KR20040073895A - Fabrics for Inducing Deep Sleep and for Promoting Secretion of Growth Hormone and Clothes prepared thereby - Google Patents

Abstract

PURPOSE: Fabric is characterized by having sleep inducing effect and growth hormone secretion promoting effect, promoting the circulation of blood and having constant humidity function and constant temperature function. Therefore, clothes produced out of the fabric is useful for functional clothes. CONSTITUTION: Fabric having sleep inducing effect is obtained by the steps of: preparing microcapsule extract of safflower seed, zizyphi spinosi semen, achyranthes root, dioscorea rhizome, cornus fruit, moutan bark, hoelen, alisma rhizome, cyperus rhizome, cimicifuga rhizome, wheat germ, drynaria fortunei, phellodendron bark and whey mineral; and then infiltrating the fabric into the extract.

Description

Fabrics having a good night's sleep-inducing effect and promoting growth hormone secretion and clothing made of them {Fabrics for Inducing Deep Sleep and for Promoting Secretion of Growth Hormone and Clothes prepared hence}

The present invention relates to a fabric having a good sleep-inducing effect and growth hormone secretion effect, and a garment made thereof, and more particularly, microencapsulated safflower seed, sanjoin, dew, acid powder, cornus milk, baekjak, baekbokyeong, taksa, hyangbuja, The present invention relates to a fabric having a deep sleep-inducing effect impregnated with an extract of horse riding, malt, bone clavicle, yellowish white and whey mineral and promoting growth hormone secretion, and to a garment made of the same.

Sleep is classified into REM (Rapid eye movement) sleep and Non-REM sleep according to the presence or absence of eye movement, and non-REM sleep is a shallow sleep according to the depth of sleep. Divide into 3 and 4 levels of sleep. The following diagram is called a sleep chart, which charts the stages of sleep. Steps 3 and 4 are called slow wave sleep and represent deep sleep stages.

[Table 1] Stages of sleep and patterns of brain waves during sleep

As shown in the diagram above, alpha waves are reduced in the first stage and theta waves of 3-7 Hz are predominant, spindle waves are generated in the second stage, and delta waves appear characteristically in the third stage. Grows The next stage is stage 4, and stages 3 and 4 are called slow wave sleep.

Proper sleep is an essential component of a healthy life, and adequate sleep can improve your health by affecting tissue recovery, immune system, and mental functioning, while lack of sleep can lead to fatigue, decreased mood, and reduced pain tolerance. Obstacles to activity The sleep quality is affected by the indoor environment, the physiological factors of the human body, bedding, etc. More specifically, the temperature and humidity of the bedroom, noise, light, fatigue of the human body, conditions of bedding and the like.

During sleep, fever in the human body decreases, but skin vessels expand and skin temperature rises, increasing the amount of fever. Therefore, since the heat exchange between the human body and the environment occurs faster and the amount of heat is increased and the body is easier to cool down than during the daytime activities, the body needs to warm the body more than during the daytime activities (Kim, Myung-ok, Choi Jeong-hwa (1991) A Study on Post-psychological Psychophysiology and Human Physiological Responses. In particular, the study found that the important factors that hinder the sleep of adolescents are cold and heat (Park Hyun-sook, Kim Kyung-deok, Kim Kyung-hye, Jung Bok-rye. (2000) Comparison of sleep quality and sleep disturbance factors of adolescents, adults and the elderly. In consideration of this, it can be seen that the maintenance of temperature and humidity during sleep is important for a good night's sleep.

Sleep has an energy conservation function that replenishes energy consumed during the day by lowering body temperature without moving the body, and plays an important role in the development of the central nervous system. However, modern people are not getting a good night's sleep due to heavy work and academic stress.

Sleep disorders result in diminished activity and sleepiness during the day by increasing total bedtime, and psychological and social phenomena such as fatigue, confusion, instability and concentration disorders may occur due to lack of sleep. In addition, prolonged sleep deprivation results in dizziness, instability, attention disorders, sensory disturbances, and transient hydration.

Factors that inhibit sleep in patients hospitalized to recover from illness can easily lead to sleep disorders due to proximity to others, and do not allow daily activities at home or adjust sleep habits to care providers. It is also an obstacle. Sleep disorders in these rooms are obstacles to the patient's recovery.

