KR20040049704A - Formulation for skin protection with the anti-inflammation effect and for the improvement of the skin appearance - Google Patents

Abstract

PURPOSE: A composition containing hydrophylic liquid carriers, skin protection agents, thickening agents, anti-inflammatory components, skin whitening agents or the like is provided. It is effective in alleviating erythema, acne, skin inflammation or the like caused by UV and IR as well as protecting the skin and improving a skin appearance. CONSTITUTION: The anti-inflammatory and skin appearance improving composition comprises 99.98% by weight of a hydrophylic liquid carrier, 0.01 to 10% by weight of a polymerizable thickener, 0.01 to 10% by weight of a natural anti-inflammatory component, 0.01 to 10% by weight of a skin whitening agent and 0.01 to 10% by weight of a reflecting particular material with a mean particle size of about 10 to 100nm. The skin whitening agent is selected from Broussonetia papyrifera extract, licorice extract, kojic acid, arbutin, ascorbic acid and a mixture thereof. The natural anti-inflammatory component contains candelilla wax, alpha-bisabolol, aloe vera, seaweed extract, laverder, chamomile, tea tree or the like.

Description

Formulation for skin protection with the anti-inflammation effect and for the improvement of the skin appearance}

Technical Field

The present invention relates to topical compositions, such as skin care soothing compositions, which improve incomplete skin appearance and skin condition and at the same time are effective for soothing skin with anti-inflammatory action. More specifically, the present invention relates to a topical skin care composition that provides a good coverage of skin imperfections, such as an unbalanced skin tone, so that the skin maintains its natural appearance, and the anti-inflammatory ingredients alleviate skin problems. .

Background

In recent years, accelerated skin aging, skin problems, and skin sensitization occur due to harmful skin environments, and in particular, many skin problems are caused by stress. In particular, most skin problems such as acne and skin irritation result in a poor appearance of the skin, and especially in the process of treating the skin, the appearance of the skin becomes irritated and sensitive and protects the skin from external exposure. It is necessary to do

Locally available to provide immediate skin appearance improvement for the use of numerous compounds to control the appearance and condition of the skin, including the appearance of irritated skin, such as uneven and rough surface tissue and inflammation associated with debris, wrinkles and aging or photo damaged skin. It would be beneficial to provide a composition.

One approach to this is to introduce particulates such as TiO ₂ into the skin care composition. For example, the emulsion may contain TiO ₂ as an opaque agent that gives the emulsion a white appearance. Commercial sunscreen compositions may use such particles to impart sunscreen effects. Several publications also disclose the use of TiO ₂ in skin care compositions. For example, US Pat. No. 5,223,559 and patent applications DE 245815, WO 94/9756 and JP 8188723. mention the use of optical means to formulate a product that provides an immediate and visible improvement to the consumer, referring to the skin as a reflective material such as TiO ₂ . It is disclosed that the line can be mechanically peeled. However, it was mentioned that such reflective materials result in an undesirable mask-like appearance, so that a sufficiently transparent material should be used to disperse the light but avoid the mask-like appearance.

Known topical compositions containing reflective materials such as TiO ₂ typically do not provide sufficient coating to reduce the appearance of skin imperfections, or when applied to the skin, the skin appears excessively white resulting in an unnatural appearance. It has also been found that materials that primarily disperse light rather than reflect light do not provide a good coating of skin imperfections when used in an aesthetically acceptable amount to consumers. More specifically, when used at relatively high concentrations to provide a coating, these materials cause excessive skin incomplete appearance.

In addition, the reflective granular material such as TiO ₂ gives a dry touch, and excessive content causes the particle composition to cause troubles on the skin, but rather causes side effects that irritate the skin. Also reflective particulates tend to agglomerate, such as agglomerate, so that when these materials agglomerate, larger amounts of particulate material are needed to provide sufficient coverage, which also increases negative action. Therefore, it would be desirable to realize an aesthetically acceptable degree of skin coverage even with relatively low concentrations of TiO ₂ .

In addition, the cosmetic composition preferably has good aesthetics during and on application to the skin. Good aesthetic means that the composition is (i) light and non-lipid, (ii) soft and silky on the skin, (iii) easily spread, and (iv) quickly absorbed. Such a desirable aesthetic is often achieved by introducing thickeners into the composition. However, it is known that particulate materials such as metal oxides are often incompatible with many thickeners and skin protection actives, such as carboxylic acid polymers, making them unusable.

The present invention has improved the aggregation of particulate matter and incompatibility with other thickeners and compositions by using surface treated reflective particulate material with charges dispersed in the thickened hydrophilic carrier. Charged surface treated reflective particulates can be (i) compatible with polymeric thickeners, such as carboxylic acid polymers, (ii) providing acceptable skin coverage at relatively low concentrations, and (iii) good It has been found in the present invention that it can be formulated into a composition with aesthetics. Such compositions are particularly suitable for providing immediate visual improvement in skin appearance when used locally.

In view of this, it is an object of the present invention to provide a topical composition suitable for imparting immediate visual improvement in skin appearance.

Another object of the present invention is to provide a skin topical application composition that is excellent in anti-inflammatory effect against skin irritation such as acne, inflammation, soothing and protecting skin from various skin problems.

The present invention relates to a skin care composition that provides an immediate visible improvement and anti-inflammatory effect of skin appearance upon topical application to the skin. Such compositions comprise (A) about 1 to about 99.98 weight percent of a hydrophilic liquid carrier, (B) about 0.01 to about 10 weight percent of a polymerizable thickener and (C) about 0.01 to about 10 weight percent of a composition And from about 0.01% to about 10% by weight of the natural anti-inflammatory component (D) composition with a reflective particulate having an electric charge having an average net particle size of from about 10 nm to about 100 nm. Charged particulates are dispersed throughout the thickened hydrophilic liquid carrier, and such compositions provide a coverage efficiency ratio of at least 50.

In addition, natural anti-inflammatory components can be obtained as extracts that are physically or chemically appropriately extracted from natural sources such as plants, fungi, microbial by-products, candelilla wax, alpha bisabolol, aloe vera, manzistar, gugal, cola extract , Seaweed extract, lavender, chamomile, tea tree and the like.

