KR20020063893A - Personal care articles comprising a hydrophilic conditioning agent exhibiting a defined leaching value - Google Patents

Abstract

The present invention relates to a substantially dry disposable personal care article comprising: a) a water-insoluble substrate containing a nonwoven layer; b) a therapeutic efficacious composition comprising a hydrophilic conditioning agent exhibiting a leaching value of less than about 25% at 1 minute and less than about 50% at 5 minutes when the article is exposed to water, A therapeutic efficacy component (therapeutic efficacy component) comprising from about 10% to about 1000% by weight of the therapeutic active ingredient, disposed proximate to the water insoluble substrate. Such articles have been found to be particularly useful for personal cleansing applications, i.e., for skin and hair. Accordingly, the present invention also relates to a method of cleansing and / or treating (e.g., conditioning) skin and hair using the article of the present invention.

Description

PERSONAL CARE ARTICLES COMPRISING A HYDROPHILIC CONDITIONING AGENT EXHIBITING A DEFINED LEACHING VALUE < RTI ID = 0.0 > A < / RTI >

Personal care products, particularly cleansing and conditioning products, have been marketed in many forms, such as conventional bar soaps, creams, lotions, and gels. Typically, these products have been tried to meet a number of criteria to be recognized by consumers. These criteria include cleansing effects, skin texture, mildness to the skin, hair and mucous membranes, and the volume of foam. An ideal personal cleanser should gently cleanse the skin or hair, cause little or no irritation, do not leave a lot of detergent buildup on the skin or hair after frequent use, or do not overdry the skin or hair.

It is also highly desirable to deliver such cleansing and conditioning benefits using disposable products. Disposable products are convenient because they do not need to carry or store the cumbersome bottles, bars, pails, tubes and other forms of clutters that contain cleansing products and other products that can provide therapeutic or cosmetic benefits. In addition, the use of a disposable article, such as a sponge, washcloth, or widely-used cleansing tool, may result in undesirable characteristics due to bacterial growth, unpleasant odors, and other repeated use It is more hygienic.

The article of the present invention is surprisingly simple, inexpensive, and provides effective cleansing and / or useful treatment of the skin and hair in a sanitary manner. The present invention provides simplicity that does not require carrying, storing, or using separate tools (such as washcloths or sponges), cleansers, and / or useful therapeutic products. Such articles are easy to use as they are in the form of single disposable personal care articles or multiple disposable articles useful for cleansing as well as for the application of useful therapeutic or cosmetic preparations. The articles are also suitable for use in or with another personal care tool designed for wider use. In this case, the article of the invention is placed in or attached to a separate, non-disposable personal care tool, such as a bath towel or washcloth towel. The disposable article of the present invention can also be detachably attached to a handle or grip suitable for cleansing the article and / or moving it on a surface to be treated (e.g., conditioned).

In preferred embodiments, the article of the present invention is suitable for personal care applications, but can be used for cleansing and / or as an example of a surface or area requiring application of useful materials such as waxes, conditioners, UV protectants, but also in various other industrial fields such as vehicle care, furniture care, animal care, and the like.

In a preferred embodiment of the present invention, the article is suitable for personal care applications and is useful for cleansing and / or conditioning skin, hair and similar keratinous surfaces requiring such treatment. Consumers wet these items with water and use them by rubbing on the area to be treated. The article consists of a water insoluble substrate and a therapeutic efficacy member. Without wishing to be bound by theory, it is believed that the nonwoven layer of the substrate enhances, in particular, cleansing and exfoliation, and optimizes delivery and deposition of useful therapeutic or cosmetic materials that may be contained within the article.

Summary of the Invention

The present invention relates to a substantially dry disposable personal care article comprising:

a) a water-insoluble substrate containing a nonwoven layer:

b) a therapeutic efficacious composition comprising a hydrophilic conditioning agent exhibiting a leaching value of less than about 25% at 1 minute and less than about 50% at 5 minutes when the article is exposed to water, From about 10% to about 1000% by weight, of a therapeutically effective amount disposed proximate to said water-insoluble substrate.

The present invention also relates to a) cleansing and / or conditioning the skin and hair, comprising the steps of: a) wetting the article with water and b) contacting the skin or hair with the moistened article.

All percentages and ratios used herein are by weight unless otherwise indicated and all measurements are made at 25 ° C unless otherwise specified. The invention may, and may consist essentially or entirely of any and all of the elements and members described therein.

In the description of the invention various embodiments and / or individual characteristics are disclosed. As will be apparent to one skilled in the art, any combination of the embodiments and features described above is possible and achieves the preferred practice of the present invention.

All documents referred to herein, including patents, patent applications, and published disclosures, are incorporated herein by reference in their entirety.

The present invention is directed to disposable personal care articles suitable for cleansing and / or therapeutically treating skin, hair, and any other area requiring cleansing and / or therapeutic treatment. The article includes a water insoluble substrate comprising a nonwoven layer and a therapeutic benefit component disposed adjacent the water insoluble substrate wherein the member is a water insoluble substrate, To about 10% to about 1000%, by weight of the composition, of a hydrophilic conditioning agent, wherein when the article is exposed to water, the conditioning agent is less than about 25% per minute, less than about 5% Exhibit leach values of less than 50%.

Consumers use the article by wetting it with water and rubbing the area to be treated (e.g., conditioned) to be cleansed and / or treated therapeutically.

The present invention also includes a method of cleansing and / or conditioning skin and hair using the article of the present invention.

As used herein, the term " disposable " is used in its ordinary sense to refer to an article to be disposed or disposed of after a limited number of uses, preferably less than 25, more preferably less than about 10, most preferably less than about 2, Is used.

As used herein, the expression " substantially dry " means that the article of the present invention has a viscosity of less than about 0.95 gms, preferably less than about 0.75 gms, more preferably less than about 0.5 gms, even more preferably less than about 0.25 gms More preferably less than about 0.15 gms, and most preferably less than about 0.1 gms. Measurement of moisture retention is discussed later.

The personal care article of the present invention contains the following essential ingredients.

Water-insoluble substrate

The article of the present invention comprises a water-insoluble substrate comprising at least one nonwoven layer or ply. Preferably, the nonwoven layer is non-abrasive. As used herein, " non-abrasive " means that the layer has a thickness of greater than about 15, preferably greater than about 30, more preferably greater than about 50, even more preferably greater than about 70, Means the wear value measured by the wear value methodology. Preferably, the base layer is soft and provides vitality to the consumer ' s skin during use.

Without being bound by theory, the water-insoluble substrate improves cleansing and / or therapeutic treatment. The substrate may have the same or different fabrics on each side so that the holding side of the article is the same or different from the skin / part contact surface. The substrate can serve as an efficient foaming and exfoliating tool. By being in physical contact with the skin or hair, the substrate significantly aids in cleansing and removing dust, makeup, dead skin, and other residues. However, in a preferred embodiment, the substrate is non-abrasive or nonabrasive to the skin.

Suitable materials for the nonwoven layer are selected from the group consisting of cellulosic nonwoven, sponges (i.e. both natural and synthetic), molding films, batting, and combinations thereof. Advantageously, said layer comprises a layer of at least one material selected from the group consisting of cellulose nonwoven, formed film, lofty bat, foam, sponge, ≪ / RTI > More preferably, the nonwoven layer comprises a material selected from the group consisting of a cellulose nonwoven, a non-lofty nonwoven, a molded film, a lofty batting, and combinations thereof. As used herein, the term " nonwoven fabric " means that the layer does not include fibers knitted into a knitted fabric, but that the layer does not need to contain any fibers at all, such as formed films, sponges, foams, scrims, When a layer contains fibers, the fibers can be randomized (i.e., randomly arranged or consumed) (i. E., Mainly oriented in one direction and consumed). In addition, the layer may be a composite material comprising additional layers, i. E., A combination of layers, and random and spent fibers.

In one embodiment, the nonwoven layer of the substrate comprises a bet. Preferably, the nonwoven layer is of a lofty, non-abrasive, low density. Where "Lofty" used layer has a density of from about 0.00005 g / cm ³ to about 0.1 g / cm ^3, preferably from about 0.001 g / cm ³ to about 0.09 g / cm ^3, 5 in gms / in ² And has a thickness of about 0.04 inches to about 2 inches. The nonwoven layer comprising betting preferably comprises a synthetic material. &Quot; Synthetic " as used herein means that the material is primarily obtained from a variety of materials made by man or from further modified natural materials. Suitable synthetic materials include, but are not limited to, acetate fibers, acrylic fibers, cellulose ester fibers, modacryl fibers, polyamide fibers, polyester fibers, polyolefin fibers, polyvinyl alcohol fibers, rayon fibers, polyethylene foams, polyurethane foams, Water, but is not limited thereto. Preferred synthetic materials, particularly fibers, can be selected from the group consisting of nylon fibers, rayon fibers, polyolefin fibers, polyester fibers, and combinations thereof. Preferred polyolefin fibers are fibers selected from the group consisting of polyethylene, polypropylene, polybutylene, polypentene, and combinations and copolymers thereof. More preferred polyolefin fibers are fibers selected from the group consisting of polyethylene, polypropylene, and combinations and copolymers thereof. Preferred polyester fibers are fibers selected from the group consisting of polyethylene terephthalate, polybutylene terephthalate, polycyclohexylenedimethylene terephthalate, and combinations and copolymers thereof. More preferred polyester fibers are fibers selected from the group consisting of polyethylene terephthalate, polybutylene terephthalate, and combinations and copolymers thereof. The most preferred synthetic fibers contain short single-color polyester fibers containing a polyethylene terephthalate homopolymer. Suitable synthetic materials include, but are not limited to, monochromatic single component (i.e., chemically homogeneous) fibers, multicomponent fibers (i.e., one excess type of material making up each fiber), and multicomponent fibers Synthetic fibers containing two or more distinct filament types intertwined), and combinations thereof. Preferred fibers include bicomponent fibers, multicomponent fibers, and combinations thereof. The bicomponent fibers may be in a core-sheath arrangement or a side-by-side arrangement. In each case, the nonwoven layer may contain fibers comprising a combination of fibers containing the listed materials or a combination of the materials listed above as such.

A core-sheath fiber is that with respect to, preferably, the core comprises a material selected from the group consisting of polyester, polyolefin, and combinations thereof having at least about 10 ℃ higher T _g than the sheath material. Conversely, the sheath of the bicomponent fiber is preferably selected from polyolefins, polyesters having at least about 10 ℃ lower T _g than the core material is a polyolefin, and the group consisting of a combination thereof having at least about 10 ℃ lower T _g than the core material Lt; / RTI > More preferably, the core contains a polyester material and the sheath contains a polyethylene material.

In any case of a side-by-side arrangement, a core-sheath arrangement, or a monochrome single component arrangement, the fibers of the nonwoven layer can exhibit spiral or spiral or pleated arrangements, particularly bicomponent fibers.

The batting nonwoven layer may also include natural fibers.

In addition, the fibers of the batting nonwoven layer preferably have an average thickness of from about 0.5 microns to about 150 microns. More preferably, the average thickness of the fibers is from about 5 microns to about 75 microns. In an even more preferred embodiment, the average thickness of the fibers is from about 8 microns to about 40 microns. In addition, the fibers of the nonwoven layer can have various sizes. That is, the fibers of the nonwoven layer may contain fibers having various average thicknesses. The cross-section of the fibers may also be round, flat, oval, elliptical, or other shapes.

In another embodiment, the nonwoven layers of the present invention may be bonded together in a composite, i. E., Continuously (e. G., Laminated, etc.) or in a discontinuous pattern, or bonded together at the outer edge (or periphery) and / But may contain materials having one or more ply of the same or different suitable materials that are merely physically superimposed by bonding. For example, the nonwoven layer may also contain a composite selected from the group consisting of fibrous nonwoven, sponge, foam, reticulated foam, polymer net, scrim, vacuum-forming laminate, molded film and molded film composite . It is preferred that the layer of the vacuum-formed nonwoven fabric layer contains a molded film composite containing at least one nonwoven fabric and at least one molded film. Suitable molded film composites include, but are not limited to, a vacuum laminated composite formed film material formed from a combination of a forming film and a carded polypropylene nonwoven fabric having a basis weight of 30 gsm.

In another embodiment, the nonwoven layer is apertured. The voids in the nonwoven layer of the water-insoluble substrate will typically range in average diameter from about 0.5 mm to 5 mm. More preferably, the size of the pores will range from about 1 mm to 4 mm in size of the average diameter. Preferably, about 10% or less of the voids in the nonwoven fabric layer of the substrate will deviate from the size range. More preferably, about 5% or less of the voids of the nonwoven layer will be out of the size range. For pores that are not circular in shape, the "diameter" of pores refers to the diameter of a circular hole having the same surface area by opening a non-circular pore.

Within the nonwoven layer, the pores will typically be present at a frequency of about 0.5 to 12 pores per linear centimeter. More preferably, the voids in the surface of the layer will be present at a frequency of about 1.5 to 6 voids per linear centimeter.

The void should be located at least in the nonwoven layer. The voids do not have to protrude completely to the other side through one surface of the nonwoven layer. However, these can be. Additionally, the pores may or may not be located in the nonwoven layer of the substrate so that the article may be voided through its entire volume.

A void can be formed in the nonwoven layer of the water-insoluble substrate as the water-insoluble substrate or layer thereof is formed or fabricated. Alternatively, after the substrate comprising the layer is completely formed, a void may be formed in the nonwoven layer.

The nonwoven layer may contain a variety of natural and synthetic fibers or materials. &Quot; Natural " means that the substance is derived from plants, animals, insects or by-products of plants, animals, and insects. Conventional starting materials are usually fibrous webs containing any of the conventional synthetic or natural fabric-length fibers or combinations thereof.

Non-limiting examples of natural materials useful in the present invention include, but are not limited to, silk fibers, keratin fibers, and cellulosic fibers. Non-limiting examples of keratin fibers include those selected from the group consisting of wool fibers, camel hair fibers, and the like. Non-limiting examples of cellulosic fibers include wood pulp fibers, cotton fibers, hemp fibers, jute fibers, flax fibers, and mixtures thereof. Cellulose fiber materials are preferred in the present invention.

Non-limiting examples of synthetic materials useful in the present invention include but are not limited to acetate fibers, acrylic fibers, cellulose ester fibers, modacrylic fibers, polyamide fibers, polyester fibers, polyolefin fibers, polyvinyl alcohol fibers, rayon fibers, polyethylene foams, poly Urethane foam, and combinations thereof. Examples of suitable synthetic materials include acrylics such as acryllane, creslan, and acrylonitrile-based fibers, orrons; Cellulose ester fibers such as cellulose acetate, arnel and ascel; Polyamides such as nylon (for example, nylon 6, nylon 66, nylon 610 and the like); Polyesters such as Fortran, Cordel, polyethylene terephthalate fiber, polybutylene terephthalate fiber, Darkron; Polyolefins such as polypropylene and polyethylene; Polyvinyl acetate fibers; Polyurethane foams, and combinations thereof. These or other suitable fibers and nonwoven fabrics made therefrom are generally described in Riedel, " Nonwoven Bonding Methods and Materials " Nonwoven World (1987); The Encyclopedia Americana , Vol. 11, pp. Pp. 147-153, and vol. 26, pp. 566-581 (1984); USP 4,891,227, issued Feb. 1, 1990 to Thaman et al .; And USP 4,891,228, all of which are incorporated herein by reference.

Nonwoven fabrics made from natural materials most commonly consist of a web or sheet formed on a fine wire screen from a liquid suspension of fibers. See CA Hampel et al., The Encyclopedia of Chemistry , 3rd ed., 1973, pp. 793-795 (1973); The Encyclopedia Americana , vol. 376-383 (1984); And GA Smook, Handbook of Pulp and Paper Technologies , Technical Association for Pulp and Paper Industry (1986); All of which are incorporated herein by reference.

Natural material nonwovens useful in the present invention can be obtained from a wide variety of commercial sources. Non-limiting examples of suitable and commercially available suitable paper layers herein include: Airtex < RTI ID = 0.0 > , An emblaced and airlaid cellulosic layer having a basis weight of about 71 gsy, manufactured by James River, Green Bay, WI; And Walkisoft , Walkisoft USA, Mount Holly, NC, with an embossed, air-laid cellulosic layer having a basis weight of about 75 gsy. In manufacturing.

Additional suitable nonwoven materials include U.S. Pat. No. 4,447,294 (Osborn, issued May 8, 1984), each of which is incorporated herein by reference in its entirety; 4,603,176 (Bjorkquist, issued July 29, 1986); 4,981, 557 (Bjorkquist, granted 1 January 1991); 5,085, 736 (Bjorkquist, issued Feb. 4, 1992); 5,138,002 (Bjorkquist, issued Aug. 8, 1992); 5,262,007 (Phan et al., Granted November 16, 1993); 5,264,082 (Phan et al., Issued November 23, 1993); 4,637, 859 (Trokhan, issued January 20, 1987); 4,529,480 (Trokhan, issued July 16, 1985); 4,687,153 (McNeil, issued Aug. 18, 1987); 5,223, 096 (Phan et al., Issued June 29, 1993); And 5,679,222 (Rasch et al., Issued October 21, 1997), the disclosure of which is incorporated herein by reference.

Methods for making nonwoven fabrics are well known in the art. In general, these nonwoven fabrics can be made by air-laying, water-laid, meltblowing, coforming, spunbonding, or carding processes, wherein the fibers or filaments Is first cut from the long fibers to a desired length, passed through a water or air stream, and then passed through the screen with fiber-loaded air or water to deposit thereon. The resulting layer then undergoes one or more different types of bonding processes, regardless of its manufacturing method or composition, so that the individual fibers are anchored together to form a self-sustaining web. In the present invention, the nonwoven layer may be manufactured by a variety of processes, such as, but not limited to, air-entanglement, hydroentanglement, thermal bonding, and combinations of these processes.

Nonwovens made from synthetic materials useful in the present invention can be obtained from a wide variety of commercial sources. Non-limiting examples of suitable nonwoven layer materials useful herein include: HEF 40-047, voided with about 50% rayon and 50% polyester and having a basis weight of about 61 grams per square meter (gsm) , Apertured hydroentangled material, available from Veratec Inc., Walpole, MA; Wet entangled material containing HEF 140-102, about 50% rayon and 50% polyester and having a basis weight of about 67 gsm, available from Veratec Inc., Walpole, MA; Novonet 149-616, a thermo-bonded grid patterned material containing about 100% polypropylene and having a basis weight of about 60 gsm, available from Veratec Inc., Walpole, Mass .; Novonet 149-801, a thermally bonded lattice material containing about 69% rayon, about 25% polypropylene and about 6% cotton and having a basis weight of about 90 gsm, available from Veratec Inc., Walpole, MA; Novonet 149-191, about 69% rayon, about 25% polypropylene, about 6% cotton, and a basis weight of about 120 gsm, available from Veratec Inc., Walpole, MA; HEF Nubtex ^(R) 149-801, a nubbed, pore-formed, wet-knit material containing about 100% polyester and having a basis weight of about 84 gsm, available from Veratec Inc., Walpole, MA; Keybak 951 V, about 75% rayon, about 25% acrylic fiber, and having a basis weight of about 51 gsm, commercially available from Chicopee, New Brunswick, NJ; Keybak 1368, about 75% rayon, pore-formed material containing about 25% polyester and having a basis weight of about 47 gsm, available from Chicopee, New Brunswick, NJ; Duralace 1236, pore-forming, wet-knit material containing about 100% rayon and having a basis weight of from about 48 gsm to about 138 gsm, available from Chicopee, New Brunswick, NJ; Duralace 5904, pore-forming, wet-knit material containing about 100% polyester and having a basis weight of about 48 gsm to about 138 gsm, available from Chicopee, New Brunswick, NJ; Chicopee 5763, about 70% rayon, about 30% polyester, and optionally about 5% w / w or less latex binder (based on acrylate or EVA) and having a mood weight of about 60 gsm to about 90 gsm Wet entangled material (8 x 6 voids per inch, 3 x 2 voids per cm), available from Chicopee, New Brunswick, NJ; Chicopee 50% polyester to 0% rayon / 100%), 100% rayon / 9900 series (e.g. Chicopee 9931, 62 gsm, 50/50 rayon / polyester and Chicopee 9950 50 gsm, 50/50 rayon / polyester) Wet, entangled material containing a fiber composition of 100% polyester or 100% rayon / 0% polyester and having a basis weight of about 36 gsm to about 84 gsm, available from Chicopee, New Brunswick, NJ; Sontara 8868, a wet tangled material containing about 50% cellulose and about 50% polyester and having a basis weight of about 72 gsm, available from Dupont Chemical Corp. Preferred nonwoven substrate materials have a basis weight of from about 24 gsm to about 96 gsm, more preferably from about 36 gsm to about 84 gsm, and most preferably from about 42 gsm to about 78 gsm.

The nonwoven layer may also be a polymeric mesh sponge as described in European Patent No. 702550 Al, published March 27, 1996, the entirety of which is incorporated herein by reference. The polymeric mesh sponge comprises several layers of extruded tubular netmeshes made of polymers or nylons with strong stretch properties, such as the addition polymers of olefin monomers and polyamides of polycarboxylic acids.

The nonwoven layer may also include multiple materials including molded films and composites, such as molded films. Preferably, the forming film comprises plastic that tends to soften the skin. Suitable soft plastic forming films include, but are not limited to, polyolefins such as low density polyethylene (LDPE). In the case where the nonwoven layer comprises a plastic forming film, it is preferred that the nonwoven layer is voided, for example macroapertured or microapertured, so that the layer is fluid permeable. In one embodiment, the nonwoven layer contains a plastic forming film having only micropores. The surface strain, i.e. the male side, of the one with microvoids is preferably located on the inner surface of the second layer, preferably towards the interior of the substrate, i.e. the therapeutic efficacy component. In certain embodiments that include voids with petal-like edge surface deformations, regardless of theory, the application of pressure to the article by hand, when the surface deformation of the voids faces the therapeutic efficacy member, It is believed that by folding the mold edge into the interior it is possible to create numerous valves on the inner surface of the layer that actually meter out the absence of therapeutic efficacy contained within the article to extend the useful life of the article.

In another embodiment, the nonwoven layer contains a plastic forming film having both micropores and large voids. In this embodiment, the nonwoven layer is well suited for contacting the micropores at the site to be treated therapeutically while providing a cloth-like feel of the formed film. Preferably, in this embodiment, the surface deformation of the micropores is directed against the surface deformation of the large voids on the nonwoven layer. In this case, the large voids are judged to form rich foam by maximizing the overall wetting / foaming of the article by the three-dimensional thickness formed from surface deformation under constant compression and decompression during use of the article.

In any case, the nonwoven layer containing the forming film has a porosity of at least about 100 voids / cm ² , more preferably at least 500 voids / cm ² , even more preferably at least about 1000 voids / cm ² , it has a void / ㎝ ² of the substrate at least about 1500. A more preferred embodiment of the present invention is a solution of about 5 cm ³ / cm ² -s to about 70 cm ³ / cm ² -s, more preferably about 10 cm ³ / cm ² -s to about 50 cm ³ / cm ² - s, and most preferably from about 15 cm ³ / cm ² -s to about 40 cm ³ / cm ² -s.

Suitable molded films and molded film-containing composites useful in the nonwoven layer of the present invention include those disclosed in U.S. Patent No. 4,342,314 (Radel et al., Issued August 3, 1982), each of which is incorporated herein by reference in its entirety (U.S. Serial No. 08 / 326,571 and PCT Application No. 95/07435, filed June 12, 1995, published January 11, 1996), and U.S. Patent Application No. 4,629,643 (Curro et al. , Issued December 16, 1986, which is incorporated herein by reference). In addition, the nonwoven layer can be a molded film composite that includes at least one formed film and at least one nonwoven fabric in which the layer is formed in vacuum. Suitable molded film composites include, but are not limited to, vacuum laminated composite formed film materials formed by combining a molded film and a carded polypropylene nonwoven having a basis weight of 30 gsm.

Additionally, the nonwoven layer and any additional layers are preferably bonded together to maintain the integrity of the article. The bonding may be effected by bonding at the outer edge (or periphery) of the layer and / or at a specific location or combination thereof, or by spot bonding (e.g., hot point bonding), continuous bonding , Laminated, etc.). When spot bonding is used in the present article, the spot bonding is preferably separated by a distance of about 1 cm or more. However, in certain instances, bonding may be arranged to be formed on the outer surface of the article and layer in which geometric shapes and patterns, such as diamonds, circles, squares, etc., are produced.

It is also contemplated that in the article of the present invention the nonwoven layer and any additional layers may be surface modified to form a single composite layer having two sides with different textures. Thus, in practice, the water-insoluble substrate may be understood to comprise a single composite layer with a bi-textured side or surface.

In any case, the bonding area present between the nonwoven layer and any additional layers is at most about 50%, preferably at most about 15%, more preferably at most about 10% of the total surface area of the layer, About 8% or less.

Each layer discussed herein may include two or more surfaces, i. E. An inner surface and an outer surface, each having the same or different texture and abrasive. Preferably, the article of the invention contains a substrate and thus a soft layer on the skin. However, different textured substrates may be due to the use of different combinations of materials or the use of different manufacturing processes or combinations thereof. For example, water-insoluble substrates of bi-textures may be prepared to provide a more abrasive side for exfoliation and an advantageous personal care article with a milder cleansing and / or softer, absorbent aspect for therapeutic treatment . In addition, the individual layers of the substrate can be fabricated to have different tints to help the user further distinguish the surface.

In addition, each of the layers of the article and the article itself can be made in a wide variety of shapes and forms, such as flat pads, thick pads, thin sheets, spherical tools, and irregular tools. The exact size of the layer will depend on the intended use and the properties of the article, and the surface area may vary from about 1 in ² to about several hundred in ² . Particularly convenient layer and article forms have a surface area of from about 5 in ² to about 200 in ² , preferably from about 6 in ² to about 120 in ² , more preferably from about 15 in ² to about 100 in ² , circular, rectangular, hourglass, mitt or egg with a thickness of from about 1 mm to about 50 mm, more preferably from about 1 mm to about 25 mm, and more preferably from about 2 mm to about 20 mm, But is not limited thereto.

Wear Value Methodology

The wear values represent the " non-abrasive " nature of the nonwoven layer of the article of the present invention. The nonwoven fabric layer of the present invention moderately exfoliates, but is not rough on the skin. The wear value determination thus involves scratching the test surface of the substrate using a mechanical device and then examining the scratch marks of the results produced on the test surface using different analytical techniques.

The following apparatus is required for the methodology.

1. Martindale Toothbrush Abrasion Tester: Model 103, Serial No. 103-1386 / 2 or higher. Martindale 07-01-88, James H. Heal and Co. Ltd. Produce. Fabric testing and QC equipment. Machine foot area: 43x44 mm. 1 kg weight.

