KR20050118321A - Integrated filling system and multi-chamber bag including the same - Google Patents

Abstract

The present invention relates to an integrated filling system and a multi-chambered container having the same, and more particularly, to a filling system mounted in a multi-chambered container including a plurality of chambers in which a plurality of drugs are isolated and stored, wherein each of the drugs A plurality of filling channels for guiding the respective into said chamber; And a support for supporting the plurality of filling channels at a predetermined distance from each other.

The invention also relates to a multi-chambered vessel having the filling system described above.

Description

Integrated filling system and multi-chamber bag including the same}

The present invention relates to a system used for filling a drug and to a multi-chamber container having the same, and more particularly, to an integrated filling system for guiding a plurality of drugs to be stored in isolation into each corresponding chamber, and It relates to one multi-chamber container.

Generally, when injecting a patient with injection, one or more drugs of antibiotics, anticancer drugs, glucose sap, amino acid sap, lipid sap and osmotic sap may be administered. However, when the drugs are mixed and stored before administration to a patient, the drug stability is inferior due to drug interactions, or is deteriorated when stored for a long time. For example, amino acids and glucose can be mixed to make a non-oral solution for administering intravenous injections to a patient, but when mixed and stored in one solution they are often altered due to drug interactions, resulting in poor formulation stability.

Therefore, many drugs cannot be mixed in advance, but rather, each drug is stored in a separate container and then mixed before use. In this case, however, when the two or more drugs are mixed, the drug may be contaminated during the mixing process due to the carelessness of the person mixing the drugs. This may be a concern. In addition, there was a problem that takes time and effort to carefully mix the drug.

In order to solve this problem, a multi-chamber container including a plurality of chambers in which a plurality of drugs are isolated and stored is used.

The multi-chambered container solves the problem of mixing drugs stored in separate containers, but includes a plurality of filling ports installed at both ends of the container to fill the drug in each chamber, which is folded or However, there was a problem in that it is not possible to quickly fill drugs in a plurality of chambers without a specially designed filling device for filling the chambers on both sides.

In the prior art to solve this problem, Korean Patent No. 299630 discloses a multi-chamber container 10 in which filling ports 21 and 22 are located on the same outer surface of the container in a container having two or more chambers. . In the case of the multi-chamber container 10 described above The filling operation is easy, but the filling port mounting process is complicated because each filling port 21, 22 for each of the chambers 11, 12 has to be manufactured and then separately mounted at various spaced positions on the multi-chamber container 10. Do.

Fill channel closure is also complicated, as each fill channel must be capped and sealed.

Furthermore, two joining portions 41 formed at each of the filling ports 21 and 22 and the discharge port 31 are formed at an angle of substantially 90 °, so that the process of closely contacting the container 10 is very difficult. , A gap occurs in the junction part 41 and the stored drug is very likely to be contaminated or leaked.

Therefore, an attempt to improve the problem of the filling port raised in the conventional multi-chamber container has been steadily raised, and in the multi-chamber container made of PVC film, there is a problem in that phthalate plasticizer or stabilizer, which is an environmental hormone, is eluted. The necessity to do so is urgently required.

The object of the present invention for solving the above problems of the prior art, while the filling operation of the drug can be made conveniently and quickly, easy to install and seal the container, minimizing the risk of contamination and leakage of the drug stored in the container It is to provide a filling system and a multi-chamber container having the same.

In order to achieve the above object, the present invention provides a filling system mounted in a multi-chamber container including a plurality of chambers in which a plurality of drugs are isolated and stored, the plurality of drugs for guiding each of the drugs into each of the chambers; Filling channels; And a support for supporting the plurality of filling channels at a predetermined distance from each other.

The filling system further comprises sealing means for sealing the plurality of filling channels, wherein the sealing means can be composed of sealing means capable of sealing each or a plurality of filling channels.

A body formed to cover the plurality of filling channels when the sealing means is constituted by a sealing means capable of sealing integrally; And a plurality of channel accommodating parts formed in the body and configured to seal one end portion of each of the filling channels by sealing. At this time, the filling channel may further include a packing for sealing each filling channel.

In addition, the sealing means may be composed of a plurality of protrusions capable of sealing while sealing the filling channel instead of the channel receiving portion.

In the filling system, the support may further include at least one contamination bump formed to protrude between adjacent filling channels.

