KR20030079190A - A Tonic Composition for Complementation of Nutrition for Pregnant Woman Using Natural Food - Google Patents

Abstract

PURPOSE: Provided is a health food supplement for providing pregnant women and nursing mothers with nutrients using raw grain foods, thereby increasing pregnancy rates and improving fetal nutrition. CONSTITUTION: A health food supplement for providing pregnant women and nursing mothers with nutrients is characterized by containing: at least one selected from the group consisting of unpolished rice powder, soy bean powder, glutinous millet powder, buck wheat powder, Glycine max (L.) Merr powder, whole meal powder, red bean powder, and wheat powder; at least one selected from the group consisting of sea tangle powder, com powder, carrot powder, pumpkin powder, Arctium Lappa powder, lotus root powder, Cassia tora L. powder, Artemisia capillaris Thunb powder, crystallized fructose, Angelica Utilis Makino powder, kale powder, pine needle, persimmon leaf, sea lettuce and Lycium chinense Mill; and at least one selected from the group consisting of folic acid, whey calcium, iron phosphate, zinc oxide, DHA-YP, taurine, soy bean lecithin, Rubus suavissimus S. Lee extract, sea slug powder and unpolished rice embryo.

Description

A Tonic Composition for Complementation of Nutrition for Pregnant Woman Using Natural Food}

The present invention is a nutritional supplement dietary supplement for pregnant women and pregnant women, and more specifically, nutritional supplements for improving the nutritional status of fertility women, pregnant women and the fetus using a variety of raw materials and in particular to improve the learning ability of the fetus It is about food.

As the dietary life becomes more westernized and the living environment changes, various adult diseases are emerging as a social problem. Recently, as the demand of consumers to rely on food to prevent and treat such diseases is increasing, interest in raw food products is increasing. The market size is increasing rapidly.

Reproduction has been used as a diet for practitioners since ancient times, and has been reported to have various effects. As such, various effects of reproduction are expected, and recently, reproduction is emerging as one of the new healthy foods.

On the other hand, the maternal nutritional status of pregnancy and lactation is known to directly and indirectly affect the growth and development of the pups as well as the health of the mother. Poor nutrition of the mother is known to affect the nutritional status of the brain. For example, the lack of w-3 fatty acids in the mother during pregnancy has been pointed out that it can affect the retina and its function of the fetus and it is reported that the learning ability may be reduced.

In addition, the dietary precautions of pregnant women should avoid eating unbalanced foods and eating well-balanced foods, especially foods high in calcium and iron, which are likely to be insufficient for pregnant women, and constipation during pregnancy. Therefore, it is recommended to eat a proper amount of foods high in fiber as well as nutritional aspects.

However, there have been no discussions and studies on the effects on the expectant mother and the fetus, especially on the fetal learning ability, despite the above advantages of reproduction.

The inventors pay attention to the above facts and conducted animal experiments using nutritional supplements for fertility women and pregnant women, and found that it is very effective in terms of fertility, growth and learning ability of young rats when ingested into female rats. The present invention has been completed.

Therefore, an object of the present invention is to provide a nutritional supplement dietary supplement for pregnant women and pregnant women containing a variety of raw materials useful for the human body as an active ingredient.

1 is a graph of the change in weight during the breeding period of the female rats.

2 is a graph of weight change during breeding of young mice.

Figure 3 is a graph of weight change during breeding of young mice in the case of applying a labyrinth.

Figure 4 is a graph showing the effect of nutritional supplements on the number of false positives to reach the target in the complex maze.

5 is a graph showing the effect of nutrition supplements on the time required to reach the target in the complex maze.

The present invention is a dietary supplement health supplement food of fertility women and pregnant women,

It includes powders of cereals and legumes, various vegetable powders, nutritional supplements and dietary supplements for fertile women and pregnant women characterized by containing inorganic and organic nutrients as active ingredients.

The powder of cereals and legumes may include at least one selected from the group consisting of brown rice powder, soybean powder, green tea powder, buckwheat powder, weak soybean powder, botanical powder, red bean powder, frosted powder, and wheat powder. Can and

Various vegetable powders include kelp powder, corn powder, carrot powder, pumpkin powder, burdock powder, lotus root powder, gnarly powder, pumpkin flavor powder, jinjin mugwort powder, fructose sugar, fresh herb powder, kale powder, pine needles, persimmon leaf, green seaweed, and wolfberry. At least one selected from the group consisting of powder may be included,

Inorganic and organic nutrients may include at least one selected from the group consisting of folic acid, whey calcium, iron phosphate, zinc oxide, DHA-YP, taurine, soy lecithin, sialoli, cucurbita extract, sea cucumber powder, and brown rice embryos. have.