2. Capped polystyrene slices 11x8 cm. A clean general purpose polystyrene layer on white high impact polystyrene, for example EMA Model Supply No. SS-20201L.

3. The substrate to be tested.

4. Gloss system, for example Sheen Tri-Microgloss 20-60-85.

Remove the plastic protective coating from the side to be scratched and rinse with ethanol (not using tissue paper) to prepare a piece of polystyrene for scratching. The slices are placed on a non-smearable surface and the slices are dried in air. Then, using tape, along the edge, attach a piece of polystyrene to the bottom of the Martindale abrasion tester. At the center of the path of the scrubbing device, arrange the pieces by placing the pieces in the direction of motion. Cut the 2.5 "x 2.5" substrate. The base samples were attached to the scrubbing foot of the Martindale abrasion tester by arranging the machine direction of the substrate in the reciprocating direction using a double-sided tape. Secure the scrubbing foot assembly into the instrument with the provided screws. 1 kg weight is applied to the top of the scrubbing foot assembly to ensure that the scrubbing foot moves in only one direction (back and forth). Cover the entire Martindale abrasion testing machine with a safety screen. Set up and start the machine to run 50 cycles per minute (frequency = 0.833 Hz). Once the machine stops, remove the foot assembly and lift the polystyrene pieces from the bottom of the machine. Add a label to the polystyrene indicating that the label is used and store it in a plastic bag.

Then, analyze the pieces. Based on black construction paper, lay the pieces on top of it and analyze five or more identical substrate samples to obtain reproducible averages. With respect to the scratch surface of the polystyrene pieces, place a right angle (so that the ray is perpendicular to the scratch) and a gloss meter in the center. Select a 20 ° angle and measure the sample to determine the wear value. If the wear value is reduced, the scratch or stripping properties of the substrate are increased.

Absence of therapeutic efficacy

The article of the invention further comprises a safe effective amount of a therapeutic benefit member. The efficacious member is disposed adjacent to the water insoluble substrate and comprises from about 10% to about 1000%, more preferably from about 10% to about 500%, most preferably from about 10% to about 10% 250% by weight of a hydrophilic conditioning agent, wherein when the article is exposed to water, the hydrophilic conditioning agent has a leaching value of less than about 25% per minute and less than about 50% per 5 minutes . Preferably, the hydrophilic conditioning agent is less than about 15% at 1 minute, less than about 30% at 5 minutes, more preferably less than about 10% at 1 minute, less than about 20% at 5 minutes, more preferably less than about 1% Min, less than about 5% at 5 minutes, less than about 10% at 5 minutes, most preferably less than about 2.5% at 1 minute and less than about 8% at 5 minutes.

The leach value of the hydrophilic conditioning agent (e.g., glycerin) is measured using the following materials:

1. Gas chromatograph (for example, HP5890 with capillary injection system, flame ionization detector and data processing system)

2. 150 ml beaker with stirring bar

3. 100 ml graduated cylinder

4. Pipette with 5 ml pipette

5. Tap water at 98 ° F to 104 ° F

6. Add 20 ml vials for 5 ml aliquots

7. Timer

8. A water bath (for example, a deep dish on a heating plate)

9. A personal care article containing a hydrophilic conditioning agent (e.g., glycerin) cut to 6 x 6 cm

10. 10-100 [mu] l variable volume pipetter

11. 100-1000 [mu] l variable volume pipettor

12. Pyrex 13x100 mm glass culture tube with Teflon line-treated spinneret

13. Analytical Balance

14. Centrifuge (for example, Savant Speed Vac)

15. Glass GC vial with Teflon line treated stopper

Standard substrates and specific materials

Proposed source or formulation (Or equivalent) Methanol ACS reagent grade, J.T. Bakercat. no. 9070-33 Sylon BFT (bis (trimethylsilyl) trifluoroacetamide: trimethylchlorosilane 99: 1) Supelco Cat. # 3-3149 Tridecanol 98% minimum purity, ICNBiomedicals Cat. # 156998 Hydrophilic conditioning agent (glycerin) USP, J.T. Baker Cat. # 2140-01

Standard water

Internal Standard Solution (ISTD) Weigh 500 mg ± 20 mg tridecanol in a 10 mL volumetric flask, weigh accurately to 0.1 mg and record the weight. Dilute to volume with methanol, close the stopper and mix well. Calibration standard Add 50 mg ± 5 mg of glycerin to a 10 mL volumetric flask, weigh accurately to 0.1 mg and record the weight. Dilute to volume with methanol, close the stopper and mix well Additional standards are prepared in a 10 mL volumetric flask, with continuous dilution, at the following concentrations: 2500, 1000, and 500 ug / mL

A standard is prepared as described above. For each standard, attach a label to a Pyrex 13x100 mm rotary cap culture tube. Pipette 100 μl of each glycerin standard (5000, 2500, 1000 and 500 μg / mL) into the corresponding tubes. Pipette 50 μL of 5 mg / mL tridecanol in internal standard water methanol into each tube. Using a Speed Vac, centrifuge the standard under vacuum until dry. Add 500 [mu] l of Sylon BFT, stopper and heat at 85 [deg.] C for 30 minutes. Transfer to a GC vial and inject into GC.

Allow the water bath to 98 ° F to 104 ° F. 100 ml of tap water is measured in a beaker using a graduated cylinder. Place the stir bar and place the beaker in a few baskets. 4 Set the agitation in the setting. The product is placed in stirred water and a timer is activated. After 1 minute, 5 ml of water is removed using a pipette, and the sample is placed in a 20 ml vial. After an additional 4 minutes (5 minutes from the start of timing), 5 ml is removed using a pipette and the sample is placed in a 20 ml vial.

Transfer the sample to a 13x100 mm glass culture tube with a labeled, Teflon line-lined rotating cap. Each scintillation vial is rinsed with 1 ml of methanol. The methanol rinse solution is added to a suitable 13x100 mm culture tube. 50 μl of internal standard, 5 mg / ml tridecanol in methanol is pipetted into each tube. Using a Speed Vac, the samples are centrifuged to dry under vacuum. 500 μl of Sylon BFT is added, the stopper is capped and heated at 85 ° C for 30 minutes. Transfer to a GC vial and inject into GC.

Prepare the gas chromatograph as follows.

Chromatographic conditions Carrier gas Purified helium and oxygen scrubber through a gas purifier. Conveying pressure 15 psi, constant pressure mode Split flow 20: 1 Inlet temperature 310 ° C Injection volume 1 μl Oven temperature program Speed: 80 ° C → 325 ° C @ 15 ° C / minute Temperature: 5 minutes 325 ° C Detector temperature 350 ℃ Detector flow: air column + make-up hydrogen 380-420 mL / min 29-31 mL / min 29-31 mL / min

Once the instrument is set up to operate under the conditions indicated in the above table, the integrator or data processing system is set up to calculate the weight of the hydrophilic conditioning agent (e.g., glycerin) in the sample according to the following equations:

Reaction factor (calculated for each component) = {(A) (B)} / {(C) (D)}

[Wherein:

A = area of internal standard in calibration solution

B = weight of hydrophilic conditioning agent (glycerin) in calibration solution (grams)

C = weight of internal standard in calibration solution (grams)

D = area of the hydrophilic conditioning agent (glycerin) in the calibration solution]

Amount of hydrophilic conditioning agent in sample ()) = (RF) (E) (F) / (G)

[Wherein:

RF = reaction factor calculated in the above equation

E = weight of internal standard in sample solution (g)

F = area of hydrophilic conditioning agent (glycerin) in sample solution

G = area of internal standard in sample solution]

Thereafter, the leaching value (%) is obtained by dividing the amount of the hydrophilic conditioning agent in the sample by the total amount of the hydrophilic conditioning agent in the article before immersion.

Preferably, the therapeutic efficacy composition of the present invention further comprises a therapeutic efficacy agent selected from the group consisting of a hydrophobic conditioning agent, a structured conditioning agent, and combinations thereof.

Hydrophilic conditioning agent

The article of the present invention contains one or more hydrophilic conditioning agents. Non-limiting examples of hydrophilic conditioning agents include polyhydric alcohols, polypropylene glycols, polyethylene glycols, urea, pyrrolidonecarboxylic acids, ethoxylated and / or propoxylated C3 to C6 diols and triols, alpha-hydroxy C2- C6 carboxylic acid, ethoxylated and / or propoxylated sugar, polyacrylic acid copolymer, sugar having less than about 12 carbon atoms, sugar alcohol having less than about 12 carbon atoms, and mixtures thereof. Specific examples of useful hydrophilic conditioning agents include urea; Guanidine; Glycolic acid and glycolate salts such as ammonium and quaternary alkylammonium; Lactic acid and lactate salts (e.g., ammonium and quaternary alkylammonium); Sucrose, fructose, glucose, errourous, erythritol, sorbitol, mannitol, glycerol, hexanetriol, propylene glycol, butylene glycol, hexylene glycol and the like; 15, PPG-17, PPG-20, PPG-26, PPG-30, PPG-9, PPG-12, PEG- Polypropylene glycols such as 34; Alkoxylated glucose; Hyaluronic acid; Cationic skin conditioning polymers (e.g., quaternary ammonium polymers such as polyquaternium polymers); And mixtures thereof. In particular, glycerol is the preferred hydrophilic conditioning agent in the articles of the present invention. In addition, various optional forms of aloe vera (e.g., aloe vera gel), chitosan and chitosan derivatives such as chitosan lactate, lactam monoethanolamine; Acetamide monoethanolamine; And mixtures thereof are also useful. Also useful are propoxylated glycerol as described in the propoxylated glycerol described in U.S. Patent No. 4,976,953 (Orr et al., Issued December 11, 1990), which is hereby incorporated by reference in its entirety.

Hydrophobic conditioning agent

The article of the present invention may contain one or more hydrophobic conditioning agents useful for imparting a conditioning effect to the skin or hair during use of the article. The article of the present invention is preferably present in an amount of from about 0.5% to about 1,000% by weight, more preferably from about 1% to about 200% by weight, and most preferably from about 10% to about 100% by weight, % Of a hydrophobic conditioning agent.

The hydrophobic conditioning agent may be selected from one or more hydrophobic conditioning agents such that the weighted arithmetic mean solubility parameter of the hydrophobic conditioning agent is less than or equal to 10.5. Based on the mathematical definition of the solubility parameter, for example, for a hydrophobic conditioning agent containing two or more compounds, even if the individual solubility parameter of one of the compounds is greater than 10.5, the desired weighted arithmetic mean solubility parameter, i.e., 10.5 It is possible to achieve the following.

Solubility parameters are well known to those of skill in the art of formulations and are routinely used as a guide to determine the compatibility and solubility of materials within a formulation process.

The solubility parameter, delta, of a chemical compound is defined as the square root of the cohesive energy density of the compound. Typically, the solubility parameter of a compound is calculated from the tabulated values of the molar volume and the adduct contribution to the heat of vaporization of the components of the compound using the following equation:

(Where Σ _i E _i = sum of contributions of vapor-phase heat additions and Σ _i m _i = sum of molar volume anomalies).

The creation of a standard table of heat of vaporization and molar volume contribution to a wide variety of atoms and groups is described in Barton, AFM Handbook of Solubility Parameters , CRC Press, Chapter 6, Table 3, pp . 64-66 (1985). The solubility parameter formulas are described in detail in Fedors, RF, " A Method for Estimating Both Solubility Parameters and Molar Volumes of Liquids ", Polymer Engineering and Science , vol. 14, no. 2, pp. 147 to 154 (February 1974).

The solubility parameter follows a mixture law that the solubility parameter for a mixture of materials is given by the weighted arithmetic mean (i.e., weighted average) of the solubility parameter for each component of the mixture. Quot ; Handbook of Chemistry and Physics , < RTI ID = 0.0 > 57th Edition, CRC Press, p. C-726 (1976-1977).

Formulation chemists typically report solubility parameters in units of (cal / cm 3) ^1/2 and report. In the [ Handbook of Solubility Parameters] tabulated values for the contribution of vaporization heat are reported in kJ / mol. However, these tabulated vaporization heat values are readily converted to cal / mol using the well-known correlation: < RTI ID = 0.0 >

1 J / mol = 0.239006 cal / mol and 1000 J = 1 kJ

(Gordon, AJ et al., The Chemist's Companion , John Wiley & Sons, pp. 456 ~ 463 (1972).

In addition, the solubility parameters for a wide variety of chemicals are tabulated. Preparation of a table of solubility parameters is shown in the cited Handbook of Solubility Parameters . See also " Solubility Effects In Product, Package, Penetration, And Preservation ", CD Vaughan, Cosmetics and Toiletries , vol. 103, October 1988, pp. 47 ~ 69].

Non-limiting examples of hydrophobic conditioning agents include mineral oil, petrolatum, lecithin, hydrogenated lecithin, lanolin, lanolin derivatives, C7 to C40 branched chain hydrocarbons, C1 to C30 alcohol esters of C1 to C30 carboxylic acids, C2 A C1 to C30 alcohol ester of a C30 dicarboxylic acid, a monoglyceride of a C1 to C30 carboxylic acid, a diglyceride of a C1 to C30 carboxylic acid, a triglyceride of a C1 to C30 carboxylic acid, Ethylene glycol diesters of C1 to C30 carboxylic acids, propylene glycol monoesters of C1 to C30 carboxylic acids, propylene glycol diesters of C1 to C30 carboxylic acids, C1 to C30 carboxylic acid monoesters of sugars, Polydialkylsiloxane, polyalkarylsiloxane, cyclomethicone having 3 to 9 silicon atoms, vegetable oil, hydrogenated vegetable oil, polypropylene glycol C4- C20 alkyl ethers, di C8-C30 alkyl ethers, and combinations thereof.

Mineral oil, also known as Petrolatum liquid, is a mixture of liquid hydrocarbons obtained from petroleum. The Merck Index, 10th ed., 7048, p. 1033 (1983) and International Cosmetic Ingredient Dictionary, 5th edition, vol. 1, p. 415-417 (1993).

Petroleum jellies, also known as petroleum jelly, are colloidal systems of non-linear solid hydrocarbons and high boiling liquid hydrocarbons, and most of the liquid hydrocarbons are contained within the micelles. Which are incorporated herein by reference in their entirety, The Merck Index, 10th ed., 7047, p. 1033 (1983); [Schindler, Drug. Cosmet. Ind. , 89 , 36-37, 76, 78-80, 82 (1961)]; And International Cosmetic Ingredient Dictionary, 5th Edition, vol. 1, p. 537 (1993).

Lecithin is also useful as a hydrophobic conditioning agent. It is a naturally occurring mixture of diglycerides of certain fatty acids linked to a choline ester of phosphoric acid.

Straight chain and branched chain hydrocarbons having about 7 to about 40 carbon atoms are useful herein. Non-limiting examples of these hydrocarbon materials include dodecane, isododecane, squalane, cholesterol, hydrogenated polyisobutylene, docosane acid (i.e., C ₂₂ hydrocarbon), hexadecane, iso-hexadecane (Presperse (South Plainfield, NJ Material ) In Permethyl ≪ RTI ID = 0.0 > 101A < / RTI > C7-C40 isoparaffins, C7-C40 branched hydrocarbons, are also useful. Polydecene, a branched liquid hydrocarbon, is also useful here, which is available from Mobile Chemical (Edison, NJ) under the trade name Puresyn 100 And Puresyn 3000 .

Also useful are C1 to C30 carboxylic acids and C1 to C30 alcohol esters of C2 to C30 dicarboxylic acids, including straight and branched chain materials as well as aromatic derivatives. It is also possible to use monoglycerides of C1 to C30 carboxylic acids, diglycerides of C1 to C30 carboxylic acids, triglycerides of C1 to C30 carboxylic acids, ethylene glycol monoesters of C1 to C30 carboxylic acids, Esters such as ethylene glycol diesters, propylene glycol monoesters of C1 to C30 carboxylic acids, and propylene glycol diesters of C1 to C30 carboxylic acids are also useful. Straight chain, branched chain and aryl carboxylic acids are also included herein. Propoxylated and ethoxylated derivatives of these materials are also useful. Non-limiting examples include diisopropyl sebacate, diisopropyl adipate, isopropyl myristate, isopropyl palmitate, myristyl propionate, ethylene glycol distearate, 2-ethylhexyl palmitate, isodecyl neopenta Maleic anhydride, di-2-ethylhexyl maleate, cetyl palmitate, myristyl myristate, stearyl stearate, cetyl stearate, behenyl behenate, dioctyl maleate, dioctyl sebacate, diisopropyl adipate , Cetyl octanoate, diisopropyldrinoleate, caprylic / capric acid triglyceride, PEG-6 caprylic / capric acid triglyceride, PEG-8 caprylic / capric acid triglyceride, and combinations thereof Water is included.

Various C1 to C30 monoesters and polyesters of sugars and related substances are also useful. The ester is derived from a sugar or polyol moiety and at least one carboxylic acid moiety. Depending on its constituent acid and sugar, the ester may be in the form of a liquid or solid at room temperature. Examples of liquid esters include: glucose tetraoleate, glucose tetraester of soybean oil fatty acid (unsaturated), mannose tetraester of mixed soybean fatty acid, galactose tetraester of oleic acid, arabinose tetraester of linoleic acid, xylose Sorbitol tetraoleate, sorbitol hexaester of unsaturated soybean oil fatty acid, xylitol pentaoleate, sucrose tetraoleate, sucrose pentaoleate, sucrose hexaoleate, sucrose heptaoleate, sucrose tetraoleate, , Sucrose octaoleate, and mixtures thereof. Examples of solid esters include: sorbitol hexaester in which the carboxylic acid ester moiety is palmitoleate and arachidate in a 1: 2 molar ratio; Octaesters of raffinose wherein the carboxylic acid ester moiety is linoleate and behenate in a 1: 3 molar ratio; A hepta ester of maltose wherein the esterified carboxylic acid moiety is sunflower seed oil fatty acid and lignocerate of 3: 4 molar ratio; Octaesters of sucrose in which the esterified carboxylic acid moiety is an oleate of 2: 6 molar ratio and behenate; And an octaester of sucrose wherein the esterified carboxylic acid moiety is laurate, linoleate and behenate in a 1: 3: 4 molar ratio. Preferred solid materials are sucrose polyesters, which are C18 mono- and / or di-unsaturated and behenic, with a degree of esterification of from 7 to 8 and a fatty acid moiety of from 1: 7 to 3: 5 in the unsaturated: behenic moiety. Particularly preferred solid sugar polyesters are sucrose octaesters having about 7 beef fatty acid moieties and about 1 oleic acid moiety in the molecule. Other materials include cottonseed oil or soybean oil fatty acid esters of sucrose. The ester materials are described in U.S. Patent No. 2,831,854, U.S. Patent No. 4,005,196 [Jandacek, issued January 25, 1977], each of which is incorporated herein by reference in its entirety; U.S. Patent No. 4,005,195 [Jandacek, issued January 25, 1977], U.S. Patent No. 5,306,516 [Letton et al., Issued April 26, 1994]; U.S. Patent No. 5,306,515 [Letton et al., Issued April 26, 1994]; U.S. Patent No. 5,305,514 [Letton et al., Issued April 26, 1994]; U.S. Patent No. 4,797,300 [Jandacek et al., Issued January 10, 1989]; U.S. Patent No. 3,963,699 [Rizzi et al., Issued June 15, 1976]; U.S. Patent No. 4,518,772 [Volpenhein, issued May 21, 1985]; And U.S. Patent No. 4,517,360 [Volpenhein, issued May 21, 1985].

Non-volatile silicones such as polydialkylsiloxanes, polydialylsiloxanes, and polyalkarylsiloxanes are also useful oils. These silicones are described in U.S. Pat. No. 5,069,897 [Orr, 3 December 1991], which is hereby incorporated by reference in its entirety. The polyalkyl siloxane corresponds to the general formula R ₃ SiO [R ₂ SiO] _x SiR _{3 wherein} R is an alkyl group (preferably R is methyl or ethyl, more preferably methyl) Which is an integer less than or equal to about 500 selected to achieve. Commercially available polyalkylsiloxanes include polydimethylsiloxanes, also known as dimethicone; Non-limiting examples thereof include Vicasil Series (General Electric Company sales), and Dow Corning 200 series (sold by Dow Corning Corporation). Specific examples of useful polydimethylsiloxanes herein include Dow Corning, having a viscosity of 10 centistoke and a boiling point of greater than 200 < RTI ID = 0.0 > 225 fluid, and a viscosity of 50,350, and 12,500 centistokes, respectively, and a boiling point greater than 200 < 0 & 200 fluid. Also provided is a polymeric material corresponding to the general formula [(CH ₂ ) ₃ SiO _1/2 ] _x [SiO ₂ ] _{y wherein} x is an integer from about 1 to about 500, y is from about 1 to about 500 Lt; / RTI > is an integer). Also useful are materials such as trimethylsiloxysilicate. Commercially available trimethylsiloxysilicates are commercially available from Dow Corning, a mixture with dimethicone, 593 fluid. Dimethicol, a hydroxy-terminated dimethyl silicone, is also useful herein. These materials can be represented by the general formulas R ₃ SiO [R ₂ SiO] _x SiR ₂ OH and HOR ₂ SiO [R ₂ SiO] _x SiR ₂ OH (wherein R is an alkyl group Ethyl, more preferably methyl), and x is an integer of about 500 or less selected to achieve the desired molecular weight. Commercially available dimethiconols are typically sold as a mixture with dimethicone or cyclomethicone (see, e.g., Dow Corning 1401, 1402, and 1403 fluids). Polyalkylarylsiloxanes are also useful herein and are preferably polymethylphenylsiloxanes having a viscosity of about 15 to about 65 centistokes at 25 캜. These materials are available, for example, as SF 1075 methylphenyl fluids (sold by General Electric Company) and 556 cosmetic grade phenyl trimethicone fluids (sold by Dow Corning Corporation). Alkylated silicones such as methyldecylsilicon and methyloctylsilicon are also useful herein and are commercially available from General Electric Company. Also useful are alkyl modified siloxanes such as alkyl methicone and alkyl dimethicone wherein the alkyl chain contains from 10 to 50 carbons. These siloxanes are commercially available under the trade names ABIL WAX 9810 (C ₂₄ -C ₂₈ alkylmethicone) (sold by Goldschmidt) and SF 1632 (cetearyl methicone) sold by General Electric Company.

Vegetable oils and hydrogenated vegetable oils are also useful herein. Examples of vegetable oils and hydrogenated vegetable oils include safflower oil, castor oil, coconut oil, cottonseed oil, menhaden oil, palm kernel oil, palm oil, peanut oil, soybean oil, rapeseed oil, flaxseed oil, , Hydrogenated coconut oil, hydrogenated cottonseed oil, hydrogenated chenille oil, hydrogenated coconut oil, hydrogenated palm oil, hydrogenated peanut oil, hydrogenated soybean oil, hydrogenated rapeseed oil, hydrogenated coconut oil, hydrogenated coconut oil, hydrogenated coconut oil, hydrogenated coconut oil, hydrogenated coconut oil, Hydrogenated flaxseed oil, hydrogenated unsweetened oil, hydrogenated sesame oil, hydrogenated sunflower seed oil, and mixtures thereof.

C4-C20 alkyl ethers of polypropylene glycol, C1-C20 carboxylic acid esters of polypropylene glycol, and di-C8-C30 alkyl ethers are also useful herein. Non-limiting examples of these materials include PPG-14 butyl ether, PPG-15 stearyl ether, dioctyl ether, dodecyl octyl ether, and mixtures thereof.

Hydrophobic chelating agents are also useful herein as hydrophobic conditioning agents. Suitable materials are described in U.S. Patent No. 4,387,244 [Scanlon et al., Issued June 7, 1983], and co-pending U.S. Patent Application Serial Nos. 09 / 258,747 and 09 / 259,485 [issued Feb. 26, 1999 to Schwartz et al Quot; filed on < / RTI >

The absence of therapeutic efficacy can be produced in various forms. In one embodiment of the invention, the absence of therapeutic efficacy is in the form of an emulsion. For example, water-in-oil, water-in-oil, water in water, and water-in-oil emulsions in silicone are useful herein. As used in connection with emulsions, " water " may refer to water-miscible materials such as water-soluble or glycerin as well as water.

Preferred therapeutic efficacy elements include emulsions that additionally comprise an aqueous phase and an oil phase. As will be appreciated by those skilled in the art, a given member will be predominantly distributed within the water or oil phase depending on the solubility / dispersibility of the therapeutic agent in the member. In one embodiment, the oil phase contains at least one hydrophobic conditioning agent. In another embodiment, the water phase contains one or more hydrophilic conditioning agents.

The therapeutic efficacy components of the invention, which are in emulsion form, generally contain an aqueous and oily or lipid phase. Suitable oils or lipids may be derived from animals, plants or petroleum, and may be natural or synthetic (i.e., synthetic). Such oils are those discussed above in the section on hydrophobic conditioning agents. Suitable aqueous phase ingredients include the hydrophilic conditioning agents discussed above. Preferred emulsion forms include water-in-oil emulsions, water-in-silicone emulsions, and other reversed-phase emulsions. Additionally, preferred emulsions also contain a hydrophilic conditioning agent, such as glycerin, to allow glycerine-type emulsions in the oil to be produced.

The absence of therapeutic efficacy in the form of an emulsion will preferably additionally contain from about 1% to about 10%, more preferably from about 2% to about 5%, by weight of the emulsifying agent, relative to the absence of therapeutic efficacy . The emulsifying agent may be nonionic, anionic or cationic. Suitable emulsions are described, for example, in U.S. Patent No. 3,755,560 [Dickert et al., Issued Aug. 28, 1973]; U.S. Patent No. 4,421,769 [Dixon et al., Issued December 20, 1983]; And McCutcheon ' s Detergents and Emulsifiers , North American Edition, p. 317-324 (1986). In addition, the absence of therapeutic efficacy in the form of emulsions may also include defoamers to minimize foaming upon application to the skin. Defoamers include high molecular weight silicones and other materials well known in the art for this purpose.

The absence of therapeutic efficacy may also be in the form of a microemulsion. As used herein, " microemulsion " refers to a thermodynamically stable mixture of two immiscible solvents (one non-polar and one polar) stabilized by a surfactant that is an amphiphilic molecule. Preferred microemulsions include water-in-oil microemulsions.

Structured Conditioning Agents

The absence of therapeutic efficacy may include structured conditioning agents. Suitable structured conditioning agents include, but are not limited to, vesicular structures such as ceramides, liposomes, and the like.

In another embodiment, a therapeutic benefit agent in the absence of therapeutic efficacy is contained in a coacervate-forming composition. Preferably, the coacervate-forming composition contains a cationic polymer, an anionic surfactant, and a dermatologically acceptable carrier of a polymer and a surfactant. The cationic polymer may be selected from the group consisting of natural backbone quaternary ammonium polymers, synthetic backbone quaternary ammonium polymers, natural backbone polymers, synthetic backbone polymers, and combinations thereof.

