcgt atgtttagta gagactggat ttctccatgt tggccaggca tgtcttgagc 71340 tcctgcctgc ctcggcctcc caaagtgctg ggattacagg catgagccac tgtgcccgac 71400 cacatgtgtc ttcactactt atctcccaca tataagtgag gacacatgat acttgatttt 71460 ctttttctga gttgtttcac ttaggataat ggccttcagc tcaatccatg ttgctgcaaa 71520 ggacatgatt tcagggaata gcattttgaa ttttgggtga tgatcctatg gtgtgtttga 71580 agcattaaaa cgtttgtatg ggtagaacat ggggtgagaa atgtgtgtgg gtgggggtgg 71640 aggggtaggg ggaattagag atagataagg ccataataca gagggcctca taaagtcctc 71700 aataaaccat gttaaagagc aagactgtat ccttgaattc ccagaagcag ctggtgtaat 71760 cgtccaggct gtcttccacc tagcccaaag ttttttcaac tctatcactt gctgcctctc 71820 cctaccatta aatgagtaag caatatactg agaaattaat aaaactatgt taaatagacc 71880 acttttgagc tccattttaa tgcttggaga agagtcggta agcattgtaa ttgattcaga 71940 aaagaaccac aatgttggaa actagaaaaa ggtaaacatt tgcatggctg agttaagaga 72000 acagagacat aagaaactgt tattacagga ctaggataga ctcatatacc agttactaag 72060 caggttcttg ggcaagtcct ttctgtacat ttattttctt atttataaaa tagggatgat 72120 aattcaagtc aattatctgt tatctacaat tctgaagttc caagagctct gaaaatcaga 72180 agttggttca gttttatttt gatttcttaa gtttgtggca cactcatttg atggtgaaac 72240 ccaggtttcg tagtcattta tcagttagtg tgaatattta tgaattctgc agaaataatg 72300 tttgatctta tggtgctacc ctaaattctg ctggatacat tcatatgtta tgcaaactac 72360 tatttttcta aaatctaaac aattctggat tctgaaaatt ctggcccctg tggtttcaga 72420 taagagacag tatgcttgta ataccttcct cttagggttg tatcaggata aaatttctta 72480 aggcagaact cagtaaacga tgaagctatt attatttatc attaattaag cttaaaaatt 72540 agattcccac ccccatcccc gagaatgaac aagaattagc acttgacgat ccttaatttt 72600 attcttaatg cttttatact gtactctctc gagcttgatt tatagtatat cagttattaa 72660 aatggaatgt tttccttaag aaacttctac gctgaacact taaccttcat ttctgcaatc 72720 tttacatact tggaaggata ccttatttgc ctttaggtat tagttgacag acttattttt 72780 cagtcatctt tcctaagggt catcttacga aattcatggt tagattatgc gttatatacc 72840 tcctaacgaa aacacgaatg gatatgctta ttttcttcaa gttctcaata aaaggaagtt 72900 cttaacatgt cataaaacaa gttctgtgta agtctttagt taaaagcact agagcaaaaa 72960 tacccatcta gatttcattc agtgtttccc aagtagaatt ttatttttgt ggttgaagtt 73020 tggcatgttt cctatttctt caagctatat aaaacccttt tgctgcgtct aatccatggc 73080 ctgcggacat ggaggactga ttttgcaata cttttctagc attgggaaac ttctaactaa 73140 aaattttgtg tgctggaata cttggaagaa aaggaaaggt catttaaaca aatactatat 73200 tttaaaatga agaaataaag caacatttta aatgtgtgat ttttgttaag atacttgcca 73260 ttagtgagag ttagggtggg acatatcagt aacgaatccg attgccacta tggctctgcc 73320 cccccaccat ctttcctctg ggaggatgtt ggggccaact tacgattgca acctgtgtgt 73380 gtgtttatcc tttgtttgga tacatgttac taggtgcccc actcttggcc agcaattcca 73440 gtgcctgggt ggtttgcctg agcaaagtgc ctgagtggct aggaatgtag agatagggct 73500 ttgacccaga gcacagggat gataaggttt actatagtgt aaggattaga atgaaggttc 73560 tcttctgctt cagaagtggg aagaggaagc aacacaggat gggatctcta tctggttcta 73620 ggtctcaggc tttctccagc ccgttttgcc aacttacaag caactaacca ccactaaact 73680 tcctctccct ggagaaggaa aaatttcact cacttgtgag tgagaagatc tgcatccaga 73740 tcctttctgt gccatgatta gctgtgctac atcaggcccg gtgttttcag gagtttagga 73800 ccaaacagcc cctttcagct cttgcattct cctagtcttt gacatcagaa ggaaagtgca 73860 ggcgttcaag ggagttcttg ttttacagtt tcaagcgatc tgacgtcagg cgaaatctct 73920 tcactctcta acagatattc catcttaaaa aaaatcccat gaaccctaat tcctgtgagt 73980 gtctctaaag tatattaaag actggattaa ttgtaatcta ggcagaaatc tgtctttgtg 74040 gttgttgttt aatatcactc agtacatgcc aatactcttc tttcacttag cttctggtaa 74100 tctatgaagc tactcgtggt ttcattcatt taaacccctc tgagcctcag cttcttcatg 74160 ctaaaggaaa ataacaggaa ataatggcat aaatgtgttt tgataaacat aaaacctttt 74220 gtaaacatgg ggttttattt atgatagcac aaaatattaa tataacttcc tctaataaca 74280 ttgacatacg tcacatctat agtagccagt agtaaacagg cagcatgcag ctctaaaaag 74340 tggacagatt ttcattgttc tgatttggaa tgtaacaata tctcctgttg gttctctcct 74400 tcctttctcc actggcccca actctaagca gtattccact gaactgaaga aactctactg 74460 ccaaattgca aagacatgcc ccatccagat caaggtgatg accccacctc ctcagggagc 74520 tgttatccgc gccatgcctg tctacaaaaa agctgagcac gtcacggagg tggtgaagcg 74580 gtgccccaac catgagctga gccgtgaatt caacgagggt aagcagaatt tgaatctcta 74640 actgttcaac ctccttgaag gtcaagattc tgtgggcatt tttgtttgag acccacctac 74700 ctgattcaga cttctgcact ccgatggcag atcagtctgc cttttttttt tttttttttt 74760 tttttggctg acagtatcta agaataatga taaataaatt catggctttc acagtggttg 74820 aactatttaa tattagtaat tactagatga cctgaactac tggttatctt tactccttcc 74880 tgcttccttc tttttatttt tcttgccttt aaaataaaat aagaggctgg gtacggtggc 74940 tcatgcccgt aatcccagca ctttgcgagg ccgaggtggg cagatcatga ggtcaggaga 75000 tcgagaccat cctggctaac acagtgaaac tccatctcta ctaaaaatac aaaaaaatta 75060 gctgggcatg gtggcgggca cctgtagtcc cagctactcg ggaggctgag gcaggagaat 75120 ggtgtgaacc caggaggcca agcttgcagt gaaccaagat ggcaccactg cactccagtc 75180 tgggcgacag agcgagactc catctcaaaa ataaaaaata aatgaaaaaa aaataagagg 75240 gtgccaggag actacatggt agctattcta cttggcccag gctacagttt cttcagattt 75300 agtgttttcc cagaaagatt ctcaagtcta gaccagttga gacctggaag ggtaagagaa 75360 aggagcacca aatgaaagaa ataatgaaaa aaccagaaga agaaaaagga aaaaaagatg 75420 agaaggcaag taatgggtaa ggggaataaa tagaaggcct agagcatact gtggccaatc 75480 aaataaagga ctgggagtgg agggatgagg tatcatgaag gccaccttta gacgctatat 75540 ccatgaataa gtcatgcctc atattctaca tctcagatcc tacaacaatt tagcagaaaa 75600 ggtcagcaat gccaagagtt cccttagatc tgatattata gttccatgaa gggagactaa 75660 acagagagtg ctgaaaagtg gaaggtaaga gcaggataaa gcataagcaa tcctcaaaga 75720 gtattgaggg tgccaaaggt gttgggggtt aggatacttt atagaaaaaa tattaaaata 75780 taaggattga taaatataga gagtataatt gtagagaaaa tcaatggaag aagaaagaga 75840 atggatcgga atttaaaaga agaaaataaa gtcaaaattc tctttaaaaa actatttttt 75900 acacattaat ttcaagtcct tgcccacatg gccacattat ccgtacattt atctcttgct 75960 tttcacttaa caatctgcca taaagaatat tgcaatatag atagacttca ttatcagcct 76020 ccctaacttg gtatttcacc aagataacat actatttgta agcgttttcc cattttttaa 76080 acataaaaat tgtttttagt tttaaccata atagatgatg cagcagagaa cattttgata 76140 tgcttcactt tttactttta ttgaatggtt tttgtagact gggactatag gacctaagag 76200 ctgttaaaaa cagctttacg ggtcccagtt cttggagcat cttctttttt ttggagctct 76260 gctaaatatc acaattttat gaaactttac tcagtctctt ttttaaaatt gcatcccttt 76320 tcttacaccc aacttgggac tccttcaaca cacaaacacc agaacgtttc ttatctttat 76380 aatcaacaca atgtttaaaa gttgaggagg aggaaagaag aagaagtgga agtcatatcc 76440 ttgctatctt ctgcttctca gtgtatttgc tggtcagact tttgggcagc attttctcag 76500 ttaaactgat ttttttttaa attaatttgc ttatttccct ttcattttcc aggaagctgg 76560 caaaatttcc tccacgatga ggtcagagat gtagttatag agttccataa agcttgaatc 76620 attaatctta aactccaaat tataggactg ttcccttaac tgtagatgtg cattccagcc 76680 ctttctgttg ctataaaggt tatgacacct tcatgtattt gatatctggc tatgggatct 76740 gttcgtttct tcaaggatgc acattttctt tattatacag actatttctt ttgccaccaa 76800 catcctgttc atgcaatttc attttatttt ctttattttt aaggtaaaga actaactctt 76860 ttattgtttt ctgctctgca ggacagattg cccctcctag tcatttgatt cgagtagagg 76920 ggaacagcca tgcccagtat gtagaagatc ccatcacagg aagacagagt gtgctggtac 76980 cttatgagcc accccaggta aaaagcaaaa aaccaaacca aaaaacaaca cctctatgga 77040 ctgagtagac ttgagagaac atctgtttca gcaacaggga tgtttctagc atctatcact 77100 gtcttagttc ttgtcatcaa atatataata tttttgtatt tttttctacc tgttctccac 77160 atgctttccc ttcagaatac ctaaatatgc actgaatcaa cttggtaaca tggctctgtg 77220 tccatattcc catcttaagg gcagataaca attgaactgg caattgggtg tatacatgag 77280 attgttttat ccaactggca gttggacggg tagtggataa gcaatagtag tggatgcaag 77340 tgttaccata agtgggaaag cctaagaggg atctcttagc tgaagtttga atgaacagat 77400 gatagatttg taaatctgtt gcatgaagca gagtagtgtg gttgaaagta cactggtgta 77460 acaggaccca agttctttgg tttgctggct tgctgtgtgg accttcggca actctctctc 77520 tctaggcttc agttgcctta cccgtacgta tgtactttgg actagattat gtttaattct 77580 gagaacattt tgagctctaa gatgttatta atggaagtat atattcaaat ctatattgta 77640 ctgttttatc cacacaggga aaatattctt ggagcattgc tactgttttt ggcaattatc 77700 cccagttttc ccttttcagt gatattcatg aaggtggtat agcctatttg aattacatga 77760 tgtggatcag cttacaaacg aacaggatca aagatcacaa aatgttaaag cctgtctcac 77820 ctaaggtagt gttcagtgtt gcaaacatta gctttaagct tccccgcagg caagatgaag 77880 aaaaatctac aacagggttc agagtttgcc cttttaggag gaagcgtatc acttcatcag 77940 aagtggaatt ccttaaatag agggaagaac tgagaaggaa caacgtcagt ttaaaccctt 78000 gttaacacag attatttacc ccttgttttc aggttggcac tgaattcacg acagtcttgt 78060 acaatttcat gtgtaacagc agttgtgttg gagggatgaa ccgccgtcca attttaatca 78120 ttgttactct ggaaaccaga gagtaagtgg cgtatgtaaa attgtcattc tacacaaaaa 78180 atcacgagca gagggcaaag tgaaatcgtg gctgctttat cattaatttt gcatgtgcag 78240 cggagagctt gtcctttgtg ctctaaatcc ttgctacaaa cggttacata aaagatctaa 78300 gaaagtggag acaaaggaag gtgggtaaag ttagaaggaa aaaaagagct agaaaagtgt 78360 gcaagtcact tcatacctga attcttgaca tttgactgga attgttctga ttagaccatg 78420 gtcctcaagg catttcacag ttttttttaa gtctgcgctg ccttagggga ttttatcctt 78480 gagacatcca ctggcttaac tcaagtttcc ttcaaaatat gtagctaaat acagctgttc 78540 agctaatagc tcagaggttc tttggagaac aaatggaatg ttatttacta atattacttg 78600 tggcatgtta gcacttttgt gttctgccaa gtgcttttgg gtccattctc aaagccgcca 78660 tggctaagct ggtagtacgt tggcgatggc ccatatggga agtggaagtg gtagatcttc 78720 aggggacttt caaaatgctt tgaatttaac tctttcttcc cctttattct aattcctagt 78780 gggcaagtcc tgggccgacg ctgctttgag gcccggatct gtgcttgccc aggaagagac 78840 aggaaggcgg atgaagatag catcagaaag cagcaagttt cggacagtac aaagaacggt 78900 gatggtacga agcgccgtaa gtagatgtag tggccaaatg gggtagggtt gaatcttctc 78960 cagatgttgg agaatggggt gatattggag aagctgcatg ataagacctg tgaccttcag 79020 cagcaagtgg gacgtcagcc ctcagagcca gtgagaatag gtatagcatt gaagtggact 79080 ccaggcatgt actacagctt tacaaaaaca agtagtcatt gtgacaattt ctcagtccag 79140 ggattctcaa aatgtgactt ccacaccagt agcataaaca tcatctattc acagacacac 79200 accagcaaga tacgggcttt cctgcaacat tacttaagcc aaaggctatt tcccagcata 79260 ctgaatttct tttatgtatt cttccctacc atccttccac ctccttattg ctaggatcac 79320 aatcaatgta aaaacaattg tccccagtta aatggacgct tagggctaga gcctctaatc 79380 ttacatgtgt tgctggtact actgtctttt taatatgtat attaaatctg attaacatta 79440 atatttaatt attaagtata tttaatatgc attagtgctt tagaagtgtt cccaggatga 79500 aacttgcatt tttcctccac cagcgtttcg tcagaacaca catggtatcc agatgacatc 79560 catcaagaaa cgaagatccc cagatgatga actgttatac ttaccagtag gtcttccttg 79620 ggtgttcatg gttgcttcat tttaaccttc tttgaatggg cttttacagt atgatcatca 79680 tctcattatc tgtgacaatg ggaaaggagg tgtcttagtc agttgaagct gctacaacaa 79740 actaccgtag actagatggc ttataaacaa cagaagttta ttttctagag tctggaagtc 79800 tgagatcaag gtgcccctat ggtcgggttc tggtgagagt tctcttctga gttgcaaact 79860 gccattttct ccttgtattc tcatatagtg gagagggcta gagagctctc tagggtgttt 79920 tttttttttt tataagggca aaatcccatt tatgaaggct ccactctcat tacctaaatt 79980 acttcccaaa ggactcacct tctaatgtca tcacaatggg gttaaaattt ccatctgtga 80040 actttggaag gacagaaacc ttcagtccat aatggggaag aggggagacg gttgagagct 80100 ggtgatacaa aggagagaaa atatgtgttt tttaaaatta gaatattatt ctttctctcc 80160 acagttttgg actgtattac tagcatgagc ttctctactt acctacccac ccaactaaag 80220 ctaaactcct aacagaattt ttcttaccct aatatttaaa attaatttgt ccttcattat 80280 ttgagaatga taagattatc ctaggcagca tggccataga aatttaggcc gaaaatgttg 80340 tcagaaaaag ttcacaaaat tgataatgca gcaatgatag ccttgacttt gatgtctttt 80400 aggcagcact ataaagaaag ccaagcaagg cagaagcctg aattacagtc agccctccct 80460 atctgcctgt tccatatctg cagattcaac caatcacaga tcaaaaatag ttggaaaaaa 80520 acaataaaaa aatacaccaa tcaaaataat acaaatataa caacaatata gtataacaac 80580 taattgcatg gcatttacat tatattagat attataagta atctagaggt aattttaaac 80640 tatacagagg atatgcatag gttacgtgca aatactacac cattttatat aagggacttg 80700 agcaacctag gattttagta tccatggggg ccagatgggg gtgggtagtc ctggaatcaa 80760 tgctctgctg atatcaaaag acaactgtgt atgtaaatgg ccagaagtct tagcccaatt 80820 attatgtaag aacctcatta attcctacaa gggacattac ttctcttgca atcactaatg 80880 agatcacttt attagattat ggttgcagtt agttagttga attcttattg cattaggtct 80940 ttgccatgta gggtggcaat gacgttttgg tggctggcat agcccttgat gccatctaaa 81000 gcgatgacat gagacacagc caagcagggc caggagattt gaccatgaac tactaccctg 81060 ggattgaact aacgaaagtc aacggattta ggtgtgctgc actttcttcc tcatcttctt 81120 tgggtcctga ctctcagggg aataaattgc cagtagacca atcagacggt gagttagctg 81180 agattcccag tgtcttgttt ctcaaggtat atatggaaac tgacttgtga tgttaaagta 81240 aaacattacc ctgatacact aaatattcca aaagtcttaa tatgttttca gctgataaaa 81300 caggaactgc ttgaaaaatt attttaaaat ttcagtttgt actaagaagg aggtatcctt 81360 cttagtgtca tgtctcaagt tgagagaaga cttagcctaa ataatttatg ggtgaggaaa 81420 aactccatta atttaatata tattttgttg gtgtttggtg agtggcaaat atgctagacc 81480 ttgagcattt agagttcagt aggatacaat tcttactttc aactaccttg ccttctattg 81540 aggacacaaa cagttataat gtaataaata aatgtaatgt aataaaataa atattcctag 81600 atcaaggcct agtgctgtgt gagtacccaa gaagctccaa agatgcaaaa actataaata 81660 agagtaagat caagaaaagc ttctcagaga aggggtccca cagctgggat gagtaagagt 81720 taattcaaca aaaggtggag aacatttttc atttctgaat tctgactaat tctgcctttc 81780 ctactgggtg cagcaactgg ggtaaggcag ttaaagtgcc tagggtgcaa aatttaaata 81840 gtcactcaca cccaaggcaa tgcagttgtg ctaagtgcct ctcttgcctc actctagtcc 81900 tggcccggct catccgtttt tttggttttt gtttgttttg aaacaggatc tcactttgtt 81960 gcccaggttg gagtgtagtg gcaggatcat ggttcactgc agcctcagac tcccagactc 82020 cagcaatcct cccacctcac ctccccaggt agctgggacc acaggtgtgg gccaccacgc 82080 ccactaattt ttgcacattt tgtagagaag gagttttttt cccagggtgg tcttgaacta 82140 ctgagctcaa gcaatctgtt ccctcccaaa ttgccgggat tgtaggtgtg agccaccatg 82200 tctggcccct gctcataatt gtaaaagcct ttaagagctt ttatttaaag attttaaggg 82260 actctcttaa agagagaaac atattttatc ccacatggaa acttttatcc tatcaaacat 82320 agttacaatc tattcttatt ttttgtagta gtttagtttt atgaaggtgt tgcaaaaatg 82380 gtattggtgg atatgaatca tctcatcgct cctaagagaa atataggatt gggttcctat 82440 gcacctctgg tcacatacat ttcacaacag aataatatat cacttcgttt gttgtgtgtt 82500 tctgttaaga gacattttat ttaatatata ccgttgactc attaacatca gactcgtggc 82560 caattagcct tataactcat gcctgaataa agtttctcta acacacacac acacacacac 82620 acacacacac acatattttc tccataaggc atggaacgac cttctctcac ttagggacac 82680 tagatagcac ttccgcactg cccttgaggg tcttttaaat aacaaaatca ccaatgaaaa 82740 gcacaaaaat gtaaaacacg tggcgctaaa tagaccatga aaagaacgtg ggtttacggt 82800 ataagagcta caagatgaca gagcatctcc ttgttcgaac cagctgggaa tgcacacagg 82860 tgactcaaat ttttcatcac tctgcccggg tctgaaagac cacaaaaggg ccaagagtgt 82920 tgattttcat gttacaaata aacgttagca aataaacaaa ttgcaattac ggaatcctca 82980 aataatgagg attgaccaca cttctaacag ttctacagct tttcatgttt ccttctttcc 83040 ttctgctcac ttccataggt gaggggccgt gagacttatg aaatgctgtt gaagatcaaa 83100 gagtccctgg aactcatgca gtaccttcct cagcacacaa ttgaaacgta caggcaacag 83160 caacagcagc agcaccagca cttacttcag aaacagtgag tgtatcaacg tgtcatttta 83220 ggaggcatga gtgagggtga ctttatttgg atcagcaata gggtgattga tgagcaatgt 83280 ggaacataat gggagatagc agattgtcat agattcagat gacctggtat ggcaaccctc 83340 tttcagttgc aacctttttt acgtgtctta ttataacctt cccttcagaa ttccacttat 83400 gttctgaaat taaatacaaa ccatttctgg tgaattacaa agaaactcac actaacagtt 83460 ctcgtctcta tatgcctggt ccatacacac taacagtaag tacacactct atttggtagt 83520 gatgtgtata tttgaaaaca tgaaatcttt tctcatccca atggattgtc ttataaatct 83580 cctgggatgc acactatcca cttttgggaa taacactgta gaccagggat agcaaatagg 83640 ctttactata atataaagtg acttgtttga atgctgtaat gagaagaatt ctgagaccta 83700 gtgcatgata attggggaaa tatctgggtg cagaaggata aggtagcatc atgttgccgt 83760 attttagaat ctctgctcta gattgtcttc cagcagtaca tttttggcat aaatcaagcc 83820 agatttttca agtatattac catatacata taacctattt atatgttaag ctttgccttg 83880 aatcttggat ctttcctaaa gtgattttat gactgactag aatagaatag ctcttatgaa 83940 aggatgagag gttgaccaat caggaccttg tttatattta cctttctgtg gttaaaaata 84000 atcacttgtt agtttaatta aaatatgata tgtgtcctgg aagtattgtc agagactctg 84060 tagataagtg taaaatatat acattatgag tccacttgag taatgtagac tttcaacttc 84120 atactttagg caaaaaagaa gtcaaaaact atcttccaga ggcaaagatt atattttaca 84180 atagaaatgc aaatgaacaa taaaaatggt tattttctat gttattagct gttgtaggga 84240 gtcagctgtg gaaagtgtaa taaagagggc ttatgattat tattattatt attgagtctc 84300 gctctgtcac ccaggtagga gtgcagtggc actttcttgg ctcactgcaa cctctgccta 84360 gcgggttcaa gtgattctcc tgcctcagcc tcccgagtag ctgggattag aggcacctgc 84420 caccatgcct ggcagatttt ttgtattttt tagtagagat ggggtttcac catgttagcc 84480 aggctggtcg cgaactcctg aactcaggtg atccacccac ctcggcttcc cagagtgctg 84540 ggattacagg tgtgggccac cgtgccggcc ttgttattat gttttaatca atatgaatgt 84600 atctctgata gtaaagaaac actttctgag cacctgttat ctacagagtg gagtagacgg 84660 cagggagaaa agaggcacat tctctgttca aaggactcta agctatttga gcatccaaga 84720 tcctttttgg cccgaaggga tctcaccatt tacttttagc ataaaagttt tgcaaatttt 84780 aatggtatgg ttttatttgt aagcctgagc agaaagttta atcacacagt gtattctgaa 84840 ggagaattag aactcagagt tgcagacaca atttccattg ctaatcatat ggatgttttg 84900 ggatatcaga tggaaatata tactaacata tttaagtgga aaatgattta gttcttataa 84960 aaccatacaa ccaggatcaa agaaacagag acctgtaaca tcatttatag acccaggagg 85020 gatatctacc tttcctaaga tatgtgtgtc atggtattaa gaaataccct caaatttcct 85080 cctgttcact ctgaaagttt gactatacca aaatgacctc caaaacatca ctaagtaata 85140 tatcatgctg aactagttgc tcttcagtac tctttcctgt cttttttttt tttttttttt 85200 cagttaataa gaaaaggtct catatgtagt acaggaattg gcaagctgct ttttgtaaag 85260 tcctggtagt aaatatttag attttctggg tctatattgt cttttgcaac tactcagctc 85320 tgtggttgta gcacagaaac agccgaagat aatgcataaa ggaaagagag tggctgttcc 85380 ataaatggaa ctttatggac cctaaaattt gaatttcata taattttcac atgccgtgaa 85440 atattattct ccttttgatt gttcctcccc ctattaaaaa ctgtaggccg ggcacggtgg 85500 ctcacgcctg taatcccagc actttggtag gccaaggtgg gtggatcacg aggtcaggag 85560 ctcgagacga gcctggtcaa tatggtgaaa ccccgtcgct actaaaaata caaaaattag 85620 ctgggcaagg tggcacgcac ctgtagtccc agctacttgg gaggctgagg cagaagaatc 85680 gcttgaacct gggaggcaga ggttgcagtg agccaagatt gtgccactgc actccagcct 85740 gggcaacaga gagagacttc atctcaaaaa gaaaaagaaa aaaaaataca tacatatata 85800 tatatatata tatatatata tatatatata tatatataaa ctattcttag cttgctgtag 85860 tttgatagtc tgtcttatag ataaatgcgt ggatctcctt tcattgcttc ttgaggctcc 85920 aattttgttt gataggtgta cttggaagtt aatatgtata ttccaagcta gaaagttatt 85980 aaaagatttt aggaaatcct aaagtggttt ttcaggtggc atttcagtat ctaataaaaa 86040 gcaacaccag ccttgaacag atatcttttt tgtctgagaa agtgaggcat gcccatccag 86100 atataaaatg tagttaacga cacaacctca ttgtcagatg aggctggaat agttgacttg 86160 attcacgtca catattctta ttgaagatgt gctatgtgaa agcattaagg atagaggtga 86220 gaaagatgta gctcctgcct tcccatggtc tacaatttaa tggtgaattt ctaaccttaa 86280 cactctgagt ttgaagaaag ctctggaaat ttatcctcag cattgtgcaa gttaatagga 86340 caattttaaa cagtttccat ggatcatatg agaaaaagaa tagtttcatg tcattgtttt 86400 agaaacttga caagccagga ggattgacat cattcagttc aggggcatat gctaaatgta 86460 tttgttttta tggcatacat gaaaatacat aaccctcttt ttctatacga tgagtatcca 86520 gtgcttattg tctgaccggc tcacattgct ctaaagggaa ttttttattc atatttcata 86580 aaataatctg tgtccccaga gaagaaaaca catgttaata ttgtgttatt tttaaaagca 86640 cacaagattt tagggacata tttacacttt tttgcatgtg tggccacaga tagatagtaa 86700 agaactagta gcttcatagt tccctggtgt gttcatttaa ctgtattata tgcatgcttt 86760 tgagttggta tctcacagct gtgataactt gtgcatggaa atctaacaga ctgcaaaatt 86820 aaatctttgc aaaatataga catttggtct aattatgtct ttgtaacatt atatatacat 86880 gggtctccag tgattgatat gcatctatat aaatccttca gttgaattct tcagctgagt 86940 ttttttagct cttattttca tgcaaatctc caagaaagag catgaatgac taaacaaaga 87000 aaaacaaaaa tctaatttcc tggcaatcat ttgaaaagaa taaatcagct tggaaaatac 87060 ctataatagc ctgtgatttt ctttccaaaa agatagtacc aattttatgc tggtaaggaa 87120 tcaattttgt atttttcttt atagtagagg gaaaattagt gggaagagaa cgtactttct 87180 gtaaggtggc actacaatat ttttacttta attacttcta ttaggttccc actatgtgtt 87240 ttcttctgcc tgcttttcat ttgtgcatgg tttttctttt taaaaaaatt tcttcgcgtt 87300 taccttcatg atcataggct ttatcgaaga tagactttac agagctgctg tgaatcaaat 87360 tgttatagat acaagtaggc tttatattac gaagaaatgt gattttagtt gatttgctta 87420 cattggaata aatatagaga gttatgtttc tagatgccag aatctaatag aaagacaaat 87480 cggaccctat ctttagactt cttgccatcc tattatcaag ggacatcaac gcttaagaca 87540 gctttgcaga agcctcttga gacctattta gcaacgtttt gacttctgta cttcagatca 87600 gtactatttc ttttttcatt tgttagttgt tttcccttat tcttggcttc caacataaaa 87660 gcgaggctga catcactttg ttacagtctc gcttaggcta gctcttactt tcctctggaa 87720 atttattttt gagcttctac aggatgaatt ttatttaaat gataaaacag atctgtgaca 87780 tcctgatgag cccttagtgt ttccttctct tttatgatta cttgacaatt gtggctcatt 87840 agtaacacaa gtcagagatt attagaacaa agcaggatct ccaagtccat ggttccagcc 87900 cctcacacca tagccggata aactgaggct ctgtgaattt atagccagtt tataataaag 87960 ctaagactag aatcagattt agaacataga gctctttgta atgttgtgtt ctgctacatt 88020 ggcagttaag taagtagtta attataaaat ttaaacatct atttccattt ttctgtctct 88080 tttttgtagg attgttttag agatggggtc tagctatttt gcccaggctg gacttggact 88140 tctgggctca agcgatcccc tgcctcagcc tcccgagtag ctgtggacca caggcacacc 88200 ccactgtgcc tggcacgttt ttctgactct gttgttagtt acttggtatt tattcttgta 88260 ggttcacttt aaagtcctgt atctttaaac ttgtttggcg atggttatca tcaagaatat 88320 tgatattttt ttctcagatt catgtatctg agggagaagc aggcagtatt ttcagtatta 88380 tcaatgtaga aaagagaaag gtacacggtc tccaaactga tagaaaatgt caacaccgta 88440 tttctaggtt agacagagaa atcctccacg tttccagaat atctgaaatt gccagcttta 88500 taggttaaaa agagatgaat attgataatt tcatatgatt cacccttata gttattatgg 88560 aactacacaa gcttttacag tttccttttt tttttttttt ttttttgaga cagagtcttg 88620 ctctgtcacc caggctagag tgcagtggca tgatctcggc tcactgaaac atttgcctcc 88680 tgggttcgaa caactctcct gcctcagcct cctgcgtagc tgggattaca gatgcctgcc 88740 accatgcccg gctaattttt gtattttgat atatatatat aatttttttt ttcttttttt 88800 ttttttttag tagagacggg atttcaccat gttggccagg ctggtctcaa acccctgacg 88860 ttgtgatccc cccgaccttg gcctcccaca gtgctgggat tacaggtgtg agccaccgcg 88920 cccagcctac agtttacttt tgaatttcat agttatgaag ttttcagggc agagatttat 88980 tatctctgaa ttggtaatga agaaaaacca tagagacggg gtttcaccat gttggccagg 89040 ctggtctcaa acccctgacc ttgtgatccc cctgaccttg gcctcccaca gtgctgggat 89100 tacaggtgtg agccaccgcg cccagcctac agtttacttt tgaatttcat agttatgaag 89160 ttttcagggc agagatttat tatctctgaa ttggtaatga agaaaaaact caatgattaa 89220 ttaaactcag atagattaaa ttacttttgt aacttctctc acctcattgc agaatcaggc 89280 tcagtcctag gtcttagagg tctttagtta gctgtacatt gcttccccat ccatttttat 89340 tcgggcatat tctgttaaga tgatatcaat tcttgccggt gacatggttt actgaatcct 89400 agcattaagc aaataaaaat gactttgttc ctttgaaagg catagccaaa tgtgattcaa 89460 gaagccaatc tgggaaacaa tttccaaaca gttcatgaga ttgcccaact ttcagcaaaa 89520 taaaagggtt tatttctggc atcctcgtgg tgtaaataat ttcttaatta tgcaaaaaat 89580 tgctttcttg ggtttgatat atgcatttat aggccgagtt ttttactcaa aggattaagg 89640 tatttatcca tctcaatctg ggaatatcca aaatactcat taaacagttc tttgtaaatg 89700 cctgatgcca caggccccat tctgataata tcatatttct ctatacctca cacttaggct 89760 agacaagaac tgtaatgagg gataataatt gaccagatga cattttacaa aagattcaag 89820 tttcttcttc ttcattcctt ttttttaatt gagtccagta aaccgtatgc gaagcactgt 89880 gttaaatacc ttgatctacc ttatctcagt ggtcctcgac tgaatcgcct tgtgtaactt 89940 attaaaaata tgttttcctg gatgccagct tgtgttggaa gggagccagg aaaatgcatt 90000 tttataagtt tcacaagtga ttctgatgtt tatttctggt taactactat agccttatcc 90060 catttcttcc tcataaaaat cttgagaagt ctcagtaatt gtaaaagaag ataaattgga 90120 agaacaaaaa tagcttttca ggcactctat tctgtctata ctatgatcat gaaggtataa 90180 ggagtgtgtt tctgaattca attgatttga atagatgaag tcctaggcct tcattttttc 90240 ttttctctgg ttcctctctg cagtctcctt tcagcctgct tcaggaatga gcttgtggag 90300 ccccggagag aaactccaaa acaatctgac gtcttcttta gacattccaa gcccccaaac 90360 cgatcagtgt acccatagag ccctatctct atattttaag tgtgtgtgtt gtatttccat 90420 gtgtatatgt gagtgtgtgt gtgtgtatgt gtgtgcgtgt gtatctagcc ctcataaaca 90480 ggacttgaag acactttggc tcagagaccc aactgctcaa