In addition, the present invention may further include at least one or more selected from roasted black rice, roasted brown rice, and roasted white rice in addition to the powder of cereals and legumes, various vegetable powders, and inorganic and organic nutrients.

Each of the above components is a raw material that can be easily encountered in real life, and the present invention is the first example in which each of the above components is suggested as a use for improving the effects on pregnant women and the fetus, in particular, the fetal learning ability.

The amount of each component added is not particularly limited. However, a preferred embodiment that can be presented as a result of the experiment of the present invention includes all of the components shown above,

Brown rice powder 20 ~ 82.0489% by weight, soybean powder 1-10% by weight, tea powder 0.5-10% by weight, buckwheat powder 0.5-10% by weight, weak soybean powder 0.5-10% by weight, algae powder 0.5-10% by weight, red bean powder 0.1 to 10% by weight, frost powder 0.1 to 10% by weight, wheat powder 0.1 to 10% by weight, pine needles 0.1 to 10% by weight, kelp powder 0.1 to 10% by weight, persimmon leaf 0.1 to 5% by weight, green seaweed 0.01 to 5% %, Wolfberry 0.01-5%, corn powder 0.1-10%, carrot powder 0.1-10%, pumpkin powder 0.5-10%, burdock powder 0.1-10%, lotus root powder 0.1-10%, 0.1 to 10% by weight of powder, 0.1 to 10% by weight of pumpkin flavor, 0.1 to 10% by weight of phosphorus mugwort powder, 0.5 to 10% by weight of fructose, 0.5 to 10% by weight of fresh grass powder, 0.1 to 10% by weight of kale powder, folic acid 0.0001 0.1 wt% to 0.1 wt% whey calcium, 0.1-10 wt% iron phosphate, 0.001-0.1 wt% zinc oxide, 0.1-10 wt% DHA-YP, 0.01-10 wt% taurine, 0.1-10 wt% soy lecithin % By weight, Sialoli 0.01 to 10% by weight, black pepper Can contain 0.01 to 10% by weight, 0.5 to 10% by weight of roasted black rice, 5 to 20% by weight of roasted brown rice, 5 to 20% by weight of roasted white rice, 0.1 to 10% by weight of sea cucumber powder, 1 to 10% by weight of brown rice germ have.

The use of the composition does not require any particular limitation, and may be mixed with water or other beverages for drinking and further comprising known additives.

Hereinafter, to demonstrate the effectiveness of the present invention through the evaluation results for the animal experiments using the powder composition formed in the above range. However, the following examples are provided to explain the contents of the present invention, but the scope of the present invention is not limited thereto.

Example 1 Preparation of Raw Food Powder for Nutrition Supplement

The raw material was first washed with 5 times of water, and after removing the foreign matter, the second wash was performed. After removing the moisture from the raw materials, each raw material was selected as 30 mesh or less which is easy to drink, and then brown rice powder 30.13% by weight, soybean powder 7.21% by weight, green tea powder 1.44% by weight, buckwheat powder 1.44% by weight, and weak bean powder 1.44 Weight%, Algae powder 1.44%, Red bean powder 0.72%, Frost powder 0.72%, Wheat powder 0.72%, Pine needles 0.72%, Kelp powder 0.72%, Persimmon leaf 0.22%, Green seaweed 0.07%, Wolfberry 0.07% by weight, corn powder 2.16% by weight, carrot powder 0.72% by weight, pumpkin powder 2.88% by weight, burdock powder 0.36% by weight, lotus root powder 0.36% by weight, bladder powder 0.22% by weight, pumpkin flavor 1.44% by weight, jinjin wormwood powder 0.36 Wt%, fructose 5.32 wt%, fresh sheath powder 1.44 wt%, kale powder 0.72 wt%, folic acid 0.01 wt%, whey calcium 5.13 wt%, iron phosphate 0.51 wt%, zinc oxide 0.02 wt%, DHA-YP 2.86 wt% , Taurine 0.10% by weight, Soy Lecithin 0.50%, Sialoli 0.20% by weight, Stem extract 0.13% by weight To prepare a functional raw powder, roasted black rice 2.0% by weight, roasted brown rice 10.0% by weight, roasted white rice 10.0% by weight, sea cucumber powder 0.50% by weight, brown rice embryo 5.0% by weight.