Looking at the conventional techniques for inducing a good night's sleep, Korean Utility Model Registration No. 2002-0011390 inserts a haptic oscillator that converts an acoustic signal output from an acoustic device into a vibration in a pillow to prevent the generation of α waves by the vibration. Pillows are disclosed that can induce and promote sleep.

In addition, various functional products such as a bed mattress for inducing a good night's sleep and a mat for a good night's sleep are being marketed, but clothes which can be easily worn as a general pajamas or patient's patient clothes have not been developed yet. to be.

Therefore, there is a need in the art for a patient clothing that can take a good night's sleep for those who are experiencing a rapid recovery and lack of sleep or sleep disorders in a hospital.

On the other hand, in general, there are several rhythms in the living body to efficiently control various functions of the living body, the most important of which is the 24-hour circadian rhythme (circadian rhythme).

This rhythm is controlled not only by the internal clock located in the cerebrum, but also by an external factor called zeitgerbers, which includes the intensity and position of the sun, artificial light, meals, clocks, working hours, and low-frequency electromagnetic fields. , Weather and sleep time. The most powerful Zyteger is weather time.

The closest change according to the rhythm is the body temperature, where the body temperature descends with the start of sleep and starts to rise from the dawn, maintaining the maximum in the activity time.

In addition, among the biological hormones, growth hormone, prolactin, corticosteroids, thyroid stimulating hormone, and the like are regulated by the rhythm (Min Sung Gil et al. (1999).

Sleep rhythms (sleep cycles) exist within circadian rhythms and are closely related to each other. Non-REM sleep and REM sleep have different endocrine and physiological functions. For example, growth hormone is secreted the most in relation to non-REM sleep, and prolactin is secreted depending on REM sleep.

Therefore, sleep and growth hormone are deeply related. According to the results reported so far, growth hormone secretion shows the maximum secretion form during nighttime sleep and no secretion during night sleep deprivation. It is also known that growth hormone secretion reappears when you go back to sleep (Roffwarg, HP, Sachar, EJ Halpern, F. and Hellmann, L. (1982) .Plasma testosterone and sleep: relationship to sleep stage variables.Psychosomatic Medicine 44-73. Spiegel, K., Leproult, R., Colecchia EF, L'Hermite-Baleriaux, M., Nie, Z., Copinchi, G., and Van Cauter, E. (2000). Adaption of the 24-h growth hormone profile to a stte of sleep debt.American Journal of Physiology: Regulatory Integrative Comparative Physiology, 279.R874-883, Gronfier, C., Luthringer, R., Follenius, M., Schaltenbrand, N ., Macher, JP, Muzet, A., and Brandenberger, G. (1996) .A quantitative evaluation of the relationships between growth hormone secretion and delta wave electroencephalographic activity during normal sleep and after enrichment in delta waves.Sleep 19. 817- 824).

Drug stimulation tests are known as idiopathic nephropathy, in which normal reactions and no specific cause are identified.In this case, the growth hormone concentration and the maximum value of growth hormone secretion were measured when the growth hormone concentration was measured by continuous blood collection for 12 hours. It is reported that the number of times is lower than that of a normally growing child.

In addition, studies on the relationship between growth hormone secretion and nighttime sleep patterns showed that sleep hormone deficiency showed abnormal REM sleep (Astrom C. Interaction between sleep and growth hormone.Evaluated by manual). polysomnography and automatic power spectrum analysis.Acta Neurol Scand (1995) 92 (4): 282-296, Review). Mendlewicz J, Linkowski P, Kerkhofs M, Leproult R, Copinschi G, VanCauter E. Genetic control of 24-hour growth hormone secretion in man: a twin study.J Clin Endocrinol Metab. (1994) 84 (3): 856-862 ).

Applicant of the present application has been filed and registered as a Korean patent application No. 1998-0013707 for growth promoting health supplement composition containing safflower seed, duchung, baekbokyeong, bokbunja, earth and sand and green and calcium.

In addition, Korean Patent Application No. 2001-0065100 discloses a pharmaceutical composition and health foods for inducing IGF-1 secretion, comprising a pharmaceutically effective amount of a Soktu extract, which is prepared by a simple process from Sokdan, a herbal medicine. In addition, a number of pharmaceutical compositions for promoting the secretion of growth hormone have been patented (Korean Patent Application No. 2002-7016614, Korean Patent Application No. 2002-0035768, Korean Patent Application No. 2002-7001095).