aggcacaaag ccactagtga 90540 gagaatcttt tgaagggact caaaccttta caagaaagga tgttttctgc agattttgta 90600 tccttagacc ggccattggt gggtgaggaa ccactgtgtt tgtctgtgag ctttctgttg 90660 tttcctggga gggaggggtc aggtggggaa aggggcatta agatgtttat tggaaccctt 90720 ttctgtcttc ttctgttgtt tttctaaaat tcacagggaa gcttttgagc aggtctcaaa 90780 cttaagatgt ctttttaaga aaaggagaaa aaagttgtta ttgtctgtgc ataagtaagt 90840 tgtaggtgac tgagagactc agtcagaccc ttttaatgct ggtcatgtaa taatattgca 90900 agtagtaaga aacgaaggtg tcaagtgtac tgctgggcag cgaggtgatc attaccaaaa 90960 gtaatcaact ttgtgggtgg agagttcttt gtgagaactt gcattatttg tgtcctcccc 91020 tcatgtgtag gtagaacatt tcttaatgct gtgtacctgc ctctgccact gtatgttggc 91080 atctgttatg ctaaagtttt tcttgtacat gaaaccctgg aagacctact acaaaaaaac 91140 tgttgtttgg cccccatagc aggtgaactc attttgtgct tttaatagaa agacaaatcc 91200 accccagtaa tattgccctt acgtagttgt ttaccattat tcaaagctca aaatagaatt 91260 tgaagccctc tcacaaaatc tgtgattaat ttgcttaatt agagcttcta tccctcaagc 91320 ctacctacca taaaaccagc catattactg atactgttca gtgcatttag ccaggagact 91380 tacgttttga gtaagtgaga tccaagcaga cgtgttaaaa tcagcactcc tggactggaa 91440 attaaagatt gaaagggtag actacttttc ttttttttac tcaaaagttt agagaatctc 91500 tgtttctttc cattttaaaa acatatttta agataatagc ataaagactt taaaaatgtt 91560 cctcccctcc atcttcccac acccagtcac cagcactgta ttttctgtca ccaagacaat 91620 gatttcttgt tattgaggct gttgcttttg tggatgtgtg attttaattt tcaataaact 91680 tttgcatctt ggtttatctt gcagtttttt tgtttctgtc tctctcactt tttttccact 91740 aaatactaga atattctcat gtaagtgctt gaagtagcat gtgtaggtct aaggaacaag 91800 aataataata gaatcatcac tttgttccta cgtacatttc ttctgtcagt atttggtatt 91860 tttatttaag atactctgta tcaaggtcat caatcgtaac aaggaactaa aatgcctaaa 91920 ctaacttaaa aaaatacttt agctctatga gttttaaagt ttgtcctagg aagccagaca 91980 ccatagaatc atttattgac attcctgaca aacctctagt tgtatgttaa ttcgccaaat 92040 ttactaaagt gaatttcaat caaatccaaa tgttttaaat aacatggctt ctgtggcata 92100 gacattagca aatatttggc cagaaatcaa cagtggaacc tattgtccaa tttttttttt 92160 tacttatgtt ttgagccctg aataattgct tttaaaagct tcataagaag ttctaaccaa 92220 aaaaaaaaaa ttagtatttt agataaatat ttcagaaaaa aaaatcttta tatttgagat 92280 aaaagtatat tagtaaaacc agatgctcct gttatatttg caaggtgttt ttcaattggt 92340 ctaataactt tgattcacaa agcccttaaa ggattggtga gtatgtttcg ttttttgata 92400 tttgcttttc tttcagaagg gtttttcttt tctttcagcc ttttttaagt aagtttttaa 92460 tgtgtttata gtgacttgta tataaatgca catatttgaa atgatggaaa atattagaaa 92520 attacagttt tcccatctag agaataaatg ctgcactgtc tttagtagcc agataacccg 92580 gctagagaga aaggtcacag gtaggcagta ctgggtaaaa ttgagagaag atatgattct 92640 ttttctgatg gtccatgttt tccctttttt tttttttttt cctgaccttt ctcataacaa 92700 ggatgctctg ctccgccctc agtatccctt tctgctccca aattctttac tgcagaaatg 92760 gtttgttgaa atagatttgg cctaagctat caccaaatcc tactagaggg ttgcttttta 92820 atgagcagtg gaagatttta gccaaaagaa ggaatctagt ggaattctag acatctagga 92880 ggtagatagt gtaacttgtg tctgcgcagg aattttgata ttctaccaca tagatagtca 92940 ctagggttgg aaccagaaaa cctgatttga agtcctatat gtcctaaaac cacttctcgc 93000 ttttcaattt tgaattttat tcttcggaaa ctgtgcagaa gcttatattg ttaaagttaa 93060 gaactgggac ttggctccac caggattttt cttcaaagct ggaaatacgt gaaatatgat 93120 tttctacatc tctgttacac tgaattctta gaaaaatcta gtgaggctct agagaaaaca 93180 acctgaggta tacaccttac gatttttttc tgcagacagc tggattctta cttttttggg 93240 ttttggatag gagaggagag tgtaggcaag aaaaccagaa tggtacaggt cctgttattc 93300 ttctgaacac attttccttc tctttagttt ctccagaaat ttttggaata tttcacttaa 93360 gaactattgt attaaatttg taattttttt taaaaaaggt tgttcttcaa ggctttcaaa 93420 ttggctgagt ttattcagcc ttgcttcctt tttcaccgta tgtagttttc agaatgcttc 93480 ttctagttca gtcattttga aattaataat agacagacta ccttgcttcc cttccgtgtg 93540 gctttaaaac tcactttcat attaaaggga aggcattccg aatttctgac ctttcctgac 93600 tgttaacccc attcaactgt tcaccctcat ttctgggtat gttcaattaa gaatccaact 93660 cacctctggc cacttcctcc tattaattct tacatagtta tcttctatgc catgggccac 93720 atatcagagt gttaaatatt tgaggctgga gggaaacagt gaaagaagct aagaagctga 93780 tgtttcctga gcacctacaa atcactggac cctgtccagg gctgttacat gatctcattc 93840 ttaatagaaa tcttctagag taggtacaat atctaggcta caggttaaga aaatgagact 93900 caagaaactt gtacaacatc ctgcgtcact aagtttgtgt tagatgtttt gattgactta 93960 gaatccatgt tccttctttc ttcatctgtg gtttctgacc taccctcctc aaattagtgg 94020 cttatgatga aaaatggtaa atgaactaat aaaatagtca aaaataataa ccataagcta 94080 aagaaagcag gaggttgtaa caggaattgt aagaaggaat ttactctgag cgtccagaaa 94140 aaaaaaaaag caaaactttt aaatgtattt ttatttttct aattgtggct attaatgatt 94200 caagcactgc tttctattag ctcttgctgt acatttgact ggtttgagga gggacagata 94260 gagaggtctc ctcaggttac agaggaccaa ctgcatcagg aatatgggct acctggaatc 94320 ttaggtactt ttcagtgagc aaagagaatt gaagaaacat cagctggcag agaatctcct 94380 tactgccttg ccccaagctt tcctatactc tgatgtggac taatggatga gcctaagtgc 94440 agccatatgt gctgactctt tgaaaaggtt cccccacagg gacggagtgg attcagaagt 94500 gcttggtagt agctggagtt acctccttta cccctcttcc atcttggtct cctacatttc 94560 tcttactact tcatctattt cttgtcccca taacctagaa aaaacaatag gtgccaggag 94620 acctagttct gccctcagtg catccattta gcaacatgtg atcttgggca tatgtttttt 94680 cttagaacct tatatttacc catatgtata tttggaatag taatttctgt ccatctctgc 94740 cctgctatac catgacctgc tccacaagga tggtgtgaca atcattcaga aaatgtacaa 94800 agaagagttc ggtaacctga aatgttttat agttgggagg atttattgta tcaacaccag 94860 tatatatata caatgtggat ctataattgt gagtatttga taagggctaa agagaaaagt 94920 caatgccctc ctaccttaaa ggcagtgatt gtaaaataca cctgaattgt taatttacat 94980 taattgacat gataatttat acacattaaa atacagcata ttgtttgcat tcatctagct 95040 gtggctctcc attgacatgg aatggagcct tccttatttt catgtaatta tggagagaat 95100 gcagagtggc agcttcgaag accatcccta cgattgcagc acctaagtgc tagggccatt 95160 tttaaaatga tttttttcaa atattatgcc atataggctt ggaacctggg tccatttaca 95220 gagcctccaa aatttgaatt atacatatat atgcagataa aactcaaaga aaaaatttgt 95280 ctcccctcta atgtaaatat gcctgtgaca gggaaaaggt aaacaggaac aacataattc 95340 gctttgtttg agaattgtta aaggggagtt ttcccataac agactagaca cttgcttaaa 95400 gtccagtctt cattctgtgg tcacagtaat tcagtgtaga tgctgcatag tctgtacatt 95460 tcttcctcat cttctctttt tcagttctca tcatagccgt ataaggtagg atggattatt 95520 atatccattg cctccactac tctatgagtg tctcaaagat ggggaccatg ccttaagttt 95580 tattaacttg aacatctgac tcatgcagca agtgtaaatg tatgtagttt atatagtttt 95640 cttgtgagaa aacaaaggcc aggatgttaa gtagctcgca tgggcatcta tagcatccta 95700 acagatgacg gaggaaggct tcatctctga ctttgtgact ctcattgtag tacacatcac 95760 tagtttttat attaagataa aacatcagga atgacagttg agttgggaat attatctgtt 95820 agatataata tgacaaatga gttctggtaa ctttccaaat tgaagatcat gctgaatgga 95880 aaactattgg gtttttctgt tgctttgttt ttttcatttc tcccaggaga cttttggaaa 95940 gtcaatagaa tagttatttg ggcttcagcg ttctcctgtg tagaaatgct tttgacattc 96000 cagtaggttc tctcatacat catgaacatc tctattgaaa atgcatgttt ccaagtaggg 96060 gcctctgcat gacagcaaga tgagctgcca aatgcccagt ttgattgggt ttgtagtcat 96120 tttctgcata tcccaaatgg aatatacaga aagctacaaa tggaatgcct tagctgcagt 96180 ttgagggtgg gatatccatg tttttcgtca gcctttaagt ctttgctcaa ttcttttccc 96240 taactgcttt tcaaactcat ttgagttgaa gggaaaagag gagaagggaa tggagaaaac 96300 aactgaaggg aaaagaggag gcaagaattt tctctttctc aaaggaaata ctaaaccttg 96360 cactctgcac attcaggaaa aatatgattt gatgatagcc tcgcagtcag tttctcccta 96420 ttcaggaaat attctcagat ggaaacaaaa ttaacttctt accattaatc ctagaagaat 96480 gttttcaaat gtttggtttg aggccatgtt ttaaacagag acctgttgaa aatcaatagt 96540 ccccactctt cagtgtccct tgctcaccat tatttccatg tttgtcttcc taggacctca 96600 atacagtctc catcttcata tggtaacagc tccccacctc tgaacaaaat gaacagcatg 96660 aacaagctgc cttctgtgag ccagcttatc aaccctcagc agcgcaacgc cctcactcct 96720 acaaccattc ctgatggcat gggagccaac agtaagagca tctcctttta gctgtggctg 96780 aaggatgaac aggctagctt aggacaagac tctgtgatgg ggaaggcatg ttcttaagct 96840 aaatgagaga cacagtggga cagatcagat caaagtggag tggcttgggt ttctgactga 96900 acctttcact tttgaggttt atcattcatt gcaaaatata ctactggtag agatagggac 96960 ggatgtttct ttagtgtagg gataaggatt tctgtgaaaa gaacagtcta cttgctgcta 97020 tcctggatgg agactcacca cctgcagcct ttgaaatagt caaaaggaaa caaatgcaac 97080 atgcataaag tagcatgttg cagtgaactt aaaatctaga gaaataggcc gggcatggtg 97140 gctcacgact gcaatcctag cactttggga ggccgaggcg ggaggatcac ttgaggtcag 97200 gagttcgaga ccaacctggc caacatggtg aaaccccgtc tctattaaaa atacaaaagt 97260 tagctgagcc tggtggtgca tgcctgtaat cccagctact caggaggctg aggcatgaaa 97320 atcacttgaa cccgggaggc agaggttgca gtaaggtgag atcacactgc tgcactccag 97380 cctgggtgac agagtgagac tcagtctcaa aaaaaaaaaa aaaaatctag aaaagtagat 97440 tatcgtctgg actctatgaa aaaaatacct ctaattacaa agaagttact tctcgaatac 97500 ttaattttct atccataaaa ttgtcactat atatacttaa cattttatgt ctgttactct 97560 ataatcctgg ccttttaaac tcacctattc tatcccagac acagtcagta aggaactgat 97620 ctacgaagga acctgccttt tatttcttct cacacacatt cctcatatca gctaagtaca 97680 aatgaaaaag gcactgtaag aattgggcct ccaagtggat gatgactggc atatagcttt 97740 actataaata taattatctt ctccactagg actaaatcta gcaaagtgga tacacaaact 97800 tgaaggaaaa aaaagtcgtg gtaaaaatgc aaaagattgt ataacaccct cggggataca 97860 gaagactgaa cattgcatgg gtatcatata atccttacta cctaaaaaac agtaccctca 97920 agcttgtctt ttgaaatcct aattattttg atcaaacctc taaacgagca tttcagtgtt 97980 gtctcttctg aaagaaatca ggggaggcta ggattatgac tttctgtggt ctaatggcac 98040 acattcattg ttttggtttt tttttttttt ttttagacag agtttcgctc ttgttgccca 98100 ggctggagtg caatggcgca atctcggctc actgtaatct ctgcctccca ggttcaagtg 98160 attctcctgc ctcagcctcc cgaatagctg ggattacagg cgtgcaccac cacgcccggc 98220 taattttttg tatttttagt agaggtgggt tttcaccatg ttggccagac tggtcgcgaa 98280 ctcctgacct caggtgatcc acccacctca gcctcccaaa gtgctgggat tacaggcgtg 98340 agccaccgcg cctggccaca cattcatatt ttaatgagat agaggtgtgt gtgtttgcaa 98400 tggttgcctg ttatggcaaa cgtagacttt agagtgagat cactctctca ctaatgataa 98460 actcatcata aggcttaaaa cctgacccct tgacaggcct actttgacat aaaaagagta 98520 gaaaccattt attttcaact ttattttatt tcttgtgaca tcttagagtc ctcaagttcc 98580 ttcttggtat gacaaaattg tgataatagt gatgatggtt cacatttgta taacttacag 98640 tttgcctact ttttttctta tttgtacttt acaattattt cagaagggaa acagattgag 98700 atgtgatagg gtatgctctt tagttagcta gttagtggca aagacctttt ctaggcatac 98760 tgctactcac taaagtagaa acaaattaca ttaatctttt agtaaattat tttgttcttt 98820 ttgacatgaa ggcaaaattc attttataaa tattgatatt aaactttttt tctctatcag 98880 tgagtgttta cacttaattg tttagtaaaa tatcagtaag tattggtggt gttcctgtat 98940 acaaccctga aaatggacca taagtaatag aatatttaat tgtatcatca tttattaggc 99000 acgtgagtcc ttctaaatat tgaagtcagt ctccctattc ccaaataaat gttccaaggg 99060 tcactctttc attcacagat ttgtgcattt atccacttac cctaagttta ctgagcacct 99120 actctgtgcc aggcactgtg ctagggactg tagggatcta gacacctata agatctaatc 99180 tctgtgcttg cacaggttag tgagggagac agaaatatca ccctcgaagg caaatacaag 99240 gaagaatatg ttaacattaa gagcaattag caattagaga attagaagca gagaaagggg 99300 aggaaagaga ttgttctcgg acaaggtaca aaagtcaaga ggtgcctaat tagtttggag 99360 tctgaccgtt ctgtttgact agatgtaggc tgtttgaagg ggtgtagtga gagcgaagat 99420 taaaaaggaa ggctggtagt ttaggccctt gataaaattt aaccagacaa gatggaccac 99480 tgggatgctg gtacatgatg atggcagtaa ccctttttgt tcctcctgct tctgttcagt 99540 tcccatgatg ggcacccaca tgccaatggc tggagacatg aatggactca gccccaccca 99600 ggcactccct cccccactct ccatgccatc cacctcccac tgcacacccc cacctccgta 99660 tcccacagat tgcagcattg tcaggtgagt ccacagcatg tgcccctggg ggcctgccct 99720 aagcatcccg ggatggtgga gggcggatac tgttatagtc cataaaacag ttggaaggga 99780 agacagcagt cctgtggttg gagttcagtc actattatct ctgatctgtg gagtggtcaa 99840 caatgtttta tcaaggaaaa ctactataac cagcatggaa acaagggaaa gtgtctgttg 99900 ataggcatat tgttttcatg tctgtttccc tcgccttcac ttactccctt cctcctctct 99960 cacattttta cattgtcaat tgcggccctc aagttggtgc tcagggctgg gtttccaaaa 100020 gggcaataaa cttgctatct cgctcctttt cctctctctc taatccttat agctctcagc 100080 caccatggga ccattatttt ggagttggat gtccataaaa agttttaatg ttatccaaaa 100140 tgacagggac tttcaaaaac tgatggcctt tactactctg cctatgggaa atgggcacac 100200 tccagaaaag gggagttgag ataagcagaa gaaagaaatg catgaagcct gaaagatttg 100260 cttcccacag aggcaagagt aggttcccag atttcttgcc tagtgtatat cttcttcttc 100320 tgcttcatgt gcagaatgat tgtttcattt ggctactgga acgatttgtg ttgattttcc 100380 tgctacgtca atcacaggga tggcaaagtg cgtggccttt tccacccagg gtctgttctg 100440 taatgatggt ggcatcatca tcagtctcag accagcacca aaaggaaggg gatctgtatc 100500 ctgagaagga cataaatcaa aaggcatgaa tgacttaatg gagtagaggc ctacaatttt 100560 tttcttaacc acatgagcca ttctcacaaa gcccagatac aaaacaaata aagtagagat 100620 gttctttttg aagtgtagag ccaagcagca agaaagctag gaacctgaac actggacttc 100680 cctttcaccc tttgcaatgg ttcctaggac acttacacag aaccctagaa ttccacagat 100740 caccatatga taatcgctga tctgcaggaa tccttatagt tgattttaat ttctgtagac 100800 ctaaacttca tgtcaccagt aatctccaga cctcagactt aaggcccaca tatatattac 100860 ccaatcctca tctctgatgt ggggcatcca agggcaaaat atattgggtt ttcccttatc 100920 tcgccaatgc agttggggtg aactttcttt ttctgtttcc tccttcctct tccctcctcc 100980 ctctgcagtt tcttagcgag gttgggctgt tcatcatgtc tggactattt cacgacccag 101040 gggctgacca ccatctatca gattgagcat tactccatgg atgtaagtaa ctgttagact 101100 tttctcaaat tttatttctt catttctttc ctctgatgac aaccgccttg tagttcaatc 101160 cctgatagtt taaaaatttg tttttgtcat gcccccaatt atccattttg atagaaccca 101220 taactatgtt agaaagattc ccaggcctca acctatacat attagaagct tagcaatcaa 101280 tcttccttag cttgtcttat cagtcaacaa ttgtctattg cacttacact attctcaagg 101340 tgggaaagag gagctattcc cgcaatcaaa acattcataa tttctaaaga attaatacaa 101400 ctttttgagt gtgctcatta atctgtatca gttcccagaa aggatagcag ggcaccggtg 101460 gtgctattct cttaaaaaca tggagagatg acacagtagt catttgccat gactatttaa 101520 aacaaaacta ggaatagaac acaaacgtgt aagcttacag tctttaactt tattaactgg 101580 ccttttctgc ctttctttaa attagtacct taagggagat tcagccgttc ctctcaatta 101640 aaactatatg ttcctttatt aattttcagt ttcatcctaa tagagcccag ccatttctaa 101700 tcattgggca ttatcaatgg ctatggggtc aaatcccaat cacccttttt agtagcaatg 101760 agaacttggg gttatcactt tgcctctctg ggcctcagtt aataaaatat tgggttcaaa 101820 ttactccttt ctggctttca tatcctttga tttgtctttg aaacaagctg ggcgagaggg 101880 gactttttct tgcttcctac tccacttttt gaactcctgc tcacacggga gctagtgttg 101940 ctctggttta tggcaatctg atttgtctct taggccgcgc tcttcatgct gctctctttg 102000 gggttcacta gcctctcttc tagcttccag agggtacttt ggactgcggg aagaagacag 102060 tctctgcctc tgctgctact tctattgttg gggactcttt tttccccctc cttgagcacc 102120 gatgctagag atgcccctgc agcataagaa tgcccccacc atgaggtgac gtgtacatag 102180 tgtactgccc ctatgcccac ccctcttcac cccataaatc actcctggct gctgctccct 102240 gatagaataa gttataagca aaaactgcag ggaaagcttt aagagtaagt tccagtatta 102300 ttctgataac tttacagtca cttccgtcca ctgaagagaa cagagttgcc ctatatttga 102360 gagagtctcc tgtagtagat tcctacattt tggaacagag aatcttcctc ttccctatat 102420 ttttaaagtt atactttcca cttgctcact tatttccact ggggaatgtg tcaggatgtt 102480 cccttgatca ttaggatctg cagataccct ttataagttc atttctgctg atgttgacta 102540 agtcctatgc caatctgtgg gccacagctt tctcacctgt cagtcattag ttaaaatcca 102600 tccagggcat catgacaatg aacagagtct aatttacaaa gagctttgca tttactgaga 102660 gcctcaaaag tataaagaat ccaagaaaca taaaaagcta tgcttattta ggccgggcat 102720 ggtggctcac acctgtaatc ccagcacttt gggaggccga ggcaggcgga tcacgaggtc 102780 aggagaccga gaccatcctg gctaacacgg tgaaaccctg tctctactaa aaatacaaaa 102840 aattagccag gtgtggtggt gcacctctgt agtcccagct actcaggagg ccgaggcagg 102900 aaaatggcgt gaacttggga ggcggagttt gcagtgagcc gagatcacgc cactgcactc 102960 cagcctgggt gaaagtgcaa gactccgtct caaaaaataa taaaaaaagc tatgcttatt 103020 tttttgtgga ttaccttctt tataaggtat tcttctgcta cagtaagaga ttaggaatac 103080 ctctaatggc ctgaaaattc acaccatagg aaaatatgac accagactac aaacttccaa 103140 attgagaaat gttgggaagc tgtgcaattt tctcctcctc acctcagctt cttcctgcgt 103200 atttctagaa agagacaccc ttttctcagc ttttatctta gagccagtct aagttattgg 103260 gcatcatcac ttcctggaaa aggaatgtga cctaaatttg gggaacttca ttagtatccc 103320 cataacatgc aaaaatgagg taacaataca acataataat aatacaaatg gttaatattt 103380 atagagtgtg ttgtaattta taaaatactt tcatagctgt atttacctat gagtctatag 103440 catcttttgc cctataaagc aattgtatct cattttacca aagaagaaac tgaggctggt 103500 agagaataag tgacttgctg aagttctata gccagtcagt gaccatcaaa acctctgcca 103560 cagttttctc actccaagca caatgtgctg tttacctacc attctgccct gtgaaaatat 103620 gagctatcac tgaaacaatc taaagaagag ctaacgcaga taaatgtaag tgatatcacc 103680 acagtcagtt aaggttgacc ctatttgcaa tgccttctgc acccattcac agaacataga 103740 cacagttgct ctgcattttg ataccttgct ttattcaaac accaagagac cttttagata 103800 aaagtgccgt ttcaggttct gaggatgccc taagtcccta attttttcac ttagttatgt 103860 gactttaaac ttgtcaacct ctctggcctt cagttgttct atctataaaa caggtctaat 103920 aatgtttacc actaatctgg ggattaaatg atatcatgaa tataaaataa ttcagggcct 103980 ggcacataga aagtactcaa tcttttcttc tcatctcctc aaccaagtgg tggtgacatt 104040 ccattaatac ctttcttcta gtgactagcc aggtaaattc aagcataagt aggtacctca 104100 tgtttctatt tgggattttt gccctctcat ctagctatta tcccaatttt accaatgaag 104160 aaactgaggc cagtagagac taagtgaagt gttctacaca ggcaggaaag acacctcaag 104220 gctgtgcctt tgtgcttagt tccatagagt tgaagactca gagaactaat tttattttct 104280 aatttgtgga tcaatagatt cagatcaatt aaaccagagc atcagggaat gataggatgc 104340 tgtggactaa atgtccgttt ttctccctgt tttcattctc catgacacct tcccctgttg 104400 cacaggatct ggcaagtctg aaaatccctg agcaatttcg acatgcgatc tggaagggca 104460 tcctggacca ccggcagctc cacgaattct cctccccttc tcatctcctg cggaccccaa 104520 gcagtgcctc tacagtcagt gtgggctcca gtgagacccg gggtgagcgt gttattgatg 104580 ctgtgcgatt caccctccgc cagaccatct ctttcccacc ccgagatgag tggaatgact 104640 tcaactttga catggatgct cgccgcaata agcaacagcg catcaaagag gagggggagt 104700 gagcctcacc atgtgagctc ttcctatccc tctcctaact gccagccccc taaaagcact 104760 cctgcttaat cttcaaagcc ttctccctag ctcctcccct tcctcttgtc tgatttctta 104820 ggggaaggag aagtaagagg ctacctctta cctaacatct gacctggcat ctaattctga 104880 ttctggcttt aagccttcaa aactatagct tgcagaactg tagctgccat ggctaggtag 104940 aagtgagcaa aaaagagttg ggtgtctcct taagctgcag agatttctca ttgactttta 105000 taaagcatgt tcacccttat agtctaagac tatatatata aatgtataaa tatacagtat 105060 agatttttgg gtggggggca ttgagtattg tttaaaatgt aatttaaatg aaagaaaatt 105120 gagttgcact tattgaccat tttttaattt acttgttttg gatggcttgt ctatactcct 105180 tcccttaagg ggtatcatgt atggtgatag gtatctagag cttaatgcta catgtgagtg 105240 acgatgatgt acagattctt tcagttcttt ggattctaaa tacatgccac atcaaacctt 105300 tgagtagatc catttccatt gcttattatg taggtaagac tgtagatatg tattcttttc 105360 tcagtgttgg tatattttat attactgaca tttcttctag tgatgatggt tcacgttggg 105420 gtgatttaat ccagttataa gaagaagttc atgtccaaac gtcctcttta gtttttggtt 105480 gggaatgagg aaaattctta aaaggcccat agcagccagt tcaaaaacac ccgacgtcat 105540 gtatttgagc atatcagtaa cccccttaaa tttaatacca gataccttat cttacaatat 105600 tgattgggaa aacatttgct gccattacag aggtattaaa actaaatttc actactagat 105660 tgactaactc aaatacacat ttgctactgt tgtaagaatt ctgattgatt tgattgggat 105720 gaatgccatc tatctagttc taacagtgaa gttttactgt ctattaatat tcagggtaaa 105780 taggaatcat tcagaaatgt tgagtctgta ctaaacagta agatatctca atgaaccata 105840 aattcaactt tgtaaaaatc ttttgaagca tagataatat tgtttggtaa atgtttcttt 105900 tgtttggtaa atgtttcttt taaagaccct cctattctat aaaactctgc atgtagaggc 105960 ttgtttacct ttctctctct aaggtttaca ataggagtgg tgatttgaaa aatataaaat 106020 tatgagattg gttttcctgt ggcataaatt gcatcactgt atcattttct tttttaaccg 106080 gtaagagttt cagtttgttg gaaagtaact gtgagaaccc agtttcccgt ccatctccct 106140 tagggactac ccatagacat gaaaggtccc cacagagcaa gagataagtc tttcatggct 106200 gctgttgctt aaaccactta aacgaagagt tcccttgaaa ctttgggaaa acatgttaat 106260 gacaatattc cagatctttc agaaatataa cacatttttt tgcatgcatg caaatgagct 106320 ctgaaatctt cccatgcatt ctggtcaagg gctgtcattg cacataagct tccattttaa 106380 ttttaaagtg caaaagggcc agcgtggctc taaaaggtaa tgtgtggatt gcctctgaaa 106440 agtgtgtata tattttgtgt gaaattgcat actttgtatt ttgattattt tttttttctt 106500 cttgggatag tgggatttcc agaaccacac ttgaaacctt tttttatcgt ttttgtattt 106560 tcatgaaaat accatttagt aagaatacca catcaaataa gaaataatgc tacaatttta 106620 agaggggagg gaagggaaag ttttttttta ttattttttt aaaattttgt atgttaaaga 106680 gaatgagtcc ttgatttcaa agttttgttg tacttaaatg gtaataagca ctgtaaactt 106740 ctgcaacaag catgcagctt tgcaaaccca ttaaggggaa gaatgaaagc tgttccttgg 106800 tcctagtaag aagacaaact gcttccctta ctttgctgag ggtttgaata aacctaggac 106860 ttccgagcta tgtcagtact attcaggtaa cactagggcc ttggaaattc ctgtactgtg 106920 tctcatggat ttggcactag ccaaagcgag gcacccttac tggcttacct cctcatggca 106980 gcctactctc cttgagtgta tgagtagcca gggtaagggg taaaaggata gtaagcatag 107040 aaaccactag aaagtgggct taatggagtt cttgtggcct cagctcaatg cagttagctg 107100 aagaattgaa aagtttttgt ttggagacgt ttataaacag aaatggaaag cagagttttc 107160 attaaatcct tttacctttt ttttttcttg gtaatcccct aaaataacag tatgtgggat 107220 attgaatgtt aaagggatat ttttttctat tatttttata attgtacaaa attaagcaaa 107280 tgttaaaagt tttatatgct ttattaatgt tttcaaaagg tattatacat gtgatacatt 107340 ttttaagctt cagttgcttg tcttctggta ctttctgtta tgggcttttg gggagccaga 107400 agccaatcta caatctcttt ttgtttgcca ggacatgcaa taaaatttaa aaaataaata 107460 aaaact 107466 <210> 2 <211> 586 <212> PRT <213> Homo sapiens <400> 2 Met Leu Tyr Leu Glu Asn Asn Ala Gln Thr Gln Phe Ser Glu Pro Gln 1 5 10 15 Tyr Thr Asn Leu Gly Leu Leu Asn Ser Met Asp Gln Gln Ile Gln Asn 20 25 30 Gly Ser Ser Ser Thr Ser Pro Tyr Asn Thr Asp His Ala Gln Asn Ser 35 40 45 Val Thr Ala Pro Ser Pro Tyr Ala Gln Pro Ser Ser Thr Phe Asp Ala 50 55 60 Leu Ser Pro Ser Pro Ala Ile Pro Ser Asn Thr Asp Tyr Pro Gly Pro 65 70 75 80 His Ser Phe Asp Val Ser Phe Gln Gln Ser Ser Thr Ala Lys Ser Ala 85 90 95 Thr Trp Thr Tyr Ser Thr Glu Leu Lys Lys Leu Tyr Cys Gln Ile Ala 100 105 110 Lys Thr Cys Pro Ile Gln Ile Lys Val Met Thr Pro Pro Pro Gln Gly 115 120 125 Ala Val Ile Arg Ala Met Pro Val Tyr Lys Lys Ala Glu His Val Thr 130 135 140 Glu Val Val Lys Arg Cys Pro Asn His Glu Leu Ser Arg Glu Phe Asn 145 150 155 160 Glu Gly Gln Ile Ala Pro Pro Ser His Leu Ile Arg Val Glu Gly Asn 165 170 175 Ser His Ala Gln Tyr Val Glu Asp Pro Ile Thr Gly Arg Gln Ser Val 180 185 190 Leu Val Pro Tyr Glu Pro Pro Gln Val Gly Thr Glu Phe Thr Thr Val 195 200 205 Leu Tyr Asn Phe Met Cys Asn Ser Ser Cys Val Gly Gly Met Asn Arg 210 215 220 Arg Pro Ile Leu Ile Ile Val Thr Leu Glu Thr Arg Asp Gly Gln Val 225 230 235 240 Leu Gly Arg Arg Cys Phe Glu Ala Arg Ile Cys Ala Cys Pro Gly Arg 245 250 255 Asp Arg Lys Ala Asp Glu Asp Ser Ile Arg Lys Gln Gln Val Ser Asp 260 265 270 Ser Thr Lys Asn Gly Asp Gly Thr Lys Arg Pro Phe Arg Gln Asn Thr 275 280 285 His Gly Ile Gln Met Thr Ser Ile Lys Lys Arg Arg Ser Pro Asp Asp 290 295 300 Glu Leu Leu Tyr Leu Pro Val Arg Gly Arg Glu Thr Tyr Glu Met Leu 305 310 315 320 Leu Lys Ile Lys Glu Ser Leu Glu Leu Met Gln Tyr Leu Pro Gln His 325 330 335 Thr Ile Glu Thr Tyr Arg Gln Gln Gln Gln Gln Gln His Gln His Leu 340 345 350 Leu Gln Lys Gln Thr Ser Ile Gln Ser Pro Ser Ser Tyr Gly Asn Ser 355 360 365 Ser Pro Pro Leu Asn Lys Met Asn Ser Met Asn Lys Leu Pro Ser Val 370 375 380 Ser Gln Leu Ile Asn Pro Gln Gln Arg Asn Ala Leu Thr Pro Thr Thr 385 390 395 400 Ile Pro Asp Gly Met Gly Ala Asn Ile Pro Met Met Gly Thr His Met 405 410 415 Pro Met Ala Gly Asp Met Asn Gly Leu Ser Pro Thr Gln Ala Leu Pro 420 425 430 Pro Pro Leu Ser Met Pro Ser Thr Ser His Cys Thr Pro Pro Pro Pro 435 440 445 Tyr Pro Thr Asp Cys Ser Ile Val Ser Phe Leu Ala Arg Leu Gly Cys 450 455 460 Ser Ser Cys Leu Asp Tyr Phe Thr Thr Gln Gly Leu Thr Thr Ile Tyr 465 470 475 480 Gln Ile Glu His Tyr Ser Met Asp Asp Leu Ala Ser Leu Lys Ile Pro 485 490 495 Glu Gln Phe Arg His Ala Ile Trp Lys Gly Ile Leu Asp His Arg Gln 500 505 510 Leu His Glu Phe Ser Ser Pro Ser His Leu Leu Arg Thr Pro Ser Ser 515 520 525 Ala Ser Thr Val Ser Val Gly