KR101796816B1 - Cosmetic composition for protecting skin comprising dimethicone, acrylate, triethanolamine and bromelain - Google Patents

Abstract

The present invention relates to a skin protecting composition containing dimethicone, acrylate, triethanolamine and bromelain as an active ingredient. More specifically, the present invention relates to a composition for skin protection comprising dimethicone, acrylate, triethanolamine and bromelain in addition to purified water, stearic acid, Glycerin, methylparaben, and isopropyl myristate.
According to the present invention, when the cosmetic composition of the present invention is applied to the skin, a thin film is formed on the skin to protect the skin from chemical solvents and solvents, and exhibits excellent moisturizing effect while the film is formed.

Description

[0001] The present invention relates to a skin-protecting composition containing dimethicone, acrylate, triethanolamine and bromelain as an active ingredient,

The present invention relates to a skin protecting composition containing dimethicone, acrylate, triethanolamine and bromelain as an active ingredient. More specifically, the present invention relates to a composition for skin protection comprising dimethicone, acrylate, triethanolamine and bromelain in addition to purified water, stearic acid, Glycerin, methylparaben, and isopropyl myristate.

In the name of functional cosmetics, a lot of functional cosmetics are sold in the cosmetics market. Especially, it is found that it contains many factors of skin destruction contained in air dust due to destruction of ozone layer and environmental pollution caused by industrialization, solvent contained in color make-up in rapidly growing cosmetics market, Our skin (especially hands) is exposed unprotected from housekeeping eczema and skin diseases caused by chemical residual ion concentration, and skin breakdown caused by solvents contained in numerous chemical products in the industrial field. In addition, infections in the secondary environment, working with exposed hands, and splicing of residual chemical ion concentrations, are found to cause countless skin disorders and corresponding problems such as atopic skin, skin eczema, and burns. Therefore, in order to prevent and reduce skin irritation and inflammation caused by such chemical solvents and to reduce adverse effects caused by harmful radicals, etc., which may be caused by the residual ingredients themselves, it is necessary to firstly prevent such harmful elements from passing through the skin There has been a desperate need for the development of products containing anti-solvent, anti-inflammatory and skin irritation mitigating effect through thin film formation on the skin.

Dimethicone, a kind of silicone oil, is a synthetic oil that is not easily altered compared to plant minerals and forms a protective barrier in the skin. Dimethicone is also used as a dry, water-repellent and reduces the oily feel of the lotion, giving it a powdery feel. It is also a lubricant that leaves a soft feel on the skin and does not cause side effects when used in various silicone oils. Cream, lotion, etc. when making a small amount to add to the oil layer makes me feel soft, reduce oil and cause acne is a raw material. In addition, it removes the bubble in the cream to reduce the effect on the skin when applied. It gives a silky feel on the skin, gives a softening effect, is widely used for wound healing, and is used to improve scars.

Acrylate has been in use since 1992 and has been used for cacyimony blanket, military blanket and fiber glues for fibers, fiber treatment agents for reinforcing agents, adhesives and impact modifiers, especially molding resins. It is widely used in film formers, especially moisturizers. The skin is covered with a thin film to make it sticky, give a smooth texture, and form a thin film film to prevent water evaporation and maintain moisture. It is a kind of polymer that forms a thin film. It is used to increase the viscosity of cosmetics and to protect the easily changing effect substances in the air.

Triethanolamine is commonly used as a pH regulator. It has a function to increase foaming property, foam stability and grease solubility, and to prevent and dissolve bubbles in the mixed raw material. It is also weakly alkaline, water-soluble and detergent and is also important as a cosmetic raw material. It does not irritate the skin because it has strong emulsifying power and weak basicity. And has an excellent effect in stabilizing the foam of the surfactant. Triethanolamine is also used to neutralize the lauryl sulfate salt, the active ingredient in liquid shampoos, and this salt is also used as a cosmetic emulsifier. Ethanolamine is used as a raw material for coatings such as resin, lacquer, and paint. Triethanolamine as an additive shortens the solidification time of cement and concrete, shortens the solidification time of cement and concrete according to temperature, and is also used as an additive to prevent the collapse of cement and concrete according to temperature. In the present invention, the cosmetic composition serves to form a film within 60 to 120 seconds after application to the skin.