The compositions described herein are preferably in the form of emulsions and contain reflective particulates with charges such as coated metal oxides. As a further preferred embodiment, the present invention relates to a composition containing at least one compound selected from the group consisting of a skin protectant, a skin lightening agent, a sunscreen and combinations thereof in an additional composition.

The compositions of the present invention may consist or consist essentially of the essential and optional ingredients described herein. As used herein, the term `` mainly composed '' means that the composition or component may contain additional components, provided that the additional components do not substantially alter the basic and novel properties of the claimed compositions and methods. All percentages and ratios used herein are parts by weight of the total composition, and all measurements were made at 25 ° C. unless otherwise indicated.

As used herein, the term "local application" means applying the composition of the present invention to the skin surface.

The term ″ dermatologically acceptable ″ as used herein means that the composition or component thereof described is suitable for use on human skin without excessive toxicity, incompatibility, instability, allergic reactions, and the like.

As used herein, the term ″ safe effective amount ″ is sufficient to induce a positive benefit, preferably a positive skin appearance or touch, independently, including the benefits described herein, but to cause serious side effects. By a sufficiently low, i.e. within the scope of good medical judgment, the amount of a compound, ingredient or composition that provides a reasonable benefit to the risk ratio.

Active agents and other ingredients useful herein may be classified or described herein by their cosmetic and / or therapeutic benefits or their presumed mode of action. However, it is to be understood that the active agents and other ingredients useful herein may in some cases provide one or more cosmetic and / or therapeutic benefits or act through one or more modes of action. Therefore, classification is made here for convenience and not in particular for limiting the ingredients to the stated or listed applications.

The compositions of the present invention are useful for providing a fairly immediate visible improvement in skin appearance after topical application and skin application of the composition. Without being bound by theory, it is believed that this rapid skin appearance improvement results from the therapeutic coating or masking of skin imperfections, at least in part, by charged particulate matter. The composition provides visible benefits without the unnaturalness of unacceptable skin appearance such as whitening the skin.

More specifically, the compositions of the present invention may include, but are not limited to, visible and / or tactile heterogeneity in skin tissue and / or skin color, including but not limited to control of visible and / or tactile heterogeneity on the skin. It is useful for regulating skin condition, including heterogeneity associated with skin aging and heterogeneity due to skin problems such as acne and inflammation. Such heterogeneity may be induced or induced by internal and / or external factors. External factors include ultraviolet (eg, due to sun exposure), environmental pollution, wind, heat, low humidity, harsh surfactants, abrasives, and the like. Internal factors include aging with age and other biochemical changes from inside the skin.

Control of skin conditions includes control of prophylactic and / or therapeutic skin conditions. As used herein, prophylactic skin condition control includes delaying, minimizing and / or preventing visible and / or tactile heterogeneity in the skin. As used herein, therapeutic skin condition control includes improving, such as reducing, minimizing and / or eliminating such inhomogeneities. Skin condition control is accompanied by improvements in skin appearance and / or feel, such as providing a softer, more even appearance and / feel. As used herein, skin condition control includes skin problems caused by stimulation and control of symptoms of aging.

″ Control of skin aging symptoms ″ includes prophylactic and / or therapeutic control of one or more of these symptoms (similarly, given symptoms of skin aging, such as control of gold, wrinkles or pores, and prophylactic and And / or therapeutic adjustments.

″ Symptoms of Skin Aging ″ include, but are not limited to, all visible and tactilely recognizable signs and any other macro or micro consequences of skin aging. Such symptoms may be induced or induced by internal or external factors such as chronological aging and / or environmental damage. Such symptoms may include wrinkles, skin deposits, cracks, bumps, large pores (such as those associated with appendages such as sweat glands, sebaceous glands or hair follicles), insulting, flaky and / or uneven skin, including fine superficial wrinkles and coarse, deeply folded wrinkles Other forms of roughness, loss of skin elasticity (loss and / or inactivation of functional skin elastin), sag (including swelling around the eyes and lower jaw), loss of skin firmness, loss of skin tension, loss of skin recovery from deformation Hyperpigmented skin areas such as discoloration (including the lower part of the eye), staining, paleness, aging spots and freckles, keratin, abnormal differentiation, hyperkeratization, elastosis, collagen breakdown, and the stratum corneum, dermis, epidermis and skin vascular system ( Eg, capillary dilated or arachnoid) and tissues, including but not limited to the development of tissue heterogeneity such as wrinkles, including tissues adjacent to the skin. It is not limited.

It is to be understood that the present invention is not intended to be limited to the regulation of the above-mentioned "symptoms of skin aging" caused by mechanisms related to skin aging, but to the control of these symptoms independent of the mechanism of origin.

"Stimulation skin problems" includes prophylactic and / or therapeutic control of one or more of these symptoms. “Stimulation skin trouble” includes acne and inflammation caused by excessive sebum secretion and skin waste, skin irritated and irritated by acne, inflammation, skin sensitization by UV and external harmful environment, skin irritation, erythema, stressed skin Trouble, skin exfoliation in the treatment of the skin includes conditions associated with skin conditions that are fatal to external exposure and skin conditions that require urgent soothing or regeneration.

The present invention is particularly useful for therapeutically controlling the heterogeneity of visible and / or tactile heterogeneity in mammalian skin, including heterogeneity in skin tissue and color. For example, the apparent diameter of the pores decreases, the apparent height of the tissue closest to the pore opening approximates the height of the intertracheal skin, the skin tone and / or color become more uniform, and / or the length, depth of the wrinkle or wound And / or other diameters are reduced.

The composition contains granules with charge dispersed throughout the thickened hydrophilic carrier and skin soothing and regenerating ingredients, and the charge-bearing granule allows the composition to have a coating efficiency ratio of 50 or more to help improve skin tone's immediate appearance. In addition, it contains anti-inflammatory ingredients and has excellent effects on soothing effects such as ultraviolet erythema, acne, and skin irritation. The present invention may also contain various optional ingredients. The essential and preferred components of the composition and the preparation and use of the composition are described in detail below:

1. Hydrophilic Liquid Carrier

The composition of the present invention comprises a hydrophilic liquid carrier, such as water or other hydrophilic diluent, from about 1 to about 99.98 weight percent, preferably from about 5 to about 95 weight percent, more preferably from about 20 to about 90 weight percent, based on the composition. It contains. Thus, the hydrophilic liquid carrier may contain water or a combination of water and one or more water soluble or dispersible ingredients. Hydrophilic liquid carriers containing water are preferred.