Ser Ser Glu Thr Arg Gly Glu Arg Val 530 535 540 Ile Asp Ala Val Arg Phe Thr Leu Arg Gln Thr Ile Ser Phe Pro Pro 545 550 555 560 Arg Asp Glu Trp Asn Asp Phe Asn Phe Asp Met Asp Ala Arg Arg Asn 565 570 575 Lys Gln Gln Arg Ile Lys Glu Glu Gly Glu 580 585 <210> 3 <211> 1761 <212> DNA <213> Homo sapiens <400> 3 atgttgtacc tggaaaacaa tgcccagact caatttagtg agccacagta cacgaacctg 60 gggctcctga acagcatgga ccagcagatt cagaacggct cctcgtccac cagtccctat 120 aacacagacc acgcgcagaa cagcgtcacg gcgccctcgc cctacgcaca gcccagctcc 180 accttcgatg ctctctctcc atcacccgcc atcccctcca acaccgacta cccaggcccg 240 cacagtttcg acgtgtcctt ccagcagtcg agcaccgcca agtcggccac ctggacgtat 300 tccactgaac tgaagaaact ctactgccaa attgcaaaga catgccccat ccagatcaag 360 gtgatgaccc cacctcctca gggagctgtt atccgcgcca tgcctgtcta caaaaaagct 420 gagcacgtca cggaggtggt gaagcggtgc cccaaccatg agctgagccg tgaattcaac 480 gagggacaga ttgcccctcc tagtcatttg attcgagtag aggggaacag ccatgcccag 540 tatgtagaag atcccatcac aggaagacag agtgtgctgg taccttatga gccaccccag 600 gttggcactg aattcacgac agtcttgtac aatttcatgt gtaacagcag ttgtgttgga 660 gggatgaacc gccgtccaat tttaatcatt gttactctgg aaaccagaga tgggcaagtc 720 ctgggccgac gctgctttga ggcccggatc tgtgcttgcc caggaagaga caggaaggcg 780 gatgaagata gcatcagaaa gcagcaagtt tcggacagta caaagaacgg tgatggtacg 840 aagcgcccgt ttcgtcagaa cacacatggt atccagatga catccatcaa gaaacgaaga 900 tccccagatg atgaactgtt atacttacca gtgaggggcc gtgagactta tgaaatgctg 960 ttgaagatca aagagtccct ggaactcatg cagtaccttc ctcagcacac aattgaaacg 1020 tacaggcaac agcaacagca gcagcaccag cacttacttc agaaacagac ctcaatacag 1080 tctccatctt catatggtaa cagctcccca cctctgaaca aaatgaacag catgaacaag 1140 ctgccttctg tgagccagct tatcaaccct cagcagcgca acgccctcac tcctacaacc 1200 attcctgatg gcatgggagc caacattccc atgatgggca cccacatgcc aatggctgga 1260 gacatgaatg gactcagccc cacccaggca ctccctcccc cactctccat gccatccacc 1320 tcccactgca cacccccacc tccgtatccc acagattgca gcattgtcag tttcttagcg 1380 aggttgggct gttcatcatg tctggactat ttcacgaccc aggggctgac caccatctat 1440 cagattgagc attactccat ggatgatctg gcaagtctga aaatccctga gcaatttcga 1500 catgcgatct ggaagggcat cctggaccac cggcagctcc acgaattctc ctccccttct 1560 catctcctgc ggaccccaag cagtgcctct acagtcagtg tgggctccag tgagacccgg 1620 ggtgagcgtg ttattgatgc tgtgcgattc accctccgcc agaccatctc tttcccaccc 1680 cgagatgagt ggaatgactt caactttgac atggatgctc gccgcaataa gcaacagcgc 1740 atcaaagagg agggggagtg a 1761 <110> Seoul National University Industry Foundation <120> DNp63a Gene And Screening Methods of Anticancer Agent By Using It <130> PN050058 <140> PN050058 <141> 2005-05-25 <160> 3 <170> PatentIn version 3.2 <210> 1 <211> 107466 <212> DNA <213> Homo sapiens <400> 1 atgttgtacc tggaaaacaa tgcccagact caatttagtg aggtaaggat tttagatttt 60 agcactccat ttagagatgc tttttaattt ttatttttgt aaaaaaactt acgtatttgc 120 ggttctcggt cacccaatgt aatgttttgc aaattgtata taggaatctc cttttcttgg 180 ttaatgtttt ctgtggtggc tgtaagattt tttttttttt attaagtagg agatgaaaca 240 gtaggagaag atgaaaaaga aaatctgggt gacattatgt atttgaaaaa ataatattca 300 ggagtttata aaatcacttt ttagaaaaac agactcagag agcagatcac actctgctag 360 atacattgca atgaatcctc tgatgggtat tcatgtacca gtaagaaaaa tcagttgact 420 gtgtcttaac ttcttagcat agttctattt ccagacttca tcctaaaagc aaatgaagct 480 tttttcaaaa taatcaggtg agatttttta aagccatctt cgtttttaag tctgtcaatc 540 cagagaccca cctaaatcca gaaggggctg tgataacgtt tctgtcgtct ggagggtgac 600 ttgtactttc acgtgtgatg acaaataaag ttattttgga gggatgcatt gttaaatatt 660 tatacatgca tacatgtaaa tgtgtattat agcatacagg attttattta agaaactgat 720 tatttgcatt tctgatctct tctcagcaag tttgtcttag gtatttaaac ctgtgcaaag 780 ggataaaaaa aaaaatcctg aagagactgt aaggctttga ggaagtttcc taaggttgag 840 ggaggtctaa caacaatatt agtttacatt cctcagaatg gggcagctgt gttgacacta 900 atcagattgg gttgtggtgg ggagtgttgt ggagagagag agttcggtgt ttcagataaa 960 aatgcttgca ggtgagtgct tggaaaagtg gactagagta ctcaaattga gctccttaaa 1020 aatcaaaaca aaatgcatag tattccggtg cagaccgcaa gaggaagagt agagcagagg 1080 gctgcgaagc agggcctgtg ctatcgtatt gaccacgcta ttgtctagac tcctgaactg 1140 tgtaaataca acaggggaaa tatcgagtta tctaaagaag gaaaaggaag tgcctatttt 1200 tctttaaaac attcaagcag gcttgcttgt cctcagtaga gaaacttgag tttcttgttt 1260 tgcagttata ttgaaagtta gcttaaaatg ttaccaattt gtttttaaat aggattagct 1320 tttaagatct tcttgattct attggatcca attttgtcca gttttaatca ttcagaaaat 1380 gatctgtcca tcatgtcata cctgagtttg tttgtcttta ttcatgaact atttcacaca 1440 cagtatttat aagccgccta ggatcttgta agtcaaatgg gagaagcaaa agtctgttca 1500 ttgatatctc taagtgaagc acaaggttga tgtaaagtgg caagaaatga ttaattttag 1560 gttaaatata atgtcgtgaa agaaagcaat tgcattaatg ttgtgattag aggatatttg 1620 tagaaattat ttccttttat ggaggcaaaa gagtcatatt gtatgtgaga atatggcatg 1680 cttatgaaag aaaatagttt tatacacagg ttttagtttt tcacaactct aggtaaatat 1740 gtaatcaaga gctacaaaag gcatcccttg tctgttttct attggaatgc tgctaaggtc 1800 gacaaaaaat atctgtaaaa aacatggctg cacttcccta cctttctatg tctttttgca 1860 tgttgcctgc atgactttca tatccttcca ccagtgcatg tattaggtta taatttcatg 1920 gcttgacttc cattctatta cgtacgaaca actttctttc tgtacaggat tatgctttca 1980 tatctagtcc tctgttaaaa ttcagtgcta catctgagta tatgaaatgc ctggcaccac 2040 atggctctga gaaccatgaa tttaatataa aagttataat gtatagggat ttatgtttat 2100 tagtaactgt caatacagaa aaagcaatct actattatta cacaagaatt gttaaacatt 2160 gggtagatta aaaatgaaaa aggcataaaa ctccctgtaa gagtgaaaat tatttaaaaa 2220 ctataatcca ttctttgact tcaaataaat ttatagttta atttgctagc aatttctttg 2280 agttgataac tcaaaaacta tataagaaca ctgttccttc tctattcctt ttcccacaac 2340 ttttgaattc ttccccaacc cttagcagat ttggatttgg gggagctgct aattaacagg 2400 aaatggtccg gaagggagga gaacacaagc aggatataac aggcaaggct gaaggctcta 2460 cccttgggta cagcggagag gccgcaagca agctccactc cccagtgcca gactaggaaa 2520 gacagagcct ctgggaatgg tctcagactt ggagatagag agggtcaaaa taaaggaact 2580 tcttcacaga tcaagtttta acttcaactt tctggcaaaa caaaacaaaa caaaactggg 2640 ctgtgtgtgt ggtgtaagtg tgtatgtgtg tgagtgggga ggatctcaaa ctccttctta 2700 gaaagagata tttactaaaa ttcctcatcc ggggttttag atgatgaagg aaagacactt 2760 tggtaaatgg gttacagtat tttcgaacta aatgggaaat caaggttcat atatggaaac 2820 acctcatttt acaaatcagg gttaatgatt tttctttctg tagttgagag agctatatgt 2880 atacgatcgt gttcccttta ctcagccact ttctttttaa taccaaggag agatgggatg 2940 attcatagta gatgctccaa aacagtttcc atgaagaaca gttgtacaaa gccagttgaa 3000 tgcaagaaaa aaagtgtgga gacagcagtg taaactccct gtagtccagg tcattctcac 3060 ttaattgact tctttgtctg cttggtctag ggaaaaaaat ctgtcctgtc ctagtactat 3120 ttctactgac tcaaccattt aaaagatatg ggtgtgagtt ttctattgat agttaataaa 3180 tgtattaagc tgtcccatgt tgtacttctg agctagttag catcatagga aaaagcacag 3240 tgggtgagaa gcagaagctg catttttaat tagtgtcagc caggtcgtat tcctcactcc 3300 atgctgttgc catagattgc actacttgtt ttacagttgg ttgtcctcga gcccagaggg 3360 aactaggaga aagacatctt agatcacaga tcacagatca taccttcctt cactactact 3420 ggaaaaaaaa agattttgag acaataaatc acttatcctt tacctcgata aggaaaaccg 3480 tgtttggttt ggtttgcttt ttagaagagc agtgattctc aacagcatgt cacacgtaca 3540 gcagaaagca tcaatggatg tctacatttt ctagagcaac caaaaaaata ttggtttctt 3600 tttcattata cgtacatttt ctgaatgcaa agttgctaaa acattcctca atgactatgg 3660 acagaattta gattctgcgt tctgctataa agggagtata tatctaatgt catgagattt 3720 taaaaaggga tttggatcaa acagttgaga aatatgttac cacaaataca ccctggtttt 3780 ctttgatgtg catatgattg ctctgggtgg aatctgagct ggtagaatag aggggcacag 3840 gtaaaaatcc ttccttccta gtataacttt tctctcccct tgaatatttt taaatttcta 3900 attgttttat gtcaacaaat agaatgaata caggtaacaa aaagatactt ctgtgaaaaa 3960 caacttgatg atttccataa tttataagtt ttactatttt gaagataaaa aattgttaaa 4020 cccaagtggg cgctcaattt tctttagatg tatgttgagg aaaatgtcag ttgactaata 4080 tagcattatt gtccagtgcc aatttagtgg aacctacaaa tggtatccaa tagagtacta 4140 cattttgggt ctggaagagc atggattcaa gtgtcaaggt gaaacatttg attcaaaagt 4200 taagttttaa atcttattcc taatcttaag gacacaattt gtgggcccaa gaaaatagtg 4260 aaatgtggct tattaatggg ccaccactct aaacatttta taatttttac ttatactttt 4320 tgattaagtt ctatgttgac aatattcatg aaaagtagta ttgagaaaga gaaacaggtt 4380 agaagaagaa ctgactgact cttaaaaaaa tgtttactga gcatcaatta tatgtaaaat 4440 ggtatatagg atctaaaaat aattaagaaa taattcctac actaagaagt ttatagttct 4500 ttgggggaat gagctaagta tgcatgcaat tataatacag gagagatttt aagtgtgtga 4560 gcaagataat ataaagcatc aaagggaaag agagtccatg atgtaggaag atcaagaaag 4620 tctatatgca tatgtaagat gaagctgcac ttggaaggac agatggaaat ttccaagttc 4680 tagaaatata agaaggaatg aggattttag gtgaagaaat aagcatcagc aaagggaagg 4740 ggggtgagga gtgaatgctg gtacactcag aagcatcaaa tagttcaaat gcaattgaaa 4800 ttatgagacg atcaggaaat aaagttggaa atgcaagata gagtggctca gagatgacca 4860 taacactgag aggagagtac atttatcata gtgacaatga aaagccatgg aaggatttcg 4920 aacagaagaa tggtgtaatt gtgtaattgg agctctacta gagagcacag ggagaataaa 4980 tggctttgct tgagattgcc tagaagtatg aaaatgcatc tctctgcatt gcacattggc 5040 tgcctgtttt gcagaaatat ctatcagttc tcttggatct ttggaaggat acgcatggat 5100 tgtttctaaa gtctcataca acctgtgtat tttctgccca gtgctctttt taatagctat 5160 ggtccctgcc atagacaaat tgggaactac tggtcttggt ttgtctttat ttatgcctgc 5220 tattctagca taattactaa tagcacacct tttcactttc aaaactgtcc catttagaag 5280 ataaattata tagtcactct gtaaagaccc cattctttat ttcattctct tccacacact 5340 aacactccac cccaaaatga aaaagtagta taaatttggc tgtaagccag acacaatgat 5400 tttgaagtac cagccacaaa tcattttgat tatttccccc actaaaggaa acacttcctt 5460 ccaacccaac agttactgaa aacttataat agtcactgtt atatgcactg tgaggaaaga 5520 agaaattagt aattcacagc ttctagcctc cgtgaattca taatctgagg gagttatgag 5580 gggttcgtaa atgactccag tataaaacag aattggtaaa agatatccca agttttgaaa 5640 gagtgaaatc gagttcaaac tgtttatgat aaaggtaata ttttatatgg tttgagaact 5700 gaaattcaga tgtggcgtga ggggaggaaa gacattctat gtagagggga taaaatttat 5760 aaaaatacaa gggaggactg tgccagacaa cgtgaaggaa catagtatat tgatttaaaa 5820 agaaaatgtg ttggtttaaa cactgatatg tatttactat ttatgtcaaa atggaacgct 5880 tttgtagaaa tagcaacaaa agttaattgg aatattgatc tcactaagag cggaaaccta 5940 tatgtgtttt aaaagtgtga ccagtgttca gaattcgaga ttcaaaactt cacatactct 6000 agggatgatg agtgacatct tgcaggaagg aaaagaaaat tagcccgaat gattccttag 6060 gctgaaaagt tgaggattac cttttcccgt tccttagact tctacagagc cagatatggt 6120 gtcctatcat ttatagggac ttagtaatga cattttaaaa cttatcaaag ctaggaacaa 6180 aattcaaact gactctctgt gtttattatg agttaatttt atttattaaa tagtcgtctt 6240 agaaatagga ccagaagtct tttctctggt cactgctcta aatgcaaata gtaatcctga 6300 agctgaatat aagacattta ttcagaatga gaatcccagc tgggaaataa ataacagagc 6360 agagggaaat atgaatatcc catttaaaag ccaaccccac caaataaaaa atttaagata 6420 ttatctttgc cataaaattt ttaaatttga ctttgggaca aggatacatg tgtaagatgt 6480 aatatgtaaa gataaatatt gggagaagac atgtcttttc ccacatcaat atcctccctt 6540 tccacagcct ccttcatcac ttccatctca cccaagaaga ccacgtgggc aattgaagag 6600 ataataacag ggcaggggag ggtaggccat ggtgggagga aggagtgaac cagtgacttg 6660 atttaaagcc aaagggagtg gataagagaa ctgggcttca agataaataa ggagacatct 6720 aagctagtac tcatttcttt ctcttttttt taccaaccta atcctccact ttcaaaaagt 6780 agattttgaa agcatcaaat gttaacatat gattgtccta cagacattag gggaaacagt 6840 gaggttccac taaatacaac ctccttaaaa gaaataagta gttcaatgaa gtgtctgtaa 6900 aatcttttca aaagtcttac tttatacttc cccacagttg atttccttag ttggtctgag 6960 aatatagcac ctatactatt caaaaactat tcttttccat tttctgcaaa aaaaattata 7020 aatttcttat ttctaagttg attgattgca tgtttgatat ggactaactt tattctgatt 7080 ttgaagttgt tcaagcttct ttttcaaaga caaagtacaa atggatcatt gtatggattc 7140 gagctgagat ggcttcacca gataatgttc acctgtcaat ttaaaattca gtcactgggg 7200 ttaagataga gcacatgttg gttctaggtg agggaataac tggcaagaat aaaacatttt 7260 tggaatgtta gtgaatgtgt gtgtaacgta aattgatatt tcatgcaaaa cttgtaatct 7320 gaattgcatc ttgtctgtat ttcttaaatg gcaaaaagat ttccttataa aagctgaaag 7380 agggaatttt gagtcaagct gtggtgtgtt gccagaggcg gaaatttatg aaacactctt 7440 gtcagctatg ctggaaacac tacaaaagaa atagttctac tttcttattg gtgctaaagc 7500 cactaatagg tgcagtttag tataataccc ctatgagaat taccaccccc gaagtgagct 7560 tgccttggaa ggaactctgt acaggcattt tctttttcct tttaagcttg cgcaaaacac 7620 ccaaaggggc catttcccac ccagccagtg atctttctca agtttattct ttctcagatc 7680 acagagacaa tggggaatat gccctgttta ctcaaatcag tctggattag tgtcactcta 7740 ttgatggagt cagaattaaa aggaaaacca ttaccctctc aaagggcaac atcagatgtt 7800 tggggaatgg cgtgattact tttaaataga ccgtgtgaga ctctgtcacc agactgaggt 7860 tgaggactcc acaagacaca cttgaagaga aacagtaaca ctgggtgagg caggaagctc 7920 ttcataagcc ttaggcctgg gaaattattt caacagacaa tcccaaaatg cttgaaaggc 7980 tgaaaatcag aatggtgaga cttcagagaa gagggctttt ctgccttctt tctttgctcc 8040 aacacctcac ccccatatat ttatctccag gtcaaatcct ttccagtcat taagccctgc 8100 tggggagaaa cttaaccctg aaaaagctct cagattcccc cattcaggat aacacttcca 8160 tcctctgaac tcttttactc tgtttcttcc tcattgctct ctgtgtacac cagatccttc 8220 ctccctatcc tttgactgaa gaccctggga gggtagagga tgtgttatgc ttatctctgt 8280 atcccctaca gggccactca gtaatgttcc ctgaatgtga tgaggacatg catctgttgc 8340 tgttgcttga agggatatct tcacctagga atatatggtg tattgtatat acttaaaagg 8400 ctgtttgtaa ttgacttgtg cacaaaaata aataaagcga gccgacatat tatacaagcc 8460 tcttctatct atatgttctg caggtaaacc aaattgtgtc attttccttc acatcttgca 8520 ggtcatttgt ttttgctgtt tgtttgtttt aataagccca atattatttc cattatcttt 8580 taaatagcaa gaaagttttt gaaagacagg gcagatgatt tgtttggtat caagtaatta 8640 gtgtaaagta tgtgctgctt tcacataatt gattactcac aaggacagag aatgtgtttg 8700 attaaaaaaa agtcttagat ttttatcttg ctttgcaggc cctttttaaa agtgtttacc 8760 tgtgtctgca ctgttccctt gattcagttt atcccctgca gttctctctg tcctcaccag 8820 agatggggga agtttgatct gggtgaataa gcttgatgat ttgcaaacgc tctctccttt 8880 taattctcta tagtgttatc actaaaggat gtctgagaaa cctcaaagca atttttctct 8940 taaacgtggt attccaactt ttggttttgc tcatatcttt tataatagga caaatagaat 9000 aaaatgaata agacgagtgt cttttcaaaa gtaaggcatg tcttctgcat agctcaaaac 9060 ttgagtttta ttttgcagtt aaagtgacag ctgagaggaa cactccaatg ttatataggt 9120 caccatatct aattgcaaag taatcactaa aaactttaat tatctcaaat ataacttaaa 9180 aagtagcaat cagcaaagaa tttgacaaac aaaagcaaat tagaactcat gaaacagtgt 9240 tccccgcttg aatgcctata gtctaacaag attgagtagt acactccttg tttcaagcct 9300 cagttttcca gttgcaaata aaaactagtg tttcaacctt taagtgtttg ttatattgga 9360 gcataaattt atatcatttg caagaaagga tttataagtc tgataaacta taatctcagt 9420 tccttaaaca tacaatcaca aactgttaat tatggcttta ttctaaactg aattctggct 9480 aactgggcat aaaatcatgg aaattaggca gggagggacc aattttgtgg cctatctacc 9540 agaaactaaa tgtctttctc taagcttgtt tctgggtggt ttcttttcaa agcaacctgc 9600 atttggccat gtgctccatc agtaggaagt gaataattat atgaccacaa agatataggt 9660 tcttattgct gacctaggtg cattcgaaac aaaacctaga ccatcaggtt aaaaaacact 9720 gccttggcac aaaagtgtgt atgtgtttgt tttaaggaag tagaagctca ttaataaact 9780 tcccagctag gtgtgagcta ccaagtatta ctcattgtat tgtgagtgac aggactggct 9840 attctgctac tagttcccat aaaagctgaa gctaaaagca caattcccac ctaccaagac 9900 aaagctaaac aaaaagtaaa gatcatagag attatttagg gatgcactat aacatttgtc 9960 tgacagtagc atataaagaa atgaatcaaa tttggacaca gactcaggat aaaataaatg 10020 atcagttgta ttagaataaa agagatactt tctgcaagta attttcatgt tgaagtgttt 10080 tgcatttatt cttttaagaa ctgtctcctg agcatctatt atgtttcagc cattatccca 10140 ggtattgggg attcagtact aaacaggcca gatatattct ctcattaact tattgcctag 10200 cagagaagac caacattttt aaaagtttat acatatagtt aatttctatt atgattatat 10260 gatacaaatg gaaagtgcta tgaaaatgtg gaacaaaaga gaataatctg tctgaacagt 10320 caaagaagac ttctgggaga tgacatctga gctaaaggtt gaacaaggaa ttggaaaaca 10380 gctggcatgt gcaaaagact tgaagactga aggagttagc ctttaaaaaa atgaagaaag 10440 ttctatttgg ccagagcaga gtttcaaata gtgcctcaca ggccacgtta aagacctgag 10500 gcctttattc taggagaata gggagctgct caaggaattt aagcttgaga gtgacaagat 10560 cagatttgca atgcctttca agtggtagtt acaaggagtt gggtctctga ccctttgcaa 10620 ttatacccat tctaactaag aatggggaaa cttttatatc ctgtctttaa tgagtaaaaa 10680 aaaaaaaaag aaaaaaaaag caaataaaag aggtgcgctt ttcttgattg taactttcag 10740 ataaaaattc caggcagaaa tgtgagtgat tcctatttac atgcagtcgg aatgaaagct 10800 acttaggaaa gcgggttccg gagccagatt tactggttcg acatccaggc tcttctcact 10860 accttgggcg agttacttaa ccttgtggag cttcagtttc ctcatctata aaacatggat 10920 aaaacatgga tattaatgcc atgtgtctca tgagaaataa gtaaaaccat gcaaagcact 10980 tgaacactct aagacacata cttagaactc cgtaagagaa ttaataatag tagaagtaat 11040 tgctcatttt cttttataga ggggatggaa gatggatgat aagtagattt cagagtttta 11100 aaatttattt ttatttttat tttttgctcc tgatagtcac cattacttta ttgaaactga 11160 tatgtcttca gtttcatgtc atggtaacga aagcttattt tctgtgataa aatgttaatc 11220 acatttaatc acccgttgtt ttaagtcaca atttaggata tgaactagac aaatatacta 11280 ccaacattat ttaaaaaata tttttaaact cactttccaa accaaggatg cattactgct 11340 gggcttctaa aggcagtatg gtatgcttaa cataaagatg gcttaacatt cattgaagaa 11400 ttttattact atgtactttc ttcttttaat attaccatat ctgctatata gagctatgaa 11460 aacatattga ttgctataga ttgaaaatct cttcaaacat attttgattc acttggaata 11520 aactgaaatt ctgaatattt cccctaatac cagaattaaa aattattaaa tattaaaatt 11580 ctatcctgct ttctgcttag tttgatactt ctttgatata aaatgataat aattccttca 11640 gaattgggat gccttctgat tttcattttg ttgagttgtt atgattatta taggagtatg 11700 tactaaaata atataatttt aaaatttatt tttcttaatt gagttctaca cattttaatt 11760 tagctgcatt tggatcaagt tttaatttta atacctttcc cacttcctgt cttttcaaat 11820 gttgtgtcaa atgtttgttg acattgttgt ccacctgatc agacaacttt gtatttattt 11880 ctctcacctg ccgttggggc ttctagagct ctttctccta aattatggaa tcttggcact 11940 caaaggaatc ttgacacttt gtgtcagaac acaggacatc tagtgaactc tctgcttaca 12000 gtcttgatag ttttgggtgc gtttaaatac tttattctta tattttgttc tttgtatgag 12060 tatatattaa gtattcactt tttatataat tttagaaaac aaaatgagtg acatatttta 12120 tacctaataa aatctggttt tgagaaaaat gtgatgctac ataaattctt cggttggaaa 12180 gatggtgttt taacttgacg tttgaatacc aatatatttt cttaacctgg agtagaacac 12240 tgtaagtcaa ttgtgtttaa ttctagcata aaagaaacca tcattctctg aggtggggca 12300 ggtggcagaa gacgaaaaaa tgacaagtat gtctccctta ggcagtgctt gttgaaaagt 12360 cactatcctg ctgatatttg gggatggaaa tgtagtactc tctgctaaag cataattgaa 12420 tgaatgcttt taaagccagg gtcatcaagt aaagctgttt tctttaccca tgagggactg 12480 tagaatgttc ataaaagcac ctccgtgaag cctcaggtga aaggtggtta tcagctgagg 12540 aaactgtatg tgctgcctaa aatgttttag atttctaagt ttggtcaggg acatctgtat 12600 agagagagaa cagttacctt agaaaactgt tttgaatgtg gtcttatagc attgttttaa 12660 cgtagcttca cagatgagga tggccataag tcacagaatg ttagaactgg agatccctct 12720 cattgaatcc tcaaattcag tctcctcaat tttacacaga ctttggatta tggtaaacta 12780 aggtccacaa gttgttcagc taccttgccc agaggtacac agcacactag tggcagtgtt 12840 gggacttaga ctccatgtaa agaagtttaa gttcagaatt cttttgcatc actaggatcc 12900 atacaggagt gtaaggagta ctgaagcgtg ttcaatcccc tagcctcatc caccagtcac 12960 tcatggatta taaatacaat ttcttccaag tgaaatttgg gaatactgtt gtatcttgta 13020 acaaaggtct ggttgaatcg agataagtta tgattatata tcccaacagt aatctcttct 13080 acccctgatt tggtccctat cccatttttt taataacctc ttactatata ttgttgacta 13140 ttgttgctat agtgtcataa atttactatt atagatagta atatctgaaa aaggggacat 13200 tttaaaaaat tctcttggcc aggtgtggtg tctcacacct ttaatcccaa cactttggga 13260 ggctgaggca ggtggatcac ctgaggtcgg gagtttgaga ccagcccgac caacatggag 13320 aaaccacatc tctactaaaa atacaaaatc agccgggcat ggtggcacct gcctgtaatc 13380 ctagctactc aggaggctga gggaggagaa tctcttgaac ctgggaggca gaggttgtgg 13440 tgacccaaga tcgtgccatt gcactccagc ctgggcaaca agagtgaaac tccatctcaa 13500 agaaaaaaaa ttatctttta cagataaatt ggtggagaga gattttcaaa aacacaaatt 13560 ataggtaaat acctatttct attgcattgg tcaaatagct tcattggaat ctctttttga 13620 tgttaaatac ttttatagga aaataattac gtcatcaact ttaagtaaat ataaatccaa 13680 ttatttaata ttgagttata gcaatatata ttgacacagt tttgtttctt catggtgaaa 13740 acagtttgag attcagctcc tgggtatctt tatacctacc atgcaagctg tatgtttcag 13800 aatgccctca gggtgttcta tgattgcagg gaatatgtcg agtccatgtg accaaggcgt 13860 acttcatcct ttctgtgatc agatcagcta gtttgtgagg aacctgaata tatcacaact 13920 acaaataaat tttccagggt ccaaacagtg attcttctat ttcaaagtta ttttatagaa 13980 aatgaagcat ctgtttggaa tcacaggaaa ttattttact ttataagttt cacagtagat 14040 atcacagaag ttgtgttcat ttttgccttt atgttttgtg gaaagaatac tgcctctttt 14100 ttcagacatg ctgagataga tatataatgt ttccattcac tcattatttg ggtgtctgca 14160 gggtatgtta aggttattcc aaaatcaaga tgccttgtgt ttagaaaggg agaacctgct 14220 tcctatttca tttcagatac gccaataact tttgttacct aagaaataca tgcatatggg 14280 acatgggggc tctatggagt tcttccaaag gccgttttta tggctgatct gaaagtatag 14340 tgttctaatc tctgagactg actctttgac ttgtcattgt cagtaagcat tgcattaaca 14400 tcccagcata ttacacattt ctctcctctg ttatggaatt attggctgta aataaggcaa 14460 gaggtactgc tccctttacc ccgccagatt tgctgtgata gaaaataagg gatagatatt 14520 attcacttga cctgggacag cttcatgggc ataaaaactg caattggtca cacagggccc 14580 tatcttagaa aagcaccatt ctttgtttaa tgctttgcta tcatcatttt gaaattctta 14640 atctatgaac aagaggttct gcattttcat cttgcactga gcactacaaa ttgtacaaat 14700 tgttttgctg gacctgtctg ggtgacactt gttcttcttg actataatgg ccagcccttg 14760 gcttccaatt gtaccctgtt aacacacgcg atctttcttt aaatcaaagg aataagtgaa 14820 taagaatatt ttctttaaac tagatatttt aaaaattaac ttctgaagaa tgaatttatt 14880 gatttttaat aaactaagaa aatatgtaaa tggatttcca gtcattcagt tctgactttg 14940 gtgggtttgt tgttgtttct gttcatttta agctaacatt caaagttagt agtgtcagtt 15000 ttacgctttc caggaaaaga caacggagta tactacttgg cttatatttc tgtaaagtat 15060 cacttgagaa gcgtttcaac tgaaatgtgt tttcccactt tgattgtgtg tagtaggctg 15120 atttctcatc aatcctaaga aatatacctt tatgttatat taattgagga tttagcattg 15180 gtaacaaatc ttgtttttct tacgtacaaa atctcccttg ggactggata taatttaaaa 15240 ctatgacgcc taaaagtaga tccatcagta cccacattgc tattcatgac ttttgaaata 15300 cagtttctgc ttctttgttg cttctcaatg gttcagtctt tctatcattc caaaggactc 15360 ttgtgactcc tcagtaaatg gaattttccc tttcttttcc ttaatatcca taaaatcagt 15420 ttactcaaga aattatatag cagtatacag cctaaaccct ttctcaaaat tgtcactagc 15480 ttttcttatt cattaaaaca ttttcatctc attacaaatg atttcttcct ttaaaatttc 15540 ccagaaagta tggcctctgt attttctgct gctcagttta aacacatcat caaagacaga 15600 taattattaa tgtcatatga gcataacagg agatttataa atcagaaatg tattttctgg 15660 gaaccaactt tcaagttagt caggtaagtt ttattaactt cactggtgaa gtcctaggat 15720 aaagcagtgc ctagatcagg cttgtttacc cttggcctta tatggcacca aacactgttt 15780 caggacagtg gaagaacagc ctgggaggcc ttcggccttg gccagccttg ccgaggcccg 15840 ctcaccagga gaaataggaa ggaaggccag tgagtgtgca aaggagcatg gcttattttg 15900 aggtcctgaa ggccagtgag tgtgcaaagg agcatggctt attttgaggt cctgctgatt 15960 gcaggccaac aaaacaatgg caggatttga aggaagaaag tattgcaaca gagtcaccgt 16020 atactttgaa ctgcaaaggg agactgagga aatgttgcct caaggccaaa aaccctggct 16080 caaaacacag gttcctcagg tgactcagag gcagaccaag ttcaccaagt caaggacatt 16140 ttcctgctac ccccctgggg agaggggcct tcaccaaacc accctggaca tggatctcct 16 200 gctgttcaga acccacccaa taaacaacag aagcaaacac tttttttttt tttttttttt 16260 tttttttgcc ccttacacgg aattgtccct ttttgtaagt ccttgttgaa ttgaagagtg 16320 tttgctcact ggcttttaaa gtgtggtccc aaaacttttt tcttcgttta tattgggtta 16380 aaaaaaaaat caaggggccc atgcgtcttt gttctcatcc aagcccacaa ttagttagct 16440 ggggttcctt ctgtgtagct agaagcagga gggaaggggg tggcccagca ggcattttac 16500 tgcctgcgag aaagtgctgt gagtttcttt gtcctttttg tcagggacgg ctgcctccct 16560 aattgtactg ctgtagggag gcacgtgcct ttgggagcat tatctgattc ctacaggacg 16620 ttcaagagtg ctttgtatac tgacccttaa cttgaacaca aagaatatct tttcaatccc 16680 cttccgaggc tgttgcctca ggcttggata cctaagagct ttagttcagc cggggtatgg 16740 accatttata tgggctcagg ttttattttt ttgtccccta gttgtcttac ctgcagtttg 16800 gccacacctg ccgggagaga aagctgaaga tggtgggtaa gtggtggata gcagctatag 16860 aagtcagaag ggagagaaag cgagacaaac agctgctctt gtcagcatgg ggataagtgt 16920 aaagagatta atagttattt gaagagcaaa tggggacatg gcattcggca gtggaatgcg 16980 aatgcatgaa tgtaatggaa tgagcatgtg actattaaca tttagacaaa tgcttcctgg 17040 actgaatgga atggcaaagc ccacttctcc tccccctgtg gaaaaaaaaa agttcaataa 17100 aataattaaa agtttgaaat ttttaaaaag ataagcctag ctcctatttc tttgtaagtt 17160 tgttcttctc tatagtttta