More preferably, the cationic polymer is selected from the group consisting of polyquaternium-4, polyquaternium-10, polyquaternium-24, PG-hydroxyethyl cellulose alkyldiammonium chloride, guar hydroxypropyl trimonium chloride, A natural backbone quaternary ammonium polymer selected from the group consisting of hydroxypropyltrimethoxypropyltrimonium chloride, hydroxypropylglyhydroxypropyltrimonium chloride, and combinations thereof; Polyquaternium-6, polyquaternium-7, polyquaternium-11 polyquaternium-16, polyquaternium-17, polyquaternium-18, polyquaternium-28, polyquaternium- -32, polyquaternium-37, polyquaternium-43, polyquaternium-44, polyquaternium-46, polymethacylamidopropyltrimonium chloride, acrylamidopropyltrimonium chloride / acrylamide copolymer, A synthetic backbone quaternary ammonium polymer selected from the group consisting of: Natural backbone ampholytic polymers selected from the group consisting of chitosan, quaternized proteins, hydrolyzed proteins and combinations thereof; Polyquaternium-22, polyquaternium-39, polyquaternium-47, adipic acid / dimethylaminohydroxypropyl diethylenetriamine copolymer, polyvinylpyrrolidone / dimethylaminoethyl methacrylate copolymer, vinyl Caprolactam / polyvinylpyrrolidone / dimethylaminoethyl methacrylate copolymer, vinylcaprolactam / polyvinylpyrrolidone / dimethylaminopropyl methacrylamide terpolymer, polyvinylpyrrolidone / dimethylaminopropyl methacrylamide copolymer Is selected from the group consisting of synthetic backbone ampholytic polymers selected from the group consisting of polyamines, polyamines, polyamines, and combinations thereof. Even more preferably, the cationic polymer is a synthetic backbone amphoteric polymer. Even more preferably, the cationic polymer is a polyamine.

When the cationic polymer is a polyamine, the cationic polyamine polymer is preferably selected from the group consisting of polyethyleneimine, polyvinylamine, polypropyleneimine, polylysine, and combinations thereof. More preferably, the cationic polyamine polymer is a polyethyleneimine.

In certain embodiments in which the cationic polymer is a polyamine, the polyamine can be modified hydrophobically or hydrophilically. In the above examples, the cationic polyamine polymer is selected from the group consisting of benzylated polyamines, ethoxylated polyamines, propoxylated polyamines, alkylated polyamines, amidated polyamines, esterified polyamines, and combinations thereof. The coacervate forming composition comprises from about 0.01% to about 20%, more preferably from about 0.05% to about 10%, most preferably from about 0.1% to about 5%, by weight of the cationic polymer of the coacervate forming composition .

A wide variety of anionic surfactants are suitable for use in the compositions of the present invention. See, for example, U.S. Patent No. 2,929,678 [Laughlin et al., Issued December 30, 1975]. Non-limiting examples of anionic surfactants include acyl isethionates (e.g., C ₁₂ -C ₃₀ ), alkyl and alkyl ether sulfates and salts thereof, alkyl and alkyl ether phosphates and salts thereof, alkylmethyltaurates For example C ₁₂ -C ₃₀ ), fatty acid soaps (for example alkali metal salts such as sodium or potassium salts) and monoalkanolamine phosphates. Preferably, for the coacervate-forming composition, the anionic surfactant is selected from the group consisting of sarcosinate, glutamate, sodium alkyl sulfate, ammonium alkyl sulfate, sodium alkylate sulfate, ammonium alkylate sulfate, ammonium laureth- Sulfates, sulfates, sodium laureth-n-sulfates, isethionates, glyceryl ether sulfonates, sulfosuccinates, monoalkanolamine phosphates, and combinations thereof. More preferably, the anionic surfactant is selected from the group consisting of sodium lauroyl sarcosinate, monosodium lauroyl glutamate, sodium alkyl sulfate, ammonium alkyl sulfate, sodium alkylate sulfate, ammonium alkylate sulfate, Amine phosphates, and combinations thereof.

Suitable coacervate-forming compositions are also described in co-pending U.S. Patent Application Serial No. 09 / 397,747 (Schwartz et al.), Filed Sep. 16, 1999; 09 / 397,746 (Heinrich et al.); 09 / 397,712 (Schwartz et al.); 09 / 397,723 (Heinrich et al.); 09 / 397,722 (Venkitaraman et al.).

Alternatively, the coacervate-forming composition may contain a dermatologically acceptable carrier for a cationic polymer, a cationic surfactant, and a polymer and a surfactant. The anionic polymers may be selected from the group consisting of polyacrylic acid polymers, polyacrylamide polymers, copolymers of acrylic acid, acrylamide, and other natural or synthetic polymers (e.g., polystyrene, polybutene, polyurethane, ≪ / RTI > and combinations thereof. Suitable gums include alginates (e.g., propylene glycol alginate), pectin, chitosan (e.g., chitosan lactate), and modified gums (such as starch octenyl succinate), and combinations thereof. More preferably, the anionic polymer is selected from the group consisting of polyacrylic acid polymers, polyacrylamide polymers, pectin, chitosan, and combinations thereof. Preferred articles of the present invention comprise from about 0.01% to about 20%, more preferably from about 0.05% to about 10%, most preferably from about 0.1% to about 5%, by weight of the anion- Lt; / RTI > Suitable cationic surfactants include, but are not limited to those discussed herein.

The absence of the therapeutic efficacy of the article may cause the skin or hair to have an effect on the skin as well as a conditioning agent as well as an anti-acne agent, anti-wrinkle agent, antimicrobial agent, antifungal agent, anti- inflammatory agent, topical anesthetic, artificial tanning agent and accelerator, Such as, but not limited to, antioxidants, skin exfoliants, and combinations thereof, to provide therapeutic or aesthetic benefits.

It is also to be understood that the absence of therapeutic efficacy may be contained within the cleansing component of the present invention, or vice versa, to form a single component with an indiscernible inclusion.

Surface versus saturation non-methodology

The articles of the present invention contain substantially no therapeutic benefit on the surface of the substrate. The expression " substantially on the surface of the substrate " means that the surface saturation ratio is greater than about 1.25, preferably greater than about 1.5, more preferably greater than about 2.0, even more preferably greater than about 2.25, . The surface saturation ratio is a measure of the benefit formulation on the surface of the substrate. These measurements were obtained using an Attenuated Total Reflectance (ATR) FT-IR spectrometer well known to those skilled in the art of analytical chemistry.

Many existing methods of applying conditioning agents to substrates utilize process and / or product rheology unsuitable for the purposes of the present invention. As an example, a so-called " dip and nip " process, in which a substrate web is immersed in a fluid bath of a conditioning agent and then the substrate web is pressed through a metering roll, , There is no opportunity for effective direct delivery of the composition out of the fabric and onto other surfaces during use. In addition, many of the articles of the present invention provide effective overall body benefits using sufficient loading of the conditioning agent onto the substrate, which generally requires a loading rate of about 100% to 200% based on the dry substrate weight . Known personal care tools that take advantage of this high loading level essentially avoid coping with aesthetic problems that can result from high loading by distributing the loading uniformly throughout the substrate, including inside the substrate. Applicants have surprisingly found that a high loading conditioning agent can be retained on the surface of the article and thus the opportunity of direct delivery of the benefit agent from the substrate to the treated surface during use can be advantageously met, Thereby providing improved aesthetics.

The measurement procedure is as follows.

Instrument set-up : A BioRad FTS-7 spectrometer from Bio Rad Labs, Cambridge, MA, Digital Laboratory Division, MA, was used to collect infrared spectra. Typically, 100 scans were measured at a resolution of 4 cm ^-1 . The collection optics are Graseby Specac, Inc. (Located in the CT pair field) of a flat 60 degree ZnSe ATR crystal. Data were collected at 25 < 0 > C and analyzed by Galactic Industries Corp. (Located in Salem, NH) using Grams 386 software. Before measurement, the crystals were washed with an appropriate solvent. The sample was placed in the ATR crystalline phase and held under a constant 4 kg weight.

Experimental Procedure

(1) Measure the reference (background) spectrum of cleaned and air dried cells.

(2) First, a substrate to which the benefit formulation is not applied is selected, and the selected substrate constitutes the outer surface of the article. ATR crystals, place the substrate on top of the outer surface for crystallization. First, the substrate is placed flat on the measuring platform. Thereafter, a weight of 4 kg is placed on the substrate. The spectrum is then measured (typically 100 scans at 4 cm ^-1 resolution). Since the absorbance of the substrate alone is confirmed, the substrate functions as an internal standard. Check the major base peaks and wavelengths.

(3) Repeat the process for the description of the article to which the benefit formulation is applied. Does not correspond to the same base peaks as previously observed; Or the peak height of the primary benefit formulation which corresponds to the previously observed base peak but which is the highest observation peak showing a significant percentage increase in absorbance due to the presence of the conditioning agent. Record the wavelength number and absorbance of some benefit formulation peaks.

(4) From the spectrum determined in the third step, a base peak which is generated at the wavelength number determined in the second step but does not correspond to one of the primary benefit agent peaks selected in the third step is selected. Record the wavelength number and the absorbance selected from the absorption spectrum of the third step.

(5) For the peak height of the substrate determined in step 4, calculate the ratio of the peak height of each benefit formulation determined in step 3. The highest number of groups represents the surface saturation ratio of the article.

The following includes some examples:

Description * Base Peak and Peak Height conditioner for hair Conditioner peak height ratio Betting (a blend of thermally bonded polyester with 70% PET / PE bicomponent fibers) 0.0865 (C = O peak at 1710 cm ^-1 ) Glycerin (CO peak at 1030 cm ^-1 ) 0.181 2.09 Betting (a blend of thermally bonded polyester with 70% PET / PE bicomponent fibers) 0.0865 (C = O peak at 1710 cm ^-1 ) Hydrocarbons (CH peak at 2923 cm ^-1 ) 0.160 1.85 Wet tangled 70% rayon / 30% polyester 0.0333 (C = O peak at 1710 cm ^-1 ) Glycerin (CO peak at 1030 cm ^-1 ) 0.0684 2.05

* This type of substrate is readily available, for example, from PGI Nonwovens (Benson, NC).

Water conservancy methodology

As described above, the articles of the present invention are considered to be " substantially dry ". The expression " substantially dry ", as used herein, means that the articles of the present invention exhibit less than about 0.95 gms, preferably less than about 0.75 gms, more preferably less than about 0.5 gms, more preferably less than about 0.25 gms, Means a water holding capacity of less than about 0.15 gms, and most preferably less than about 0.1 gms. The water holding capacity is a measure of dry feeling as opposed to a " wet " towel feel when users touch the article of the present invention.

In order to determine the water holding capacity of products based on the present invention and other disposable substrates, the following equipment and materials are required.

Bounty White Paper Towel Procter & Gamble SKU37000 63037 basis weight = 42.14gsm Scale Adjust to exactly 0.0g Lexan 0.5 " thick < / RTI > sufficiently large to completely cover the sample, Weight 2000g weight or even combination to 2000g

Then, weigh each two paper towels and record them. Place a piece of paper towel on a flat surface (for example, a laboratory bench). The sample article is placed on the towel. Place another piece of paper towel on top of the sample item. Then place Lexan and place 2000g weight (s) on the sandwiched sample article. Wait one minute. After one minute, remove the weight (s) and Lexan. Weigh the paper towel on the top and bottom of the sample and record the weight.

For both the top and bottom paper towels, subtract the initial paper towel weight from the final weight (after one minute) to calculate the water holding capacity. The weight differences obtained for the paper towels on the top and bottom are summed. Assuming that a number of items have been tested, calculate the water holding capacity by averaging the total weight differences.

Example of composite product implementation

The article of the present invention may also be packaged with additional items suitable for providing benefits of a separate benefit, e.g., cosmetic, therapeutic, functional, etc., that are not individually or provided by the primary article, have. Additional articles of such personal care kits preferably contain a water insoluble substrate comprising one or more layers and a cleansing component containing a therapeutic active ingredient or a foam-forming surfactant disposed or impregnated in a base layer of the additional article .

The additional articles of the present invention may also provide functional benefits in addition to or in place of therapeutic or cosmetic benefits. By way of example, the additional article can be used as a drying tool suitable for being used to help remove water from the skin or hair after the shower or bath is over.

Multi-Chamber Implementation Example

The articles of the present invention may include one or more chambers. These chambers or compartments are due to the connection (e.g., bonding) of the other layers to the substrate layers at various locations, which limits the enclosed area. Such chambers are useful, for example, for separating various article members, such as surfactant-containing cleansing ingredients and conditioning agents. Separate article members that provide therapeutic or cosmetic or cleansing benefits may be provided to the chamber by any means known in the art including, but not limited to, solubilization, emulsification, mechanical transfer, puncturing, popping, rupturing, squeezing, And may be released from the chambers in a variety of ways, including peeling of the substrate layer.

Arbitrary member

The articles of the present invention may contain various other elements commonly used in certain product forms, provided that they do not unintentionally alter the benefits of the present invention. It will be appreciated that the optional components should be suitable for application to human skin and hair, i.e., when incorporated into an article, they may be administered to humans and / or human beings within a sound medical or formulator's judgment without undue toxicity, incompatibility, instability, It should be suitable for use in contact with the skin. The CTFA Cosmetic Ingredient Handbook, Second Edition (1992) describes a wide variety of non-limiting cosmetic and pharmaceutical ingredients commonly used in the skin care industry, suitable for use in the articles of the present invention. Examples of the component group include: enzymes, abrasives, skin exfoliants, absorbents, cosmetic ingredients such as fragrances, pigments, colorants / colorants, essential oils, skin sensitizers, astringents and the like Antiseptic agents (e.g., resorcinol, sulfur, salicylic acid, erythromycin, zinc, etc.), antioxidants (e. G., Oils, menthol, camphor, eucalyptus oil, eugenol, menthyl lactate, Anti-oxidants, binders, biological additives, buffering agents, bulking agents, chelating agents, chemical additives, coloring agents, cosmetic astringents (for example, anti-foaming agents) , Polymers for assisting film-forming properties and realities of compositions, such as cosmetic biocides, modifiers, drug astringents, external analgesics, film formers or materials, such as polymers of eicosene and vinylpyrrolidone(For example, hydroquinone, kojic acid, ascorbic acid, magnesium ascorbyl phosphate, ascorbyl glucosamine), wetting agents, opacifying agents, pH adjusting agents, propellants, reducing agents, quenchers, , Panthenol and derivatives (e.g., ethyl panthenol), aloe vera, pantothenic acid and its derivatives, allantoin, bisabolol, and dipotassium glycyrrhizinate), skin wrinkles (E. G., Alpha-hydroxy acids such as lactic acid and glycolic acid and beta-hydroxy acids such as salicylic acid), thickeners, hydrocolloids, Zeolites, and vitamins and derivatives thereof such as tocopherol, tocopherol acetate, beta carotene, retinoic acid, retinol, retinoids, retinyl palmitate, niacin, Niacinamide, etc.). The article of the present invention may comprise a carrier member known in the art. The carrier may comprise one or more miscible liquids or solid filler diluents or Vecich, suitable for application to the skin or hair.

The article of the present invention may optionally comprise one or more of said optional members. Preferred articles are, optionally, vitamins, skin treatments, anti-acne activators, anti-wrinkle activators, anti-skin atrophy activators, anti-inflammatory actives, topical anesthetics, artificial tanning activators and accelerators, antimicrobial activators, An effective amount of a therapeutic benefit comprising a therapeutically effective agent selected from the group consisting of anti-fungal agents, anti-fungal agents, sunscreen actives, anti-oxidants, skin exfoliants, and combinations thereof. As used herein, a " safe effective amount " is sufficient to significantly induce a positive effect or benefit, but is sufficiently low to avoid serious side effects (e.g., excessive toxicity or allergic response) ≪ RTI ID = 0.0 > and / or < / RTI >

Any member useful herein may be categorized by the therapeutic or aesthetic benefit of the action or by its assumed mode. However, any member useful herein may, in some instances, provide one or more therapeutic or aesthetic benefits or act through one or more forms of action. Thus, the classifications herein are for convenience only and are not intended to limit the ingredients for any particular application or listed application. Also, where applicable, pharmaceutically acceptable salts of the components are useful herein.

Anionic polymer

The articles of the present invention may optionally contain anionic polymers. Suitable anionic polymers include, but are not limited to, polyacrylic acid polymers, polyacrylamide polymers, copolymers of acrylic acid, acrylamide, and other natural or synthetic polymers such as polystyrene, polybutene, polyurethane, A combination thereof, and the like. Suitable gums include alginates (e.g., propylene glycol alginate), pectin, chitosan (e.g., chitosan lactate), and modified gums (such as starch octenyl succinate), and combinations thereof.

Vitamin compound

The articles of the present invention may contain vitamin compounds, precursors, and derivatives thereof. These vitamin compounds may be in natural or synthetic form. Examples of suitable vitamin compounds include vitamin A (e.g., beta carotene, retinoic acid, retinol, retinoid, retinyl palmitate, retinyl propionate and the like), vitamin B (e.g., niacin, niacinamide, riboflavin, pantothenic acid, Vitamin E (e.g., tocopherol acetate, etc.), vitamin K (e.g., phytonadione, Mena, etc.), vitamin C (e.g., ascorbic acid and the like), vitamin D (e.g., ergosterol, ergocalciferol, cholecalciferol, Dione, petiolecol, etc.) compounds.

In particular, the article of the present invention may contain a vitamin B ₃ compound in an effective amount of safety. Vitamin B ₃ compounds, the whole being, co-pending, which is reflected by reference in its entirety U.S. Patent Application Serial No. 08 / No. 834 010 (filed April 11, 1997) (International Publication No. WO 97/39733 A1 (October 1997 Quot ;, published on May 30, 1999). The therapeutic member of the present invention preferably comprises from about 0.01% to about 50%, more preferably from about 0.1% to about 10%, even more preferably from about 0.5% to about 10%, even more preferably from about 1% to about 5%, and most preferably the vitamin B ₃ compound of from about 2% to about 5%.

Herein, "vitamin B ₃ compound" used is a compound having the formula to; Derivatives thereof; And salts of any of the foregoing:

Wherein R is -CONH ₂ (i.e., niacinamide), -COOH (i.e., nicotinic acid), or -CH ₂ OH (i.e., nicotinyl alcohol).

Examples of the derivatives of the above-mentioned vitamin B ₃ compounds include nicotinic acid esters including non-vasodilating esters of nicotinic acid, nicotinyl amino acid, nicotinyl alcohol ester of carboxylic acid, nicotinic acid N-oxide and niacinamide N-oxide .

Examples of suitable vitamin B ₃ compounds are well known in the art, a number of sources, e.g., Sigma Chemical Company (St. Louis, MO ); ICN Biomedicals, Inc. (Irvin, Calif.) And Aldrich Chemical Company (Milwaukee, Wis.)

Vitamin compounds can be included as a substantially pure material or as an extract obtained by suitable physical and / or chemical isolation from a natural (e.g., plant) source.

Skin Treatment

The article of the present invention may contain one or more skin treatment agents. Suitable skin treatment agents include those effective for preventing, delaying, inhibiting, and / or reversing skin wrinkles. Examples of suitable skin treatment agents include, but are not limited to, alpha-hydroxy acids such as lactic acid and glycolic acid and beta-hydroxy acids such as salicylic acid.

Anti acne agent

Examples of anti-acne agents useful in the article of the present invention include keratolytic agents such as salicylic acid (o-hydroxybenzoic acid), derivatives of salicylic acid such as 5-octanoylsalicylic acid, and resorcinols; Retinoids such as retinoic acid and derivatives thereof (e.g., cis and trans); Sulfur-containing D and L amino acids and their derivatives and salts, especially their N-acetyl derivatives, preferred examples include N-acetyl-L-cysteine; Lipoic acid; Antibiotics and antimicrobial agents such as benzoyl peroxide, octopirox, tetracycline, 2,4,4'-trichloro-2'-hydroxydiphenyl ether, 3,4,4'-trichlorobanilide , Azelaic acid and its derivatives, phenoxyethanol, phenoxypropanol, phenoxyisopropanol, ethyl acetate, clindamycin and mecocycline; Sebostat, such as flavonoids; And bile acid salts such as scymnol sulfate and derivatives thereof, deoxycholate, and cholate.

Anti-wrinkle agent and anti-skinning agent

Examples of wrinkle preventing agents and skin irritation preventing agents useful in the articles of the present invention include retinoic acid and derivatives thereof (e.g., cis and trans); Retinol; Retinyl ester; Niacinamide, salicylic acid and derivatives thereof; Sulfur-containing D and L amino acids and their derivatives and salts, especially N-acetyl derivatives, preferred examples of which include N-acetyl-L-cysteine; Thiols, such as ethanethiol; Hydroxysic acid, phytic acid, lipoic acid; Lysophosphatidic acid, and skin exfoliation agents (e.g., phenol and the like).

Non-steroidal anti-inflammatory drugs (NSAIDS)

Examples of NSAIDS useful in the articles of the present invention include, but are not limited to, the following categories: propionic acid derivatives; Acetic acid derivatives; Phenanic acid derivatives; Biphenylcarboxylic acid derivatives; And oxycam. All of these NSAIDS are fully described in U.S. Patent No. 4,985,459 (Sunshine et al., Issued January 15, 1991), which is incorporated herein by reference in its entirety. Examples of useful NSAIDS include, but are not limited to, acetylsalicylic acid, ibuprofen, naproxen, beroxaprofen, fluulbifropen, fenoprofen, penbufen, ketoprofen, indoprofen, , Pranoprofen, miroprofen, thioxaprofen, suroprofen, alminopropone, thiopropenoic acid, fluprofen and bacloxacan. Steroidal anti-inflammatory drugs including hydrocortisone and the like are also useful.

Local anesthetic

Examples of topical anesthetics useful for the articles herein include but are not limited to benzocaine, lidocaine, bupivacaine, chlorprocaine, dibucaine, etidocaine, mephvacaine, tetracaine, dichlonine, hexylcaine, procaine, cocaine, Ketamine, pramoxine, phenol, and pharmaceutically acceptable salts thereof.

Artificial tanning and accelerating agents

Examples of artificial tanning agents and promoters useful in the articles of the present invention include, but are not limited to, tyrosine esters such as dihydroxyacetone, tyrosine, ethyl tyrosinate, and phospho-DOPA.

Antimicrobial agent and antifungal agent

Examples of antimicrobial agents and antifungal agents useful in the articles of the present invention include, but are not limited to,? -Lactam drugs, quinolone drugs, ciprofloxacin, norfloxacin, tetracycline, erythromycin, amikacin, 2,4,4'- trichloro- But are not limited to, carboxymethylcellulose, hydroxypropylmethylcellulose, hydroxypropylmethylcellulose, hydroxypropylmethylcellulose, hydroxypropylmethylcellulose, hydroxypropylmethylcellulose, hydroxypropylmethylcellulose, hydroxypropylmethylcellulose, hydroxypropylmethylcellulose, hydroxypropylmethylcellulose, hydroxypropylmethylcellulose, hydroxypropylmethylcellulose, , Hexamidine, isethionate, metronidazole, pentamidine, gentamicin, kanamycin, linemmaicin, methacycline, methenamine, minocycline, neomycin, nethymicin, paromomycin, streptomycin, tobramycin, Tetracycline hydrochloride, erythromycin, zinc erythromycin, erythromycin esters, erythromycin But are not limited to, stearates, amikacin sulfate, doxycycline hydrochloride, capreomycin sulfate, chlorhexidine gluconate, chlorhexidine hydrochloride, chloretetracycline hydrochloride, oxytetracycline hydrochloride, clindamycin hydrochloride, ethambutol hydrochloride, metronidazole hydrochloride , Pentamidine hydrochloride, gentamicin sulfate, kanamycin sulfate, lincomycin hydrochloride, methacyline hydrochloride, methenamine hydrochloride, methenamine mandelate, minocycline hydrochloride, neomycin sulfate, , Paromomycin sulfate, streptomycin sulfate, tobramycin sulfate, myconezole hydrochloride, amanpadine hydrochloride, amanfadine sulphate But are not limited to, lactose, pectin, octopirox, parachlorometazolyl, nystatin, tolnaphthate, zinc pyrithione and clotrimazole.

Antiviral agent

The article of the present invention may further contain one or more antiviral agents. Suitable antiviral agents include, but are not limited to, metal salts such as silver nitrate, copper sulfate, iron chloride, and organic acids such as malic acid, salicylic acid, succinic acid, benzoic acid and the like. In particular, compositions containing additional suitable antiviral agents include co-pending U.S. Patent Application Serial No. 09 / 421,084 (Beerse et al.), Filed Oct. 19, 1999; 09 / 421,131 (Biedermann et al.); 09 / 420,646 (Morgan et al.); And 09 / 421,179 (Page et al.).

enzyme

The article of the present invention may optionally comprise one or more enzymes. Preferably, such enzymes are dermatologically acceptable. Suitable enzymes include, but are not limited to, keratinase, protease, amylase, subtilisin, and the like.

Sunscreen

Sunscreens are also useful here. A wide variety of sunscreen agents are described in U.S. Patent No. 5,087,445 [Haffey et al., Issued February 11, 1992], both of which are incorporated herein by reference in their entirety; U.S. Patent No. 5,073,372 [Turner et al., Issued December 17, 1991]; U.S. Patent No. 5,073,371 [Turner et al., Issued December 17, 1991]; And Segarin et al., Cosmetics Science and Technology, VIII chapter, p. 189 < / RTI > Non-limiting examples of sunscreen agents useful in the compositions of the present invention include 2-ethylhexyl p -methoxy cinnamate, 2-ethylhexyl N, N-dimethyl- p- aminobenzoate, p- aminobenzoic acid, Methoxy-t-butyldibenzoylmethane, 4-isopropyldibenzoylmethane, 3- (4-methoxyphenyl) benzoylmethane, 3- There are those selected from the group consisting of benzylidene camphor, 3- (4-methylbenzylidene) camphor, titanium dioxide, zinc oxide, silica, iron oxide, and mixtures thereof. Other useful sunscreen agents include U.S. Patent No. 4,937,370 [Sabatelli, issued June 26, 1990]; And U.S. Patent No. 4,999,186 (Sabatelli et al., Issued March 12, 1991), both of which are incorporated herein by reference in their entirety. Particularly preferred examples of such sunscreen agents include 4-N, N- (2-ethylhexyl) methylaminobenzoic acid ester of 2,4-dihydroxybenzophenone, 4-N, N- (2-ethylhexyl) methylaminobenzoic acid ester, 4-N, N- (2-ethylhexyl) methylaminobenzoic acid ester, 4- (2-ethylhexyl) 4-N, N- (2-ethylhexyl) -methylaminobenzoic acid ester of dibenzoylmethane and dibenzoylmethane, and mixtures thereof. The exact amount of sunscreen agent that can be used will depend on the sunscreen chosen and the sunscreen desired to be achieved (SPF). SPF is a commonly used light protection measure of sunscreen for erythema. Which is incorporated herein by reference in its entirety [ Federal Register , Vol. 43, No. 166, pp. 38206 to 38269, August 25, 1978].