Meanwhile, the present invention provides a multi-chamber container for separating and storing a plurality of different drugs, the plurality of chambers each of which stores the plurality of drugs; A peelable seal formed between the plurality of chambers, the peelable seal being opened by external pressure to mix and store the drugs separately stored in the plurality of chambers; And the filling system.

In this case, the multi-chambered container has an extension at least one of the plurality of chambers extending along the edge of the container to the filling system.

Drugs stored in the respective chambers are parenteral administration drugs such as antibiotics, anticancer agents, in addition to glucose sap, amino acid sap, lipid sap and osmotic sap used as a sap.

On the other hand, the material of the multi-chamber container of the present invention should not elute plasticizers or stabilizers, have no water vapor permeability, be capable of autoclaving under pressure, and satisfy the conditions of the synthetic material of the chemical liquid container which should be transparent for foreign material inspection. do. In addition, the filling system and the multi-chamber container may be manufactured using the same or similar materials, preferably a multi-layer film made of a polyolefin-based synthetic resin material that does not elute plasticizers or stabilizers.

Hereinafter, the multi-chamber container of the present invention and a filling system mounted thereon will be described in detail with reference to the accompanying drawings.

Figure 2 is a front sectional view showing one embodiment of a multi-chamber container according to the present invention, Figure 3a is an exploded perspective view showing an embodiment of the filling system shown in Figure 2, Figure 3b is a view of the filling system shown in Figure 2 An exploded perspective view showing another embodiment.

As shown in FIG. 2, the multi-chamber container 100 according to the present invention includes a first chamber 111 positioned at an upper side and a second chamber 113 positioned at a right side of the first chamber 111. The third chamber 115 positioned below the first and second chambers 111 and 113 and the filling chamber in fluid communication with the first to third chambers 111, 113 and 115 mounted at an upper side of the container 100. And a discharge port 300 mounted at the bottom of the vessel 100 and in fluid communication with the third chamber 115.

The first to third chambers 111, 113, and 115 are formed by closely contacting two container films having flexibility, and heating the upper portion 101, the lower portion 103, the left and right side portions 105 and 107, It is isolated and partitioned from the outside by two permanent seals 123 and a peelable seal 121. The first to third chambers 111, 113, and 115 have different drugs guided through the filling system 200, for example, antibiotics (prepenem, etc.), anticancer agents (cisplatin, alkylsiloxanes, etc.) and glucose. Sap, amino acid sap, electrolyte sap, lipid sap, osmotic sap and the like. In this embodiment, an antibiotic or an anticancer agent is stored in the first chamber 111, an amino acid solution or a lipid sap is stored in the second chamber 113, and a glucose solution is stored in the third chamber 115. On the other hand, in this embodiment, one side of the third chamber 115 is formed with an extension portion 117 extending along the edge of the container, in the illustrated example, along the left side portion 105 toward the filling system 200. Here, the container film may be a multi-layer film formed by stacking an inner layer in contact with the drug, an outer layer exposed to the atmosphere, and at least one intermediate layer located between the inner layer and the outer layer. In this case, the inner layer is made of a polyolefin resin material considering the adhesiveness and the stability of the drug, the middle layer is made of a polyolefin resin material considering the flexibility and moisture and / or gas barrier properties, the outer layer is equipment application and high temperature (About 121 ° C) It may be made of a polyolefin-based resin material in consideration of heat resistance for sterilization.

The peelable seal 121 is formed between the third chamber 115 and the first and second chambers 111 and 113, and the predetermined or more external pressure applied to any one of the chambers 111, 113 and 115. Opened by to allow the drug stored in the first and second chambers 111 and 113 to be mixed with the drug stored in the third chamber 115.

The permanent seal 123 is a part permanently sealed together with the upper end 101, the lower end 103, and the left and right side parts 105 and 107 and is not opened by external pressure.

In addition, the hook portion 131 is formed to be positioned substantially in line with the discharge port 300 of the upper portion 101, the hook portion 131 is administered to the human body the drug stored in the chamber (111, 113, 115) In this case, a hook or the like of a suspending device for maintaining the container 100 at a predetermined height can be hung.

Filling system 200, referring to Figure 3a, a plurality of filling channels 210 formed of a hollow (hollow) open at both ends, the support 220 is fixed in contact with the upper end 101 of the container, adjacent filling channels The contamination preventing jaw 230 formed on the support 220 so as to be located between the fields 210, a plurality of packings 240 inserted into each filling channel 210 and sealing means fitted to the filling channel 210 ( 250).