cttaatctgg gactctcagt tacatttcaa ctgaagagct 17220 aggcctattt cctttataaa atatgtacga ataggactgc cttaatcttg cttttgattt 17280 ttttttctca ttcattaggt tgatgaaaca agatttctat gtgtcggaag gttttacaaa 17340 ggaaaagcaa ctgtaccata agctggttgc ccctttgttc attttggctc aggtttagaa 17400 atgatgatag gctgatttgc ctactcaggc tgacagtttt gatggcatgg acagagccct 17460 gaagtcagaa ccagaagatt cagcaccgaa agccccagtc attgtgttag cggatgctag 17520 ggcaaatgct ctacctctcc gatagtaata tagtcaagtt ttttgtagag taaatgaggc 17580 aaaattaatt tattctttca taaatatgtt cttgagtact tttactctgt gcttgggccc 17640 attcacatag aagacataaa aacgtttggc agaaggaaat acatgagcta atgtattttt 17700 gaattatatt gaccatagaa ttttcttcat aagtagttgg tatttctctt acaaatgttc 17760 tactctagaa aagaataaat ttctattaag aaaatgaaag aacaaataaa aaagaattag 17820 accagtttgg atgatttact agcatgttac tttttaaaat acatagttgg gtgtccctaa 17880 ccccgctacc catgatcctc cagtctttgt gaaaccagtc cttagggggc tgggtggtac 17940 actcttggta ctctgggaca gaatgcagaa ttgcaagatt aagagaaaat tcgaaggtca 18000 tttgattttg ccccctatgc aacaatttaa cacttaaatc ccctctggaa catacctatc 18060 aagtggtctt tctcattttg tgtaacacgc cccaaccccc accaacaacc tcaaaatgga 18120 atagcaggca gtatttattt aaagacttcc taagcagcta ctgagcactg ggaacgtttt 18180 gcctagtttg tgaataagca tatactctac tttcaaatgc tctgtaggaa gtcagtctcc 18240 agaggtggca catagagctg agtgatctgg aaaagccgtt acaaacacac acatgctcag 18300 acttctcttg ttttctctgt ttaccaaaaa tcaacggttt tactttgaat gtgaagtgct 18360 tccgacgtga ggtccatctc tgtagaatgc attcacccat ggatgccttt ttttggagca 18420 atgatccgtg gcttcagcgg ctaatattgg ggtttctggg tgtccttgca gccacagtac 18480 acgaacctgg ggctcctgaa cagcatggac cagcagattc agaacggctc ctcgtccacc 18540 agtccctata acacagacca cgcgcagaac agcgtcacgg cgccctcgcc ctacgcacag 18600 cccagctcca ccttcgatgc tctctctcca tcacccgcca tcccctccaa caccgactac 18660 ccaggcccgc acagtttcga cgtgtccttc cagcagtcga gcaccgccaa gtcggccacc 18720 tggacggtaa gagcagcggg cacgcacata cctgaccccc caagtccaag gatgggcttc 18780 accacgtccc agggatttct cccccttccc agtttagcga ttccatgttc atggtggaaa 18840 atttgtcttt gaatatttaa tactgaacca gagagagaga aagtgccagt tagtgggaaa 18900 agtcccaatt taggaaccaa acgtctgcgt tctagccagc tcctggcaac ttcagtcagt 18960 gtgttcctgc ctgcttcaca ctgttgtatg tgaaagttca tggcaaggta aagagcgctg 19020 tgccaacaag aagtatcata atcatgggat atgtgtttac agtctccaga acgtgaacgt 19080 gtttaccagt ctcattcttg taaagaagta agtgtcacat taagttgtga ttttaaaaac 19140 tgagtaaaat aataaatata gtgttataaa aattaagaaa ataaaatccc atttatgaag 19200 gaaggatgaa tatgtttata catgtaggta tcaataaatt ataatttatc agtaaattgt 19260 ataatgtctt ataaattact atttataatt tatcagtgaa ttataattta ttgatatgta 19320 tatatttatt taatttggaa acattctttt cgaaaagaaa gcctttaaat agacatatca 19380 gagccctgaa ttagtccaaa gaaattgtta aagaaaaatc tttctgcata taagttttct 19440 aaggaagcat ggaattttct tttcataaat taggaagata caagaattag tccaaagaaa 19500 ttgttttaaa aaatctttct gtatataact tttctaagga agcatggaat tttctttttc 19560 ataactagat ccaagaatat tttattttga agtgtatttt gaaatgtatt ataacaagaa 19620 taaagctcaa gtataaaaga ggacacctac aaagttggtt ttaactggtt gatcaaagaa 19680 tgttcaagac caaagtggta tgtttgtcaa acaacttaat caagaccaaa gtggtatgtt 19740 tgtcaaacaa cttaatgttt acatggatta tagaaatgct tccaaatatc atcatcttaa 19800 taaaaagtag ctttagaatt gttttgacag ttttttccct ctttgacaaa tggatttctt 19860 tggaaagcat ttctatgttt atgttatata tagtatctag ttcattccag cctttagttt 19920 gtatagttta taaaatgatc ggcatgccta agacctatta cactctaaca tcatttcaca 19980 tccatttcct ctttttcacc tcatttcttt gtgaagtacc caggacaagt tttataactt 20040 ccactgtgct agtgaggaaa gctgaagaag ttggaggtta agttaagagg catgcctaaa 20100 cttacagaaa cttgtgtgta gctgggcctg tttttcattt ctgcttccct ctcactggat 2016 0 tgtatccttt ctttcaacca ttttatatca ggatctccca aaattgtcta aaaattaatg 20220 ttattttagt tctttcctct tgtggtttga gaagtaattc tccggtggct catatttcaa 20280 ctgtagagca tgaacatcag cttaaaactt gatctctcct ccacgtgtta cttatcaatg 20340 gagtcataat ccttagtttc ctttactttt ataattctgg aggcgatgga tactgcaggt 20400 gagtaaactt agagtttata ggcttcaaat agttggttga ttgatctaag tagtatcttg 20460 ctaaagagcc actagaataa ccattttata aatggagcac tgatatctct taggtcacca 20520 accggacatt tacagtcacc agtcttcaaa gctaacagtt actaattcag tttactccgc 20580 caggtctcca ttatattagg agtcagcatg tctgatgaga tgatgggcat attagggctg 20640 ctaaatgaat aatcgctttt tttccctgta aaatttttag aaaaccatgg ggatgaatct 20700 tgatgtaagt tcaacatcaa attagttatc cttccctgtc ccttcctcac tacctcctca 20760 tatagaaatc ttaaaagccg ggcgtggtgg ctcacaccta taatcccagc actttgggag 20820 gctgaggcag gcagatcacg aggtcaggag ttcaagacca gcctggccaa catagtgaaa 20880 ccctgtctgt actaaaaata caaaaattag ccagacgtgg tggtgggtgc ctgtagtctc 20940 agctactggg gagactgaga aaggagaatc acttgaacct gggagacaga ggttgtggcg 21000 agctgagatc gcaccactac atgtgatctg cctgcacaat agaacaagag tccgtctcca 21060 Aaaaaaaaaaa aaaaattaaa gttattttca ggtttagcat aatcctaaac catcactcaa 21120 agcccctctc tcagagaagt caattgtctt actcaaaaag ttggagatct ctaccaaaat 21180 gttaggttta aaagaaaaga aaatattctg gtacactggt aaaatttcct tacatgtgac 21240 agcagtaata tcagtgccct gacaaaaggg atacactgtg gtgatgagaa aaaggcactg 21300 actgagagac agaaaacctg gattatggtc ttgatcattt atgcaaactt agccaagtca 21360 cttgatcttt ctaaaattca gtctgtgcct cagatgagaa agaggatgag aatggagaaa 21420 cctactctgt tttcttaagg tgagatgata gtattaataa ttaacgtaga aagtttttag 21480 aagggctttg gttcgcatcg atatattgtc tgccattcat gagtgtcctt ggttaagtga 21540 ttttgcttct cttggatttt tgttcacttt tctgcattct acctataaat tttacaatca 21600 ggtttctact cacatatcac atggtaatta tatttttatt aaatttcttt cttgttcaca 21660 accaggctta tttcaggccc agttcatttc ttctaaatta gggcacttga acccttatct 21720 gagcagctac tgagatcacc taaaaagatg taagttcttc gtcatggata cctgcatctt 21780 agcttctaat tctttgagcc aaattatata tcctcatgtt tatacacaga cttcccattt 21840 taaaaagtat tttttcatat atttatctta gttgagcctc ataaccaagt ttgtaatccc 21900 cagttttata gatgaggaaa cttgaagatg taaaggtcac atggctaata accagccaag 21960 gatggggaag aatccaggcc tccctcaccc taattcaagt ctctccacca tcctagttag 22020 actgtttctc ctctggtttg agaccaggga ggggcataca ggagcaggca gtgcctgtgt 22080 agtttggagc ttgcctctta tgtcccagag tccaactggt aaagaaattt tttgtgcctt 22140 attatacaac acctatttct taggcatttg tgcattttag agcaattttt caaaataaaa 22200 tgctgcattt tagaactgcc cacaaactga aagaaacaga agctgctgtc attaggggga 22260 gatcatgctt atcgcatagt cttctggtaa ttctttaata aaaatatttt tagtaccatt 22320 ttatcacttg caatcctttt atgtcaagtt ttctttttta acttttctgg ttttaccctc 22380 aggattactg tcaaaatata gctaatatat ttaaagtata tgtgcatttt tcctttgcgt 22440 ttctgtgttt taaataacaa atgtgattat gtttccagtt ctacaaaaat atggtattta 22500 ttttaaactt ctttcaatga aatgaagtaa aataagacaa catttttcat cttctctgtt 22560 tcacacacac atacatacac gacaaaccaa cgtttacttt agtttcagat tttcttattt 22620 ccacaattta attgatacta gttacagagg cctatcattt aatataatgt agtgctggtc 22680 tagcattgta gttgggaatc gttaatcata ggacagttga aagaatggta gtgtggagat 22740 ggcaagaaac ttaaattcag atttcaactc ggaaacttac taacagcata tggggctttc 22800 accaaaaatt caatctctct aaacctcact tttctcacct acaaatggga acaaatggga 22860 acattaatac tttccttatc atgaggatta cttcatgtaa acatacctat tagcacctag 22920 ctactcatat gctcccaagt gtttattggg tctgaatttg aatttcttcg gttcgtgagt 22980 tcattgtagt tttgttgagg cttcgacaaa actttagtac ctttagttgt actaaaggta 23040 ctcatttgag agaatgaaaa ataaaatttc aactaatgtt ttttcttaaa gcttttgggc 23100 tattaacatg catactttat agagggactg tgatactatc cactatccaa atatatgaat 23160 agatggtata gggtgataac agcctctcct gcatgcagac ttctgcaggc tggctctgct 23220 gctttccgaa gcctgcccaa gcagatgtag gctctccttg ccagtgcaag gagaggccct 23280 ttccagattt aagaacctgt tgatttttga cattcgttcc tcatttttaa tctgatgctt 23340 catgatggga atgccttttt gtattctttg tgttaaggaa taacagtggg ccttacttat 23400 ggcagactca agatattaat gtataatgac aaactactgg aagcaacctg atcagtcacc 23460 cgtgaaaaac tagatggcat gttataagca ataaccatac ggccattaga aagaattctc 23520 tgtactgata aggaaagctt tgggagttgc tggtgaggga aaaagaaagc tttctgtggc 23580 acctgcttga gaattgagag tcctggtaag gaaccccact tgtaggggcg gtgtttcttt 23640 gtgctcccct ctagtgatga ggcttcttgg tgaacatagt tcagtctgtc ttgattattg 23700 gcctcacaca cctttgccag ttggagagct atttttcacc gctcatgaca cgagagtact 23760 ctctgtgtgc atacgccatg aaaatcctca ggttgttttt ttttttgcat tgttttgttt 23820 tttaaattgt gttcagactg aagtaaggac cctacccttg ggacatagga tcactttttg 23880 ctgttgtatc tttctcctgt cattgacctc aaggtcttgt atggcagact ccctgatcta 23940 gtgcccagca caatgtccag cacacagtaa acctttaata aatgggaagg aacttttttt 24000 ctctcataat taaaggaaac aattgtagtt cccagcagga gccctcaatt ctgactctga 24060 ttgttaactg cccgtgaatt tgttccctgt agccttcacc catgatttat agagagtgtt 24120 cttcctttgc ctttcttaac catgccagct tcgtgtcatg ttcagagctg tggagaattt 24180 gacttgagca agtggagaga ttagggaggt ggcgtttgaa aggggaacag ccagttcccg 24240 ggagagttcc attgatccca gcatatgggt cttggtctcg caagctcact ccctttggct 24300 ccgcaggcag gctgagatgc gcgcctgcgg cccaccctcc ctgtcatcag gttacctgta 24360 atgtaagact tttagaaaaa ggctgccagc tctgcagaaa tctaatgcaa cccagccaat 24420 tgcgtggccc tctggaattt agagactctt aagaatagcc catcaaagga caagatgtac 24480 agacaaactc ttcgatggta aataggattt atcagttttc tttcacagtg gaagcacttc 24540 ccccattaaa gtctgagtct catctggggc ttgatctaat cttacaattc agtggctgtt 24600 agattttatt ggtgaggggc agaagtcagt agctcgtgcc actggtacat gtgttcgtgt 24660 ttatcataac aagataattt ttacttcttg ccatagctgt ttcataaatt atgtgagatg 24720 tgtatcaggt gcctttttgt gccactccca tgatgaagaa aataatagca ttgagcatat 24780 taatctgtta tctaaactat ttcttagttc acagagtatt gaggaagaat gtactaaata 24840 aagtgcttag agatttttgg tgatggttca agtaacttac ctctaggttt tggatttaaa 24900 atgaatattc attgtaaggc atgcttccga agagttgttc cctcatccag agcagaataa 24960 ctgaatcagc gttcttgcct gagttttaga ttgactctag gttaacgtat tcgtgatgag 25020 ccagtttaat ctaatctaag gcttatcagc ctcccatact attttgagtg atttgttcac 25080 tgcaccgtgg agtgtctatt taacattaaa ctgatcttga tttattgcat gtgaacatta 25140 taaaaactat tgattttaaa aatgaataat ttaaataaag cttatatttc ttttcctact 25200 acaaagagta acagcaaaaa tcctctgctt ttcccttttc ttctttctcc ctattcttct 25260 cctcttcccg catttcttct cccccttctt tctactccct ccttctcttt tttccttcat 25320 ttatgttatt attgttagtt aatttggttt tgtaggtatc atcagctaca tggtatcttt 25380 ctttattttt ttttactata gcttcactct tctccataaa ttaatatgga gaacatgata 25440 tatatcaatc accgtggaaa tttttatcag gattaaatta tcacaacctt ttcatgtaac 25500 aaatcacttt ggtgaataat aatgggctgc tttagaggta gcaaacccaa atgtcattgg 25560 agtcagggag gtagcataaa tgagccgaat gataagtaca gaaactgtgg caaaagagct 25620 tatatactgt atctacaagg acatctgctt tacaatccca gactgttgtc acaggggaaa 25680 gtagacctag tattaaaata tttaaaatat taaattaatt atcacaatat taactcttaa 25740 atattaattt ttaaaagagt aactagaaac ctgggtttgc atgtaatatc ttcatatctt 25800 aaaatgatga tactaattca aaaaaaagtt gtaaaacact acaggccaaa caaaacagta 25860 cacaggctgc atgccatcct gtgcaaggtg ttaatggtaa caaggggaga ttactaaatg 25920 tttaaataaa ttaattggaa gttagttatt aaaataacta aaataactgg aatcagcatc 25980 taagagaaag gttactagtg ggtatatttt attcacaagt aataattctt tattccttta 26040 caaagtcata tagattaatc tcttgctgca tttaactaag caatacatta tcagaacata 26100 tttttctcaa cttgttttct tacagcaaat gacctttctg cttctcattt ttatatcatt 26160 ttatatttta aaaatctaat ggcatgcagg attggatact tggaagttta ttgtttgttt 26220 gttcctgtgc ttatcattag agaattatgg aactctgtaa cttaactcct taaaattggc 26280 caaagttgca ctcagaaaag agctttgaga tttaaagggc ttctaatcaa ttttctcagc 26340 ttactaacag atagcttact tttaattggc acatagtgtg ccagaacaaa aatcatctga 26400 taattgaagt ataaagagaa aataatgtca taagaacttt taatgactct ggaaaactat 26460 atcattaagc tcaaaagaga tcccttaaaa tgaatgcaaa cttaaaatcg gccctgagtg 26520 atgtgtacca tttattgtgg gattgtcgct cttggtacat ttccatacat gagctttgca 26580 cattctcctg ttcgcattcc ccaaattagg ttatttccat aacgtgacca agtctatgca 26640 attgttccta cccgctttgg taaagggccg atgtatgttt ctcatgaaaa gtcctcagca 26700 gttacagctg tcatatcgcg agtaaaacca tataactata tataaaaacc ccctggtttt 26760 atattagcag caattggtat gtctagtcag gtcactgtga ctgaaaggag acttgagata 26820 atgtagcttt ccaacaactt ccaattcttc aaaattaaag aagagtttat tgtagaatag 26880 aaagatagaa agataattct tcagttcttt gaagccctgc agacattttg tagatatgga 26940 atggttttta gaatgatgga tcctgtaatg aggcacacag aggcgtaaag gtaatgatct 27000 tagtagattt ctctcttgtg gtttttagta atgatcatga ccttatcatt aagcccccca 27060 cgtgaaattt aaaagaaaat ttgatagtag tcagagaccc tagatctaat ttattgtgag 27120 gtaaattagg gagggattct gactttacag atagaatgag acttctcatt ttagtctgaa 27180 tttaataatg aagattcatg tgggggaaaa aaaaaaccct acaacttgcc accttgttat 27240 tgtatcagaa aggcctgaaa acagagcagg gaccttaatt gctaattgtg ttagtaccaa 27300 cctttcaagt tcattgatta aataggagtt ccttcttgga ttaatgccta agtttttatt 27360 tttgttttgc ttcatgtgct gttcagccag tatcatctgc attgaatctt ataaaaacta 27420 taatgaataa gttgaggaga ctatttctaa agacttttcc tttgagtggt ttccaagttg 27480 tattaaataa gaagactaat gattacttaa gggttctcat ttgaatttga gaagacatct 27540 gacaggctcc tgaggagtgt gactcattaa gtagaatacg ggactcagaa ggacaacttt 27600 ggggtactaa caagctatat gaactggggc aggtcttttg tctctgtctg tatgttaaat 27660 gagtattata atttttactt ggcaagattg ctgtgaggct taattaaagt ttataaagtg 27720 ctttgggagc ctgagagatg aagctctaaa aacataatat gttattatct catcctggat 27780 ttttgttttt agatttactt gcttgaatct gtatcataac gatgcttaca attcaggcag 27840 ttttctgagg ttttttattt ctacaaagac atgaaataaa ataacataaa tatataagtc 27900 cctagacatt catatgggat gaaaaaatta cacataattt ttttctgatg taaaagagtt 27960 tcttcttaaa aaatgtttaa ttgaatctta tatctgttaa ccagctttat ttttttaaaa 28020 gcatttcagt gttttattcg taacattttt gcagaaccag taaaaagttt taaaatgcag 28080 tcatctttac tgggtcatga gaagaaaaat ttactccatt taaaaaatgt aaatacttat 28140 ttaaatgtaa ataaatatgc gcatttagat atatataaat ataaatatat tactccaatt 28200 gaataacaat ggaattaatt tacagtaatt agaatttgat aatttgggct tgaaagatat 28260 tcctttcttc tatctttctg ccttactttt ttcttctact gtgtgttcat ttgagatttt 28320 catatttata aaatataaaa atgtatatag agccctggag ttaatataaa ttgccttgaa 28380 aattcttttt attcctactt tgtattcttg aaagaaaaat catgttttcc cataagaaca 28440 gtgtcataat tatggataaa atttctgacc aagctattgt catcaagtaa gtaatagata 28500 tgtttaactc tatgtcataa aagcaaagct attaccacca taagccagta taattattgg 28560 aaataacaaa atgattctca ttgtcatata aactttgctt aaatatttta tatgccttga 28620 catatatgta ttaagtttac ttataaaatg ttatttttat aaacttatct agaactgact 28680 gctattataa taaatacttt taacattttg acatgccata attttgatcc atttcatggg 28740 gaataatttg agaagcctat gtttctcaaa attttcgtag gaaaattaga atggatactt 28800 gtataatata ttcctgttac taggaatgat gcttaaaaaa attctatagt gtaggtcagt 28860 cttcatttta agcaattgaa tccattttta atgatattac ttaagaattt tgcttgtaag 28920 aaaaaaaact gtatctgatt gaatttgaaa atgtagtttt ggagtgtatt tactcttcct 28980 gcctgatacc ccactcccca aaacagagta gtcttgagga aataaaaggt cctcaaaggc 29040 agctagatat gagaagagtt tgaattgcta atggggaaac ttctagacct ttgccttgat 29100 gttagaaaag gaatttgaga acatgattta tgtgttagac ccagagtttg tctttaaaca 29160 caattcaagt ttatcacctt tcttataacc tttctataca aaaccatgga tttagtgaat 29220 aaagcatttg gaagacggtg gatagttgat agataaagca gattgaccaa catgtaaaaa 29280 tagaaagtgt tttcatagta ggaatttgga ataacttttt ctatattccc atagttagaa 29340 tggatgccta gaaaatgtat ccttattgtg atgattaaaa atctcttttt gaactaagac 29400 acgtaagata gtaacctctt tctgctttgc ttattctccc acccaggctg tgttgaagtt 29460 atataagtat aagcaaatgt gcactttttt tttaaatttt attattatta tactttaagt 29520 tctagggtac atgtgcacaa tgtgcaggtt tgttacatat gtatacgtgt gccatgttgg 29580 tgtgctgcac ccattaactt gtcatttagc attaggtata tctcctaatg ctatccctcc 29640 ccccttccct caccccacaa cagtccccag tgtgtgatgt tccccttcct gtgtccaggt 29700 gttctcattg ttcaattcct acctatgagt gagaacatgc ggtgtttaca ctgttttata 29760 aaatgctttt gtctaatttt gttaccttta agtttagcta cttggcaaat aaacattttt 29820 aatactgctt aagtcaagtc ttttacaaat agaattgtca acatccaaga gttaccaaaa 29880 gatacttcat tctttagatt tttattgttc tttcacagta ctcactggta atggattata 29940 ttttaccttt tttttttttt tttttttttg agacagtctc tcactctgtc actcaggctg 30000 gagtgcagtg gtgccacctg agctcactgc aacctccccc tcccaggttc aagcaactct 30060 ctgcctcagc ctcctgaaca gctgggatta caggcgcgtg actccatgcc cagctaattt 30120 ttgtattttt agtagagatg gagtttcacc atcttggcca ggctggtctt gaactcctga 30180 ccttgtgatc cacccgcctc ggcctcccaa agtgctggga ttacaggcat gagccaccac 30240 gcccagccct attttacttt tatctattgt caatgactac attgaatact tttgtatgca 30300 aatgtaacaa aggcatattt tgcagttatt tatactttat gtctgagaat tatcacataa 30360 tttagcaaac attaactcat ctgtttacct tttgctgtaa aagctagagc aagtgatgta 30420 gatggggaca agaaaatgac tcactcagcc tcagaaccac aaggaactat agacttcttg 30 480 cagtctggtt ttctcttcaa aaagcaatta aatatacgac catttgtata agtttccaca 30540 atgcattcat atttcagaac tgatttctta cctagcacgg catggatttc agttataatg 30600 tttctccttg cacaagcatg gtagacatgg ggttagtagg tataagaatg cctctgggaa 30660 caatctttta aggttttata gactcttttc tctcaccact cccccaacct aagtgtaatt 30720 gtcatcttag acactttgag tttaggggtg gagataggga gagcatcatc agaagggaca 30780 aaaggagaaa ggggaagtga aatggtttgt tggatactag tgagtggagc cttttacaga 30840 agtacaatgc acgcatttta catttgttag ttagatgttt tctaagatgg ttttgtagct 30900 ctgatggtat atttttatgg atataaactt ctaatatgag gaagagaccc aaaccaattc 30960 aaatagcatg ttaaaattca atctatctac aatcttcacg tccttgatta ttacattctg 31020 taatctcatg ggtatttttg cttccaaata taaggacata cctattattt ccttcagttt 31080 tctttttagg agagttgact gaactatttc aggaaagaag atgtcttact ttcctttgcc 31140 tagtaagcct tgctgctttt tgaacacagt gcattttctt caaaatatac ccactacttt 31200 aggtggtctt aatgaatgaa taatatgtaa ttgtgtatac ttttctaaaa ttctttgaaa 31260 cttccaggaa ggaaggtctc attaaatatc tatttgaatt ttagtgaaaa gaacaaaaaa 31320 aagcaataac aaattaagac ctttgattca tgtgtactag cagtggtttt attttggtag 31380 ctagtgctgt gatgtaattg aagcagtatt ttcatataga agcatttttt acttttatgt 31440 tctttctact tgttagaagt attcttttat tatggttact tttgaatgta tgtttccctt 31500 gcactaactc agaatacagc ctcacttcac agcgcttaga tttgattcct gcattcatac 31560 tgtttgcatt tgagggtcct ggtgactgca gtaatctcca cctcctccag agccagagag 31620 aaagaaatgg ccacagctac tttgtcatct tttgtcactg gtctcaatag agggtcaagc 31680 gtgcttacca catggaggat gcttcagaac aacaagggaa agaattagag tgttgcctgg 31740 gtactgccca cgctgctata tgaacagtga gagaggttat attttcctaa gcctcgctta 31800 aagcattccc aactaacaga ttttctgttt ctaatggttt gaacttttgt ttttaagttg 31860 ttatttgggc atgtggttgt agggcataga ttatctccta atttattgct ttcttaattt 31920 gacattggaa tttagacttc agaaacaaaa aatgcaatac tttgaattat cttctttcca 31980 taagttcctg atttaaaatg aaaatgtccc cttaactgct aattacgaga tatcgtataa 32040 agcatatgat acttacagta tatctttttt ggttgtttta taagatgaag attacaaata 32100 tgatatttag cacatcctgg ctcttcttga aagcagggac tatggctctt ttactaaagg 32160 acaaatagtg cctaaggaaa caggagggtg taggagaaag aattcagctt tgtggtcaga 32220 tagacctggg gggttgaatt tcacttctct ctagctgtat ggtgttgggc taaacactgt 32280 ctctagagcg gcttcctcac ctttcaaata gggatgatac tcctttaggt aacgatgtta 32340 ttggtaggat ttgatataat aagtataaag tgcctaaaac aatgcctgta aatggtaatt 32400 tctattagga tggatcatag atttaggatt agaatttaca ctaaacctac cttattcata 32460 gatttgtcca gaatcatagc aggaaatcta ctccataaag tagctctagc ctctggtgcc 32520 tagtagaggt gatgtattag gatagtactt taaaactttt accccaatta agagcagagg 32580 aaaatgaatg gctagattag ccatcctgag ggtttaatct gaaatggtcc atagaagaca 32640 tatcattttc tttctgaaaa acttatttca actttgcatt caaatataaa tatatatttc 32700 aatataggta tttcttcccc tcattaaaaa gtctttaaaa ttgttgttcc aggaagatga 32760 gtagtattta tcttgtaaca ttgagttatt atacccaggc gcactaccag gaacacttct 32820 gatgtacaag tgccttcaat aattgtttca gaagcacaat tttgagataa gttaaagtgc 32880 cctgggaaag agcattgttt atttttggag ccttagccca aaatgactcg gactcatgct 32940 acaaaatgat aacgctcttc atcagttgta tagagctcct tctttatggc cagctttcct 33000 agagatattt tagacttctt tagatgtccc caaaggcaca ataaccacgt aagaagggaa 33060 gccacaggaa ggcagattgc agcagaaaat gaatggtcag ggttctctag gggtggctgc 33120 actgcctcca gtggtggtga gttctccacc tccagagagt gagacaccct tgactcaagt 33180 tttagatgag agaaacaatc aagcagcctc tgaagttccc cttgaattca aattctttgc 33240 atccagaaga gaagtatttt gtgaccagaa agatacagat tgactgcaat tgaccttttc 33300 tatgccagac cattggttaa ctgaagagag tagactctcc agacaggcag tggactcagc 33360 ctacaccaaa acacacagca agccttctgt gcctttcccc aggacagtga ctcttctttt 33420 ctctctgaag ctgtggttct atgtaggaaa ctacataggg tgaagctaaa aggtaggatg 33480 ggccagccta tgtagggtaa ggctttttaa ctctatcgca tgggcagtgt gctgacattg 33540 catacttttt cagcacctct tcagatcggt atataaagta gattaacctg acagcagatg 33600 gcggttggtt ggaggggcct gcagtaaagg agagcagttt ggagaatgcc acggcatgca 33660 gacgcacact gtggagctga gcactcagtc ggtgatgtgg ctcactcacc aggggaagga 33720 cagaggtgag atagggcaag agtcagttgc tgaagtcact actccaaagg gctagataga 33780 aaggtaggga ggaggaatgg agagccagaa aaggagccaa aatgattagc tattttacta 33840 gagcaggtct gtcctaaagg cttggctgcc attctctagc tgggaccttg acgaatcact 33900 tcctccctag tgcctcagtt ttcttgtctt caaaatgagg atgatgctac ctatcctgaa 33960 gggttattgt gaggattaaa tgagatgatg gggtgaaagt gatttgtaaa ctaggaagtc 34020 tatcatgcaa accgcatgat agacttcgga tagaggcagc aggtatacct ttcagctttc 34080 tgtcttgcca aatgaacatt tgtatcctct cacctggtgt ccaagatgaa ggtgctggtt 34140 cagtgagata actcttatcc agcctaatct caagacttcc tttcatgctc tctctctcac 34200 acctagcaat aaatgccaaa agcctaatag ccccccaaac cttgatcgtt tcaagaggat 34260 cctttcaaag gaaacctgcc tttcctctct ccttgaggag aaaccaaagc agtccagtga 34320 ataaaattca tatttttctc ccaggctgat tgaaatggct ggccgtggga gcccagggcc 34380 tttttgtagg actgttttat ttatttattt tattattatt attatttttt ttttgagaca 34440 gagtctcgct ccgtcaccca ggctggagtg cagtggcaca atcttggctc actgcaacct 34500 ctgcctcctg ggttcgagcc attccggatt cgagccattc tcctgcctca gcctccccag 34560 tagctaggac tacaggtgcc tgccaccatg cctggctaat ttttgtattt ttagtagagt 34620 tggggtttca ccatgttggc caggctggtc ttgaactcct gacctcaggt gatccacctg 34680 cctcagcctc ccaaagtgct gggattacag gagtgagcca ccgtgcctag cctggacttt 34740 tccaattagg ctgtgccggg gctgctgtga aactgttttc ctgtgaagac agtgattttc 34800 tccttagggt ggctgctgtc acacggcact gcccctttcc ttataatact tgatcacaga 34860 cacagtaaca tctgtgccta gatcacaagc catacttact caggacgatt ttcctcttaa 34920 agcaccaggg agggagaggc ccttgtcaga attctcacga ctgaatcatt gccatgagct 34980 aatgtctcca gttttatgag tcagtgctgg cccaggcatc ggttttgtag gtttaaaaaa 35040 aaaaaaaaaa agacatgggt tagactcccc taatatcagt agcttgttca gggggaaagc 35100 aaactgagct atcatcagac agcagcattt tagaaatcag atgtttggtt cctctcctct 35160 gtaaggatat agaataagtg gaagaatttc agaattaaaa ataatagtaa taaaagctct 35220 ctgatttgtg cgtgtgtttt gttttgcttc tggcaaagaa ggtaaaatgg tgtgtttggg 35280 agatgaatgt tcttgtaata ggcaagatgt agcttgcagg agaacatctg caacaaaccc 35340 ttattctgca tgagatacag ccaagacctg tttgtgtgtt agtgcctgtt caaacatgtc 35400 taatttttaa aatgatttat aaagttttgg aggaatcacc ttaaaatgtt atttcctcat 35460 ataataggca tatacattca cagcgtggtg gctaaactat acaccctgtt ggagtttgag 35520 cagtgccaat attgagctaa gtgatataaa aatggttatc aatatgaagt agatagaaaa 35580 gtattaggaa tatctgcaat cattcgtgag tctaccgatt aatccagcag caggcaaaaa 35640 taaattatgc tttccacgtt tttaaatgtt cttggtagag aatttatgca aagaataaaa 35700 gggaaataca tggatatttg cttcaaaata cccagaggta ttgctcaaaa cttgattaaa 35760 aataaaataa cagaattggg gatggacgtc aataagaaag aataagctta aataatatca 35820 gtatctatta aacaacatga tttttaattg tgtcttctct attctttccc tttatcatat 35880 atttacacat aataggaaat gccttttagg aaagatagtg gaagccttct cttttgtttt 35940 taacagccat tgcttatgta gtgctaatgc atcttcttaa atccacgtgc tttaaaaaaa 36000 ataatatttt atggtagtca tgtacttctc aacacatcat ttggaaagaa agttaggggt 36060 atgcgctgta atttgtaccc agtattcaga gtttacaaga aagattgctc ttccctgcag 36 120 cctctccacc cttccccctc cttctctctc tcccccactt gcttcttgct ccttgtttct 36180 ttctctgaag aaggacgtga gctacatgga ggacagggca gaaaagggaa gaaaaaaata 36240 ggaaatggtg agaaaaatat taaggacatt taaaacttaa agttttatgg ttctttttag 36300 ctaaatgaat cttttgagct tccatggggg aaattagtgt aattaaaatt ttctagttca 36360 taaaaccaaa tctttacata ctgactgagc ccactgtaag tattgactaa