KR20040076179A - The stick for the oral product - Google Patents

Abstract

PURPOSE: A stick for whitening tooth surfaces containing tooth whitening substance in a solid stick which is in the form of O/W, W/O, W/O/W and O/W/O is provided. It can be selectively applied to a desired tooth without falling down during coating and foreign body sensation. CONSTITUTION: The stick for whitening tooth surfaces comprises: a tooth whitening substance selected from peroxides, a chlorine-based bleaching agent, a polyphosphate, vitamin E, enzyme and sodium bicarbonate; and titanium dioxide, hydroxy apatite, titanated mica or pigments of various colors. The stick has a hardness of 40 to 150 and is made using an emulsion system. The peroxides are selected from hydrogen peroxide, urea peroxide, sodium carbonate peroxide, sodium perborate, calcium peroxide and sodium pyrophosphate peroxide. The emulsion system is O/W, W/O, W/O/W and O/W/O.

Description

Tooth Whitening Stick {The stick for the oral product}

The present invention relates to a stick for tooth whitening. More specifically, the present invention relates to a preparation of a tooth whitening stick and a tooth whitening agent.

As our society enters advanced countries, interest in teeth whitening continues to grow. To meet these needs, many kinds of tooth whitening products have been released, but due to their problems, consumer satisfaction is not very high.

In the traditional method using toothpaste and toothbrush, the actual use time is short and it is difficult for consumers to feel the effect. To improve this, EP 0511782A devised a coating for tooth whitening. This product has a viscosity of 30,000 ~ 50,000cps, so it can flow down after application or open mouth and dry the coating solution. In fact, a similar phenomenon occurs in the simply white tooth whitening coating solution released by US Colgate. USP 5824,291 contains a tooth whitening agent in the gum base and the tooth whitening component is released during chewing and reacts with the contaminants of the teeth to cause the whitening effect of the tooth. Insignificant In USP5891453, a gel containing a tooth whitening component is applied to a thin film (polyethylene) and then attached to the tooth itself. P & G's Crest Whitestrips product manufactured in this way has many improvements in usability due to discomfort in the mouth and contamination of the hands and clothes due to gel when used.

Therefore, the present invention has been invented a tooth whitening stick in a new formulation to overcome the problems of the formulation. It was manufactured using emulsification system and made into O / W, W / O, W / O / W, O / W / O according to the compatibility of tooth whitening ingredients with other raw materials.

As an example of the manufacturing process, the O / W emulsification system was described. The mixture was stirred and heated with an oily base such as wax, and was gradually added to the liquid mixed with a water-soluble polymer with water, a moisturizer, and a tooth whitening component under stirring. The hardness of the finished product was about 40 ~ 150 (measured by rheometer at 30 ℃, speed 20mm / min, cutting 10mm), and it is similar to that of ordinary lipstick, so there is no fear of dripping like coating liquid when applied to teeth. After the aqueous phase component was applied to the teeth, oil components such as wax components were applied to prevent it from being easily washed off by saliva. In addition, since it is coated on the teeth with a thin film, it has excellent usability such as no foreign matter in the mouth.

The present invention relates to a new formulation that exerts a tooth whitening effect while having excellent usability as described above.

In order to have both the tooth whitening efficacy and usability, the present invention has developed a tooth whitening formulation of a new formulation containing a tooth whitening component on a solid stick.

In addition to the tooth whitening ingredients, titanium, mica titanium and pigments can be added to give the surface of the teeth a gloss, white and color effect.

Hereinafter, the present invention will be described in more detail.

In the present invention, the water phase [W] is water, alcohol, glycerin, sorbitol, propylene glycol, butylene glycol, ceramide, polyethylene glycol and at least one selected from the components of cellulose gum, bentonite, carbopol, hydroxyethyl cellulose , Hydroxymethylcellulose. One or more selected ingredients from water-soluble polymers such as hydroxypropyl cellulose, povidone, polyvinyl alcohol, polyvinylacetate, pectin, starch, xanthan gum and the like are mixed to form a base. The content of the water-soluble polymer is suitably in the range of 0.1 to 20% more preferably 0.5 to 5% by weight relative to the mixture with the moisturizing component. If it is less than 0.1%, the viscosity is so low that after mixing with the oil component, the final product may lose its viscosity and eventually the hardness of the product may be lowered, causing it to clump even in a weak impact. On the contrary, at 20% or more, the viscosity may be too high for the process and may not dry well after tooth application.

