KR20020089279A - undecylenic acid solution : CH H2 O2 - Google Patents

undecylenic acid solution : CH H2 O2 Download PDF

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KR20020089279A
KR20020089279A KR1020020068612A KR20020068612A KR20020089279A KR 20020089279 A KR20020089279 A KR 20020089279A KR 1020020068612 A KR1020020068612 A KR 1020020068612A KR 20020068612 A KR20020068612 A KR 20020068612A KR 20020089279 A KR20020089279 A KR 20020089279A
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South Korea
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undecylenic acid
acid solution
skin
water
triethanolamine
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KR1020020068612A
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Korean (ko)
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전상문
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전상문
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/20Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)

Abstract

PURPOSE: An undecylenic acid solution containing undecylenic acid and triethanolamine as a main component is provided which is effective against both Trichophyton and mold, filamentous fungi on skin surface, shoes and rubber gloves without injury to skin. CONSTITUTION: The undecylenic acid solution contains a suitable amount of undecylenic acid, triethanolamine, propyl alcohol, polypropylene glycol, polyethylene glycol, polypropylene glycol, water and the like.

Description

운데실렌산 용액{undecylenic acid solution : CH H2 O2}Undecylenic acid solution {CH H2 O2}

지금까지 나온 의약품으로 무좀약이 연고이고, 피부를 손상시키고 쉽게 치료가 되지 않고 또 사용목적에 따라 신발, 고무장갑, 공용으로 쓰고 있는 목욕탕 저울, 수건등에는 용액으로 살포해야 하므로 기존연고로서는 사용이 불가능하고 치료가 월등한 본 발명품을 사용하고자 하며 저녁만 되면 가려워서 피가 나도록 피부를 긁고 밤잠을 잘 수 없는 사람도 1회만으로도 피부에 소량 바르면 피부손상은 주지 않고 시원하면서 가려움이 없고 잠을 잘 수 있고 3회 정도면 피부에는 아무런 영향을 주지 않고 완치가 됨It is a medicine that has been used so far, athlete's foot is an ointment, and it is not easily cured, and according to the purpose of use, shoes, rubber gloves, common bathroom scales and towels should be sprayed with a solution. If you want to use the invention of the impossible and excellent treatment, even if you can not scratch the skin to bleed and bleed at night in the evening, even if you apply a small amount to the skin with only one time, it does not damage the skin, itching and can sleep 3 times, it heals without affecting the skin

본 발명품에 사용한 약품을 기술적으로 열거하면If we enumerate the drugs used in the present invention technically

운데실렌산(undecylenic acid solution) : MSDS name으로 10-undecylenic acid 이고 화학대사전 page 848에서 상온에서 액체(미황색) 저온에서 고체(백색)인 것도 있고, 땀과 비슷한 특이한 냄새가 있다. 융점 24.5℃, 비등점 275℃, 비중 0.910~0.913, 물에는 거의 녹지 않고 에탄올에만 녹는다. 백선균, 사상균에 대한 치료약.Undecylenic acid solution: The MSDS name is 10-undecylenic acid, which is liquid (light yellow) at room temperature and solid (white) at room temperature, and has a peculiar smell like sweat. Melting point 24.5 ℃, boiling point 275 ℃, specific gravity 0.910 ~ 0.913, almost insoluble in water, only in ethanol. Medications for ringworm, filamentous fungi.

트리에탄올아민(triethanolamine) : (HOCH2CH2)3 화학대사전 461쪽, 화학약품 대사전 919쪽 녹는점이 21℃, 끓는점277℃ 백색으로 흡습성의 액체 또는 고체이고 물을 흡수해 점성이 풍부한 액체로 된다. 물, 알콜에 가용, 중성 비누, 유화중합도료, 양모윤활제, 피혁 유연화제, 표면활성제, 방충첨가제, PH 조절제 중화제 등으로 사용하며 일본촉매화학 미국 Dow chem사 서독 BASF사에서 생산.Triethanolamine: (HOCH2CH2) 3 Page 461, Chemical Metabolism, page 919 Chemical metabolism, page 919 Melting point 21 ° C, boiling point 277 ° C White, hygroscopic liquid or solid, absorbing water to give a viscous liquid. Soluble in water, alcohol, neutral soap, emulsified polymerization paint, wool lubricant, leather softener, surface active agent, insect repellent additive, PH regulator neutralizer etc. Produced by Japan Catalyst Chemical USA Dow chem, West Germany BASF.

