KR20070046116A - 고지질혈증 및 당뇨병 치료용 ppar 리간드〔퍼옥시좀증식체-활성화 수용체〕로서 사용된2-〔-3-'2-(페닐)-옥사졸-4-일메톡시메틸-사이클로헥실메톡시〕-프로피온산 유도체 - Google Patents

고지질혈증 및 당뇨병 치료용 ppar 리간드〔퍼옥시좀증식체-활성화 수용체〕로서 사용된2-〔-3-'2-(페닐)-옥사졸-4-일메톡시메틸-사이클로헥실메톡시〕-프로피온산 유도체 Download PDF

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Publication number
KR20070046116A
KR20070046116A KR1020077003579A KR20077003579A KR20070046116A KR 20070046116 A KR20070046116 A KR 20070046116A KR 1020077003579 A KR1020077003579 A KR 1020077003579A KR 20077003579 A KR20077003579 A KR 20077003579A KR 20070046116 A KR20070046116 A KR 20070046116A
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KR
South Korea
Prior art keywords
formula
compound
alkyl
acid
ylmethoxymethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1020077003579A
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English (en)
Korean (ko)
Inventor
하이너 글롬빅
크리슈티안 슈타퍼
오이겐 팔크
슈테파니 카일
한스-루드빅 쉐퍼
볼프강 벤들러
슈테파니 크닙스
Original Assignee
사노피-아벤티스 도이칠란트 게엠베하
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 사노피-아벤티스 도이칠란트 게엠베하 filed Critical 사노피-아벤티스 도이칠란트 게엠베하
Publication of KR20070046116A publication Critical patent/KR20070046116A/ko
Withdrawn legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • A61K31/4211,3-Oxazoles, e.g. pemoline, trimethadione
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
KR1020077003579A 2004-08-14 2005-07-30 고지질혈증 및 당뇨병 치료용 ppar 리간드〔퍼옥시좀증식체-활성화 수용체〕로서 사용된2-〔-3-'2-(페닐)-옥사졸-4-일메톡시메틸-사이클로헥실메톡시〕-프로피온산 유도체 Withdrawn KR20070046116A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004039533A DE102004039533B4 (de) 2004-08-14 2004-08-14 Essigsäurederivate mit Cyclohexylmethoxy-Substituenten, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel
DE102004039533.0 2004-08-14

Publications (1)

Publication Number Publication Date
KR20070046116A true KR20070046116A (ko) 2007-05-02

Family

ID=35376939

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020077003579A Withdrawn KR20070046116A (ko) 2004-08-14 2005-07-30 고지질혈증 및 당뇨병 치료용 ppar 리간드〔퍼옥시좀증식체-활성화 수용체〕로서 사용된2-〔-3-'2-(페닐)-옥사졸-4-일메톡시메틸-사이클로헥실메톡시〕-프로피온산 유도체

Country Status (21)

Country Link
US (1) US7538131B2 (https=)
EP (1) EP1789402B1 (https=)
JP (1) JP2008509894A (https=)
KR (1) KR20070046116A (https=)
CN (1) CN101014579A (https=)
AR (1) AR050121A1 (https=)
AT (1) ATE449086T1 (https=)
AU (1) AU2005274495A1 (https=)
BR (1) BRPI0514360A (https=)
CA (1) CA2576584A1 (https=)
DE (2) DE102004039533B4 (https=)
DK (1) DK1789402T3 (https=)
ES (1) ES2335513T3 (https=)
IL (1) IL181011A0 (https=)
MX (1) MX2007000846A (https=)
PA (1) PA8641601A1 (https=)
PE (1) PE20060643A1 (https=)
PT (1) PT1789402E (https=)
TW (1) TW200621733A (https=)
UY (1) UY29064A1 (https=)
WO (1) WO2006018118A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009509988A (ja) 2005-09-29 2009-03-12 サノフィ−アベンティス フェニル−及びピリジニル−1,2,4−オキサジアゾロン誘導体、その製造方法、及び医薬品としてのその使用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20040199A2 (en) * 2001-08-31 2005-04-30 Aventis Pharma Deutschland Gmbh Diaryl cycloalkyl derivatives, method for producing the same and the use thereof as ppar activators
DE10308355A1 (de) * 2003-02-27 2004-12-23 Aventis Pharma Deutschland Gmbh Aryl-cycloalkyl substituierte Alkansäurederivate, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel

Also Published As

Publication number Publication date
MX2007000846A (es) 2007-04-17
WO2006018118A1 (de) 2006-02-23
AU2005274495A1 (en) 2006-02-23
ES2335513T3 (es) 2010-03-29
ATE449086T1 (de) 2009-12-15
UY29064A1 (es) 2006-02-24
US7538131B2 (en) 2009-05-26
DE102004039533B4 (de) 2006-09-28
BRPI0514360A (pt) 2008-07-15
PT1789402E (pt) 2010-02-01
WO2006018118A8 (de) 2006-05-18
DE502005008552D1 (de) 2009-12-31
US20070197612A1 (en) 2007-08-23
CA2576584A1 (en) 2006-02-23
DE102004039533A1 (de) 2006-03-02
DK1789402T3 (da) 2010-03-22
TW200621733A (en) 2006-07-01
CN101014579A (zh) 2007-08-08
JP2008509894A (ja) 2008-04-03
AR050121A1 (es) 2006-09-27
PE20060643A1 (es) 2006-07-26
IL181011A0 (en) 2007-07-04
EP1789402A1 (de) 2007-05-30
PA8641601A1 (es) 2006-03-24
EP1789402B1 (de) 2009-11-18

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Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20070214

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid