KR20020004505A - Method for Packaging Drug-based Medicine and Dual Package System thereof - Google Patents

Abstract

PURPOSE: A packing method for drug type medical supplies and dual packing system thereof are provided to prevent the damage of the wrapping state in the procedure of transfer or treatment for preventing the illegal use of the drug type medical supplies. CONSTITUTION: A packing method for drug type medical supplies includes the steps of preparing a plastic ampule(10) by sealing at an upper end of a molded plastic container after filling with medical supplies, and sealing a film container(30) at three sealing portions(31-33) after injecting the ampule and filling inert gas inside, wherein the plastic ampule is formed in series of molding, filling and sealing steps, the wrapping container is made with an oxygen-blocking three-side wrapping paper, and the inert gas is to be nitrogen gas(40).

Description

Method for Packaging Drug-based Medicine and Dual Package System

The present invention relates to a dual packaging method and a dual packaging system of a medicine, which must be extremely careful in handling and use, such as drug products.

Narcotic substances may ultimately have a harmful effect on humans and are therefore prohibited by law. However, there are cases in which medical treatments are inevitably used as medicines, and each country puts a lot of restrictions on the handling and use of narcotic medicines.

Therefore, the use of drugs is limited to special institutions such as hospitals, and all processes such as production, transportation, sale, and disposal are supervised by the government. For example, all processes including import of raw materials, manufacture of injectables, and sale must be approved by the government, and all processes including import volume, date of import, distribution of pharmaceutical companies, manufacture of injectables, sales volume, source of use, and subject of administration are documented and reported in the information. It is regulated and kept in a safe.

Narcotics drugs are usually distributed and used in glass ampoules, sealed and packaged. However, glass ampoules are easily broken during distribution and handling, and due to the nature of drug products, the glass ampoules are strictly managed by the government. Because it has to go through a complicated process, it is disturbing many other tasks.

In addition, there are many cases in which some handlers intentionally break a glass ampoule after illegally using the contents and disguise it as being damaged during distribution or handling.

Therefore, there is an urgent need for a solution to this problem, namely, that there is a high risk of damage in distribution and handling and that the contents can be illegally used and concealed.

Therefore, an object of the present invention is to solve these problems at once and to solve technical problems that have been requested from the past.

That is, the packaging of narcotic medicines is manufactured with plastic ampoules to eliminate the possibility of breakage during distribution and handling, and the plastic ampoules themselves are packaged in a film container filled with inert gas and damaged during distribution or handling after illegal use. It aims to provide a way to prevent the act of disguising as if it were done.

1 is a schematic step diagram of a BFS process for producing a plastic ampoule;

2 is a perspective view of a dual packaging system that is one embodiment of the present invention.

Description of the main symbols in the drawings

10: plastic ampoule 11: parison

12: mold 13: injection tube

14 injection 15 seal mold

20: dual packaging system 30: film container

31: side seal 32: lower seam

33: upper seal 40: nitrogen gas

50: drug drugs

In order to achieve this object, the packaging method of drug drugs of the present invention

Filling a molded plastic container with a medicine and then sealing the top of the container to prepare a plastic ampoule filled with the medicine;

Injecting it into the film container and filling the inside of the film container with an inert gas and then sealing the inlet.

The plastic ampoule is manufactured by a method of forming-filling-sealing in a series of continuous processes, a typical example of which is Blowing-Filling-Sealing (BFS). This process method also has the advantage of significantly lowering the manufacturing cost since molding and filling and sealing of the injection are carried out in one continuous process.

Figure 1 schematically shows the BFS process method, firstly the step (a) of injecting the parison 10 into the mold (12), the blowing blow pin (not shown) and the injection liquid The injection tube 13 having an injection pin (not shown) to be injected therein is lowered into the mold 12, and the mold 12 is opened by the pressurized air injected from the injection tube 13 after the mold 12 is sealed. After the parison 11 is expanded to match the internal shape of the mold 12 and the injection liquid is filled through the injection tube 13 (b), the filling of the injection liquid 14 is completed, the top of the mold 12 The process proceeds to the step (c) of sealing the upper part of the container while the sealing mold 15 is installed, and the step (d) in which the mold is opened and the plastic ampoule 16 is taken out after the sealing is completed. In some cases, a blow pin or an injection pin is not separately installed in the injection tube 13, and the injection of air and injection liquid may be performed through one injection tube by a control box installed at an upper portion thereof. In addition, as shown above, air existing in the space between the parison 11 and the mold 12 is blown through the plurality of vacuum pins perforated in the mold 12 without forming the container body by blow molding. The parison 11 can be inflated to shape the container body by pulling it out of the shell.

Plastic ampoules manufactured by such a process have little possibility of being damaged by impact from the outside due to the characteristics of the plastic. In addition, the opening process of the container is easy, so that the user is not injured by the glass on top of the broken glass ampoule, such as the glass ampoule.

The film container which repackages the plastic ampoule thus manufactured is made of a material of a characteristic capable of sealing a filled gas and having an expanded volume in the filled state. In addition, the drug product is deteriorated by oxygen, so the plastic ampoule itself must have oxygen barrier property or at least the film container must have oxygen barrier property. However, since the inert gas surrounds the exterior of the plastic ampoule again, the inert gas may play a role of pitting the oxygen gas penetrated through the film container.