Hydrocolloid

Hydrocolloids may also optionally be included in the article of the present invention. Hydrocolloids are well known in the art and aid in extending the useful life of the surfactants contained within the cleansing components of the present invention so that the article can last for at least one full shower or bath. Suitable hydrocolloids include xanthan gum, carboxymethyl cellulose, hydroxyethyl cellulose, hydroxylpropyl cellulose, methyl and ethyl cellulose, natural rubbers, gudras guar gum, soybean gum, natural starch, deionized starch ( Starch octenyl succinate), and the like, but are not limited thereto.

Pyrogenic zeolite

Zeolites and other compounds which exothermally react when combined with water may also optionally be included in the article of the present invention.

Structured Conditioning Agents

The article of the present invention may optionally contain a structured conditioning agent. Suitable structured conditioning agents include, but are not limited to, vesicular structures such as ceramides, liposomes, and the like.

Hydrogel-forming polymeric gelling agent

In certain embodiments of the invention, the article may optionally contain an aqueous gel, i.e., " hydrogel " formed from a hydrogel-forming polymeric gelling agent and water. More specifically, the hydrogel is contained within the cleansing component or therapeutic efficacy component of the article. In the presence of the aqueous gel, the article is preferably present in an amount of from about 0.1% to about 100% by weight, more preferably from about 3% to about 50% by weight, most preferably from about 5% 35% by weight of a hydrogel-forming polymeric gellant based on the dry weight of the hydrogel-forming polymeric gellant.

Generally, the hydrogel-forming polymeric gellant material of the present invention is an at least partially crosslinked polymer made from polymerizable unsaturated acid-containing monomers which become water-soluble or hydrolytically soluble. These include monoethylenically unsaturated compounds having at least one hydrophilic radical, including, but not limited to, olefinically unsaturated acids and anhydrides comprising at least one carbon-carbon olefinic double bond. In these monomers, water solubility means that the monomers are dissolved in deionized water at a level of 0.2% or more, preferably 1.0% or more at 25 占 폚.

In the polymerization, the monomeric units as mentioned above generally contain from about 25 mol% to 99.99 mol%, more preferably from about 50 mol% to 99.99 mol%, most preferably at least about 75 mol% of the polymeric gellant material Phosphorus (based on the dry weight of the polymer), acid-containing monomers.

Wherein the hydrogel-forming polymeric gellant is preferably partially crosslinked to an extent that is sufficiently high that the resulting polymer does not exhibit a glass transition temperature (Tg) of less than about 140 캜, and therefore the term A " hydrogel-forming polymeric gellant " will refer to a polymer that satisfies these parameters. Preferably, the hydrogel-forming polymeric gellant has no Tg at less than about 180 DEG C, and more preferably no Tg at temperatures above about 300 DEG C prior to decomposition of the polymer. The Tg can be measured by differential scanning calorimetry (DSC) using a sample of 5 mg or less and a heating rate of 20.0 DEG C / min. Tg is calculated as the midpoint between the start point and the end point of the heat flow change corresponding to the glass transition on the DSC heat capacity heating curve. The use of DSC to determine Tg is well known in the art, see [B. Cassel and MP DiVito, " Use of DSC To Obtain Accurate Thermodynamic and Kinetic Data ", American Laboratory, January 1994, pp. 14-19; Wunderlich, Thermal Analysis , Academic Press, Inc., 1990).

The hydrogel-forming polymeric material is characterized as a highly absorbent and can retain water in an absorbed or " gel " state. Here, the preferred hydrogel-forming polymeric gelling agent is capable of absorbing at least about 40 grams of water (deionized water) per gram of gelling agent, preferably at least about 60 grams per gram, more preferably at least about 80 grams per gram There will be. These values, referred to herein as " absorbent capacity ", can be measured according to the procedure in the absorbent capacity " tea bag " test described above.

Wherein the hydrogel-forming polymeric gellant will generally be at least partially crosslinked. Suitable crosslinking agents are well known in the art and include, for example, (1) compounds having two or more polymerizable double bonds; (2) a compound having at least one polymerizable double bond and at least one functional group reactive with an acid-containing monomer material; (3) a compound having at least two functional groups which are reactive with an acid-containing monomer material; And (4) a polyvalent metal compound capable of forming an ionic crosslinked portion.

Crosslinking agents having two or more polymerizable double bonds include (i) di- or polyvinyl compounds such as divinylbenzene and divinyltoluene; (ii) a di- or triacrylate ester of a polyol such as, for example, ethylene glycol, trimethylol propane, glycerine, or polyoxyethylene glycol, and a di- or polyester of an unsaturated mono- or polycarboxylic acid ; (iii) bisacrylamides such as N, N-methylenebisacrylamide; (iv) a carbamyl ester which can be obtained by reacting a polyisocyanate with a hydroxyl group-containing monomer; (v) di- or polyallyl ethers of polyols; (vi) di- or polyallyl esters of polycarboxylic acids such as diallyl phthalate, diallyl adipate and the like; (vii) esters of monoallyl esters of polyols with unsaturated mono- or polycarboxylic acids, such as acrylic acid esters of polyethylene glycol monoallyl ether; And (viii) di- or triallylamine.

Crosslinking agents having at least one polymerizable double bond and at least one functional group reactive with the acid-containing monomer material include N-methylol acrylamide, glycidyl acrylate, and the like. Suitable crosslinking agents having two or more functional groups reactive with the acid-containing monomeric material include glyoxal; Polyols such as ethylene glycol and glycerol; Polyamines such as alkylenediamines (e.g., ethylenediamine), polyalkylene polyamines, polyepoxides, di- or polyglycidyl ethers, and the like. Suitable multivalent metal bridging agents capable of forming ionic bridges include, for example, oxides, hydroxides and weak acid salts of alkaline earth metals (e.g., calcium, magnesium) and zinc, including calcium oxide and zinc diacetate , Carbonates, acetates, etc.).

Many of the above-described types of crosslinking agents are described in more detail in U.S. Patent No. 4,076,663 (Masuda et al., Issued Feb. 28, 1978) and U.S. Patent No. 4,861,539 (Allen et al., Issued Aug. 29, 1989) , Both of which are incorporated herein by reference. Preferred crosslinking agents include di- or polyesters of unsaturated mono- or polycarboxylic acid monoallyl esters of polyols, bisacrylamides, and di- or triallyl amines. Specific examples of particularly preferable crosslinking agents include N, N'-methylenebisacrylamide and trimethylolpropane triacrylate.

The crosslinking agent will generally comprise from about 0.001 mole percent to about 5 mole percent of the resulting hydrogel-forming polymeric material. More generally, the cross-linking agent will comprise from about 0.01 mole percent to about 3 mole percent of the hydrogel-forming polymeric gellant used.

Wherein the hydrogel-forming polymeric gellant can be used in a partially neutralized form. For purposes of the present invention, such materials are considered to be partially neutralized if at least 25 mole%, preferably at least 50 mole% of the monomers used in polymer formation are acid group-containing monomers neutralized with a base. Suitable neutralizing base cations include alkali and alkaline earth metal hydroxides (e.g., KOH, NaOH), ammonium, substituted ammonium, and amino alcohols such as 2-amino- Amine, and 2-amino-2-methyl-1-propanol). The percentage of total monomers used, which are neutralized acid group containing monomers, is referred to herein as " neutralization degree ". The degree of neutralization will preferably not exceed 98%.

Hydrogel-forming polymeric gelling agents suitable for use herein are well known in the art and include, for example, U.S. Pat. No. 4,076,663 [Masuda et al., Issued February 28, 1978]; U.S. Patent No. 4,062,817 [Westerman, issued December 13, 1977]; U.S. Patent No. 4,286,082 [Tsubakimoto et al., Issued Aug. 25, 1981]; U.S. Patent No. 5,061,259 [Goldman et al., Issued October 29, 1991]; And U.S. Patent No. 4,654,039 [Brandt et al., Issued March 31, 1987], each of which is incorporated herein by reference in its entirety.

Suitable hydrogel-forming polymeric gelling agents for use herein are also described in U.S. Patent No. 4,731,067 [Le-Khac, issued March 15, 1988], U.S. Patent No. 4,743,244 [Le-Khac, issued May 10, 1988 U.S. Patent No. 4,813,945 [Le-Khac, issued March 21, 1989], U.S. Patent No. 4,880,868 [Le-Khac, issued November 14, 1989], U.S. Patent No. 4,892,533 [Le-Khac, U.S. Patent No. 5,026,784 [Le-Khac, issued June 25, 1991], U.S. Patent No. 5,079,306 [Le-Khac, issued January 7, 1992] U.S. Patent No. 4,861,539 [Allen, Farrer, and Flesher, issued Aug. 29, 1989], and U.S. Patent No. 4,962,172 [Allen, Farrer, et al. Flesher, Oct. 9, 1990, each of which is incorporated herein by reference in its entirety.

Suitable hydrogel-forming polymeric gelling agents in particulate form are available from Hoechst Celanese Corporation (Portsmouth, VA, USA) (Sanwet ^TM superabsorbent polymer), Nippon Shokubai, Japan (Aqualic ^TM , And Dow Chemical Company (Midland, MI, USA) (Dry Tech ^TM ).

Hydrogel-forming polymeric gellants in the form of fibers are commercially available from Camelot Technologies Inc. (Leominster, MA, USA) (Fibersorb ^TM , such as SA 7200H, SA 7200M, SA 7000L, SA 7000, and SA 7300).

The article of the present invention may also contain other hydrophilic gelling agents. These include carboxylic acid-containing polymers such as those described above, as well as a variety of other water-soluble or colloidal water-soluble polymers such as cellulose ethers (e.g., hydroxyethylcellulose, methylcellulose, methylcellulose, Hydroxypropylmethylcellulose), polyvinylpyrrolidone, polyvinyl alcohol, guar gum, hydroxypropyl guar gum, and xanthan gum. Among these additional hydrophilic gelling agents, preferred are acid-containing polymers, especially carboxylic acid-containing polymers. Particularly preferred are those comprising a water-soluble polymer of a polyalkenyl polyether of a polyhydric alcohol and a crosslinked acrylic acid, and optionally an acrylate ester or a polyfunctional vinylidene monomer.

Preferred copolymers useful in the present invention comprise from 95% to 99% by weight of an olefinically unsaturated carboxylic monomer selected from the group consisting of acrylic acid, methacrylic acid and ethacrylic acid; From about 1% to about 3.5% by weight of an acrylate ester of the formula:

(Wherein R is an alkyl radical having 10 to 30 carbon atoms, and R < ₁ > is hydrogen, methyl or ethyl); And a polymerizable crosslinked polyalkenyl polyether having at least one alkenyl ether group per molecule (the parent polyhydric alcohol containing at least 3 carbon atoms and at least 3 hydroxyl groups) in an amount of 0.1 to 0.6 By weight, based on the total weight of the composition.

Preferably, these polymers contains an acrylate ester of about 96% to acrylic acid and from about 2.5% to about 3.5% by weight to approximately 97.9% by weight, where the alkyl group has carbon atoms of 12 to 22, R ₁ is methyl And most preferably, the acrylate ester is stearyl methacrylate. Preferably, the amount of crosslinked polyalkenyl polyether monomer is from about 0.2% to 0.4% by weight. Preferred crosslinked polyalkenyl polyether monomers are allylpentaerythritol, trimethylolpropane diallyl ether, or allyl sucrose. These polymers are fully described in U.S. Patent No. 4,509,949 [Huang et al., Issued April 5, 1985], which is incorporated herein by reference.

Another preferred copolymer useful in the present invention is a polymer containing two or more monomeric components, one of which is a monomeric olefinically unsaturated carboxylic acid and the other is a polyalkenyl polyether of a polyhydric alcohol. If desired, additional monomeric materials may be present in the monomeric mixture, even in predominant proportions.

The first monomeric component useful for the production of the carboxyl polymer is an olefinically unsaturated carboxylic acid containing at least one activated carbon-carbon olefinic double bond and at least one carboxyl group. Preferred carboxyl monomers are acrylic acids having the following general formula:

(Wherein R ² is a substituent selected from the group consisting of hydrogen, halogen, and a cyanogen (-C═N) group, a monovalent alkyl radical, a monovalent alkaryl radical, and a monovalent cycloaliphatic radical. Of these classes, acrylic acid, methacrylic acid, and ethacrylic acid are most preferred. Another useful carboxyl monomer is maleic anhydride or maleic acid. The amount of acid used will be from about 95.5 wt.% To about 98.9 wt.%.

A second monomeric component useful in the formation of these carboxyl polymers is a monomeric component in which the olefinic double bond has more than one alkenyl ether group per molecule, such as an alkenyl group attached to the terminal methylene group CH ₂ = C < Polyalkenyl polyether.

With additional monomeric materials which may be present in the polymers, such as butadiene, isoprene, divinyl benzene, divinyl naphthyl teulren, allyl-containing acrylate, at least two terminal CH ₂ <polyfunctional vinylidene group-containing Monomers are included. Such polymers are fully described in U.S. Patent No. 2,798,053 [Brown, 2 July 1957], which is incorporated herein by reference in its entirety.

Examples of carboxylic acid copolymers useful in the present invention include Carbomer 934, Carbomer 941, Carbomer 950, Carbomer 951, Carbomer 954, Carbomer 980, Carbomer 981, Carbomer 1342, Acrylate / C10-30 alkyl acrylate cross polymer (Carbopol 934, Carbopol 941, Carbopol 950, Carbopol 951, Carbopol 954, Carbopol 980, Carbopol 981, Carbopol 1342, and Pemulen series, each available from BF Goodrich).

Other carboxylic acid copolymers useful in the present invention include sodium salts of acrylic acid / acrylamide copolymers sold by the Hoechst Celanese Corporation under the tradename Hostaceren PN73. Also included are hydrogel polymers sold by Lipo Chemicals Inc. under the trade name HYPAN hydrogel. These hydrogels consist of crystalline flicks of nitrate on the C-C main chain with various other pendant groups such as carboxyl, amide, and amidine. An example of this would be HYPAN SA 100 H, a polymer powder available from Lipo Chemical.

Neutralizing agents used to neutralize the acid groups of these polymers include those described above.

Cleansing ingredient

The article of the present invention may optionally contain a cleansing component that additionally contains one or more surfactants. The cleansing component is disposed adjacent to the nonwoven layer of the water-insoluble substrate. The articles of the invention contain from about 10% to about 1,000%, preferably from about 50% to about 600%, more preferably from about 100% to about 250%, of a surfactant, based on the weight of the water-insoluble substrate. In addition, the articles of the present invention preferably contain at least about 1 g of surfactant based on the weight of the water-insoluble substrate. Thus, the cleansing component can be added to the substrate without the need for a drying process.

The surfactant of the cleansing component is preferably a foam-forming surfactant. As used herein, " lathering surfactant " refers to a surfactant that, when combined with water to produce a foam or lather when mechanically stirred. Such surfactants are preferred because increased foam is important to consumers as an indication of the cleansing effect. In certain embodiments, the combination of surfactant or surfactant is mild. As used herein, the expression " mild " means that the article of the present invention, as well as the surfactant, will comprise at least, typically, a natural soap and a synthetic surfactant (e. And Zest &Lt; / RTI &gt; of a conventional bar soap matrix containing a combination of &lt; RTI ID = 0.0 &gt; Methods for measuring the purity or reversibility of surfactant-containing articles are based on skin barrier breakdown tests. In this test, the smoother the surfactant, the less skin barrier is destroyed. Skin barrier breakdown is measured by the relative amount of radiation-labeled (tritium-labeled) water (3H-H ₂ O) flowing from the test solution through the skin epidermis into the physiological buffer contained in the dialysis chamber. The test is described in TJ Franz, J. Invest. Dermatol. , 1975, 64, pp. 190-195; And U.S. Patent No. 4,673,525 [Small et al., Issued June 16, 1987]. Other test methods known to those skilled in the art for determining the purity of a surfactant can also be used.

A wide variety of foam-forming surfactants are useful in the present invention and are comprised of anionic foam-forming surfactants, nonionic foam-forming surfactants, cationic foam-forming surfactants, amphoteric foam-forming surfactants, &Lt; / RTI &gt;

Anionic foaming surfactant

Non-limiting examples of anionic foaming surfactants useful in compositions of the present invention are described in McCutcheon's, Detergents and Emulsifiers , North American edition (1986), published by Allured Publishing Corporation; McCutcheon ' s, Functional Materials , North American edition (1992); And U.S. Patent No. 3,929,678 [Laughlin et al., Issued December 30, 1975], all of which are incorporated herein by reference in their entirety.

A wide variety of anionic surfactants are useful herein. Non-limiting examples of anionic foaming surfactants include alkyl and alkyl ether sulfates, sulfated monoglycerides, sulfonated olefins, alkylaryl sulfonates, primary or secondary alkanesulfonates, alkyl sulfosuccinates, Acyl isocyanate, alkylsulfoacetate, acylated peptide, alkyl ether, alkyl ether sulfate, alkyl sulfate, acyl sulfate, acyl sulfate, acyl phosphate, Carboxylates, acyl lactates, anionic fluorosurfactants, and combinations thereof. Combinations of anionic surfactants can be used effectively in the present invention.

Anionic surfactants used in the cleansing component include alkyl and alkyl ether sulfates. Wherein the materials each have the formula R ¹ O-SO ₃ M and R ¹ (CH ₂ H ₄ O) _x -O-SO ₃ M wherein R ¹ is a saturated or unsaturated, branched or unbranched carbon number of from about 8 to about X is an integer from 1 to 10 and M is a water soluble cation such as ammonium, sodium, potassium, magnesium, triethanolamine, diethanolamine and monoethanolamine. The alkyl sulfates are typically prepared by sulfation of monohydric alcohols (from about 8 to about 24 carbon atoms) using sulfur trioxide, or other known sulfation techniques. The alkyl ether sulfates are typically prepared by sulfating the condensation products of ethylene oxide and monohydric alcohols (about 8 to about 24 carbon atoms). These alcohols can be derived or synthesized from fats, such as coconut oil or tallow. Specific examples of alkyl sulfates that can be used in the cleansing component include sodium, ammonium, potassium, magnesium or TEA salts of lauryl or myristyl sulfate. Examples of alkyl ether sulfates which may be used include ammonium, sodium, magnesium, or TEA laureth-3 sulfate.

Another suitable class of anionic surfactants are sulfated monoglycerides in the form of R ¹ CO-O-CH ₂ -C (OH) H-CH ₂ -O-SO ₃ M wherein R ¹ is saturated Or an unsaturated, branched or unbranched alkyl group of about 8 to about 24 carbon atoms and M is a water soluble cation such as ammonium, sodium, potassium, magnesium, triethanolamine, diethanolamine, and monoethanolamine. These are typically prepared by the reaction of glycerin with a fatty acid (about 8 to about 24 carbon atoms) to form a monoglyceride followed by sulfating the monoglyceride with sulfur trioxide. An example of a sulfated monoglyceride is sodium coco monoglyceride sulfate.

Other suitable anionic surfactants include olefin sulfonates in the form of R ¹ SO ₃ M wherein R ¹ is a monoolefin having from about 12 to about 24 carbon atoms and M is selected from the group consisting of ammonium, sodium, potassium, magnesium, triethanolamine, di Such as ethanolamine and monoethanolamine. These compounds are prepared by sulfonating alpha olefins using uncomplexed sulfur trioxide and then neutralizing the acid reaction mixture under conditions such that all the sultones formed during the reaction are hydrolyzed to produce the corresponding hydroxyalkanesulfonate . An example of a sulfonated olefin is sodium C14 / C16 alpha olefin sulphonate.

Other suitable anionic surfactants include linear alkylbenzenesulfonates in the form of R ¹ -C ₆ H ₄ -SO ₃ M wherein R ¹ is a saturated or unsaturated, branched or unbranched alkyl group of about 8 to about 24 carbon atoms , And M is a water soluble cation such as ammonium, sodium, potassium, magnesium, triethanolamine, diethanolamine and monoethanolamine. These are formed by sulfonating linear alkylbenzenes with sulfur trioxide. An example of such anionic surfactant is sodium dodecylbenzenesulfonate.

Other anionic surfactants suitable for cleansing ingredients include primary or secondary alkanesulfonates in the form of R ¹ SO ₃ M wherein R ¹ is a saturated or unsaturated, branched or unbranched alkyl chain having from about 8 to about 24 carbon atoms And M is a water soluble cation such as ammonium, sodium, potassium, magnesium, triethanolamine, diethanolamine and monoethanolamine. These are generally produced by sulfonation of paraffins using sulfur dioxide in the presence of chlorine and ultraviolet radiation or by other known sulfonation methods. The sulfonation can occur at the secondary or primary position of the alkyl chain. Examples of alkanesulfonates useful herein include alkali metal or ammonium C13 to C17 paraffin sulfonates.

Other suitable anionic surfactants include alkylsulfosuccinates, which include disodium N-octadecylsulfosuccinamate; Diammonium laurylsulfosuccinate; Tetrasodium N- (1,2-dicarboxyethyl) -N-octadecylsulfosuccinate; Diamyl esters of sodium sulfosuccinic acid; Dihexyl esters of sodium sulfosuccinic acid; And dioctyl esters of sodium sulfosuccinic acid.

Taurine-based taurates, also known as 2-aminoethanesulfonic acid, are also useful. Examples of taurates include N-alkyltaurines such as those prepared by reacting dodecylamine with sodium isethionate, which is described in detail in U.S. Patent No. 2,658,072, which is incorporated herein by reference in its entirety. Other examples based on taurine include acyltaurine produced by reacting n-methyltaurine with a fatty acid (about 8 to about 24 carbon atoms).

Other classes of anionic surfactants suitable for use in cleansing compositions are acyl isethionates. The acyl isethionate typically has the formula R ¹ CO-O-CH ₂ CH ₂ SO ₃ M wherein R ¹ is a saturated or unsaturated, branched or unbranched alkyl group of about 10 to about 30 carbon atoms and M Is a cation. These are generally produced by reacting a fatty acid (about 8 to about 30 carbon atoms) with an alkali metal isethionate. Non-limiting examples of such acyl isethionates include ammonium cocoyl isethionate, sodium cocoyl isethionate, sodium lauroyl isethionate, and mixtures thereof.

Another suitable anionic surfactant is an alkyl glyceryl ether sulfonate in the form of R ¹ -OCH ₂ -C (OH) H-CH ₂ -SO ₃ M wherein R ¹ is a saturated or unsaturated, branched or unbranched, An alkyl group of from about 8 to about 24, and M is a water soluble cation such as ammonium, sodium, potassium, magnesium, triethanolamine, diethanolamine and monoethanolamine. These may be produced by reaction with epichlorohydrin and fatty alcohols of sodium bisulfite (about 8 to about 24 carbon atoms) or other known methods. As an example, there is sodium cocoglyceryl ether sulfonate.

Other suitable anionic surfactants include sulfonated fatty acids in the form of R ¹ -CH (SO ₄ ) -COOH and sulfonated methyl esters in the form of R ¹ -CH (SO ₄ ) -CO-O-CH ₃ , wherein R ¹ is a saturated or unsaturated, branched or unbranched alkyl group of about 8 to about 24 carbon atoms. These may be produced by sulfonation of fatty acids or alkyl methyl esters (about 8 to about 24 carbon atoms) with sulfur trioxide or by other known sulfonation techniques. Examples include alpha-sulfonated coconut fatty acids and lauryl methyl esters.

Other anionic materials include phosphates such as monoalkyl, dialkyl, and trialkyl phosphate salts produced by reaction of phosphorous pentoxide with branched or unbranched, monoalcohols of from about 8 to about 24 carbon atoms. They can also be produced by other known phosphorylation methods. An example of this class of surfactants is sodium mono or dilauryl phosphate.

Other anionic materials include acyl glutamates corresponding to the formula R ¹ CO-N (COOH) -CH ₂ CH ₂ -CO ₂ M, wherein R ¹ is a saturated or unsaturated, branched or unbranched, About 24 alkyl or alkenyl groups, and M is a water soluble cation. Non-limiting examples of these include sodium lauroyl glutamate and sodium cocoyl glutamate.

Other anionic materials include alkanoyl sarcosinates corresponding to the formula R ¹ CON (CH ₃ ) -CH ₂ CH ₂ -CO ₂ M, wherein R ¹ is a saturated or unsaturated, branched or unbranched, 10 to about 20 alkyl and alkenyl groups, and M is a water soluble cation. Non-limiting examples of these are sodium lauroyl sarcosinate, sodium cocoyl sarcosinate, and ammonium lauroyl sarcosinate.

Other anionic materials include alkyl ether carboxylates corresponding to the formula R ¹ - (OCH ₂ CH ₂ ) _x -OCH ₂ -CO ₂ M wherein R ¹ is a saturated or unsaturated, branched or unbranched carbon number An alkyl or alkenyl group of about 8 to about 24, x is 1 to 10, and M is a water soluble cation. Non-limiting examples of these include sodium laureth carboxylate.

Other anionic materials include acyl lactylates corresponding to the formula R ¹ CO- [O-CH (CH ₃ ) -CO] _x -CO ₂ M, wherein R ¹ is a saturated or unsaturated, branched or unbranched An alkyl or alkenyl group having from about 8 to about 24 carbon atoms, x is 3, and M is a water soluble cation. Non-limiting examples of these include sodium cocoyl lactylate.

Other anionic materials include carboxylates, and non-limiting examples thereof include sodium lauroyl carboxylate, sodium cocoyl carboxylate, and ammonium lauroyl carboxylate. Anionic fluorosurfactants may also be used.

Other anionic materials include natural soaps derived from saponification of vegetable and / or animal fats and oils, including, for example, sodium laurate, sodium myristate, palmitate, stearate, tallowate, cocoate .

Any mating cation M can be used in the anionic surfactant. Preferably, the counter cation is selected from the group consisting of sodium, potassium, ammonium, monoethanolamine, diethanolamine, and triethanolamine. More preferably, the counter cation is ammonium.

Nonionic foam forming surfactant

Non-limiting examples of nonionic foam-forming surfactants used in the compositions of the present invention are disclosed in McCutcheon's, Detergents and Emulsifiers , North American edition (1986), published by allured Publishing Corporation; And McCutcheon's Functional Materials , North American Edition (1992), all of which are incorporated herein by reference in their entirety.

Non-ionic, foam-forming surfactants useful herein include those selected from the group consisting of alkyl glucosides, alkyl polyglucosides, polyhydroxy fatty acid amides, alkoxylated fatty acid esters, sucrose esters, amine oxides, and mixtures thereof .