Bromelain is a protein enzyme extracted from pineapple. It is absorbed into the body and circulates along the blood. It breaks down the protein in the blood, the antibody complex and the unnecessary impurities in the blood and breaks down the allergic hypersensitivity (Protein) that causes the disease is also used to treat allergies and inflammation relief. In addition, the effect of dissolving fibrin in the blood to suppress blood clotting and circulation is good because it prevents stroke, heart attack. In addition, it has been shown to have a vascular cleansing action by decomposing debris on the inner wall of the blood vessel, and it is very effective for phlebitis. It also has the ability to reduce inflammation of the body. Inflammation of the joints During wounds, wounds, bruises, bruises. It has efficacy in treatment of edema, edema and so on. There are three types of bromelain: 600, 1,200 and 2,400 (GDU / g min) depending on the activity. 600 has a weak activity and 2,400 is too strong to rapidly dissolve protein (skin keratin). As a result, the mouth may be torn or weak blood may be seen. In cosmetics in general, a sufficient effect can be obtained with 1,200. In this study, 1,200 is used for sufficient effect. This enzyme has been proven to be effective for anti-inflammatory, anti-edema, anti-thrombotic and lytic effects in both bacterial culture dish experiments and human body experiments. It is harmless to the human body and has no side effects.

Stearic acid is a fatty acid used as a softener. The other ingredients are not damaged in the solvent and each ingredient can maintain its inherent characteristics.

Glycerin is used to moisturize and texture and is stable at high temperatures. It attracts moisture that can maintain the homeostasis of the skin and improves the moisture protection of the skin. Glycerin extracted from vegetables, palm or coconut is a colorless, fragrant sticky syrup. Very volatile and well mixed with water and alcohol. Glycerin is a pure natural substance that helps the skin to contain moisture to soften and smooth the skin and soothe the skin. It is most often used in body care or cosmetics to supply moisture and oxygen to the skin. It also has a healing function as well as a moisturizing function. Glycerin takes water from the bacteria and attacks the bacteria, thus helping the wound to heal quickly. One of the strongest effects of glycerin is also its anti-drying action. The greatest feature of these glycerin is the strong moisturizing and viscosity.

 Methylparaben is a substance found in nature and is often found with other parabens in fruits such as blueberries. It is widely used as a food and cosmetic preservative, and it has been reported that there is no adverse reaction to skin, but allergies can occur when it is eaten, and it may accelerate skin aging and adversely affect DNA when it reacts with ultraviolet light. It also has excellent antibacterial effect.

Isopropyl myristate (IPM) is often used as a thickener and softener. Isopropyl myristate (IPM) is an oily ingredient in cosmetics, which helps to absorb cosmetics. Use within 1 ~ 3% of the total. Very permeable and flexible with moderate odor. It is light and smooth texture, oil-soluble. It is mixed with functional ingredients and spreads widely on the surface of the skin to increase transdermal absorption and protect skin. As a raw material for cosmetics, it is often used as a component that softens and glosses the skin.

We wear rubber gloves and cotton gloves to prevent exposure to chemical poisons in everyday industrial life and daily life. When we demand the efficiency and fineness of work or demand delicacy in work environment, Often, the job is not smooth.

There are some products listed as defensive means for solving the above problems. However, these products are only limited to ultraviolet ray blocking to have a blocking effect, and the effect of chemical poisons on solvents and solvents is not effective. In addition, even products made from ultraviolet screening agents do not have sufficient effect and often can not be blocked. Even if ultraviolet rays are effectively blocked, instability of the ultraviolet screening agent itself causes generation of stimulant substances (harmful radicals) There was a problem.

The inventors of the present invention have made extensive efforts to overcome the problems of the prior art. As a result, the inventors have found that there is a raw material which can form an environment capable of forming a thin film on the skin, which is a barrier for protection of the skin, The present inventors have found that the protective film can form a very strong protective film on the surface of the skin by causing a specific reaction when formulated, and that this protective film can have a very strong protecting effect against the harmful chemical poison.

Therefore, it is a main object of the present invention to provide a skin protective film which comprises dimethicone, acrylate, triethanolamine and bromelain having effective skin protection and moisturizing effect against toxic chemicals corresponding to the acid and chlorine-based disinfectants, And a cosmetic composition for skin protection.

