KR20030021869A - The impurities removal method for the herbal medicine solution - Google Patents

Abstract

PURPOSE: A method of removing agricultural chemicals and remaining heavy metals contained in an extract and juice of natural drugs through a filtering apparatus, and fine starch particles contained therein by precipitating in a solvent and then removing the solvent with a reduced pressure distillation method. Therefore, the product permits long-term storage when vacuum packed by inhibition of growth of putrefactive bacteria and has enhanced clarity. CONSTITUTION: An extract and juice of natural drugs is passed through a ball filtering apparatus to remove suspended solids, agricultural chemicals and remaining heavy metals, added with 30 to 50%(v/v) of an organic solvent such as ethanol, normal hexane, ether, agitated for 1hr and then precipitated for 24hr. Thereafter, the supernatant is treated with a phenol-H2SO4 method to give a starch content of 0.1ppm or less and then distilled at 50 to 60deg.C under reduced pressure of 300 to 600mmHg.

Description

The method of removing the fine starch granules, pesticides and heavy metal residues contained in the hot water extract (tanger) or juice of herbal medicines {The impurities removal method for the herbal medicine solution}

The present invention relates to a method for removing fine starch granules, pesticides, and heavy metal residues contained in hot water extracts (flours) or juice of medicinal herbs.

Herbal medicine has various prescriptions, broad efficacy, and physiological natural healing power. However, in the case of hot water extract prepared by hot water extraction, it is largely taken in one dose, and it is difficult to manufacture and distribute in large quantities due to bitter taste. Because of this, the herbal medicine manufacturers are producing in the form of granules or pills, but in order to eliminate the bitter taste, the excessive effect of excipients (lactose), etc., is difficult to maintain the quality of the drug.

In addition, the conventional method for removing impurities such as fine starch granules uses centrifugal separation or filtration, but in the case of Chinese medicine prescription, it is commercialized in pharmaceutical process due to the change of the drug efficacy due to the over or under extraction of the active ingredient of the herbal medicine and the cost burden. There was a problem that could not be, and centrifugation and filtration were difficult to remove the pesticides and heavy metal residues.

In the present invention, the pesticides and heavy metal residues mixed in the medicinal herbs (solution) made by adding herbal medicines to water were removed through a filtration device, and the fine starch granules were not dissolved in organic solvents (ethanol, normal hexane, and ether). The solvent was precipitated by addition of 30-50% (V / V), and then the supernatant was removed to remove the organic solvent by distillation under reduced pressure to obtain a final product in which suspended solids such as fine starch granules were completely removed.

1 shows a sequence of the present invention

Hot water extract or juice of herbal medicine contains starch granule, water soluble protein, fiber, tannin and polyphenol compound. When the storage period elapses, they react with each other to form white or dark green brown precipitates, which not only have a poor taste, but also have a high possibility of deterioration, thereby degrading the value of the product.

Therefore, in the past, as the preservative is added or sterilized at a high temperature, not only the inherent flavor but also active ingredients are decomposed and lost. The present invention is a method of insolubilizing these starch granules and the like using an organic solvent to completely remove even fine particles. In addition, the added organic solvent can be removed by the vacuum distillation method. In this way, the precipitated starch granules and the extracts from which the organic solvents are removed may not be suspended in the form of suspended solids or precipitates, and thus may be stored for a long time.

Herbal medicine has various prescriptions, a wide range of efficacy, and physiological natural healing powers. However, in the case of a hot water extract prepared by boiling water extraction, it is difficult to manufacture and distribute in large quantities due to one-time use and bitter taste. For this reason, herbal medicine manufacturers are manufactured with siblings such as granules or pills, but due to excessive addition of excipients (lactose, etc.) to eliminate the bitter taste, it is difficult to maintain the quality and maintain the quality. By solving this problem of extracting herbal ingredients and removing fine starch granules, which are difficulties in the manufacture of herbal medicines, the mass production and cheap distribution of herbal medicines or health supplements, greatly improving national health and medical development. Will contribute.

The following describes the operation of the present invention.

Herbal herbal medicines are decocted in boiling water to obtain extracts or pressurized juices. This extract (or juice) is removed from the primary suspended solids, pesticides and heavy metal residues through a filtration device of 2mm water treatment ball.