ggcaaggaca 36420 aatgttatcc tctgacttgg aaaattcaaa agaagcattt tgtctcttaa atgaaggtag 36 480 gttgattata tttgatgagc ttcttggaaa aggcattgat tagtccacat ccagaaattt 36540 aacttccctt ttgcttatac tacttgaaaa atgattttat ggacaccgtg atgtaaacaa 36600 tgagtctctc taggaaggga tactgtgtat attttttgtt ttatttttaa ctttctggca 36660 ttccaagaca catacagttt ttatttgagg gaaatattcg taaaatagaa tacgaaggaa 36720 ctattccaaa gtcaggagtt gagtgaaata tcccaattaa aaaactgaaa ggattgttta 36780 tcagtaagtt gcaggatatg tgtagagctc cacaacatga aaattcagta ttaataattt 36840 tggcttgaaa tattttcagt tctatctcct tataagcttc agaattacta accaccgaaa 36900 ctggtgtaac taagaggacg catagcatga gtctcatagg atctctccaa ctggtgcctt 36960 gtaattttgt atggtatgca tgtgcacaca tgtcccaaga tgcgtttgtt gaggcttagt 37020 tgaaggcccc atactatgag gtctcaaatg ttagagttca ctgaacagca cctttagttt 37080 caacatgcat tttctaagca ctggaaggta cacattgaag aaaaacagat ataactccac 37140 agttgactag ctgggttgac taggcaagtg acctgatgct tctgagactc aattttctct 37200 tctgtgaggt gaaaataatc tccattgaag gcttttgaaa gttcaatata tgaagcccat 37260 aatatagttc ctgccactga gcagggcctt gataaattgt gctagttatt attaaggcta 37320 gacactattg ggtaattata ttaatagata agttagccct ttctcaaaga gctcacagtc 37380 aagaagggca aactgataaa cctagttgta atttagtgtg acaggtgcta taatctgtct 37440 ggaatgttcc cctagccacc accacctctg tctgccatgc agactcctac ttattcttta 37500 aaactcattg gaagcattaa ttgtagatga acacttgcct tgtgataccc accccccacc 37560 agctccccct tacagacacg tactcaggag ttcagaggca gtagctttga cctttcatct 37620 ctgggtctta gtgctggcac atataatggg tcttaacaaa tatttttcag gtaataccta 37680 ttacctaaac aaagtggaat gtagtacaga aaactgattt tgctagtttc acagaaaact 37740 ttgcatttaa agttgggcct tcaaggataa gcaaagtctt gggaaaaata agaatagata 37800 ttccaggtag agggaccagg gtaagtaaag gcatggagac atgaatgtgt tatgtaagtc 37860 taggagtggg aagcagtttg gtatacctgg accatagaaa gtttgcagga acaggagtag 37920 caggaaatga ggctagagag aagtccacag agccagattg agatgggctg tgaataccac 37980 cctaaggagt ttggctctag tcctgcaagt gttaagaaaa catggaaggg ctgtgagttg 38040 ggagatgaca tcatgttctg ttggaggaag ctaactggca gcagtttgga ggtagggaga 38100 ctaaaagcag ggaggctaat tggaaaggtg ttgcaatatt ttagataaga gatatggggg 38160 ccaggtgcaa tggctcatgc ctgtaatccc agcactttgg gaggccgagg ctggtggatc 38220 acctgaggtc tggagttcaa gaccagcctg gctgatatga tgaaaccctt tctctactaa 38280 aaatacaaaa attagctggg ctaggtggtg ggcgcctgta gtcccagcta ctcgggaagc 38340 cgaggcagga taattgcttg aacccaggag gcagaggttg cagtgagctg agatcgtgcc 38400 gctgtgctcc agcctgggca acagagcgag actccatctc aaaacaagca aaaaaaaaaa 38460 aaagagagag agatacggag atatgggcag gcaaagggga aaggaggtga gtgtggggtt 38520 tggggtggtt ttgcagtata tattttagag atagaaacct attttccgta attgggatta 38580 ttttgactcc taccattgta acattttcta gacattggtt ttagaggtac ttcttataag 38640 gactgtacca agaaactagt tgaatgatat attcctcaag gtttggggcc tttttggtgc 38700 catgctttgc tttctttagt taggattagt cttggctatt tatccttctg ctttgactat 38760 gagaagaacc acatacctgt aattggtcag acaaaagaac attttatatt ctctatgtct 38820 ctgccttgca ctagaaatgt ttgggtaaaa aatttattgg tttaagaagg aagaaatgtg 38880 cccaaatagc caatgattgg cttgatggct ttggctaggc cgttttgctg ctttgagctt 38940 cagttttctt atctgtaaaa gaaacatatt gagctaaatc ttgatatctt tttcctattt 39000 cttaacgtgg tatggaagtt aacactttcg tccttttact gaatgaaaat aatctaatag 39060 tagcttaaag aaaacggaag catctttcac ttcagtgttt tgagcgtaat gaaatgaatg 39120 ctattattat aaatagcagt accattttac aaaatcagaa gctaggaaaa tgtatttggc 39180 ctttgactcg tggttggtcc tcagtgaatg ttcagtgaat agaattataa aatctctttg 39240 ttcttttttg ctgagtacta aagaccataa atttattaca gatgatattt actgataata 39300 aagtactttt atttttactg gtacccaaag aaggattcaa aaatcttggc agataccata 39360 ttaccaaatc taactatagg agctggacca agagagaaga ctctgtaaat cacctgtcta 39420 cagacccaag acccaaccat cttaaaagag gattcaggaa atcatttaaa tgtttcttcc 39 480 tgctttcatg ccttgaacat gctgtttctg agcaatacac tacagagatt gccctaattg 39540 acactaaata tgagttttaa gcatttattc tgaaaactag acccatgtaa acaagttagc 39600 atccaactat caattcttag aaaatctact ttccctatat gtctactgga ttatttgtct 39660 cagatcttag gggaggaagt ggaagagctg gagaacagca cgtgttattt tagagttata 39720 actggaagta tttggaatgg cttctatgaa agtttatttc actgaaaatg tggaaacagc 39780 tttggaacta aggaatgggc agagactaga tttggaggag cagggtacta aaagcctaga 39840 gtctggcgag gacttagaag agaaaaagat tctggaaagt ttggagctct taaagaaaaa 39900 taaaaattta cttcacttct aactatttgg ttggtgcaaa aataattgca ggttttgcca 39960 ttactttttc accaactaac aaattcagtt tcaaagattt ctatactgct gacagttttt 40020 ttcaaatatt agccctttta attatttcat taccagacca atataacctt aatttttttc 40080 aaccaagata aacaattttt ctgcagtaaa tttgtattta tgttccagac acatctcatc 40140 tgatatacaa tattttctta aattgtataa agagaaatta ttgtacatcg gatgagctgt 40200 gtctgggatt aagtattagc tccactgtaa ccttcatttt cttgaacact ggaaagaaag 40260 gccaacggtc atttagtagg gttggaatag gatggggaat ggggctttgg tgagagagca 40320 ttggactgtt ggttatagaa acacagttca agtatatctg gagttcagat ttgagatctg 40380 actaggagaa tctgtctagt gaaaaaagct agacctttac aaattgtagt caggagctac 40440 cgttgtaaca gtctgccaga gttcctgata caaaagattg ataatttgtg tgtttgaaaa 40500 acaaaacaaa acaaaacaca tctaccttca atttgactta ctgcaactct gattttcatg 40560 gcaagggata gagacaaaat tcattctata aaatttgaaa aaaaatgtat atcctgaaac 40620 cattggaaat tggatatcag cattaatttt attggactga aaaacctcca gtttactaac 40680 aggagttgaa agtcatcact tttcctttca tcatagtgag ttttcatcac aaaccacaat 40740 gatatgctta tctcaaatat attcatttac ttgttttaca caagtatcat ttctgtttac 40800 ataacacgca attttgttgc tgctgctgtt gttttattat gcctgtcact tgagtaaaag 40860 atggataagg taaggtctcc atttagaaat gtatagtctc ttggcaggga agacaaataa 40920 aggcccataa ttatcataac agaaaaatta atatgtgacg caagaaaaaa taaagatact 40980 attaaatttc tttgggactt tgaaggagga agggagcata tagacactta gtaaatattg 41040 tttgaagaag ggaatgaata tgtaaaggga gaataaacct cacctataag gtctagggca 41100 atttaaacac aaaggagttg tgtaggatta tttaaggttt gcaaatgtgt aaaattatct 41160 cactacaata ctagggaaat ggaaaaacac caaagttcct ctaccagctt ttgctggatg 41220 agatgggcca gaagtagtaa ctgcgagggc agcctgtatt tctgttgttg gtgtggttta 41280 tcttcccagt gccaatgctg ccaacttccc ctcaaataaa aacccatagg ggttcagagt 41340 ctcatgaggt gagaacagac ttgcactatc tgtgacaaca acaaaagcac ttataatttt 41400 gatgtggagg atcctaattg aaatctgctg tttgaggttc cttgggtcct gcattctttc 41460 ttaaatattt ctacttgagt tggttattga tccttattta ttttccgtct aatcgattga 41520 ctttataaat ctattgcaga gggcagatta aataggcaga cagttttcta atttgctgtg 41580 agggtatttc ttaatttact ttttaaatac tgattttatt tatacattta tatgcacagg 41640 tcattttcat ttccatgata tcattcgagc ttcacaacca cactccaagt tcagtgttgt 41700 tatcttcatc ttcatgttga ggatgaggac acggaagctc acaggtaaag tgacaaaccc 41760 cagtctttag gctactagat ggtggagttc agactctgat tttctggcca ggtgctcatt 41820 tgatgatagc agcatgaagc tcttcccatt ctgcaccgtt tgagctccta cccttcctaa 41880 tcttctttct ctaatacgag aacactgtaa ttaaagtggt atttggctga taagtagtag 41940 gttttgattt ataacacata gagctggcag tgtaattttt gtcccagaac ttgatgtgcc 42000 atgaaagcta ttatgctctt tttttttttt tttttttttt tttttttgag acggagtctc 42060 actctgtcac ccaggctgga gggcggtggc gtgatatctc ggctcactgc aacctccgcc 42120 tccagggttc aagtgattct cctgccccaa cctcctgagt agctgggatt ataggcatgc 42180 accaccactc ccgcctaatt tttgtatttg tagtagagac agggtttcac catgttggtc 42240 aggctggtct tgaacgcctg acctcatcat ccacctgcct tggcctccca aagtgctagg 42300 attacaggca tgatccacca cgcccagcac tataatgctt ttaatagagg gaaatgaatc 42360 ttcagatgat gtcagcatcc taattttttt tctcctcttg gggtttttct aaatgactgg 42420 caaatggaaa acctgaaagt tacctgagac ttctctgcat cgggcttgtt ggggtatact 42480 gttcttctta taatcaaccc cagggactga cagatggaca gttgttagag acaaagtcct 42540 caatccaagg aggtcactca gggccaactt tccttagtat atatcgttca ttacattagt 42600 tggttatatt acctgtagta caactcaagt acaatagctg caggaggaga cagctcgcca 42660 gctaaaccta aaagttacaa cagtgacata gcaagcaagg gtaaaataaa aggctcttga 42720 cttattcctt cattttttaa taaagcatga agtttgacat aaattttaac ctctggccgc 42780 atagtcagtt atgcttatta tcttgtgtgt attattatgc tgtcaggagt tggccactga 42840 tgaccaactc caaaatttag atgatagaga taaaactggt agttaatata tgttgagtac 42900 caggtcaaaa actccataag acactttaca ctgtgggaac tggttcatgt aacagttctc 42960 caggatggag gattaatatt cccatttcac agatgcagag ttatgtgtct ttctagacct 43020 gacaacacct gtcacctacc aaatgaatag agagctatgc tataagtcta gggatgagtg 43080 atccttggat gcagagcact tcctactagt attctgactt ttactattat gcgtctgtta 43140 ctatttgaca gctctcattt ttgcctgtcc aaatttaagc acgtttaatg agataaagag 43200 agcagaggca aaggtgagac tggatcttcc cttgtatctt attgatagag agtaaatcga 43260 atccaatttg ctaaggcctt ctctctcctt tcatgtttcc tcactttgcc tccaccacca 43320 tgaggttgaa aaatgagttt ccatttagtt taagcctttt gttattcatt acttaatttt 43380 gcttctattt ccctcttcta tctatgacaa attcagcaca gtgaggggaa gaaacagtga 43440 tgatagtgat ggcctcaaga agaaaacagg gtgactgagt aggagcaaat aagtatctca 43500 gaccagcata taaacaagtt catttgtagt gtaaaagaac attatgcctt tggcttgaaa 43560 actgcctttc caatttatga gcatgtttag gattatgtaa gtacagtgtc ttcataacaa 43620 gcccaacacc tcttacccaa agaatgcaaa acgctttgca aacagtagaa ctcacaattc 43680 ccctgtgacc tggggactta tatgtatttt catgcattat tttttataga ttgagaagtg 43740 aacttgagac ctaccaatct gtccacgttg acaaaataga tccaatacta aactcttaat 43800 tccagcttcc tgtcttctta gaagcagatc acactgaaag aggaatctta tgtcaagggt 43860 agcaattttc tctctctctt tttttttttt ttaaagaaaa cacaaattac atagtagata 43920 tatttgcata aaggtagatc ttgaaaacat ttaattaaga cagcggtatc tatttccagg 43980 aaaaaataga aaagccagat ctctactcca ctgaatttaa aaattagagc agcattttgc 44040 agttaaaaac gattattatt ttgcattctg ccatttgtct ttacatgaag aatgcctgaa 44100 ttcagaatgg aaaatatttt cttttgaaaa gtgcatagga aagaattgtt ataaagcaaa 44160 tgtgttcaga atgtatgtag atattaatta taagtaaaag taaaagaagt aggatgtatg 44220 tgagcgtatg tgcatttgtg ttgcagataa accgattttg aaggttgaga gacatgacga 44280 tacttgttag gtatgaggga gacaagacca gaggcgccgg gaagcttgac taccgtggag 44340 agctcagttg agacttgtct ttgcccatgg cctgcagcgc ttatgtagaa attggggatg 44400 cttttactcg ttccaaagcc taacctgatc agacctgccc aggttggagt ttgggaaaaa 44460 aagtgtttga agtaaacagg aaaattactc accttaatga tgtgtcttac tggcactgac 44520 agtgctttga tagtctgaca gtcttttttt ttaagttttg ggaggaaaga caggggaaat 44580 tattaatatg atttttggaa aacatagatt cttatgctta tgcacttgct aataaggtgg 44640 aaaaagtggg ctttgcacca tttacagtta tggactcgcg tttcctccta ataaagtcta 44700 tatcaggaat tttccattag gaatttctac caaaaagaaa agaaaatacg ttactgttta 44760 ttttgtgtac ttgtgccatg tatctccaca attgcgctgt ggctgttcac acagaacaga 44820 ttcttcctag cacttgggct gtgggttccc aaacttgcag gtcgctttca tctgtctggt 44880 gattaagacc ataaaccaag tggtgtgatg agagagtttg gtgctctaga cagagcaagc 44940 acaccctttt ttcataagaa gcacaattct taaatctctg cacctaaatc tttccttagg 45000 atgggtcagt tttttggaaa aagcaattat atatgttttg atattttgtt gaaacataat 45060 agatgttgat ttcatatggt ttttttcctt tttttttttt tgtctttgct aaatgtcaaa 45120 cggtacattt tttctaagct tgaagacaga gaactgggtc atatgtctct aaacatttaa 45180 atcttcactg agatagggaa gagtgacctg atcttatgga tcgtccgagt cctgtgagac 45240 aaaaatgctg ggtttttcat gcagtcccta attcactttg accttggtgg agggagtcaa 45300 atctcctagt ttgagatccc acacatataa agctctagag tttcaggatt aaaatcttct 45360 taactttata ttctcagatt ctgtatagct tattaaacta gatggagggt ctagttatac 45420 tgtctagaag gacatagatg aatagttata ttttataaaa attaaactcc taatgataaa 45 480 aggctaaatg gggagagaat aaattatagt ttatgaaggc atgtaaaaca aaagatgtct 45540 gccaatttcc tctctttggt tctctgactg ggaataactg tatcgttttt actttttttg 45600 tcctaactgt gtcctaattg taaatgaatc tggtgcccag taaaatcaaa tgaatagaaa 45660 tacttaccat ggtgtgtata taccagcctc ctggtgtctc agatataatt aacataatga 45720 aagcattgca atacattctt accgaaggct cagttcctgt cctgtcagca actgtttgcc 45780 tacaactaaa gcaagtctgg gttcaaagca ttttaaaatg ttccaaaaaa gtggggaagg 45840 cggctgggtg cagtggctca cacctgtaat cccagcactt tgggagaccg aggcaggtgg 45900 tcaggagttc gagaacagcc tggccaacat agtgaaaccc catctctact aaaaatacaa 45960 aaaattaact ggccatggtg gcaggtgcct gtaatcccag ctacttagga ggctgaggta 46020 ggagaatcac ttgaactcag gaggcagagg ttgcagtgag ccaagatcgt gccattgcac 46080 tccagcctgg gccacagtgc gagactccat ctcaaaataa taataataat aataataata 46140 ataataataa taataataat aataataatg taaagtgggg aaggcaagat ttggctcacg 46200 cgtcagactt cctatcaatg ggtctatctt tgaagcaagt gctcagagtg tctattcctt 46260 tgatcacacg ggtagtggtt tatttccatg agtatttgct gttttcagga gatttcactt 46320 tgggttttgt ccatattcca cattcaggaa actgttaatt ttggaagaag agattgtttt 46380 tacttggttc ttctaaggaa attaatcaaa tgtacacgtg caacttaaaa tcaaagaatc 46440 cctgttttaa gaggagtttt tcttatttca actggcaaac aatatgaaac tgaatgtacc 46500 caaagtgttg gaggtttaca aacatgatca gcacttgtta atgacaattt tctcctaaga 46560 aaatggaatg ctaccttcta gcatggggac ttgtaggcag tatttctgtg tttgctagcc 46620 ttggaaagta taactcttat agggttgggc aaagcaaagc gtttttgctt tgtaacctgt 46680 agaaatgatt acgtagtgta atttggttat ttaatataat ttgttaataa ttctcattca 46740 tctaccagaa acttaaaact tggtactatc ctgctaattt ggttttggta atgtctcttt 46800 tccctaattt taatatccct gttccttggc aaacccatcc atacacctac ctgttgttca 46860 actggtgtga taagccccat cagtgctcct agacattttc ttttcctact cttcctcttc 46920 agtgtcaggc agaaggatct ttctaacact cgcctcagtt catggattgc tgatggtcca 46980 ttgttggtga ctgcatgatg acctgtaagc atgtcacact ctgaccaaag tgtttgtatt 47040 tggcccaatt ccccacggct aataataatc cctttctgtt tggaaaatgt cttatatttt 47100 tcaaaacaca cacatatatg tattatcaca tttaatcctc ataacaaacc tgtcacattg 47160 gcaggtgtta ttctcacttc tcacatgcaa agttatgtaa cctttcttga gattatacct 47220 cagtttggaa agtaggggaa tgagccttct gcctctgtga gtaccgtgtt cttcacggtg 47280 tacgatgctt ccaaatatat actcttccca acaggcagag gtggtgtttc gcagtcaaca 47340 aaagatgatt tttgttttgt tttcccttct gcatgccctg tctcctgcta cttcctctgt 47400 tcaaaacatt ttttttttct ctctctctct ctcctctcac tgctgcctac caaaattatg 47460 tcacataatt tggctattta atgtaatttg gttaataatc ctcatctatc taccagaaac 47520 ttaagagttg ttatcatcct ggcaatctac cttgaagatt ggcaaaatgt tagttaacta 47580 ttgaatatag atgatgagca tatggaatta aatttgaaat ttccaatttc aggttccaaa 47640 aatccaattt caaattaaga aattttaaat ttaaatctta aattaagaaa tttaagaaac 47700 ttcttaaaat ttttacttat cctttctagc tagagttgcc agatttagca aataaaaacc 47760 aaggatgtca gttaaatgtg aatttcaaat aaaccatgaa aaaatgttta gcataaggga 47820 atcccatgca atagttatta cttttgtttt attttgtttt gttttcttga gacagagtct 47880 ccttctgtca cccaggctga agtgcagtgg tgcaatcatg gctcactgtg gccactacct 47940 ctcaggctca atcagtcctc ccacttcagc ttcctgatgg ctaatttatg tatttttttt 48000 ttctttaggg acaggggttt tgccatgttt cccaggctgg tctggaactc ctgggcttaa 48060 gcaatcctcc cgtcttggcc tcccaaagtg ctgggactac atgcatgagc cattgtgcct 48 120 ggccaatatt ccttacttat gctgaaaaat ttcattgctt ttacaattaa attttaatta 48180 ggctggagat tatctggtaa ccccattccc agctcaatca ccaactctct aagcagaagg 48240 aaatttttca tctctcttgc catagtgagg tcaggattag tgaggtgaca agattaaata 48300 tgagctaagc tatgacactt gttttccaca gtttcctgag cccccctccc tccttttctc 48360 tttcttcctt cttacctccc ttcctctctc ctatttattc ttcctacctt tttgttgttg 48420 ctgtgagtgt cttcacctgt ttccttcctt cctttatatt cctggtaatg tttcaaattt 48 480 attggcatgg gcagcttctc ataataggtt tgtttttatt atttttcttg ttattactaa 48540 aacatgttaa tagatagatt ctaactctat ggcacaacta agacagttgt gttacattct 48600 tttccgtgtt ggggctaatt agaatattaa gtttacaaag aatgcagaaa aagcgaacaa 48660 gatgaagcac gtttccgtct taaacaaatg aactctaaag aaataggaag taacatgatg 48720 acaagctttt aagagatgtt gcaagtagag gaaagggttt gtttaaatct ctccccaagc 48780 accccctaca cctaccccca gccaacacag atgcttatgt attagtggcc cacacggtac 48840 ctaattatca acgatggaaa tagatgtctc aaaattgttt caattatcca ggggttccct 48900 taaaaaagga gaggagagca aaagtttaaa acttggcttg aaggtattaa agagcaaatc 48960 tgatctaatt gattaagtta cacctttcct ttttggcagt atcttaatac ccctaggatc 49020 tcagtatttc agcatattgg tttcctgtac ttatctagaa taaagaaact cagcaatttg 49080 cctataggat agtagagcct tgaactaaat ttatctcatt attgttcact tgaaaccttg 49140 gggacagctg tagttgaagg gaccttaaag tcccttaaac ttctcagcat ttgcaggttc 49200 acttttaagg tgcactaaaa agcaactagt atcctaagct aaaaaaaaaa aaaaaaaaaa 49260 aaaagaaaaa gaaaaagtag atttaagtat accaatgagc atggactctg tttatgtttt 49320 gaaatccatt tgctactcat tttcctcgtt tttaaatcct attatattta cacctgggca 49380 tccatttctc tgaagagaga agaatgaagg atctaaaatg tcagaataac agtgattctc 49440 aacaattatt gtcggcactc tttcatgaag agatttaaag ctctttgctt atctgactta 49500 attcctgccg gaaggacagt acagagggat tacggtttaa atattgcagt tagaagcaca 49560 aagtggaacc tggacttccc cgaccttgga agaaaaatag taaagtgtgg ttcctataaa 49620 atattatagg aacttcagac atagaatgga gcatccattt atagtgattt aagttccagt 49680 attgaaacag gccttctatt tttatttcaa tctccctccc ctttattttc tttgttttgt 49740 gattcacccc aaaacgtatc ttcttatacg gtaatattaa ctagtacctt agtcaaagat 49800 tgatctccag aagtttgttt aggaaattcc ttgtgttact tgtctagcag ttaaactgcc 49860 tagtggaaac aacagctcag ctaaatagtg tgatgcaatc gtgatagctg ctgttcatca 49920 ggcatttacc ctggaccaag cactgtaccc tgaatatcat gtggcttttt ctccacactc 49980 aggacaagct tgcagtgggc agtagtatta tctcagcctt gaaatgagtc acacaaggtt 50040 ttgcagcaga gagaactgtc ctctttttca gccctgtaca ggggaggagc aagggtgctg 50 100 cagtgagggg atctggagtt gaatctggct tagtagctgt gaaagattgg gcaacttatt 50160 tcacgtttag gagtttcaat ttacttaact ggcaaatgga ataacaatgt ctacttcaca 50220 gcttactgcg atgatcatat aagacataaa gaacttagcg aagtgcctag actgtagatc 50280 acagtacgtg ttagcttttt gtgttttata catcaagcgt aagtcttatt ttttacatct 50340 gtcatattac cctttcccca gtattcagag tatttgagtg tatacgtacg ggtggtaagt 50400 gttgtttttc attgaaagtg cagatcctaa cttttttttt catgcagtaa tcctcaaaaa 50460 ggtagacgtc taccataatt cagtctattg ctccaattgg aggatgtaca gttgttttag 50520 gagttaagga attgagtttt ttcttttttg cttttcgtct tttttttttt tttttttttt 50580 tttttttaca aattctttta ttcttttctt ctccaaattc aggcaaacag tattaaacac 50640 tttgttttaa aaatagattg tgtacgtgtg tgtgtgtgtt tatgagagag acagagagag 50700 agatgggaga gggtgagaat acacagtaag gacttggaac atattctttg tgtgaaatgt 50760 taaaaaattg ttcacggtgg ctgggtgcgg tggctcacgc ctataattcc agcactttgg 50820 gaggctgagg tgggtggatc acgaggtcag aagttcaaga ccagcctggc taagatggtg 50880 aaacccgtgt ctactaaaaa tacaaaaatt agccgggtgt agtggcaggc acctgtaatc 50940 ccagctactc gggagcctga ggcagagaat tgcttgaacc cgggaggcag aggttgcagt 51000 gagccgagat catgccactg cactccagcc tgggcgacag agcaagactc agtctccaaa 51060 aaaaaaaaaa aaaaaaaaca actattcaag gtttcccaat aaccttcttg ggctttgaag 51120 ctagagagcg ctttggaatt catgctccat tatatgtgtg tcttaatgct atatactgtt 51180 gtaggtcagc aatatttata tacataagtt tatatatatg tatatataga tcttttgtaa 51240 atagagggtg gatactttgt ccccaccttt tcccatccta gcatgcagta taatgatttg 51300 aacacggcaa ggacaccaca aaggcacagg aagacatcct gcaatgtaca tatagtatgt 51360 gccttatgta cagtaagggc cctgaattta aagttaaaac ctagattgga gaattctaac 51420 tttgtgttat cgtgagcaaa gtagtttact taagtctctg attctgattc ttccttgaca 51480 gaaagggaat acaggtgact ttcttataga gttagctgag gattaaatta atagctgtat 51540 gaaaatgctc tataaactgt taaggactat acagatgggt gagtgatggt gtcatttatg 51600 gaaatcagta gatgccatta ctctccatac tgtcgataca tagtctccca tttcttctta 51660 tcagactggc ctacctagtc ttccggtaaa aagaatatcc cgcagataca aattaccatt 51720 actggaacag aggactcact tttagagcag atgtacaaat gaaactccaa aacaagccac 51780 aaatctacca ggaaagagaa ccaatatgtg tggtattata tcgccaagga tacctgagtc 51840 atttcataga aattgagctg tgagtgcctc ccagaatgaa tggtttctga acgtgtttct 51900 gttaggaatg atgcaacctt cagtagagac cagagattta agaattctat actgtgagtc 51960 attttaaaag acaatcaaag agtatgtgtg gaagcataga caataacttt cacctctagc 52020 gtccaggtgt tgaaggaggt cagctaccag ggaaggactc ctacgacttt gggtgccact 52080 gcgtgaggct ttgtcttgga ccagggggta aaacatatct caggcaggac gctgagctct 52140 aggtagggct atcgtttttg tagaagcgtg acttcttgat acaacaaagt aagagctgag 52200 gaaggaacag ggaaaaccag tttgggccca gaggggaaag aaatgatagt gtagtagccc 52260 gcggttttgc aggcagttgg gagtagcaag ccacccttag ggggaggata atgttttctc 52320 taccttaagg gaaaatgata gctgacttgc agagcagtgt gctgagacag acatgctgct 52380 actgcagtgg aagggggttg caacgtattg tcttctgtct ggagagagag agagagagag 52440 cgcgtgtatg tcacgtctgt gtccataaag ctctccgatc tgcccaccaa ccctgtcccc 52500 caccaataac atcttaaaga gaagaggtac aggaatgttt tacagtgaaa agattacagg 52560 gctggaaatt agaagccaca agttctaatt atgtctcatt gctaacttct ggtgtgatat 52620 tttctctggg tctctcattt atcggggagt taaactaggt atgtccagta ggggtgaggg 52680 gtaagagttc tctgcccatc cagggtttct actagaagaa ttttgactct acagataatt 52740 gtgtcttcct gtattgctga ggaatgtcca ggtttgtttt attgaggggc aggggagcac 52800 atagatgtcc agtagtcagg aaggtggttt gcaggccttt aatcagcact gagaagaggg 52860 aaaactaact gcagttcagt tctcagttcc accattcact ggagtgctgc tttcaacttt 52920 tgagctcctg tttctacacc tctaacgtat cagtgtcatc tcaccctggc ctttttctca 52980 tgatggtcgt gactttagga aacatgtaag agtaagccga ccttaacacg agtacctgct 53040 gtatgacagt cactctgaca aatgcctccc agtgtctgct ctgtgaaggt aactgtgaat 53100 gatattactg gtcaggtggg gttgacagag gtggccctgg caggagacac taaatgaaag 53160 gtcattttac cctcctgggg agataaagtt gcaaaattac cgatcaagtc tgtcaaatct 53220 ttttagactg ggtttccaaa tccataccct caggcaacta gaacaaggct ggcgagctcc 53280 acccccgccc cttcccaagg tgggtgccaa catgctgccc ttcagcaggg aggacacagc 53340 tgcctctggg gccagtgccc agggctagcc acaaagctgg ctatggcctc cccaagaaga 53400 cccaggacac attactccct gcagaggttt tgctgctttg tggcacggtc taagtgtcgc 53460 cccactccca ccacctgcca ggcccagtgg gctcctggct ggtcctcacg gtaagtgagt 53520 agcagacagc ccacctgctt gatgtcaaca tttgtgggcg cggcccggga agaatgtgcc 53580 gctcccagcc tccttggctc aggtaattaa tccccgcaac tgacaggtgg caacaggcgg 53640 ccctttggct ggagccatca ggaaaagtgc ttggaggaag gattttttta aaaaaatgat 53700 caagagcaca attcgtacat gtctggcagc tagacggctg tggcaggaag ggaggcaggg 53760 agaagtaaat accttgccaa gacgactgtg gggccaatgt tgggatctgc gtctgcctga 53820 tcattgtgat agatccaaaa ggatatggtg gccttggact tgtttgcaag ctcactttgc 53880 agaattcccc ttcctttgat gtggatacag tcttaaaatg gaatgcctca tttgtgaatc 53940 aaaaaatccg gggccaaagt tggagcccca gaggagaaat aatttgccca agatgatgca 54000 gtaagtcagt gggcaggtag aggactagaa gccaaactca atgcctcttg gctttgtttc 54060 catgattcac tgggcaatat ttactgcccc attatacaca tgtagtttag aaatagaatg 54120 acaaaactgg ggtcctagtc aaaggaagga tgatcagttg cctcttgaaa gatattagtg 54180 ttttcaatct aaccacttaa agctgacttc tcaagagaat gcccccaccc caaccccaga 54240 ccacctgtac ccattcaccc cccctacttt ttatttttgg tagttcggga cactgactat 54300 cagaacacat tgacctgatg tttattagga tggatatatt aaaagccatt gaaatgaaca 54360 cttttccttt ttcttttttt tttttctttg agacagagtc tcgccttgtc tcccaggctg 54420 gagtgcaatg gcatgatctc agctcactgc aacctccacc tcctgggttc aagtggttct 54 480 cctttctcag cctcccaagt aggtgggatt acaggcacgc gccaccacgc ccagctaatt 54540 tttggcacga cctcagctca ctgcaacctc cgccttctgg attcaagcga ttctcctttc 54600 tcagcctccc aagtaggtgg gattacagac atgtgacacc acacccagct aatttttgta 54660 tttttagtag agatggggtt tcactatgtt gtccaggctg gtctcaaact cctgacctga 54720 ggtgatctga ctcggcctcc tgaaatgctg ggattacggg ggtgaaccac tgcacccggc 54780 caacactttt taaacattac attttttaaa aaataatatc tttctcgata tgaaatttaa 54840 aatgtttttc aagtgagttt ttttgtagag gacaaatcca aagtatagta tataattagc 54900 ccatataact tcatgtgata atcagtgtct ttgaagcaga ccaaactgaa gctgtgtctc 54960 agcgctaagg gtctttttac attttactga attggatctt tagaattaat ttttcaaacc 55020 ctccttatca aaagttattg ttggaccctc aaatttttat tttcatgtat ctcatttctc 55080 ttccctaaat cttgcctccc accagattag ctgccagaac tttatctggt tctctggcaa 55140 ccctccatct gttttgtatg atttttcatt cccagcagtt ctaattattg atttcatcac 55200 cctcttaccc ttataaaagg acatttttaa tttggcagtc ccaaggaata tagcttataa 55260 aaagaaaaaa aattaagtca ctgaatgttt taggagagca ctaagttaag acagactttg 55320 tacttgatta acggaattgt tctgagagct ttagagcttg actttttttt cttcctgtca 55380 agtattttgg gttatttgag atagtacaga caacacttta cctcttaagt tttttgaact 55440 agaagccata aattagaagt gcacctggca tttcctgttt gtgactagtg gctatctttt 55500 agataacagt gaagtcctca atgtccttga taggttcttg gtaaactgcg accttaaaca 55560 aaatgatgtg caggagatct tcgagtaatt gtttcataca atgttatttt cttataacag 55620 tgatgagaaa