However, in addition to the pharmaceutical compositions and health foods as described above, there are no fabrics and garments made thereof that can be easily worn on a regular basis to promote secretion of growth hormone.

Therefore, there is an urgent need in the art to develop fabrics having a growth hormone secretion promoting effect and a garment made of them in order to alleviate the growth disorder caused by the lack of growth hormone caused by the slow wave sleep disorder.

Figure 1 is a chart comparing the thermal conductivity of the fabric of the present invention camisole and other materials.

Figure 2 is a chart comparing the body temperature when wearing a garment made of 100% cotton and jamisol of the present invention, respectively.

3 is a diagram showing the effect of the clothing having a sleep-inducing effect and growth hormone secretion promoting effect of the present invention on the sleep stage.

Figure 4 is a chart showing the effect of the growth hormone secretion clothes having a sleep-inducing effect and growth hormone secretion promoting effect of the present invention.

An object of the present invention is to provide a good sleep induction effect impregnated with extracts of microencapsulated safflower seed, sanjoin, hyssop, medicinal herbs, cornus, baekjak, baekbokyeong, taxa, hyangbuja, horse riding, malt, bone clasp, yellow and white and whey mineral (whey mineral) which is achieved by the fabric and provide a garment (a jami ^Sol? huh manufacturing Co., Ltd. in bojin) produced by them.

Another object of the present invention is the growth hormone secretion impregnated with extracts of microencapsulated safflower seed, sanjoin, hyssop, powder, cornus, earl, baekbokryeong, taeksa, hyangbuja, horse riding, malt, bone clam, yellow white and whey mineral It is achieved by providing a clothing (the jami ^Sol? manufactured by Corporation allowed bojin) made of fabric and those having a promoting effect.

Clothing having a good sleep-inducing effect and growth hormone secretion effect of the present invention can be produced by known fibers used in the art, preferably made of a mixed fiber of 52% polyester and 48% polyolefin .

[Table 2] Composition of the fabric used for the manufacture of clothes having a sleep-inducing effect and growth hormone secretion effect of the present invention

Scientific name Polyolefin Polyester Specific gravity (g / cm3) 0.91 1.38 Thermal conductivity 6 7.3 Process water content (%) 0.05 0.45 Melting Point (℃) 162 250

Common name Scientific name Creation costs safflower seed Carthamus tinctorius L. 13.5% zizyphi spinosi semen (sanjoin) Zizyphus jujuba MILLER 9.01% achyranthes root (wool) Achyranthes japonica LEVEILLE et VANIOT 9.0% dioscorea rhizome Dioscorea japonica Thunberg 7.2% cornus fruit Cornus officinals SIEBOLD et ZUCCARINI 7.2% moutan bark Paeonia moutan SIMS 4.5% hoelen (baekbokyeong) Poria coccos WOLF 4.5% alisma rhizome (taxi) Alisma orientale JUZEPCZUK 4.5% cyperus rhizome Cyperus rotundus L. 4.5% cimicifuga rhizome (riding) Cimicifuga heracleifoliaKOMAROW 4.5% wheat germ (malt) Hordeum vulgare L. 4.5% Drynaria fortunei Drynaria fortunel SMITH 4.5% phellodendron bark Phellodendron amureenseRUPRECHT 4.5% whey mineral 18%

Among the constituents of grommon α, safflower seed is a drawing board of safflower, a herbaceous herb that is a year-old herb, which enhances the function of bone tissue cells, promotes bone development, and accelerates bone damage caused by fractures or sprains. To restore bone density and to increase the bone density.

Baekbokryeong belongs to the mushroom family of poops, and is an indeterminate form of parasite that lives in Songsu-geun (松樹 根). This drug strengthens digestive function so that nutrients are well absorbed, stabilizes heart function, eliminates stress, and gets a good night's sleep according to the height of sleep.

In addition, bone clavicle is good for breaking bones because it has the effect of connecting the broken bones, when molar hurts and shakes, bleeding crushed bone bone 80g is a medicinal herb that is often used in gums.

Clothing having a sleep-inducing and growth hormone secretion effect of the present invention manufactured as described above has a low thermal conductivity (FIG. 1), a constant temperature effect (FIG. 2) and an antimicrobial effect (Table 1). 4).

