KR20050041807A - The oral product of the solidity which is stabilized a whitening ingredient - Google Patents

Abstract

The present invention relates to a solid tooth whitening agent which contains a peroxide as a tooth whitening agent and stabilizes a whitening component. Specifically, the raw materials are mixed in a liquid state, and then thinly coated on a release liner, dried and a dried semi-finished product is manufactured by using an extrusion method. The raw material is directly injected into an extruder and then mixed in an extruder. The present invention relates to a method of manufacturing a solid tooth whitening agent by extrusion, or to a method of manufacturing a solid tooth whitening agent by putting a prepared semi-finished product in a molded state into a molded mold.

Unlike the tooth whitening agent developed in the solid of the present invention, the tooth whitening agent is more stabilized, and when applied to the tooth, it is characterized in that it can be easily applied to a desired tooth without falling or foreign body.

Description

Solid tooth whitening agent that stabilizes whitening ingredients {The oral product of the solidity which is stabilized a whitening ingredient}

The present invention aims to improve the whitening effect by improving the inconvenience of using the existing tooth whitening products and stabilizing the whitening component.

The present invention relates to a solid tooth whitening agent stabilized whitening component. More specifically, the present invention relates to a solid tooth whitening agent, which is conveniently prepared in a manner that is directly applied to the teeth by stabilizing the whitening component used in the teeth whitening.

In modern people, tooth coloring has increased due to changes in dietary habits, and interest in tooth whitening continues to increase, and many kinds of tooth whitening products have been released to meet these needs, but consumers' satisfaction has been greatly increased due to each problem. Not high.

In the traditional method of using toothpaste and toothbrush, even if the toothpaste contains a whitening agent that is effective, it is difficult to confirm the whitening effect in a short time by brushing with a contact time of 1 to 3 minutes.

Professional Whitening Gel products should be prepared with a tray suitable for the patient's tooth size and applied with a certain amount of high concentration of peroxide gel. Therefore, in terms of ease of use, cost, extra high concentration of peroxide gel and tray irritation of the gums It has problems in terms of safety.

EP 0511782A devised a coating for tooth whitening. This product has a viscosity of 30,000 ~ 50,000cps, so it can flow down after application or open mouth and dry the coating solution.

USP 5,824,291 contains a tooth whitening agent in the gum base and the tooth whitening component is released during chewing and reacts with the contaminants of the tooth to cause the tooth whitening effect, but the actual whitening component is dilute by saliva, so the actual effect is insignificant. .

Procter & Gamble (P & G) used a tooth whitening agent on a thin, transparent and flexible polyethylene strip instead of using a mouse tray in US Pat. Nos. 5,879,691, 5,891,453, 5,989,569 and WO 98/55044. -A tooth whitening delivery system is proposed that can be coated or applied directly to teeth or strips before use. The ease of use is improved by not using a mouse tray, and it is a big advantage that it is transparent and thin when worn, so that it does not interfere with daily life, but as can be seen from the examples, a gel having high viscosity (Viscosity) using a large amount of carbopol as a main gelling agent It is a wet type that pre-coated (Gel) thinly on a flexible polyethylene strip. When attaching it, it is easy to get high concentration of peroxide gel on the hands, tongue, and gums. It is a two-layered formulation of whitening ingredients and strips, and the peroxide stabilization technology in the formulation is not sufficiently secured, so that the whitening effect is reduced due to storage at high temperature or long term storage.

Colgate has formulated a Dow Corning 3179 Dilatant Compound called Dow Corning 3179 in United States Patent Nos. 5,310,563 and 5,639,445 to form an active ingredient, which is then lightly pressed to a tooth and easily peeled off. Presented. However, in this formulation, although the double layer but the active ingredient is encapsulated in the polymer, the stability of peroxide can be secured over time, but the active ingredient is difficult to escape from the delayed compound in a short time, so that a long contact time is required to obtain a whitening effect. This is a disadvantage required.

Lion Corporation proposes a sheet-like oral patch in Japanese Patent No. 10,017,448. This formulation consists of a tooth adhesion layer and a support layer, and the whitening agent may include kojic acid and its derivatives, ascorbic acid, ascorbic acid derivatives, urea peroxide, etc., but all of the whitening agents used have strong acidity. There is concern about the occurrence of irritation with pH in the oral cavity. In addition, there is a problem that it is difficult to obtain a patch having a small irritation and excellent whitening effect because of the whitening effect only in strong acidic properties of these whitening agents. This double layer patch is a whitening agent, and if the material is somewhat reactive, there is a disadvantage that the stability over time at high temperature may be deteriorated even if the release liner is stored.