Example 2 Breeding, mating and reason of experimental animals

Experiment process

The experimental animals were purchased from Biolink Co., Ltd. for 4 weeks old males and females, and used for experiments after being adapted to the environment for 1 week. Experimental diet was prepared according to the AIN-76 dietary composition as shown in Table 1, and the experimental group of the present invention was prepared by replacing the raw powder by 25% by weight instead of corn starch of the control group.

Table 1 Composition of Experimental Diet

Control Nutritional Supplement 25% Casein 20 20 Corn oil 5 5 Mineral mix 3.5 3.5 Vitamin mix One One Choline chloride 0.2 0.2 Methionine 0.3 0.3 Cellulose 5 5 Sucrose 15 15 Corn starch 50 25 Nutrition 0 25

The female rats adapted to the environment were divided into two groups, the control group and the 25% dietary supplement group, according to the egg mass method, and each diet was fed freely. During the breeding period, dietary intake was measured every other day and body weight was measured once a week. Male rats were also fed a general solid feed. After three weeks of breeding, three females and one male were placed in a cage for mating. One week later, females and females were separated, and female rats were separated into one for each cage, and were fed while continuing to supply an experimental diet. After about three weeks of mating, labor began and the sex and birth weight of the pups were measured. After that, the pups were restricted to 10 rats and the rest were killed. From the 12th day of birth, the body developmental status such as exophthalmism, eye opening, tooth protrusion, and pulp formation was assessed.

Experiment result

(1) change in body weight, delivery rate, and delivery status

Figure 1 shows the change in body weight during the breeding period of the rats fed the dietary supplement group and the control group according to the present invention. The initial weights of the control and dietary supplementation groups were 137.8g and 137.9g, respectively, 3 weeks later (just before mating) and 186.3g and 185.8g, respectively. However, after 2 weeks of mating (5 weeks after breeding), 251.8g of the normal group and 256.6g of the dietary supplement group began to appear about 5g higher. This is due to the fact that the nutritional supplement group has a higher pregnancy rate compared to the control group, resulting in an increase in weight due to pregnancy.

The effects of nutritional supplementation on the labor rate and labor status of rats are shown in Tables 2 and 3 below. First of all, the number of births in the control group was 11 out of 30, and the 25% dietary supplement group delivered 22 of 30. In the delivery rate, the control group was 36.7%. Was 73.7%, which was twice as high as that of the control group. From the fact that the male rats were fed the normal diet group and the nutrient supplement diet was provided only to the female rats, it was judged that the nutrient diet increased the fertility of the female rats and increased the pregnancy and delivery rate. In terms of delivery status, the number of pups delivered per mother was between 9 and 17, and on average, the nutritional supplement group was higher than the control group. Sex ratio was the ratio of females when males were 1, and the sex ratios of male and female were 1: 0.96 and 1: 1.17, respectively. The birth weight was 0.1g lower in the nutrient diet group than in the control group, but compared to the weaning weights after 3 weeks, the control group was 42.3g, which was 45.4g higher than the control group. In addition, the appearance of the mice showed no abnormalities in both the control group and the dietary supplement group.

<Table 2> Effect of Nutritional Supplementation on Delivery Rate in Rats

Breeding head (n) Delivery head (n) Childbirth rate (%) Control 30 11 36.7 Nutritional Supplements 30 22 73.3

<Table 3> Effect of Nutritional Supplementation on Delivery Status in Rats

Delivery head Sex ratio (♂: ♀) Birth weight (g) Weaning weight (g) Control 12.6 ± 1.86 1: 1 6.45 ± 0.25 42.3 ± 1.86 Nutritional Supplements 13.2 ± 0.92 1: 1.05 6.31 ± 0.13 45.4 ± 2.15

(2) physical development

Table 4 shows the effects of nutritional supplementation on the physical development of babies born. At 12 and 14 days of age, the morphological changes of the organs were investigated mainly in the external ear, eye, tooth and tooth formation, and the control and nutritional supplementation groups showed almost the same level. The procedure was successful and all were judged good.

<Table 4> Effects of Nutritional Supplementation on Body Development in Rats

Control Nutritional Supplement 12 days after birth 15 days after birth 12 days after birth 15 days after birth Extrude 65.2 91.3 64.8 94.8 Open eye - 89.1 - 86.7 Tooth protruding 68.0 91.5 70.2 92.9 Hair formation 54 100 52 100

* Unit:% (100% of total number of live births in each group)

Example 3 Measurement of Ovarian Function and Sex Hormones in Mother Rats

Experiment process

The mother rats weaning the pups were reared for four more weeks with each experimental diet, and then analyzed and dissected ovarian function to extract blood and extract organs. Serum was isolated from the collected blood and each organ was trimmed and weighed.