Tooth whitening ingredients include peroxides, chlorine bleaches, polyphosphates, Vit-E, enzymes such as dextranase and papain, and one or more selected ingredients from them can be used. Here, the peroxides include hydrogen peroxide, urea peroxide, sodium percarbonate, sodium perborate, calcium peroxide, sodium pyrophosphate, and the like, and chlorine-based bleaching components include sodium hypochlorite. Polyphosphates include potassium pyrophosphate, sodium pyrophosphate, acidic pyrophosphate, sodium metaphosphate, sodium polyphosphate, potassium pyrophosphate and the like. If you want a tooth cosmetic effect, you can mix titanium dioxide, mica titanium or other pigments. The tooth whitening component may be mixed with an aqueous or oily phase depending on the characteristics of each component such as stability and solubility.

Wax may be a component corresponding to the oil phase [O], and may include candelillan wax, beeswax, paraffin lead, wood lead, carbauna lead, and ceresin. The wax is blended in an amount of 1 to 35%, preferably 3 to 30% in the total amount of the oily base. Oily oil components include tri-2-ethylhexyl glycerol, castor oil, liquid paraffin, caprylic / capric triglycerides, and the like. The oil component is preferably 10 to 75%, preferably about 20 to 70%. At less than 10%, the wax is softly mixed and the effect of applying a slippery coating is weak, and it is difficult to polish the teeth. On the other hand, more than 75% is not desirable because you will taste the unique taste of the oil.

Surfactants may be used in both the oil phase and the water phase, with low HLB values for the oil phase and high for the water phase.

Examples thereof include sorbitan isostearate, sorbitan oleate, sorbitan sesquioleate, and the like. The emulsifier is suitably 0.2 to 10%, preferably 2 to 5%, on an oily base. If the amount of the emulsifier is less than 0.2%, if the emulsifying power is insignificant and 10% or more, the usability may be reduced by the taste of the emulsifier.

Hereinafter, the configuration and effect of the present invention will be described in more detail with reference to Examples and Comparative Examples. The embodiments are provided to assist in understanding the configuration of the present invention and the present invention is not limited thereto.

EXAMPLE

[Production Method O / W of Example 1]

1) After weighing and heating the raw material belonging to the mixture A, dissolve it by stirring.

2) After weighing and heating the raw material belonging to the mixture B, it is dissolved by stirring.

3) Mixture B is added to A as 1: 1. Emulsify for about 10 minutes using a homogenizer.

4) Stir using a mixer to room temperature, cool and store at room temperature.

Preparation Method W / O of Example 2

1) After weighing and heating the raw material belonging to the mixture A, dissolve it by stirring.

2) After weighing and heating the raw material belonging to the mixture B, it is dissolved by stirring.

3) Mixture A is added to B as 1: 1. Emulsify for about 10 minutes using a homogenizer.

4) Stir using a mixer to room temperature, cool and store at room temperature

[Production Method W / O / W of Example 2]

1) Except for hydrogen peroxide in the raw material belonging to the mixture A, it is basically weighed and heated, and then dissolved by stirring.

2) After weighing and heating the raw material belonging to the mixture B, it is dissolved by stirring.

3) Mixture A is added to B as 1: 1. Emulsify for about 10 minutes using a homogenizer.

4) The raw materials belonging to the mixture A, except for sodium bicarbonate, are weighed and heated, and then dissolved by stirring.

5) The solution made in 3) is added to 4) as 1: 1. Emulsify using homogenizer for about 10 minutes

6) Stir using a mixer to room temperature, cool and store at room temperature

The manufacturing method is added to the water phase and the oil phase according to the hydrophilicity or lipophilic properties of the tooth whitening component, but the tooth whitening component is not necessarily added to the water phase (or oil phase) just because it is hydrophilic (or lipophilic). Among the teeth whitening ingredients, sodium bicarbonate and hydrogen peroxide were all mixed well with water, but they were not compatible with each other, so they made W / O / W phase and added to the front and rear water phase, respectively.

[Comparative Example]

Conventional tooth whitening formulations such as toothpaste, coatings and adherent tooth whitening agents are prepared.

Comparative Example 1

Toothpaste is prepared by combining cellulose gum 2%, hydrogen peroxide (35% solution) 10%, silica 20%, glycerin 30%, water to 100, and defoaming.

Comparative Example 2

10% PVP, 10% hydrogen peroxide (35%) and ethanol to 100 are formulated to create a whitening coating formulation for teeth whitening.