Alkyl glucosides and alkylpolyglucosides are useful herein, and they are broadly referred to as long chain alcohols, e.g., C8-30 alcohol, with sugars or starches, or with sugar or starch polymers, such as condensation with glycosides or polyglycosides Can be defined as products. The compounds may be represented by the formula (S) _n -OR wherein S is a sugar moiety such as glucose, fructose, mannose, and galactose; n is an integer from about 1 to about 1000, and R is a C8-30 alkyl group. Examples of the long chain alcohol from which the alkyl group can be derived include decyl alcohol, cetyl alcohol, stearyl alcohol, lauryl alcohol, myristyl alcohol, oleyl alcohol and the like. Preferred examples of such surfactants include those wherein S is a glucoside moiety, R is an alkyl group of C8-20, and n is an integer from about 1 to about 9. Examples of such commercially available surfactants include decyl polyglucoside (available as APG 325 CS from Henkel) and lauryl polyglucoside (commercially available as APG 600 CS and 625 CS from Henkel). Sucrose ester surfactants such as sucrose cocoate and sucrose laurate are also useful.

Other useful nonionic surfactants include polyhydroxy fatty acid amide surfactants, and more specific examples include glucosamides corresponding to the following chemical formulas:

Wherein R ¹ is H, C ₁ -C ₄ alkyl, 2-hydroxyethyl, 2-hydroxy-propyl, preferably C ₁ -C ₄ alkyl, more preferably methyl or ethyl, Methyl; R ² is C ₅ to C ₃₁ alkyl or alkenyl, preferably C ₇ to C ₁₉ alkyl or alkenyl, more preferably C ₉ to C ₁₇ alkyl or alkenyl, most preferably C ₁₁ to C ₁₅ alkyl Or alkenyl; Z is a polyhydroxyhydrocarbyl moiety having a linear hydrocarbyl chain having at least three hydroxyls directly connected to the chain, or an alkoxylated (preferably ethoxylated or propoxylated) derivative thereof. Z is preferably a sugar moiety selected from the group consisting of glucose, fructose, maltose, lactose, galactose, mannose, xylose and mixtures thereof. Particularly preferred surfactants corresponding to this structure are coconut alkyl N-methyl glucoside amides (i.e. the R ² CO- moiety in the formula is derived from coconut oil fatty acid). Methods for making compositions containing polyhydroxy fatty acid amides are described, for example, in British Patent Specification No. 809,060 (published February 18, 1959, Thomas Hedley & Co., Ltd.); U.S. Patent No. 2,965,576 [ER Wilson, issued December 20, 1960]; U.S. Patent No. 2,703,798 [AM Schwartz, issued March 8, 1955]; And U.S. Patent No. 1,985,424 [Piggott, issued December 25, 1934]; Each of which is incorporated herein by reference in its entirety.

Other examples of nonionic surfactants include amine oxides. Amine oxides correspond to the general formula R ₁ R ₂ R ₃ N → O, wherein R ₁ is an alkylene group having from about 8 to about 18 carbon atoms, from 0 to about 10 ethylene oxide moieties, and from 0 to about 1 glyceryl moiety R ₂ and R ₃ are independently selected from the group consisting of carbon atoms of from about 1 to about 3, and hydroxy groups of from 0 to about 1, such as methyl, ethyl, propyl, hydroxyethyl, Or hydroxypropyl radicals. The arrows in the above formula are typical signs of semi polar bonding. Examples of amine oxides suitable for use in the present invention include dimethyl-dodecylamine oxide, oleyldi (2-hydroxyethyl) amine oxide, dimethyloctylamine oxide, dimethyl-decylamine oxide, dimethyl-tetradecylamine oxide, 3 , 6,9-trioxoheptadecyldimethylamine oxide, di (2-hydroxyethyl) -tetradecylamine oxide, 2-dodecoxyethyldimethylamine oxide, 3-dodecoxy-2-hydroxypropyl di (3-hydroxypropyl) amine oxide, and dimethylhexadecylamine oxide.

Non-limiting examples of preferred non-ionic surfactants for use herein include, but are not limited to, C8 to C14 glucosamide, C8 to C14 alkyl polyglucoside, sucrose cocoate, sucrose laurate, lauramine oxide, cocoamine oxide , And mixtures thereof.

Cationic foam-forming surfactant

Cationic foam-forming surfactants are also useful in the articles of the present invention. Suitable cationic foaming surfactants include, but are not limited to, fatty amines, di-fatty quaternary amines, tri-fatty quaternary amines, imidazolinium quaternary amines, and combinations thereof. Suitable fatty amines include monoalkyl quaternary amines such as cetyltrimethylammonium bromide. A suitable quaternary amine is dialkylamidoethylhydroxyethylmonium methosulfate. However, fatty amines are preferred. If the cationic foam-forming surfactant is the major foam-forming surfactant of the cleansing component, it is preferred that a foam-forming promoter is used. It has also been found that nonionic surfactants are particularly useful when used with such cationic foam forming surfactants.

Amphoteric foam forming surfactant

As used herein, the term " amphoteric foam forming surfactant " is intended to encompass well known zwitterionic surfactants, well known to the skilled artisan, as subset of amphoteric surfactants Respectively.

A wide variety of amphoteric foam forming surfactants may be used in the compositions of the present invention. In particular, those broadly mentioned as derivatives of aliphatic secondary and tertiary amines are particularly useful, preferably wherein the nitrogen is cationic, the aliphatic radicals are linear or branched, and one of the radicals is ionized Soluble water-soluble groups, such as carboxy, sulfonate, sulfate, phosphate, or phosphonate.

Non-limiting examples of amphoteric surfactants useful in compositions of the present invention include McCutcheon's, Detergents and Emulsifiers , North American edition (1986) (allured Publishing Corporation); And McCutcheon's, Functional Materials , North American Edition (1992), all of which are incorporated herein by reference in their entirety.

Non-limiting examples of amphoteric or zwitterionic surfactants are selected from the group consisting of betaines, sultaines, hydroxysultaines, alkyliminoacetates, iminodialcanoates, aminoalkanoates, and mixtures thereof They are.

Examples of betaine are cocodimethylcarboxymethylbetaine, lauryldimethylcarboxymethylbetaine, lauryldimethylcarboxyethylbetaine, cetyldimethylcarboxymethylbetaine, cetyldimethylbetaine (available as Lonzaine 16SP from Lonza Corp.) ), Laurylbis- (2-hydroxyethyl) carboxymethylbetaine, oleyldimethylgamma-carboxypropylbetaine, laurylbis- (2-hydroxypropyl) alpha-carboxyethylbetaine, cocodimethylsulfopropyl (2-hydroxyethyl) sulfopropyl betaine, amidobetaine, and amidosulfobetaine, wherein the RCONH (CH ₂ ) ₃ radical is selected from the group consisting of nitrogen of betaine (Commercially available from Henkel as Velvetex OLB-50), and cocamidopropyl betaine (available from Henkel as Velvetex BK-35 and BA-35) Includes others.

Examples of sultaine and hydroxysultaine include materials such as cocamidopropylhydroxysultaine (available as Mirataine CBS from Rhone-Poulenc).

It is preferred that amphoteric surfactants having the following structure be used:

In the formula, R ¹ is an unsubstituted, saturated or unsaturated, straight or branched chain alkyl of about 9 to about 22 carbon atoms. R ¹ preferably has about 11 to about 18 carbon atoms, more preferably about 12 to about 18 carbon atoms; Even more preferably from about 14 to about 18 carbon atoms; m is an integer from 1 to about 3, more preferably from about 2 to about 3, and even more preferably about 3; n is 0 or 1, preferably 1; R ² and R ³ are independently selected from the group consisting of alkyl having 1 to about 3 carbon atoms, unsubstituted or mono-substituted with hydroxy group, R ² and R ³ are preferably CH ₃ ; X is selected from the group consisting of CO ₂ , SO ₃ and SO ₄ ; R ⁴ is selected from the group consisting of alkyl having 1 to about 5 carbon atoms, saturated or unsaturated, linear or branched, unsubstituted or monosubstituted with hydroxy groups. When X is CO ₂ , R ⁴ is preferably 1 or 3 carbon atoms, more preferably 1. When X is SO ₃ or SO ₄ , R ⁴ preferably has about 2 to about 4 carbon atoms, and more preferably 3 carbon atoms.

Examples of amphoteric surfactants of the present invention include the following compounds:

Cetyldimethylbetaine (the name of CTFA is cetyl betaine)

Cocamidopropyl betaine

(Wherein the number of carbon atoms of R is about 9 to about 13)

Cocamidopropylhydroxysulfate

(Wherein the carbon number of R is about 9 to about 13).

Examples of other useful amphoteric surfactants are alkyliminoacetates and iminodialkanoates of the formula RN [(CH ₂ ) _m CO ₂ M] ₂ and RNH (CH ₂ ) _m CO ₂ M and aminoalkanoates and a, and where m is 1 to 4, R is a C ₈ ~ C ₂₂ alkenyl or alkyl Al, m is H, alkali metal, alkaline earth metal, ammonium or alkanol ammonium. Also included are imidazolidinium and ammonium derivatives. Specific examples of suitable amphoteric surfactants include sodium 3-dodecyl-aminopropionate, sodium 3-dodecylaminopropanesulfate, sodium 3-dodecylaminopropionate, and the like, as prepared in accordance with the teachings of U.S. Patent No. 2,438,091, incorporated herein by reference in its entirety. Nate, N-higher alkyl aspartic acid; And the products described in U.S. Patent No. 2,528,378, which is marketed under the trade name " Miranol &quot;, incorporated herein by reference in its entirety. Examples of other amphoteric materials that are useful include amphiphilic phosphates such as coramidopropyl PG-dimonium chloride phosphate (available as Monaquat PTC from Mona Corp.). Amphoacetates such as disodium lauroamphodiacetate, sodium lauroamphoacetate, and mixtures thereof are also useful.

Preferred foam-forming surfactants are ammonium lauroyl sarcosinate, sodium trideceth sulfate, sodium lauroyl sarcosinate, ammonium laureth sulfate, sodium laureth sulfate, ammonium lauryl sulfate, sodium lauryl sulfate, Ammonium cocoyl isethionate, sodium cocoyl isethionate, sodium lauroyl isethionate, sodium cetyl sulfate, sodium monolauryl phosphate, sodium coco glyceryl ether sulphonate, sodium C ₉ -C ₂₂ Anionic foaming surfactants selected from the group consisting of soaps, and combinations thereof; Selected from the group consisting of laurylamine oxide, cocoamine oxide, decylpolyglucose, lauryl polyglucose, sucrose cocoate, C12-14 glucosamides, sucrose laurate, and combinations thereof. Surfactants; A cationic foam-forming surfactant selected from the group consisting of fatty amines, di-fatty quaternary amines, tri-fatty quaternary amines, imidazolinium quaternary amines, and combinations thereof; An amphoteric foam-forming surfactant selected from the group consisting of disodium lauroamphodiacetate, sodium lauroamphoacetate, cetyldimethylbetaine, cocoamidopropyl betaine, cocoamidopropylhydroxysultaine, and combinations thereof &Lt; / RTI &gt;

Cationic surfactant

Cationic surfactants are typically categorized as non-foam forming surfactants, but they can be used in the articles of the present invention provided they do not adversely affect the desired benefits of the articles of the present invention.

Non-limiting examples of cationic surfactants useful herein include McCutcheon ' s Detergents and Emulsifiers , North American edition (1986), published by allured Publishing Corporation; And McCutcheon's, Functional Materials , North American Edition (1992); All of which are incorporated herein by reference in their entirety.

Non-limiting examples of cationic surfactants useful herein include cationic alkylammonium salts such as those having the following formula:

R ₁ R ₂ R ₃ R ₄ N ⁺ X ^-

Wherein R ₁ is selected from an alkyl group having from about 12 to about 18 carbon atoms or an aromatic, aryl or alkaryl group having from about 12 to about 18 carbon atoms; R ₂ , R ₃ , and R ₄ are independently selected from hydrogen, an alkyl group having from about 1 to about 18 carbon atoms, or an aromatic, aryl, or alkaryl group having from about 12 to about 18 carbon atoms; X is an anion selected from chloride, bromide, iodide, acetate, phosphate, nitrate, sulfate, methylsulfate, ethylsulfate, tosylate, lactate, citrate, glycolate, and mixtures thereof. Additionally, the alkyl group may also contain ether bonds, or hydroxy or amino group substituents (e.g., the alkyl group may contain polyethylene glycol and polypropylene glycol moieties).

More preferably, R ₁ is an alkyl group having from about 12 to about 18 carbon atoms; R ₂ is selected from hydrogen or an alkyl group having from about 1 to about 18 carbon atoms; R ₃ and R ₄ are independently selected from hydrogen or an alkyl group having from about 1 to about 3 carbon atoms; X is as described in the preceding paragraph.

Most preferably, R &lt; ₁ &gt; is an alkyl group having from about 12 to about 18 carbon atoms; R ₂ , R ₃ , and R ₄ are selected from hydrogen or an alkyl group having from about 1 to about 3 carbon atoms; X is as described above.

Alternatively, another useful cationic surfactant includes an amino acid-amide wherein R ₁ is optionally R ₅ CO- (CH ₂ ) _n -, wherein R ₅ is an alkyl group having from about 12 to about 22 carbon atoms And n is an integer from about 2 to about 6, more preferably from about 2 to about 4, and most preferably from about 2 to about 3. Nonlimiting examples of such cationic emulsifiers are stearamidopropyl PG-dimonium chloride phosphate, stearamidopropyl ethyl dimonium ethosulfate, stearamidopropyl dimethyl (myristyl acetate) ammonium chloride, stearamidopropyl dimethyl Cetearyl ammonium tosylate, stearamidopropyl dimethyl ammonium chloride, stearamidopropyl dimethyl ammonium lactate, and mixtures thereof.

Non-limiting examples of quaternary ammonium salt cationic surfactants include cetyl ammonium chloride, cetyl ammonium bromide, lauryl ammonium chloride, lauryl ammonium bromide, stearyl ammonium chloride, stearyl ammonium bromide, cetyl dimethyl ammonium chloride, cetyl dimethyl ammonium Examples of the organic solvent include bromine, lauryldimethylammonium chloride, lauryldimethylammonium bromide, stearyldimethylammonium chloride, stearyldimethylammonium bromide, cetyltrimethylammonium chloride, cetyltrimethylammonium bromide, lauryltrimethylammonium chloride, lauryltrimethylammonium bromide, Trimethylammonium chloride, stearyltrimethylammonium bromide, lauryldimethylammonium chloride, stearyldimethylcetyldialdimethylammonium chloride Dicetylammonium chloride, dicetylammonium bromide, dicetylammonium bromide, distearylammonium bromide, distearylammonium chloride, distearylammonium bromide, dicetylmethylammonium chloride, dicetylmethylammonium bromide, dilaurylmethylammonium bromide, But are not limited to, those selected from the group consisting of chloride, dilaurylmethylammonium bromide, distearylmethylammonium chloride, distearyldimethylammonium chloride, distearylmethylammonium bromide, and mixtures thereof. Additional quaternary ammonium salts include those wherein the C12 to C22 alkyl carbon chain is derived from tallow fatty acid or coconut fatty acid. The term " tallow " refers generally to an alkyl group derived from a tallow fatty acid (generally hydrogenated tallow fatty acid) having a mixture of alkyl chains in the C16 to C18 range. The term " coconut " refers to an alkyl group derived from coconut fatty acid having a mixture of alkyl chains generally in the range of C12 to C14. Examples of quaternary ammonium salts derived from such trough and coconut sources include ditallow dimethyl ammonium chloride, ditallow dimethyl ammonium methyl sulfate, di (hydrogenated tallow) dimethyl ammonium chloride, di (hydrogenated tallow) dimethyl (Coconut alkyl) dimethyl ammonium bromide, tallowammonium chloride, coconut ammonium chloride, stearamidopropyl PG-1 (coconut alkyl) dimethyl ammonium chloride, dibutyl ammonium chloride, Stearamidopropyldimonium ethosulfate, stearamidopropyldimethyl (myristyl acetate) ammonium chloride, stearamidopropyl dimethyl cetearyl ammonium tosylate, stearamidopropyl dimethyl ammonium chloride Lauride, stearamidopropyl dimethyl ammonium lactate, and mixtures thereof.

Preferred cationic surfactants useful herein are selected from the group consisting of dilauryldimethylammonium chloride, distearyldimethylammonium chloride, dimyristyldimethylammonium chloride, dipalmityldimethylammonium chloride, distearyldimethylammonium chloride, and mixtures thereof. Includes selected ones.

Chelators

The articles of the invention may also contain a safe effective amount of a chelator or chelating agent. As used herein, " chelator " or " chelating agent " means an active agent capable of removing metal ions from the system by forming a complex so that the metal ion is not readily precipitated or can not catalyze a chemical reaction. The incorporation of chelating agents is particularly useful in providing protection against UV radiation that can contribute to excessive scaling or skin texture changes and other environmental factors that can cause skin damage.

A safe effective amount of a chelating agent may be added to the compositions of the present invention, preferably from about 0.1% to about 10%, more preferably from about 1% to about 5% of the composition. An exemplary chelator useful herein is U.S. Patent No. 5,487,884 [Bissett et al., Issued January 30, 1996]; International Publication No. 91/16035 [Bush et al., Published October 31, 1995]; And International Publication No. 91/16034 [Bush et al., Published October 31, 1995]. Preferred chelators useful in the compositions of the present invention are fuoridoxime and derivatives thereof.

Flavonoid

The article of the present invention may optionally comprise a flavonoid compound. Flavonoids are described extensively in U.S. Patent Nos. 5,686,082 and 5,686,367, which are incorporated herein by reference. Flavonoids suitable for use in the present invention include flavanones selected from the group consisting of unsubstituted flavanones, mono-substituted flavanones, and mixtures thereof; A chalcone selected from the group consisting of unsubstituted chalcone, mono-substituted chalcone, di-substituted chalcone, tri-substituted chalcone, and mixtures thereof; A flavone selected from the group consisting of unsubstituted flavone, mono-substituted flavone, di-substituted flavone, and mixtures thereof; One or more isoflavones; Coumarin selected from the group consisting of unsubstituted coumarin, mono-substituted coumarin, di-substituted coumarin, and mixtures thereof; A chromone selected from the group consisting of unsubstituted chromone, mono-substituted chromone, di-substituted chromone, and mixtures thereof; At least one decumarole; At least one chromanone; At least one chromanol; Isomers thereof (e.g., cis / trans isomers); And mixtures thereof. The term " substituted " as used herein means a flavonoid in which one or more hydrogen atoms of the flavonoid are independently replaced by hydroxyl, C1-C8 alkyl, C1-C4 alkoxy, O-glycoside, or the like, or a mixture of such substituents.

Examples of suitable flavonoids include, but are not limited to, unsubstituted flavanone, mono-hydroxy flavanone (e.g., 2'-hydroxy flavanone, 6-hydroxy flavanone, 7-hydroxy flavanone, etc.) ), Mono-alkoxyflavanones (e.g., 5-methoxy flavanone, 6-methoxy flavanone, 7-methoxy flavanone, 4'-methoxy flavanone, Dihydroxychalcone (for example, 2 ', 4-dihydroxychalcone), mono-hydroxycalcone (for example, 2'- Dihydroxycalcone, 2'4'-dihydroxycalcone, 2,2'-dihydroxychalcone, 2 ', 3-dihydroxychalcone, 2', 5'- dihydroxychalcone, etc.), and trihydroxy (2 ', 3', 4'-trihydroxychalcone, 4,2 ', 4'-trihydroxychalcone, 2,2', 4'-trihydroxychalcone, etc.) Dihydroxyflavone, 3'4'-dihydroxynaphtho toflavone, 4'-hydroxyphosphate, 4'- 5,6-benzoflavone, 7,8-benzoflavone, unsubstituted isoflavone, deadzine (7,4'-dihydroxyisoflavone), 5,7-dihydroxy-4'- Hydroxy-4-methylcoumarin, unsubstituted chromone, 3-hydroxy-4-methylcoumarin, and mixtures thereof. Formylchromone, 3-formyl-6-isopropylchromone, unsubstituted dicumarol, unsubstituted chromanone, unsubstituted chromanol, and mixtures thereof.

It is preferred that the unsubstituted flavanone, methoxy flavanone, unsubstituted chalcone, 2 ', 4-dihydroxychalcone, and mixtures thereof are used herein. Unsubstituted flavanones, unsubstituted chalcones (especially trans isomers), and mixtures thereof are most preferred.

These may be synthetic or obtained as extracts from natural sources (e.g., plants). Substances from natural sources may be further derivatized (e. G., Glycosides, esters or ether derivatives prepared from natural sources). The useful flavonoid compounds herein are commercially available from a number of suppliers including, for example, Indofine Chemical Company, Inc. (Somerville, New Jersey), Steraloids, Inc. (Wilton, New Hampshire), and Aldrich Chemical Company, , Wisconsin).

Mixtures of the above flavonoid compounds may also be used.

The flavonoid compounds described herein are preferably present in the present invention at a concentration of from about 0.01% to about 20%, more preferably from about 0.1% to about 10%, and most preferably from about 0.5% to about 5%.

Sterol

The articles of the invention may contain one or more sterol compounds in a safe effective amount. Examples of useful sterol compounds include sitosterol, stigmasterol, campesterol, brassicasterol, lanosterol, 7-dihydrocholesterol, and mixtures thereof. They may be of a synthetic or natural source, for example a mixture extracted from plant sources (for example, phytosterol).

Anticellulite

The articles of the invention may also contain a safe effective amount of an anti-cellulite agent. Suitable materials include, but are not limited to, xanthine compounds (e.g., caffeine, theophylline, theobromine, and aminophylline).

Skin whitening agent

The articles of the present invention may comprise a skin lightening agent. When used, the compositions preferably comprise from about 0.1% to about 10%, more preferably from about 0.2% to about 5%, and more preferably from about 0.5% to about 2%, of a skin lightening agent, do. Suitable skin lightening agents include those known in the art, including kojic acid, arbutin, ascorbic acid and derivatives thereof, such as magnesium ascorbyl phosphate or other salts of sodium ascorbyl phosphate or ascorbyl phosphate. Suitable skin lightening agents for use herein are also described in co-pending patent application Serial No. 08 / 479,935 (filed June 7, 1995 under the name of Hillebrand), corresponding PCT Application No. 95/07432 (filed June 12, 1995) ; And co-pending patent application Ser. No. 08 / 390,152 filed February 24, 1995 under the names of Kalla L. Kvalnes, Mitchell A. DeLong, Barton J. Bradbury, Curtis B. Motley, and John D. Carter, PCT Application US 95/02809 (filed March 1, 1995, published September 8, 1995).

Binder

The article of the present invention may optionally comprise a binder. Binders or binding materials are useful for maintaining the integrity of an article by sealing multiple layers of the article of the present invention together. The binder may be in various forms including, but not limited to, spray, web, separating layer, bonded fibers, and the like. Suitable binders may include latexes, polyamides, polyesters, polyolefins, and combinations thereof.

Additional layers

In a preferred embodiment, the article of the present invention is recognized by those skilled in the art as distinct and separate from the creped nonwoven layer, but may in some respects include one or more additional layers attached to the creped nonwoven layer . The additional layers are suitable for improving the overall grippability of the portion closest to the hand of the article or other means for exhibiting mechanical action on the surface to be cleansed and / or therapeutically treated. In addition, the additional layers are suitable for improving the soft touch of the part of the article that is in contact with the area to be treated for cleansing and / or treatment. In any case, these additional layers may be referred to as a continuous numbered layer, such as a third layer, a fourth layer, etc., in addition to the two layers essential to the article of the present invention.

Suitable additional layers can be macroscopically expanded. The expression " macroscopically expanded ", as used herein, is intended to encompass a web, a ribbon, a web, or the like, which is adapted to the surface of a three-dimensional shaping structure so that both surfaces thereof all exhibit a three- dimensional shaping pattern of the surface deformation corresponding to the macroscopic cross- And film wherein the surface deformations containing the pattern are at a normal distance of approximately 12 inches from the viewer's eye and the web surface, It is possible to distinguish it as a).

As used herein, the expression " embossed " means that the forming structure of the material represents a pattern consisting mainly of protruding protrusions. On the other hand, the expression " debossed " refers to a case in which the molding structure of a material represents a pattern consisting mainly of depressed capillary networks.

A preferred macroscopically expanded film comprises a shaped film which is a structural carbon film. Such films are described in U.S. Patent No. 5,554,145 [Roe et al., Issued September 10, 1996], which is hereby incorporated by reference in its entirety.

Materials suitable for use in additional layers having a thickness of greater than or equal to 1 millimeter include, but are not limited to, web materials disclosed in U.S. Patent No. 5,518,801 (Chappell et al., Issued May 21, 1996), which is incorporated herein by reference in its entirety .

Manufacturing method

The personal care articles of the present invention may be applied to any existing personal care article that may include, but is not limited to, sprinkling, dip coating, spraying, slot coating, and roll transfer By adding a cleansing component and a therapeutic efficacy member (if applicable) to a suitable sheet of the first layer which is a nonwoven fabric. The sheet of the remaining layer is then placed on the cleansing component and the therapeutic efficacy member (if applicable), but not always, preferably on the first layer sheet. The sheets are sutured together by conventional suturing methods which may include, but are not limited to, heat, pressure, pull, ultrasound, and the like. The heated stitchers can be of various designs and, when not possible to seal, insert a low melting hot-melt synthetic fibrous web, such as a polyamide fibrous web known as Wonder Under (manufactured by Pellon, H.Levinson & Co., Chicago, IL) Layer can be used between the layers for these and other examples without changing the effectiveness or utility of the article. Thereafter, the sealed sheets are distributed in units for consumer use. Any manufacturing steps may include calendaring to flatten the article and drying, creping, shrinking, stretching or other mechanical deformation steps.

Cleansing and treatment of skin or hair or delivery of cosmetic ingredients

The present invention relates to a method of cleansing skin or hair with a personal care article of the present invention. These methods comprise the following steps: a) a water-insoluble substrate containing a nonwoven; And a substantially dry disposable personal care article comprising a therapeutically efficacious member disposed adjacent the water insoluble substrate wherein the component comprises a safe effective amount of anionic &lt; RTI ID = 0.0 &gt; A polymer and a safe effective amount of a cationic surfactant, wherein the composition forms a coacervate when the article is exposed to water, with water; And b) contacting the wetted article with skin or hair.

The article of the present invention is water-activated and therefore must be wetted with water before use. The expression " water-activated ", as used herein, means that the present invention is provided to the consumer in a dry form to be used after being wetted with water. When the articles of the present invention comprise a foam-forming surfactant, they have found that they include " being activated " by bubbling, or by contact with and further stirring with water. Thus, the article is wetted by immersion in water or by placing it under water flow. When the article of the present invention contains a foam-forming surfactant in the cleansing component, foam may be produced from the article by mechanically agitating and / or deforming the article before or during contact with the skin or hair. The resulting foam is useful for cleansing the skin or hair. During the cleansing process and during continuous rinsing with water, any therapeutic or cosmetic efficacy member is deposited on the skin or hair. The deposition of the absence of therapeutic or cosmetic efficacy is improved not only by the physical contact of the skin or hair with the substrate, but also by the incorporation of one or more deposition aids.