Therefore, the present invention has been invented and devised a solid tooth whitening agent in a new formulation to improve the problems of the existing whitening products mentioned above.

The solid of the present invention refers to a range of hardness of 50 to 200, with no fluidity, so that it can be applied to a tooth in a holder.

The product of the present invention is composed of several kinds of polymers to maintain a constant hardness, the composite properties of the viscosity and elasticity of the polymer can be changed by various external conditions. Therefore, the hardness value suggested above is measured by Rheometer <Figure 2> of UDS-200 of Physica (USA), which stored 1hr in an incubator at 25 ℃, and put the finished product on the holder of Rheometer. This is the value from the moment the string connected to the adapter reaches the product until the product is completely cut.

Solid manufacturing methods can be classified into two types. First, raw materials such as tooth whitening component, polymer component stabilizing tooth whitening component, stabilizer, moisturizing component, solvent, etc. are mixed in the liquid phase, and then the liquid component is dried and dried. Method of manufacturing semi-finished products using the extruding method <Figure 3>. Second, the above-mentioned raw materials are added to the extruder and then directly mixed and extruded. There is a method of manufacturing.

In the structure of the extruder, the main body of the extruder is as shown in <Figure 3>. The rotation of the screw should be smoothly shifted by the gearless transmission in the range of 20 ~ 80rpm, and the screw is the most important part. The pushed semi-finished product should be accelerated at the same time as head direction and accelerated to increase the internal pressure evenly. In addition, it is necessary to extrude the semifinished product with uniform acceleration to a sufficient pressure so that sufficient molding can be achieved in the head and die.

The influx of semifinished products is also related to the shape of the feed-hopper that rests on the cylinder.

A and B are good for granular, but C is generally used for semi-finished products in the state required by the present invention. Equilibrium with the screw groove, the direction of rotation is downward, pushed well. The screw must be constructed so that the pressure on the semifinished product can be increased to push it in the head direction. This method includes a method of reducing the pitch of the screw groove as it goes to the tip, a constant pitch but a thinner groove toward the tip, and a constant pitch and a wider screw width toward the tip.

The present invention is to improve the manufacturing method as described above and to improve the whitening effect by stabilizing the whitening component.

In order to stabilize the whitening ingredients and to improve tooth whitening efficacy and usability, the present invention has been developed a solid tooth whitening agent and a method of manufacturing a new formulation.

Hereinafter, the present invention will be described in detail.

In the present invention, the tooth whitening components may include peroxides, chlorine bleaches, polyphosphates, Vit-E, enzymes such as dextranase, papain, and one or more components selected from them. Here, the peroxides include hydrogen peroxide, urea peroxide, sodium percarbonate, sodium perborate, calcium peroxide, sodium pyrophosphate, and the like. Polyphosphates include potassium pyrophosphate, sodium pyrophosphate, acidic pyrophosphate, sodium metaphosphate, sodium polyphosphate, potassium pyrophosphate and the like.

To stabilize the tooth whitening component, a polymer is used, and the polymer is cellulose gum, bentonite, carbopol, hydroxyethyl cellulose, hydroxymethyl cellulose, hydroxypropyl cellulose, polyvinyl alcohol, polyvinylacetate, pectin, starch, xanthan Gum, polyalkyl vinyl ether-maleic acid copolymer (PVM / MA copolymer, Gantrez AN 149, AN 139, S-97), polyacrylic acid, Poloxamer 407 (Pluronic), polyvinyl pyrrolidone-vinyl acetate copolymer (PVP / VA copolymer; Luviskol VA, Plasdone S PVP / VA), polyvinyl pyrrolidone (PVP, K-15-K-120), Polyquaterium-11 (Gafquat 755N), Polyquaterium-39 (Merquat plus 3330), hydroxypropyl Methylcellulose, gelatin, sodium alginate, polyvinylacetate, ethyl cellulose, polymethyl methacrylate, methacrylic acid copolymer, methacrylic copolymer, amino alkyl methacrylic It is listed ones, such as copolymers, cellulose acetate phthalate, polyethylene glycol and can be used at least one member selected from these components.

