KR20050034568A - Branched-amino acid supplement food - Google Patents

Abstract

The present invention relates to a health functional food using a branched chain amino acid among essential amino acids to increase the instantaneous impact power in the anaerobic state, and more particularly, essential ingredients contained in milk, eggs, beans, beef, etc. existing in nature. Increases instantaneous impact power in an anaerobic state, including branched chain amino acids consisting of leucine (L), isoleucine (I), valine (V), and so on, similar to amino acids It relates to a health functional food using a branched chain amino acid among essential amino acids.

By ingesting the branched chain amino acid supplement food according to the present invention to athletes such as taekwondo player, golf player, martial arts player, football player, baseball player, judo player, wrestler, volleyball player, basketball player, soccer player, Increasing the concentration of essential amino acids in the blood of athletes, reducing the breakdown of muscle glycogen has the effect of suppressing the decrease in muscle strength.

Description

BRANCHED-AMINO ACID SUPPLEMENT FOOD using branched chain amino acid among essential amino acids to increase instant impact power in anoxic state

The present invention relates to a health functional food using a branched chain amino acid among essential amino acids that increase instantaneous impact power in anoxic state, and more specifically, similar to essential amino acids contained in milk, eggs, beans, beef, etc. existing in nature. Among the essential amino acids to increase the instantaneous impact power in the anaerobic state, including branched chain amino acids (hereinafter referred to as "LIV") consisting of leucine (L), isoleucine (I), valine (V) It relates to a health functional food using a branched chain amino acid.

An important factor in exercise is firstly the mind control to exercise, the second is proper nutrition, and the third is sufficient rest. Attention to exercise and sufficient rest in the above important factors can be solved by one's own effort and time, but nutrition is not.

Accordingly, the present inventors have disclosed powder maltodextrin, fructose, glucose, protein, collagen, as disclosed in Korean Patent Publication No. 10-2003-0013836 (published on Feb. 15, 2003, application number 10-2001-0048037). (Gelatin), taurine, L-glutamine, citric acid, glucosamine, vitamins, posa and chondroitin, Cordyceps sinensis, L-carnitine, aminosilk, caramix, guar gum, geneabia, octacosanol, gardenia green, fruit flavor A nutritional supplement for sports is developed.

However, the conventional sports citation nutritional supplements contain a variety of nutrients that act as a source of energy in the body by ingesting before or after a marathon or a vigorous exercise that must be continuously run for a long time, but Taekwondo that requires intense muscle activity Proper composition ratio to prevent the breakdown of muscle glycogen by athletes, football players, baseball players, judo players, wrestlers, basketball players, soccer players or golf players, volleyball players, martial arts players who require instant muscle power There has been a need for the development of new dietary supplements containing branched chain amino acids that do not cause muscle loss.

Athletes' calorie intake is determined by the calorie consumption associated with exercise, and nutrient needs vary with intensity and time of exercise and with the type of exercise. In the case of Korean athletes, the nutritional recommendation (RDA) is 1.5 to 2 times that of the general public, 3,000 to 5,000 kcal / day for male athletes and 2,500 to 3,500 kcal / day for female athletes. For endurance athletes with more than 1.0g / day daily protein requirement, 1.2-1.4g / day per kilogram of body weight and 1.4-1.8g / day per kilogram of body weight for active athletes are recommended. .

Protein is one of the most important nutrients for athletes. The reason why athletes have a high requirement of protein unlike general people is that protein is used as energy source during exercise. Especially during weight training, muscle protein breaks down so that the muscles that are consumed are compensated to their original state. This is to activate the protein synthesis.

According to the needs of the development of such a new dietary supplement, the present inventors, 35% of the muscle cells are composed of leucine (leucine), isoleucine (isolucine), valine (valine), the muscle growth and development Essential branched-chain amino acids (BCAAs) are essential amino acids, and because they cannot be synthesized in the body, they have to be supplied through food or supplements.

In particular, it is noted that the three branched chain amino acids help the synthesis of other amino acids required for muscle composition, promote insulin production, and are absorbed and metabolized faster in the muscle than the liver, unlike other amino acids.

Accordingly, the present inventors investigated the composition of essential amino acids contained in various foods, and by examining the minimum required amount of essential amino acids for infants, children, and adults, the daily required amount of the branched chain amino acids suggested in the recommended nutritional amount of Koreans Recognizing that the branched chain amino acids contained in dietary foods such as milk, eggs, soybeans, beef, and wheat is a digestive absorption pattern of Koreans, supplementing branched chain amino acids by the average ratio of the branched chain amino acids of the dietary foods To develop food.