According to one aspect of the present invention, the present invention provides a process for the production of dimethicone comprising 2 to 6% by weight of dimethicone, 1.5 to 5% by weight of acrylate, 1 to 5% by weight of triethanolamine, 0.5 to 3% by weight of bromelain, A cosmetic composition for skin protection, which comprises 2 to 8 wt% of glycerin, 0.5 to 3 wt% of methylparaben, 0.5 to 3 wt% of isopropyl myristate, 0.1 to 1 wt% of polyvinylacetate and 80 to 90 wt% of purified water, to provide.

In order to form a protective film on the skin, the cosmetic ingredients registered in the International Cosmetic Ingredient Dictionary and Handbook of Korea Food and Drug Administration (KFDA) and dimethicone which forms a skin protective film and acryl I found the rate. In addition, we focused on the film-forming effect and the emulsifier effect of the acrylate, and through the optimal fusion environment of the two, the first experiment which can approach the object of the present invention was carried out. However, there was a problem that fine bubbles were generated in the blending of the two raw materials. The presence of bubbles means that there is no smooth combination between dimethicone and acrylate. Bubbles are a phenomenon occurring in the water surface along with boiling when the content of impurities such as oils or soda minerals is high, and triethanolamine is added in order to judge that the efficacy thereof may be fatal. As a result, bubbles are not produced and excellent efficacy is confirmed Respectively. Through these experiments, the present invention was completed using dimethicone, acrylate, triethanolamine and bromelain as core materials.

In the present invention, the composition is characterized in that it has a skin barrier function against toxic chemicals.

According to the experimental examples of the present invention, when the composition of the present invention (Example 1) was applied to the whole hands and then dropped into the hands, it showed a distinctive difference from the comparative examples and showed the protective effect against harmful chemical poisons. From these results, it can be seen that the composition of the present invention can exhibit a defense against harmful chemical toxins by producing a protective film on the skin at a certain mixing ratio (Experimental Example 1 and Figs. 1 to 4).

In the present invention, the toxic chemical is any one selected from the group consisting of chlorine-based disinfectants including acid and chlorine.

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According to the experimental example of the present invention, when the composition of the present invention (Preparation Example 1) was used only in the patient having skin diseases according to the present invention, as shown in FIGS. 8A to 8C, . These results show that the composition of the present invention has a moisturizing effect so that the skin can maintain a sufficient function by forming a protective film on the skin (Experimental Example 3).

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According to the experimental examples of the present invention, it was found that the cosmetic composition of the present invention (Preparation Example 1) was excellent in moisturizing effect in the group used for skin moisturizing for one week, It is found that the composition has excellent moisturizing effect (Experimental Example 2).

In the present invention, the cosmetic composition is stored in an airtight container, first stored for 72 hours at 5 to 8 ° C, then opened for sealing at 35 to 38 ° C for 24 hours, homogenized, .

In addition, in the present invention, the above-mentioned Folic Acid is added to the uppermost layer of all the raw materials after the secondary storage, and then homogenized after being stored for 3 hours for 10 hours.

The state of the pre-homogenizing blend is very important for optimal smooth blending of the composition. For effective mixing, each raw material is stored in a sealed container, kept at 5-8 ° C for 72 hours, kept at 35-38 ° C with the lid of the raw material storage container opened for 24 hours . After all these raw materials have been put in a homogenizing box, drop the fulvic acid into the uppermost layer (the pH of the polybutanic acid should not exceed 1.8 ~ 2.2).

The process of dropping 0.3% Fulvic acid into the top of all raw materials and leaving it for 10 hours before homogenization is very important. It is impossible to cultivate any bacteria while staying in the upper layer of the raw material of the final stage in which the fulvic acid in the pH 1.1.8 to 2.2 state is to be blended. While the fulvic acid remains in the upper layer for 10 hours, all the raw materials in the lower layer are homogenized, And dissolves the state of the raw material so that highly precise stirring can be performed. After 10 hours in this state, it can be seen that a slightly blue-colored ring-like pattern is formed in the upper layer of the raw material. In this state, when the homogenization step is performed, a complete composition having the efficacy of the present invention can be completed.