aacaaattgt tttgttatat gtgttttgct taaagttaca gttcccaaaa 55680 atctatcaaa aatgttaaat gaggattcat tgtatttgta aatctcatta tttttctctc 55740 ttttttaaag aaactaaatt caaattcatt cagaaagcca ggcataaagt gagactaata 55800 tgttcgttgg tgtatttaag cctttcttag agttttcttt tttttaagac ctcagtataa 55860 gaacatgcca gacgtgaatt gatctggaat tgcagactcg ggagggcttt gatgctactc 55920 tatctagttg ccttccttga agagggattg agaagagagg taggttatag aattaatgat 55980 ttttttttgt tccgtgagag tttatttcat ccatagtctc taagatttag ggctcaagat 56040 agccatgtga tttgagattt gcatgtagta tggcatttct tctgggagag gatgaaagag 56 100 ctaaagttct tgttttttgg ttttggtgta gtaggcaggg agggttttga ttctaccttt 56160 aggaaaggga ggtgttgaaa aattacgcag gtgtgtgctg atattacctg gcacctctat 56220 gcattgtgat actgaattac cagtctgcca gccaaaagcg tgtaatatag tatgtctact 56280 gaggcaggtg gtaaaggtag ggtcctagtc actggaattc tttttttttc ccccttctct 56340 ttgcaacata ttattagtaa aggagctgaa tttacttgtt ttccaaaatc ccctggagtt 56400 gttttatttg aacatgatat ttggctttaa gcagctcacc cctcgatatt ccaaacttcc 56460 tcccctccct cccaaagcaa aacaaaattt aggcaaagct tacttatcca ttttgacaag 56520 gatattttat aaaaagaagg agtttagttc atttgttagt tttcaggaac ttcttttcca 56580 tgtcattgtt gaaatattta gttcatgtgg atggccaaaa ctgtcatgtc agtatacaag 56640 gaaatttggt tgaagatcag tacaatatta ggctcatcat tcttgcccat gggctggtgc 56700 ttcctgggaa tgaacaaact attgaatata tgtacagtat gtatacagaa gaacatatat 56760 taagttctac tttatatatt tatacatata tgatcagaaa tggccagtag ggtgtgtgtg 56820 tgtgtgtgtg tgtgtgtgtg tgtgtcatca gaaagattac caacactttg ttttccacat 56880 tctttttttt tttttttttt ttttttgaga cagtctcact ctattgccca ggctgtagtg 56940 caatggtgtg atcttgactc actgcaacct ctgcctcctg ggttcaagca attctcctgc 57000 ctcagacttc tgagtagcag agattacagg tgtgcatcac cacacctaat ttttatattt 57060 ttagtagaga tggggtttca ccatgttgtc caggctggtc tcgaactgct gaccttgtga 57120 tccacccacc tcggcctccc aaaatgctgg gattacaggc atgagccacc acgcttggcc 57180 ttccacattc tttattaaag agtcactttg ccagtgcaaa tctggtaact gcgttctcta 57240 agagatttgc accaaattat aaaataatca aatgaggccg gacacagtgt ctcacgccta 57300 taatcccagc acttctggag attgaggcgg gcggatcacc tgaggtcagg agtttgagac 57360 cagcctggtc aacatggtga aaccccgtct ttacccaaaa tacaaaaatt agctaggtgt 57420 ggtggcgggc gcctgtaatc ccagctactc aggaggctga ggcaggagag tcgctagaac 57480 cttggaggca gaggttgcag tgagctgaga ttgcaccatt gcactccagc ctgggtgaca 57540 gagcgaagct cagtcttaga ataacaaaaa taatcatcat catcatcatc attatcatca 57600 aatggaagta acactataca ttatctattt tcccctctat gaatgattag ctcaagattt 57660 ggggggatca tgtaagttgc cagttatttc tcagtgagtg tcagatattt atgacttctt 57720 tgaagaggcc aatcgttttt gaaaattatt tcagatgtgc tttatttccc cccacccatc 57780 acagtatttt atttctgatt tcacttagat ttgcataatg caaagagcca cagttgcact 57840 gggggtcctt tctaaatagg caacgaggtt agtgcaaccc actgctgact tattgaaccc 57900 aggacctgat ggagtagagt tgattcttaa agcaatgagt gggcattttg tgttgttttt 57960 atgttcaagc tcccattgtg agaatatggt tacactttag ggaagaaaac ctcaactctt 58020 agacaaactt ctttgcttaa ctaaaaataa gtatatatac tcctgtaaga atttggtgat 58080 catattttta tttttgttag taagatggcc tctgagcttt acacttgatt gtctaatcat 58140 atattttcta atcatgtgtt tattcactca aattcactct ggcacgaata caccagttcc 58200 actttggcct catactataa ctgttaaaac tgtgtgggac gtggggaaga acactggtct 58 260 gtatgtcaag atggtcccag ttactgagaa cttttgagca aatctcttct cctttctggg 58320 gcttagattc ctcatcggcg aataaagtgg ctgaaccaaa tgatctttaa ctttgaattt 58380 tcctgatcta acttttcctt ttccttttcc tccctctgcc tcctcctcct cctcctcctt 58440 ctctctctct ctctctctct ctctctctct gttgcctagg ctggagtgca ctggtctgag 58500 gatggctcac tgtaacctca acctgctgca ctcaagtgat cctctgcacc tcagcctcct 58560 acagatgccc ccatacctgg cttttttttt tttaattttg tataggcaga gtcttcttgt 58620 attgcccaga ctggtctcaa attcttgggt tcaagcaata ctcctgccta gacctcccaa 58680 aatgctggga tgacaggcat gagccactga acttggcccc tgatctaatg ttctaaaaaa 58740 atcttagcaa atgtgtgtta aactaaaaat gctttgaaat gggatgactc agtaatagaa 58800 acatagaacc aagcccttgc tttaagatgt caagttggat ttctacagaa attctgtaat 58860 tagaatataa tattgtagta aaagcattat cttcatagaa ctaaggaaat ctgagttcac 58920 ttcttcatta cccaaattta gttgtgcaac ctttagaaat cattttatca gggatgcact 58980 cctgaccctc tgtgatatca tgaaatacgt atttggactt tgtccaagtt tcttggcata 59040 taactcctaa aatccttgga atttccaaaa tgctgccttt tttgtatgct aatgctggct 59 100 catgggttca gaatgggggt ctggtcactg gaaaggcaaa ggcacaatta gagagtcagc 59160 cccacccccc agcctccagg aaggagagag aggctgaagg ttaagttgat caccacttgc 59220 caatggttta atcaatcatg gctagataat gaaaccttca taaaaaccca aaaggacagg 59280 tttcagcaag gttcaagata gtaaaacatg tggagagttt tagaggttga agcccaggga 59340 gggcatggaa actctgcacc tctcccccca taccactccc tagatgtctc ttcatcttca 59400 tcctctgcaa catcctttat aataaaccag taaatgtgtt tccttgaatt ctgtaagctg 59460 ctccagcaaa ttaatcaaac ccaaattggg gtcatggaaa acccaatttg aagctggttg 59520 gtcagaagtt ccagaggtct ggatttgctc ctggttgtgt gtggagtctt gggaactgag 59580 tcttcaacct gtgcgatatg acagatctcc gggtagacag tgtcacagtt gaattggagg 59640 acacccagct tggtgtctgc tgcttggtga gtggtgaaaa actcccacac atttggccac 59700 agaagtcatc ttctgtgttg atgattgttg ctgtggtaat gtgagaggag aggaaaaaac 59760 acagtttgag catttcccaa aacatcctcc aagctaaata gacccccatg ttttaccttc 59820 tctccttttg cttttttttc aagacatgtg tcacaatttt agaaattatt ttttttaatg 59880 tcagtacttc ctttggatca actcccttag tgtaaggttt accgttggtt ccctaatagc 59940 caggacaagg actggcatga agcgcgtgct caataaatat ttgctgaatt aataagcttc 60000 acctctttaa gtctcagttt tatatcagaa aattaggaga agaaggtttg gacaagaggt 60060 gctataatgt tccttctgag ttctaacatc ttctgtattc tctgtcttct aaaatcatag 60120 gtctgtaaca agtttacagg ttggtgctac tcataataat ttatgtatta aacattttaa 60180 gtgagaaata tttcaaggtc aggtgtggtg gctcatgccc tataatccga gtactttgac 60240 aggctgaggt gggtggatca cacttgaggt caggagtttg agaccagcct gaccaacatg 60300 gcagaacgct gtctctacta aaaatacaaa aattagccag aagtggtggc actcgcctgt 60360 agtcccagct gtttgggagg ctgaggcagg tgaattgctt gaacccagga ggtgggtgtt 60420 gcagggagcc aagatcatac cacttccctc cagcctgggc aacagagtga gactccatcc 60 480 ccccgtaccc cttcccccac cgccaccacc aaaaaaagaa ttatttctaa cgtaaaaaaa 60540 gtaagtaaat taagacatct gagtataaga caaaatgtta acatttttcc atattgcttc 60600 aaatcttttc cttaaataaa atataaagca aaaagtactc ctccattcta tctcatttcc 60660 cttctttcag ccattaaaat gaataaaata tacctgtata taagaacatg gataaatctg 60720 ggaagcatgg gaattgaaaa tagattacta aggctaaatg taggatgatg taaattaaat 60780 tttaaggaca cggggaggga tagcgttagg agatatacct aatgctaaat gacgagttaa 60840 tgggtgcagc acaccaacat ggcacatgta tacatatgta acaaacctgc acgttgtgca 60900 catgtaccct aaaacttaaa gtataataat aataaaaata aaaaaaattt taaggacacg 60960 caaaattata ttacatatat ttatggatgt gtattaaaaa tgtatgggag taaataaaat 61020 tcttttttta taaatgaatc tagtaatttg aaatggttaa gaacttaatg attattaata 61080 gataaatatg aattgtgtga tttattttaa atggttaaca ttcaaacttt agcagacttt 61140 tactatgtca acaaacactt tctcaccagg ttgagataca gttttcacag tgctgtctta 61200 aaattactta agctatgtta aacactttat gtggagaatc ttagaaatat gaggcttcag 61260 tcataattgt tatacatgac ttttattttg atctttgcag ttgagtaaga attttttaat 61320 ctattttttc tttcacctta agagatgtga actataattt tttccatttt atatgtgtaa 61380 tggtgaagtg gccaaaatgt gggttagatg ttattgtatt tcaaagcgag cttgggaagg 61440 ggcgcaaagc agtctgcctt taaatgtgtt atttccagcc aggcgcggtg gctcacactc 61500 gtaatcccag cactttggga ggccgaggca ggtagatcgc ttgagcccaa agagtgagag 61560 accagcctgg gcaacatggg ggaaaccccg tctctgctga agaaaaagaa aaatagaaaa 61620 aaaaattaac cgggcgtagt ggtgggcgcc tgtaatccca gctactctgg aggctgaggc 61680 aggagaatca cttgaacctg ggaggcagag gttgccgtga gacaggatcg cgccactgca 61740 ctccagcctg ggtgacagag cgagactctg cctcaaaaat aaataaataa aataaaatgt 61800 gttagttccc ctttggagca gaaagaagtg gacactttta taaggtaagg agggaagtga 61860 acaagggcag gcggtccccc tgctagcttg gtgcctcatc tacctgatag ttgagttggc 61920 accaacccgg gcagaaataa gttgtgaaaa tggccaagca ggcagactta agatatgccc 61980 ttctgatggg tgaaagtccc aaggccaccc cgtgaaggtg aaagttccat ggcaggtgtt 62040 ctctggtttg caaatggact atcagctctc caggagagat ttgtcttgga gcacacagtt 62100 agaacttacc ctgcagggag tatctggtga ggaggacgtg aagggttata tttgcatttc 62160 tgaagggcta agtaggaaac agggaacggg aggaaagggg acaggataag agaaaataat 62220 aaaaataata gtaactcatt cctcttttct tagaagaaat gggagtactc agttaagact 62280 acatgaaggc agagggaggg aataaaaaga ggaggcagaa tttaaatagg attttttaac 62340 tcctagtcca ataaataaat gatgcccaca gttgttggtg ttggacaaga gtctgttttc 62400 tgttgctttt agatctgaga actgagccct ctccttcaca acaaaattgg cctattaatt 62460 ccagtgttac ttcatgtaat ttttttattt gtccagaact aaaactatcc tttctctatt 62520 gtcgacaatt ccattggcta agccaggttt caattgtctg ctgaatatca ggagctctgt 62580 gttaaaatta actcattcat tctgctttga ttttagaaaa cagataaaca actgatagta 62640 tttttgcaag catcttttgt tctaaagcat aatatgtatt ggtctgtttt ggtacttcca 62700 tgtatgtatt tcatgttaaa accaagaagg ctgaatttag taaatccaaa gagtttcccc 62760 catcattttc ccttttcatt catttctact gccctaggtt gggccttcct catttcttgt 62820 ctgaatagct cctgatgggt ttccccaatt ttactttgct tgttcccacc acctttgtat 62880 ttctgaatac aaagaactga ttaggtcttt cccctacctt ataatcctca gtgacacctc 62940 tttgcctgct catagtagtt aacggtatct tgtgacatcc aaggctcctc agaatctggt 63000 aagtgccttt ctagctcagc ctcattgact tctgctcggc tactcctcct ccttccccca 63060 tcccatctat atttcatcca cagttaacat ccccttgctt ttactgatga tattctgtct 63 120 tcatggaaag cctactgttg tctcctggct ttttcttcct ttctttcttg ggtgcacaat 63180 ccaattggtg aataataact tcttttttaa ggcctagttt aaatatcact acctctatga 63240 aaattgtctt ttctatttta attttctctt tcttatccca gccagttcat cagctaatct 63300 ggtgacttct catcacctct actgctggtc taagccactc tcatcttaca cttggattat 63360 tggcaggagc cccctgactg gtcttcctgc ttccgtcttt gttccacaaa gtctgtcctt 63420 cacataacag ctacagtagt cttatagaaa taaaaatcag accacatcag ttgctcaagc 63480 ccctctagtg gcttcctatc tcacacgaaa aaagctcaag acccgtcctg ctctacaagg 63540 ccttgcgtga tctgggctcc ctattatctc tgatcttgga tcttaactcc taccactgca 63600 ggctttgctt acttttctgc aggtgcactg gcctccatgg caagcatacc cagccaggac 63660 tttagcactt gctgtctcta gtacttggaa cactatctct ccaggtatat atatggccca 63720 gctcattatt tcctccagac ttttttcttt aatatcatct tattgaagaa ttctttccta 63780 acaatcttgg aaaaaataat atcctcttca cactcactcc cctgactctt ggctttttat 63840 actctatccc ctttgaattt accctgattt actttttctt atagcactta tcactatctg 63900 acatagtagt tatttgttta ttctagaatt ctagcatttt tagggcatag actttgtctt 63960 tgtttaatgc tgaatttcca aaactaaaac agagccttgg taatagtata tgctcaataa 64020 aaatcaaatg tattacctag tagttaattg ttctatctct gtaatcccat aacacttgca 64080 gatggttcct ttatacccag tgtattttgg ttgtttttgc tgtactctgc ctctagactg 64140 tgagcaactt gaggataaag atcgattttt ttctttcaat ttattttata tttcaagtac 64200 catcctaggc agcatggata cataaaattc tgcattccag gattttaaag tcttacttct 64260 atctgttccc agtacagaat aaggacctag cattgtgcaa tacatgctca gtaagagttg 64320 gctagattaa gtattgaatg ttgtacaaat gagaagagct agctctcatt tgtggtttat 64380 gatggcaact gactagcagc ttttagtgta gtctctccta tgttgttgtt tttatgtttg 64440 tttgtttgag atggactttt gcttttgttg tccaggccgg agtgcaatgg cgcaatctca 64500 gctcacggcg acccccgcct cctgagttca agcaattctc ctgcttcatc ctcccgagta 64560 gctgggatta cagacatgtg ccaccacgcc cagctaattt ttttgtattt ttagtagaga 64620 catggtttct ccatgttggt caggctggtc tcaaactcct aacctcaggt ggtccacccg 64680 tcttggcctc ccaaagtgct gggatcacag atgtgagcca ctgcgcccgg cctctcctaa 64740 gtttgtatta aaatattaat attacaaatt ccagaaaaaa ttaaactaaa ttggacactc 64800 aagccattgg cagaatttta taataatttt atgccctaaa agcctgatag gatagaactg 64860 aaaaatgtca aaatgaaatg aaagctgcaa acactagctg tggctatatc ttgctatgtt 64920 catggaaaag taaaaaagcg agaaagggct tatattaaaa acaaacaaaa tcctatctat 64980 aggggaacat cgttttaaat actcaagaaa atcaacttag gaactggaag aaatatttag 65040 aagattactt tggtgcaaat taataagaca gtaacactgt aaagttggga agacatggca 65100 aacctaaaat tgcaggctga gatgtaaaga ggactagtaa aaagggatga agattaaata 65160 aggaaggaca tttgaaatgc agcagaagaa gtgaaagtat tatttgtagt agaatagagc 65220 agaattaagt gtagaaaacc atacacatac tgaagacaaa tttaagaagc tttcccaaaa 65280 tgcaaacaat aggaaaaact gcataaaata tatggcggat agaaagtgga gatcctaaag 65340 taagacttaa cgtgtttctg gaaactgata cgagcagaag aaacaaaaat acaattgaag 65400 aacaaaatgt attgaggtca agcatgaaag ttaaaaggac ccaccaattt ccaagtaact 65460 tccattttaa aaatcacatt tagagacagt gccactttat tttttaaaaa agataaacaa 65520 aattctacaa gaaactatgg aaaaataagc agcttactta atttaaagaa ataaaattca 65580 gattgacctt ggacttttct acactgaaat gtacattgac tcaattactc tgttttaaga 65640 gatctatcta aagccaattt atatactaaa ctgtgctata tggtgttatt tttaactgga 65700 gtaaaattta tacagaagta tactaaatta tactattcta ctaaaaagtt acaattaaat 65760 aaataatggt atatcccttt ttaatactgt gacagccacc acttaaaatc atgttttaaa 65820 attagaacat gctcatgata tattaaatta taaaaagaat accgtctttg tattatatgc 65880 ccctagtttg tgtgtatata tgtgtgtgtg tgtgtatgta tgtatgtgtg tgtgtatgca 65940 cagaaaacgg tcaacaatgt taataatggt atgtatctct tgagtaagca agaaatcatt 66000 tttttccaga attctgtgtg cacatgtttt gacaatgatg aaatattaat aaaaggcaga 66060 ttgtagaaaa agagaagttg gggagacgtt gacaaaagtt ttaaattttc tgtaacggct 66 120 tctcatagtg acaacactac agggcaaggt actttatacc ttcacataga aggtttgaaa 66180 tatttgctat ccacccaaag agctgctgga aatttaatac aatgggctgg cataatcaaa 66240 aaagttctta gctatagaag atattttttc aggtataaaa tcaactgagt acttaattta 66300 atgcctataa gtaggagaaa cctacataga gatataaggt aaccctggga atagcaatta 66360 aaaaatctgt ttagaatggt aaagaaatgt gtaaaggaga aaataagttt gagctagaaa 66420 tggaacccgt gaaacaagca gaagacctag agaattaatt ttcttaggaa tgtgagtaag 66480 tgttgtattt gatatactgg ttatgaggac tgataaaaga tttaaaagaa atgcttcaca 66540 tatgactcag tattaagaat tagatatatc aaaactttgt ggacatagct aagaagtacc 66600 tagaagaaac ttggtagaat taaatgttta tattagaaaa aaacgtgaaa gtctaaaatg 66660 aatgatatat gattctagtt caaaaaaata gcaaactcaa ccctggtttg attattgcag 66720 tcacataaaa ataaaaattt aaaggtatgc agatttgaaa ggaagaagta aaactgtccc 66780 tgttcatagt tgacatgatc atctatgtag atcgtaagga aggcatctac aaaaagctac 66840 aagaactagt aagtttacca aggtcatagg ctacatggtc attatacatg aattaattag 66900 gtataaatac atgacatagt ataaaacgca ttagaaacaa aaagaaattt tcatttttaa 66960 aagtactgtt tataacaatt attttaaaat aaaatactga aggataaatc taacaaaata 67020 ggtacagtat ttatacactg aaaactataa aacatttctg agtaaaatta aagatactct 67080 gtttaaatgg agagatatca tatgctcatg gtttaaaaga caccacattg ctaaggtatc 67140 agttctcccc taaaagacct tacatattta acacaatctc atgcaaaaat cttaccaggc 67200 atttttatgg aaattgtaaa ctgcatgtaa attttgtatg gaaaaatcaa aggatataaa 67260 atagccagaa caatttttaa aaagaacaaa attgcaagaa tcagactacc tgatttcaag 67320 acttactata aagtagatta acccaaacaa tttgaaattg atatatggat agacaaatag 67380 atcaatagga aagagggaag tattcagata cagacatgaa cacatatgac caattgattt 67440 tcaataaaga gtccaaggca gctcaacaag ggaaaatatg caggtaatct tttcaacaaa 67500 tggtgttaga acaattggat atctgttaaa aagagaagaa ttataaaccc ttaactcaca 67560 ccatatacaa caattgactg aaaatatagt tctaaatgga agagctaaga caataaatct 67620 acttgaagaa aacatagaaa atcctcctaa tgtcaggcca agatttctta ggatataaaa 67680 agcaagagct ttcaagggaa aatattgata attaagtatt ttgggaaagc aggaaaaaag 67740 ccaagctaca ggctgggaga aagtatattt ttaaatgtat atctgataaa agacttgtag 67800 ccaaaataca taagggactc ctaaaactca cattaaaaac aaaagcaacc taactgacaa 67860 attaccccaa atcgccaaaa taacccaatt aaaaaatggc caaaagaccg gaatggatat 67920 ttgtcaaaat aggataagca tatgaaaaat gcccaatatc actaatcagg gaaatgcaaa 67980 tcaaactaca atgaaatact acttcattta gaatggctat taacaacaag ataactgtta 68040 gcgaggatgt ggagagaaga gaacctttac atactttcag tgggaatgta aattagtaca 68100 gccattatgg aaaatagtat agaagttcct tgaaaaatta aaaatataac taccatgtga 68160 tccagcaatc tcactactag gcatttatcc aaagggaata aaatcagtat gtcagaggga 68220 tatcttcact cctgtttatt gcagcactat ttgcaatagc caagatatgc aatcaaccta 68280 agtgtccatc aaaggataaa tggataagaa aatgttgtgt ataggccggg cgcggtggct 68340 cacgcctgta atcccagcac tttgggaggc cgaggcgggc ggatcacgag gtcaggagat 68400 cgagaccatc ctggctaaca cggtgaaacc ccgtctctac taaaaataca aaaaattagc 68460 cgggcgaggt ggcgggcgcc tgtagtccca gctactcggg aggctgaggc aggagaatgg 68520 cgtgaacccc agggggcgga gcctgcagtg agccgagatt gcgccactgc actccagcct 68580 gggcgacagc gagactccgt ctcaaaaaaa aaaaaaaaaa aaaaaaaaag aaaatgttgt 68640 gtatatgcac agtagaatac tattcagtca gaaaaacata atgaaatcct gaggttgggc 68700 atagtggctc atgcctgtaa tcccagtact ttgggaggct gagacaggag gatcacttaa 68760 gcctaagagt ttgagacaag cttgggcaaa atagtgagac cccatctcta caaaaaacat 68820 acaccaaaat tagctgggca tagtagtgcg cacctgtagc cctagctact caggaggctg 68880 aaatgggaga attgcttgag tctgggaggt cgaggatgca gtgagccgtg atggtgccac 68940 tgtactgcag cctgagtgac agagcaagaa cctgtctcaa aaaataaaaa aagaaatcct 69000 gatcctgtca tttgcaacaa catggataaa tctgaggaca ttatattaag tgaaataagc 69060 caggcacaga aagatgtaac cacaagatct cactcaaatg gaatctaaaa atgttaatct 69 120 catagaagtt gagagtagaa taggggttac cagaggctga gaaggggaca cggggtgagg 69180 ggaaatgggg aaaagatggg tcaatgggta caatattaca gttagacaga aggaataagt 69240 tctgttctat tgcacagtag gatgactata gttaacagta atgtattgca tatttcaaaa 69300 tagctagaag ggaggatttt gaatgttctt actacaaaga aatgataaat gtttaaggcg 69360 atggatatac tacatatcct aatttgatca ttatacaata tagacatgta tcaaaacatc 69420 acattttacc tataaatatg tacaattctt ttgtatcaat cataaaataa aacctaaaaa 69480 gtgaaatttc tgtgttacaa agggggagaa cacagtctgt attacaattt ttttaactca 69540 aaaggtacaa aatatttgaa cagatgcttc aaaaaatatc aaatagttgt atagaattac 69600 ataagtttgt ttttattttt attatatata aatatgaatg aaataagtac atgaaaagat 69660 gttaaacatt attaatcatc agaggaatgt taatttaaac cacaatgaga tctgcataca 69720 taccagaatg acatcaatta aaataacagc tgacaatacc aaatgctgac aaggatatga 69780 agtcctcata tattgcaagt gacaatgtaa aatggcacaa ccactttgta aaactatttg 69840 ggagtttgtt agtaagcata cacttaccca gcaatcatat tcctaggtat tcaagaaaaa 69900 tggaaatgta catcctcaca aaaatttgta catgaacgtt cataatagtt ttatacacaa 69960 tagaaaaaaa tggaaataat tggtgagttg acaaataatg aagtgctatt caaaaataca 70020 atggaatgct gatacgtgca aaaaccacag ataaatctca aaagccttat cacataagat 70080 tatatactat atttttccat ttacataaaa ttctggaaag gtaaaactag tggaggaaac 70140 aggtacatga ttgttgaggc caggagctag ggaggggatg aactgcaaag aagcaaaaga 70200 taattggaac aggaatggaa atattctata tcttgattgt agtagtagtt gcacaacggt 70260 gtacatttgt caagccatca gcttttgcac ttaaaaactg gtatactttg cggaaaagta 70320 taccacataa aacaaaaccc ccatacaaaa aagaataaat taggccttag aatgaaaaga 70380 atctcaagtc aatgttgagg agcaatttag acgtgaattt tttaaattcc acagagaaag 70440 aaagatagta aaataagcca tgtgtgttca aatttacaat ttctgctgac ttgaatcatc 70500 agggtatttt aaaatcttgc tgtaaatcag attcccatgt tccaatcttg cagaagccgg 70560 gaaaattgga gatgatggtg ctattttgta agggatacgg aagtgggcaa gtctaaggac 70620 ttgtttatac acatagacca gggagactga acttagtact gggtaaaaaa aataaaggtc 70680 atcatggaac agatttgcaa acaatgaagt aaacagaata gcagagattt ggctttgtaa 70740 aaagaaaaaa aagcgattgt gccagaccac ttcagcgcct ctagttgctg aattgcagga 70800 ctggtagttg aaccaaaagc aataaacata atgcatcttg gctgtggtca gatattttga 70860 tttagtcaaa tatgaagccc tcaccactaa aattggaaaa tatggtttgc agtacagata 70920 cagtactagc tgaaaagtga tatctgaatt gtcctggcat gacgtggaga gcagaggaaa 70980 aagagaagtg taccacactg ggaatatcac ttttgttgtt gtagttgttg ttgcttgctt 71040 gttgctttta atttttttag gtttcagatt cagtaggtac atgttcagta ttgttacatg 71100 aatatattgt ataatggtga ggtttgggtt tctagtgtac ctgtcaccca aacagtgaac 71160 attgtaccca ataggtattt tttaacccgc atcccctcct accttcctca tttttggagt 71220 cctcagtgtc cattatttcc atctttatgt ccatgtgtat ccttttgggg tttttgtggt 71280 tttttttcgt atgtttagta gagactggat ttctccatgt tggccaggca tgtcttgagc 71340 tcctgcctgc ctcggcctcc caaagtgctg ggattacagg catgagccac tgtgcccgac 71400 cacatgtgtc ttcactactt atctcccaca tataagtgag gacacatgat acttgatttt 71460 ctttttctga gttgtttcac ttaggataat ggccttcagc tcaatccatg ttgctgcaaa 71520 ggacatgatt tcagggaata gcattttgaa ttttgggtga tgatcctatg gtgtgtttga 71580 agcattaaaa cgtttgtatg ggtagaacat ggggtgagaa atgtgtgtgg gtgggggtgg 71640 aggggtaggg ggaattagag atagataagg ccataataca gagggcctca taaagtcctc 71700 aataaaccat gttaaagagc aagactgtat ccttgaattc ccagaagcag ctggtgtaat 71760 cgtccaggct gtcttccacc tagcccaaag ttttttcaac tctatcactt gctgcctctc 71820 cctaccatta aatgagtaag caatatactg agaaattaat aaaactatgt taaatagacc 71880 acttttgagc tccattttaa tgcttggaga agagtcggta agcattgtaa ttgattcaga 71940 aaagaaccac aatgttggaa actagaaaaa ggtaaacatt tgcatggctg agttaagaga 72000 acagagacat aagaaactgt tattacagga ctaggataga ctcatatacc agttactaag 72060 caggttcttg ggcaagtcct ttctgtacat ttattttctt atttataaaa tagggatgat 72120 aattcaagtc aattatctgt tatctacaat tctgaagttc caagagctct gaaaatcaga 72180 agttggttca gttttatttt gatttcttaa gtttgtggca cactcatttg atggtgaaac 72240 ccaggtttcg tagtcattta tcagttagtg tgaatattta tgaattctgc agaaataatg 72300 tttgatctta tggtgctacc ctaaattctg ctggatacat tcatatgtta tgcaaactac 72360 tatttttcta aaatctaaac aattctggat tctgaaaatt ctggcccctg tggtttcaga 72420 taagagacag tatgcttgta ataccttcct cttagggttg tatcaggata aaatttctta 72480 aggcagaact cagtaaacga tgaagctatt attatttatc attaattaag cttaaaaatt 72540 agattcccac ccccatcccc gagaatgaac aagaattagc acttgacgat ccttaatttt 72600 attcttaatg cttttatact gtactctctc gagcttgatt tatagtatat cagttattaa 72660 aatggaatgt tttccttaag aaacttctac gctgaacact taaccttcat ttctgcaatc 72720 tttacatact tggaaggata ccttatttgc ctttaggtat tagttgacag acttattttt 72780 cagtcatctt tcctaagggt catcttacga aattcatggt tagattatgc gttatatacc 72840 tcctaacgaa aacacgaatg gatatgctta ttttcttcaa gttctcaata aaaggaagtt 72900 cttaacatgt cataaaacaa gttctgtgta agtctttagt taaaagcact agagcaaaaa 72960 tacccatcta gatttcattc agtgtttccc aagtagaatt ttatttttgt ggttgaagtt 73020 tggcatgttt cctatttctt caagctatat aaaacccttt tgctgcgtct aatccatggc 73080 ctgcggacat ggaggactga ttttgcaata cttttctagc attgggaaac ttctaactaa 73140 aaattttgtg tgctggaata cttggaagaa aaggaaaggt catttaaaca aatactatat 73200 tttaaaatga agaaataaag caacatttta aatgtgtgat ttttgttaag atacttgcca 73260 ttagtgagag ttagggtggg acatatcagt aacgaatccg attgccacta tggctctgcc 73320 cccccaccat ctttcctctg ggaggatgtt ggggccaact tacgattgca acctgtgtgt 73380 gtgtttatcc tttgtttgga tacatgttac taggtgcccc actcttggcc agcaattcca 73440 gtgcctgggt ggtttgcctg agcaaagtgc ctgagtggct aggaatgtag agatagggct 73500 ttgacccaga gcacagggat gataaggttt actatagtgt aaggattaga atgaaggttc 73560 tcttctgctt cagaagtggg aagaggaagc aacacaggat gggatctcta tctggttcta 73620 ggtctcaggc tttctccagc ccgttttgcc aacttacaag caactaacca ccactaaact 73680 tcctctccct ggagaaggaa aaatttcact cacttgtgag tgagaagatc tgcatccaga 73740 tcctttctgt gccatgatta gctgtgctac atcaggcccg gtgttttcag gagtttagga 73800 ccaaacagcc cctttcagct cttgcattct cctagtcttt gacatcagaa ggaaagtgca 73860 ggcgttcaag ggagttcttg ttttacagtt tcaagcgatc tgacgtcagg cgaaatctct 73920 tcactctcta acagatattc catcttaaaa aaaatcccat gaaccctaat tcctgtgagt 73980 gtctctaaag tatattaaag actggattaa ttgtaatcta ggcagaaatc tgtctttgtg 74040 gttgttgttt aatatcactc agtacatgcc aatactcttc tttcacttag cttctggtaa 74100 tctatgaagc tactcgtggt ttcattcatt taaacccctc tgagcctcag cttcttcatg 74160 ctaaaggaaa ataacaggaa ataatggcat aaatgtgttt tgataaacat aaaacctttt 74220 gtaaacatgg ggttttattt atgatagcac aaaatattaa tataacttcc tctaataaca 74280 ttgacatacg tcacatctat agtagccagt agtaaacagg cagcatgcag ctctaaaaag 74340 tggacagatt ttcattgttc tgatttggaa tgtaacaata tctcctgttg gttctctcct 74400 tcctttctcc actggcccca actctaagca gtattccact gaactgaaga aactctactg 74460 ccaaattgca aagacatgcc ccatccagat caaggtgatg accccacctc ctcagggagc 74520 tgttatccgc gccatgcctg tctacaaaaa agctgagcac gtcacggagg tggtgaagcg 74580 gtgccccaac catgagctga gccgtgaatt caacgagggt aagcagaatt tgaatctcta 74640 actgttcaac ctccttgaag gtcaagattc tgtgggcatt tttgtttgag acccacctac 74700 ctgattcaga cttctgcact ccgatggcag atcagtctgc cttttttttt tttttttttt 74760 tttttggctg acagtatcta agaataatga taaataaatt catggctttc acagtggttg 74820 aactatttaa tattagtaat tactagatga