Comparative Example 3

Carbopol 10%, hydrogen peroxide (35%) 10%, glycerin 10%, pH adjuster, water to 100 The above ingredients are mixed to make a gel and then applied to a thin film (polyethylene) to form a tooth-adhesive tooth whitening agent.

Tooth whitening effect evaluation

The best way to evaluate the tooth whitening effect is to apply it to real teeth. The subjects were selected only with teeth darker than A3, referring to the Trubyte ¹⁾ (color ordered) Shade Guide. The change in the initial color was recorded. In addition, the survey was conducted after use to evaluate the degree of whitening.

Test progress: 20 groups of men and women will be assigned to each group.

The usage and dosage of each group was used according to the characteristics of the product and used for 2 weeks as follows.

Examples 1-3: Apply to tooth twice a day.

Comparative Example 1: Brush with a toothbrush twice daily.

Comparative Example 2: Apply to tooth twice a day.

Comparative Example 3: Attached to Teeth Twice a Day

1) Trubyte (color ordered) Shade Guide: It is similar to tooth shape and classified into 24 levels according to the change of color.

2) Evaluate yourself to 4 points if you have teeth whitening

1: No whitening effect 2: Minor whitening effect 3: Fully recognized whitening effect 4: Excellent whitening effect

Example is superior to the tooth whitening effect compared to Comparative Examples 1 and 2, first, because the tooth whitening component can be continuously delivered to the tooth can be maintained for a long time without flowing down when applied to the tooth. Similarly, Comparative Example 3 (tooth-adhesive whitening agent) also showed an effect because it can be continuously attached to the teeth and deliver the whitening component. On the other hand, toothpaste and whitening components of the whitening type (simply white type) were diluted by intraoral acupuncture after tooth application and the actual effect was insignificant. Second, oil components remained in the teeth to prevent dilution by saliva. Third, the formulation was made using an emulsification system. Raw materials that were not compatible with each other in consideration of compatibility with tooth whitening ingredients and other ingredients were separated into aqueous and oil phases, so the stability of the product was excellent. It was able to achieve a quick effect.

Tooth whitening and hydrogen peroxide, which are tooth whitening ingredients, were manufactured and put into the W / O / W system as described in the manufacturing method so that the whitening effect was increased (synergy) without deteriorating stability in the product.

Usability Evaluation

Clinical subjects were asked to evaluate the experience of using the product.

Usability Rating Scale

1: poor 2: slightly poor 3: moderate 4: good 5: excellent

As a result of the evaluation of the feeling of use, the product of Example 2 had the best result, and it was thought that the satisfaction was higher among the examples because the teeth were beautifully made up using mica titanium. On the other hand, the toothpaste of Comparative Example 1 had a high score due to its ease of use. The tooth whitening coating solution of Comparative Example 2 was inconvenient because it requires a drying process after tooth application. Comparative Example 3 was a good tooth whitening effect in clinical evaluation, but did not satisfy the feeling of use. This is because the gel-coated film is attached to the teeth, so the foreign matter is large and it interferes with conversation.

As described above, the stick formulation is easy to apply to the tooth. Due to the present invention, there is no dripping and drying process of the tooth whitening component on the tooth, and the coating film is thin and can selectively act only on the tooth that wants the whitening effect without foreign matter. In terms of formulation, emulsification system can be used for the poor compatibility of raw materials without impaired stability over time.

Claims (10)

Stick Formulation for Teeth Whitening The tooth whitening component of claim 1, which is added for the purpose of tooth whitening, includes peroxide, chlorine bleach, polyphosphate, vitamin-E, enzyme, sodium bicarbonate, and the like. According to claim 1, Tooth whitening purposes include tooth cosmetics, stick-type formulations characterized in that the mixed use of titanium dioxide, hydroxyapatite, mica titanium or various pigments The stick-type formulation according to claim 1, wherein the formulation is made using an emulsification system. The stick formulation according to claim 1, wherein the formulation has a hardness of 40 to 150. The peroxide according to claim 2 is at least one selected from hydrogen peroxide, urea peroxide, sodium percarbonate, sodium perborate, calcium peroxide, sodium pyrophosphate and the like. The chlorine bleach according to claim 2 is sodium hypochlorite or the like. The polyphosphate of claim 2 is at least one selected from potassium pyrophosphate, sodium pyrophosphate, acidic pyrophosphate, sodium metaphosphate, sodium polyphosphate and potassium pyrophosphate. The enzyme according to claim 2 is at least one component selected from dextranase, papain and the like. The stick type formulation according to claim 4, wherein the emulsifying system is O / W, W / O, W / O / W, O / W / O.