Examples of a material having an oxygen barrier property which may be used in the film container include an aluminum deposition film, a polyvinylidene chloride (PVDC) coated film, an aluminum foil, a paper barrier film in which paper and an oxygen barrier film are laminated, and the like. Among them, a paper barrier film is particularly preferable. The paper barrier film may be a structure of polyolefin / adhesive layer / paper / adhesive layer / blocking film layer / adhesive layer / polyolefin, or a modified structure thereof. In addition, a barrier film of polyolefin / polyvinyl alcohol / polyolefin or a film using the same may be used. Details of the polyolefin / polyvinyl alcohol / polyolefin barrier film are described in detail in Korean Patent Application Nos. 98-13979 and 98-13980, and it is known that a layer of polyvinyl alcohol has excellent oxygen barrier properties. .

A representative example of the form of the packaging container is a three-sided wrapping paper. Three-side wrapping paper refers to wrapping paper with three sealing parts when folding a flat wrapping paper to make a sealing container. The structure of such three-side wrapping paper is often encountered in everyday life, for example, it can be found in the mail envelope. That is, in a fully unfolded state, the paper is flat, and both ends of the side are sealed to form a cylindrical structure, and when the bottom of the cylindrical structure is sealed, it is a packaging container to hold the contents, and then the contents to be packed are put in Sealing the upper end yields a completely sealed packaging container. In order to execute the manufacturing method of the present invention using such a three-sided wrapping paper, first, both side ends and bottom portions of the three-sided wrapping paper are respectively sealed to form a film container, and then filled with a medicine-filled plastic ampoule, inert gas is injected therein, and the top portion is sealed. It is possible to manufacture double packaging of drug products packaged in plastic ampoules and gas filled film containers. Alternatively, a plastic ampoule is placed on a three-side wrapping paper on a conveyor belt, and both ends and bottoms are sealed together to form a film container with a plastic ampoule, inert gas is injected, and the top is sealed to seal a plastic ampoule and a gas filling film. It is also possible to manufacture double packagings of drug products packaged in containers.

The present invention also relates to a dual packaging system produced by such a method. Specifically, the present invention comprises a plastic ampoule filled with narcotic drugs, and a film container containing the plastic ampoule and filled with an inert gas. The filling degree of the gas is preferably such that the shape of the embedded plastic ampoule is not exposed through the contact surface with the film container. This is to make it possible to distinguish the shape when the film container is broken from the shape when the film container is not broken. The inert gas includes helium gas, nitrogen gas, argon gas, and the like, and nitrogen gas and the like which are particularly inexpensive and easy to handle are particularly preferable. In some cases, the film container may be made of a transparent material, and the pigment may be dispersed in the gas so that the filling of the gas may be easily confirmed in appearance.

An example of the present invention dual packaging system will be described with reference to FIG. The double packaging system of FIG. 2 has a structure in which a film container is formed using three-side wrapping paper.

The plastic ampoule 10 filled with the drug substance 50 is embedded in the film container 30 and filled with nitrogen gas 40 therebetween. The film container 30 is made of a three-side wrapping paper, and is manufactured by sealing the side ends and both ends of the flat wrapping paper. In the film container 30, three seals sealed at the time of forming the container are identified, and the side seal 31, the bottom seal 32, and the upper seal 33 are the same. Nitrogen gas 40 is filled such that the appearance of the plastic ampoule 10 is not completely exposed through the contact surface of the film container 30. Therefore, when the handler intentionally attempts to pull out the drug substance 50 in the plastic ampoule 10 using a syringe or the like, the filled nitrogen gas 40 is discharged, and unlike the shape before the gas is filled, the film container The shape of 30 is flattened, and it can also be confirmed easily.

Therefore, any kind of film container other than the above-described three-sided wrapping paper can be used as long as the film container can realize such an object.

Those skilled in the art to which the present invention pertains will be capable of various applications and modifications within the scope of the present invention based on the above description and the contents of the drawings.

Unlike the conventional glass ampoule packaging, the dual packaging system of the drug product of the present invention has no risk of breakage during transportation and handling, and is inadvertently broken after handling the drug product by the intentional use of the drug product. Even if it is concealed salvage, there is an advantage that can be easily identified, it is very useful to prevent illegal use of drug drugs.

Claims (4)

Filling a molded plastic container with a medicine and then sealing the top of the container to prepare a plastic ampoule filled with the medicine; The method for packaging a drug drug, characterized in that it comprises the step of filling it into the film container and then filling the inside of the film container with an inert gas and sealing the inlet. The method of claim 1, wherein the plastic ampoule is manufactured in a series of continuous processes for forming-filling-sealing. The method of claim 1, wherein the packaging container is manufactured using an oxygen barrier three-side wrapping paper, and the inert gas is nitrogen gas. A double packaging system for narcotic medicines comprising a plastic ampoule filled with narcotic medicines, and a film container containing the plastic ampoule and filled with an inert gas.