The hydrophilic liquid carrier component may contain any dermatologically acceptable carrier that can incorporate essential thickeners, reflective particulates and any other materials to allow the particulates and optional components to be delivered to the skin at appropriate concentrations. The hydrophilic liquid carrier thus ensures that the particulate material is applied to the selected target at a suitable concentration and evenly distributed.

The carrier may contain one or more dermatologically acceptable semisolid or liquid fillers, diluents, solvents, extenders, and the like. The liquid carrier may also contain gel material. Preferred carriers are substantially liquid. The carrier itself may be inert or possess a dermatological benefit by itself.

The concentration of the hydrophilic liquid carrier may vary depending on the carrier selected and the intended concentration of the required and optional ingredients.

Suitable hydrophilic carriers include known carriers that are conventionally or otherwise dermatologically acceptable. The carrier must also be physically or chemically compatible with the essential ingredients described herein and must not unduly impair stability, efficacy or other use advantages with respect to the compositions of the present invention. Preferred components of the composition of the present invention should be able to be mixed with each other in such a way that there is no interaction that substantially reduces the efficacy of the composition under normal use conditions.

The type of hydrophilic carrier used in the present invention depends on the type of product type desired for the composition. Topical compositions useful in the present invention can be prepared in various types of products known in the art. This includes, but is not limited to, lotions, creams, gels, sprays, pastes, powders, mousses, and cosmetics (such as semi-solid or liquid makeup, foundations, eye makeup, dyed or undyed lip treatments, etc.) It doesn't happen. Such product types may contain, but are not limited to, various types of carriers including solutions, aerosols, emulsions, gels and liposomes.

Preferred hydrophilic carriers may contain a dermatologically acceptable, non-aqueous hydrophilic diluent. Non-limiting examples of hydrophilic diluents include organic hydrophilic diluents such as lower monohydric alcohols (e.g. C ₁ -C ₄ ) and low molecular weight glycols and propylene glycols, polyethylene glycols (e.g. molecular weight 200-600 g / mole), polypropylene glycols ( Eg molecular weight 425-2025 g / mole), glycerol, butylene glycol, 1,2,4-butanetriol, sorbitol ester, 1,2,6-hexanetriol, ethanol, isopropanol, sorbitol ester, butanediol, ether Organic hydrophilic diluents such as polyols, including propanol, ethoxylated ethers, propoxylated ethers and combinations thereof.

As described below, the hydrophilic liquid carrier may contain various components that are water soluble or water miscible, capable of one or more skin conditioning or skin treatment functions. Compositions containing a hydrophilic liquid carrier component containing a reflective particulate with thickened and dispersed charge may contain a hydrophobic phase resulting in an emulsion of the emulsion. Compositions having both hydrophilic and hydrophobic phases are also described below.

2. Polymerizable Thickener

The composition of the present invention also contains a polymerizable thickener. The polymeric thickener comprises from about 0.01 to about 10 weight percent of the composition, preferably from about 0.1 to about 5 weight percent, more preferably from about 0.25 to about 3 weight percent. The polymerizable thickener serves to increase the viscosity of the hydrophilic liquid carrier to help disperse or suspend the charged reflective particulate in the hydrophilic liquid carrier. In addition, the polymerizable thickener improves the aesthetics of the composition, such as, for example, good feel, non-lipidity, and easy development.

Examples of thickeners suitable for use in the present compositions are as follows, and thickeners other than those mentioned below may also be used.

A. Carboxylic Acid Polymer

B. Crosslinked Polyacrylate Polymers

C. Polyacrylamide Polymer

D. Polysaccharides

E. Crosslinked Vinyl Ether / Maleic Anhydride Copolymer

F. Crosslinked Poly (N-Vinylpyrrolidone)

3. Natural Anti-inflammatory Ingredients

The compositions of the present invention also essentially contain from about 0.01 to about 10 weight percent of the composition, preferably from about 0.05 to about 8 weight percent, more preferably from about 0.1 to about 5 weight percent of the natural anti-inflammatory component.

Natural anti-inflammatory components can be obtained as extracts that are physically or chemically appropriately extracted from natural sources such as plants, fungi, microbial by-products, and representative examples are candelilla wax, alpha bisabolol, aloe vera, manzistar, gugal, cola Extracts, seaweed extracts, lavender, chamomile, tea tree and the like.

4. Granular material with electric charge

The compositions of the present invention also disperse essentially through about 0.01 to about 10 weight percent of the composition, preferably from about 0.05 to about 3 weight percent, more preferably from about 0.1 to about 1.5 weight percent of thickened hydrophilic carrier. Contains particulate matter with a charged charge. The charged particulate material preferably contains a metal oxide coated with a coating material that allows the net charge to be greater than the zeta potential of the uncoated metal oxide.

Without wishing to be bound by theory, it is believed that reflective granular materials such as TiO ₂ usually have relatively high surface activity, and thus, for example, polymer thickeners cause the previously introduced blending instability. In addition, these particulate matter tends to aggregate, for example, to form agglomerates. This problem can be solved by coating the metal oxide with a coating material that allows the net charge to be greater than the zeta potential of the uncoated reflective particulate material. Typically, the coating imparts at least about −20 or +20 mV (eg, in the positive or negative direction) at a pH of about 4 to about 8.5 or more zeta potentsulol. This provides stability to the formulation and prevents agglomeration of reflective particulates

Preferably, all particulates have a net positive charge or a net negative charge. Since all particulates have the same charge, repulsive forces prevent aggregation and induce a uniform distribution across the hydrophilic phase. As a result, a lower concentration of granular material than (i) can be used to obtain an appropriate skin coverage, (ii) the aesthetics of the composition are increased, and (iii) the instability of the formulation is reduced. Thus, the use of charged particulate material provides an efficient coating in relatively low content of reflective particulate material.

