KR20010109607A - External applications having antistress effect in the skin - Google Patents

Abstract

The present invention relates to an antistress external preparation composition which protects the skin from various stresses on the skin such as ultraviolet rays, pollution, tobacco smoke, and the like, which contains 0.01 to 5.00 weight of fish extract and 0.01 to 5.00 weight of magnolia extract.

In addition, the external preparation composition of the present invention is 0.001 to 5.00 weight of green tea extract, 0.01 to 5.00 weight of the neo-ceramide (Hydroxypropyl Bispalmitamide MEA; Neo-Ceramide; ceradiamide 16) of the structural formula I and 0.05 ~ 0.5 weight of the combination fragrance 1 It is characterized by containing more than a species.

(Ⅰ)

The composition of the present invention can protect the skin from ultraviolet rays, harmful oxygen, harmful substances drifting in the air, etc. by the synergism of each component, and can prevent the degradation of the skin barrier function due to overcrowding stress caused by urban life, Emotional stability can be promoted to improve skin soothing effect and skin moisturizing effect.

Description

External application having antistress effect in skin

The present invention relates to an antistress external preparation composition which protects the skin from various stresses on the skin such as ultraviolet rays, pollution, tobacco smoke, and the like. Specifically, it contains 0.01 to 5.00 weight of fish extract and 0.01 to 5.00 weight of magnolia extract, or green tea extract 0.001 0.01-5.00 weight and 0.05-0.5 weight of the combination fragrance, and neo-ceramide (Hydroxypropyl Bispalmitamide MEA; Neo-Ceramide; ceradiamide 16) of the following structural formula (I): It can protect the skin from harmful substances drifting in the air, prevent the deterioration of skin barrier function due to over stress due to urban life, and promote emotional stability and increase skin soothing effect and skin moisturizing effect. It relates to an external preparation composition that can be.

The term stress refers to the abnormality that has occurred in the target as a result of an external stimulus, and skin stress refers to internal and external environmental factors that affect the health of the skin.

In other words, harmful elements present in the air, such as ultraviolet rays, harmful oxygen or tobacco smoke, and automobile exhaust gases, which adversely affect the skin condition, act as skin stress. In addition, mental stress caused by overcrowding such as urban life also acts as skin stress.

Therefore, a composition for removing such skin stress has been developed. For example, Korean Patent Laid-Open Publication No. 2000-11151 contains one or two or more components selected from the group consisting of glutathione, thiotaurine, or hypotaurine, tannin, and vitamin C. A composition for preventing environmental stress to remove stress caused by particulates suspended in the air due to artificial causes such as smoke of a factory or a thermal power plant is disclosed. Japanese Patent Laid-Open No. 10-203994 discloses at least one extracted from milk, soybean, and yeast. There is disclosed a cosmetic composition capable of providing an excellent antistress effect by containing a peptide having a molecular weight of 500 to 5,000 produced by applying a protease to one protein.

However, this conventional technique simply protects the skin from external adverse effects such as suspended solids, and in order to remove skin stress caused by internal factors, it is necessary to separately add an antioxidant component or a material having an ultraviolet blocking effect. . That is, the known compositions do not exhibit an antistress effect due to a combination of skin stress caused by internal and external factors.

Thus, the present inventors conducted a intensive study to find an active ingredient that can act in combination with the internal and external factors acting as skin stress, when the combination of the extract and the magnolia extract with antioxidant effect, not only has an anti-inflammatory effect The present invention has been found to be able to alleviate skin irritation caused by sulfur dioxide, tobacco base, and the like.

In addition, green tea extract having a skin peroxidation inhibitory effect and a cell membrane protecting effect, neoceramide or mental stability, which is effective in preventing a decrease in the barrier function caused by over-mild stress, increases skin moisturizing and soothes the skin. When the mixture of Echoseongcho extract and magnolia extract was added to the combination flavor, it was found that the effect of the green tea extract, neoceramide and the combination flavor was further enhanced and the present invention was completed.