In the present invention, the cosmetic composition according to the present invention may be used as a skin lotion, a skin softener, a skin toner, an astringent, a lotion, a milk lotion, a moisturizing lotion, a nutrition lotion, a massage cream, A nutritional essence, a pack, a soap, a cleansing foam, a cleansing lotion, a cleansing cream, a body lotion and a body cleanser formulation.

Hereinafter, the effects of the present invention will be described in more detail.

When the cosmetic composition of the present invention is applied to the skin, a thin film is formed on the skin after at least about 60 to at most about 120 seconds. This membrane causes strong resistance to harmful substances such as acids and laxes. It prevents the penetration of chemicals from chemicals, detergents, paints, greases, lubricants, chlorine, solvents, ammonia and corrosive acids and protects them from industrial accidents and housekeeping eczema. I think we can contribute. The film formed in this way is characterized by being kept on the skin for about 4 to 5 hours and not being removed even after washing with soap or other detergent for a sustained period of time. These skin protective films are useful for the treatment of skin loss, light burns and other skin diseases in the industrial field. By maintaining the moisture of the skin during the formation of the membrane, the environment in which the natural treatment can proceed smoothly is maintained. It is possible to remarkably reduce the excessive amount of chemicals.

When the cosmetic composition of the present invention is applied to the skin, a thin film is formed on the skin to protect the skin from chemical solvents and solvents, and exhibits excellent moisturizing effect while the film is formed.

Fig. 1 is a photograph showing the state of the palm after applying the cream of Comparative Example 1 to the hand and dropping the cream into the hand. Fig.
Fig. 2 is a photograph showing the state of the palm after applying the cream of Comparative Example 2 to the hand and dropping the cream into the hand. Fig.
3 is a photograph showing the state of the palm after applying the cream of Comparative Example 3 to the hand and dropping the cream into the hand.
Fig. 4 is a photograph showing the state of the palm after application of the Example 1 to the hand and dropping of the lax into the hand. Fig.
FIG. 5A is a photograph showing a case of applying the cosmetic composition of the present invention, Example 1, to the palm of a hand and applying the same.
5B is a photograph showing a scene in which the user waits for 120 seconds after applying the first embodiment to the hand.
Figure 5c is a scene in which 35% of hydrochloric acid is dropped onto the foil.
FIG. 5D is a photograph showing the state of the palm after dropping 35% hydrochloric acid after 120 seconds from application of Example 1. FIG.
FIG. 5E is a photograph showing a scene in which the hydrochloric acid of the palm sprayed in FIG. 5D is dropped on the bricks again.
6 is a photograph showing the moisturizing effect according to the use of the cream of the present invention.
FIG. 7A is a photograph showing the effect of the cream of the present invention after it is applied to an iron worker who is severely injured by a hand.
FIG. 7B is a photograph showing the effect of the cream of the present invention after correcting the non-diabetic dermatosis patient.
FIG. 7C is a photograph showing the effect of the cream of the present invention after being properly applied to a patient suffering from eczema and skin allergy.

Hereinafter, the present invention will be described in more detail with reference to Examples. These embodiments are only for illustrating the present invention, and thus the scope of the present invention is not construed as being limited by these embodiments.

Comparative Example  One : Dimethicone  Single composition

Dimethicone, a kind of silicone oil, is a synthetic oil that does not easily deteriorate as compared to vegetable minerals, and the general idea of forming a protective film on the skin is already known. However, dimethicone itself did not have the physical effect of protecting the desired chemical poisons. Namely, dimethicone is a kind of silicone oil, and it is well known that when it is applied to the skin, it forms a fine film, but the protective film is a film which protects the skin from moisture evaporation. To confirm these properties, dimethicone (purchased from common cosmetic raw materials and pharmaceutical raw materials) not mixed with other compositions was used alone.

Comparative Example  2 : Dimethicone  And Acrylate  Preparation of mixed composition

10 g of dimethicone and 10 g of acrylate were mixed at a ratio of 1: 1.