In order to achieve the above object, leucine (L), which is used as a nutrient for wound recovery and blood sugar reduction, isoleucine (I) necessary for hemoglobin formation, and valine, which converts sugars of liver and muscle into energy, Intensive investigation analysis and experiments were performed on the ribs (V) and the like.

Protein intake is essential for improving muscle strength, but not all of it is used for muscle synthesis. If it is ingested more than necessary, it cannot be stored in the body, so it is eventually burned as an energy source.Amino groups of amino acids are not completely burned in the body and are excreted outside the body, and the amount of calcium excreted increases with metabolism such as liver and kidney. Affects. Therefore, supplementation of LIV is necessary as a way to meet and supplement the negative effects on athletes' protein intake.

Liv (LIV) consists of approximately 70% of muscle protein and is consumed during prolonged intense exercise, such as glycogen. Because carbohydrates are the main energy source used during exercise, rib supplements (LIV), which are known to offset muscle protein destruction during intense exercise, have emerged. However, disagreements have arisen because experimental protocols have not yet been established to yield accurate results for LIV studies. Ingestion of ribs (LIV) is recognized by many experts as to their effects on muscle recovery after ingestion.

The features and main functions of LIV are as follows.

1. Delayed muscle breakdown-prevents muscle breakdown.

2. Improve Nitrogen Equilibrium

3. Promote energy generation-Promote energy generation in endurance-related movements.

4. Increase muscle building

5. Energy generation material in muscle

6. Reasonably helps muscle and energy metabolism.

7. Assist protein synthesis and minimize protein disruption.

8. Involved in the recovery, growth and development of muscle tissue.

9. It is an important calorie source of skeletal muscle tissue used during exercise.

10. Promote the synthesis of proteins and inhibit protein degradation.

11. Three branched chain amino acids should always be taken together to meet the required function.

12. Increase carbohydrate utilization.

13. Helps muscle cells form muscle tissue.

14. Promote the synthesis of proteins in muscle cells.

15. Metabolized in muscle cells.

16. Leucine, isoleucine, and valine should be balanced.

Leucine, isoleucine, and valine are called branched chain amino acids because their shape is intertwined like branched chains. It is important.

In the present invention, in order to balance and harmonize three branched chain amino acids, ribs (LIV) present in milk, eggs, soybeans, beef, wheat, etc., which exist in nature, were analyzed (see Table 1). Reference is made to the minimum required amount of LIV in essential amino acids of children and adults (see Table 2).

<Table 1> LIV content of foods in nature

<Table 2> Minimum LIV Required for Humans (mg / kg body weight / day)

Since the minimum required amount of the adult's rib (LIV) in Table 2 is based on the final rib absorbed by the human body, the human body should be absorbed by the human body by oral supplementation and finally absorbed by the human body. Attention was drawn to the average proportion of ribs (LIV) in the dietary foods of Table 1, and accordingly, ribs (LIVs) included in dietary foods such as milk, eggs, beans, beef, wheat, etc. Recognized that the Korean is a digestive absorption pattern, and developed a branched chain amino acid supplement food by the average ratio of the rib (LIV) of the diet.

The branched chain amino acid supplement according to the present invention comprises 70% rib (LIV) composed of 45% by weight of leucine, 25% by weight of isoleucine, and 30% by weight of valine, and the remaining 30% is L-glutamine 20 It contains 1% of taurine, 9% of taurine and other vitamins and minerals.

The rib (LIV) may be composed of 40 to 50% by weight of leucine, 20 to 30% by weight of isoleucine, and 25 to 35% by weight of valine.

Leucine is used to reduce blood sugar levels and as a nutrient for wound healing, isoleucine is required for hemoglobin formation, and valine is an amino acid that converts sugars in the liver and muscle into energy.

The total branched chain amino acid supplement contains 65-75% rib (LIV) and 15-25% L-glutamine (20-35% of the weight of the LIV), which is essential for excessive exercise, stress and overwork. , 5 to 15% of taurine (7 to 20% of the weight of the LIV), is an antioxidant and various other vitamins and minerals required to help the absorption and metabolism of the rib (LIV) 2% or less (the LIV of 0.01% to 2.9% of the weight).

L-Glutamine promotes protein synthesis in muscles, prevents muscle loss, speeds up muscle recovery, helps fast muscle growth, and is a rich free amino acid in the body that makes up 60% of the total amino acids. Although it is synthesized by the body, glutamine in muscles is rapidly used when the body is under stress by training and exercise, and thus it is an essential essential amino acid which must be ingested in athletes to prevent muscle maintenance and stamina.