Materials with charges useful in the compositions of the present invention usually have a refractive index of at least about 2, more preferably at least about 2.5, such as from about 2 to about 3.

Preferred particulate materials are those in which the primary particles are in the pure form (ie, pure powder form before bonding with other carriers) in the injector size of about 10 to about 100 nm, more preferably about 15 to about 90 nm. Preferred particulate materials have a major particle size of about 10 to about 600 nm, more preferably about 10 to about 400 nm, even more preferably about 10 to about 100 nm when the composition is dispersed in the composition. Have Primary particle size was measured by instrument by PCS (Photon Correlation Spectroscopy).

The particles can have a variety of shapes such as spherical, spheroidal, elliptical, lamellae, irregular, needle and rod as long as the desired refractive index is provided. The particles can have various physical forms, including rutile, anatase, and combinations thereof.

A. Metal Oxides.

The reflective particulate material preferably comprises TiO ₂ , ZnO, ZrO ₂ and combinations thereof, more preferably TiO ₂ , ZnO and combinations thereof (combination includes particles containing one or more of these materials, and mixtures of these particles). And most preferably essentially TiO ₂ . The granular material is not limited thereto, but may be a composite in which other materials such as silica, silicone resin, mica and nylon are attached on the core or mixed.

Inorganic particulates contain, for example, TiO ₂ , ZnO or ZrO ₂ , are commercially available from various sources, and the compositions may contain other inorganic or organic particulates.

B. Coating Material

The previously described reflective particulate material is preferably coated with a coating material that imparts a higher net charge than the zeta potential of the uncoated reflective particulate material. Thus, a coating can be used that allows the net charge (positive or negative) of the reflective particulate to be greater than the untreated particulate. However, it is advantageous that not all particulates in the composition be treated within the same net charge, such as mixing positive and negative coating materials, so that gains in repulsion between the reflective particulates can be obtained. However, one skilled in the art can use small amounts of coating materials with opposite charges as long as the overall repulsive force is maintained.

Non-limiting examples of coating materials that provide positive charges are cationic polymers (natural and / or synthetic) and cationic surfactants. Preferred cationic coatings include those selected from the group consisting of chitosan, hydroxypropyl chitosan, quaternium-80, polyquaternium-7, and mixtures thereof.

Non-limiting examples of coating materials that provide negative charges are anionic polymers (natural and / or synthetic) and anionic surfactants. Preferred anionic coatings are ammonium polyacrylate, sodium polyacrylate, potassium polyacrylate, ethylene acrylic acid copolymer, hydrolyzed wheat protein polysiloxane copolymer, dimethicone copolyol phosphate, dimethicone copolyol acetate, dimethicone Copolyol laurate, dimethicone copolyol stearate, dimethicone copolyol behenate, dimethicone copolyol isostearate, dimethicone copolyol hydroxystearate, phosphate esters, sodium chondroiton sulfate, sodium hyaluronate , Ammonium hyaluronate, sodium alginate, ammonium alginate, ammonium laurate, sodium laurate, potassium laurate, ammonium myristate, sodium myristate, potassium myristate, ammonium palmitate, sodium palmitate, potassium palmitate, cancer Titanium stearate, sodium stearate, potassium stearate, are selected from ammonium oleate, sodium oleate, potassium oleate, and the group consisting of a mixture thereof.

Charged particulate material (eg treated with a coating material) is available in essentially pure powder form or in a pre-dispersed form in various types of carriers, which may include water, lower monohydric alcohols (eg C _1). -C ₄ ) and organic hydrophilic diluents such as low molecular weight glycols and polyols such as propylene glycol, polyethylene glycol (eg molecular weight 200-600 g / mol), polypropylene glycol (eg molecular weight 425-2025 g / mol), glycerol , Butylene glycol, 1,2,4-butanetriol, sorbitol ester, 1,2,6-hexanetriol, ethanol, isopropanol, sorbitol ester, butanediol, ether propanol, ethoxylated ether, propoxylated ether and its Combinations, but are not limited to such. Preferably, the charged particulate material is previously dispersed in water, glycerin and mixtures thereof.

5. Optional Ingredient

In the present invention, specified above

In addition to the four main classes of components of 'hydrophilic liquid carriers, polymeric thickeners, natural anti-inflammatory components, reflective particulates having an average net particle size charge of about 10 nm to about 100 nm', other compositions suitable for the purposes of the present invention The classification of representative components which may be contained simultaneously and which may be further contained are as follows.

Skin protection and actives

The present invention may contain one or more skin protection and active agents in a proportion of 0.1% to 10% by weight of the total composition, and representative skin protection and active agents include niacinamide, retinol, retinal, retinyl palmitate, retinyl pro Cationate, ascorbic acid, tocophenols and derivatives, and mixtures thereof. Skin protection and active agents are useful for helping to regenerate and protect the skin from skin damage caused by harmful environments such as skin aging and UV irradiation.

Whitening ingredients

The present invention may contain one or more skin whitening components in a proportion of 0.1% to 10% by weight of the total composition, and representative skin whitening components include a mulberry extract, licorice extract, kojic acid, arbutin, ascorbic acid and derivatives thereof Group consisting of mixtures;

Sunscreen

The present invention may contain one or more sunscreen ingredients in a proportion of 0.5% to 10% by weight of the total composition, and representative sunscreens include dioxybenzene, methylanthranilate, benzophenone-4, octylsalicylate, Triethanolamine salicylate, synoxate, oxybenzone, octocrylene, digaloyltrioleate, paradimethyl benzoic acid amyl, diethanolamine paramethoxycinnamate, octylmethoxycinnamate, paraaminobenzoic acid, glyceryl pava , Ethyldihydroxypropyl pava, octyldimethylpaba, 2-phenylbenzoimidazole-5-sulfonic acid, homosalate, drometrizole, butylmethoxydibenzoylmethane, octyltrizone, 3- (4-methyl Benzylidene) -campa and the like.

The exact amount of sunscreen or sunscreen agent used will vary depending on the sunscreen chosen and the desired sun protection index (SPF).

6. Product form

As discussed in the heading ″ Hydrophilic Liquid Carrier ″, the type of carrier used in the present invention depends on the type of product form desired for the composition. However, the product form must utilize at least one hydrophilic liquid carrier or phase. Representative examples of product forms that may be formulated with the compositions of the present invention include lotions and creams, cleansing compositions, and foundations. These product forms are also described as follows.