One end (lower) of each filling channel 210 is formed to protrude into a predetermined chamber, and guides a drug provided from an external filling device into the chamber. The filling channel 210 is supported by the support 220 to maintain a predetermined interval, and the plurality of filling channels 210 and the support 220 may be integrally formed. In addition, the sidewall surface of the support body 220 directly contacting the film for the container may be formed in an arc shape having a predetermined curvature as shown in FIG. 3A, or may be formed in a wave shape as shown in FIG. 3B. Here, both ends of the support 220 is formed in a wedge shape to form a gentle inclination with the surrounding container portion is closely fixed to the multi-chamber container 100, and thus the multi-chamber container of the present invention is The airtightness can be improved compared to the chamber container.

The contamination prevention jaw 230 prevents the drug from splashing toward the other filling channel 210 when the drug is filled.

The packing 240 seals the filling channel 210 so that the contaminants existing in the sealing means 250 or the outside through the filling channel 210 by the post-filling process are stored in the chambers 111, 113, and 115. To prevent from entering.

The sealing means 250 may include a body 251 formed in an outer shape substantially the same as that of the support 220, and a plurality of channel receiving parts 253 having a size to which the protruding upper portion of each of the filling channels 210 fits. In addition, the contamination prevention jaw 230 is provided with a plurality of slots 255. The sealing means 250 simultaneously covers the plurality of filling channels 210 and blocks them from external pollutants, so that contaminants are introduced into the chambers 111, 113, and 115 through the filling channels 210 during distribution of the product. To prevent them.

It will be apparent to those skilled in the art that the filling system of the present invention as described above and the multi-chambered container having the same are not limited to the above-described embodiments, and may be variously modified, changed or replaced as shown in FIGS. 4 to 6. will be.

Other embodiments of the present invention are shown in the accompanying Figures 4 to 6, the same or similar parts as in the above-described embodiment will be omitted and the same reference numerals are used.

4 is a front sectional view showing another embodiment of a multi-chambered container according to the present invention. Referring to FIG. 4, the multi-chamber container 100 according to the present invention includes first and second chambers 111a and 113a in which different drugs are to be stored, and drugs supplied from the outside in the first and second chambers 111a, A filling system 200a for guiding into 113a), and a discharge port 300. In this case, the filling channels 210a of the filling system 200a are two, and the drugs stored in the respective chambers 111a and 113a through the filling system 200a are mixed by the opening of the peelable seal 121. .

5 is a front sectional view showing yet another embodiment of a multi-chambered container according to the present invention. Referring to FIG. 5, the multi-chamber container 100 according to the present invention is first and second chambers 111b and 113b partitioned by the permanent seal 123 and the first and second peelable seals 121b. And a filling system 200b and a third chamber 115b mounted in fluid communication with the third chamber 115b separated from the second chambers 111b and 113b, the first and second chambers 111b and 113b. And a fill / discharge port 300b mounted to communicate therewith.

Unlike in the above-described embodiments, the peelable seal 121b in this embodiment is formed such that both ends thereof contact the left and right side portions 105 and 107, and the third chamber 115b has a filling system 200b. No extension extending to the side is formed. In addition, the filling / discharging port 300b guides the drug provided from the outside into the third chamber 115b, and when the drug is injected into the patient, the mixed drug is discharged by the opening of the peelable seal 121b. Accordingly, the filling system 200b has two filling channels 210b to direct the drug only to the first and second chambers 111b and 113b.

6 is a front sectional view showing yet another embodiment of a multi-chambered container according to the present invention. Referring to FIG. 6, the multi-chambered container 100 according to the present invention includes the first to third chambers 111c, 113c, and 115c and the first to third chambers 111c, 113c, and 115c which are positioned in parallel with each other. It may include a filling system 200c mounted on the left side portion 105 side in fluid communication, two peelable seals 121c positioned between the adjacent chambers, and a discharge port 300.

Moreover, in the above-described embodiments, only the case where the upper portion of the filling channel 210 protrudes out of the support 220 is illustrated and described, but in another embodiment of the present invention, the protruding portion of the filling channel 210 A filling system can be formed without a top, in which case the sealing means 250 can be formed with a protrusion for fitting the filling channel 210 to seal the filling channel 210 instead of the channel receiving portion 253. .

As described above, the present invention is provided with a plurality of filling channels for guiding the drugs to the plurality of chambers in one filling system, so that the filling operation of the drugs can be easily performed.