The following examples further illustrate and demonstrate implementations falling within the scope of the present invention. In the following examples, all components are listed as active levels. The embodiments are for illustrative purposes only and should not be construed as limiting the invention since various changes may be made thereto without departing from the spirit and scope of the invention.

The constituents are identified by chemical name or CTFA name.

Ⅰ. Cleansing ingredient

Example 1

Representative cleansing ingredients for the articles of the present invention are prepared in the following manner.

Shears 53.0 gms of soap bar containing the following ingredients:

ingredient weight% Sodium cochleate isethionate 27.77 paraffin 16.72 Sodium alkyl glycerol sulfonate (AGS) 14.90 soap 11.41 glycerin 8.57 water 5.50 Stearic acid 5.74 Sodium isethionate 3.04 NaCl 1.41 EDTA 0.10 Etidronate 0.10 Polyox 0.03 Spices 0.70 Other (with pigment) 4.01 synthesis 100

The soap bar debris is mixed with 37.0 gms of glycerin (99.7%), 9.5 gms of water and 0.5 gms of perfume. The mixture is heated to &lt; RTI ID = 0.0 &gt; 200 F &lt; / RTI & The mixture is cold-milled in a standard three-roll mill and the cleansing ingredients are stored in a suitable sealed container.

Example 2

Representative cleansing ingredients for the articles of the present invention are prepared in the following manner.

40.0 gms of a soap bar containing the following ingredients are excised:

ingredient weight% Sodium soap 52.40 Sodium alkyl glycerol sulfonate (AGS) 16.50 Magnesium soap 13.40 glycerin 0.19 water 5.50 Stearic acid 1.60 Sodium isethionate 3.00 NaCl 3.89 EDTA 0.10 Etidronate 0.10 Spices 0.70 Other (with pigment) 2.62 synthesis 100

The soap bar flakes are mixed with 45.0 gms of glycerin (99.7%), 4.5 gms of water and 0.5 gms of perfume. The mixture is heated to &lt; RTI ID = 0.0 &gt; 200 F &lt; / RTI & The mixture is cold-milled in a standard three-roll mill and the cleansing ingredients are stored in a suitable sealed container.

Example 3

Representative powder cleansing ingredients for the articles of the invention are prepared by the following method.

Slice 40.0 gms of soap bar containing the following ingredients:

ingredient weight% Soap (magnesium and sodium) 80.16 water 11.50 Stearic acid 5.70 NaCl 1.10 EDTA 0.25 Spices 1.15 Other (with pigment) 0.14 synthesis 100

Store the soap bar flakes in a suitable sealed container.

Example 4

Representative powder cleansing ingredients for the articles of the invention are prepared by the following method.

40.0 gms of a soap bar containing the following ingredients are excised:

ingredient weight% Soap (magnesium and sodium) 80.16 water 11.50 Stearic acid 5.70 NaCl 1.10 EDTA 0.25 Spices 1.15 Other (with pigment) 0.14 synthesis 100

The soap bar flakes are combined with sodium bicarbonate in a weight ratio of 90:10. The mixture is pulverized twice in a standard 3-roll mill. Collect flakes and store in appropriate sealed containers.

Example 5

Representative cleansing ingredients for the articles of the present invention are prepared in the following manner. The cleansing component of Example 2 is combined with 0.1% by weight of the protease enzyme relative to the soap bar flake weight. The resulting mixture is then blended with sodium carboxymethylcellulose, which is a dry hydrocolloid of 2% by weight, based on the weight of the cleansing ingredients, and milled. Store the enzyme cleansing ingredients in a suitable sealed container.

Example 6

A representative liquid cleansing component comprising the following ingredients is prepared.

ingredient weight% Sodium coconut alkyl glyceryl sulphonate (AGS) 7.2 Ammonium lauryl sulfate (ALS) 10.4 Alkyl laureth sulfate (AE3S) 10.4 Poly (ethylene oxide) (Polyox WSR N-3000, Union Carbide) 0.5 Xanthan gum 1.4 water 70.1

Example 7

Representative cleansing ingredients for the articles of the present invention are prepared in the following manner. Heat 3 lbs of the soap scum of Example 2 with 3/4 cup isopropyl alcohol (99%) until the soap melts. When the soap has melted, the residual alcohol is added. As little as possible, 10 oz. Add table sugar. Dye about 4 tsp. Glycerin 8 oz. . Glycerin (99.7%) is added. Lt; / RTI &gt; The viscosity changes from a dilute liquid to a rope-like ribbon when the agitator is released, and heating is continued until the aliquot of material is cured when dropped onto a cold surface. The mixture is poured into an appropriate container and cured. The mixture has the advantage of being remelted by heating, facilitating the process for producing the article.

Example 8

A typical tear-free liquid cleansing composition comprising the following ingredients is prepared.

ingredient weight% Cocamidopropyl betaine 17.1 Sodium trideceth sulfate 8.3 POE 100 sorbitan monooleate 7.5 Others (including fragrances, preservatives, dyes) 2.0 water 65.1

A distinctive feature of the composition is its non-irritating properties to the skin and eyes.

Example 9

A representative liquid cleansing component comprising the following ingredients is prepared.

ingredient weight% Polyquaternium 10 0.50 Sodium lauroamphoacetate 5.4 Sodium laureate 3 sulfate 11.6 Disodium EDTA 0.20 Sodium citrate dihydrate 0.50 Citric acid, anhydrous 1.0 PEG-6 caprylic / capric acid glyceride 2.0 Cocamide MEA 2.0 glycerin 3.5 MgSO ₄ -7H ₂ O (epsom salt) 1.5 Maleate soya bean oil 2.5 Deodorant soybean oil 5.0 Others (including fragrances, caustics, and colorants) 1.5 water 62.8

The mixture can be used for sensitive skin.

Example 10

A representative liquid cleansing component comprising the following ingredients is prepared.

ingredient weight% Polyquaternium-10 0.1 Sodium sulfate 1.5 Lauryl alcohol 0.3 Sodium laureth sulfate 5.8 Citric acid, anhydrous 0.2 Cocamidopropyl betaine 15.5 Sodium lauroyl sarcosinate 1.5 Others (including fragrance, blue colorant) 1.0 water 74.1

Example 11

A representative cleansing component comprising the following ingredients is prepared.

ingredient weight% Decyl polyglucose 12.0 Cocamidopropyl betaine 12.0 Sodium lauroyl sarcosinate 12.0 Butylene glycol 3.6 PEG 14M 1.8 Polyquaternium-10 0.9 Dexpanthenol 0.7 Phenoxyethanol 0.5 Benzyl alcohol 0.5 Methyl paraben 0.45 Propylparaben 0.25 Disodium EDTA 0.2 water 55.1

Example 12

A representative cleansing component comprising the following ingredients is prepared.

ingredient weight% EGDS 3.1 Cocamidopropyl betaine 4.0 TEA soap (molecular weight about 330) 9.5 Monoalkyl phosphate 15.0 Cocamine oxide 7.5 1,2-propanediol 1.0 ethanol 3.0 Others (fragrances, colorants, preservatives) 8.9 water 48.0

The mixture is heated to 50 DEG C with continued stirring until the mixture has lost its original weight of 38% and has a paste-like viscosity. The cleansing component is advantageous because it is easy to process with the substrate layer and does not require further drying.

Example 13

A representative cleansing component comprising the following ingredients is prepared.

ingredient weight% SEFA ^* Cotonate 57.5 Citric acid 0.30 Cocamidopropyl betaine 3.5 Sodium lauroyl sarcosinate 10.7 Ethylene vinyl acetate polymer (Elvax 40W) 8.0 Silicone polymer microbeads (Tospearly 145A) 20.0

^* SEFA is an acronym for sucrose esters of fatty acids.

The ethylene vinyl acetate polymer is melted at 90 DEG C with SEFA cotonate and high shear mixed. Add surfactant powder and citric acid and mix. Silicone polymer microbeads are added, mixed and allowed to cool. The composition is re-meltable and is easily impregnated or coated on the fabric.

Example 14

A representative cleansing component comprising the following ingredients is prepared.

ingredient weight% Sodium laureth-10 carboxylate (MPCol CB5S ^* ) 50.0 C12-14, 12EO Alcohol ethoxylate (Empran KB12 ^* ) 50.0

^* Available from Albright & Wilson.

The alcohol ethoxylate is melted, blended into the carboxylate until homogeneous, and cooled and solidified until ready for use. The composition is re-meltable and is easily impregnated or coated on the fabric.

Example 15

A representative cleansing component comprising the following ingredients is prepared.

ingredient weight% Monosodium lauroyl glutamate 22.0 Cocamidopropyl betaine 2.0 Sodium chloride 1.0 glycerin 2.5 water 72.5

The components are heated together with gentle stirring until homogeneous.

Example 16

A representative cleansing component comprising the following ingredients is prepared.

ingredient weight% Triethanolamine 2.9 Polyquaternium-39 0.1 Monolauryl phosphate 4.0 C ₁₂ -C ₁₄ N-methyl glucoside amide ¹ 5.0 Cocamidopropylhydroxysulfathane ² 2.0 Sodium decyl sulfate 0.5 Citric acid monohydrate 0.3 Spices, preservatives & others. 4.0 water 81.2

Available from ¹ Hoechst Celanese

² Available from Rhone Poulenc

Add the components slowly at 60 ° C in the following order, until each component dissolves in water: TEA, lauryl phosphate, glucosamide. Cool to 45 &lt; 0 &gt; C and add sultaine, polyquaternium-39 and sulfate while stirring as described above. Add flavorings and preservatives, and cool to room temperature.

Example 17

A typical cleansing component is prepared by mixing the following ingredients.

ingredient weight% Lauroyl polyglucose ¹ 20.0 Cetyltrimethylammonium bromide 4.0 Spices, Preservatives & Others 4.0 water 72.0

¹ Available as Plantaren 1200 from Henkel

Ⅱ. Absence of therapeutic efficacy

Examples 18-22

Representative skin conditioning ingredients are prepared by mixing the following ingredients.

ingredient Example 18 Example 19 Example 20 Example 21 Example 22 SEFA ^* Cotonate 48.0 75.0 33.5 40.0 80.0 SEFA ^* Behenate 12.0 25.0 8.4 10.0 10.0 Petro LeThem 10.0 - 7.0 - - Glyceryl tribehenate 5.0 - 3.5 - - Stearyl alcohol - - - 5.0 - paraffin - - - 15.0 - Cholesterol ester 25.0 - 17.5 - - Ozokerite wax - - - - 10.0 glycerin - - 28.0 - - Triglyceryl monostearate - - 1.9 - - Decaglyceryl dipalmitate - - 0.2 - - Nonylphenol polyglycine ether ¹ - - - 30.0 -

^* SEFA is an acronym for sucrose esters of fatty acids.

¹ Hamplex TNP, Hampshire Chemical Co.

Examples 23-27

The following ingredients are mixed to produce representative skin conditioning ingredients.

ingredient Example 23 Example 24 Example 25 Example 26 Example 27 Petroretum (white) 35.87 35.87 - - 34.0 Mineral oil 11.0 13.0 - - 10.0 Jojoba oil - - - 4.5 Castor oil 10.0 9.0 - - Cocoa butter 5.0 Diisostearyl trimethylpropane siloxysilicate 20.0 20.0 - - Polydimethylsiloxane, 500 cSt latex - - 0.7 1.5 Decamethylcyclopentasiloxane - - - 16.5 Octamethylcyclotetrasiloxane - - - 10.0 Polydimethylsiloxane, sword - - 5.9 7.5 Stearyl methicone wax - - - 3.0 Polybutene - - - 4.5 Candelilla wax 4.6 4.6 - - 6.0 Paraffin wax - - - 15.0 2.0 Microcrystalline wax - - - 6.0 4.0 Wax 3.0 3.0 - - 4.0 Ozokerite wax 6.0 6.0 - - Carnauba wax 3.0 3.0 - - Hydrogenated castor oil 0.50 0.50 4.0 - Silica - - - 4.5 Sodium magnesium silicate - - - 1.5 Tocopherol 0.03 0.03 - - Cyclomethicone - - 59.0 - Stearyl alcohol - - 25.5 - 9.0 Cetyl alcohol 9.0 Glyceryl stearate - - 2.6 - Acetylated monoglyceride 15.0 Diisostearyl maleate ¹ - - - 6.0 Glyceryl distearate - - - 9.5 glycerin - - - 6.0 water - - - 3.0 Nonylphenol polyglycine ether ² - - 5.0 - Undoped titanium dioxide 5.0 - - Octyl methoxycinnamate 5.0 - - - Fragrance & Others 1.0 1.0 1.0 1.0 2.0

¹ and the screen is about half the acetyl, Eastman Chemical Co. As Myvacet 7-07.

² Available as Hampshire Chemical Co., Hamplex TNP.

Example 28

The following ingredients are mixed to produce representative skin conditioning ingredients.

ingredient Example 28 Polydecene ¹ 53.3 Stearyl alcohol 7.7 12-hydroxystearic acid 13.5 Nonylphenol polyglycine ether 25.0 Octyl methoxycinnamate 1.5

¹ Puresyn 3000, Mobil Chemical Co.

Examples 29-31

The following ingredients are mixed to produce representative skin conditioning ingredients.

ingredient Example 29 Example 30 Example 31 glycerin 95.0 95.0 94.0 Decaglyceryl dipalmitate ¹ 5.0 1.0 5.0 Deceglyceryl dibehenate 4.0 Tribe henin 1.0

¹ Available as Polyaldo 10-2-P from Lonza

Examples 32-36

Representative conditioning components for the articles of the present invention are prepared in the following manner.

ingredient Example 32 Example 33 Example 34 Example 35 Example 36 Small Prize: SEFA ^* Cotonate 4.65 4.65 15.5 15.5 SEFA ^* Behenate 0.35 0.35 8.0 8.0 Tribe henin 6.0 6.0 Petro LeThem 4.0 4.0 4.4 Cocoa butter 15.5 C ₁₀ -C ₃₀ cholesterol / lanosterol ester 13.0 13.0 C ₃₀ -C ₄₅ alkyl methicone ¹ Polyglyceryl-4 isostearate (and) cetyl dimethicone (and) hexyl laurate ² 5.0 5.0 PEG 30 dipolyhydroxy stearate ³ 3.0 Tetraglyceryl monostearate 2.1 Decaglyceryl dipalmitate 0.90 Ceresin wax 5.5 Wax 7.0 Lecithin, refined 10.0 1-monostearin 10.0 Awards: glycerin 70.0 66.5 42.30 42.30 40.0 water 3.5 5.0 PVM / MA decadiene crosslinked polymer ⁴ 0.25 0.25 Sodium hydroxide (10% solution) 0.25 0.25 gelatin 2.6 Active skin care Ingredients: Panthenol 20.0 10.0 2.50 Nicotinamide 5.0 2.50 3.0 Element 5.0 2.50 2.50 Allantoin 0.20 0.20 Acetamidopropyltrimonium chloride 2.0

^* SEFA is an acronym for sucrose esters of fatty acids.

¹ Available as AMS-C30 from Dow Corning.

² Available as Abil WE-09 from Goldschmidt.

³ Available as Arlacel P135 from ICI.

⁴ Available as Stabileze 06 from ISP.

Process for all emulsions:

The bovine aqueous phase is heated to 70 ° C, the hydrophobic active skin care ingredients are added and stirred until homogeneous. The hydrophilic active skin care ingredients and the biodegradable ingredients are premixed and, if necessary, heated mildly to dissolve or disperse them. These are gradually added to the small water phase and stirring is continued. Homogenize (high shear mixer, ultrasonic homogenizer, or high pressure homogenizer, for example Microfluidizer from Microfluidics Corp.). Immediately apply to the surface of the substrate or cool rapidly from ice or ice water to room temperature. If necessary, store in a controlled environment under nitrogen for chemical stability.

Examples 37 to 41

Representative conditioning components are prepared as described in Examples 32-36 using the following components.

ingredient Example 37 Example 38 Example 39 Example 40 Example 41 Small Prize: SEFA * Cotonate 15.0 16.0 SEFA * Behenate 7.5 4.0 Tribe henin 6.0 Petro LeThem 4.0 4.0 4.4 Cocoa butter 15.5 Polydecene ¹ 50.0 46.5 C10-C30 cholesterol / lanosterol ester 13.0 10.5 PEG 30 dipolyhydroxy stearate 3.0 3.0 Ceresin wax 5.5 Wax 7.0 Mineral oil aluminum / magnesium hydroxystearate ² 7.5 C30-38 olefin / isopropyl maleate copolymer ³ 2.5 Polyethylene wax ⁴ 1.0 Tablets lecithin 10.0 Fragrances and other 1.0 1-monostearin 10.0 Awards: glycerin 30.0 25.0 34.80 20.0 38.0 water 8.0 8.0 5.0 PEG 2000 17.0 PVM / MA decadiene crosspolymer 0.25 Sodium hydroxide (10% solution) 0.25 gelatin 9.50 9.50 2.6 Active skin care Ingredients: Nicotinamide 2.50 Methanol in 50% beta cyclodextrin 2.50 Ascorbic acid (natural) 2.50 Tocopherol (natural) 1.00 2.50 Sorbitol 2.50 Lactic acid 2.5 Element 2.50 Allantoin 0.20 Triclosan 1.50 Chlorhexidine 0.50 Benzoyl peroxide 5.0 PPG 14 15% salicylic acid in butyl ether 12.0 Salicylic acid 2.5

¹ Available as Puresyn 3000 from Mobil

² Available from Giulini Chemie as Gilugel Min

³ Available as Performa 1608 from New Phase Technologies

⁴ Available from Performalene 400 from New Phase Technologies

Examples 42 to 46

Representative conditioning components are prepared as described in Examples 32-36 using the following components.

ingredient Example 42 Example 43 Example 44 Example 45 Example 46 Small Prize: SEFA * Cotonate 20.5 15.5 16.0 Mineral oil 7.50 SEFA * Behenate 8.0 8.0 8.0 Tribe henin 9.5 6.0 6.0 Petroretum (white or super-white) 4.0 4.0 22.6 3.0 4.0 Candelilla wax 4.50 Paraffin wax 3.00 14.0 Microcrystalline wax 1.50 Wax 3.00 C10-C30 cholesterol / lanosterol ester 18.0 13.0 13.0 Lauryl methicone copolyol ¹ 5.0 Acetylated monoglyceride ² 11.3 Stearyl alcohol 6.8 Cetyl alcohol 6.8 Stearic acid PEG 30 dipolyhydroxy stearate 4.5 3.0 Decaglyceryl dipalmitate ³ 0.90 Tetraglyceryl monostearate 2.10 Fragrance, other 1.0 3.0 2.0 Awards: glycerin 22.8 27.5 25.0 38.0 41.0 Decaglyceryl dipalmitate ³ 2.5 Calcium silicate microsphere ⁴ 15.0 Active skin care Ingredients: Guar hydroxypropyltrimonium chloride 1.00 Chitosan glycolate 2.50 Nicotinamide 1.50 2.50 2.50 0.2% Carbopol 940 aqueous solution, pH 6.0 38.0 Retinol 2.50 Pilot Triol ⁵ 1.00 Element 2.50 3.0 2.50 Vitamin C 2.50 Free Borage Oil 2.50 Ascorbyl palmitate 1.50 Acetamidopropyltrimonium chloride ⁶ 2.50

¹ Available as Dow Q2-5200 from Dow Corning

² Eastman Chemical Co. Available from Myvacet 7-07, almost half acetylated

³ Available as Polyaldo 10-2-P from Lonza

⁴ Celite Co. Available from Celite C

⁵ Available as Hydagen CMF from Henkel

Available from ⁶ Croda as Incromectant AQ

Example 43: Glycerin is incorporated into the microspheres, blended in a molten lipid, cooled during storage or applied to a substrate.

Examples 47 to 52

Representative conditioning components are prepared as described in Examples 32-36 using the following components.

ingredient Example 47 Example 48 Example 49 Example 50 Example 51 Example 52 Small Prize: SEFA * Cotonate 16.0 16.0 16.0 16.0 16.0 16.0 Mineral oil SEFA * Behenate 8.0 8.0 8.0 8.0 8.0 Tribe henin 6.0 6.0 6.0 6.0 6.0 6.0 Petroretum (white or super-white) 4.0 4.0 4.0 4.0 4.0 4.0 C10-C30 cholesterol / lanosterol ester 13.0 13.0 13.0 13.0 13.0 13.0 Stearyl dimethicone 2.0 Dimethicone hydroxystearate 4.0 Dimethicone copolyol behenate 2.0 PEG 30 dipolyhydroxy stearate 3.00 3.00 Sodium lauroyl glutamate 2.00 Sodium stearoyl lactylate 2.00 Calcium stearate 5.0 Decaglyceryl dipalmitate 0.90 0.90 0.90 0.90 Tetraglyceryl monostearate 2.10 2.10 2.10 2.10 Fragrance, other 1.00 1.00 1.00 1.00 1.00 1.00 Awards: glycerin 44.5 42.5 35.5 35.5 25.0 43.0 75% polyethylene imine ^{1 in} water, pH 6.5 4.50 4.50 water 2.0 Decaglyceryl dipalmitate 2.50 2.50 Fumed silica 20.0 Propylene glycol alginate ² 2.0 Active skin care Ingredients: Nicotinamide 2.00 2.00 Chitosan 1.50 Green tea extract 4.50 Aloe vera gel 3.0 Vitamin C 2.50 Ascorbyl palmitate 2.00 2.50 Acetamidopropyltrimonium chloride 2.00 2.00

¹ Nippon Shokubai Co. Available from Epomin SP-018

² Available as Kelcoloid HVF from Kelco

Examples 53 to 55

Representative conditioning components for the articles of the invention are prepared in the following manner.

ingredient Example 53 Example 54 Example 55 Small Prize: Tablet lecithin ¹ 15.4 10.3 10.8 Deccan 28.6 19.2 15.0 Mineral oil 5.0 Tricontanil PVP ² 26.0 Stearyl alcohol 13.0 12-hydroxystearic acid 19.4 Awards: glycerin 28.0 18.8 19.6 Propylene glycol 28.0 18.8 19.6 Active skin care Ingredients: Triclosan 0.20 Salicylic acid 0.40 Nicotinamide 4.0

¹ Available as Epikuron 200 from Lucas Meyer

² Available as Ganex WP-660 from ISP

All components are agitated together until a microemulsion is produced. The skin care ingredients are added to a phase that best fits their solubility parameter. When wax is added, it is slowly heated to the melting point of the wax, dispersed by stirring, added to the substrate or cooled at room temperature and stored.

Examples 56 to 58

Representative conditioning components for the articles of the invention are prepared according to the following method.

ingredient Example 56 Example 57 Example 58 Small Prize: Isohexadecane 42.29 43.0 28.3 Sodium dioctyl sulfosuccinate ² 10.62 7.0 7.1 Awards: glycerin 35.17 19.0 23.6 water 11.72 19.0 7.8 Carnauba wax 29.0 gelatin 6.0 Active skin care Ingredients: Triclosan 0.20 Titanium dioxide, for cosmetics 4.2 Titanium dioxide, fine powdered 4.2 Salicylic acid 1.8

¹ Available as Epikuron 200 from Lucas Meyer

² Available as Aerosol OT from Pfaltz and Bauer

First, the skin care ingredients are added to a phase that best fits their solubility parameter. Stir all constituents until a microemulsion is produced. Coated on the substrate surface.

Examples 59 to 64

Representative conditioning components for the articles of the invention are prepared in the following manner.

Part A Example 59 Example 60 Example 61 Example 62 Example 63 Example 64 Sodium lauroyl ether sulfate (added as a SLES 27% active) 15.0 6.51 6.20 5.9 Cocamidopropyl betaine ¹ 13.5 5.85 5.57 5.82 5.19 5.3 Sodium lauroyl sarcosinate ² 1.35 0.60 0.57 6.01 5.36 0.54 Decyl polyglucose ³ 5.80 5.18 Lauryl alcohol 1.31 0.56 0.54 0.54 Polyethylene imine ⁴ 7.87 3.38 3.22 2.64 2.36 3.2 Citric acid (added in 50% aqueous solution) 0.32 0.11 0.11 0.09 Tetrasodium EDTA 0.28 Sulfuric acid 5.4 2.37 2.25 2.2 Preservatives, fragrances 0.62 0.45 0.43 2.86 2.55 0.3 Sodium sulfate 7.9 3.47 3.21 3.0 glycerin 26.45 56.7 46.4 44.1 39.36 44.8 Sorbitol 5.0 SEFA * Cotonate 12.8 SEFA * Behenate 8.0 Part B - Polymer gelling agent gelatin 4.2 Polyacrylamide and isoparaffin ⁵ 7.5 Polyurethane latex in 50% isopropanol ⁶ 34.1 Polyacrylate Copolymer ⁷ 7.5 Polystyrene sulfonate copolymer ⁸ 1.1 Chitosan lactate 5.4 Part C - Physical Gelling Agent 12-hydroxystearic acid 10.0 10.66 Stearyl alcohol 10.0 20.0 20.0 7.11 15.0

* SEFA is an acronym for sucrose esters of fatty acids.

¹ Available as Tegobetaine F from Goldschmidt

^{2 available as} Hamposyl L-30 (type 721) from Hampshire Chemical, 31% active

³ Available as Plantaren 2000NP from Henkel

⁴ Nippon Shokubai Co. Available from Epomin SP-018, molecular weight approx. 1800

⁵ Available as Carbopol Ultrez from BF Goodrich

⁶ Available in Sancure 2710 from BF Goodrich, made with premixes containing about 20% polymer, 30% water and 50% IPA

⁷ Seppic Corp. Available from Sepigel 305

⁸ Available from AQ38S from Eastman Chemical

The surfactant and fatty alcohol are combined using a low speed impeller mixer while heating to 65 占 폚. Heat is removed and allowed to cool to 65 ° C while continuing to mix. The cationic polymer is added and stirred until homogeneous. The remaining part A is gradually added while stirring. Homogenize to disperse the SEFA as an emulsion. Titrate with concentrated sulfuric acid until the pH reaches about 6.5. The Part A composition is spread on a tray and dried in an appropriate (vacuum or convection) oven until no water remains at a temperature not exceeding 65 캜 to produce a dry mixture. The dried Part A component is combined with the polymeric gelling agent of Part B and heated to dissolve or disperse. The resulting composition is combined with a physical gelling agent. And the gelling agent is melted and dispersed in the composition by heating. Apply to substrate surface (s) or cool and store at room temperature.

Examples 65 to 70

Representative conditioning components for the articles of the invention are prepared as described in Examples 59-64 using the following components.