As mentioned, the topical compositions of the present invention, which are not limited to lotions and creams, may contain dermatologically acceptable hydrophobic ingredients. A wide range of suitable hydrophobic components are known and can be used herein. See Sagarin, Cosmetics, Science and Technology, 2nd edition, Vol. 1, pp 32-43 (1972), include various examples of materials suitable as hydrophobic components.

Lotions and creams according to the present invention generally contain a solution carrier system and one or more hydrophobic ingredients. Lotions typically range from about 1% to about 20%, preferably from about 2% to about 10% of a hydrophobic component; And from about 50% to about 90%, preferably from about 60% to about 80% of water. Creams typically contain from about 2% to about 50%, preferably from about 3% to about 20% hydrophobic component; And about 45% to about 85%, preferably about 50% to about 75% of water.

The present invention useful as a cleansing composition is formulated with a suitable carrier, for example as described above, and preferably contains a safe effective amount of one or more dermatologically acceptable surfactants for cleansing. Preferred compositions contain about 1% to about 90%, more preferably about 5% to about 10% of a dermatologically acceptable surfactant. Surfactants are suitably selected from anionic, cationic, nonionic, zwitterionic, amphoteric and ampholytic surfactants, and mixtures of these surfactants. Such surfactants are well known to those skilled in the cleaning arts. Non-limiting examples of possible surfactants include isocetate-20, sodium methyl cocoyl taurate, sodium methyl oleoyl taurate, sodium lauryl sulfate, and the like. The cleaning composition may optionally contain other materials conventionally used in the cleaning composition at a level where technology is proven.

The physical form of the cleaning composition is not critical. The composition can be formulated, for example, as a liquid, shampoo, bath gel, paste, or mousse. A cleansing composition, such as a shampoo, which is desired to be rinsed away includes a suitable delivery system so that a sufficient level of active agent is deposited on the skin and scalp.

As used herein, the term ″ foundation ″ refers to liquid, semi-liquid, or semi-solid skin cosmetics including but not limited to lotions, creams, gels, pastes, and the like. Foundations are typically used on entire areas of the skin, such as the face, to provide a distinctive appearance. Foundation is typically used to provide an attachment base for color cosmetics such as rouge, cheek paper, and the like and conceal and soften skin defects in the appearance of the skin as well. The foundation of the present invention includes a dermatologically acceptable carrier for the essential particulate material and may include conventional ingredients such as oils, colorants, pigments, emollients, fragrances, waxes, stabilizers and the like.

Compositions of the present invention are generally prepared by conventional methods, such as those known in the art for preparing topical compositions. Such methods typically involve mixing components in a relatively uniform state in one or more steps with or without performing such as heating, cooling, vacuum application, and the like.

Typically, one or more of the components described above may be mixed with the charged particulate material in any order via conventional methods. The resulting mixture is then adjusted to the desired pH range of about 4 to about 8.5. Preferably, the components are first mixed together in any order. The charged particulate material is then adjusted to the desired pH range of about 4 to about 8.5 and then added to the mixture.

7. Coverage Efficiency Ratio

The composition of the present invention has a coating efficiency ratio of greater than about 50, preferably greater than about 60, more preferably greater than about 70. The coating efficiency ratio is calculated as follows:

Coating efficiency ratio = (coating index) / (weight% of reflective particulate material)

For example, a composition containing TiO ₂ with a charge of 0.4% and having a coating index of 15 will deliver a coating efficiency ratio of 37.5.

Determination of the coating index includes measuring light transmittance through the collagen film. The light transmission read from the control collagen film (eg, the film without product) is compared with the light transmission read from the collagen film with the product. The coverage index is then calculated as follows:

Cover Index = [(Control Average-Test Product Average) / Control Average] X 100

The cover index methodology requires a computer with a sufficiently powerful light source for sample illumination, a camera for capturing images of the sample on the collagen surface, and video imaging software for data analysis and viewing on a video frame grabber and video monitor. Suitable image viewing and analysis software includes Optimas 5.2 (Optimas Corp., manufactured by Washington (see Image Analysis Softmare giude Volume I)), the software and guides of which are incorporated herein by reference. Minimal differences can be performed on data using Fischer's LSD method. Protogols describing methods, procedures, and instrument settings for obtaining coverage indices are provided in Examples 1-4 and Comparative Examples 1-2.

8. How to adjust your skin condition

The compositions of the present invention may be used for the skin conditions of mammals, including visible and / or tactile inhomogeneities of the skin, for example, visible and / or tactile inhomogeneities of skin tissues, in particular heterogeneity associated with more skin aging (especially human skin, more specifically It is useful for the regulation of human facial skin.

A wide range of amounts of the compositions of the present invention can be used to provide skin appearance and / or feel benefits. The amount of composition of the invention (mg composition / cm ² skin) typically used per application is from about 0.1 mg / cm ² to about 10 mg / cm ² . A particularly useful dosage is about 1.5 mg / cm ² . Typical applications are about once a day, but the application rate may vary from about once per week to about three times per day.

The composition of the present invention essentially provides a visual improvement in skin condition immediately upon application of the composition to the skin. This immediate improvement includes the covering or masking of skin defects such as tissue heterogeneity (including those associated with skin aging such as enlarged pores).

In a preferred embodiment, the composition comprises an active agent that chronically regulates skin condition and is chronically applied locally. `` Chronic topical application '' and the like may be used over an extended period of time during a subject's life, preferably for a period of at least about 1 week, more preferably at least about 1 month, more preferably at least about 3 months, even more preferably Comprises continuous topical application of the composition for at least about 6 months, and more preferably for at least about 1 year. Chronic control of skin condition involves improvement of skin condition after multiple local application of the composition to the skin. After use for various maximum periods (eg 5 years, 10 years or 20 years), benefits can be obtained, but chronic continuous application throughout the life of the subject is desirable. Typically the application can be applied about once a day over this extended period, but the application rate is about once a week to about three times a day or more. Skin condition control involves topically applying a safe effective amount of a composition of the present invention to the skin. The amount of applied composition, frequency of application, and duration of use will vary widely depending on, for example, the level of skin aging present in the subject and the additional rate of skin aging given the activity level and desired level of control of a given composition.