Accordingly, an object of the present invention is to provide an antistress external preparation composition that can protect the skin from various stresses on the skin, such as pollutants such as sulfurous acid gas, tobacco smoke, ultraviolet light and the like.

1 is a graph measuring the change in skin temperature in order to confirm the skin soothing effect by the composition of the present invention.

Figure 2 is a graph measuring the change in skin resistance value in order to confirm the skin soothing effect by the composition of the present invention.

In order to achieve the above object, the anti-stress external composition according to the present invention is characterized in that it contains 0.01 ~ 5.00 weight and 0.01 ~ 5.00 weight magnolia extract.

In addition, the composition according to the invention is characterized in that it further contains at least one selected from the group consisting of 0.001 ~ 5.00 weight of green tea extract, 0.01-5.0 weight of neo-ceramide of the formula (I) and 0.05-0.5 weight of the combination fragrance. do.

[Formula 1]

(Ⅰ)

Hereinafter, the present invention will be described in more detail.

In the composition of the present invention, the Echochocho extract is immersed in 50 wt ethanol for one week, dried centrifuged in Houttuynia cordata , centrifuged, and the filtrate is aged while refrigerated, and then filtered using a filter paper.

Conventional fish oil extract has been used for the purpose of purifying the body to discharge toxins and wastes in the body, in the present invention acts as an inhibitor to protect the skin from skin irritation and inflammation caused by harmful substances such as sulfurous acid gas, tobacco smoke and the like.

Eochocho extract, when contained in an amount of 5.0 weight or more based on the total weight of the composition, lowers the viscosity of the formulation due to the influence of salts contained in the external preparation composition, and thus may affect the stability of the formulation in the long term. Since it can not exhibit a significant inhibitory effect on skin irritation and inflammation, it is preferable to contain in an amount of 0.01 to 5.0 weight.

Magnolia extract in the composition of the present invention, the stem and roots of the magnolia (Mognolia kous) dried for 50 days in ethanol, and then centrifuged and filtered, the filtrate is aged while refrigerated, and then filtered using a filter paper Use one.

Conventional magnolia extracts have been used for the purpose of promoting blood circulation, but in the present invention acts as an inhibitor to protect the skin from skin irritation and inflammation caused by harmful substances such as sulfurous acid gas, tobacco smoke and the like.

Magnolia extract in the composition of the present invention is also preferably contained in an amount of 0.01 to 5.0 weight based on the total weight of the composition for the same reason as Eochocho extract.

The external preparation composition of the present invention is a composition for protecting the skin from the pollutants such as sulfurous acid gas, tobacco smoke, etc., containing the above-mentioned Echochocho extract and magnolia extract, when containing a mixture thereof than each case alone The effect is raised.

In addition, when the green tea extract having a skin peroxidation inhibitory effect and a cell membrane protecting effect is further contained in the composition of the present invention, since the effect of the green tea extract is further enhanced, the external preparation composition of the present invention may be used to prevent It is also effective for protection. Green tea extract is preferably contained in an amount of 0.01 to 5.0 weight based on the total weight of the composition.

In addition, when the composition of the present invention further contains neo-ceramide (I), which is effective in preventing the reduction of barrier function due to over-mild stress, the effect of neo-ceramide (I) is further enhanced. Is also effective in protecting skin from overcrowded stress such as urban life. Neo-ceramide (I) is preferably contained in an amount of 0.01 to 5.0 weight based on the total weight of the composition.