Progesterone and estradiol, progesterone, were analyzed by radioimmuno assay and blood lipid content was analyzed by using each test kit.

Experiment result

(1) change in long-term weight

The organ weights of the rats after 4 weeks of feeding and dissection were shown in Table 5. At the time of dissection, the weight of both groups was about 265g and there was no difference between the two groups.

<Table 5> Effect of Nutritional Supplementation on Organ Weight in Mothers

Treatment group Body weight and organ weight (g) Slaughter weight liver kidney spleen ovary contrast 265.0 ± 16.9 8.03 ± 0.69 0.92 ± 0.06 0.64 ± 0.05 0.048 ± 0.015 Nutritional Supplements 265.4 ± 22.9 7.96 ± 1.04 0.92 ± 0.11 0.63 ± 0.13 0.047 ± 0.011

(2) Ovarian Function and Sex Hormone Concentration

Ovarian function and sex hormone concentrations of mother rats are shown in Table 6. The follicle repeats its growth according to the estrous cycle. The follicle number measured in this experiment is the follicle count per mother, which is 28.6 follicles per control rat, compared to 36.6 nutrient replenishment groups. The nutritional supplementation group was significantly higher.

The corpus luteum occurs in the site of follicular rupture during ovulation. The number of luteal luteal rats was 19.8 in the control group, compared to 36.6 in the dietary supplement group. In addition to the degeneration of the corpus luteum, the color of the corpus luteum was lost and the number of small white bodies of gray-white was also high in the nutrition supplement group, showing the same tendency as the number of follicles and corpus luteum. The progesterone concentration secreted by ovarian corpus luteum cells was 30.28 ng / ml, which was higher than that of the control group. Follicle hormone is also called estrous hormone (estrogen) because it has the ability to induce estrus, the most physiological activity of these estrogens is estradiol-17β (E ₂ ). In the present experiment, the concentration of follicle hormone was slightly higher in the control group than in the dietary supplement group, unlike the progesterone. In the ovarian function test, 28% of the control group and 60% of the dietary supplementation group showed significant vascular development.

<Table 6> Effects of Nutritional Supplementation on Ovarian Function and Sex Hormones in Mother Rats

Treatment group Ovarian Function and Hormone Concentration Follicle Luteal water White body P ₄ (ng / ml) E ₂ (pg / ml) Control 28.6 ± 17.0 19.8 ± 2.9 12.3 ± 6.5 23.2 ± 8.96 38.9 ± 7.81 Nutritional Supplement 36.6 ± 13.5 36.6 ± 13.5 16.8 ± 4.8 30.8 ± 9.71 32.5 ± 8.22

Corpus albicans: The body becomes a scar tissue by replacing it with fibrous connective tissue during the degeneration and contraction of the corpus luteum.

P ₄ : progesterone

E ₂ : estradiol-17β

(3) Serum lipid concentration

The mothers were reared for 4 weeks after weaning, and the change in serum lipid content is shown in Table 7 below. There was no difference in triglyceride and cholesterol contents between the two groups.

<Table 7> Effects of Nutritional Supplementation on Serum Lipids and Blood Glucose in Mother Rats

Treatment group Concentration (mg / dl) triglyceride total cholesterol HDL cholesterol Control 39.7 ± 18.1 115.1 ± 10.3 76.1 ± 4.9 Nutritional Supplement 40.7 ± 24.0 113.6 ± 15.2 74.8 ± 10.4

Example 4 Evaluation of the Effect of Nutritional Supplementation on Growth and Learning Ability of Young Rats

Experiment process

(1) Laboratory Animals and Diet

Males of each of the experimental groups were used for the evaluation of learning ability for the reason of males. In other words, the control group was a young rat from a mother fed with a basic diet, and the young rat from a mother fed with a dietary supplement was a dietary supplement group. The diet of the young mice was fed the basic diet of Example 2 (AIN-76 diet).

(2) Evaluation test for learning ability using maze

The learning ability of young rats was reared for 3 weeks and then tested with Sumi. Sumiro was adapted from the dated maze and applied to the compounded maze. The dated maze was adapted to 10 times using a single-shaped maze, and a mixed maze was applied after 1 week. The number of trials and errors was measured for the swimming time from the departure point to the arrival time. Trial and error measured the number of times rats hit the wall without pointing.