Control of skin condition may include a composition in the form of skins, lotions, creams, or cosmetics (i.e., `` remaining '' compositions) that will remain on the skin until skin cleansing is adequate for aesthetic, prophylactic, therapeutic or other benefit. It is preferable to carry out by application. After applying the composition to the skin, preferably for a period of at least about 15 minutes, more preferably at least about 30 minutes, more preferably at least about 1 hour, most preferably at least several hours, for example about 12 Leave on skin for less than an hour.

The following examples describe and demonstrate in more detail embodiments that are within the scope of the present invention. The examples are illustrative only and not intended to limit the invention, and many modifications are possible without departing from the spirit and scope of the invention.

Examples 1-4 and Comparative Examples 1-2

Skin anti-inflammatory protection and skin appearance enhancing compositions are prepared from the following ingredients using conventional formulation techniques of emulsions.

water to 100 ¹ to 100 to 100 to 100 to 100 to 100 Disodium EDTA 0.10 0.10 0.10 0.10 0.10 0.10 Carbopol 954 0.50 0.50 0.50 0.50 0.50 0.50 Sorbitan Monostearate / Sucrose Cocoate 1.00 1.00 1.00 1.00 1.00 1.00 1.33 1.33 1.33 1.33 1.33 1.33 Sugar fatty acid ester ² 0.67 0.67 0.67 0.67 0.67 0.67 Isohexadecane 4.00 4.00 4.00 4.00 4.00 4.00 Cetyl alcohol 0.72 0.72 0.72 0.72 0.72 0.72 PEG-100 Stearate 0.11 0.11 0.11 0.11 0.11 0.11 TiO ₂ (charge of average net particle size of 300 nm) - - - - 0.8 - NaOH 0.30 0.25 0.25 0.25 0.25 0.25 water 6.00 6.00 6.00 6.00 6.00 6.00 BGW35MPTAP ³ 0.4 - - 0.4 - - BGW35SAAP ⁴ - 0.4 - - - 0.4 WBG60MPTAMP ⁵ - - 0.4 - - - glycerin 7.00 7.00 7.00 7.00 7.00 7.00 water 5.00 5.00 5.00 5.00 5.00 5.00 Dexpanthenol 0.50 0.50 0.50 0.50 0.50 0.50 Niacinamide 2.00 2.00 2.00 2.00 2.00 2.00 Imidazolidinylurea 0.05 0.05 0.05 0.05 0.05 0.05 Dimethicone 2.00 2.00 2.00 2.00 2.00 2.00 Alpha-bisabolol 0.30 0.30 0.20 0.50 0.50 - Aloe vera 0.20 - 0.10 - - - Chamomile - 0.20 0.20 - - -

¹ . Represents the water component of phase A, the sum of all components of all other phases except the water component of phase A minus 100, that is, the water component of phase A = 100 − (sum of all components of other phases)

² . C1-C30 monoesters or polyesters of sugars and one or more carboxylic acid moieties as described herein, preferably having a degree of esterification of 7-8 and fatty acid moieties being C18 mono- and / or di-substituted and behenic Sucrose polyesters having a molar ratio of unsaturated: behenic 1: 7 to 3: 5, more preferably octaester of sucrose with about 7 Behen fatty acid moieties and about 1 oleic acid moiety, For example sucrose esters of cottonseed fatty acids, for example SEFA cotonates.

³ . Predispersion of TiO ₂ Treated Butylene Glycol, Water, Ammonium Polyacrylate, Alumina, Silica

⁴ . Predispersion of TiO ₂ Treated Butylene Glycol, Water, Ammonium Polyacrylate, Alumina, Silica

⁵ . Predispersion of TiO ₂ treated water, butylene glycol, silica, aluminum, aminomethylpropanol.

For Examples 1-4 above and 1-2 for comparison: First, Phase A components in a suitable sized container are mixed (using a propeller type mixer) and heated to 65-80 ° C. Mix phase B components in separate vessel and heat to 65-80 ° C. Add phase B to phase A while continuing mixing at 60-75 ° C. Thereafter, phase C is added to the batch mixture of phases A / B with continued mixing. Phase C component neutralizes the mixture. In a separate container, phase D is mixed until uniform and then added to the batch mixture of phases A / B / C with continued mixing. Cool to 50 ° C. The phase E components are mixed until homogeneous and then added to the batch mixture of phases A-D with continued mixing. Phase F component is then added to the batch mixture of A-E and then cooled to about 35 ° C. Mixing continues until the resulting batch mixture is homogeneous.

Following the phases A-F, the batch mixture is cooled to about 35 ° C., the phase G components are mixed in a separate vessel and combined into the batch mixture of cooled phases A-F. Mixing is continued until the resulting batch mixture is homogeneous.

Each composition obtained in Examples 1-4 and Comparative Examples 1-2 was applied to the subject's facial skin at a ratio of 1.5 mg composition / cm ² skin, thereby essentially providing immediate visual improvement in skin appearance, e.g., pores, The visibility of wrinkles, lines and wounds is reduced and gives a softer skin tone. In addition, anti-inflammatory action shows heat erythema, ultraviolet erythema, skin microbial inhibitory effect, and helps to soothe wounded and sensitive skin and improve skin surface tissue.

Coating efficiency ratio: The coating efficiency ratio of the composition from Examples 1-4 and Comparative Examples 1-2 shows a value larger than 50. The values of the coating efficiency ratios of Examples 1-4 and Comparative Examples 1-2 were calculated and shown in the following table.

Anti-inflammatory effect: Regarding the anti-inflammatory effect of the compositions from Examples 1-4 and Comparative Examples 1-2, the capillary blood flow reduction value, which is related to the heat erythema sedative effect, the capillary blood circulation associated with the ultraviolet-induced erythema sedative effect Reduction values, microbial reduction rate related to the inhibitory effect on the skin supernatant microorganisms are shown in the table below.