In addition, when the composition of the present invention achieves mental stability and further contains a combination fragrance capable of calming the skin and increasing the moisture of the skin, the effect of the combination fragrance is further enhanced. Combination fragrance is composed of a combination of natural essential oils, the overall fragrance series is Citrus Hebal Woody series, 10 weight of natural lemon oil (Lemon oil), 10 weight of natural lavender oil (natural oil), natural chamomile oil It is obtained by mixing and stirring 10 weights of chamomile oil, 30 weights of natural Ylang Ylang oil, 20 weights of natural Cedarwood oil and 20 weights of natural sandalwood oil at room temperature. The combination fragrance used in the present invention can give a better psychological and soothing effect on biomarkers such as alpha waves, skin resistance, skin temperature, etc., compared to lavender oil which is generally known to impart mental stability. In the composition of the present invention, the combination fragrance tends to have a lower odor preference due to strong odor at 0.5 weight or more, and at 0.05 weight or less, it exhibits significant anti-stress action on biomarker effects such as skin temperature, skin resistance and alpha wave. Since it cannot be, it is contained in an amount of 0.05 to 0.5 weight based on the total weight of the composition.

The external preparation composition having an antistress effect of the present invention is not particularly limited in the formulation, for example, a cosmetic composition having a flexible longevity, nourishing longevity, massage cream, nourishing cream, pack, gel or adhesive type formulation It may also be a medicament with a formulation of a lotion, ointment, gel, cream, patch or spray.

The external preparation composition of the present invention may further contain other ingredients in the range that does not inhibit the desired effect of the present invention in addition to the above-described ingredients depending on the formulation.

Hereinafter, the configuration and effect of the present invention will be described in more detail with reference to Examples and Examples of the present invention. However, the present invention is not limited only to these examples.

<Test Example 1> skin irritation relaxing effect

As a test method, Draize's test method was used to measure the skin irritant effect on sulfurous acid, which is the main component of pollution of magnolia extract and Echochocho extract.

Three groups of 2 to 2.5kg male New Zealand white rabbits freely ingested with negative water and solid feed under appropriate conditions (23 ?? 2 ℃, relative humidity 50 ?? 10) were included in groups of 24 hours before hair removal. The back part of each animal was about 1.5cm X 1.5cm around the spine, and the sample material and the control material shown in Table 1 were applied to the administration site at 1.0 g per animal, and the applied site was covered with gauze. It was fixed with non-irritating tape and applied for 24 hours. After 24 hours and 72 hours, the site of application was observed for irritation such as erythema, skin formation and edema formation. Evaluation of skin reaction was judged based on "toxicity test criteria of pharmaceuticals". In addition, the determination of the degree of stimulus for the results was based on commonly used methods of calculating the primary stimulus index (Draize, JH, Appraisal of safety od chemical in foods, drugs and cosmetics.The staff of division of pharmacology, Food and Drug Education and Welfare, Pub. (1959) and Guidelines for the testing of chemical substance (1992) (see OECD, Paris, France). On the other hand, the reason for using H ₂ SO ₄ 10 aqueous solution and Na ₂ SO ₄ 10 aqueous solution as a control material may exist in the form of hydrogen ions and SO _x in the aqueous solution state and thus may exist as a material similar to SO _x , the main component of soot Therefore, it was compared as a control.

[Examples 1-5 and Comparative Examples 1-9]

ingredient Primary Stimulus Index Substance 1 Example 1 + Material 4 0.25 Substance 2 Comparative Example 9 + Substance 4 1.2 Substance 3 Comparative Example 8 + Substance 4 1.5 Substance 4 H ₂ SO ₄ 10 Aqueous + Na ₂ SO ₄ 10 Aqueous 5.5

In the results of Table 1, the primary irritation index (P.I.I) is determined by dividing the average value of the sum of the erythema and edema by the degree of skin reaction in Table 2 below. On the other hand, the primary stimulation index of Table 1 is evaluated based on Table 3 below.

