KR20070048140A - 온코세르카 볼불러스의 천연 생성물의 항원보강성 및 면역강화 특성 - Google Patents

온코세르카 볼불러스의 천연 생성물의 항원보강성 및 면역강화 특성 Download PDF

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KR20070048140A
KR20070048140A KR20067027886A KR20067027886A KR20070048140A KR 20070048140 A KR20070048140 A KR 20070048140A KR 20067027886 A KR20067027886 A KR 20067027886A KR 20067027886 A KR20067027886 A KR 20067027886A KR 20070048140 A KR20070048140 A KR 20070048140A
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sequence
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composition
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앵거스 제이. 맥도날드
사라 러스티그맨
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더 뉴욕 블러드 센터, 인코포레이티드
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    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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    • C12N2770/20011Coronaviridae
    • C12N2770/20034Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR20067027886A 2004-06-15 2005-06-15 온코세르카 볼불러스의 천연 생성물의 항원보강성 및 면역강화 특성 Withdrawn KR20070048140A (ko)

Applications Claiming Priority (2)

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US58025404P 2004-06-15 2004-06-15
US60/580,254 2004-06-15

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KR20070048140A true KR20070048140A (ko) 2007-05-08

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KR20067027886A Withdrawn KR20070048140A (ko) 2004-06-15 2005-06-15 온코세르카 볼불러스의 천연 생성물의 항원보강성 및 면역강화 특성

Country Status (13)

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US (3) US7700120B2 (https=)
EP (1) EP1768696B1 (https=)
JP (1) JP4825797B2 (https=)
KR (1) KR20070048140A (https=)
CN (1) CN101151049A (https=)
AU (1) AU2005254087B2 (https=)
BR (1) BRPI0512173A (https=)
CA (1) CA2570218C (https=)
ES (1) ES2549669T3 (https=)
IL (1) IL180079A (https=)
NZ (1) NZ552583A (https=)
WO (1) WO2005122739A2 (https=)
ZA (1) ZA200700457B (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4683740B2 (ja) * 2001-02-15 2011-05-18 明治乳業株式会社 炎症に伴う症状の軽減剤
NZ552583A (en) * 2004-06-15 2009-09-25 New York Blood Ct Inc Adjuvancy and immune potentiating properties of natural products of onchocerca volvulus
US9592287B2 (en) 2009-10-09 2017-03-14 New York Blood Center, Inc. Immunopotentiator-linked oligomeric influenza immunogenic compositions
CN103554241B (zh) * 2013-10-25 2015-04-15 中国人民解放军军事医学科学院微生物流行病研究所 一种具有免疫调节活性的重组蛋白asppr及应用
IL260021B (en) 2015-12-14 2022-09-01 Macrogenics Inc Bispecific molecules that are immunoreactive for pd1 and ctla4 and methods for using them
JP6256460B2 (ja) 2015-12-28 2018-01-10 日亜化学工業株式会社 チオガレート系蛍光体の製造方法
US20190142916A1 (en) 2016-04-01 2019-05-16 New York Blood Center, Inc. Biomarkers and immunogenic compositions for filarial parasites
JP6561976B2 (ja) 2016-12-02 2019-08-21 日亜化学工業株式会社 チオガレート系蛍光体の製造方法、発光装置の製造方法、チオガレート系蛍光体及び発光装置

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4370265A (en) * 1974-10-22 1983-01-25 Agence Nationale De Valorisation Water soluble agents effective as immunological adjuvants for stimulating in the host the immune response to various antigens and compositions, notably vaccines containing said water soluble agents
US5169840A (en) 1991-03-27 1992-12-08 Nobipols Forskningsstiftelse Diequatorially bound β-1, 4 polyuronates and use of same for cytokine stimulation
US20020102273A1 (en) * 1995-08-08 2002-08-01 Robert B. Grieve Use of alphavirus expression vectors to produce parasite anitgens
US5789194A (en) * 1995-05-23 1998-08-04 Heska Corporation Parasitic helminth venom allergen antigen 5-like genes and proteins
US6682746B2 (en) 1995-09-21 2004-01-27 Kristina J. Hennessy Adjuvanted vaccine which is substantially free of non-host albumin
WO1998048832A1 (en) 1997-05-01 1998-11-05 Protechtion Unlimited, Inc. Nerve growth factor as a vaccine adjuvant
FR2775601B1 (fr) 1998-03-03 2001-09-21 Merial Sas Vaccins vivants recombines et adjuves
NZ508013A (en) 1998-05-07 2003-08-29 Corixa Corp Adjuvant composition for use with an antigen in a vaccine composition
FR2790959B1 (fr) * 1999-03-15 2003-06-27 Pf Medicament Utilisation de fractions membranaires bacteriennes a effet adjuvant, leurs procedes de preparation et composition pharmaceutique les contenant
ATE397942T1 (de) 1999-03-26 2008-07-15 Vical Inc Adjuvanszusammensetzungen zur erhöhung der immunantwort bezüglich polynukleotid-basierenden impfstoffen
US6649170B1 (en) 1999-05-12 2003-11-18 Statens Serum Institut Adjuvant combinations for immunization composition and vaccines
US6635261B2 (en) 1999-07-13 2003-10-21 Wyeth Holdings Corporation Adjuvant and vaccine compositions containing monophosphoryl lipid A
US6537552B1 (en) 1999-10-19 2003-03-25 Iowa State University Research Foundation Vaccine adjuvant
US6723322B1 (en) * 2000-04-03 2004-04-20 New York Blood Center, Inc. Angiogenic Onchocerca volvulus proteins and uses thereof
JP2004529906A (ja) * 2001-03-19 2004-09-30 イオマイ コーポレイシヨン 経皮的免疫賦活
US6676958B2 (en) 2001-06-19 2004-01-13 Advanced Bioadjuvants, Llc Adjuvant composition for mucosal and injection delivered vaccines
GB0123756D0 (en) * 2001-10-03 2001-11-21 King S College London A novel chaperone-type of adjuvant for vaccination - Basic 1
NZ552583A (en) 2004-06-15 2009-09-25 New York Blood Ct Inc Adjuvancy and immune potentiating properties of natural products of onchocerca volvulus

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Publication number Publication date
US9017699B2 (en) 2015-04-28
IL180079A (en) 2013-12-31
EP1768696A4 (en) 2008-02-13
IL180079A0 (en) 2007-05-15
US9255140B2 (en) 2016-02-09
WO2005122739A3 (en) 2006-08-10
US20100266634A1 (en) 2010-10-21
CN101151049A (zh) 2008-03-26
AU2005254087B2 (en) 2010-12-09
CA2570218A1 (en) 2005-12-29
WO2005122739A2 (en) 2005-12-29
JP4825797B2 (ja) 2011-11-30
JP2008502695A (ja) 2008-01-31
CA2570218C (en) 2015-11-10
US20090191229A1 (en) 2009-07-30
ES2549669T3 (es) 2015-10-30
AU2005254087A1 (en) 2005-12-29
EP1768696B1 (en) 2015-08-12
US7700120B2 (en) 2010-04-20
US20060039921A1 (en) 2006-02-23
EP1768696A2 (en) 2007-04-04
NZ552583A (en) 2009-09-25
ZA200700457B (en) 2008-08-27
BRPI0512173A (pt) 2008-02-12

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