(2) Blood and major organ extraction

After 1 week (10 weeks of age), the rice was fasted for 12 hours, and then opened under ether anesthesia, blood was collected from the abdominal aorta, and major organs such as liver, kidney, and spleen were extracted. Blood was centrifuged at 2500 rpm for 10 minutes to separate serum, and each organ was washed in physiological saline cold solution, trimming, and then weighed by removing water from the surface with filter paper.

(3) Serum GOT, GPT and Lipid Content Analysis

Serum GOT, GPT activity and lipid content were analyzed in the same manner as in Example 3.

Experiment result

(1) Changes in weight and dietary intake during breeding

Changes in body weight, dietary intake, and dietary efficiency of rats applied to the experiments are shown in Table 8 and FIG. The initial weight of rats applied to Sumi was higher than that of the control group on average 3g, but the weight and weight gain after breeding were significantly lower than those of the control group.

The dietary intake was also lower in the nutritionally supplemented diet group than in the control group, but there was no difference in dietary efficiency between the two groups.

In this regard, the low weight gain in the dietary supplement group in the late breeding period may be due to the low dietary intake.

<Table 8> Changes in Weight Gain, Dietary Intake, and Dietary Efficiency

Initial BW (g) Final BW (g) Weight gain (g) Total dietintake (g) FER Apply with Sumi Control 46.5 ± 1.36 292.3 ± 5.96 247.3 ± 6.41 840.2 ± 23.38 0.30 ± 0.01 Nutritional Supplements 49.7 ± 2.92 ^* 269.0 ± 23.56 ^* 215.4 ± 20.55 ^* 674.6 ± 45.80 0.30 ± 0.01

(2) weight of major organs and length of femur

As shown in Table 9, the effect of dietary diet on the weight of major organs tended to be lower in the 25% group of the dietary diet than the control group.

Kidney and spleen weights were not affected by dietary supplementation. The femoral weight and length were not significantly different depending on the dietary supplementation.

<Table 9> Major organ weight and length of femur

Liver (g) Kidney (g) Spleen (g) Femur (g) Thigh length (mm) Apply with Sumi Control 8.91 ± 0.27 1.95 ± 0.21 0.68 ± 0.03 0.83 ± 0.04 34.98 ± 0.36 Nutritional Supplements 7.89 ± 0.39 1.80 ± 0.19 0.64 ± 0.05 0.86 ± 0.03 35.01 ± 0.47

(3) Effect of nutritional diet on learning ability

After feeding the dietary supplements to the rats, the swimming time and the number of misreactions in various mazes are shown in Figures 4 and 5. Using the date maze, the swimming time during the swimming test was significantly reduced in the dietary supplement group compared to the control group.

In the labyrinth, the time taken to pass the labyrinth was 57.2 seconds for the control group in the 7th week of breeding, and there was no difference between the two groups. At the 8th week of breeding, the control group was 65.01 seconds, while the nutritional supplementation group was 53.5. There was no statistically significant difference, but the nutritional supplementation group showed lower values. At 9 weeks of breeding, the control group was 66.9 seconds, while the nutritional supplementation group was 31.4 seconds, and the swimming time was shortened to less than half of the control group. In 10 weeks of breeding, there was a similar tendency to 9 weeks, and the swimming time was significantly shortened by the complex diet in the nutrition supplement group compared to the control group. In addition, the swimming time was shorter in later stages compared to the early stage of the maze swimming test, and the shortening width was larger in the nutrition supplement group than the control group.

5 shows the total number of false positives from the start of the maze to the evacuation scaffold as the destination. In the case of misreacted water, both groups showed a decrease in the number of false positives gradually toward the end of the test compared to the beginning of the labyrinth test, and the decrease was more remarkable in the nutrition supplement group than the control group. Especially, at the 3rd week of the swimming test, the control group decreased slightly compared to 2 weeks, whereas the nutritional supplementation group decreased about 70%, and the number of incorrect reactions in the control group was 10.7 and 3.42 in the nutritional supplementation group. Decreased. At 4 weeks of gestation, the control group decreased about 40% compared to 3 weeks, and the dietary diet group maintained the value of 3 weeks. Comparing the two groups, the nutritional supplementation group also showed a significantly lower value than the control group, and it was determined that the nutritional supplementation significantly reduced the number of false positives.