Degree of skin reaction grade 1) No erythema and crust-forming erythema Very mild erythema (only visible to the naked eye) Clear erythema Strong to moderate erythema Strong red erythema and crust formation 2) No edema forming edema weekly mild edema (not visible to the naked eye) Clear edema (distinguishable from clear) Moderate edema (if swollen about 1 mm) Strong edema (swelled more than 1 mm and extended beyond the exposed area) 0123401234

Safety classification Primary irritant index 0 to 0.50.6 to 2.02.1 to 5.05.1 or more No irritation Mild irritation Moderate irritation

From Table 1, it can be seen that the skin irritation-releasing effect is increased in Example 1 using a mixture of 0.01 wt% Echochocho extract and 0.01 wt% magnolia extract.

<Test Example 2> anti-inflammatory effect

After treatment with TPA (Tetradecanoyl Phorbol Acetate) in the rat's ear to induce edema, after 15 minutes, as shown in Table 4, the sample containing the extract of Echo and Magnolia extract 0.01mg / 30μL, and Echocho extract The sample containing 0.02 mg / 30 μl of the sample and the sample containing 0.02 mg / 30 μl of the magnolia extract was applied to the ear, and after 6 hours, the sample was applied once more (0.003 mg / 30 μl). 24 hours after the initial TPA application, a portion of the rat's ear was punched out and weighed, and the degree of MPO (Myeloperoxidase) accumulation inhibition (neutrophil number evaluation) was evaluated. Aspirin and inflammatory effects, which are known to have excellent inflammatory effects, were compared and evaluated. The results are shown in Table 4.

matter density Weight loss ratio () MPO accumulation inhibition rate () Eoseongcho Extract + Magnolia Extract 0.02mg / 30μl 80 77 0.003mg / 30μl 64 59 Aspirin (positive) 0.02mg / 30μl 63 51 0.003mg / 30μl 36 20 Eochocho extract 0.02mg / 30μl 10 8 0.003mg / 30μl 7 5 Magnolia extract 0.02mg / 30μl 15 12 0.003mg / 30μl 10 8

Table 4 shows that the Echochochoea extract and Magnolia extract alone are insufficient in anti-inflammatory effect of Echochocho, but when the extract and Magnolia extract are used together, the local anti-inflammatory effect appears to be aspirin level, a positive control. have.

<Test Example 3> skin peroxidation lipid inhibitory effect

After epilating the back of the guinea pig, 120 μl of the lotion of Example 2, Comparative Example 1 and Comparative Example 7 was applied for 24 hours, and then UVB 50 mJ / cm 2 was irradiated. After 18 hours of ultraviolet irradiation, the skin was biopsied and homogenized with 20-fold sodium phosphate buffer solution (pH 7.4). The obtained tissue solution was centrifuged at 15,000 rpm for 5 minutes, and the supernatant was taken and used for the experiment. To quantitate lipid peroxide, react the tissue supernatant with tiobarbituric acid (TBA) of 1, and then measure the fluorescence at excitation 515 nm and absorption 553 nm using a fluorescence spectrophotometer, and then use 1,1,3,3 as standard. -Tetraethoxy propane (TEP) was used to prepare a standard curve to compare and quantify lipid peroxide, and the results are shown in Table 5 (S. Gonalez, MA Pathak: Inhibition of ultraviolet-induced formation of reactive oxygen species, lipid peroxidation, erythema and skin photosensitization by polypodium leucotomos, Photodermatol.Photoimmunol.Photomed. 12, 45-56 (1996) and Y. Shido, E. Witt, D. Han: Recovery of antioxidants and reduction in lipid hydroperoxides in murine epidermis and dermis after acute ultraviolet radiation exposure, Photodermatol.Photoimmunol.Photomed. 10, 183-191 (1994).

ingredient Lipid peroxide (nmol / mg protein) Lipid peroxide production inhibition rate () Comparative Example 1 838.1 ?? 144 0 Comparative Example 7 355.1 ?? 48 57 Example 2 286.8 ?? 57 66

From Table 5, it can be seen that the green tea extract is effective in inhibiting the production of lipid peroxidation by free radicals generated during ultraviolet irradiation, and this effect is further enhanced by the mixed use with the Echo extract and Magnolia extract.