Stabilizers that can be added to stabilize the whitening ingredients in addition to the use of polymers include candelillan, beeswax, paraffin lead, lead, carbauna lead, ceresin, glycerin tri-2-ethylhexyl acid, liquid paraffin, and caprylic / Capric triglycerides, alkyl aryl sulfonates, alkylsulfonate salts, alkyl carboxylate salts, alkyl diphenyl oxide disulfonates, Span 20 (Sorbitan Monolaurate), Span 40 (Sorbitan Monopalmitate), Span 60 (Span 60, Sorbitan Monostearate), Span 80 (Span 80, Sorbitan Monooleate), Span 85 (Span 85, Sorbitan Trioleate), and TWEEN (POE sorbitan fatty acid ester). One or more selected components thereof can be used.

In addition, some polymers have poor flexibility and poor applicability. The moisturizing ingredients added to compensate for this include glycerin, sorbitol, propylene glycol, butylene glycol, ceramide, castor oil, and hydrogenated castor oil. The component selected above can be used.

Examples of the solvent include water and alcohol, and at least one selected from these may be used.

The amount of the raw material used may be used in combination of one or more of the above-described raw materials in the case of the whitening component, the use range of 1 to 15%, the polymer may be used in combination of one or more of the above-described raw materials, the use range of 25%, stabilizers can be used in combination of one or more of the above-described raw materials, the use range is 1 to 8%, the moisturizing component can be used to mix one or more of the above-described raw materials, the use range is 1 to 8% The solvent can mix and use 1 or more types of raw materials mentioned above, and the use range is 40 to 75%.

Solvent should be dried in order to solidify the liquid mixture made with the composition as above. When drying at high temperature, the stability of the whitening component is deteriorated. Therefore, the liquid mixture is applied thinly on the release liner for instant drying. The content of is dried to about 1 to 10% of the total weight.

In order to make the dried mixture have a uniform shape, the solid semi-finished product can be manufactured by removing the dried semi-finished product and extruding it by using an extrusion method (see Fig. 2). Solid teeth whitening agent can be manufactured by hardening in mold.

In addition, by varying the ratio of the solvent used by directly extruded the raw material presented above into the extruder without a separate mixing process. It is possible to manufacture a product similar to a solid lip stick by using only the extrusion method without a separate drying process.

Hereinafter, the configuration and effect of the present invention will be described in more detail with reference to Examples and Comparative Examples. The embodiments are provided to help understand the configuration of the present invention, and the present invention is not limited thereto.

Tooth whitening agents of Examples 1 to 5 and Comparative Examples 1 to 3 were prepared as described below.

EXAMPLE

As mentioned above, each manufacturing method was mixed with the above ingredients in a liquid phase, mixed thinly, and passed through a drying tunnel. .

Comparative Example 1

Toothpaste is prepared by blending 2% cellulose gum, 10% hydrogen peroxide (35% solution), 20% silica, 30% glycerin, and 100 to water.

Comparative Example 2

10% PVP, 10% hydrogen peroxide (35% solution), glycerin 5%, castor oil 4%, water: ethanol 1: 1 mixed pressure to 100 to form a white coating (simply white type).

Comparative Example 3

Carbopol 10%, hydrogen peroxide (35%) 10%, glycerin 5%, pH adjuster, water: ethanol 1: 1 mixture of 100 to make a gel, then apply a thin film (poly ethylene film) Make a whitening agent

[Evaluation of Teeth Whitening Effect]

The best way to evaluate the tooth whitening effect is to apply it to real teeth. Clinical subjects with reference to the Vita shade guide ¹⁾ went to Chu only with dark teeth than eight steps. The value changed from the initial color was recorded. In addition, the survey was conducted after use to evaluate the degree of whitening and feeling of use.

Each group was assigned to 20 male and female testers, and the usage and dosage of each group was used according to the characteristics of the product.

Examples 1 to 5: Apply to teeth three times a day.

Comparative Example 1: Toothbrush using a toothbrush three times a day.

Comparative Example 2: It is applied to the teeth twice a day.

Comparative example 3: It adheres to a tooth twice a day.

1) Vita Shade Guide: It is a tooth model that expresses the degree of change of tooth color in 16 steps. It is internationally recognized and used by doctors at universities, evaluation institutions, and dental hospitals to evaluate whitening effects.

2) Evaluate yourself with 5 points

1: no whitening effect, 2: yes. 3: weak whitening effect,

4: Fully recognized whitening effect, 5: Excellent whitening effect.

3) Clinical subjects were asked to evaluate the usability and convenience of the product in 5 points.