프로판올(propyl alcohol) : 화학약품대사전 2495쪽 CH3CH2CH2OHPropanol (propyl alcohol): page 2495, CH3CH2CH2OH

무색 투명한 휘발성액체, 특이한 냄새가 있고, 눈부신 불꽃을 발휘하며 연소한다. 물, 보통의 유기용제와 임의로 혼합하며 용제로 사용It is a colorless transparent volatile liquid, has a peculiar smell, and burns with a dazzling spark. Randomly mixed with water, common organic solvent, used as solvent

프로필렌글리리콜(propylene glycol) 문성명 저 화학약품 대사전 1113쪽,Propylene glycol civilization low chemical metabolism p. 1113,

무색 투명하고, 냄새가 없는 액체 약간 단맛이 있다. 물, 알콜, 아세톤, 클로로포름, 에테르 등과 임의로 혼합된다. 183℃~195℃에 비등, 다른 용제 보다 용해력과 독성이 적다. 용도로서는 계면 활성제(세정제), 화장품원료, 유화안정제, 약국방, 식품첨가제, 의약품, 연초 등의 조습제, 식품에 첨가하면 곰팡이 방지 효과가 향상된다. 한국미원, Dow chem사, Wcc사, 쉘 석유 회사에서 생산Colorless, transparent, odorless liquid with a slightly sweet taste. Optionally mixed with water, alcohol, acetone, chloroform, ether and the like. Boiling at 183 ℃ -195 ℃, less solvent and less toxic than other solvents. Uses include surfactants (cleaners), cosmetic raw materials, emulsifying stabilizers, pharmacy rooms, food additives, medicines, humectants such as tobacco, and food additives to improve the antifungal effect. Produced by Miwon Korea, Dow Chem, Wcc, and Shell Oil Company

폴리에틸렌글리콜(polyethylene glycol) : 화학약품대사전 1106쪽 HO(HC2CH2O)nH 폴리에틸렌글리콜은 점성이 있는 액체 분자량이 200이하를 사용. 물, 많은 유기용제에 용해하고, 자극성이 없어서 화장품, 의약품에 비이온 계면 활성제로 사용. 특히 의학계에서는 연고용 로션, 좌약용에 사용.Polyethylene glycol: page 1106, Chemical Dictionary, HO (HC2CH2O) nH Polyethylene glycol has a viscous liquid molecular weight of 200 or less. Soluble in water, many organic solvents, non-irritating, used as nonionic surfactant in cosmetics and medicines. Especially in the medical field, it is used for ointments and suppositories.

폴리프로필렌글리콜(polypropylene glycol) : 화학약품대사전 1109쪽.Polypropylene glycol: Chemical Metabolism, p. 1109.

무색 점성 있는 액체이고 저분자는 물에 완전히 용해, 알콜에 용해하며 계면활성제로 사용, 흡습제 성질이 강하다.It is a colorless, viscous liquid. Low molecules are completely soluble in water, soluble in alcohol, used as surfactants, and have strong hygroscopic properties.

사람이나 가축 등의 살결 표면의 균상종, 감염균을 박멸시키기 위하여 위에서 열거한 성질을 이용하여 본 발명의 주된 약품인 운데실린산의 독성을 줄이고 알콜, 물에 가용성이 되게 하기 위하여 중화제인 트리에탄올아민으로 적당히 중화하여, 물, 알콜을 용해하고, 점성이 풍부하고 표면 활성제, 방충제로서 사상균, 백선균등을 박멸하게 하며 위에서 코로이드 상태의 액을 물과 프로판올을 첨가하여 맑은 상태의 액으로 전환. 여기에 조습제이며 약국방, 첨가제이고 피부의 표면을 활성화하여 피부밑에 있는 균을 운데실린산이 침투하게 하여 곰팡이 균등을 박멸하게 된다. 프로필렌글리콜 대신 폴리에틸렌글리콜, 혹은 폴리프로필렌글리콜을 사용할 수도 있다.To reduce the toxicity of undecylenic acid, the main drug of the present invention, and to make it soluble in alcohol and water, by using the above-mentioned properties to eradicate fungal species and infectious bacteria on the surface of human or livestock Neutralize moderately, dissolve water and alcohol, rich in viscosity, eradicate filamentous fungi, ringworm, etc. as a surface active agent, insect repellent, and convert the above cooid liquid into clear liquid by adding water and propanol. It is a humectant, pharmacy room, and additive. It activates the surface of the skin to infiltrate the bacteria under the skin, thereby eradicating the fungus. Polyethylene glycol or polypropylene glycol may be used instead of propylene glycol.