Taurine is an aminoethylsulfonic acid that has the properties of a positive electrolyte like amino acids. The main physiological functions of taurine are bile formation, cholesterol concentration control, ionic cell membrane permeability, antioxidant activity, and excessive nervous excitability. . They are found in cells of the heart, skeletal muscle, brain, and reproductive organs rather than body fluids. Taurine has been known as a cardiovascular drug because it weakens the contractile force of the heart when the heart's calcium ion concentration is lower than normal. It also forms bile acids and polymers to mitigate the toxicity of bile acids and help the intestines absorb fat. Taurine protects cells by removing peroxides, nitrogen oxides, and free radicals from cell membranes before they damage the cell membranes. Taurine has the highest concentration of amino acids in the brain and, when the nerves are constantly excited, suppresses excessive nerve excitement and has a nerve stabilizing effect, reducing stress caused by exercise.

L-glutamine and taurine, which are essential for excessive exercise, stress and overwork, have been added to LIV to enhance the function of branched chain amino acid supplements.

Branched-chain amino acid supplements contained 20-35% of the weight of the rib (LIV) in the L-glutamine and 7-20% of the weight of the rib (LIV) in the taurine.

Athletes need to take proper antioxidant nutrients, which include vitamins C, E, and β-carotine. Representative vitamin C is important for the synthesis of collagen (collagen myofoprotein) in connective tissues, and is an energy metabolic cytochrome ( It helps digestion and absorption of minerals and iron that make up cytochromes. In addition, histamine elimination, a substance secreted in response to stress, plays an important role in regulating the condition of exhausted athletes due to continued competition.

Free radicals, which are by-products produced by the body's biological activities, normally occur in energy production in the body, metabolism of lipids or proteins, catecholamine reactions, and various inflammatory reactions, but are mostly neutralized by antioxidants. In addition, cardiovascular diseases such as hypertension, arteriosclerosis, and coronary artery disease, malignant tumors, chronic inflammatory diseases, Parkinson's syndrome, epilepsy, various brain injuries, cataracts, skin cancers, autoimmune diseases, etc. This is known to play a very important role.

During exercise, the body's oxygen demand increases rapidly. Because a lot of oxygen is consumed in active muscles, many free radicals are produced, which damage cell membrane structures, and the researchers found that these damages are related to increased products of the oxidation process immediately after exercise.

Free radicals generated by athletes under stress under prolonged exercise may result in changes in cell membrane fluidity, permeability and excitability, or in the action of enzymes attached to the cell membrane. In general, oxidative stress caused by free radicals can be said to be all the cells that make up the body, and the representative ones are lipids, proteins, DNA, nucleic acids, and enzymes. . In addition, strenuous exercise requires more than 20 times the average muscle oxygen demand, so the suddenly increased oxygen demand causes hypoxia and lactic acid accumulation, leading to muscle fatigue.

Intense exercise increases free radicals, which destroy cells and promote aging, but they are neutralized by antioxidant nutrients and can have greater effects by controlling the type, intensity and time of exercise.

To the antioxidant activity as described above and to support the absorption and metabolism of the rib (LIV) was added to nine vitamins and five minerals. The vitamins and minerals are vitamin A, vitamin C, vitamin B1 hydrochloride, vitamin B2, vitamin B6 hydrochloride, vitamin B12, vitamin D3, folic acid, nicotinamide, calcium phosphate, iron, magnesium oxide, zinc oxide, maltodextrin and the like.

In order to confirm the efficacy of the branched chain amino acid supplements as described above, 48 male athletes who are active as taekwondo athletes at K and Y colleges were selected from three groups, namely placevo group (LIV 0g, 16 persons each according to LIV intake). / day administration, PSG), half supplemented group (LIV 2.5g / day administration, HSG), full supplemented group (LIV 5.0g / day administration, FSG) was divided into oral intake for 12 weeks.

The supplied ribs (LIV) were supplements containing 70% of the ribs (LIV) per capsule. The composition ratio of isoleucine, leucine, and valine was 1: 1.8: 1.2.

Since the recommended amount of ribs for athletes has not been suggested yet, the daily supply (5.0 g) was twice the daily recommended amount for the general public, and was taken immediately before and after exercise.

The study period ranged from January 7, 2002 to March 30, 2002, at the beginning of the winter camp training. It was divided into exercise (10: 00 ~ 12: 00), afternoon exercise (15: 00 ~ 17: 30), and night exercise (19: 30 ~ 21: 00). On Saturdays, only morning exercise was performed. Was carried out.