1: poor 2: slightly poor 3: moderate 4: good 5: excellent

The embodiment is superior in the tooth whitening effect than the comparative example because the tooth whitening component can be continuously maintained for a long time with the tooth without flowing down upon application to the tooth. Similarly, Comparative Example 3 (tooth-adhesive whitening agent) also showed an effect because it can be continuously attached to the teeth and deliver the whitening component. On the other hand, the whitening component of the toothpaste and tooth whitening coating formulation was continuously diluted by intraoral acupuncture after tooth application, and the actual effect was insignificant. Second, the oil component added as a stabilizer remained in the teeth to prevent dilution by saliva.

[Evaluation of Product Stability]

After pouch packaging the tooth whitening products prepared in Examples and Comparative Examples, the residual amount of peroxide was periodically evaluated while storing in a constant temperature and humidity chamber (high temperature (40 ℃)).

Compared to Examples 1, 2, 3 and Comparative Examples 1, 2, and 3 in the <Table 3>, the other compositions had a difference in stability with time at high temperatures depending on the amount and the presence of the peroxide stabilizer. .

In addition, when comparing Example 3 and Comparative Examples 1, 2, and 3, even though the peroxide stabilizer was not added, the product produced in solid was found to be more stable than the product manufactured in wet type.

Claims (7)

Solid tooth whitening agent manufactured using a polymer and a separate stabilizer to stabilize the whitening component for the purpose of teeth whitening. Here, solids have a hardness value in the range of 50 to 200. Solid products stored in an incubator at 25 ° C for 1 hr are measured by a Rheometer called UDS-200 manufactured by Physica (USA). It is the value from the moment the string connected to the adapter touches the product after cutting it up until the product is completely cut off. The method according to claim 1, wherein the raw materials are mixed in a liquid state and dried to make a solid tooth whitening agent having a stabilized whitening component. The method according to claim 1, wherein the semi-finished product in a solution state prepared in order to make a solid tooth whitening agent stabilized whitening ingredient is put into a molding mold and then hardened. The method according to claim 1, wherein the raw materials are mixed directly in an extruder and extruded in order to make a solid tooth whitening agent stabilized whitening component. The whitening component of claim 1 added for the purpose of tooth whitening is peroxides, chlorine bleaches, polyphosphates, Vit-Es, enzymes such as dextranase, papain, where peroxides are hydrogen peroxide, urea peroxide, sodium percarbonate. , Sodium perborate, calcium peroxide, sodium pyrophosphate, and the like, and chlorine-based bleaching ingredients include sodium hypochlorite. The polyphosphate is potassium pyrophosphate, sodium pyrophosphate, acidic pyrophosphate, sodium metaphosphate, sodium polyphosphate, potassium pyrophosphate and the like. Solid tooth whitening agent using the component selected from 1 or more types from these. The method of claim 1, wherein the polymer for stabilizing the tooth whitening component is cellulose gum, bentonite, carbopol, hydroxyethyl cellulose, hydroxymethylcellulose, hydroxypropyl cellulose, polyvinyl alcohol, polyvinylacetate, pectin, starch, xanthan Gum, polyalkyl vinyl ether-maleic acid copolymer (PVM / MA copolymer, Gantrez AN 149, AN 139, S-97), polyacrylic acid, Poloxamer 407 (Pluronic), polyvinyl pyrrolidone-vinyl acetate copolymer (PVP / VA copolymer; Luviskol VA, Plasdone S PVP / VA), polyvinyl pyrrolidone (PVP, K-15-K-120), Polyquaterium-11 (Gafquat 755N), Polyquaterium-39 (Merquat plus 3330), hydroxypropyl Methylcellulose, gelatin, sodium alginate, polyvinyl acetate, ethyl cellulose, polymethyl methacrylate, methacrylic acid copolymer, methacrylic copolymer, amino alkyl methacrylate copolymer Solid tooth whitening agents, such as cellulose acetate phthalate and polyethylene glycol, made using at least one selected from them. According to claim 1, in addition to the polymer stabilizer is added to further stabilize the whitening component candelillan, beeswax, paraffin lead, wood lead, carbauna lead, ceresin, glycerin tri-2-ethylhexyl acid, liquid paraffin, capryl Ric / capric triglycerides, alkyl aryl sulfonates, alkyl sulfonate salts, alkyl carboxylate salts, alkyl diphenyl oxide disulfonates, Span 20, Sorbitan Monolaurate, Span 40, Sorbitan Monopalmitate. Span 60, Sorbitan Monostearate, Span 80, Sorbitan Monooleate, Span 85, Sorbitan Trioleate, TWEEN (POE sorbitan fatty acid ester) Solid tooth whitening agent to make.