Test Example 4 Inhibition Effect of Photohemolysis

The red blood cells used in the experiment were obtained from healthy rabbits 6 months of age purchased from Samyuk Livestock Farm (Hwaseong-gun, Gyeonggi-do). Immediately after collection, the blood was placed in a test tube containing sodium citrate, and centrifuged at 3,000 rpm for 5 minutes to separate red blood cells and plasma, and the separated red blood cells were 0.9 narium phosphate buffer solution (pH 7.4, Na ₂ HPO ₄ 12H ₂ O 1.6 mM). ) And centrifuged. After centrifugation, the white leukocyte layer immediately above the precipitated red blood cells was removed. After repeated three times, washed and separated erythrocytes were used while stored in a refrigerator at 4 ℃, all experiments were performed within 12 hours after blood collection.

3.5 ml of a 1.5 × 10 ⁷ RBC / ml suspension was placed in a Pyrex test tube (No. 9820), and the test substance was dissolved in ethanol and 50 μl each was added thereto. After pre-incubation for 30 minutes in the dark, 0.5 ml of rose-bengal (12 μM) was added as a photosensitizer, the inlet was sealed with parafilm, and irradiated with light for 15 minutes. The light irradiation required for light hemolysis was carried out by placing a 20W fluorescent lamp (FL-20D Kumho Electric Co., Ltd.) in a 50cm x 20cm x 25cm black box filled with black inside and paralleling the Pyrex test tube containing a suspension of red blood cells 5cm away from the fluorescent tube. After arranging the tube, the tube was examined. After light irradiation, the rate of destruction of erythrocytes by post-incubation was determined from the decrease in light transmittance by scattering at 700 nm at 15 minute intervals. At this wavelength, the decrease in light transmittance by scattering of the suspension of red blood cells is proportional to the concentration of red blood cells.

Each sample was averaged four times at a time and repeated three times. Hemolysis was determined by the ratio of the OD of the erythrocyte suspension in which hemolysis proceeded to the OD indicated by the erythrocyte suspension before irradiation. Phosphorus τ ₅₀ was obtained and compared.

sample τ ₅₀ (half-time hemolysis; min) Comparative Example 1 32 Comparative Example 7 60 Example 2 260

From Table 6, it can be seen that the green tea extract can inhibit photohemolysis, and thus has a photoprotective effect on the erythrocyte cell membrane, and the effect is further increased when used together with Echo extract and Magnolia extract.

Experimental Example 5 Protective Effect on Barrier Damage by Community and Mill Stress through Animal Experiment

The protective effect of barrier function on the change of skin function by overload stress in hairless mice was evaluated. First, 10 animals were raised in 27cm x 22cm x 13cm in rearing hairless mice in order to overload the stress. 5 parts of the lotion of Comparative Example 1, Comparative Example 5, Example 3 and Example 5 were measured using EP1 which is an evaporimeter (servomed) as a reference value, and divided into a sample application group and a stress group. The extent to which barrier function was protected was evaluated by measuring the amount of epidermal moisture loss applied to the area and decreasing the amount. It measured after 2 days, 4 days, and 7 days, respectively, and the result is shown in Table 7.

Recovery rate 2 days elapsed (based on initial TEWL) 4 days elapsed (based on initial TEWL) 7 days elapsed (based on initial TEWL) Comparative Example 1 68.5 49.3 13.6 Comparative Example 5 55.2 43.2 12.1 Example 3 40.2 33.8 8.5 Example 5 30.1 21.2 4.1

From Table 7, it can be seen that the protective effect of the barrier function is shown by neo-ceramide, and that the effect is increased when it contains more Echochocho extract and magnolia extract than when neo-ceramide is included alone. Can be.