cctgaactac tggttatctt tactccttcc 74880 tgcttccttc tttttatttt tcttgccttt aaaataaaat aagaggctgg gtacggtggc 74940 tcatgcccgt aatcccagca ctttgcgagg ccgaggtggg cagatcatga ggtcaggaga 75000 tcgagaccat cctggctaac acagtgaaac tccatctcta ctaaaaatac aaaaaaatta 75060 gctgggcatg gtggcgggca cctgtagtcc cagctactcg ggaggctgag gcaggagaat 75120 ggtgtgaacc caggaggcca agcttgcagt gaaccaagat ggcaccactg cactccagtc 75180 tgggcgacag agcgagactc catctcaaaa ataaaaaata aatgaaaaaa aaataagagg 75240 gtgccaggag actacatggt agctattcta cttggcccag gctacagttt cttcagattt 75300 agtgttttcc cagaaagatt ctcaagtcta gaccagttga gacctggaag ggtaagagaa 75360 aggagcacca aatgaaagaa ataatgaaaa aaccagaaga agaaaaagga aaaaaagatg 75420 agaaggcaag taatgggtaa ggggaataaa tagaaggcct agagcatact gtggccaatc 75 480 aaataaagga ctgggagtgg agggatgagg tatcatgaag gccaccttta gacgctatat 75540 ccatgaataa gtcatgcctc atattctaca tctcagatcc tacaacaatt tagcagaaaa 75600 ggtcagcaat gccaagagtt cccttagatc tgatattata gttccatgaa gggagactaa 75660 acagagagtg ctgaaaagtg gaaggtaaga gcaggataaa gcataagcaa tcctcaaaga 75720 gtattgaggg tgccaaaggt gttgggggtt aggatacttt atagaaaaaa tattaaaata 75780 taaggattga taaatataga gagtataatt gtagagaaaa tcaatggaag aagaaagaga 75840 atggatcgga atttaaaaga agaaaataaa gtcaaaattc tctttaaaaa actatttttt 75900 acacattaat ttcaagtcct tgcccacatg gccacattat ccgtacattt atctcttgct 75960 tttcacttaa caatctgcca taaagaatat tgcaatatag atagacttca ttatcagcct 76020 ccctaacttg gtatttcacc aagataacat actatttgta agcgttttcc cattttttaa 76080 acataaaaat tgtttttagt tttaaccata atagatgatg cagcagagaa cattttgata 76140 tgcttcactt tttactttta ttgaatggtt tttgtagact gggactatag gacctaagag 76200 ctgttaaaaa cagctttacg ggtcccagtt cttggagcat cttctttttt ttggagctct 76260 gctaaatatc acaattttat gaaactttac tcagtctctt ttttaaaatt gcatcccttt 76320 tcttacaccc aacttgggac tccttcaaca cacaaacacc agaacgtttc ttatctttat 76380 aatcaacaca atgtttaaaa gttgaggagg aggaaagaag aagaagtgga agtcatatcc 76440 ttgctatctt ctgcttctca gtgtatttgc tggtcagact tttgggcagc attttctcag 76500 ttaaactgat ttttttttaa attaatttgc ttatttccct ttcattttcc aggaagctgg 76560 caaaatttcc tccacgatga ggtcagagat gtagttatag agttccataa agcttgaatc 76620 attaatctta aactccaaat tataggactg ttcccttaac tgtagatgtg cattccagcc 76680 ctttctgttg ctataaaggt tatgacacct tcatgtattt gatatctggc tatgggatct 76740 gttcgtttct tcaaggatgc acattttctt tattatacag actatttctt ttgccaccaa 76800 catcctgttc atgcaatttc attttatttt ctttattttt aaggtaaaga actaactctt 76860 ttattgtttt ctgctctgca ggacagattg cccctcctag tcatttgatt cgagtagagg 76920 ggaacagcca tgcccagtat gtagaagatc ccatcacagg aagacagagt gtgctggtac 76980 cttatgagcc accccaggta aaaagcaaaa aaccaaacca aaaaacaaca cctctatgga 77040 ctgagtagac ttgagagaac atctgtttca gcaacaggga tgtttctagc atctatcact 77 100 gtcttagttc ttgtcatcaa atatataata tttttgtatt tttttctacc tgttctccac 77160 atgctttccc ttcagaatac ctaaatatgc actgaatcaa cttggtaaca tggctctgtg 77220 tccatattcc catcttaagg gcagataaca attgaactgg caattgggtg tatacatgag 77280 attgttttat ccaactggca gttggacggg tagtggataa gcaatagtag tggatgcaag 77340 tgttaccata agtgggaaag cctaagaggg atctcttagc tgaagtttga atgaacagat 77400 gatagatttg taaatctgtt gcatgaagca gagtagtgtg gttgaaagta cactggtgta 77460 acaggaccca agttctttgg tttgctggct tgctgtgtgg accttcggca actctctctc 77520 tctaggcttc agttgcctta cccgtacgta tgtactttgg actagattat gtttaattct 77580 gagaacattt tgagctctaa gatgttatta atggaagtat atattcaaat ctatattgta 77640 ctgttttatc cacacaggga aaatattctt ggagcattgc tactgttttt ggcaattatc 77700 cccagttttc ccttttcagt gatattcatg aaggtggtat agcctatttg aattacatga 77760 tgtggatcag cttacaaacg aacaggatca aagatcacaa aatgttaaag cctgtctcac 77820 ctaaggtagt gttcagtgtt gcaaacatta gctttaagct tccccgcagg caagatgaag 77880 aaaaatctac aacagggttc agagtttgcc cttttaggag gaagcgtatc acttcatcag 77940 aagtggaatt ccttaaatag agggaagaac tgagaaggaa caacgtcagt ttaaaccctt 78000 gttaacacag attatttacc ccttgttttc aggttggcac tgaattcacg acagtcttgt 78060 acaatttcat gtgtaacagc agttgtgttg gagggatgaa ccgccgtcca attttaatca 78120 ttgttactct ggaaaccaga gagtaagtgg cgtatgtaaa attgtcattc tacacaaaaa 78180 atcacgagca gagggcaaag tgaaatcgtg gctgctttat cattaatttt gcatgtgcag 78240 cggagagctt gtcctttgtg ctctaaatcc ttgctacaaa cggttacata aaagatctaa 78300 gaaagtggag acaaaggaag gtgggtaaag ttagaaggaa aaaaagagct agaaaagtgt 78 360 gcaagtcact tcatacctga attcttgaca tttgactgga attgttctga ttagaccatg 78420 gtcctcaagg catttcacag ttttttttaa gtctgcgctg ccttagggga ttttatcctt 78480 gagacatcca ctggcttaac tcaagtttcc ttcaaaatat gtagctaaat acagctgttc 78540 agctaatagc tcagaggttc tttggagaac aaatggaatg ttatttacta atattacttg 78600 tggcatgtta gcacttttgt gttctgccaa gtgcttttgg gtccattctc aaagccgcca 78660 tggctaagct ggtagtacgt tggcgatggc ccatatggga agtggaagtg gtagatcttc 78720 aggggacttt caaaatgctt tgaatttaac tctttcttcc cctttattct aattcctagt 78780 gggcaagtcc tgggccgacg ctgctttgag gcccggatct gtgcttgccc aggaagagac 78840 aggaaggcgg atgaagatag catcagaaag cagcaagttt cggacagtac aaagaacggt 78900 gatggtacga agcgccgtaa gtagatgtag tggccaaatg gggtagggtt gaatcttctc 78960 cagatgttgg agaatggggt gatattggag aagctgcatg ataagacctg tgaccttcag 79020 cagcaagtgg gacgtcagcc ctcagagcca gtgagaatag gtatagcatt gaagtggact 79080 ccaggcatgt actacagctt tacaaaaaca agtagtcatt gtgacaattt ctcagtccag 79140 ggattctcaa aatgtgactt ccacaccagt agcataaaca tcatctattc acagacacac 79200 accagcaaga tacgggcttt cctgcaacat tacttaagcc aaaggctatt tcccagcata 79260 ctgaatttct tttatgtatt cttccctacc atccttccac ctccttattg ctaggatcac 79320 aatcaatgta aaaacaattg tccccagtta aatggacgct tagggctaga gcctctaatc 79380 ttacatgtgt tgctggtact actgtctttt taatatgtat attaaatctg attaacatta 79440 atatttaatt attaagtata tttaatatgc attagtgctt tagaagtgtt cccaggatga 79500 aacttgcatt tttcctccac cagcgtttcg tcagaacaca catggtatcc agatgacatc 79560 catcaagaaa cgaagatccc cagatgatga actgttatac ttaccagtag gtcttccttg 79620 ggtgttcatg gttgcttcat tttaaccttc tttgaatggg cttttacagt atgatcatca 79680 tctcattatc tgtgacaatg ggaaaggagg tgtcttagtc agttgaagct gctacaacaa 79740 actaccgtag actagatggc ttataaacaa cagaagttta ttttctagag tctggaagtc 79800 tgagatcaag gtgcccctat ggtcgggttc tggtgagagt tctcttctga gttgcaaact 79860 gccattttct ccttgtattc tcatatagtg gagagggcta gagagctctc tagggtgttt 79920 Tttttttttt tataagggca aaatcccatt tatgaaggct ccactctcat tacctaaatt 79980 acttcccaaa ggactcacct tctaatgtca tcacaatggg gttaaaattt ccatctgtga 80040 actttggaag gacagaaacc ttcagtccat aatggggaag aggggagacg gttgagagct 80 100 ggtgatacaa aggagagaaa atatgtgttt tttaaaatta gaatattatt ctttctctcc 80 160 acagttttgg actgtattac tagcatgagc ttctctactt acctacccac ccaactaaag 80220 ctaaactcct aacagaattt ttcttaccct aatatttaaa attaatttgt ccttcattat 80280 ttgagaatga taagattatc ctaggcagca tggccataga aatttaggcc gaaaatgttg 80340 tcagaaaaag ttcacaaaat tgataatgca gcaatgatag ccttgacttt gatgtctttt 80400 aggcagcact ataaagaaag ccaagcaagg cagaagcctg aattacagtc agccctccct 80460 atctgcctgt tccatatctg cagattcaac caatcacaga tcaaaaatag ttggaaaaaa 80520 acaataaaaa aatacaccaa tcaaaataat acaaatataa caacaatata gtataacaac 80580 taattgcatg gcatttacat tatattagat attataagta atctagaggt aattttaaac 80640 tatacagagg atatgcatag gttacgtgca aatactacac cattttatat aagggacttg 80700 agcaacctag gattttagta tccatggggg ccagatgggg gtgggtagtc ctggaatcaa 80760 tgctctgctg atatcaaaag acaactgtgt atgtaaatgg ccagaagtct tagcccaatt 80820 attatgtaag aacctcatta attcctacaa gggacattac ttctcttgca atcactaatg 80880 agatcacttt attagattat ggttgcagtt agttagttga attcttattg cattaggtct 80940 ttgccatgta gggtggcaat gacgttttgg tggctggcat agcccttgat gccatctaaa 81000 gcgatgacat gagacacagc caagcagggc caggagattt gaccatgaac tactaccctg 81060 ggattgaact aacgaaagtc aacggattta ggtgtgctgc actttcttcc tcatcttctt 81120 tgggtcctga ctctcagggg aataaattgc cagtagacca atcagacggt gagttagctg 81180 agattcccag tgtcttgttt ctcaaggtat atatggaaac tgacttgtga tgttaaagta 81240 aaacattacc ctgatacact aaatattcca aaagtcttaa tatgttttca gctgataaaa 81300 caggaactgc ttgaaaaatt attttaaaat ttcagtttgt actaagaagg aggtatcctt 81360 cttagtgtca tgtctcaagt tgagagaaga cttagcctaa ataatttatg ggtgaggaaa 81420 aactccatta atttaatata tattttgttg gtgtttggtg agtggcaaat atgctagacc 81 480 ttgagcattt agagttcagt aggatacaat tcttactttc aactaccttg ccttctattg 81540 aggacacaaa cagttataat gtaataaata aatgtaatgt aataaaataa atattcctag 81600 atcaaggcct agtgctgtgt gagtacccaa gaagctccaa agatgcaaaa actataaata 81660 agagtaagat caagaaaagc ttctcagaga aggggtccca cagctgggat gagtaagagt 81720 taattcaaca aaaggtggag aacatttttc atttctgaat tctgactaat tctgcctttc 81780 ctactgggtg cagcaactgg ggtaaggcag ttaaagtgcc tagggtgcaa aatttaaata 81840 gtcactcaca cccaaggcaa tgcagttgtg ctaagtgcct ctcttgcctc actctagtcc 81900 tggcccggct catccgtttt tttggttttt gtttgttttg aaacaggatc tcactttgtt 81960 gcccaggttg gagtgtagtg gcaggatcat ggttcactgc agcctcagac tcccagactc 82020 cagcaatcct cccacctcac ctccccaggt agctgggacc acaggtgtgg gccaccacgc 82080 ccactaattt ttgcacattt tgtagagaag gagttttttt cccagggtgg tcttgaacta 82140 ctgagctcaa gcaatctgtt ccctcccaaa ttgccgggat tgtaggtgtg agccaccatg 82200 tctggcccct gctcataatt gtaaaagcct ttaagagctt ttatttaaag attttaaggg 82260 actctcttaa agagagaaac atattttatc ccacatggaa acttttatcc tatcaaacat 82320 agttacaatc tattcttatt ttttgtagta gtttagtttt atgaaggtgt tgcaaaaatg 82380 gtattggtgg atatgaatca tctcatcgct cctaagagaa atataggatt gggttcctat 82440 gcacctctgg tcacatacat ttcacaacag aataatatat cacttcgttt gttgtgtgtt 82500 tctgttaaga gacattttat ttaatatata ccgttgactc attaacatca gactcgtggc 82560 caattagcct tataactcat gcctgaataa agtttctcta acacacacac acacacacac 82620 acacacacac acatattttc tccataaggc atggaacgac cttctctcac ttagggacac 82680 tagatagcac ttccgcactg cccttgaggg tcttttaaat aacaaaatca ccaatgaaaa 82740 gcacaaaaat gtaaaacacg tggcgctaaa tagaccatga aaagaacgtg ggtttacggt 82800 ataagagcta caagatgaca gagcatctcc ttgttcgaac cagctgggaa tgcacacagg 82860 tgactcaaat ttttcatcac tctgcccggg tctgaaagac cacaaaaggg ccaagagtgt 82920 tgattttcat gttacaaata aacgttagca aataaacaaa ttgcaattac ggaatcctca 82980 aataatgagg attgaccaca cttctaacag ttctacagct tttcatgttt ccttctttcc 83040 ttctgctcac ttccataggt gaggggccgt gagacttatg aaatgctgtt gaagatcaaa 83100 gagtccctgg aactcatgca gtaccttcct cagcacacaa ttgaaacgta caggcaacag 83160 caacagcagc agcaccagca cttacttcag aaacagtgag tgtatcaacg tgtcatttta 83220 ggaggcatga gtgagggtga ctttatttgg atcagcaata gggtgattga tgagcaatgt 83280 ggaacataat gggagatagc agattgtcat agattcagat gacctggtat ggcaaccctc 83340 tttcagttgc aacctttttt acgtgtctta ttataacctt cccttcagaa ttccacttat 83400 gttctgaaat taaatacaaa ccatttctgg tgaattacaa agaaactcac actaacagtt 83460 ctcgtctcta tatgcctggt ccatacacac taacagtaag tacacactct atttggtagt 83520 gatgtgtata tttgaaaaca tgaaatcttt tctcatccca atggattgtc ttataaatct 83580 cctgggatgc acactatcca cttttgggaa taacactgta gaccagggat agcaaatagg 83640 ctttactata atataaagtg acttgtttga atgctgtaat gagaagaatt ctgagaccta 83700 gtgcatgata attggggaaa tatctgggtg cagaaggata aggtagcatc atgttgccgt 83760 attttagaat ctctgctcta gattgtcttc cagcagtaca tttttggcat aaatcaagcc 83820 agatttttca agtatattac catatacata taacctattt atatgttaag ctttgccttg 83880 aatcttggat ctttcctaaa gtgattttat gactgactag aatagaatag ctcttatgaa 83940 aggatgagag gttgaccaat caggaccttg tttatattta cctttctgtg gttaaaaata 84000 atcacttgtt agtttaatta aaatatgata tgtgtcctgg aagtattgtc agagactctg 84060 tagataagtg taaaatatat acattatgag tccacttgag taatgtagac tttcaacttc 84120 atactttagg caaaaaagaa gtcaaaaact atcttccaga ggcaaagatt atattttaca 84180 atagaaatgc aaatgaacaa taaaaatggt tattttctat gttattagct gttgtaggga 84240 gtcagctgtg gaaagtgtaa taaagagggc ttatgattat tattattatt attgagtctc 84300 gctctgtcac ccaggtagga gtgcagtggc actttcttgg ctcactgcaa cctctgccta 84360 gcgggttcaa gtgattctcc tgcctcagcc tcccgagtag ctgggattag aggcacctgc 84420 caccatgcct ggcagatttt ttgtattttt tagtagagat ggggtttcac catgttagcc 84480 aggctggtcg cgaactcctg aactcaggtg atccacccac ctcggcttcc cagagtgctg 84540 ggattacagg tgtgggccac cgtgccggcc ttgttattat gttttaatca atatgaatgt 84600 atctctgata gtaaagaaac actttctgag cacctgttat ctacagagtg gagtagacgg 84660 cagggagaaa agaggcacat tctctgttca aaggactcta agctatttga gcatccaaga 84720 tcctttttgg cccgaaggga tctcaccatt tacttttagc ataaaagttt tgcaaatttt 84780 aatggtatgg ttttatttgt aagcctgagc agaaagttta atcacacagt gtattctgaa 84840 ggagaattag aactcagagt tgcagacaca atttccattg ctaatcatat ggatgttttg 84900 ggatatcaga tggaaatata tactaacata tttaagtgga aaatgattta gttcttataa 84960 aaccatacaa ccaggatcaa agaaacagag acctgtaaca tcatttatag acccaggagg 85020 gatatctacc tttcctaaga tatgtgtgtc atggtattaa gaaataccct caaatttcct 85080 cctgttcact ctgaaagttt gactatacca aaatgacctc caaaacatca ctaagtaata 85140 tatcatgctg aactagttgc tcttcagtac tctttcctgt cttttttttt tttttttttt 85200 cagttaataa gaaaaggtct catatgtagt acaggaattg gcaagctgct ttttgtaaag 85260 tcctggtagt aaatatttag attttctggg tctatattgt cttttgcaac tactcagctc 85320 tgtggttgta gcacagaaac agccgaagat aatgcataaa ggaaagagag tggctgttcc 85380 ataaatggaa ctttatggac cctaaaattt gaatttcata taattttcac atgccgtgaa 85440 atattattct ccttttgatt gttcctcccc ctattaaaaa ctgtaggccg ggcacggtgg 85500 ctcacgcctg taatcccagc actttggtag gccaaggtgg gtggatcacg aggtcaggag 85560 ctcgagacga gcctggtcaa tatggtgaaa ccccgtcgct actaaaaata caaaaattag 85620 ctgggcaagg tggcacgcac ctgtagtccc agctacttgg gaggctgagg cagaagaatc 85680 gcttgaacct gggaggcaga ggttgcagtg agccaagatt gtgccactgc actccagcct 85740 gggcaacaga gagagacttc atctcaaaaa gaaaaagaaa aaaaaataca tacatatata 85800 tatatatata tatatatata tatatatata tatatataaa ctattcttag cttgctgtag 85860 tttgatagtc tgtcttatag ataaatgcgt ggatctcctt tcattgcttc ttgaggctcc 85920 aattttgttt gataggtgta cttggaagtt aatatgtata ttccaagcta gaaagttatt 85980 aaaagatttt aggaaatcct aaagtggttt ttcaggtggc atttcagtat ctaataaaaa 86040 gcaacaccag ccttgaacag atatcttttt tgtctgagaa agtgaggcat gcccatccag 86 100 atataaaatg tagttaacga cacaacctca ttgtcagatg aggctggaat agttgacttg 86160 attcacgtca catattctta ttgaagatgt gctatgtgaa agcattaagg atagaggtga 86220 gaaagatgta gctcctgcct tcccatggtc tacaatttaa tggtgaattt ctaaccttaa 86280 cactctgagt ttgaagaaag ctctggaaat ttatcctcag cattgtgcaa gttaatagga 86340 caattttaaa cagtttccat ggatcatatg agaaaaagaa tagtttcatg tcattgtttt 86400 agaaacttga caagccagga ggattgacat cattcagttc aggggcatat gctaaatgta 86460 tttgttttta tggcatacat gaaaatacat aaccctcttt ttctatacga tgagtatcca 86520 gtgcttattg tctgaccggc tcacattgct ctaaagggaa ttttttattc atatttcata 86580 aaataatctg tgtccccaga gaagaaaaca catgttaata ttgtgttatt tttaaaagca 86640 cacaagattt tagggacata tttacacttt tttgcatgtg tggccacaga tagatagtaa 86700 agaactagta gcttcatagt tccctggtgt gttcatttaa ctgtattata tgcatgcttt 86760 tgagttggta tctcacagct gtgataactt gtgcatggaa atctaacaga ctgcaaaatt 86820 aaatctttgc aaaatataga catttggtct aattatgtct ttgtaacatt atatatacat 86880 gggtctccag tgattgatat gcatctatat aaatccttca gttgaattct tcagctgagt 86940 ttttttagct cttattttca tgcaaatctc caagaaagag catgaatgac taaacaaaga 87000 aaaacaaaaa tctaatttcc tggcaatcat ttgaaaagaa taaatcagct tggaaaatac 87060 ctataatagc ctgtgatttt ctttccaaaa agatagtacc aattttatgc tggtaaggaa 87120 tcaattttgt atttttcttt atagtagagg gaaaattagt gggaagagaa cgtactttct 87180 gtaaggtggc actacaatat ttttacttta attacttcta ttaggttccc actatgtgtt 87240 ttcttctgcc tgcttttcat ttgtgcatgg tttttctttt taaaaaaatt tcttcgcgtt 87300 taccttcatg atcataggct ttatcgaaga tagactttac agagctgctg tgaatcaaat 87360 tgttatagat acaagtaggc tttatattac gaagaaatgt gattttagtt gatttgctta 87420 cattggaata aatatagaga gttatgtttc tagatgccag aatctaatag aaagacaaat 87 480 cggaccctat ctttagactt cttgccatcc tattatcaag ggacatcaac gcttaagaca 87540 gctttgcaga agcctcttga gacctattta gcaacgtttt gacttctgta cttcagatca 87600 gtactatttc ttttttcatt tgttagttgt tttcccttat tcttggcttc caacataaaa 87660 gcgaggctga catcactttg ttacagtctc gcttaggcta gctcttactt tcctctggaa 87720 atttattttt gagcttctac aggatgaatt ttatttaaat gataaaacag atctgtgaca 87780 tcctgatgag cccttagtgt ttccttctct tttatgatta cttgacaatt gtggctcatt 87840 agtaacacaa gtcagagatt attagaacaa agcaggatct ccaagtccat ggttccagcc 87900 cctcacacca tagccggata aactgaggct ctgtgaattt atagccagtt tataataaag 87960 ctaagactag aatcagattt agaacataga gctctttgta atgttgtgtt ctgctacatt 88020 ggcagttaag taagtagtta attataaaat ttaaacatct atttccattt ttctgtctct 88080 tttttgtagg attgttttag agatggggtc tagctatttt gcccaggctg gacttggact 88140 tctgggctca agcgatcccc tgcctcagcc tcccgagtag ctgtggacca caggcacacc 88200 ccactgtgcc tggcacgttt ttctgactct gttgttagtt acttggtatt tattcttgta 88260 ggttcacttt aaagtcctgt atctttaaac ttgtttggcg atggttatca tcaagaatat 88320 tgatattttt ttctcagatt catgtatctg agggagaagc aggcagtatt ttcagtatta 88380 tcaatgtaga aaagagaaag gtacacggtc tccaaactga tagaaaatgt caacaccgta 88440 tttctaggtt agacagagaa atcctccacg tttccagaat atctgaaatt gccagcttta 88500 taggttaaaa agagatgaat attgataatt tcatatgatt cacccttata gttattatgg 88560 aactacacaa gcttttacag tttccttttt tttttttttt ttttttgaga cagagtcttg 88620 ctctgtcacc caggctagag tgcagtggca tgatctcggc tcactgaaac atttgcctcc 88680 tgggttcgaa caactctcct gcctcagcct cctgcgtagc tgggattaca gatgcctgcc 88740 accatgcccg gctaattttt gtattttgat atatatatat aatttttttt ttcttttttt 88800 ttttttttag tagagacggg atttcaccat gttggccagg ctggtctcaa acccctgacg 88860 ttgtgatccc cccgaccttg gcctcccaca gtgctgggat tacaggtgtg agccaccgcg 88920 cccagcctac agtttacttt tgaatttcat agttatgaag ttttcagggc agagatttat 88980 tatctctgaa ttggtaatga agaaaaacca tagagacggg gtttcaccat gttggccagg 89040 ctggtctcaa acccctgacc ttgtgatccc cctgaccttg gcctcccaca gtgctgggat 89 100 tacaggtgtg agccaccgcg cccagcctac agtttacttt tgaatttcat agttatgaag 89160 ttttcagggc agagatttat tatctctgaa ttggtaatga agaaaaaact caatgattaa 89220 ttaaactcag atagattaaa ttacttttgt aacttctctc acctcattgc agaatcaggc 89280 tcagtcctag gtcttagagg tctttagtta gctgtacatt gcttccccat ccatttttat 89340 tcgggcatat tctgttaaga tgatatcaat tcttgccggt gacatggttt actgaatcct 89400 agcattaagc aaataaaaat gactttgttc ctttgaaagg catagccaaa tgtgattcaa 89460 gaagccaatc tgggaaacaa tttccaaaca gttcatgaga ttgcccaact ttcagcaaaa 89520 taaaagggtt tatttctggc atcctcgtgg tgtaaataat ttcttaatta tgcaaaaaat 89580 tgctttcttg ggtttgatat atgcatttat aggccgagtt ttttactcaa aggattaagg 89640 tatttatcca tctcaatctg ggaatatcca aaatactcat taaacagttc tttgtaaatg 89700 cctgatgcca caggccccat tctgataata tcatatttct ctatacctca cacttaggct 89760 agacaagaac tgtaatgagg gataataatt gaccagatga cattttacaa aagattcaag 89820 tttcttcttc ttcattcctt ttttttaatt gagtccagta aaccgtatgc gaagcactgt 89880 gttaaatacc ttgatctacc ttatctcagt ggtcctcgac tgaatcgcct tgtgtaactt 89940 attaaaaata tgttttcctg gatgccagct tgtgttggaa gggagccagg aaaatgcatt 90000 tttataagtt tcacaagtga ttctgatgtt tatttctggt taactactat agccttatcc 90060 catttcttcc tcataaaaat cttgagaagt ctcagtaatt gtaaaagaag ataaattgga 90120 agaacaaaaa tagcttttca ggcactctat tctgtctata ctatgatcat gaaggtataa 90180 ggagtgtgtt tctgaattca attgatttga atagatgaag tcctaggcct tcattttttc 90240 ttttctctgg ttcctctctg cagtctcctt tcagcctgct tcaggaatga gcttgtggag 90300 ccccggagag aaactccaaa acaatctgac gtcttcttta gacattccaa gcccccaaac 90360 cgatcagtgt acccatagag ccctatctct atattttaag tgtgtgtgtt gtatttccat 90420 gtgtatatgt gagtgtgtgt gtgtgtatgt gtgtgcgtgt gtatctagcc ctcataaaca 90 480 ggacttgaag acactttggc tcagagaccc aactgctcaa aggcacaaag ccactagtga 90540 gagaatcttt tgaagggact caaaccttta caagaaagga tgttttctgc agattttgta 90600 tccttagacc ggccattggt gggtgaggaa ccactgtgtt tgtctgtgag ctttctgttg 90660 tttcctggga gggaggggtc aggtggggaa aggggcatta agatgtttat tggaaccctt 90720 ttctgtcttc ttctgttgtt tttctaaaat tcacagggaa gcttttgagc aggtctcaaa 90780 cttaagatgt ctttttaaga aaaggagaaa aaagttgtta ttgtctgtgc ataagtaagt 90840 tgtaggtgac tgagagactc agtcagaccc ttttaatgct ggtcatgtaa taatattgca 90900 agtagtaaga aacgaaggtg tcaagtgtac tgctgggcag cgaggtgatc attaccaaaa 90960 gtaatcaact ttgtgggtgg agagttcttt gtgagaactt gcattatttg tgtcctcccc 91020 tcatgtgtag gtagaacatt tcttaatgct gtgtacctgc ctctgccact gtatgttggc 91080 atctgttatg ctaaagtttt tcttgtacat gaaaccctgg aagacctact acaaaaaaac 91140 tgttgtttgg cccccatagc aggtgaactc attttgtgct tttaatagaa agacaaatcc 91200 accccagtaa tattgccctt acgtagttgt ttaccattat tcaaagctca aaatagaatt 91260 tgaagccctc tcacaaaatc tgtgattaat ttgcttaatt agagcttcta tccctcaagc 91320 ctacctacca taaaaccagc catattactg atactgttca gtgcatttag ccaggagact 91380 tacgttttga gtaagtgaga tccaagcaga cgtgttaaaa tcagcactcc tggactggaa 91440 attaaagatt gaaagggtag actacttttc ttttttttac tcaaaagttt agagaatctc 91500 tgtttctttc cattttaaaa acatatttta agataatagc ataaagactt taaaaatgtt 91560 cctcccctcc atcttcccac acccagtcac cagcactgta ttttctgtca ccaagacaat 91620 gatttcttgt tattgaggct gttgcttttg tggatgtgtg attttaattt tcaataaact 91680 tttgcatctt ggtttatctt gcagtttttt tgtttctgtc tctctcactt tttttccact 91740 aaatactaga atattctcat gtaagtgctt gaagtagcat gtgtaggtct aaggaacaag 91800 aataataata gaatcatcac tttgttccta cgtacatttc ttctgtcagt atttggtatt 91860 tttatttaag atactctgta tcaaggtcat caatcgtaac aaggaactaa aatgcctaaa 91920 ctaacttaaa aaaatacttt agctctatga gttttaaagt ttgtcctagg aagccagaca 91980 ccatagaatc atttattgac attcctgaca aacctctagt tgtatgttaa ttcgccaaat 92040 ttactaaagt gaatttcaat caaatccaaa tgttttaaat aacatggctt ctgtggcata 92100 gacattagca aatatttggc cagaaatcaa cagtggaacc tattgtccaa tttttttttt 92160 tacttatgtt ttgagccctg aataattgct tttaaaagct tcataagaag ttctaaccaa 92220 aaaaaaaaaa ttagtatttt agataaatat ttcagaaaaa aaaatcttta tatttgagat 92280 aaaagtatat tagtaaaacc agatgctcct gttatatttg caaggtgttt ttcaattggt 92340 ctaataactt tgattcacaa agcccttaaa ggattggtga gtatgtttcg ttttttgata 92400 tttgcttttc tttcagaagg gtttttcttt tctttcagcc ttttttaagt aagtttttaa 92460 tgtgtttata gtgacttgta tataaatgca catatttgaa atgatggaaa atattagaaa 92520 attacagttt tcccatctag agaataaatg ctgcactgtc tttagtagcc agataacccg 92580 gctagagaga aaggtcacag gtaggcagta ctgggtaaaa ttgagagaag atatgattct 92640 ttttctgatg gtccatgttt tccctttttt tttttttttt cctgaccttt ctcataacaa 92700 ggatgctctg ctccgccctc agtatccctt tctgctccca aattctttac tgcagaaatg 92760 gtttgttgaa atagatttgg cctaagctat caccaaatcc tactagaggg ttgcttttta 92820 atgagcagtg gaagatttta gccaaaagaa ggaatctagt ggaattctag acatctagga 92880 ggtagatagt gtaacttgtg tctgcgcagg aattttgata ttctaccaca tagatagtca 92940 ctagggttgg aaccagaaaa cctgatttga agtcctatat gtcctaaaac cacttctcgc 93000 ttttcaattt tgaattttat tcttcggaaa ctgtgcagaa gcttatattg ttaaagttaa 93060 gaactgggac ttggctccac caggattttt cttcaaagct ggaaatacgt gaaatatgat 93120 tttctacatc tctgttacac tgaattctta gaaaaatcta gtgaggctct agagaaaaca 93180 acctgaggta tacaccttac gatttttttc tgcagacagc tggattctta cttttttggg 93240 ttttggatag gagaggagag tgtaggcaag aaaaccagaa tggtacaggt cctgttattc 93300 ttctgaacac attttccttc tctttagttt ctccagaaat ttttggaata tttcacttaa 93360 gaactattgt attaaatttg taattttttt taaaaaaggt tgttcttcaa ggctttcaaa 93420 ttggctgagt ttattcagcc ttgcttcctt tttcaccgta tgtagttttc agaatgcttc 93480 ttctagttca gtcattttga aattaataat agacagacta ccttgcttcc cttccgtgtg 93540 gctttaaaac tcactttcat attaaaggga aggcattccg aatttctgac ctttcctgac 93600 tgttaacccc attcaactgt tcaccctcat ttctgggtat gttcaattaa gaatccaact 93660 cacctctggc cacttcctcc tattaattct tacatagtta tcttctatgc catgggccac 93720 atatcagagt gttaaatatt tgaggctgga gggaaacagt gaaagaagct aagaagctga 93780 tgtttcctga gcacctacaa atcactggac cctgtccagg gctgttacat gatctcattc 93840 ttaatagaaa tcttctagag taggtacaat atctaggcta caggttaaga aaatgagact 93900 caagaaactt gtacaacatc ctgcgtcact aagtttgtgt tagatgtttt gattgactta 93960 gaatccatgt tccttctttc ttcatctgtg gtttctgacc taccctcctc aaattagtgg 94020 cttatgatga aaaatggtaa atgaactaat aaaatagtca aaaataataa