Part A Example 65 Example 66 Example 67 Example 68 Example 69 Example 70 Sodium lauroyl sarcosinate ¹ 8.87 11.4 10.8 10.8 Polyethylene imine ² 7.39 7.50 7.50 9.5 9.0 9.0 water 4.43 3.00 3.00 5.7 5.4 5.4 Sulfuric acid 6.36 QS QS 8.1 7.7 7.7 Fragrance, other glycerin 34.45 52.5 45.0 41.3 39.25 34.25 Propylene glycol 2.50 Element 2.50 2.50 2.0 1.9 1.9 Panthenol 2.0 1.9 1.9 Nicotinamide 2.50 2.50 2.0 1.9 1.9 Salicylic acid Polymethylsilsesquioxane ³ 4.20 4.20 Mica, pearl polish 3.85 3.85 Stearyl methicone wax 5.0 SEFA Cotonate 5.0 Petro LeThem 5.0 Part B - Polymer gelling agent gelatin 0.1 Polyacrylamide and isoparaffin ⁴ 16.0 12.0 12.0 Part C - Physical Gelling Agent 12-hydroxystearic acid 12.0 12.0 10.5 Carnauba wax 18.0 14.1 14.1 Stearyl alcohol 8.0 8.0 7.0

¹ Available as Hamposyl L-95 build from Hampshire Chemical

² Nippon Shokubai Co. Available from Epomin SP-018, molecular weight approx. 1800

³ Kobo. Inc. Available as Tospearl 145A from the company

⁴ Seppic Corp. Available from Sepigel 305

Examples 71-74

Representative skin conditioning ingredients comprising the following ingredients are prepared.

ingredient Example 71 Example 72 Example 73 Example 74 SEFA ^* Cotonate 62.0 52.0 Petrolatum 4.5 Stearyl alcohol 4.0 Stearic acid 3.0 lanolin 20.0 13.0 Ethylene Vinyl Acetate Polymer ¹ 10.0 10.0 Polydecene ² 2.0 2.0 Sodium lauroyl sarcosinate ³ 25.0 3.00 3.0 Lauryl betaine ⁴ 1.50 2.0 Lauroampho-acetate ⁵ 5.25 Sodium laureth-3 sulfate ⁶ 10.5 Cocamid MEA ⁷ 2.80 Sulfuric acid QS Guar hydroxypropyl-trimonium chloride 0.50 0.50 Cholesterol ⁸ 9.0 1.0 Nonylphenol polyglycine ether ⁹ 5.0 Fine-grained titanium dioxide 4.0 Octylmethoxy cinnamate 4.0 Nicotinamide 2.5 glycerin 10.0 3.00 water 48.5 55.95 PEG 6 capryl / capryglyceride 3.40 Maleated soybean oil 1.50 (Deodorized) soybean oil 8.0 Coconut fatty acid 2.60 Polyquaternium-10 0.40 Fragrances, preservatives, etc. 4.60

* SEFA is an acronym for sucrose esters of fatty acids.

¹ Available from Elpax 40W from DuPont

² Available as Puresyn 3000 from Mobil

³ Available as Hamposyl L95 (solid) or L30 (30% active in water) from Hampshire Chemical

⁴ Available as Empigen BS98 from Albright & Wilson (80% betaine, 20% salt)

⁵ Available from Empire CDL60 from Albright & Wilson

From ⁶ Albright & Wilson captured purchased Empicol ESC3 Available

⁷ Available as Empilan CME / G from Albright & Wilson

⁸ Available as Super Hartolan from Croda

⁹ Hampshire Chemical Co. Available as Hamplex TNP from the company

Dissolve the lipid components, add water and humectant (s) (if possible), add the surfactant, and continue to heat and stir until homogeneous. Cool to room temperature and add skin care activator (s) and deposition agent (s). The pH is adjusted to about 7.0 with sulfuric acid. Spray, roll, dip or otherwise apply to substrate and dry (if water is present) before packaging.

III. Personal care articles

Example 75

A representative skin cleansing article is prepared in the following manner.

4 g of the cleansing component of Example 11 is applied to one side of a permeable, fusible web composed of low melting heat-resistant synthetic polyamide fibers. The transmissive web is available from H. Levinson & Co., Chiago, IL as Wonder Under, manufactured by Pellon. Apply the cleansing composition to an oval area of about 13 cm x 18 cm. The cleansing ingredients are air dried. Place a 2 oz / yd ² polyester batting layer on the fusible web that is the same size as the web. The polyester bets consist of a combination of fibers having a basis weight of 2 oz / yd ² , at least a portion of which is crimped, with an average diameter of about 23 microns and 40 microns. The thickness of the betting is about 0.23 inches measured at 5 gsi. The betting is considered to be heat bonding without using an adhesive. The nonwoven fabric layer is disposed below the fusible web to form a second layer of the article. The nonwoven is a spunlace combination of 70% rayon and 30% PET fibers bonded with a styrene-butadiene adhesive, which is hydroapertured to form a hole with a diameter of about 2 mm, 70 gsm. The shape of the article is an oval of about 122 mm x 160 mm. The layers are sutured together using a point bond on a grid pattern with a heated suture die using a pressure platen thermal suture device such as a Sentinel Model 808 thermal suture machine from Sencorp (Hyannis, Mass.). Point bonding is measured at about 4 mm each, and about 51 individual sealing points are positioned in parallel. You can trim this item and use it immediately.

Example 76

A representative skin cleansing article is prepared in the following manner.

The cleansing component of Example 11 was measured by measuring the width across the web and was divided into four lines separated by a distance of 20 mm, 40 mm and 20 mm, And applied to one side of the first substrate. The cleansing component is extruded at a rate such that the cleansing component per article is 4.4 grams. The substrate is a spunlace mixture of 70% rayon and 30% PET fibers bonded with a styrene-butadiene adhesive, hydroformed to form about 2 mm diameter holes and has a basis weight of about 70 gsm. A second web, which is air-laid-out lofty low-density betting, is continuously supplied onto the first base material and placed in contact with the surfactant-containing layer. The batting contains a combination of 30 denier PET fibers of 15 denier, 35% of 3 denier bicomponent fibers of PET core and PE sheath, and 10 denier bicomponent fibers of the same core-cis composition, with a basis weight of about 100 grams (gsm). The web is continuously fed with an ultrasonic suturing machine which sutures with a dot pattern containing a grid of uniformly distributed 4 mm diameter suture points across the web. The web is cut into individual articles of approximately 120 mm x 160 mm rectangular size with rounded corners, with a total of about 51 seals per article.

Example 77

Representative skin cleansing and conditioning products are prepared in the following manner.

Three grams of the skin conditioning composition of Example 34 are applied to each side of the final article of Example 75, in half. The composition is applied by half-slot coating the composition on each side of the article uniformly on the surface of the article as a hot liquid (60-70 DEG C).

Example 78

Representative skin cleansing and conditioning products are prepared in the following manner.

Three grams of the skin conditioning composition of Example 18 is applied to each side of the final article of Example 75 in half. The composition is applied by half-slot coating the composition on each side of the article uniformly on the surface of the article as a hot liquid (60-70 DEG C).

Example 79

Representative skin cleansing and conditioning products are prepared in the following manner.

Three grams of the skin conditioning composition of Example 65 is applied to each side of the final article of Example 75 in half. The composition is applied by half-slot coating the composition on each side of the article uniformly on the surface of the article as a hot liquid (60-70 DEG C).

Example 80

Representative skin cleansing and conditioning products are prepared in the following manner.

Three grams of the skin conditioning composition of Example 34 is applied on each side of the final article of Example 76, in half. The composition is applied by half-slot coating the composition on each side of the article uniformly on the surface of the article as a hot liquid (60-70 DEG C).

Example 81

Representative skin cleansing and conditioning products are prepared in the following manner.

Three grams of the skin conditioning composition of Example 18 are applied to each side of the final article of Example 76, in half. The composition is applied by half-slot coating the composition on each side of the article uniformly on the surface of the article as a hot liquid (60-70 DEG C).

Example 82

Representative skin cleansing and conditioning products are prepared in the following manner.

Three grams of the skin conditioning composition of Example 65 is applied on each side of the final article of Example 76, in half. The composition is applied by half-slot coating the composition on each side of the article uniformly on the surface of the article as a hot liquid (60-70 DEG C).

Example 83

A representative skin cleansing article is prepared in the following manner.

The cleansing component of Example 11 was measured by measuring the width across the web and was divided into four lines separated by a distance of 20 mm, 40 mm and 20 mm, And applied to one side of the first substrate. The cleansing component is extruded at a rate such that 4.4 grams of cleansing component per end product is calculated. The substrate is an aqueous opening and forms a hole of about 2 mm diameter, with a basis weight of about 70 gsm, in a spunlace combination of 70% rayon and 30% PET fibers bonded with a styrene-butadiene adhesive. A second web, which is air-laid-out lofty low-density betting, is continuously supplied onto the first base material and placed in contact with the surfactant-containing layer. Betting contains a combination of 15 denier PET 30%, 3 denier bicomponent fibers of PET core and PE sheath 35%, and 10 denier bicomponent fibers of the same core-sheath composition 35%, with a basis weight of about 100 gsm. The web is continuously fed into an ultrasonic suture that sutures with a dot pattern, including a grid of 4 mm diameter suture points evenly distributed across the web. The web is cut into individual pieces of approximately 120 mm x 480 mm rectangular size with rounded corners.

Example 84

A representative skin cleansing article is prepared in the following manner.

The cleansing component of Example 11 was measured by measuring the width across the web and was divided into four lines separated by a distance of 20 mm, 40 mm and 20 mm, And applied to one side of the first substrate. The cleansing component is extruded at a rate such that 4.4 grams of cleansing component per end product is calculated. The substrate is a spunlaced mixture of 70% rayon and 30% PET fibers bonded with a styrene-butadiene adhesive, which is water-apertured to form pores with a diameter of about 2 mm and a basis weight of about 70 gsm. A second base web, which is air-laid-out lofted low-density betting, is continuously supplied onto the first base material and placed in contact with the surfactant-containing layer. The betting contains 30% of 15 denier PET fibers, 35% of 3 denier bicomponent fibers of PET core and PE sheath, and 35% of 10 denier fibers of the same core-cis composition, with a basis weight of about 100 gsm. A third substrate web identical to the second substrate web is continuously fed onto the second substrate web and placed in contact with the second substrate. The web is continuously fed with an ultrasonic suturing machine which sutures with a dot pattern containing a grid of uniformly distributed 4 mm diameter suture points across the web. Cut the web into individual pieces of approximately 120 mm x 90 mm rectangular size with rounded corners.

Example 85

A representative skin cleansing article is prepared in the following manner.

Four grams of the cleansing component of Example 12 is applied to one side of a permeable, fusible web comprising low melting heat-resistant synthetic polyamide fibers. The transmissive web is manufactured by Pellon, and is manufactured by H. Levinson & (Chicago, IL). Apply cleansing ingredients to oval areas of approximately 13 cm x 18 cm. The cleansing ingredients are air dried. A layer of 2 oz / yd ² polyester batting cut to the same size as the web is placed on the fusible web. The polyester bets have a basis weight of 2 oz / yd ² and include a fiber combination of about 23 microns and 40 microns average diameter, at least a portion of which is crimped. The thickness of the betting is about 0.23 in. to be. Batting has a air permeability of about 1270 and a foam permeability critical pressure (critical pressure) of about 2.7 cm H ₂ O in cfm / ft ^2. The betting is considered to be thermally bonded without the use of adhesives. The nonwoven layer is disposed below the fusible web to form the second side of the article. The nonwoven is a spun lace blend of 70% rayon and 30% PET fibers bonded with a styrene-butadiene adhesive, which is aqueous-apertured to form pores with a diameter of about 2 mm and a basis weight of about 70 gsm. The shape of the article is an ellipse of about 122 mm x 160 mm. The layers are squeezed together in a lattice pattern using a point bond with a thermal sealing die using a pressure-platen thermal sealing device such as a Sentinel Model 808 thermal sealer commercially available from Sencorp (Hyannis, Mass.). Point bonds are measured with diameters of about 4 mm each, and about 51 individual seams are uniformly distributed. You can use the product immediately after care.

Examples 86 to 88

With the cleansing ingredients of Examples 1, 2 and 5, representative skin cleansing products are prepared in the following manner.

Eight grams of the cleansing composition was applied to one side of a permeable, fusible web containing low melting heat-sealing synthetic fibers, leaving a space between the edges and quadrants so that the layer was sealed without surfactant, forming a rectangle of about 10 inches by 12 inches Apply in 4 quadrants. The permeable web is a fibrous low density polyethylene (LDPE or LLDPE) material that is usually marketed by the sewing supplier. A layer of 4 oz / yd ² polyester batting cut into the same size as the web is placed on the fusible web. The polyester bets have a basis weight of 4 oz / yd ² , consist of polyester fibers with an average diameter of about 30 microns, bonded with an adhesive, for example from Stearns Textiles (Cincinnati, Ohio) Mountain Mist Extra Heavy Batting # 205. A fibrous nonwoven layer having a basis weight of about 65 gsm and a wet tangle formulation of 55% cellulose and 45% polyester (available as Technicloth II from The Texwipe Company of Saddle River, NJ) is placed under the fusible web do. With a thermal seal die using a pressure platen thermal sealer such as the Sentinel Model 808 thermal sealer commercially available from Sencorp (Hyannis, Mass.), The batting melts and flows into the first layer to form a rectangle at a temperature and pressure sufficient to form the proper seal The layers are sutured together in a windowpane shape, usually at about 300 degrees Fahrenheit and 30 psi mechanical suture for 6 to 10 seconds. The suture has a single pane of glass cross-member that is continuous around the edges and presents a width of about 2 mm in each X- and Y-direction. After cooling, the article is trimmed and the corners rounded, keep it.

Examples 89 to 90

With the cleansing component powders of Examples 3 and 4, representative skin cleansing and conditioning products are prepared in the following manner.

Apply 4 grams of the dry cleansing component powder to one side of the permeable, fusible web containing the low melt heat sealing synthetic fibers. The transmissive web is manufactured by Pellon, H. Levinson & (Chicago, IL). Spray the powder uniformly on the ellipsoid of about 17 cm x 19 cm. A layer of 2 oz / yd ² polyester betting cut to the same size as the web is placed on the fusible web. The polyester bets have a basis weight of 2 oz / yd ² and include a fiber combination having an average diameter of about 23 microns and 40 microns, at least a portion of which is crimped. The thickness of the betting is about 0.23 in. to be. The betting has an air permeability of about 1270 cfm / ft ² and a foam permeability threshold pressure of about 2.7 cm H ₂ O. The betting is considered to be thermally bonded without the use of adhesives. A second nonwoven layer comprising an interlaced polypropylene scrim lace woven at a spacing of about 0.8 cm and having a fiber diameter of about 150 microns and containing about 10 micron diameter of polyester fibers, do. The second layer is cut larger than the required article size so that the X- and Y-axes of the layer are reduced to about 70 percent of their original size and the layer is about 0.12 in. Is placed in a convection oven for about 10 minutes at a temperature of about 150 degrees Celsius until it has a macroscopic thickness of about &lt; RTI ID = 0.0 &gt; The layer has a macroscopic average basis weight of about 64 gsm and an opening of about 0.5 mm average diameter before shrinkage. The second layer is placed under the fusogenic web, the layers are sealed together with point bonds, and the perimeter is sealed with a thermal suture die using a pressure platen thermal seal device such as the Sentinel Model 808 thermal sealer available from Sencorp (Hyannis, MA) Suture about 2 mm wide. The point bonds are each about 3 mm in diameter and about 51 individual seams are uniformly distributed. The composition was supplied through a slotted rolling apparatus with the article trimmed, the feed reservoir kept at about 60 DEG C and a machined 1.5 mm gap to provide 2.5 grams of the skin conditioning composition of Example 25 to the article Applies to lapped batting surfaces. The composition is rapidly cooled on the article surface and stored in a sealed metallized film package until use.

Examples 91 to 96

Representative skin cleansing and conditioning articles with the liquid cleansing ingredients of Examples 6, 8, 9, 15, 16 and 17 are prepared in the following manner.

Until the application of 2 grams of the solid cleansing component, the liquid cleansing component is coated with a brush in the form of a windowpane, excluding the edges and the sealing position, and applied to one side of the first substrate. The substrate is an aqueous opening and forms a hole of about 2 mm diameter, with a basis weight of about 70 gsm, in a spunlace combination of 70% rayon and 30% PET fibers bonded with a styrene-butadiene adhesive. The substrate is air dried in a convection oven at &lt; RTI ID = 0.0 &gt; 45 C &lt; / RTI &gt; for about 6 hours or until touched when touched. A second substrate, which is air-laid-out low-density betting, is placed on the first substrate and placed in contact with the surfactant-containing layer. Betting contains 30% of 15 denier PET fibers, 35% of 3 denier bicomponent fibers of PET core and PE sheath, and 35% of 10 denier bicomponent fibers of the same core-sheath composition, 100 grams (gsm). With a thermal seal die using a pressure platen thermal sealer such as the Sentinel Model 808 thermal sealer commercially available from Sencorp (Hyannis, Mass.), The batting melts and flows into the first layer to form a rectangle at a temperature and pressure sufficient to form the proper seal The layers are sutured together in the form of a windowpane, typically about 300 degrees Fahrenheit and 30 psi mechanical suture for 6 to 10 seconds. The suture has a single glazing cross member that is continuous around the edges and exhibits a width of about 2 mm in each X- and Y-direction. After cooling, the article was trimmed and the composition was fed through a slotted rolling device having a mechanized 1.5 mm gap and a feed reservoir maintained at about 60 DEG C to provide 3 grams of the skin conditioning composition of Example 26 to the lofted batting surface . The composition is rapidly cooled on the article surface and stored in a sealed metallized film package until use.

Examples 97 to 102

With the liquid cleansing ingredients of Example 7 and the skin conditioning compositions of Examples 19 to 24, representative skin cleansing and conditioning products are prepared in the following manner.

Four strips of liquid cleansing composition are successively extruded onto a mobile first web which is air-laid low-density betting. The batting contains 30% of 15 denier PET fibers, 35% of 3 denier bicomponent fibers of PET core and PE sheath, and 35% of 10 denier bicomponent fibers of the same core-sheath composition and has a basis weight per square meter Approximately 100 grams (gsm), air-bonded and thermally bonded without adhesive. The liquid cleansing components were heated to the melting point and stored in a storage tank at about 65 DEG C and fed to an extrusion head that continuously metered four cylindrical strands on a web at uniform intervals across the web to produce a composition of about 5 grams The final addition rate is achieved. A second web, which is a micro-opening and a macroscopically-shaped film, is a continuous supply of the web of US Pat. No. 4,629,643 on the male side of the macropore, which is the batting and cleansing component side on the first web. The skin conditioning composition is uniformly slot coated on the exposed betting surface in a hot state at a rate of about 3 grams of composition per final article, cooled on the article surface and allowed to solidify. The web is continuously sutured and cut into approximately 120 mm x 160 mm rectangles of rounded corners using a heated metal roll and a pressure roll applied to the formed film side. Pack the item until you use it.

Examples 103-105

With the liquid cleansing ingredients of Example 6 and the skin conditioning compositions of Examples 56, 57 and 58, representative skin cleansing and conditioning products are prepared in the following manner.

Until the application of 2 grams of solid surfactant, the liquid cleansing component is applied to the one side of the first substrate by brush coating the liquid cleansing component in the form of a window with the exception of the edge and sealing position. The substrate is an air-laid, low density batting containing 30% of 15 denier PET fibers, 35% of bicomponent fibers of PET core and PE sheath 3 denier, and 35% of 10 denier bicomponent fibers of the same core-sheath composition , And the basis weight is about 100 grams per square meter (gsm). Dry the cleansing ingredients. A second substrate, a high loft strength, adhesive bonded cellulose paper towel with excellent loft and a basis weight of about 53 gsm, is placed on the exposed surface of the cleansing component of the batting. A useful towel was the Bounty Rinse & Reuse manufactured by The Procter & Gamble Company, which retains its Z-direction height during wetting and has a thickness of about 0.047 inches at 5 gsi and a loft / . The layers are squeezed together into a rectangular pane of glass at a temperature and pressure sufficient to form a suitable seal with a thermal sealer using a pressure platen thermal sealer such as the Sentinel Model 808 thermal sealer commercially available from Sencorp (Hyannis, Mass.). And a single window sill intersecting member that continuously sutures around the edges and exhibits a width of about 2 mm in each X- and Y-direction. The composition is supplied through a slotted rolling apparatus with a feed reservoir and a mechanized 1.5 mm gap maintained at about 60 DEG C to trim the article and apply 1.5 grams of the skin conditioning composition to the lofted batting surface of the article. The composition is rapidly cooled on the article surface and stored in a sealed metallized film package until use.

Example 106

Representative skin cleansing and conditioning products are prepared in the following manner.

The cleansing components of Example 12 were measured by measuring the width across the web and were divided into four lines separated at a distance of 20 mm, 40 mm and 20 mm, And applied to one side of the first substrate. The cleansing component is extruded at a rate such that the cleansing component per end product is 4.4 grams. The substrate is a spun lace blend of 70% rayon and 30% PET fibers bonded with a styrene-butadiene adhesive, having an aqueous opening to form pores with a diameter of about 2 mm and a basis weight of about 70 gsm. The second substrate web, which is air-laid-out lofted low-density betting, is continuously fed over the first substrate and placed in contact with the surfactant layer. The bet includes a combination of 30% 15 denier PET fibers, 35% 3 denier bicomponent fibers of PET core and PE sheath, and 35% 10 denier bicomponent fibers of the same core-sheath composition, Is about 100 grams (gsm) per gram. A third substrate web identical to the second substrate web is continuously fed onto the second substrate web and placed in contact with the second substrate. The web is continuously fed with an ultrasonic suturing machine which sutures with a dot pattern containing a grid of uniformly distributed 4 mm diameter suture points across the web. The skin conditioning liquid of Example 53 is sprayed onto the web at a rate of about 25 gsm per side or at a rate of about 0.5 grams of composition per final article. The web is cut into individual pieces of approximately 120 mm x 90 mm rectangles of rounded corners and packaged until use.

Examples 107-108

Using the skin conditioning compositions of Examples 54 and 55, representative skin cleansing and conditioning products are prepared in the following manner.

The low water activity cleansing component of Example 2 was mixed with aluminosilicate (which generates heat due to an exothermic reaction upon exposure to water and is available as Advera 401 N from The PQ Corporation (Valley Forge, Pa.)) It is pulverized into three rolls at a ratio of 1: 1. Apply 10 grams of cleansing composition to one side of the batting layer. The batting consisted of an air-laid, lofty 30% denier PET fiber 30%, a combination of 3% denier bicomponent fibers of PET core and PE sheath 35%, and 10 denier bicomponent components of the same core- , Low density betting, and the basis weight is about 100 grams per square meter (gsm). The surfactant is applied to the fibers in four quadrants, which form a rectangle of about 10 inches by 12 inches, leaving a space between the edges and quadrants so that the layer is sealed without the presence of a surfactant. A polyester fiber having a diameter of about 10 microns and having a fiber diameter of about 100 microns for the width of the nonwoven fabric and about 250 microns perpendicular to the width therein and having a lace- ) &Lt; / RTI &gt; to produce a second nonwoven layer comprising a dead-end scrim. These scrims are commercially available from Conwed plastics (Minneapolis, MN). The second nonwoven has a basis weight of about 70 gsm and is slightly creped due to web tension during manufacture of the nonwoven and relaxation after stretching. The layer is sealed with a point bond and a 2 mm wide perimeter with a thermal suture die using a pressure platen thermal suture device such as a Sentinel Model 808 thermal suture device commercially available from Sencorp (Hyannis, Mass.). Point bonds each have a diameter of about 3 mm, and about 51 individual seams are uniformly distributed. The composition is supplied through a slotted rolling apparatus with a feed reservoir and a mechanized 1.5 mm gap maintained at about 60 DEG C to trim the article and apply 4 grams of the skin conditioning composition to the lofted batting surface of the article. The composition is rapidly cooled on the article surface and stored in a sealed metallized film package until use.

Examples 109 to 116

Using the skin conditioning compositions of Examples 59, 60, 61, 62, 63, 68, 69 and 70, representative skin cleansing and conditioning products are prepared in the following manner.

Four grams of the cleansing composition of Example 11 is uniformly sprayed by hand throughout the batting of the loft. The bet includes a combination of 30% of 15 denier PET fibers, 35% of 3 denier bicomponent fibers of PET core and PE sheath, and 35% of 10 denier bicomponents of the same core-sheath component, About 100 grams (gsm). A fibrous nonwoven layer having a basis weight of about 65 gsm and a wet tangled combination of 55% cellulose and 45% polyester (available from Technicloth II at Texwipe Company (Saddle River, NJ) Place over the coated surface. The layers are sutured together using an interlocking suture plate using a non-heated plate with an inverted thimble-shaped reservoir uniformly distributed in a hexagonal lattice pattern. The thimble reservoir is about 1.2 cm in diameter at the base and about 2 cm from the center-center lobe. The land portion between the dimples on the non-heated plate is recessed to within a few millimeters to form a trough connected to each other. The heating plate has an external ridge that exactly fits over the land portion of the non-heated plate. The heating plate is contacted with a cellulose / polyester substrate and heat sealed using a pressure platen thermal sealer such as a Sentinel Model 808 thermal sealer commercially available from Sencorp (Hyannis, Mass.). The resulting unfinished article has a striking thimble shape with the batting surface elevated and a shorter dimple or " button " with the cellulose / polyester substrate side of the article up, making both sides easier to hold. Cut the article into a rectangle approximately 120 mm x 160 mm. Three grams of the skin conditioning composition per article is pipetted into the dent area while the composition is hot, allowed to cool and solidify. Pack the item until you use it.

Example 117

Representative skin cleansing and conditioning products are prepared in the following manner.

Example 8 The liquid cleansing component of Example 10 Cleansing Ingredient 8 grams was divided into four quadrants, forming a rectangle about 10 inches x 12 inches, leaving a space between the edges and quadrants so that the layer was sealed without a surfactant, &Lt; / RTI &gt; is applied to one side of the permeable, fusible web. The permeable web is a fibrous low density polyethylene (LDPE or LLDPE) material that is usually marketed by the sewing supplier. The composition is dried. A layer of 4 oz / yd ² polyester batting cut into the same size as the web is placed on the fusible web. The polyester batt has a basis weight of 4 oz / yd ² and is composed of polyester fibers having an average diameter of about 30 microns and is bonded with an adhesive, for example, Mountain Mist Extra Heavy Batting # 2 from Stearns Textiles, Cincinnati, 205 &lt; / RTI &gt; A fibrous nonwoven layer having a basis weight of about 65 gsm and a wet tangle formulation of 55% cellulose and 45% polyester (available as Technicloth II from Texwipe Company (Saddle River, NJ)) is placed under the fusogenic web . With a thermal seal die using a pressure platen thermal sealer such as the Sentinel Model 808 thermal sealer commercially available from Sencorp (Hyannis, Mass.), The batting melts and flows into the first layer to form a rectangle at a temperature and pressure sufficient to form the proper seal The layers are sutured together in the form of a windowpane, usually at 300 degrees Fahrenheit and 30 psi mechanical compression for 6 to 10 seconds. The suture has a single glazing cross member that is continuous around the edges and exhibits a width of about 2 mm in each X- and Y-direction. Five grams of the conditioning composition of Example 64 is applied to each side of the article in half by brush, and the article is dried again. Keep the items trimmed, rounded corners, and stored until use.