Table 4 Antimicrobial Effects of Gromon α

division Early bacterial count Number of bacteria after 18 hours General Textile Gromon α Staphylococcus 130,000 4.9 million (38 times more bacteria) 10 or less (sterilization rate: 99.9%) Pneumococcal 120,000 5.2 million (43 times more bacteria) 10 or less (sterilization rate: 99.9%)

The results of animal experiments on gromon α showed that, in 216 piglets, the experimental group treated with gromon α had a bone density of 42.8% (mean: average 1, control: 0.7) and spine length 6.8 compared to the control group without gromon α. % (Experimental group: average 64cm, control group: average 59.9cm) increased.

In addition, the experimental group showed an increase in blood growth hormone levels of the average of 45% compared to the control group after 2 weeks of administration, indicating that gromon α is effective in the growth of piglets.

Hereinafter, the present invention will be described in more detail with reference to Examples, but the following Examples are only for illustrating the present invention and are not intended to limit the scope of the present invention to the Examples.

Example 1 Selection of Subject

Sleeping effect of the clothes having the sleep-inducing effect of the present invention was measured in 17 children without growth, physical and endocrine defects, similar physical strength and exercise time. The mean age of 17 patients was 12.3 years (standard deviation 2.17 years), average height was 162.1cm (standard deviation 4.28cm), and mean weight was 56.3kg (standard deviation 3.31kg).

During the control experiment, subjects were allowed to wear cotton-made garments. The cotton-made garments used in the control experiment were manufactured to be indistinguishable from the clothes having the sound-inducing effect of the present invention. There was no.

There was a 2-week washout period between experiments in the control and experimental groups, and none of the subjects had nighttime sleep disturbances (snoring, sleep apnea, bruising) or children taking medication.

Example 2 Conducting a Sleep Polymorphism Test

Nighttime polysomnography was performed for a total of 7 hours and 30 minutes from 10 pm to 5:30 am the next day, and was computerized polysomnography of Respironic's Alice3 model. Was used.

Sleep results for each group recorded were read according to Rechtschaffen and Kales reading standards. Sleep stages were divided into wake, stage 1, 2, 3, 4, and stage eye movement (REM), and deep sleep was defined as the sum of stage 3 and stage 4.

Sleep results were analyzed by calculating total sleep time (450: total sleep time), bed time (TIB, Time in bed), and sleep efficiency (%) = TST / TIB * 100. As a result, the experimental group showed higher sleep efficiency than the control group.

[Table 4] Comparison of sleep parameters during night sleep

Sleep parameters Experimental group Control Bed time 450.9 ± 4.5 450.0 ± 3.9 Total sleep time 409.9 ± 8.0 401.4 ± 8.3

As a result of comparing the sleep structures of the experimental group and the control group, the experimental group had significantly higher levels of sleep than the control group. In addition, the ratio of the slow wave sleep (SWS) showing deep sleep was also higher in the experimental group than the control group (Fig. 3).

[Table 5] Comparison of sleep structure during night sleep

Sleep stage Experimental group Control Wake 8.3 ± 2.2 10.5 ± 1.2 Step 1 9.39 ± 3.1 15.2 ± 2.5

Example 3 Measurement of Growth Hormone Changes During Sleep

To measure the growth hormone changes during sleep, 9 times (60 hours, 2 hours, 3 hours, 4 hours, 5 hours, 5 hours, 2 hours, 23 hours, 24 hours, 1 hour, 2 hours, 3 hours, 5 hours, 5 hours) 40 minutes), and 5 ml of blood were collected at each blood collection. In order to minimize sleep disturbances due to blood collection, blood was collected with a three way catheter inserted in the forearm.

Nocturnal blood collection was performed 2 hours prior to the sleep plural test to reduce the effects and burden of hormones caused by catheterization. To minimize the hormonal effects of food intake, people should eat as usual and eat 4 hours before sleep. Ingestion was allowed.

In order to minimize hormonal concentration change due to the inflow of catheter-connected saline into the blood during sleep, 5 ml of blood was removed after the first 2 ml of blood collection, and blood samples collected continuously were separated and refrigerated. Stored.

The concentration of growth hormone was analyzed by radioimmunoassay (RIA). 100 μl of a standard sample, a control sample, and a test sample were added to the beads coated with the antibody. 100 ml of the growth hormone antibody indicated by I ¹²⁵ was added, the reaction was carried out with a rotator at room temperature for 3 hours, and then the beads were washed to measure radiation with a gamma-counter.