ccataagcta 94080 aagaaagcag gaggttgtaa caggaattgt aagaaggaat ttactctgag cgtccagaaa 94140 aaaaaaaaag caaaactttt aaatgtattt ttatttttct aattgtggct attaatgatt 94200 caagcactgc tttctattag ctcttgctgt acatttgact ggtttgagga gggacagata 94260 gagaggtctc ctcaggttac agaggaccaa ctgcatcagg aatatgggct acctggaatc 94320 ttaggtactt ttcagtgagc aaagagaatt gaagaaacat cagctggcag agaatctcct 94380 tactgccttg ccccaagctt tcctatactc tgatgtggac taatggatga gcctaagtgc 94440 agccatatgt gctgactctt tgaaaaggtt cccccacagg gacggagtgg attcagaagt 94500 gcttggtagt agctggagtt acctccttta cccctcttcc atcttggtct cctacatttc 94560 tcttactact tcatctattt cttgtcccca taacctagaa aaaacaatag gtgccaggag 94620 acctagttct gccctcagtg catccattta gcaacatgtg atcttgggca tatgtttttt 94680 cttagaacct tatatttacc catatgtata tttggaatag taatttctgt ccatctctgc 94740 cctgctatac catgacctgc tccacaagga tggtgtgaca atcattcaga aaatgtacaa 94800 agaagagttc ggtaacctga aatgttttat agttgggagg atttattgta tcaacaccag 94860 tatatatata caatgtggat ctataattgt gagtatttga taagggctaa agagaaaagt 94920 caatgccctc ctaccttaaa ggcagtgatt gtaaaataca cctgaattgt taatttacat 94980 taattgacat gataatttat acacattaaa atacagcata ttgtttgcat tcatctagct 95040 gtggctctcc attgacatgg aatggagcct tccttatttt catgtaatta tggagagaat 95100 gcagagtggc agcttcgaag accatcccta cgattgcagc acctaagtgc tagggccatt 95160 tttaaaatga tttttttcaa atattatgcc atataggctt ggaacctggg tccatttaca 95220 gagcctccaa aatttgaatt atacatatat atgcagataa aactcaaaga aaaaatttgt 95280 ctcccctcta atgtaaatat gcctgtgaca gggaaaaggt aaacaggaac aacataattc 95340 gctttgtttg agaattgtta aaggggagtt ttcccataac agactagaca cttgcttaaa 95400 gtccagtctt cattctgtgg tcacagtaat tcagtgtaga tgctgcatag tctgtacatt 95460 tcttcctcat cttctctttt tcagttctca tcatagccgt ataaggtagg atggattatt 95520 atatccattg cctccactac tctatgagtg tctcaaagat ggggaccatg ccttaagttt 95580 tattaacttg aacatctgac tcatgcagca agtgtaaatg tatgtagttt atatagtttt 95640 cttgtgagaa aacaaaggcc aggatgttaa gtagctcgca tgggcatcta tagcatccta 95700 acagatgacg gaggaaggct tcatctctga ctttgtgact ctcattgtag tacacatcac 95760 tagtttttat attaagataa aacatcagga atgacagttg agttgggaat attatctgtt 95820 agatataata tgacaaatga gttctggtaa ctttccaaat tgaagatcat gctgaatgga 95880 aaactattgg gtttttctgt tgctttgttt ttttcatttc tcccaggaga cttttggaaa 95940 gtcaatagaa tagttatttg ggcttcagcg ttctcctgtg tagaaatgct tttgacattc 96000 cagtaggttc tctcatacat catgaacatc tctattgaaa atgcatgttt ccaagtaggg 96060 gcctctgcat gacagcaaga tgagctgcca aatgcccagt ttgattgggt ttgtagtcat 96 120 tttctgcata tcccaaatgg aatatacaga aagctacaaa tggaatgcct tagctgcagt 96180 ttgagggtgg gatatccatg tttttcgtca gcctttaagt ctttgctcaa ttcttttccc 96240 taactgcttt tcaaactcat ttgagttgaa gggaaaagag gagaagggaa tggagaaaac 96300 aactgaaggg aaaagaggag gcaagaattt tctctttctc aaaggaaata ctaaaccttg 96360 cactctgcac attcaggaaa aatatgattt gatgatagcc tcgcagtcag tttctcccta 96420 ttcaggaaat attctcagat ggaaacaaaa ttaacttctt accattaatc ctagaagaat 96480 gttttcaaat gtttggtttg aggccatgtt ttaaacagag acctgttgaa aatcaatagt 96540 ccccactctt cagtgtccct tgctcaccat tatttccatg tttgtcttcc taggacctca 96600 atacagtctc catcttcata tggtaacagc tccccacctc tgaacaaaat gaacagcatg 96660 aacaagctgc cttctgtgag ccagcttatc aaccctcagc agcgcaacgc cctcactcct 96720 acaaccattc ctgatggcat gggagccaac agtaagagca tctcctttta gctgtggctg 96780 aaggatgaac aggctagctt aggacaagac tctgtgatgg ggaaggcatg ttcttaagct 96840 aaatgagaga cacagtggga cagatcagat caaagtggag tggcttgggt ttctgactga 96900 acctttcact tttgaggttt atcattcatt gcaaaatata ctactggtag agatagggac 96960 ggatgtttct ttagtgtagg gataaggatt tctgtgaaaa gaacagtcta cttgctgcta 97020 tcctggatgg agactcacca cctgcagcct ttgaaatagt caaaaggaaa caaatgcaac 97080 atgcataaag tagcatgttg cagtgaactt aaaatctaga gaaataggcc gggcatggtg 97140 gctcacgact gcaatcctag cactttggga ggccgaggcg ggaggatcac ttgaggtcag 97200 gagttcgaga ccaacctggc caacatggtg aaaccccgtc tctattaaaa atacaaaagt 97260 tagctgagcc tggtggtgca tgcctgtaat cccagctact caggaggctg aggcatgaaa 97320 atcacttgaa cccgggaggc agaggttgca gtaaggtgag atcacactgc tgcactccag 97380 cctgggtgac agagtgagac tcagtctcaa aaaaaaaaaa aaaaatctag aaaagtagat 97440 tatcgtctgg actctatgaa aaaaatacct ctaattacaa agaagttact tctcgaatac 97500 ttaattttct atccataaaa ttgtcactat atatacttaa cattttatgt ctgttactct 97560 ataatcctgg ccttttaaac tcacctattc tatcccagac acagtcagta aggaactgat 97620 ctacgaagga acctgccttt tatttcttct cacacacatt cctcatatca gctaagtaca 97680 aatgaaaaag gcactgtaag aattgggcct ccaagtggat gatgactggc atatagcttt 97740 actataaata taattatctt ctccactagg actaaatcta gcaaagtgga tacacaaact 97800 tgaaggaaaa aaaagtcgtg gtaaaaatgc aaaagattgt ataacaccct cggggataca 97860 gaagactgaa cattgcatgg gtatcatata atccttacta cctaaaaaac agtaccctca 97920 agcttgtctt ttgaaatcct aattattttg atcaaacctc taaacgagca tttcagtgtt 97980 gtctcttctg aaagaaatca ggggaggcta ggattatgac tttctgtggt ctaatggcac 98040 acattcattg ttttggtttt tttttttttt ttttagacag agtttcgctc ttgttgccca 98 100 ggctggagtg caatggcgca atctcggctc actgtaatct ctgcctccca ggttcaagtg 98160 attctcctgc ctcagcctcc cgaatagctg ggattacagg cgtgcaccac cacgcccggc 98220 taattttttg tatttttagt agaggtgggt tttcaccatg ttggccagac tggtcgcgaa 98280 ctcctgacct caggtgatcc acccacctca gcctcccaaa gtgctgggat tacaggcgtg 98340 agccaccgcg cctggccaca cattcatatt ttaatgagat agaggtgtgt gtgtttgcaa 98400 tggttgcctg ttatggcaaa cgtagacttt agagtgagat cactctctca ctaatgataa 98460 actcatcata aggcttaaaa cctgacccct tgacaggcct actttgacat aaaaagagta 98520 gaaaccattt attttcaact ttattttatt tcttgtgaca tcttagagtc ctcaagttcc 98580 ttcttggtat gacaaaattg tgataatagt gatgatggtt cacatttgta taacttacag 98640 tttgcctact ttttttctta tttgtacttt acaattattt cagaagggaa acagattgag 98700 atgtgatagg gtatgctctt tagttagcta gttagtggca aagacctttt ctaggcatac 98760 tgctactcac taaagtagaa acaaattaca ttaatctttt agtaaattat tttgttcttt 98820 ttgacatgaa ggcaaaattc attttataaa tattgatatt aaactttttt tctctatcag 98880 tgagtgttta cacttaattg tttagtaaaa tatcagtaag tattggtggt gttcctgtat 98940 acaaccctga aaatggacca taagtaatag aatatttaat tgtatcatca tttattaggc 99000 acgtgagtcc ttctaaatat tgaagtcagt ctccctattc ccaaataaat gttccaaggg 99060 tcactctttc attcacagat ttgtgcattt atccacttac cctaagttta ctgagcacct 99120 actctgtgcc aggcactgtg ctagggactg tagggatcta gacacctata agatctaatc 99180 tctgtgcttg cacaggttag tgagggagac agaaatatca ccctcgaagg caaatacaag 99240 gaagaatatg ttaacattaa gagcaattag caattagaga attagaagca gagaaagggg 99300 aggaaagaga ttgttctcgg acaaggtaca aaagtcaaga ggtgcctaat tagtttggag 99360 tctgaccgtt ctgtttgact agatgtaggc tgtttgaagg ggtgtagtga gagcgaagat 99420 taaaaaggaa ggctggtagt ttaggccctt gataaaattt aaccagacaa gatggaccac 99480 tgggatgctg gtacatgatg atggcagtaa ccctttttgt tcctcctgct tctgttcagt 99540 tcccatgatg ggcacccaca tgccaatggc tggagacatg aatggactca gccccaccca 99600 ggcactccct cccccactct ccatgccatc cacctcccac tgcacacccc cacctccgta 99660 tcccacagat tgcagcattg tcaggtgagt ccacagcatg tgcccctggg ggcctgccct 99720 aagcatcccg ggatggtgga gggcggatac tgttatagtc cataaaacag ttggaaggga 99780 agacagcagt cctgtggttg gagttcagtc actattatct ctgatctgtg gagtggtcaa 99840 caatgtttta tcaaggaaaa ctactataac cagcatggaa acaagggaaa gtgtctgttg 99900 ataggcatat tgttttcatg tctgtttccc tcgccttcac ttactccctt cctcctctct 99960 cacattttta cattgtcaat tgcggccctc aagttggtgc tcagggctgg gtttccaaaa 100020 gggcaataaa cttgctatct cgctcctttt cctctctctc taatccttat agctctcagc 100080 caccatggga ccattatttt ggagttggat gtccataaaa agttttaatg ttatccaaaa 100140 tgacagggac tttcaaaaac tgatggcctt tactactctg cctatgggaa atgggcacac 100 200 tccagaaaag gggagttgag ataagcagaa gaaagaaatg catgaagcct gaaagatttg 100260 cttcccacag aggcaagagt aggttcccag atttcttgcc tagtgtatat cttcttcttc 100320 tgcttcatgt gcagaatgat tgtttcattt ggctactgga acgatttgtg ttgattttcc 100380 tgctacgtca atcacaggga tggcaaagtg cgtggccttt tccacccagg gtctgttctg 100 440 taatgatggt ggcatcatca tcagtctcag accagcacca aaaggaaggg gatctgtatc 100500 ctgagaagga cataaatcaa aaggcatgaa tgacttaatg gagtagaggc ctacaatttt 100560 tttcttaacc acatgagcca ttctcacaaa gcccagatac aaaacaaata aagtagagat 100620 gttctttttg aagtgtagag ccaagcagca agaaagctag gaacctgaac actggacttc 100680 cctttcaccc tttgcaatgg ttcctaggac acttacacag aaccctagaa ttccacagat 100740 caccatatga taatcgctga tctgcaggaa tccttatagt tgattttaat ttctgtagac 100800 ctaaacttca tgtcaccagt aatctccaga cctcagactt aaggcccaca tatatattac 100860 ccaatcctca tctctgatgt ggggcatcca agggcaaaat atattgggtt ttcccttatc 100920 tcgccaatgc agttggggtg aactttcttt ttctgtttcc tccttcctct tccctcctcc 100980 ctctgcagtt tcttagcgag gttgggctgt tcatcatgtc tggactattt cacgacccag 101040 gggctgacca ccatctatca gattgagcat tactccatgg atgtaagtaa ctgttagact 101 100 tttctcaaat tttatttctt catttctttc ctctgatgac aaccgccttg tagttcaatc 101160 cctgatagtt taaaaatttg tttttgtcat gcccccaatt atccattttg atagaaccca 101220 taactatgtt agaaagattc ccaggcctca acctatacat attagaagct tagcaatcaa 101280 tcttccttag cttgtcttat cagtcaacaa ttgtctattg cacttacact attctcaagg 101340 tgggaaagag gagctattcc cgcaatcaaa acattcataa tttctaaaga attaatacaa 101400 ctttttgagt gtgctcatta atctgtatca gttcccagaa aggatagcag ggcaccggtg 101460 gtgctattct cttaaaaaca tggagagatg acacagtagt catttgccat gactatttaa 101520 aacaaaacta ggaatagaac acaaacgtgt aagcttacag tctttaactt tattaactgg 101580 ccttttctgc ctttctttaa attagtacct taagggagat tcagccgttc ctctcaatta 101640 aaactatatg ttcctttatt aattttcagt ttcatcctaa tagagcccag ccatttctaa 101700 tcattgggca ttatcaatgg ctatggggtc aaatcccaat cacccttttt agtagcaatg 101760 agaacttggg gttatcactt tgcctctctg ggcctcagtt aataaaatat tgggttcaaa 101820 ttactccttt ctggctttca tatcctttga tttgtctttg aaacaagctg ggcgagaggg 101880 gactttttct tgcttcctac tccacttttt gaactcctgc tcacacggga gctagtgttg 101940 ctctggttta tggcaatctg atttgtctct taggccgcgc tcttcatgct gctctctttg 102000 gggttcacta gcctctcttc tagcttccag agggtacttt ggactgcggg aagaagacag 102060 tctctgcctc tgctgctact tctattgttg gggactcttt tttccccctc cttgagcacc 102120 gatgctagag atgcccctgc agcataagaa tgcccccacc atgaggtgac gtgtacatag 102180 tgtactgccc ctatgcccac ccctcttcac cccataaatc actcctggct gctgctccct 102 240 gatagaataa gttataagca aaaactgcag ggaaagcttt aagagtaagt tccagtatta 102300 ttctgataac tttacagtca cttccgtcca ctgaagagaa cagagttgcc ctatatttga 102360 gagagtctcc tgtagtagat tcctacattt tggaacagag aatcttcctc ttccctatat 102420 ttttaaagtt atactttcca cttgctcact tatttccact ggggaatgtg tcaggatgtt 102 480 cccttgatca ttaggatctg cagataccct ttataagttc atttctgctg atgttgacta 102540 agtcctatgc caatctgtgg gccacagctt tctcacctgt cagtcattag ttaaaatcca 102600 tccagggcat catgacaatg aacagagtct aatttacaaa gagctttgca tttactgaga 102660 gcctcaaaag tataaagaat ccaagaaaca taaaaagcta tgcttattta ggccgggcat 102720 ggtggctcac acctgtaatc ccagcacttt gggaggccga ggcaggcgga tcacgaggtc 102780 aggagaccga gaccatcctg gctaacacgg tgaaaccctg tctctactaa aaatacaaaa 102840 aattagccag gtgtggtggt gcacctctgt agtcccagct actcaggagg ccgaggcagg 102900 aaaatggcgt gaacttggga ggcggagttt gcagtgagcc gagatcacgc cactgcactc 102960 cagcctgggt gaaagtgcaa gactccgtct caaaaaataa taaaaaaagc tatgcttatt 103020 tttttgtgga ttaccttctt tataaggtat tcttctgcta cagtaagaga ttaggaatac 103080 ctctaatggc ctgaaaattc acaccatagg aaaatatgac accagactac aaacttccaa 103140 attgagaaat gttgggaagc tgtgcaattt tctcctcctc acctcagctt cttcctgcgt 103200 atttctagaa agagacaccc ttttctcagc ttttatctta gagccagtct aagttattgg 103260 gcatcatcac ttcctggaaa aggaatgtga cctaaatttg gggaacttca ttagtatccc 103320 cataacatgc aaaaatgagg taacaataca acataataat aatacaaatg gttaatattt 103380 atagagtgtg ttgtaattta taaaatactt tcatagctgt atttacctat gagtctatag 103440 catcttttgc cctataaagc aattgtatct cattttacca aagaagaaac tgaggctggt 103500 agagaataag tgacttgctg aagttctata gccagtcagt gaccatcaaa acctctgcca 103560 cagttttctc actccaagca caatgtgctg tttacctacc attctgccct gtgaaaatat 103620 gagctatcac tgaaacaatc taaagaagag ctaacgcaga taaatgtaag tgatatcacc 103680 acagtcagtt aaggttgacc ctatttgcaa tgccttctgc acccattcac agaacataga 103740 cacagttgct ctgcattttg ataccttgct ttattcaaac accaagagac cttttagata 103800 aaagtgccgt ttcaggttct gaggatgccc taagtcccta attttttcac ttagttatgt 103860 gactttaaac ttgtcaacct ctctggcctt cagttgttct atctataaaa caggtctaat 103920 aatgtttacc actaatctgg ggattaaatg atatcatgaa tataaaataa ttcagggcct 103980 ggcacataga aagtactcaa tcttttcttc tcatctcctc aaccaagtgg tggtgacatt 104040 ccattaatac ctttcttcta gtgactagcc aggtaaattc aagcataagt aggtacctca 104 100 tgtttctatt tgggattttt gccctctcat ctagctatta tcccaatttt accaatgaag 104160 aaactgaggc cagtagagac taagtgaagt gttctacaca ggcaggaaag acacctcaag 104220 gctgtgcctt tgtgcttagt tccatagagt tgaagactca gagaactaat tttattttct 104280 aatttgtgga tcaatagatt cagatcaatt aaaccagagc atcagggaat gataggatgc 104340 tgtggactaa atgtccgttt ttctccctgt tttcattctc catgacacct tcccctgttg 104 400 cacaggatct ggcaagtctg aaaatccctg agcaatttcg acatgcgatc tggaagggca 104460 tcctggacca ccggcagctc cacgaattct cctccccttc tcatctcctg cggaccccaa 104520 gcagtgcctc tacagtcagt gtgggctcca gtgagacccg gggtgagcgt gttattgatg 104580 ctgtgcgatt caccctccgc cagaccatct ctttcccacc ccgagatgag tggaatgact 104640 tcaactttga catggatgct cgccgcaata agcaacagcg catcaaagag gagggggagt 104700 gagcctcacc atgtgagctc ttcctatccc tctcctaact gccagccccc taaaagcact 104760 cctgcttaat cttcaaagcc ttctccctag ctcctcccct tcctcttgtc tgatttctta 104820 ggggaaggag aagtaagagg ctacctctta cctaacatct gacctggcat ctaattctga 104880 ttctggcttt aagccttcaa aactatagct tgcagaactg tagctgccat ggctaggtag 104940 aagtgagcaa aaaagagttg ggtgtctcct taagctgcag agatttctca ttgactttta 105000 taaagcatgt tcacccttat agtctaagac tatatatata aatgtataaa tatacagtat 105060 agatttttgg gtggggggca ttgagtattg tttaaaatgt aatttaaatg aaagaaaatt 105 120 gagttgcact tattgaccat tttttaattt acttgttttg gatggcttgt ctatactcct 105180 tcccttaagg ggtatcatgt atggtgatag gtatctagag cttaatgcta catgtgagtg 105240 acgatgatgt acagattctt tcagttcttt ggattctaaa tacatgccac atcaaacctt 105300 tgagtagatc catttccatt gcttattatg taggtaagac tgtagatatg tattcttttc 105360 tcagtgttgg tatattttat attactgaca tttcttctag tgatgatggt tcacgttggg 105420 gtgatttaat ccagttataa gaagaagttc atgtccaaac gtcctcttta gtttttggtt 105480 gggaatgagg aaaattctta aaaggcccat agcagccagt tcaaaaacac ccgacgtcat 105540 gtatttgagc atatcagtaa cccccttaaa tttaatacca gataccttat cttacaatat 105600 tgattgggaa aacatttgct gccattacag aggtattaaa actaaatttc actactagat 105660 tgactaactc aaatacacat ttgctactgt tgtaagaatt ctgattgatt tgattgggat 105720 gaatgccatc tatctagttc taacagtgaa gttttactgt ctattaatat tcagggtaaa 105780 taggaatcat tcagaaatgt tgagtctgta ctaaacagta agatatctca atgaaccata 105840 aattcaactt tgtaaaaatc ttttgaagca tagataatat tgtttggtaa atgtttcttt 105900 tgtttggtaa atgtttcttt taaagaccct cctattctat aaaactctgc atgtagaggc 105960 ttgtttacct ttctctctct aaggtttaca ataggagtgg tgatttgaaa aatataaaat 106020 tatgagattg gttttcctgt ggcataaatt gcatcactgt atcattttct tttttaaccg 106080 gtaagagttt cagtttgttg gaaagtaact gtgagaaccc agtttcccgt ccatctccct 106 140 tagggactac ccatagacat gaaaggtccc cacagagcaa gagataagtc tttcatggct 106200 gctgttgctt aaaccactta aacgaagagt tcccttgaaa ctttgggaaa acatgttaat 106260 gacaatattc cagatctttc agaaatataa cacatttttt tgcatgcatg caaatgagct 106320 ctgaaatctt cccatgcatt ctggtcaagg gctgtcattg cacataagct tccattttaa 106380 ttttaaagtg caaaagggcc agcgtggctc taaaaggtaa tgtgtggatt gcctctgaaa 106440 agtgtgtata tattttgtgt gaaattgcat actttgtatt ttgattattt tttttttctt 106500 cttgggatag tgggatttcc agaaccacac ttgaaacctt tttttatcgt ttttgtattt 106560 tcatgaaaat accatttagt aagaatacca catcaaataa gaaataatgc tacaatttta 106620 agaggggagg gaagggaaag ttttttttta ttattttttt aaaattttgt atgttaaaga 106680 gaatgagtcc ttgatttcaa agttttgttg tacttaaatg gtaataagca ctgtaaactt 106740 ctgcaacaag catgcagctt tgcaaaccca ttaaggggaa gaatgaaagc tgttccttgg 106800 tcctagtaag aagacaaact gcttccctta ctttgctgag ggtttgaata aacctaggac 106860 ttccgagcta tgtcagtact attcaggtaa cactagggcc ttggaaattc ctgtactgtg 106920 tctcatggat ttggcactag ccaaagcgag gcacccttac tggcttacct cctcatggca 106980 gcctactctc cttgagtgta tgagtagcca gggtaagggg taaaaggata gtaagcatag 107040 aaaccactag aaagtgggct taatggagtt cttgtggcct cagctcaatg cagttagctg 107 100 aagaattgaa aagtttttgt ttggagacgt ttataaacag aaatggaaag cagagttttc 107160 attaaatcct tttacctttt ttttttcttg gtaatcccct aaaataacag tatgtgggat 107220 attgaatgtt aaagggatat ttttttctat tatttttata attgtacaaa attaagcaaa 107280 tgttaaaagt tttatatgct ttattaatgt tttcaaaagg tattatacat gtgatacatt 107340 ttttaagctt cagttgcttg tcttctggta ctttctgtta tgggcttttg gggagccaga 107400 agccaatcta caatctcttt ttgtttgcca ggacatgcaa taaaatttaa aaaataaata 107460 aaaact 107466 <210> 2 <211> 586 <212> PRT <213> Homo sapiens <400> 2 Met Leu Tyr Leu Glu Asn Asn Ala Gln Thr Gln Phe Ser Glu Pro Gln 1 5 10 15 Tyr Thr Asn Leu Gly Leu Leu Asn Ser Met Asp Gln Gln Ile Gln Asn 20 25 30 Gly Ser Ser Ser Thr Ser Pro Tyr Asn Thr Asp His Ala Gln Asn Ser 35 40 45 Val Thr Ala Pro Ser Pro Tyr Ala Gln Pro Ser Ser Thr Phe Asp Ala 50 55 60 Leu Ser Pro Ser Pro Ala Ile Pro Ser Asn Thr Asp Tyr Pro Gly Pro 65 70 75 80 His Ser Phe Asp Val Ser Phe Gln Gln Ser Ser Thr Ala Lys Ser Ala 85 90 95 Thr Trp Thr Tyr Ser Thr Glu Leu Lys Lys Leu Tyr Cys Gln Ile Ala 100 105 110 Lys Thr Cys Pro Ile Gln Ile Lys Val Met Thr Pro Pro Pro Gln Gly 115 120 125 Ala Val Ile Arg Ala Met Pro Val Tyr Lys Lys Ala Glu His Val Thr 130 135 140 Glu Val Val Lys Arg Cys Pro Asn His Glu Leu Ser Arg Glu Phe Asn 145 150 155 160 Glu Gly Gln Ile Ala Pro Pro Ser His Leu Ile Arg Val Glu Gly Asn 165 170 175 Ser His Ala Gln Tyr Val Glu Asp Pro Ile Thr Gly Arg Gln Ser Val 180 185 190 Leu Val Pro Tyr Glu Pro Pro Gln Val Gly Thr Glu Phe Thr Thr Val 195 200 205 Leu Tyr Asn Phe Met Cys Asn Ser Ser Cys Val Gly Gly Met Asn Arg 210 215 220 Arg Pro Ile Leu Ile Ile Val Thr Leu Glu Thr Arg Asp Gly Gln Val 225 230 235 240 Leu Gly Arg Arg Cys Phe Glu Ala Arg Ile Cys Ala Cys Pro Gly Arg 245 250 255 Asp Arg Lys Ala Asp Glu Asp Ser Ile Arg Lys Gln Gln Val Ser Asp 260 265 270 Ser Thr Lys Asn Gly Asp Gly Thr Lys Arg Pro Phe Arg Gln Asn Thr 275 280 285 His Gly Ile Gln Met Thr Ser Ile Lys Lys Arg Arg Ser Pro Asp Asp 290 295 300 Glu Leu Leu Tyr Leu Pro Val Arg Gly Arg Glu Thr Tyr Glu Met Leu 305 310 315 320 Leu Lys Ile Lys Glu Ser Leu Glu Leu Met Gln Tyr Leu Pro Gln His 325 330 335 Thr Ile Glu Thr Tyr Arg Gln Gln Gln Gln Gln Gln His Gln His Leu 340 345 350 Leu Gln Lys Gln Thr Ser Ile Gln Ser Pro Ser Ser Tyr Gly Asn Ser 355 360 365 Ser Pro Pro Leu Asn Lys Met Asn Ser Met Asn Lys Leu Pro Ser Val 370 375 380 Ser Gln Leu Ile Asn Pro Gln Gln Arg Asn Ala Leu Thr Pro Thr Thr 385 390 395 400 Ile Pro Asp Gly Met Gly Ala Asn Ile Pro Met Met Gly Thr His Met 405 410 415 Pro Met Ala Gly Asp Met Asn Gly Leu Ser Pro Thr Gln Ala Leu Pro 420 425 430 Pro Pro Leu Ser Met Pro Ser Thr Ser His Cys Thr Pro Pro Pro Pro 435 440 445 Tyr Pro Thr Asp Cys Ser Ile Val Ser Phe Leu Ala Arg Leu Gly Cys 450 455 460 Ser Ser Cys Leu Asp Tyr Phe Thr Thr Gln Gly Leu Thr Thr Ile Tyr 465 470 475 480 Gln Ile Glu His Tyr Ser Met Asp Asp Leu Ala Ser Leu Lys Ile Pro 485 490 495 Glu Gln Phe Arg His Ala Ile Trp Lys Gly Ile Leu Asp His Arg Gln 500 505 510 Leu His Glu Phe Ser Ser Pro Ser His Leu Leu Arg Thr Pro Ser Ser 515 520 525 Ala Ser Thr Val Ser Val Gly Ser Ser Glu Thr Arg Gly Glu Arg Val 530 535 540 Ile Asp Ala Val Arg Phe Thr Leu Arg Gln Thr Ile Ser Phe Pro Pro 545 550 555 560 Arg Asp Glu Trp Asn Asp Phe Asn Phe Asp Met Asp Ala Arg Arg Asn 565 570 575 Lys Gln Gln Arg Ile Lys Glu Glu Gly Glu 580 585 <210> 3 <211> 1761 <212> DNA <213> Homo sapiens <400> 3 atgttgtacc tggaaaacaa tgcccagact caatttagtg agccacagta cacgaacctg 60 gggctcctga acagcatgga ccagcagatt cagaacggct cctcgtccac cagtccctat 120 aacacagacc acgcgcagaa cagcgtcacg gcgccctcgc cctacgcaca gcccagctcc 180 accttcgatg ctctctctcc atcacccgcc atcccctcca acaccgacta cccaggcccg 240 cacagtttcg acgtgtcctt ccagcagtcg agcaccgcca agtcggccac ctggacgtat 300 tccactgaac tgaagaaact ctactgccaa attgcaaaga catgccccat ccagatcaag 360 gtgatgaccc cacctcctca gggagctgtt atccgcgcca tgcctgtcta caaaaaagct 420 gagcacgtca cggaggtggt gaagcggtgc cccaaccatg agctgagccg tgaattcaac 480 gagggacaga ttgcccctcc tagtcatttg attcgagtag aggggaacag ccatgcccag 540 tatgtagaag atcccatcac aggaagacag agtgtgctgg taccttatga gccaccccag 600 gttggcactg aattcacgac agtcttgtac aatttcatgt gtaacagcag ttgtgttgga 660 gggatgaacc gccgtccaat tttaatcatt gttactctgg aaaccagaga tgggcaagtc 720 ctgggccgac gctgctttga ggcccggatc tgtgcttgcc caggaagaga caggaaggcg 780 gatgaagata gcatcagaaa gcagcaagtt tcggacagta caaagaacgg tgatggtacg 840 aagcgcccgt ttcgtcagaa cacacatggt atccagatga catccatcaa gaaacgaaga 900 tccccagatg atgaactgtt atacttacca gtgaggggcc gtgagactta tgaaatgctg 960 ttgaagatca aagagtccct ggaactcatg cagtaccttc ctcagcacac aattgaaacg 1020 tacaggcaac agcaacagca gcagcaccag cacttacttc agaaacagac ctcaatacag 1080 tctccatctt catatggtaa cagctcccca cctctgaaca aaatgaacag catgaacaag 1140 ctgccttctg tgagccagct tatcaaccct cagcagcgca acgccctcac tcctacaacc 1200 attcctgatg gcatgggagc caacattccc atgatgggca cccacatgcc aatggctgga 1260 gacatgaatg gactcagccc cacccaggca ctccctcccc cactctccat gccatccacc 1320 tcccactgca cacccccacc tccgtatccc acagattgca gcattgtcag tttcttagcg 1380 aggttgggct gttcatcatg tctggactat ttcacgaccc aggggctgac caccatctat 1440 cagattgagc attactccat ggatgatctg gcaagtctga aaatccctga gcaatttcga 1500 catgcgatct ggaagggcat cctggaccac cggcagctcc acgaattctc ctccccttct 1560 catctcctgc ggaccccaag cagtgcctct acagtcagtg tgggctccag tgagacccgg 1620 ggtgagcgtg ttattgatgc tgtgcgattc accctccgcc agaccatctc tttcccaccc 1680 cgagatgagt ggaatgactt caactttgac atggatgctc gccgcaataa gcaacagcgc 1740 atcaaagagg agggggagtg a 1761

Claims

A gene of SEQ ID NO: 1 encoding ΔNp63α that migrates from the nucleus to the cytoplasm by contact of a potential anticancer agent in epithelial cell derived cancer cells.

A protein of ΔNp63α SEQ ID NO: 2 that migrates from the nucleus to the cytoplasm by contact of a potential anticancer agent in epithelial cell derived cancer cells.

A recombinant vector comprising a cassette comprising a ΔNp63α cDNA sequence of SEQ ID NO: 3 that migrates from the nucleus to the cytoplasm by administration of a potential anticancer agent in epithelial cell-derived cancer cells and a reporter gene for confirming expression of the sequence.

Cancer cells transformed with the recombinant vector according to claim 3.

A method for screening an anticancer agent, wherein the ΔNp63α protein moves from the nucleus to the cytoplasm by administration of a potential anticancer agent in epithelial cell-derived cancer cells.

The method of claim 5, wherein the cancer cells are transformed with a recombinant vector comprising a ΔNp63α gene and a reporter gene capable of identifying the cancer cell screening method.

Cloning the ΔNp63α gene and the reporter gene capable of identifying the same into a vector;

Transforming the cloned vector into epithelial cell-derived cancer cells and expressing the cloned vector;

Contacting the latent substance with the cancer cell; And

A method for screening an anticancer agent, characterized in that the position of the ΔNp63α gene includes the movement from the nucleus to the cytoplasm.

A recombinant vector comprising a ΔNp63α gene and a reporter gene capable of identifying the same;

Cancer cells transformed with the recombinant vector;

The anticancer drug screening kit comprising a means for contacting the cancer cell with a potential substance to confirm the transfer of the ΔNp63α gene from the nucleus to the cytoplasm.