<Test Example 6: Skin soothing effect human test>

To compare the skin soothing effect of the lotion prepared in Examples and Comparative Examples, 6 adult males and females in their 20s to 30s who have no sense of smell, no physical and psychological stress, and have not experienced drinking or smoking until 3 days ago Was tested. The experimental method is as follows.

The subjects were given the lotion of Comparative Examples 1 to 4, Comparative Example 6 and Examples 1 to 5 for 1 minute. In order to eliminate the effects of the order, 7 types were performed by random order. As a control of the comparative example, distilled water was measured before, during and after the experiment, and the jasmine having good arousal effect and the lavender-containing group showing the relaxation effect were compared with the neurodata (Neurodata). ) Was analyzed by Acqknowledge ver 3.2.4 using a 1200 (Grass, USA) device.

Because, when incense is generally stimulated sensory receptors distributed in the mucous membrane of the nose, these signals are transmitted to the cerebrum, causing two kinds of sensations of calming or arousal. It affects the autonomic nervous system and the central nervous system. Therefore, it measures the skin resistance (GSR-Galvanic Skin Resistance) or skin temperature of the autonomic nervous system or the brain wave which is a biomarker of the central nervous system. will be.

Experimental results are shown in FIGS. 1 and 2.

From FIG. 1, the skin temperature of the Comparative Example 2 containing the jasmine fragrance having a skin arousal effect tended to increase, and in Comparative Example 4 in which jasmine and the lavender fragrance having a relaxing effect were mixed, slightly compared to Comparative Example 2. The skin temperature was increased, and it can be seen that the skin temperature was slightly decreased in the case of Comparative Example 6 containing the combination fragrance. In addition, in the case of Example 4 using the Echochocho extract and Magnolia extract together with the combination fragrance, since the decrease in the skin temperature is greater than that of Example 1 containing only the Echochocho extract and Magnolia extract and Comparative Example 6 containing only the combined aroma, excellent skin It can be seen that it has a calming effect.

In addition, also in the evaluation of skin resistance of FIG.

From the above results, it can be seen that the skin soothing effect is superior to the case of containing the fragrance alone and the combination of the fragrance rather than the simple mixed fragrance. It can be seen that the calming effect is further enhanced.

<Test Example 7: increase skin moisturizing power and measure skin calming effect through human body test>

The skin moisturizing improvement effect was compared with respect to the lotion of Comparative Examples 1 to 4, Comparative Example 6, Example 4 and Example 5, and the sensitivity measurement on the skin soothing effect was performed through subjective evaluation.

Skin moisturizing effect was divided into four groups of 200 people in their 20s and 30s. The test method is as follows. That is, give each group a lotion and apply it to the face and forearm area twice a day for 1 month and at the constant temperature and humidity conditions (24 ℃, 40 humidity) before the start of the corneometer (corneometer; CM820 courage + Khazaka elctronic GmbH, Germany) to measure the skin conductivity and use it as a basic value, and measure the change in skin moisture content after 1 week, 2 weeks, 4 weeks, and 2 weeks after the application was stopped (6 weeks). Was evaluated and the results are shown in Table 8.

In addition, subjective efficacy evaluation was conducted through a questionnaire for the test subjects, and the results are shown in Table 9.

Skin moisture growth rate () 1 week 2 weeks 4 weeks 6 weeks Comparative Example 1 8 9 13 4 Comparative Example 2 10 11 25 18 Comparative Example 3 12 14 24 14 Comparative Example 4 12 12 20 14 Comparative Example 6 15 14 23 20 Example 4 25 24 32 30 Example 5 40 48 53 47

Skin Drying Improvement Assessment (Survey) Very good Good usually Inadequate Comparative Example 1 8 22 54 16 Comparative Example 2 15 45 30 10 Comparative Example 3 25 30 41 4 Comparative Example 4 24 40 20 16 Comparative Example 6 31 28 20 21 Example 4 52 32 10 6 Example 5 60 34 6 -

Hereinafter, on the basis of the results of the above test example, by containing the green tea extract, eochocho extract, magnolia extract, neo-ceramide and combination fragrance can provide an anti-stress effect that can protect the skin from various stresses on the skin Formulations of external preparations of various formulations are presented. However, the composition of the present invention is not limited to the following examples.