Coating resin 60.2 57.5 58.7 65.1 28.2 56.2 TiO ₂ level (% composition) 0.4 0.4 0.4 0.4 0.8 0.4 Cover efficiency ratio 150.5 143.75 146.75 162.75 35.25 140.5 0.72 0.67 0.85 0.77 0.65 0.07 (mW / cm. ℃) 0.69 0.75 0.85 0.71 0.71 0.03 Skin Overgrowth Microbial Reduction Rate (%) 72.3 85.2 80.8 79.1 78.5 0.7

For the coating efficiency ratio showing immediate visual improvement effect on the skin appearance in the above chart, the compositions obtained in Examples 1-4 and Comparative Example 2, each containing a reflecting material with charge, exhibit a coating efficiency ratio greater than 50. . In contrast, the composition obtained from Comparative Example 1 that does not include a reflecting material with a charge shows a coating efficiency ratio of 50 or less.

The value of the cover index is obtained by the following process:

40 μl of material (Microman M50 pipette) using a collagen film having an exposed surface area of about 7 cm ² (eg IMS # 1192 or equivalent available from IMS Inc. Milford Ct.) Installed in a suitable holder Apply 10 times with your finger and spread evenly with your hands on the film surface. Optionally, the sample is placed on a Zeiss SV-11 microscope (or equivalent) equipped with an IX lens (the microscope is useful for enlarging images captured by the camera; the effective magnification of such systems is about 5 microns / pixel). .). Mounting templates can be used to aid in the repositioning of samples for multiple measurements. The SV 11 is mounted so that the highest light can be delivered to the camera (eg Sony 760-MD CCD 3 camera). In order to preserve proper placement and clear images, the apparatus is installed in the following manner. Camera adjustments are made so that the gamma and linear matrix switches are off. Installation of the camera control box is described in more detail in the following: Gain = 0, white / black balance is Auto, Aperture-Auto, Mode-Auto, Detail-12 o'clock position, Top-0 degree, SC-3 o'clock. Position, H-12 o'clock position, chromaticity diagram-3200K, shut off. The camera may warm up for 15 minutes before adjusting the white and black balance. Press the button marked ″ white ″ to adjust the white balance, pull the black adjustment rod, and push the black button to adjust the black balance. The computer cable connects to RGB1 and composite Sync.ports on the camera. The microscope's aperture is fully open and the frosted glass plate is placed at the bottom of the microscope to even out the light. Transparent glass plates can be used to increase the sample height. Open the Optimus 5.2 program on your computer. To adjust the gain and offset (brightness), use a sample cup that partially covers the optical path with black tape. The reflector at the bottom of the microscope is installed to give the best reflection from the microscope. The average of the light sources is 245-254.5. STD deviation is less than 3. If the average is outside the specification, review the photovoltaic array and mirror adjustment.

As a control, an untreated portion of the collagen film (eg, IMS # 1192 available from IMS Inc. Milford Ct.) Is placed on a sample cup placed on top of a microscope in which the film lies in the center of the optical path. Image capture and analysis software is used to focus the film and measure the light transmission through the film. Multiple measurements are handled in the sample's separation area and the film is repositioned and refocused for each measurement (7 or more measurements are handled). Histogram mean and standard deviation are measured using image capture and analysis software.

To measure the light transmission by the test material, the collagen film having a surface area of about 7 cm ² is first pre-hydrated with distilled water to give flexibility. 40 μl of test material is applied onto the film (eg using a Microman M50 pipette or equivalent) and flattened onto the surface (typically, clean latex pinking to produce a flat film covering the surface of collagen). Lightly spread the material by rotating it 10 times with a coated finger). After 5 minutes, the sample is installed at the bottom of the microscope. Measurement of light transmission through the film and the material is carried out by the method described above for the above control. The least significant differences were obtained using Fisher's LSD method.

The coating index was calculated as follows.

Coating Index = (Control Average-Test Material Average) / Control Average × 100

Control Mean: Average light transmission for reading untreated collagen film

* Test Material Average: Average light transmission to read processed collagen film

In order to evaluate the inflammatory effect of the present invention, the composition of Examples 1-4 and Comparative Examples 1-2 was measured in volunteers, and an in vivo experiment was conducted to measure the effect obtained by the actual consumer. . In order to measure the sedative effect of different inflammation depending on the type of stimulus applied to the skin, the erythema caused by overexposure to infrared light and the actinic erythema caused by overexposure to ultraviolet light and the inhibition of skin microorganisms The effect of the composition of the present invention was tested. Volunteers were divided into a panel of five women aged 22-59 years old and a panel of one male and four women aged 18-29 years old.

Inflammation sedative effect by anti-inflammatory effect was counted by measuring Cutaneous microcirculation, skin erythema and skin temperature. Subcutaneous capillary blood flow was measured by a thermal conductivity measuring instrument (Hematron), which decreased as the capillary contracted and increased as it expanded. The decrease in inflammation is an indication that the swelling (edema) will not go away due to the contraction of the swollen capillaries. Skin erythema was measured using a Minolta CR300 chromameter and skin temperature was also measured using hematron.

IR Phillips 250 S was used to induce heat erythema. The intensity of irradiation was 70mW / ㎠, which was irradiated at a distance of 50cm for 30 minutes to induce heat erythema. The irradiation site was 14 cm 2. Ultraviolet radiation was irradiated to 4 cm 2 site at 100W intensity using a UV irradiation apparatus (SUNTEST / ORIGINAL HANAU) equipped with a Xenon lamp. Minimal Erythemal Dose (MED) for each volunteer was determined and investigated. The soothing effect by the composition of the present invention was measured 24 hours after irradiation with ultraviolet light.

Inhibition effect of the skin microorganism was tested using the cream composition of the present invention. The inhibition test for the microorganisms of the cream composition was used as follows. 10 subjects were subjected to the compositions of Examples 1-4 and Comparative Examples 1-2 on arbitrary areas of the face, and microbial distribution was examined before and after 2 hours of application to each composition. At this time, the area before and after application was 1cm * 1cm, respectively, and the distance before and after application was 1cm or less.

Using sterile cotton, wipe off both before and after application of each composition, and put it into sterile distilled water and stir vigorously for about 3 minutes. 100 μl of the stirred solution was collected and plated on Tryptic soy agar medium, and then cultured at 37 ° C. for 24 hours, and the number of colonies formed was measured. Differences in the number of colonies were able to determine the percentage of skin supernatant microbial inhibition for each composition before and after application.