In addition, since the filling system can be manufactured and mounted at a time without having to manufacture and fill each filling port as many chambers as possible, the manufacturing and mounting process of the filling system can be easily performed.

In addition, the filling channel sealing operation can be easily performed by using a sealing means capable of simultaneously covering and sealing a plurality of filling channels. On the other hand, the present invention is because the filling system is formed so that the junction between the filling system and the container is gently inclined, the possibility of gaps in the junction is minimized, excellent airtightness of the container, thereby minimizing the possibility of drug contamination and leakage can do.

Figure 1a is a front view showing a multi-chamber container of the prior art Republic of Korea Patent No. 299630,

1B is a cross-sectional view taken along the line II ′ of FIG. 1A,

Figure 2 is a front cross-sectional view showing an embodiment of a multi-chamber container according to the present invention,

Figure 3a is an exploded perspective view showing an embodiment of the filling system shown in FIG.

3B is an exploded perspective view showing another embodiment of the filling system shown in FIG. 2, FIG.

4 is a front sectional view showing another embodiment of a multi-chambered container according to the present invention;

5 is a front sectional view showing yet another embodiment of a multi-chambered container according to the present invention; and

6 is a front sectional view showing yet another embodiment of a multi-chambered container according to the present invention.

<Explanation of symbols for the main parts of the drawings>

10 conventional multi-chamber container, 11 first chamber, 12 second chamber,

21: first filling port, 22: second filling port, 31: discharge port,

100: multi-chamber container, 101: upper part, 103: lower part,

105: left side portion, 107: right side portion,

111: first chamber, 113: second chamber, 115: third chamber, 117: extension

121: peelable sealing part, 123: permanent sealing part, 131: hook part,

200: filling system, 210: filling channel, 220: support,

230: contamination prevention jaw, 240: packing, 250: sealing means,

251: body, 253: channel receiving portion, 255: slot

300: discharge port

Claims (15)

A filling system mounted in a multi-chambered container comprising a plurality of chambers in which a plurality of drugs are isolated and stored, A plurality of filling channels for guiding each drug into each said chamber; And And a support for supporting the plurality of filling channels at a predetermined distance from each other. 2. The filling system of claim 1, further comprising a plurality of packings for respectively sealing said plurality of filling channels. 3. The filling system of claim 1 or 2, further comprising sealing means for sealing said plurality of filling channels. 4. The apparatus of claim 3, wherein the sealing means comprises: a body formed to cover the plurality of filling channels; And a plurality of channel receptacles formed in the body and configured such that one end of each of the filling channels is fitted and sealed. 4. The apparatus of claim 3, wherein the sealing means comprises: a body formed to cover the plurality of filling channels; And a plurality of protrusions protruding from the body and fitted into the filling channels to seal the filling channels. 3. The filling system of claim 1 or 2, further comprising at least one contamination bump protruding between adjacent adjacent filling channels. A container for separating and storing a plurality of different drugs, A plurality of chambers each storing the plurality of drugs; A peelable seal formed between the plurality of chambers, the peelable seal being opened by external pressure to mix and store the drugs separately stored in the plurality of chambers; And And a filling system comprising a plurality of filling channels for guiding each said drug into each said chamber, and a support for supporting said plurality of filling channels at a predetermined distance from each other. 8. The multi-chambered container of claim 7, wherein at least one of the plurality of chambers has an extension extending along the edge of the container to the filling system. 8. The multi-chambered container of claim 7, wherein the drug stored in the chamber is any one of antibiotics, anticancer agents, glucose sap, amino acid sap, lipid sap and osmotic sap. 8. The multi-chambered container of claim 7, wherein the filling system further comprises at least one contamination barrier formed to protrude between adjacent filling channels. The multi-chambered container according to any one of claims 7 to 10, wherein the material of the container is a multilayer film made of a polyolefin-based synthetic resin material. 11. The multi-chambered container of any of claims 7 to 10, wherein the filling system further comprises a plurality of packings for respectively sealing the plurality of filling channels. 11. The multi-chambered container of any of claims 7 to 10, wherein the filling system further comprises sealing means for sealing the plurality of filling channels. 14. The apparatus of claim 13, wherein the sealing means comprises: a body formed to cover the plurality of filling channels; And a plurality of channel receptacles formed in the body and configured to fit and seal one end of each of the filling channels. 14. The apparatus of claim 13, wherein the sealing means comprises: a body formed to cover the plurality of filling channels; And a plurality of protrusions protruding from the body and fitted into the filling channels to seal the filling channels.