EA010030B1 - Tooth paste - Google Patents

Abstract

The invention relates to stomatology and perfumery, more specifically to tooth paste, the tooth paste comprises inert components, including anhydrous base, as well as active components comprising carbamide peroxide in an amount of 8.0 – 12.0 mass % and micronized polyethylene wax as an abrasive filler and peroxide stabilizer in an amount of 10.0 – 30.0 mass %.

Description

The invention relates to dentistry and the perfume industry, and specifically to toothpaste.

Known toothpaste, which includes glycerin, propylene glycol, silicon oxide, carbamide peroxide, gelling agents based on processed starch, aluminum oxide, surfactants, anti-caries additive - sodium monofluorophosphate, pH regulators, papain, polyacrylic acid , sodium saccharinate, peppermint flavoring (I8 B2 No. 6511654, IPC 7 A61K 7 / 16,2003).

The carbamide peroxide, which is part of the well-known paste, provides effective tooth whitening, when interacting with the residual moisture, always present in the paste prepared according to known technologies, is destroyed with the formation of hydrogen peroxide and urea, and then the reaction proceeds with the formation of reactive oxygen species: Н-О- O-, -O-O-, -O-, as well as O ₂ , ΝΗ ₃ , H ₂ O and CO ₂ . Thus, during prolonged storage, a decrease in the concentration of active oxygen occurs, and natural gas formation in the closed packaging volume of the toothpaste leads to its bloating, and often to integrity disruption.

In addition, during the preparation of a toothpaste of known composition, it is necessary to heat the mixture to a temperature of at least 87 ° C (87-140 ° C) to completely swell starch derivatives, which leads to an increase in energy costs for the production of the product.

The problem to which the present invention is directed is to create a toothpaste that provides effective whitening, including by incorporating a peroxide compound. A long storage time of prepared toothpaste in packaged form should be ensured without loss of consumer qualities. The composition of the toothpaste should allow its preparation without the use of heating operations to temperatures above 60 ° C.

This problem is solved in the preparation of toothpaste, which includes inert components, including an anhydrous base, as well as active components, which include carbamide peroxide in the amount of 8.0-12.0 wt.% And micronized polyethylene wax as an abrasive filler and a peroxide stabilizer in an amount of 10.0-30.0 wt.%.

Micronized polyethylene wax is a spherical particle with a diameter of 510 microns with a smooth, even surface, due to which it has good cleaning and slight abrasive properties, eliminating the injury to the surface of tooth enamel. However, it is known that the stabilizing effect on peroxides is associated with the adsorption phenomena of additives (hydrogen peroxide and peroxide compounds. Edited by prof. M.E. Pozin, GNTIHL, 1951, p.268). Micronized polyethylene wax in the developed composition is just such an additive, because due to the highly developed hydrophobic surface it has a protective, enveloping effect, stabilizing peroxide and thereby ensuring the stability of the composition. It is the latter circumstance that avoids bloating of individual packaging (polyethylene or aluminum tubes) when stored at room temperature.

In a preferred embodiment, the toothpaste additionally contains calcium glycerophosphate as active components, and as inert components the paste contains xylitol, aluminum oxide, PEG-40 hydrogenated castor oil, alkylamidobetaine, peppermint flavoring and, as an anhydrous base, propylene glycol, polyacrylic acid, tromethamine and glycerin, in the following ratio of the listed components, wt.%:

Calcium Glycerophosphate 0.10-0.25 Xylitol 2.0 - 3.0 Aluminum oxide 2.0 - 8.0 PEG-40 Hydrogenated Castor Oil 0.8-1.2 Alkylamidobetaine 0.8-1.2 Mint fragrance 0.3 - 0.7 Propylene glycol 20.0 - 25.0 Polyacrylic acid 0.6 - 2.0 Trometamine 0.2 - 0.6 Glycerol Up to 100

In the manufacture of the developed composition in a preferred embodiment, including carbamide peroxide and micronized polyethylene wax, it is not necessary to heat the paste to temperatures above 60 ° C, since the composition does not contain components for which a significant mass heating is required to bring the suspension into a state. Accordingly, reduced energy costs for production

- 1 010030 the finished product.

As a mint fragrance, a fragrance based on refined peppermint oils or its mixture with methyl salicylate is used. It is not advisable to use other fragrance options, since there is a high probability of oxidation of fragrance components and, accordingly, a negative change in aroma.

To confirm the possibility of carrying out the invention below in table. 1 presents examples of specific formulations and describes the technology for the preparation of toothpastes in accordance with the present invention.