Heat erythema calming effect

As a result of measuring the average value of capillary blood circulation reduction for 10 volunteers for each of the compositions of Examples 1-4 and Comparative Examples 1-2, the reduction of capillary blood circulation in Examples 1-4 and Comparative Example 1 was measured. Tolerance of heat erythema by the composition of the present invention was excellent, as the value appeared to be at least 0.65 mW / cm. For reference, the thermal conductivity difference (ΔT) is at a level that is reliable if it is 0.1 mW / cm.

In the case of Comparative Example 2, the decrease in capillary blood flow was 0.07 mW / cm.degree. C., so that the thermal conductivity difference (ΔT), which is a confidence level of the effect, was lower than 0.1 mW / cm.

UV-induced erythema sedative effect

As a result of measuring the average value of capillary blood circulation reduction for 10 volunteers for each of the compositions of Examples 1-4 and Comparative Examples 1-2, the reduction of capillary blood circulation in Examples 1-4 and Comparative Example 1 was measured. Tolerance of the UV-induced erythema sedation effect by the composition of the present invention was excellent, as the value appeared to be at least 0.69 mW / cm. For reference, the thermal conductivity difference (ΔT) is more than 0.1 mW / cm. ℃ reliable level.

In the case of Comparative Example 2, the decrease in capillary blood circulation was 0.03 mW / cm.degree. C., so that the thermal conductivity difference (ΔT), which is a confidence level of the effect, was lower than 0.1 mW / cm.

Inhibitory effect on skin microorganisms

As a result of measuring the skin supernatant microbial inhibition rate (%) for 10 volunteers for each of the compositions of Examples 1-4 and Comparative Examples 1-2, the skin supermicrobial inhibition rate in Examples 1-4 and Comparative Example 1 was measured. It was shown that (%) was at least 72.3% or more, and the skin microbial inhibitory effect by the composition of the present invention was excellent.

In Comparative Example 2, the skin supernatant microbial inhibition rate (%) was 0.7%, indicating little effect on the skin microorganisms.

In Examples 1 to 4, the values of the coating index and the coating efficiency ratio, the heat erythema sedation effect, the ultraviolet-induced erythema sedation effect, and the microbial inhibition rate were all effective. Although the numerical value was shown, in Comparative Example 1, the coating efficiency ratio was 35.28, which is 50 or less, and the immediate visual improvement effect of the skin appearance was insignificant, and in Comparative Example 2, the anti-inflammatory effect was insufficient.

It will be apparent to those skilled in the art that various changes and modifications can be made without departing from the present invention by describing the individual embodiments through the embodiments of the present invention. All modifications outside the scope of the invention will be protected within the scope of the appended claims.

The compositions of the present invention assist in anti-inflammatory, soothing, and regenerating skin irritation after skin imperfections, such as redness, acne, UV exposure, irritated skin after laser skin care, and at the same time good in irritated and unbalanced skin tone. By presenting a topical composition that maintains a natural skin appearance while providing a coating, it can be used as a composition having a skin anti-inflammatory effect applicable to various skin problems and a skin appearance enhancement function at the same time.

Claims (7)

A skin protection composition which provides an immediate visual enhancement and anti-inflammatory effect of skin appearance upon topical application of skin, comprising the following composition: (A) about 1 to about 99.98% by weight of the hydrophilic liquid carrier (B) about 0.01 to about 10 weight percent of a polymerizable thickener in the composition (C) about 0.01 to about 10 weight percent of the natural anti-inflammatory component of the composition (D) a reflective particulate having an electrical charge of an average net particle size of from about 0.01 to about 10 weight percent of the composition, from about 10 nm to about 100 nm, The charged particulate material is dispersed throughout the thickened hydrophilic liquid carrier and the composition provides a coverage efficiency ratio of at least about 50. The composition of claim 1, wherein the charged reflective particulate material contains a metal oxide coated with a coating material that imparts a net charge greater than the zeta potential of the uncoated metal oxide. The method of claim 1, wherein the natural anti-inflammatory component can be obtained as an extract physically or chemically appropriately extracted from natural sources such as plants, fungi, microbial by-products, candelilla wax, alpha bisabolol, aloe vera, Manzistar, It includes gugal, cola extract, seaweed extract, lavender, chamomile, tea tree and the like. The polymerizable thickener of claim 1 wherein the polymerizable thickener is a carboxylic acid polymer, a crosslinked polyacrylate polymer, a polyacrylamide polymer, an acrylate / C10-C30 alkyl acrylate crosspolymer, a crosslinked alkyl vinyl ether and a maleic anhydride copolymer. , Crosslinked poly (N-vinylpyrrolidone), polysaccharides and mixtures thereof. The method according to any one of claims 1 to 4, wherein the at least one dermatologically active agent is niacinamide, retinol, retinal, retinyl palmitate, retinyl propionate in a proportion of 0.1% to 10% by weight of the total composition. , Ascorbic acid, tocophenols and derivatives and mixtures thereof. The method according to any one of claims 1 to 5, wherein at least one skin lightening ingredient is used in the proportion of 0.1% to 10% by weight of the total composition of the bark extract, licorice extract, kojic acid, arbutin, ascorbic acid and derivatives thereof Compositions selected from the group consisting of mixtures The method of claim 1, wherein the at least one sunscreen component is dioxybenzene, methylanthranilate, benzophenone-4, octylsalicylate in a proportion of 0.5% to 10.0% by weight of the total composition. , Triethanolamine salicylate, synoxate, oxybenzone, octocrylene, digaloyltrioleate, paradimethyl benzoic acid amyl, diethanolamine paramethoxycinnamate, octylmethoxycinnamate, paraaminobenzoic acid, glyceryl Pava, ethyldihydroxypropyl pava, octyldimethylmethyl, 2-phenylbenzoimidazole-5-sulfonic acid, homosalate, drometrizole, butylmethoxydibenzoylmethane, octyltrizone, 3- (4- Composition selected from the group consisting of methylbenzylidene) -campa and mixtures thereof