KR20020072600A - Preparation of Microcapsules - Google Patents

Abstract

PURPOSE: A manufacturing method of microcapsules having superior biocompatibility and high manufacturing efficiency is provided. CONSTITUTION: The manufacturing method of microcapsules comprises the steps of preparing a solution in which surfactant is added to a biocompatibility natural polymer solution or natural polymer solution; and manufacturing microcapsules by homogenizing the materials after adding a core material, a coagulant (a wall forming agent), and a solution in which surfactant is dissolved in an organic solvent in certain cases to the surfactant added solution, wherein the biocompatibility capsules are protein such as sodium alginate, chitosan, gelatin, keratin, lipoprotein and fibrin, the core material comprises oil, dyestuff, pigment, incense, foodstuffs, medication, agricultural chemicals, adhesive, lipophilic cosmetics, or skin activating constituents, sodium alginate and chitosan are preferably used as a capsule material, 1 to 8 wt.% of ESPR-25 (polyglycerin polylinoleate, HLB=0.5), ES-7 (glycerin monostearate, HLB=3.8-4.3), SPAN-60 (sorbitan stearate, HLB=6.8-8.6), SE-11 (sucrose fatty acid ester, HLB=11), MP-8, TW-80, TW-20(sorbitan laurate + ethylene oxide, HLB=16) or a mixture thereof depending on HLB values is used as an emulsifier for the total amount of the solution, and a solution of the capsule material is controlled to 0.1 to 5.0 wt.%, and more preferably to 1 to 3 wt.%.

Description

Preparation of Microcapsules {Preparation of Microcapsules}

The present invention relates to a method for producing a microcapsule having a natural polymer membrane which does not affect the environment and the living body, which contains ink, drugs, flavors, pesticides, adhesives, foods, dyes, rust inhibitors, heat storage agents and the like as a core material.

Microencapsulation has been studied in a variety of fields including pressure sensitive recording papers, formulations, fragrances, sustained-release pesticides, adhesives, foods, dyes, solvents, rust inhibitors, liquid crystals and health foods. In particular, a number of techniques have been developed or developed for microencapsulation of hydrophobic materials (oily materials and solid materials). Methods of making microcapsules are described in many literatures. Generally, this is accomplished by the polymer forming the capsule film by interfacial polymerization of monomers (Patent BE-A-808 034, BE-A-839 748, BE-A-869 107, FR-A-2 504). 408, and FR-A-2 515 960), by emulsifying two phases (Patent EP-A-0 274 961, EP-A-557 489, EP-A-0 447 318, And WO 93/25195). Korean Patent Publication No. 98-72 discloses a method of encapsulating lactic acid bacteria in a protective agent, a fat and an emulsifier, and Korean Patent Publication No. 97-700490 discloses an ultrasonography of encapsulating air with a mixture of biodegradable polymers and lipids. A contrast agent is disclosed. Korean Patent Publication No. 95-23330 also illustrates a method for encapsulating polyunsaturated fatty acids using a starch emulsifier.

Accordingly, an object of the present invention is to provide a microcapsule having excellent biocompatibility and high manufacturing efficiency, and a coagulant capable of solidifying the core material and the film-forming material in an organic solvent which can be mixed with a solvent in which the polymer forming the polymer film is dissolved. The present invention relates to a method for preparing microcapsules by adding a solution in which a core material is dissolved in a solution in which a film-forming polymer and a surfactant are dissolved while stirring at high speed.

According to the invention, a solution in which a surfactant is added to a solution of a biocompatible natural polymer or a natural polymer solution is prepared and homogenized by adding a solution in which a core material, a coagulant (wall forming aid) and a surfactant are dissolved in an organic solvent. It is characterized by the preparation method of microcapsules.

In the present invention, the core material may be an oil, a dye, a pigment, a perfume, a food, a medicine, a pesticide, an adhesive, a gluing agent, a lipophilic cosmetic, or an active ingredient for skin.

The capsule material that can be used in the present invention is preferably a natural polymer that is harmless to a living body. Capsule material concentration is an important factor in the yield and storage stability of microcapsules because it affects the strength of the capsule and the ability to retain the nuclear material in the capsule. Therefore, it is preferable to use sodium alginate and chitosan as the wall material.

Emulsifiers include ESPR-25 (polyglycerine polylinoleate, HLB = 0.5), ES-7 (glycerin monostearate, HLB = 3.8-4.3), SPAN-60 (sorbitan stearate, HLB = 6.8-8.6), SE-11 (sucrose fatty acid ester, HLB = 11), MP-8, TW-80, TW-20 (sorbitanlaurate + ethylene oxide, HLB = 16) is preferably used. These emulsifiers may be used alone or in combination of two or more thereof. The emulsifier is added in an amount of 1% to 8% based on the total amount of the solution.

The solution of the capsule material is adjusted to 0.1 to 5.0%, preferably 1% to 3.0% range.

As a solvent capable of dissolving the core material, alcohols such as methanol, ethanol, propanol and isopropanol and ketones such as acetone, ethyl methyl ketone and methyl ethyl ketone are preferably used, and methanol, ethanol and acetone are preferably used.

As a material for the capsule wall formation, a solution such as calcium lactate, calcium carbonate, etc. is particularly used when using sodium alginate as a capsule material, and a solution of NaOH, calcium sulfate, sodium sulfate, and sulfuric acid when chitosan is used. It is desirable to. Crosslinking agents can also be used together.

The size of the microcapsules prepared according to the invention ranges from 0.1 to 30 μm.

Hereinafter, the present invention will be described in detail based on the preferred embodiments, but the scope of the present invention is not limited to these examples.

Example 1

1 g of chitosan was dispersed in 200 g of distilled water in a 1 L round bottom flask at room temperature, and 0.5 g of MP-8, a nonionic surfactant, was added to the aqueous dispersion.

At room temperature, 5 g of caprylic and capric acid triglycerides each containing 10% retinol and 20 g of 2% NaOH solution were dissolved in 200 ml of ethanol in a 500 ml round bottom flask.

The ethanol phase was then added to the aqueous phase with rapid stirring to obtain a colloidal suspension of microcapsules (pH 7.8) having an average diameter of 1.2 μm.

Example 2

10 g of peppermint and 20 g of calcium nitrate 3% solution was dissolved in 100 ml of ethanol in a 200 ml beaker. After dissolving 1 g of sodium alginate in 200 g of distilled water at room temperature, 0.5 g of Twin 80, a nonionic surfactant, was added to the aqueous dispersion.

The ethanol phase was then added to the aqueous phase with rapid stirring to give a colloidal suspension (pH 6.7) of capsules with an average diameter of 2.1 μm.

As is apparent from the above description, the microcapsules prepared according to the present invention are biocompatible and can reduce environmental pollution, and can be widely used in food, medicine, cosmetics, and the like. According to the method of the present invention, there is an advantage that the microcapsules can be manufactured at a low cost and a simple manufacturing process.

Claims (2)

Preparing a solution in which a surfactant is added to a solution of a biocompatible natural polymer or a natural polymer solution and homogenizing the solution by adding a core material and a coagulant (wall forming aid), and optionally a solution in which the surfactant is dissolved in an organic solvent. Method for producing a microcapsule comprising the step of preparing a microcapsule. The method of claim 1, wherein the biocompatible capsule is a protein such as sodium alginate, chitosan and gelatin, keratin, lipid protein, fibrin and the like.