Comparative Example  3: Dimethicone , Acrylate  And Triethanolamine  Preparation of mixed composition

In Comparative Example 2, there was a problem that fine bubbles were generated in the process of mixing dimethicone with acrylate (purchased from common cosmetic raw materials and pharmaceutical raw materials). This bubble did not disappear in many ways. Compared with the comparative example 1, a better effect can be proved. However, the fact that bubbles (phenomena occurring in the water surface part together with boiling when the content of bubbles is high in impurities such as oils or soda fractions) This means that these bubbles may be fatal to the efficacy not only in the experimental stage but also in the final combination. In Comparative Example 3, triethanolamine was added and tested.

10 g of dimethicone, 10 g of acrylate and 10 g of triethanolamine were mixed and used in a ratio of 1: 1: 1. In the present invention, triethanolamine having a purity of 98% was used.

In this formulation, the bubbles disappeared and no bubbles were found after the experiment.

The results of the continuous experiments of Comparative Examples 1 to 3 showed the results of the mixing ratio of Example 1, which is the most optimal condition, and are specifically described in the following Example 1.

Example  One : Dimethicone , Acrylate , Triethanolamine  And Bromelain  Preparation of mixed composition

In the production method of Comparative Example 3, only the blend of the central raw material was controlled to complete the present invention. Specifically, 2.8 g of dimethicone, 2.2 g of acrylate, 2 g of triethanolamine and 1 g of bromelain were mixed and used. In the present invention, triethanolamine having a purity of 98% was used.

Formulation Example  1: Manufacture of cream

Examples of formulations of creams in cosmetics containing dimethicone, acrylate, triethanolamine and bromelain are shown in Table 1 below, and the preparation method thereof is as follows.

All the raw materials used in the present invention are the raw materials listed in the Cosmetics Dictionary of the Food and Drug Administration. As a method for the production of the present invention, among the above-mentioned 11 raw materials, especially, dimethicone (dimethicone) as a main component, triethanlamine (triethanolamine) - Acrylates / C10-30 (acrylate) - Bromelai (bromelain) Fusion of a certain ratio serves as the principle of core formulation.

More specifically, the state of the pre-homogenizing blend is very important for the optimal smooth blending of the composition. For effective mixing, each raw material is kept in a sealed space at 5 to 8 ° C for 72 hours, at a temperature of 35 to 38 ° C for 24 hours while the lid of the raw material storage container to be mixed is opened. After all the raw materials are put in the homogenizing box, drop the fulvic acid (0,3%) to the uppermost layer (it should not exceed the pH of 1.8 ~ 2.2). .

It is very important to drop 0.3% of fulvic acid into the uppermost layer of all raw materials and leave it at 35 ~ 38 ℃ for 10 hours before homogenizing. When fulvic acid in the pH range of 1.8 to 2.2 is blended, it is impossible to cultivate any bacteria while the folvic acid is staying in the upper layer of the final stage raw material. During the 10 hours in the upper layer, all the raw materials in the lower layer are homogenized When dissolving, it acts to dissolve the state of the raw material so that highly precise agitation can be achieved.

number Raw material content(%) One Dimethicone 2.8 2 Acrylate 2.2 3 Triethanolamine 2 4 Bromelain One 5 Methyl paraffin One 6 Stearic sheet 2 7 Isopropyl myristate One 8 glycerin 3 9 Paul Vicksan 0.3 10 Purified water 84.7 system 100

Experimental Example  1: skin barrier formation test

The skin barrier formation test was conducted on the examples and comparative examples. Specific methods are as follows. Each experiment carried out the next experiment four days after one step experiment and 50 repetition experiments.

One) Comparative Example  One ( Dimethicone )

Five healthy adult males were treated with dimethicone on their entire hands, and 5 ml of Lax (finial lactose) stock solution was dropped onto the cotton gloves (palm area) with cotton gloves. The result was a very strong and hot reaction in the palm of your hand immediately, and your hand was placed in the ready-made washbasin water. After removing the cotton gloves, dark marks appeared clearly in the palm as shown in Fig. 1, and the burning phenomenon continued for a day.

As shown above, it can be seen that the formation of the protective film of dimethicone itself has no protection against chemical poisons.