본 발명은 지금까지 생산되고 있는 무좀약은 연고이고 피부표면을 부식시켜 피부밑에 서식하는 무좀균을 죽게 하지만 본 발명품은 피부는 절대로 손상시키지 않고 1회 치료만으로도 즉시 가려움이 없어지고 3회 정도 치료하면 완치되고, 용액상태로 분무하여 신발, 고무 장갑, 대중이 사용하는 기구, 동물의 피부 등을 치료하며 사람이나 동물의 눈 가까이는 멀리하고 직사광선을 피하고, 실온에서 보관하여야 한다.In the present invention, the athlete's foot medicine produced so far is an ointment and the surface of the skin is eroded to kill athlete's foot, but the present invention does not damage the skin immediately and the itch is eliminated immediately with only one treatment. It should be sprayed in solution to treat shoes, rubber gloves, equipment used by the public, skin of animals, etc., away from the eyes of people or animals, avoiding direct sunlight, and stored at room temperature.

Claims (1)

운데실렌산과 트리에탄올과의 중화반응 후 물과 프로판올로 희석시켜 용액으로 만들고 곰팡이균을 죽일 수 있고 피부 표면 활성제인 프로필렌글리콜을 사용할 수 있고 프로필렌글리콜 대신 폴리프로필글리콜, 폴리에틸렌글리콜등을 사용할 수도 있으므로 이 범위 전체를 청구범위로 한다.After neutralization reaction between undecylenic acid and triethanol, it can be diluted with water and propanol to make a solution, and it can kill fungi, propylene glycol, which is a skin active agent, and polypropylglycol, polyethylene glycol, etc. can be used instead of propylene glycol. The entirety is set forth in the claims.
KR1020020068612A 2002-11-06 2002-11-06 undecylenic acid solution : CH H2 O2 KR20020089279A (en)

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61257920A (en) * 1985-05-13 1986-11-15 Sato Seiyaku Kk Antimycotic gelatinous agent for external use
KR19990072131A (en) * 1995-12-14 1999-09-27 우에하라 아끼라 Aerosol formulations
EP1031353A1 (en) * 1999-02-24 2000-08-30 Stiefel Research Institute, Inc. Antimycotic compositions
KR100266304B1 (en) * 1992-03-13 2000-09-15 오쓰까 아끼히꼬 Antibacterial and antifungal agent
US6224887B1 (en) * 1998-02-09 2001-05-01 Macrochem Corporation Antifungal nail lacquer and method using same
WO2002007683A1 (en) * 2000-07-24 2002-01-31 Polichem S.A. Antimicotic nail varnish composition

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61257920A (en) * 1985-05-13 1986-11-15 Sato Seiyaku Kk Antimycotic gelatinous agent for external use
KR100266304B1 (en) * 1992-03-13 2000-09-15 오쓰까 아끼히꼬 Antibacterial and antifungal agent
KR19990072131A (en) * 1995-12-14 1999-09-27 우에하라 아끼라 Aerosol formulations
US6224887B1 (en) * 1998-02-09 2001-05-01 Macrochem Corporation Antifungal nail lacquer and method using same
EP1031353A1 (en) * 1999-02-24 2000-08-30 Stiefel Research Institute, Inc. Antimycotic compositions
WO2002007683A1 (en) * 2000-07-24 2002-01-31 Polichem S.A. Antimicotic nail varnish composition

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