As a result of the experiment, 60 minutes after the start of sleep, the secretion of growth hormone showed the maximum value, and the experimental group showed 2.4 times higher value than the control group (FIG. 4). In addition, the experimental group showed a tendency to increase the growth hormone level slightly from 3 am, the control group showed a tendency to slowly decrease after the maximum secretion.

Example 4 Investigation of Sleep Satisfaction

The visual similarity scale developed by Cline et al. (1992) was used to investigate the quality of sleep. Draw a line of 10cm to the horizontal line and make a scale from 0 to 100 so that 0 at the left end is "not very satisfactory" and 100 at the right end is "very satisfactory". To be displayed. As a result, the sleep satisfaction (83%) of the experimental group was higher than the control group (72%).

Example 5 Determination of Influence on the Emotional Index

Twenty healthy volunteers (3 males, 17 females; average age: 25 years old) of 20 healthy adults were measured for the effect of the clothes having the effect of promoting sleep sleep and growth hormone secretion on the sensitivity index.

Each subject banned cigarettes, caffeine, and drugs 6 hours before the experiment, and rested (20 minutes), wore normal cotton clothing (10 minutes), measured menstrual signals and examined psychological status, rested (10 minutes), and worn miramisol clothing ( 10 minutes), physiological signal measurement and psychological state investigation in order.

Anxiety, depression, fatigue, and stress were displayed on a horizontal line on a visual analogue scale (VAS) to subjectively assess the subject's feelings. "No at all" is 0 and "very is not" as 100, indicating that the higher the score, the more severe the symptoms. Emotion was measured using the SAM tool.

The instrument used for the collection and analysis of physiological signals was QECG-3 manufactured by LAXTHA, and the ECG measurement time was fixed at 5 minutes.

As a result of the experiment, the anxiety, depression, fatigue and stress felt by the subjects were reduced after wearing and the emotional index was significantly increased compared to before wearing the clothes having the sleep-inducing and growth hormone secretion effect of the present invention.

variable Before wearing After wearing unrest 48.9 ± 19.3 27.0 ± 19.4 depressed 33.0 ± 20.2 24.2 ± 21.5 Emotion 0.05 ± 1.27 1.5 ± 0.8 Fatigue 64.0 ± 19.3 37.9 ± 19.4 stress 58.8 ± 22.16 40.7 ± 18.6

In addition, as a result of comparing the heart rate of the subject before and after wearing the clothing having the sleep-inducing and growth hormone secretion promoting effect of the present invention, it showed a significant decrease from 70.4 times before wearing to 65.7 times after wearing. In addition, the value of LF / HF was also reduced by 30% after wearing compared to before wearing.

As described above, the clothing having a sleep-inducing and growth hormone secretion promoting effect of the present invention not only has blood circulation promoting function, constant humidity and constant temperature function, but also has an effect of inducing a good night's sleep, grow by increasing the amount of sleep wave sleep It is effective in releasing hormones.

Therefore, it can be used as a functional clothing for fast recovery of patients admitted to the room and sleep of people suffering from sleep deprivation or sleep disorder, and can also be used to alleviate growth disorders due to lack of growth hormone.

Claims (5)

Fabrics having a good sleep-inducing effect impregnated with microencapsulated safflower seed, sanjoin, hyssop, medicinal herb, cornus, pear pear, baekbok-ryeong, taeksa, hyangbuja, horse riding, malt, bone clam, yellow and white and whey mineral. Microencapsulated safflower seed, sanjoin, hyssop, medicinal herb, cornus, earl pear, baekbokyeong, taeksaek, hyangbuja, horse riding, malt, bone clam, yellow baekw and whey minerals are fabrics made of a good sleep-inducing effect impregnated cloth. The garment according to claim 2, wherein the garment is a patient garment. A fabric having a growth hormone secretion effect impregnated with microencapsulated safflower seed, sanjoin, hyssop, medicinal herb, cornus, pear pear, baekbok-ryeong, taeksaek, hyangbuja, horse riding, malt, bone clam, baekbaek and whey mineral. A microencapsulated safflower seed, sanjoin, hyssop, medicinal herb, cornus, earl pear, baekbokryeong, taeksaek, hyangbuja, horse riding, malt, bone clam, baekbaek and whey mineral impregnated with growth hormone secretion Made garments.