Examples 118-119

Using the skin cleansing compositions of Examples 66 and 67, representative skin cleansing and conditioning products are prepared in the following manner.

The liquid cleansing component of Example 15 is applied to the first substrate by dipping into a bath of composition until the 120 mm x 160 mm section of the substrate has increased its weight to about 8 grams. The base material contains 30% of 15 denier PET fibers, 35% of 3 denier bicomponent fibers of PET core and PE sheath, and 35% of bicomponent fibers of 10 denier of the same core-sheath composition, About 100 grams (gsm). The substrate is dried. With a spunlace combination of 70% rayon and 30% PET fibers bonded with a styrene-butadiene adhesive, to form apertures of about 2 mm in diameter in an aqueous opening and to form pieces of a second substrate having a basis weight of about 70 gsm, Is placed on a substrate. The substrates are sutured together using an ultrasonic suturing machine which sutures with a dot pattern containing a grid of 4 mm diameter sealing points uniformly distributed throughout the article. The composition is fed through a slotted rolling apparatus having a feed reservoir maintained at about 60 DEG C and a mechanized 1.5 mm gap to uniformly apply 4 grams of the skin conditioning composition across both sides of the article. The composition is rapidly cooled on the article surface and stored in a sealed metallized film package until use.

Examples 120 to 124

Using the skin conditioning compositions of Examples 27 to 31, representative skin cleansing and conditioning products are prepared in the following manner.

The cleansing component of Example 11 was measured by measuring the width across the web and was divided into four lines separated by a distance of 20 mm, 40 mm and 20 mm, And applied to one side of the first substrate. The cleansing component is extruded at a rate such that 4.4 grams of cleansing component per end product is calculated. The substrate is an aqueous opening and forms a hole of about 2 mm diameter, with a basis weight of about 70 gsm, in a spunlace combination of 70% rayon and 30% PET fibers bonded with a styrene-butadiene adhesive. A second base web, which is an air-laid lofted low density polyester batting, is continuously supplied onto the first base material, and placed in contact with the surfactant-containing layer. The batting contains 30% of 15 denier PET fibers, 35% of 3 denier bicomponent fibers of PET core and PE sheath, and 35% of 10 denier bicomponent fibers of the same core-sheath composition and has a basis weight per square meter About 100 grams (gsm). A third substrate web identical to the second substrate web is continuously fed onto the second substrate web and placed in contact with the second substrate. The web is continuously fed with an ultrasonic suturing machine which sutures with a dot pattern containing a grid of uniformly distributed 4 mm diameter suture points across the web. Slot coating of the skin conditioning composition on both sides of the substrate (approximately 140 gsm per side) at the same rate as 3 grams of the skin conditioning composition per final article, from the hot reservoir pumped through the slot dye, The cooling fan is passed through to cool rapidly on the surface. Cut the web into individual pieces of approximately 120 mm x 90 mm rectangular size with rounded corners.

Examples 125-145

Using the skin conditioning compositions of Examples 32 to 52, representative skin cleansing and conditioning articles are prepared in the following manner.

The cleansing component of Example 11 was measured by measuring the width across the web and was divided into four lines separated by a distance of 20 mm, 40 mm and 20 mm, And applied to one side of the first substrate. The cleansing component is extruded at a rate such that the cleansing component per end product is 4.4 grams. The substrate is a spun lace blend of 70% rayon and 30% PET fibers bonded with a styrene-butadiene adhesive, having an aqueous opening to form pores with a diameter of about 2 mm and a basis weight of about 70 gsm. A second base web, which is air-laid-out lofted low-density betting, is continuously supplied onto the first base material and placed in contact with the surfactant-containing layer. The batting includes a combination of 15 denier PET 30%, 3 core denier bicomponent fibers of PE core and PE sheath 35%, and 10 core denier bicomponent fibers of the same core-sheath composition 35% About 100 grams (gsm). A third substrate web identical to the second substrate web is continuously fed onto the second substrate and placed in contact with the second substrate. The web is continuously fed with an ultrasonic suturing machine which sutures with a dot pattern containing a grid of uniformly distributed 4 mm diameter suture points across the web. Slot-coating the skin conditioning composition from both sides of the substrate (about 140 gsm per side) at the same rate as 3 grams of the skin conditioning composition per final article, from the hot reservoir pumped through the slot dye, The cooling fan is quickly passed through the cooling fan. Slot coating reservoirs are continuously mixed to maintain the stability of the emulsion. Cut the web into individual pieces of approximately 120 mm x 90 mm rectangular size with rounded corners.

Examples 146 to 147

Using the skin cleansing and conditioning compositions of Examples 71 and 74, representative skin cleansing and conditioning products are prepared in the following manner.

The first substrate and the second substrate are cut into approximately 12 inches by 9 inches rectangles. The first substrate is an aqueous opening to form a hole of about 2 mm diameter, with a basis weight of about 70 gsm, in a spunlace combination of 70% rayon and 30% PET fibers bonded with a styrene-butadiene adhesive. The second substrate contains 30% of 15 denier PET fibers, 35% of 3 denier bicomponent fibers of PET core and PE sheath, and 35% of 10 denier bicomponent fibers of the same core-sheath composition, Is about 100 grams (gsm) per beat. With a thermal sealing die using a pressure platen thermal sealer such as a Sentinel Model 808 thermal sealer commercially available from Sencorp (Hyannis, Mass.), The batting melts and flows into the first layer to form a square at a temperature and pressure sufficient to form the proper seal Squeeze the substrates together in the form of a windowpane and usually have a mechanical pressure of 300 degrees Fahrenheit and 30 psi for 6 to 10 seconds. The suture has a single glazing cross member that is continuous around the edges and exhibits a width of about 2 mm in each X- and Y-direction. After cooling, the article is trimmed to about 11 inches x 8.5 inches, and 10 grams of the skin cleansing and conditioning composition is applied to the outer surface of both sides, about half of the composition per side. The composition is dried and stored until use.

Examples 148-149

Using the skin cleansing and conditioning compositions of Examples 72 and 73, representative skin cleansing and conditioning products are prepared in the following manner.

The first substrate and the second substrate are cut into a rectangle of about 12 inches by 9 inches. The first substrate is a spunlace blend of 70% rayon and 30% PET fibers bonded with a styrene-butadiene adhesive, which is water-apertured to form pores with a diameter of about 2 mm and a basis weight of about 70 gsm. The second substrate contains 30% of 15 denier PET fibers, 35% of 3 denier bicomponent fibers of PET core and PE sheath, and 35% of 10 denier bicomponent fibers of the same core-sheath composition, Is about 100 grams (gsm) per beat. With a thermal seal die using a pressure platen thermal sealer such as the Sentinel Model 808 thermal sealer commercially available from Sencorp (Hyannis, Mass.), The batting melts and flows into the first layer to form a rectangle at a temperature and pressure sufficient to form the proper seal Squeeze the substrates together in the form of a windowpane and usually have a mechanical pressure of 300 degrees Fahrenheit and 30 psi for 6 to 10 seconds. The suture has a single glazing cross member that is continuous around the edges and exhibits a width of about 2 mm in each X- and Y-direction. After cooling, the article is trimmed to about 11 inches by 8.5 inches, and 8 grams of skin cleansing and conditioning composition is applied to the heating reservoir, pump, on-off valve, slot head, and coating head maintained at about 70 ° C. System is slot-coated on the article with 4 grams per side, uniformly distributed over the article surface, using an XY table, a programmable metrology system. The composition is rapidly cooled on the surface of the article. Pack the item until you use it.

Examples 150-152

Representative skin cleansing and conditioning products are prepared by the following methods.

A liquid cleansing composition is prepared containing the following ingredients:

ingredient Example 150 Example 151 Example 152 Sodium laureate 3 sulfate 3.60 Sodium C13 / C14 methyl branched sulfate 5.00 5.60 4.50 Sodium paraffin sulfonate 6.40 Sodium alpha olefin sulphonate 5.20 Sodium lauryl sulfate 5.50 Sodium lauroamphoacetate 4.50 5.30 3.65 Cocamide MEA 3.55 3.20 2.80 Suche mountain 2.80 5.70 6.00 Sodium succinate 0.10 0.14 0.30 Citric acid 3.00 4.30 5.00 Sodium citrate 1.60 1.10 1.40 Malonic acid 4.00 2.20 glycerin 10.00 15.00 8.50 Coconut 12-18 fatty acids 2.00 3.00 Spices 1.00 1.20 1.00 MgSO ₄ -7H ₂ O 0.89 0.90 0.80 water 54.21 47.61 52.25 Salicylic acid 1.85 Triclosan 0.25 Trichlorocarbanilide 1.10 Zinc pyrithione 2.00

The cleansing composition is applied to one side of the first substrate by brushing to one side of the substrate until 10 grams of cleansing composition is added to the 11 inch by 8.5 inch area. The base material contains 30% of 15 denier PET fibers, 35% of 3 denier bicomponent fibers of PET core and PE sheath, and 35% of 10 denier bicomponent fibers of the same core-sheath composition and having a basis weight of about 100 gsm , And a lofty low-density bet. The first substrate is dried. The second substrate is laminated to the untreated side of the first substrate using an ultrasonic suture which sutures with a dot pattern comprising a grid of 4 mm diameter sealing points uniformly distributed at 2 cm intervals across the web. The second substrate is an aqueous opening to form a hole of about 2 mm diameter, with a basis weight of about 70 gsm, in a spunlace combination of 70% rayon and 30% PET fibers bonded with a styrene-butadiene adhesive. The skin conditioning composition of Example 19 was uniformly slot coated on the entire surface of the second substrate at a rate of about 3 grams of composition per article, allowed to cool, and packaged until use. The article provides sustained antiviral, antifungal and antibacterial activity for both gram negative and gram positive organisms, is well foamed, and relatively mild to the skin.

Example 153

Representative skin cleansing and conditioning products are prepared in the following manner.

4 g of the cleansing component of Example 11 was spread evenly by hand on the luffed batting. The betting is a 4 oz / yd ² polyester batting, containing polyester fibers having an average diameter of about 30 microns and cut to a size of 130 mm x 175 mm, bonded with an adhesive, for example Stearns Textiles (Cincinnati, OH) In Mountain Mist Extra Heavy Batting # 205. A fibrous nonwoven layer having a basis weight of about 65 gsm and a wet tangle formulation of 55% cellulose and 45% polyester (available as Technicloth II from Texwipe Company (Saddle River, NJ)) was applied to the surface of the surfactant- . The layers are sutured together using an interlocking suture plate using an unheated plate with an inverted oval-shaped reservoir uniformly positioned in a hexagonal grid pattern. The omentum reservoirs are about 1.2 cm in diameter at the base and about 1.5 cm in the center. The area between the dimples on the unheated plate is raised several millimeters convex to form a connecting ridge. The heated plate has an outer trough that exactly fits the ridge of the unheated plate. The heated plate is brought into contact with the cellulosic / polyester substrate and heat sealed using a pressure platen thermal sealing device such as a Sentinel Model 808 thermal sealer commercially available from Sencorp (Hyannis, MA). The resulting unfinished article has a topographical trait that assists foam production on both sides and also makes it easier to grasp and slip on the skin surface during use. Cut the article into a rectangle approximately 120 mm x 160 mm.

Skin Conditioning A reverse emulsion paste is prepared for use with the article, as follows:

ingredient percentage PEG 30-dipolyhydroxy stearate 3.0 SEFA Cotonate 20.0 Petrolatum 4.0 Tribe henin 5.0 C10-C30 cholesterol / lanosterol ester 13.0 SEFA Behenate 5.0 glycerin 50.0

The lipid solubility content is heated to &lt; RTI ID = 0.0 &gt; 70 C &lt; / RTI &gt; Glycerin is slowly added with vigorous stirring. The composition becomes homogeneous. Pipette 3 g of hot skin conditioning reverse emulsion paste into the recessed portion of the cellulose / polyester side of the article. The composition is rapidly cooled with a semi-solid paste. Pack the item until you use it.

Examples 154-158

Using the skin conditioning compositions of Examples 19, 29, 34, 55 and 60, representative skin conditioning products are prepared in the following manner.

The conditioning composition was applied to four strips of 5 mm width each, separated by a distance of 20 mm, 40 mm and 20 mm, respectively, by measuring the width across the web, And then continuously extruded through a coating head to be applied to one side of the first substrate. The composition is extruded at a rate to produce 3 grams of composition per final article. The substrate is a spun lace blend of 70% rayon and 30% PET fibers bonded with a styrene-butadiene adhesive, having an aqueous opening to form pores with a diameter of about 2 mm and a basis weight of about 70 gsm. A second substrate web, which is an air-laid lofted low density bet, is continuously fed across the first substrate and placed in contact with the first substrate and the side not containing the skin conditioning composition. The bet includes a combination of 30% 15 denier PET fibers, 35% 3 denier bicomponent fibers of PET core and PE sheath, and 35% 10 denier bicomponent fibers of the same core-sheath composition, Is about 100 grams (gsm) per gram. The web is continuously fed with an ultrasonic suturing machine which sutures with a dot pattern containing a grid of uniformly distributed 4 mm diameter suture points across the web. The web is cut into individual articles of approximately 120 mm x 160 mm rectangular size with rounded corners, with a total of about 51 seals per article.

Examples 159 to 163

Using the skin conditioning compositions of Examples 19, 28, 34, 55 and 69, representative skin conditioning articles are prepared in the following manner.

The conditioning composition was applied to four strips of 5 mm width each, separated by a distance of 20 mm, 40 mm and 20 mm, respectively, by measuring the width across the web, And then continuously extruded through a coating head to be applied to one side of the first substrate. The composition is extruded at a rate to produce 1.1 grams of composition per final article. The substrate is a spun lace blend of 70% rayon and 30% PET fibers bonded with a styrene-butadiene adhesive, having an aqueous opening to form pores with a diameter of about 2 mm and a basis weight of about 70 gsm. A second substrate web, which is an air-laid lofted low density bet, is continuously fed across the first substrate and placed in contact with the first substrate and the side not containing the skin conditioning composition. The batting includes a combination of 10% of 15 denier PET fibers, 50% of 3 denier bicomponent fibers of PET core and PE sheath, and 40% of 10 denier bicomponent fibers of the same core-sheath composition, About 80 grams (gsm). The web is continuously fed with an ultrasonic suturing machine which sutures with a dot pattern containing a grid of uniformly distributed 4 mm diameter suture points across the web. The web is cut into individual articles about 120 mm x 90 mm rectangular in size with rounded corners, with a total of about 51 seals per article. The article is convenient for application to narrower areas of the skin, such as the face, elbow, neck and / or feet.

Example 164

A representative skin cleansing article is prepared in the following manner.

The cleansing component of Example 11 was measured by measuring the width across the web and was divided into four lines separated by a distance of 20 mm, 40 mm and 20 mm, And applied to one side of the first substrate. The cleansing component is extruded at a rate such that 0.40 grams of cleansing component per end product is calculated. The substrate is a spun lace blend of 70% rayon and 30% PET fibers bonded with a styrene-butadiene adhesive, having an aqueous opening to form pores with a diameter of about 2 mm and a basis weight of about 70 gsm. A second substrate web, air-laid-out lofted low-density betting, is continuously fed over the first substrate and placed in contact with the surfactant layer. The bet includes a combination of 15% denier PET fibers 10%, 3% denier bicomponent fibers of PET core and PE sheath 50%, and 10 denier bicomponent fibers of the same core-sheath composition 40% Is about 80 grams (gsm) per gram. A third substrate web identical to the second substrate web is continuously fed onto the second substrate web and placed in contact with the second substrate. The web is continuously fed with an ultrasonic suturing machine which sutures with a dot pattern containing a grid of uniformly distributed 4 mm diameter suture points across the web. Cut the web into individual pieces of approximately 120 mm x 90 mm rectangular size with rounded corners.

Examples 165 to 169

Representative skin cleansing and conditioning articles are prepared using the skin conditioning compositions of Examples 19, 28, 34, 55 and 69.

The cleansing component of Example 11 was measured by measuring the width across the web and was divided into four lines separated by a distance of 20 mm, 40 mm and 20 mm, And applied to one side of the first substrate. The cleansing component is extruded at a rate such that 0.52 grams of cleansing component per end product is calculated. The substrate is a spun lace blend of 70% rayon and 30% PET fibers bonded with a styrene-butadiene adhesive, having an aqueous opening to form pores with a diameter of about 2 mm and a basis weight of about 70 gsm. A second substrate web, air-laid-out lofted low-density betting, is continuously fed over the first substrate and placed in contact with the surfactant layer. The batting includes a combination of 10% of 15 denier PET fibers, 50% of 3 denier bicomponent fibers of PET core and PE sheath, and 40% of 10 denier bicomponent fibers of the same core-sheath composition, About 80 grams (gsm). A third substrate web identical to the second substrate web is continuously fed onto the second substrate web and placed in contact with the second substrate. The web is continuously fed with an ultrasonic suturing machine which sutures with a dot pattern containing a grid of uniformly distributed 4 mm diameter suture points across the web. Slot coating the skin conditioning composition on both sides of the substrate (about 55 gsm per side) at the same rate as 1.25 grams of the skin conditioning composition per final article from the hot reservoir pumped through the slot dye, The cooling fan is passed through to cool rapidly on the surface. Cut the web into individual pieces of approximately 120 mm x 90 mm rectangular size with rounded corners.

Example 170

Representative skin cleansing and conditioning kits are prepared in the following manner.

A skin cleansing article is produced. The cleansing component of Example 11 was measured by measuring the width across the web and was divided into four lines separated by a distance of 20 mm, 40 mm and 20 mm, And applied to one side of the first substrate. The cleansing component is extruded at a rate such that 4.4 grams of cleansing component per end product is calculated. The substrate is an aqueous opening and forms a hole of about 2 mm diameter, with a basis weight of about 70 gsm, in a spunlace combination of 70% rayon and 30% PET fibers bonded with a styrene-butadiene adhesive. The second web, which is air-laid-out lofted low-density betting, is continuously supplied onto the first base material and placed in contact with the surfactant-containing layer. The batting contains 30% of 15 denier PET fibers, 35% of 3 denier bicomponent fibers of PET core and PE sheath, and 35% of 10 denier bicomponent fibers of the same core-sheath composition and has a basis weight per square meter About 100 grams (gsm). The web is continuously fed with an ultrasonic suturing machine which sutures with a dot pattern containing a grid of uniformly distributed 4 mm diameter suture points across the web. Cut the web into individual pieces of approximately 120 mm x 480 mm rectangular size with rounded corners.

To produce a skin conditioning article. The conditioning composition of Example 34 was applied to four strips each separated by a distance of 20 mm, 40 mm and 20 mm, measuring width of 5 mm width and web width, respectively, and a line parallel to each side of the web Are continuously extruded through a coating head so as to be applied to one side of the first substrate. The composition is extruded at a rate to produce 3 grams of composition per final article. The substrate is an aqueous opening and forms a hole of about 2 mm diameter, with a basis weight of about 70 gsm, in a spunlace combination of 70% rayon and 30% PET fibers bonded with a styrene-butadiene adhesive. The second web, which is air-laid-out low-density betting, is continuously fed over the first substrate and placed in contact with the first substrate and the side not including the skin conditioning composition. The bet includes a combination of 30% of 15 denier PET fibers, 35% of 3 denier bicomponent fibers of PET core and PE sheath and 35% of 10 denier bicomponent fibers of the same core-sheet composition, and about 100 grams per square meter gsm). The web is continuously fed with an ultrasonic suturing machine which sutures with a dot pattern containing a grid of uniformly distributed 4 mm diameter suture points across the web. The web is cut into individual articles of approximately 120 mm x 160 mm rectangular size with rounded corners, with a total of about 51 seals per article.

Skin cleansing items and skin conditioning products are packaged together in a single package.

Example 171

Representative skin cleansing and conditioning kits are prepared in the following manner.

A skin cleansing article is produced. The cleansing component of Example 11 was measured by measuring the width across the web and was divided into four lines separated by a distance of 20 mm, 40 mm and 20 mm, And applied to one side of the first substrate. The cleansing component is extruded at a rate such that 4.4 grams of cleansing component per end product is calculated. The substrate is an aqueous opening and forms a hole of about 2 mm diameter, with a basis weight of about 70 gsm, in a spunlace combination of 70% rayon and 30% PET fibers bonded with a styrene-butadiene adhesive. A second web of air-laid-out lofted low density betting is continuously fed onto the first substrate and placed in contact with the surfactant layer. The batting contains 30% of 15 denier PET fibers, 35% of 3 denier bicomponent fibers of PET core and PE sheath, and 35% of 10 denier bicomponent fibers of the same core-sheath composition and has a basis weight per square meter About 100 grams (gsm). The web is continuously fed with an ultrasonic suturing machine which sutures with a dot pattern containing a grid of uniformly distributed 4 mm diameter suture points across the web. Cut the web into individual pieces of approximately 120 mm x 480 mm rectangular size with rounded corners.

To produce a skin conditioning article. A substrate is produced which is a wet tangling blend of fibers having a softer and finer denier fiber on one side and a more coarse fiber on the other side. Two webs each having a basis weight of about 20 gsm and containing 10 denier polyester (PET) fibers are air laid on top of one web to produce a substrate. A web of rayon-woven polypropylene scrim having a diameter of about 100 microns and spacing about 0.8 cm apart is fed as a third web onto the fibrous web. A fourth web and a fifth web comprising three denier polyester fibers are air laid at about 20 gsm on top of the web, respectively. The web is wet-knotted and fixed in a single web unit and dried on a dry can until moisture is removed and about 20% reduction due to relaxation of the scrim occurs. By applying a kiss roll at a wet addition rate rate of about 7 gsm, a low T _g (about 5 ° C) waterborne acrylic adhesive co-polymer is added to the rough fiber side of the web and dried. The skin conditioning composition of Example 21 is continuously added to the web by uniformly slot coating the composition on both sides of the web at a rate of about 25 gsm per side. A high temperature cutting roll is used to cut the scrim fibers slightly from the edge of the article when cut, thereby cutting the substrate web into individual articles about 120 mm x 100 mm square in size with rounded corners.

Skin cleansing items and skin conditioning products are packaged together in a single package.

Example 172

Representative skin cleansing and conditioning products are prepared in the following manner.

Thereby preparing a first substrate. The first substrate contains 30% of 15 denier PET fibers, 35% of 3 denier bicomponent fibers of PET core and PE sheath, and 35% of 10 denier bicomponent fibers of the same core-sheath composition, It is an air-mounted, lofty low density betting that is about 100 grams per gsm. The batting is embossed with a shaped, heated embossing roll to form an engraved area surrounded by raised, button-like repeating units, shaped similarly to a bulb, and forming a material representing the hook portion of the hook- It leaves. Such materials are available from PGI Nonwovens, Benson, NC. 4.4 g of the skin cleansing composition of Example 11 is applied uniformly to the backside (flat side) of a 10 inch by 8.5 inch rectangle of the first substrate. Bonded to a cellulose paper towel and cut to a size of about 10 inches x 8.5 inches by a second substrate of a lofty high wetting force with a basis weight of about 53 gms. Useful towels are available from The Procter & Gamble Company, Bounty Rinse & Reuse , Which maintains its Z-direction height upon wetting, has a thickness of about 0.047 inches at 5 gsi, a loft / soft ratio of about 1.28, and a high crepe ratio by wet-forming on the shaped belt . Using a pressure platen-type heat sealer such as a Sentinel Model 808 heat sealer available from Sencorp (Hyannis, Mass.), The substrate was placed on the edge and the center of the article at 4 dots (5 mm diameter, uniformly spaced from each other and nearest edge) Heat suture. The article is trimmed, and 3 g of the 18 skin conditioning composition is applied to both sides of the article and applied at high temperature. Allow the item to cool down and pack until used.

Claims (11)

A substantially dry, disposable personal care article, characterized by comprising: a) a water-insoluble substrate containing a nonwoven layer; And b) a therapeutic efficacious composition comprising a hydrophilic conditioning agent exhibiting a leaching value of less than 25% at 1 minute and less than 50% at 5 minutes when the article is exposed to water, % &Lt; / RTI &gt; to 1000% by weight of a therapeutically effective agent, the therapeutic efficacy component being disposed proximate to the water insoluble substrate. The article of claim 1, wherein the nonwoven layer comprises fibers selected from the group consisting of natural fibers, synthetic fibers, and combinations thereof. The article of claim 1 or 2, wherein the fibers are synthetic fibers selected from the group consisting of nylon fibers, rayon fibers, polyolefin fibers, polyester fibers, and combinations thereof. The article of any one of claims 1 to 3, wherein the nonwoven layer comprises a material selected from the group consisting of a cellulosic nonwoven, a sponge, a molded film, a batting, and combinations thereof. 5. The article of any one of claims 1 to 4, wherein the therapeutic efficacy composition is selected from the group consisting of a hydrophilic conditioning agent, a hydrophobic conditioning agent, and combinations thereof. 6. The article of any one of claims 1 to 5 wherein the therapeutic efficacy composition is a micro-emulsion. 7. The article of any one of claims 1 to 6, wherein the therapeutic efficacy composition is a coacervate-forming composition. 8. The composition according to any one of claims 1 to 7, wherein the therapeutic efficacy component is selected from the group consisting of a vitamin compound, a skin treatment agent, an anti-acne active ingredient, an anti-wrinkle active ingredient, The present invention also relates to a pharmaceutical composition comprising at least one active ingredient selected from the group consisting of a topical anesthetic, a topical anesthetic, an artificial tanning active ingredient and an accelerator, an antimicrobial active ingredient, an antifungal active ingredient, an antiviral agent, an enzyme, a sunscreen active ingredient, an antioxidant, a skin stripping agent, a hydrophobic conditioning agent, &Lt; RTI ID = 0.0 &gt; a &lt; / RTI &gt; combination thereof. A method for the therapeutic treatment of skin and / or hair, comprising the steps of: a) wetting the article of paragraph 1; b) bringing the skin and / or hair into contact with the wetted article. 10. An article according to any one of claims 1 to 9, further comprising a lathering surfactant. CLAIMS What is claimed is: 1. A method of cleansing skin and / or hair comprising: a) wetting the article of claim 10; And b) bringing the skin and / or hair into contact with the wetted article.