Example 6 Flexible Cosmetics

Ingredient Ingredient ratio (weight) Methyl paraben natural stabilized polyoxyethylene cured castor oil polysiloxane tocopherol ethanol neo-ceramide propylene glycol carboxyvinyl polymer green tea extract fish vinegar extract magnolia extract 0.20.20.40.112.00.56.00.120.50.50.5TO 100

(Example 7): Essence

Ingredient Ingredient ratio (weight) Methyl paraben natural stabilized octyl dodec-16 choles-24 / cetes-24 polysiloxane acetate tocopherol ethanol glycerin neo-ceramide carbonate gum propylene glycol carboxyvinyl polymer green tea extract fish herbal extract magnolia extract purified water Accurate 0.20.50.20.40.16.015.00.50.074.00.120.50.50.5TO 100

Example 8 Nutrition Cream

Ingredient Ingredient ratio (weight) Liquid paraffin cetostearyl alcohol beeswax polysiloxane lipophilic monostearic acid stearate neo-ceramide stearic acid sorbitan sesquioleate monostearic acid polyoxyethylene sorbitan (20 EO) methyl paraben propyl paraben natural stable aromatic ethylene polyamine tetra acetate sodium glycerine carboxy vinyl polymer Propylene Glycol Green Tea Extract Fish Herb Extract Magnolia Extract 15.02.03.00.52.00.52.00.71.30.20.10.20.025.00.102.00.50.50.5TO 100

Example 9 Gel

Ingredient Ingredient ratio (weight) Natural antiseptic glycerin jojoba wax diepan tenol ethanol neo-ceramide carboxyvinyl polymer propylene glycol green tea extract fish seaweed extract magnolia extract purified water Appropriate 0.25.03.01.07.00.50.63.00.50.50.5TO 100

Example 10 Pack

Ingredient Ingredient ratio (weight) Methyl paraben natural lavender flavored polyoxyethylene hardened castor oil polysiloxane cellulose gum ethanol neo-ceramide glycerin propylene glycol polyvinyl alcohol green tea extract fish seaweed extract purified water Suitable 0.20.60.20.26.00.55.03.015.00.50.50.5TO 100

(Example 11); Cream ointment

Ingredient Ingredient ratio (weight) Liquid paraffin cetostearyl alcohol lipophilic monostearic acid stearate neo-ceramide stearic acid sorbitan sesquilate monostearic acid polyoxyethylene sorbitan (20 EO) methyl paraben propyl parabene natural stable ethylene polyamine tetra acetate sodium glycerine carboxy vinyl polymer propylene glycol Green Tea Extract Fish Herb Extract Magnolia Extract 15.02.02.00.51.50.71.30.20.10.20.023.00.102.00.50.50.5TO 100

As described above, the external preparation composition according to the present invention can protect the skin from skin irritation and inflammation caused by pollutants, tobacco smoke, etc. containing Echochocho extract and magnolia extract, green tea extract, neoceramide (I) and combination It contains more fragrance to protect the skin from UV rays, prevents the deterioration of skin barrier function caused by excessive stress caused by urban life, etc., and promotes emotional stability to increase skin soothing and moisturizing effect. Can be.

Claims (2)

An antistress topical composition comprising 0.01 to 5.00 weight of fish extract and 0.01 to 5.00 weight of magnolia extract. According to claim 1, characterized in that it further contains at least one selected from the group consisting of 0.01-5.0 weight of green tea extract, 0.01-5.0 weight of neo-ceramide of the following structural formula (I), and 0.05-0.5 weight of the combination fragrance. Stress external preparation composition. [Formula 1] (Ⅰ)