These results suggest that the nutritional supplementation group showed a better learning ability than the control group. In experiments, the experiment animal is required to recognize many alternative reactions and direction recognition to the target point during swimming, and this experiment is used to recognize the sequence sequence memory of the left and right selective reactions or the direction to the target point. The spatial awareness of the surroundings can be assessed, but it is imperative that it can be a habitual memory assessment rather than an intrinsic memory.

(4) Effect of nutritional diet on blood lipid content

Table 10 shows the effects of nutritional supplementation on blood GOT, GPT activity and triglyceride and cholesterol content in blood. GOT and GPT activity, known as indicators of liver function, did not show any difference between the control group and the dietary supplement group. There was no significant difference between the two groups in blood triglyceride and total cholesterol contents.

<Table 10> Effect of Nutritional Supplementation on Blood GOT, GPT Activity and Lipid Content

GOT (Karmen) GPT (Karmen) Triglycerides (mg / dl) Cholesterol (mg / dl) Apply with Sumi Control 106.25 ± 4.65 31.38 ± 1.16 71.17 ± 5.19 89.56 ± 4.07 Nutritional Supplements 110.38 ± 6.50 35.42 ± 5.32 84.25 ± 13.09 90..35 ± 15.23

According to the present invention, as a result of animal experiments, the pregnancy rate, delivery status, physical development, learning ability of young mice, etc. can be confirmed that the reproductive powder of the present invention is improved nutritional status of fertility women, pregnant women and the fetus, and especially fetal learning. It may serve as a dietary supplement for nutritional improvement.

Claims (4)

In the dietary supplement dietary supplement foods of reproductive women and pregnant women, Nutritional supplement food for women of childbearing and pregnant women, characterized in that it contains grain and soybean powder, various vegetable powders, and inorganic and organic nutrients as active ingredients The method of claim 1, The powder of cereals and legumes may include at least one selected from the group consisting of brown rice powder, soybean powder, green tea powder, buckwheat powder, weak soybean powder, botanical powder, red bean powder, frosted powder, and wheat powder. Can and Various vegetable powders include kelp powder, corn powder, carrot powder, pumpkin powder, burdock powder, lotus root powder, gnarly powder, pumpkin flavor powder, jinjin mugwort powder, fructose sugar, fresh herb powder, kale powder, pine needles, persimmon leaf, green seaweed, and wolfberry. At least one selected from the group consisting of powder may be included, Inorganic and organic nutrients include at least one selected from the group consisting of folic acid, whey calcium, iron phosphate, zinc oxide, DHA-YP, taurine, soy lecithin, sialoli, custard extract, sea cucumber powder, and brown rice germ as active ingredients. Dietary supplement dietary supplement for pregnant women and pregnant women The method of claim 1, Supplementary nutritional supplements for pregnant women and pregnant women, characterized in that it further contains at least one or more selected from roasted black rice, roasted brown rice, roasted white rice The method of claim 1, Brown rice powder 20 ~ 82.0489% by weight, soybean powder 1-10% by weight, tea powder 0.5-10% by weight, buckwheat powder 0.5-10% by weight, weak soybean powder 0.5-10% by weight, algae powder 0.5-10% by weight, red bean powder 0.1 to 10% by weight, frost powder 0.1 to 10% by weight, wheat powder 0.1 to 10% by weight, pine needles 0.1 to 10% by weight, kelp powder 0.1 to 10% by weight, persimmon leaf 0.1 to 5% by weight, green seaweed 0.01 to 5% %, Wolfberry 0.01-5%, corn powder 0.1-10%, carrot powder 0.1-10%, pumpkin powder 0.5-10%, burdock powder 0.1-10%, lotus root powder 0.1-10%, 0.1 to 10% by weight of powder, 0.1 to 10% by weight of pumpkin flavor, 0.1 to 10% by weight of phosphorus mugwort powder, 0.5 to 10% by weight of fructose, 0.5 to 10% by weight of fresh grass powder, 0.1 to 10% by weight of kale powder, folic acid 0.0001 0.1 wt% to 0.1 wt% whey calcium, 0.1-10 wt% iron phosphate, 0.001-0.1 wt% zinc oxide, 0.1-10 wt% DHA-YP, 0.01-10 wt% taurine, 0.1-10 wt% soy lecithin % By weight, Sialoli 0.01 to 10% by weight, black pepper 0.01-10% by weight, 0.5-10% by weight of roasted black rice, 5-20% by weight of roasted brown rice, 5-20% by weight of roasted white rice, 0.1-10% by weight of sea cucumber powder, 1-10% by weight of brown rice germ as active ingredients Dietary supplement dietary supplement for pregnant women and pregnant women