Table 1

Composition number 1 | Composition No. 2 Composition No. 3 Concentration /about Propylene glycol 20,0 23.0 25.0 Carbamide peroxide 8.0 10.0 12.0 Micronized Polyethylene Wax 10.0 15.0 30,0 Aluminum oxide 8.0 5,0 2.0 Xylitol 2.0 2,5 3.0 Polyacrylic acid 2.0 1,2 0.6 Alkylamidobetaine 0.8 1,0 1,2 PEG-40 hydrogenated castor oil 0.8 1,0 1,2 Mint fragrance 0.6 0.4 0.3 Trometamine 0.6 0.4 0.2 Calcium Glycerophosphate 0.10 0.20 0.25 Glycerol up to 100% up to 100% up to 100%

The preparation of toothpastes in accordance with the developed formulation is as follows:

weigh the required amount of glycerol, to which propylene glycol and xylitol are added; all mix until a homogeneous mass is formed;

at high speeds of the mixing device (800-900 rpm), polyacrylic acid is slowly added and mixed until the latter is evenly distributed, while the mixture is heated to 50-55 ° C;

the mixing device is turned off and the mixture is kept for 30-40 minutes to swell the polyacrylic acid;

again turn on the mixing device and mix the composition to obtain a viscous homogeneous gel;

calcium glycerophosphate, aluminum oxide and micronized polyethylene wax are added to the resulting gel; the mixture is stirred until a homogeneous mass is formed, after which it is cooled to a temperature of 20-25 ° C; if necessary, the mixture is homogenized and vacuum;

then carbamide peroxide is slowly added and the mixture is stirred until a homogeneous mass is formed;

add tromethamine and mix until a homogeneous mass is formed;

add alkylamidobetaine and mix until a homogeneous mass is formed;

a pre-prepared mixture of PEG-40 hydrogenated castor oil with peppermint fragrance from peppermint oil and methyl salicylate is loaded into a mixer with a paste and mixed until a homogeneous pasty mass is formed.

The process described above is valid for both the preparation of the compositions presented in table. 1, and for the preparation of any other toothpastes in accordance with the invention.

The effectiveness of the developed toothpaste was evaluated by changing the content of active oxygen in the composition No. 1 (table. 1). As a composition for comparison, we used a sample of Tobgapb! Toothpaste prepared according to the recipe in accordance with the analogue described above (No. 8 B2 No. 6511654, IPC 7 A61K 7 / 16,2003).

The content of active oxygen was measured in the initial state of the compositions and after storage for 3 weeks at room temperature (18-22 ° C), as well as at elevated temperature (40 ° C). The content of active oxygen was carried out iodometrically.

The results of the analysis are presented in table. 2.

- 2 010030

table 2

Time The content of active oxygen,% mass. Temperature 18 - 22 ° С Temperature 40 ° С Composition No. 1 Composition for comparison Composition No. 1 Composition for comparison Source 1.3 1,0 1.3 1,0 After 3 1,1 0.8 - tube strongly 0.7 less than 0.1 - tube weeks swollen exploded

Based on the tab. 2 data we can conclude that the proposed composition provides stabilization of the peroxide compounds and eliminates the bloating of individual packaging when stored at room temperature.

An example of the use of toothpaste composition No. 2 (table. 1) as intended:

Patient E., 26 years old, complained of an unsatisfactory cosmetic appearance of the teeth.

At the first inspection it was established:

The color of the teeth on the Uye scale is Ώ4, the gloss is not enough.

The patient is prescribed to use the specified toothpaste for cleaning instead of the usual paste daily for 2-3 minutes for a period of 4 weeks.

Re-examination after 4 weeks.

Upon re-examination revealed: the color of the teeth on a scale Uya - 1) 2, the brilliance of the teeth has become more intense. There are no complaints.

Thus, the tooth enamel surface was lightened by 4 tones.

Claims (3)

CLAIM 1. Toothpaste containing inert components, including an anhydrous base, as well as active components, which include carbamide peroxide in the amount of 8.0-12.0 wt.% And micronized polyethylene wax as an abrasive filler and stabilizer of peroxide in the amount of 10 0-30.0 wt.%. 2. Toothpaste according to claim 1, characterized in that it also contains calcium glycerophosphate as active components, and as inert components the paste contains xylitol, aluminum oxide, PEG-40 hydrogenated castor oil, alkylamidobetaine, peppermint flavoring and as anhydrous bases propylene glycol, polyacrylic acid, tromethamine and glycerin, in the following ratio of the listed components, wt.%: Calcium Glycerophosphate 0.10-0.25 Xylitol 2.0-3.0 Aluminum oxide 2.0-8.0 PEG-40 Hydrogenated Castor Oil 0.8-1.2 Alkylamidobetaine 0.8-1.2 Mint fragrance 0.3 - 0.7 Propylene glycol 20.0 - 25.0 Polyacrylic acid 0.6-2.0 Trometamine 0.2 - 0.6 Glycerol Up to 100 3. Toothpaste according to claim 2, characterized in that the fragrance based on refined peppermint oils or a mixture of perfume based on refined peppermint oils with methyl salicylate is used as a mint fragrance.