2) Comparative Example  2( Dimethicone   And Acrylate )

Five healthy adult males were applied to the entire hand of the composition mixed in Comparative Example 1, and then 5 ml of the crude solution (finial lactose) was dropped on the cotton glove (palm part) with the cotton gloves. As a result, unlike Experiment 1), I did not feel strong heat, but there was a shock-like reaction similar to Experiment 1). Unlike Experiment 1), after holding for 30 seconds without putting hands in the prepared water, the gloves were removed from the reaction such as itching, and hands were put into prepared water. As shown in Fig. 2, only a slight faint reaction point appeared on the palm of the palm.

As shown in the above results, it was confirmed that the composition of 1: 1 mixture of dimethicone and acrylate had a skin protective effect, but it was found that the skin protective film was insufficient and the protective ability against chemical poison was insufficient.

3) Comparative Example  3 ( Dimethicone , Acrylate  And Triethanolamine )

Five healthy adult males were applied to the entire hand of the composition mixed in Comparative Example 2, and 5 ml of the crude solution (finial lactose) was dropped on the cotton gloves (palm area) with the cotton gloves. As a result, as shown in FIG. 3, no stimulation such as irritation and itching was observed at all, and no trouble was observed in the palm after taking off the gloves.

4) Example 1 (dimethicone, acrylate and triethanolamine)

Five healthy adult males were applied to the entire hand of the composition mixed in Comparative Example 2, and 5 ml of the crude solution (finial lactose) was dropped on the cotton gloves (palm area) with the cotton gloves. As a result, as shown in FIG. 4, no reaction such as irritation or itching was observed at all, and no trouble was observed in the palm after taking off the gloves.

After the experiment with the lactose, it was confirmed that no trouble appeared, and the experiment was conducted again with hydrochloric acid in the same manner as described above. The experimental method and results are shown in FIG. 5 (a) to (e). As a result, as shown in Figs. 5 (a) to 5 (e), when 35% hydrochloric acid was dropped on the foil, there was a risk of smoke and tearing of the foil. However, No trouble was shown when I dropped it.

Experimental Example  2 : Skin moisturizing effect  Test

Fifty (10 male, 40 female) of the cream of Preparation Example 1 were tested for facial skin moisturization without using makeup, so that they were used on the face twice a day once every 5 hours. The results are shown in Table 1 below.

condition Number of people After 1 day Two days later 3 days later After 1 week Very good 32 38 38 41 good 15 12 12 9 usually 3 Poor

As a result, as shown in Table 1, the composition of the present invention exhibited more than usual results even when it was used for one day. It was confirmed that the composition of the present invention was excellent in skin moisturizing effect Able to know.

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Experimental Example 3: Additional moisturizing and naturally-occurring test

In this experiment, the patient was directly experimented. The cream of Preparation Example 1 was discontinued for the patient who had 18 skin diseases (patient-centered mainly on the hands and feet), and only the present invention was used. And the results are shown in Table 2 and Figs. 7A to 7C.

condition Number of people 3 days later After 1 week after 2 weeks After 3 weeks Very good 14 15 15 17 good 3 3 3 One usually One Poor

As shown in Table 2, from the first week after the use of the composition of the present invention, more than half of the patients were very good. More specifically, those who had a rapid recovery experienced no symptoms of wounds from two days after the use of the composition of the present invention, Had a very rapid wound treatment effect after 3 days. In particular, one patient proved to have a therapeutic effect of about 70% after 4 to 6 weeks. As a result of combining with the effect of Experimental Example 1, the composition of the present invention has a therapeutic effect, and as a result, it is presumed that sufficient moisturization is maintained so that the skin can naturally grow by forming a perfect protective film on the skin.

As described above, the cosmetic composition of the present invention shows a skin protection effect and a moisturizing effect by producing a thin film on the skin, so that it can be usefully used in industrial fields and homes to reduce damage of harmful chemical substances. It can be also useful as a composition.

Claims (10)

A combination of 2.8% by weight of dimethicone, 2.2% by weight of acrylate, 2% by weight of triethanolamine and 1% by weight of bromelain was mixed with various basic cosmetic compositions (glycerin, methylparaben, isopropyl myristate, And purified water).
The cosmetic composition for skin protection according to claim 1, which has a skin-protecting effect against toxic chemicals corresponding to acid (Acid) and chlorinated disinfectant (lactose) groups containing strong acids.
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