The following is the result of XRF measurement of ball component for water treatment.

* Experimental data 1: XRF measurement result of ball component for water treatment in filtration system

-Analytical Institution: Basic Science Support Institute Busan Branch

Date of measurement: April 24, 2001

Metric / Sample Name Sample Al ₂ O ₃ 13.847 SiO ₂ 69.953 MgO 1.023 K ₂ O 2.173 CaO 0.503 TiO ₂ 0.983 Fe ₂ O ₃ 6.760 MnO 0.162 Na ₂ O 1.006 ZrO ₃ 0.039 P ₂ O ₅ 0.001 or less L.O.I. 0.162

* Experimental Data 2: Comparison of Water Quality between Treated Water and Raw Water Using Water Treatment Ball

As a result of comparing water quality of treated water and raw water by using ball for water treatment, raw water of 43 items including lead component was inadequate in chromaticity of 10 degrees among water quality standards, but it was found to be suitable for 1 degree in treated water. Nitrate, hardness, potassium permanganate consumption, evaporation residue, and turbidity also decreased, while 1.1-dichloroethylene and iron were increased, but there was no problem in drinking water standards. In most of the other items, both samples were not detected.

-Institution: Environmental Biotechnology Research Institute

Date of measurement: April 21, 2001

* Experimental Data 3: Analysis of Reduction of Pesticide Components by Using Ball for Water Treatment

-Analytical Institution: Korea Testing Institute

Date of measurement: January 12, 1999

Pesticide Ingredients unit Before treatment After treatment Test Methods Diazinon ppm 0.96 0.35 GC Chlorotinoin ppm 0.99 0.22

* Experiment 4: Analysis of Heavy Metal Reduction by Water Ball

-Institution: Gyeongsang National University Institute of Plant Horticulture

Date of measurement: September 18, 1998

heavy metal unit Before treatment After treatment Test Methods As ppm 216.90 71.62 I.C.P. Hg ppm 39.93 30.62 Pb ppm 2.03 1.77 Cr ppm 1.04 0.58 Ni ppm 28.98 10.08

30-50% (v / v) of organic solvent was added to the extract which passed through the filter, stirred for 1 hour, and then precipitated for 24 hours. The concentration of organic solvent is determined by the degree of impurities in the extract, but in the case of ordinary extract, 30% is sufficient, and when it is 39% or less, the precipitation rate may drop. On the other hand, if the filtrate is large, it should be added up to 50%. If more than this is added, the filtration efficiency is high, but the consumption of organic solvents increases, which is economical.

Discard the sediment and take only the supernatant. Use phenol-H ₂ SO ₄ to quantify the starch and make the starch content less than 0.1 ppm.

The pressure is adjusted to 300mmHg-600mmHg to remove the organic solvent (ethanol, normal hexane, ether, etc.) contained in the supernatant. Then, since the b.p of the organic solvent is less than 60 ℃ and easily volatilized, the result is usually obtained after 3 hours of treatment. This technique is generalized as a method of removing volatilization of organic solvents.

It can be stored for a long time during vacuum packaging due to the inhibition of growth of decaying microorganisms due to the removal of starch, mass production and distribution without the addition of preservatives, water molecules are activated and body absorption is facilitated by the removal of starch. Even a small amount of the effect can be maintained. In addition, since starch particles have been removed, transparency can be improved and a high quality product can be obtained.

Claims (1)

Extract the decoction or pressurized juice from herbal medicines by boiling water method, Removing the first suspended matter, pesticides and heavy metal residues through the filtration device of the 2mm water treatment ball in the filtration device, An organic solvent (ethanol, normal hexane, ether) is optionally added to the extract through the filtration device 30% -50% (v / v) and stirred for 1 hour and then precipitated for 24 hours, Discard the precipitate, take only the supernatant, quantify the starch by phenol-H ₂ SO ₄ method to less than 0.1ppm starch content, Characterized in that it comprises a step of producing a final product by distilling under reduced pressure at a pressure of 300mmHg-600mmHg at 50 ℃ -60 ℃ to remove the organic solvent contained in the supernatant, Method for removing fine starch granules, pesticides and heavy metal residues contained in hot water extract (tanger) or juice of herbal medicines.