Serum level of amino acids

Graphs of the amino acid content in blood are shown in FIGS. 1 and 2.

Figure 1 is for essential amino acids and Figure 2 is for non-essential amino acids.

Blood analysis showed that isoleucine was significantly increased in all groups after supplementation, and leucine and valine were only increased in HSG and FSG.

Histidine, an essential amino acid, decreased significantly after supplementation in PSG and HSG, but significantly increased in FSG. Lysine, methionine and phenylalanine were significantly increased in all groups after supplementation, and threonine was significantly increased in HSG and FSG.

In non-essential amino acids, alanine, glycine and tyrosine were significantly increased in HSG and FSG, arginine and serine were significantly increased only in FSG, and aspartic acid and glutamine were significantly increased in all groups after supplementation.

Maximum anaerobic power

The results of the investigation on the maximum oxygen free power are shown in Table 3.

PSG was 1,318.1 ± 159.9watts before supplementation, HSG and FSG were 1,402.1 ± 177.9watts and 1,346.9 ± 150.0watt, respectively, but there were no differences between the three groups, but at 12 weeks of supplementation, PSG was 1,300.3 ± 130.3watts and HSG and FSG were 1,401.1 ± 239.2watts and 1,445.4 ± 161.3watts were significantly higher in FSG (P <0.05). FSG significantly increased after supplementation than before supplementation (P <0.01).

The results of power divided by body weight were 17.9 ± 2.1watt / kg before supplementation, 18.8 ± 2.3watt / kg and 18.7 ± 1.6watt / kg for HSG and FSG, respectively. The PSG was 17.5 ± 12.7watt / kg, HSG and FSG were 18.7 ± 1.8watt / kg and 20.4 ± 2.3watt / kg, respectively (P <0.05). FSG significantly increased after supplementation than before supplementation (P <0.01).

<Table 3> Comparison of maximum oxygen free power by group

Therefore, in the group (FSG) administered 5.0 g / day of the rib (LIV), it is determined that not only leucine, isoleucine, valine but also other amino acids are significantly increased to improve the maximum anaerobic power.

As described above, the branched chain amino acid supplement food according to the present invention is ingested to athletes such as taekwondo players, golf players, martial arts players, soccer players, baseball players, judo players, wrestlers, volleyball players, basketball players, and soccer players. In addition, it increases the concentration of essential amino acids in the blood of athletes, and reduces the breakdown of muscle glycogen has the effect of suppressing the decrease in muscle strength.

In addition, it can be used as a health functional food to improve the performance of individual sports such as golf, taekwondo, martial arts, and professional athletes. It can be used as a health functional food to increase the adaptability to strength, increase the training incentives for athletes, improve the quality of labor and improve the quality of exercise, affect the reduction of blood sugar and amino acid in muscle Increasing the amount of nutrients can be used as a dietary supplement as a scientific nutritional supplement for diabetics, and is expected to be used as a dietary supplement that can overcome various obstacles caused by physical fatigue.

1 is a graph of blood concentrations of essential amino acids for each experimental group in a study according to the present invention.

Figure 2 is a graph of the blood concentration of non-essential amino acids for each experimental group in the study according to the present invention.

Claims (5)

In the branched chain amino acid supplement food, Leucine (L) 40 to 50% by weight, 20-30% by weight of isoleucine (I), Valine (V) Health functional food using a branched chain amino acid among essential amino acids to increase the instantaneous impact power in the anoxic state containing ribs (LIV) consisting of 25 to 35% by weight. The method of claim 1, On the rib (LIV), Health functional food using branched chain amino acid among essential amino acids to increase instant impact power in anoxic state that contains L-glutamine and taurine. The method of claim 2, The el-glutamine is 20 to 35% of the weight of the rib (LIV), The taurine is a health functional food using a branched chain amino acid of essential amino acids to increase the instantaneous impact power in the anaerobic state, characterized in that 7 to 20% of the weight of the rib (LIV). The method of claim 3, Branches of essential amino acids that increase instantaneous impact power in the anaerobic state in which the ribs containing L-glutamine and taurine are additionally contained in the vitamin and minerals of 0.01% to 2.9% of the weight of the ribs (LIV). Health functional food using chain amino acid. The method of claim 4, wherein The vitamins and minerals are vitamin A, vitamin C, vitamin B1 hydrochloride, vitamin B2, vitamin B6 hydrochloride, vitamin B12, vitamin D3, folic acid, nicotinamide, calcium phosphate, iron, magnesium oxide, zinc oxide, maltodextrin Health functional food using branched chain amino acid among essential amino acids to increase instant impact power in anoxic state.